Blood Products Advisory Committee Curriculum Vitae Elena Perez

Blood Products Advisory Committee Curriculum Vitae Elena Perez, CBER, Biologics

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Alan Koterba, M.D., Ph.D. Elena E. Perez, M.D., Ph.D.

Curriculum Vitae

I.

PERSONAL

Elena E. Perez, MD/PhD, FAAAI

954-589-5921(home)

561-626-2006(office)

106 Rockingham Road

Jupiter, FL 33458

United States Citizen

Adult/Pediatric Allergy & Immunology Updated 2/8/2019

II.

HIGHER EDUCATION

Institutional:

· University of Florida; B.S. Microbiology; 1991

· University of Florida; M.D. Medicine; 1998

· University of Florida; Ph.D. Interdisciplinary Biomedical Sciences; 1998

· Children's Hospital of Philadelphia; Intern and Resident in Pediatrics; 1998-2001

· Children's Hospital of Philadelphia; Fellowship in Allergy and Immunology; 2001-2004

· University of Pennsylvania; Post-doctoral research fellow; 2002-2004

Board Certifications:

· Diplomat, American Board of Pediatrics, Certificate # 073727,

Original Certification: October 16, 2001; Re-certification: September 30, 2008

· Diplomat, American Board of Allergy & Immunology, Certificate #5101

Original Certification: October 14, 2005

Licensure:

· State of Florida Board of Medicine,

ME103841 02/27/2009-01/31/2019

· Commonwealth of Pennsylvania Department of State

MD071411L 06/16/2000-12/31/2008

III. EXPERIENCE

· Children's Hospital of Philadelphia; Instructor, Pediatrics; 1998-2001

· Children's Hospital of Philadelphia/University of Pennsylvania; Instructor, Allergy and Immunology; 2004-2005

· Children's Hospital of Philadelphia "CHOP" Connection; Attending Physician, Pediatric Hospitalist, Chester County Hospital;

2001-2008

· Children's Hospital of Philadelphia; Attending Physician; 2004-2009

· University of Pennsylvania School of Medicine; Assistant Professor of Pediatrics; 2005-2009

· University of South Florida; Assistant Professor of Pediatrics, Division of Allergy, Immunology and Rheumatology;

2009- 2011

,

· All Children's Hospital; Attending Physician; 2009-2012

· Children's Research Institute, Research Laboratory Director, Division of Allergy, Immunology, Rheumatology, University of

South Florida, St. Petersburg 2009-2012. Supervised CLIA certified flow cytometry panels for lymphocyte subsets (T, B, NK)

including sign off/interpretation, trouble shooting, and quality control. Reviewed QC and proficiency testing for 2009-2012.

Also supervised research projects including molecular work, cell culture, blood cell separation, cryopreservation and cell

sorting using BD instruments.

· Associate Professor of Pediatrics, Division of Allergy, Immunology and Rheumatology, University of South Florida; 2011-

2012

· Associate Professor of Pediatrics; University of Miami 2013-2015 Clinical Educator Track, Department of Pediatrics

· Allergy Associates of the Palm Beaches, Associate 2016

840 U.S. Highway One Suite 235, North Palm Beach, FL 33408 Phone: 561-626-2006 1411 North Flagler Drive Suite 4100, West Palm Beach, FL 33401 Phone: 561-659-5916

Fax: 561-626-8622

Email: office@pballergy.com

HONORS AND AWARDS

1992-1997 1992-1995 1994 1995 2001 2002-2003 2006-2007 2010
2012
2012

Minority Pre-doctoral Fellowship Award, National Institute of General Medical Sciences President, Medical Class of 1995, University of Florida College of Medicine Award for Outstanding Academic Achievement and Leadership, University of Florida College of Medicine Class Contribution Award from Medical Class of 1995, University of Florida College of Medicine Selection to the Clinical Immunology Society-Summer School in Clinical Immunology Glaxo Smith Kline Allergy/Immunology Fellowship Award, Children's Hospital of Philadelphia McCabe Award for Research, University of Pennsylvania Recognition for Service as Chair of the Primary Immunodeficiency Disease Committee, American Academy of Allergy, Asthma and Immunology Recognition award for leadership, dedication and service as the Primary Immunodeficiency Disease Committee Chair 2009-2012 Fellow of the American Academy of Allergy Asthma and Immunology

SOCIETY MEMBERSHIPS

1998-present 2001-2004 2001-present 2001-present 2012 2007 2010

American Academy of Pediatrics (AAP) American College of Allergy Asthma and Immunology (ACAAI) Clinical Immunology Society (CIS) American Academy of Allergy Asthma and Immunology (AAAAI) Fellow, American Academy of Allergy Asthma and Immunology (AAAAI) Society for Pediatric Research (SPR) Florida Allergy Asthma and Immunology Society (FAAIS)

EDITORIAL BOARDS

Reviewer, Clinical Immunology Reviewer, American Society of Microbiology Journals Reviewer, Frontiers in Immunology Abstract Reviewer, American Academy of Allergy Asthma and Immunology Abstract Reviewer, Clinical Immunology Society

TEACHING

1998-2001 2001-2004 2004 2004 2004-2008 2004-2008
2005 2007-2008

Instructor Pediatrics, University of Pennsylvania Daily Fellow rounds with Pediatric Residents Course Instructor, Children's Hospital of Philadelphia Allergy, Immunology, and Infectious Diseases Review Course for the Primary Care Physician (CME Program) Course Instructor, Children's Hospital of Philadelphia, Primary Immunodeficiency: A Window of Opportunity for the Primary Care Provider (CME Program) Attending Clinical Rounds with Inpatient Immunology Team Children's Hospital of Philadelphia, daily for three months/year Clinical Outpatient Resident and Fellow Teaching, weekly during immunology outpatient clinic, Children's Hospital of Philadelphia.[Fellows trained: Meredith Heltzer, MD, David Naimi, MD, Gary Pien, MD, Audrey Park, MD, Laura Gober, MD, Soma Jyonouchi, MD, Lisa Forbes, MD, Rushani Saltzman, MD] Course Instructor, Children's Hospital of Philadelphia Ninth Annual Practical Review for the Clinician, Pediatric Allergy, Immunology and Infectious Diseases. Immunodeficiency Case Presentations. (CME) Course lecturer, CAMB510-001: University of Pennsylvania Graduate Group, Cell and Molecular Biology
Immunology for CAMB Students, "Gene Therapy for Primary Immunodeficiency." [The purpose of this course is to
give a thorough grounding in Immunology to Cell and Molecular Biology graduate students with an emphasis on the role of the immune system in combating infectious and neoplastic diseases and its role in immunopathological states such as autoimmunity and allergy. This is a required course for CAMB students in the Microbiology, Virology and Parasitology program and the Vaccine and Gene Therapy program of the University of Pennsylvania Graduate School.]

2008-present 2009-present

Member, Graduate Student Doctoral Dissertation Committee for Jessica Taffe, University of Pennsylvania. [Provided mentoring and guidance for preliminary exam, and provided feedback at all committee meetings] Weekly Attending Clinical Rounds with Inpatient Immunology Team, All Children's Hospital [Fellows trained: Woei Eng, MD, Jason Caldwell, DO, Panida Sriaroon, MD, Maliena Longley, MD, Loren Isakson, MD, Hava Ladinsky, MD, Jean Brown, MD]

2009-present 2009-present 2009 2009 2010 2010 2010 2010 2010 2010 2010-2012 2012-2015
2013-2015 2013-2015
2013-2015 2014-2015

Weekly Attending Clinical Outpatient Resident Elective and Fellow teaching during Allergy Immunology Outpatient Clinic, USF/All Children's Hospital. [Fellows trained: Woei Eng, MD, Jason Caldwell, DO, Panida Sriaroon, MD, Maliena Longley, MD, Loren Isakson, MD; Visiting residents: Jean Brown, MD] Research laboratory mentor for medical, premedical, predental, and undergraduate students: [Students trained: David Kellogg (dental-Columbia), Olivia Potter (medical-NOVA), Erin Kellner (medical-USF), Stephanie Hudey (premedical), Shikeria Green (premedical-USF)] Course instructor, All Children's Hospital Practical Pediatrics Pasco County, FL "Approach to Food Allergy in Children", (CME Program) Course instructor, St. Jude Hospital "Lunch and Learn HIV session" Teleconference for USF and St. Jude Hospital, "ZFN technology for treatment of HIV" St. Petersburg, teleconferenced to Tennessee. Course instructor, University of South Florida, Allergy and Immunology Fellowship Program Lecture Series, "T Cell and Combined Immunodeficiencies." February 10, 2010. Course instructor, University of South Florida, Allergy and Immunology Fellowship Program Research Lecture Series, "Creating HIV resistant T cells using Zinc Finger Nuclease Technology" August 27, 2009. Preceptor, University of South Florida Allergy and Immunology Fellowship Program Board Review Lecture Series, "Effector Mechanisms of Cell Mediated Immunity" January 8, 2010 Preceptor, University of South Florida Allergy and Immunology Fellowship Program Board Review Lecture Series, "Congenital and Acquired Immunodeficiencies" April 23, 2010 Preceptor, Pediatric Board Review University of South Florida Pediatric Residents, Tampa, Florida, April 2010 Course instructor, Immune Deficiency Foundation, Miami Children's Hospital. "Laboratory Testing and Diagnosis of Primary Immunodeficiency Disorders," Miami, Florida (CME Course) Course instructor, BMS 6200 PMIID, Molecular basis of primary immunodeficiency diseases and clinical presentation. Starting Fall 2010. Course Director, Resident Elective rotation in Pediatric Allergy/Immunology, University of Miami. [residents trained include from Internal Medicine, Med Peds, and Pediatrics Residency program at JMH: Lina Maichel MD, Luz Barahona MD, Hayley Alfanador MD, Carolyn Kienstra MD, Rebecca Kimsey MD, Giovanna Beauchamp Richards MD, Tessa Bandham MD, Magdalenis Gongora MD, Carolina Mendoza MD, Saisha Muniz-Alers MD, Marytery Fajardo MD, Mihai Dumitrescu MD, Babak Moghimi MD, Caroline Caperton MD, Loann, Heuring MD, Rafle Fernandez MD, Amrita Baghat MD, Nicole Cooper MD, Tynsia Harvey MD, Katarzyna Bigaj MD,] Course Director, Medical Student elective (MDR Course #973) [Students trained: Molly McGetrick, Jacqueline Squire, Anam Mendha, Jessica Hochberg, Ann Kurian, Melissa Stone, Abbye Degan] Course Director, International Observership in Pediatric Allergy/Immunology for The William J. Harrington Medical Training Programs for Latin America, the Carribean, and Global Observerships. Countries represented include: Romania, Ecuador, Mexico, Columbia, Brazil, Chile, India, and others. [Students trained: Juan Lopez Zertuche, Ha Na Kim, Lorena Flor, Isabel Velez, Cynthia Arana, Olga Castiblanco, Mahathi Indaram, Andrea Caceres, Mariana de Melo, Nataly Sanchez, Nicole Diaz, Angela Bastides] Pediatric Review Course for JMH Residents, yearly review sessions. Pediatric Academic Half Day. Lectured to pediatric residents on topics in allergy/immunology for board preparation.

RESEARCH AND SCHOLARLY ACTIVITIES

Research Awards

1995
2003 2003-2004

Co-Investigator, National Institute of General Medical Sciences (NIGMS) Minority Predoctoral Fellowship Program, 5-31CM014899 Recipient, Glaxo SmithKline Allergy Fellowship Award Co-Investigator, Ruth L. Kirschstein National Research Service Award, 5-T32-HL07776-09

2004-2010 2005-2006 2006-2007 2007-2009 2008
2017

Principal Investigator, K08 AI062468-6 "Generation of HIV Resistant Primary CD4 T cells," [$116,262/year] This study aims to develop gene translational therapies using genetically modified CD4T cells for the treatment of HIV Co-Investigator, K12 Children's Health Research Career Development Award, National Institute of Child Health and Human Development, (NICHD) Principal Investigator, McCabe Award, University of Pennsylvania, AAV2 as a vector for gene therapy in stem cells Principal Investigator, Development of CCR5 ZFNs in HIV Therapy, Sponsored Research Agreement through Children's Hospital of Philadelphia, Sangamo Biosciences Principal Investigator, "A phase III Open-Label, Prospective, Multi-Center Study of the Efficacy, Tolerability, Safety, and Pharmacokinetics of Immune Globulin, Subcutaneous (Human) IgPro 20 in Subjects with Primary Immunodeficiency (PID)" Protocol # ZLB04_009CR, in conjunction with ZLB Behring Clinical Investigator, "Real-World AR101 Market-Supporting Experience Study in Peanut-Allergic Children Ages 4 to 17 Years (RAMSES)" Aimmune Therapeutics, Inc. protocol ARC007

2004-2010 2009-2012
2009-2011
2011-2012 2015

Funding Principal Investigator, K08 AI062468-6 "Generation of HIV Resistant Primary CD4 T cells," [$116,262/year] This study aims to develop gene translational therapies using genetically modified CD4T cells for the treatment of HIV Principal Investigator, R03AI083904-9 "Uncovering Costimulatory T-cell Help Defects in Common Variable Immunodeficiency Disease (CVID)" [$50,000/year] This study examined T-cell help in subjects with CVID and normal healthy donors, in search of deficits in immune co-stimulation required for antibody production. Principal Investigator, All Children's Hospital Foundation, Institutional Grant "Investigation of T-cell help deficits in Primary Immunodeficiency diseases using a novel artificial antigen presenting cell system to deliver costimulatory signals to T-cells" [$50,000/year] Principal Investigator, CSL Behring Investigator Initiated Research Grant, Examining the cost differential of early versus late diagnosis of Severe Combined Immunodeficiency Disease. Principal Investigator, Horizon Pharma Investigator Initiated Research Grant, The role of Perforin 2 in Chronic Granulomatous Disease

PEER REVIEWED PUBLICATIONS

1. Barrie KA, Perez E, Lamers SL, Farmerie WG, Dunn BM, Sleasman JW, Goodenow MM. Natural variation in HIV-1 protease, Gag p7 and p6, and protease cleavage sites within gag/pol polyproteins: amino acid substitutions in the absence of protease inhibitors in mothers and children infected by human immunodeficiency virus type 1. Virology. 219(2): 407-16, May 15 1996.
2. Perez E, Rose SL, Peyser B, Lamers SL, Burkhardt B, Dunn BM, Hutson AD, Sleasman JW, Goodenow MM. Human immunodeficiency virus type 1 protease genotype predicts immune and viral responses to combination therapy with protease inhibitors (PIs) in PI-naive patients. Journal of Infectious Diseases. 183(4): 579-88, February 15 2001.
3. Goodenow MM, Bloom G, Rose SL, Pomeroy SM, O'Brien PO, Perez E, Sleasman JW, Dunn BM. Naturally occurring amino acid polymorphisms in human immunodeficiency virus type 1 (HIV-1) Gag p7 (NC) and the C-cleavage site impact Gag-Pol processing by HIV-1 protease. Virology. 292(1): 137-49, January 5 2002.
4. Perez E, and Sullivan, KE, Chromosome 22q11.2 deletion syndrome (DiGeroge syndrome/velocardiofacial syndrome). Current Opinion in Pediatrics. 14(6): 678-83. December 2002.
5. Perez E, Bokszczanin A, McDonald-McGinn D, Zackai EH, Sullivan KE. Safety of live viral vaccines in patients with chromosome 22q11.2 deletion syndrome (DiGeorge syndrome/velocardiofacial syndrome). Pediatrics. 112(4): e325, October 2003.
6. Perez E, Riley JL, Carroll RG, von Laer D, June CH. Suppression of HIV-1 infection in primary CD4 T cells transduced with a self-inactivating lentiviral vector encoding a membrane expressed gp41-derived fusion inhibitor. Clinical Immunology. 115(1): 26-32, April 2005.
7. Blank C, Smith LA, Hammer DA, Fehrenbach M, Delisser HM, Perez E, Sullivan KE. Recurrent infections and immunological dysfunction in congenital disorder of glycosylation la (CDG Ia) J Inherit Metab Dis. 29 (4): 592-592 Aug 2006.
8. Onigbanjo M, Orange J, Perez E, and Sullivan K. Hypogammaglobulinemia in a pediatric tertiary care setting. Clinical Immunology. 125(1):52-9. October 2007. (Epub July 12, 2007).
9. Heltzer ML, Paessler M, Raffini L, Bunin N, and Perez E. Successful haploidentical bone marrow transplant in reticular dysgenesis: three year follow-up. Journal of Allergy and Clinical Immunology. 120(4):950-2. October 2007. (Epub Sep 12, 2007)

10. Suhoski M*, Perez E*, Heltzer M, Laney A, Saitta S, Nachman S, Spinner N, June C, Orange J. Monosomy 1p36 associated with OX40 haploinsufficiency and immune deficiency. Clinical Immunology. 128(2):181-189. August 2008. (*authors contributed equally to this work)
11. Perez E, Jouvenot Y, Wang J, Miller, JC, Kim K, Liu O, Wang N, Lee G, Bartesevic V, Lee Y, Guschin D, Rupniewski I, Waite A, Carpenito C, Carroll R, Orange J, Urnov F, Rebar E, Ando D, Gregory P, Riley J, Holmes M, and Carl H. June. Establishment of HIV-1 resistance in CD4 (+) T cells by genome editing using zinc-finger nucleases. Nature Biotechnology. (26)7: 808-816. June 2008.
12. Ho SK, Perez E, Rose SL, Lowe AC, Smith LE, Lawrence RM, Dunn BM, Ma C, Sleasman JW, Goodenow MM. Viral and immune responses to combination antiretroviral therapy are related to genetic determinants in human immunodeficiency virus type 1 (HIV-1) gag-pol and env V3. AIDS. 23(13):1631-1640. August 2009.
13. Orange JS, Glessner JT, Resnick E, Sullivan KE, Lucas M, Ferry B, Kim CE, Hou C, Wang F, Chiavacci R, Kugathasan S, Sleasman JW, Baldassano R, Perez E, Chapel H, Cunningham-Rundles C, Hakonarson H. Genome-wide association identifies diverse causes of common variable immunodeficiency. J Allergy Clin Immunol. 2011 Jun; 127(6):1360-1367.e6. Epub 2011 Apr 17.
14. DiNardo L, Brown V, Perez E, Bunin N, Sullivan, KE. A Single Center Study of Hematopoietic Stem Cell Transplantation for Primary Immune Deficiencies. Pediatric Transplantation, Nov 2011.
15. Pedroza L, Kumar V, Sanborn K, Niinikoski H, Nadeau K, de Moraes Vasconcelos D, Perez E, Jyonuchi S, Jyonuchi H, Ruuskanen O, Condino-Neto A, Orange J. AIRE participates in the dectin-1 induced inflammatory response and complexes with CARD9, syk, and dectin-1. accepted, Journal of Allergy and Clinical Immunology. August 2011.
16. Conley, ME, Dobbs, AK, Quintana, AM, Bosompem, A, Wang, YD, Coustan-Smith, E, Smith, A., Perez, E, Murray, P. Agammaglobulinemia and absent B lineage cells in a patient lacking the p85alpha subunit of PI3K. Journal of Experimental Medicine. February 2012.
17. Orange JS, Ballow M, Stiehm ER, Ballas ZK, Chinen J, De La Morena M, Kumararatne D, Harville TO, Hesterberg, P, Koleilat M, McGhee, S, Perez, EE, Raasch J, Scherzer R, Schroeder H, Seroogy C, Huissoon A, Sorensen RU, Katial R. Use and interpretation of diagnostic vaccination in primary immunodeficiency: A Working Group Report of the Basic and Clinical Immunology Interest Section of the American Academy of Allergy Asthma and Immunology. J Allergy Clin Immunol. 2012 Sep;130(3 Suppl):S1-24.
18. Maier DA, Brennan AL, Jiang S, Binder-Scholl GK, Lee G, Plesa G, Zheng Z, Cotte J, Carpenito C, Wood T, Spratt SK, Ando D, Gregory P, Holmes MC, Perez EE, Riley JL, Carroll RG, June CH, Levine BL. Efficient clinical scale gene modification via zinc finger nuclease-targeted disruption of the HIV co-receptor CCR5. Hum Gene Ther. 2013 Mar;24(3):245-58. doi: 10.1089/hum.2012.172. Epub 2013 Mar 6.
19. Shapiro RS, Boyle M, Perez EE. Local and national advocacy support. J Clin Immunol. 2012 Sep;32 Suppl 2:S423-6. Epub 2012 Jul 19.
20. Elizalde A, Perez EE, Sriaroon P, Nguyen D, Lockey RF, Dorsey MJ. Intensive educational course in allergy and immunology. Allergy. 2012 Sep;67(9):1085-6. doi: 10.1111/j.1398-9995.2012.02869.x.
21. Sriaroon P, Elizalde A, Perez EE, Leiding JW, Aldrovandi GM, Sleasman JW. Psychrobacter immobilis Septicemia in a Boy with X-linked Chronic Granulomatous Disease and Fulminant Hepatic Failure. J Clin Immunol. 2014 Jan; 34(1):39-41, epub 2013 Nov 12.
22. Glessner J, Keller M, Resnick E, Perez E, Chapel H, Lucas, M, Chiavacci R, Kim C, Sullivan K, Cunningham-Rundles C, Orange J , Hakonarson H, Burden of Copy Number Variation in Common Variable Immunodeficiency. Clin Exp Immunol. 2013 Dec 13. doi: 10.1111/cei.12255.
23. Kubiak C, Jyonouchi S, Kuo C, Garcia-Lloret M, Dorsey MJ, Sleasman J, Zbrozek AS, Perez EE. Fiscal implications of newborn screening in the diagnosis of severe combined immunodeficiency. J Allergy Clin Immunol Pract. 2014 Nov-Dec;2(6):697-702. doi: 10.1016/j.jaip.2014.05.013. Epub 2014 Aug 28.
24. Tillipman Ladinsky H, Perez E, Dorsey MJ. Chronic granulomatous disease associated colitis leading to profound zinc deficiency. JACI: In Practice. Volume 2, Issue 2, March-April 2014.
25. Lipshultz SE, Chandar JJ, Rusconi PG, Fornoni A, Abitbol CL, Burke GW 3rd, Zilleruelo GE, Pham SM, Perez EE, Karnik R, Hunter JA, Dauphin DD, Wilkinson JD. Issues in solid-organ transplantation in children: translational research from bench to bedside. Clinics (Sao Paulo). 2014;69 Suppl 1:55-72.
26. Routes J, Abinun M, Al-Herz W, Bustamante J, Condino-Neto A, De La Morena MT, Etzioni A, Gambineri E, Haddad E, Kobrynsky L, Le Deist F, Nonoyama S, Oliveira JB, Perez E, Picard C, Rezaei N, Sleasman J, Sullivan K, Torgerson T. ICON: The Early Diagnosis of Congenital Immunodeficiencies. J Clin Immunol. Epub March 2014. 2014 May; 34(4):398-424.
27. Keller M, Glessner J, Resnick E, Perez E, Chapel H, Lucas M, Sullivan K, Cunningham-Rundles C, Orange J, Hakonarson H. Burden of Copy Number Variation in Common Variable Immunodeficiency. Clinical and Experimental Immunology. June 9 2014 DOI: 10.1111/cei.12255
28. Maggadottir SM, Li J, Glessner JT, Li YR, Wei Z, Chang X, Mentch FD, Thomas KA, Kim CE, Zhao Y, Hou C, Wang F, Jørgensen SF, Perez EE, Sullivan KE, Orange JS, Karlsen TH, Chapel H, Cunningham-Rundles C, Hakonarson H. Rare variants at 16p11.2

are associated with common variable immunodeficiency.J Allergy Clin Immunol. 2015 Feb 10. pii: S0091-6749(15)00021-4. doi: 10.1016/j.jaci.2014.12.1939. [Epub ahead of print] 29. Perez EE, et al. Use of intravenous immunoglobulin in human disease: A review of evidence by members of the Primary Immunodeficiency Committee of the American Academy of Allergy, Asthma and Immunology. In Press Dec 2016 (available on line, then in print Mar 2017). 30. Perez EE, Bonilla FA, Orange JS, Ballow M. Specific Antibody Deficiency: Controversies in Diagnosis and Management Frontiers in Immunology 2017 May 22. Vol 8. Article 586. doi: 10.3389/fimmu.2017.00586
RECENT ABSTRACTS
1. E. Perez, J. Riley, D. von Laer, C. June: HIV resistance in primary CD4 T cells engineered to express a gp-41 derived peptide. Oral presentation at the Fourth Annual FOCIS Meeting, Montreal, Canada 2004.
2. M. Heltzer, M. Paessler, N. Bunin, L. Raffini, E. Perez: Case report: reticular dysgenesis presenting with profound neutropenia. Poster at CIS Primary Immune Deficiency Disorders Consortium Conference, Boston, MA May 2005. (Published article in Journal of Allergy and Clinical Immunology October, 2007)
3. E. Perez, Y. Jouvenot, F. Urnov, M. Holmes, C. Beausejour, J. Rock, Y. Lee, J. Miller, D. Ando, P. Gregory, J. Riley, and C. June: Toward gene knock out therapy for HIV/AIDS. Poster at ICAAC Interscience Conference on Antimicrobial Agents and Chemotherapy 2005, Washington, D.C. 2005.
4. E. Perez, Y. Jouvenot, F. Urnov, M. Holmes, C. Beausejour, J. Rock, Y. Lee, J. Miller, D. Ando, P. Gregory, J. Riley, and C. June: Use of engineered zinc-finger-based endonucleases to create CCR5 targeted gene disruption in T Cells as potential therapy of HIV/AIDS. Poster Presentation at the 2005 12th Conference on Retroviruses and Opportunistic Infections, Boston, Massachusetts.
5. E. Perez, Y. Jouvenot, F. Urnov, M. Holmes, C. Beausejour, J. Rock Y. Lee, J. Miller, D. Ando, P. Gregory, J. Riley and C. June: Engineered zinc-finger nucleases for targeted disruption of CCR5 gene. Poster at Chemokines and Chemokine Receptors Keystone Symposia, Snowbird, Utah January 2006.
6. Y. Jouvenot, E Perez, F Urnov, J Miller, E Rebar, M Holmes, D Ando, J Riley, P Gregory, and C June. Toward gene knockout therapy for AIDS/HIV: Targeted disruption of ccr5 using engineered zinc finger protein nucleases. Oral Presentation at the 2006 13th Conference on Retroviruses and Opportunistic Infections, Denver, Colorado.
7. E. Perez, O. Liu, C. June: Engineered zinc finger nucleases for gene knock out therapy in cancer. Poster at the 9th Annual Meeting of the Regional Cancer Center Consortium for the Biological Therapy of Cancer, Pittsburgh, PA February 2006.
8. E. Perez, M. Suhoski, M. Heltzer, J. Orange: Monosomy 1p36 associated with immune deficiency and decreased expression of OX40. Oral presentation at the CIS Primary Immune Deficiency Disorders Consortium Conference, San Francisco 2006. (Published article in Clinical Immunology 2008)
9. E. Perez, Y. Jouvenot, F. Urnov, M. Holmes, C. Beausejour, J. Rock, Y. Lee, J. Miller, D. Ando, P. Gregory, J. Riley, and C. June: Towards gene knock out therapy for AIDS/HIV: targeted disruption of CCR5 using engineered zinc finger protein nucleases. Poster at the Annual ICAAC meeting, San Francisco 2006.
10. B. L. Levine, M. DeCaul, O. Liu, J. Wang, G. Lee, K. Kim, N. Wang, D. Ando, P. D. Gregory, J. L. Riley, M. C. Holmes, C.H. June, and E. Perez: Gene modification at clinical scale: engineering resistance to HIV Infection via targeted disruption of the HIV co-receptor CCR5 gene in CD4+ T cells using modified zinc finger protein nucleases. Poster at the International Society for Cellular Therapy meeting, 2007. Sydney, Australia.
11. E. Perez, J. Wang, O. Liu, Kenneth Kim, Nathaniel Wang, G. Lee, J. C. Miller, D. Guschin, V. Bartsevich, P. D. Gregory, J. L. Riley, M. C. Holmes and C.H. June. Targeted disruption of CCR5 using engineered zinc finger protein nucleases provides in vivo protection from HIV. Oral presentation during plenary at the American Society for Gene Therapy 10th Annual Meeting, Seattle. May 30 - June 3, 2007. Recipient, 4 Top Abstracts Award.
12. B.L. Levine, M. DeCaul, O. Liu, J. Wang, G. Lee, K. Kim, N. Wang, D. Ando, P.D. Gregory, J.L. Riley, M.C. Holmes, C.H. June, E. Perez. Gene modification at clinical scale: engineering resistance to HIV infection via targeted disruption of the HIV coreceptor CCR5 gene in CD4 T cells using zinc finger protein nucleases. Poster at the American Society for Gene Therapy, Boston 2008.
13. E. Perez, M. Dorsey, J. Sleasman, C. Walsh, B. Kirkpatrick, J. Romeo, R. Sanka. Elevated IL-8 levels in allergic airways inflammation is down regulated following aerosolized brevetoxin exposure. Poster at the American Academy of Allergy Asthma and Immunology annual meeting, New Orleans 2010.
14. M. Longley, A. Petrovic, E. Perez, J. Sleasman, M. Dorsey. The use of dihydrorhodamine testing to assess granulocyte function following hematopoietic stem cell transplantation for autosomal recessive chronic granulomatous disease. Florida Allergy Asthma and Immunology Society. June 2010.

15. L. Yin, L. Liu, Y. Cai, W. Hou, M. Wallet, B. Gardner, A. Lowe, Y. Sun, P, Sriaroon, E. Perez, C.A. Rodriguez, J.W. Sleasman and M.M. Goodenow. Mapping defects in IgM+ B cell repertoire in HIV-infected individuals by 454-pyrosequencing. AIDS Vaccine Conference, Georgia 2010.
16. D Nguyen, E Kellner, S Hudey, A Tyagi, MJ Dorsey, P Sriaroon, JW Sleasman, EE Perez. Elevation of Soluble CD14 Levels Support Chronic Innate Immune Activation in Subjects with CVID and SLE Compared to Healthy Subjects. Poster at the American Academy of Allergy Asthma and Immunology annual meeting, San Francisco 2011.
17. M M Longley, E Kellner, S Hudey, S Lukas, P Sriaroon, J W Sleasman, E E Perez, T Murphy, M J Dorsey Evidence of macrophage activation in Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections (PANDAs). Poster at the American Academy of Allergy Asthma and Immunology annual meeting, San Francisco 2011.
18. A. Elizalde, S. Hudey, M Dorsey, E. Perez, M. Goodenow, J Sleasman, P. Sriaroon. CD21-/low B cells are increased in both Common Variable Immunodeficiency and Specific Antibody Deficiency. Poster at the American Academy of Allergy Asthma and Immunology annual meeting, San Francisco 2011.
19. M. Dorsey, A Elizalde, E Perez, P Sriaroon, D Nguyen, R Lockey, J Sleasman. Effectiveness of an Educational Intensive Course on Allergy and Immunology Clinical and Diagnostic Procedures. Poster at the American Academy of Allergy Asthma and Immunology annual meeting, Orlando 2012
20. C Kubiak, J Sleasman, M Dorsey, E Perez. Financial Impact of Late Diagnosis of Severe Combined Immunodeficiency: Why it is fiscally sound for states to invest in the implementation of newborn screening for SCID. Oral abstract presented at the American Academy of Allergy Asthma and Immunology annual meeting, Orlando 2012.
21. Elena E. Perez, In utero hematopoietic stem cell transplant: A 17year follow up. Poster presented at the American Academy of Allergy Asthma and Immunology annual meeting, San Antonio 2013.
22. R McCormack, E. Szymanski, A. Hsu, K. Olivier, E Perez, E. Podack, S. M. Holland. Perforin-2 mutations in pulmonary nontuberculous mycobacterial infection, Oral abstract presented at the Clinical Immunology Society Meeting, Houston, 2015.
23. E. Perez, A. Koterba, M. Stein, B. Moskowitz, N. Rothschild. Modified Oral Rapid Drug Desensitization (ORDD) to Ibrutinib in a Patient with Stage IV Mantle Cell Lymphoma and Early Onset Grade 1 Hypersensitivity Reaction. Poster presented at American Academy of Allergy Asthma and Immunology annual meeting, Atlanta 2017.

BOOKS, BOOK CHAPTERS AND REVIEWS

1. Andrews T, and Perez E, "Inherited immune deficiencies," in Blueprints Pediatric Infectious Diseases, S. Shah, editor. Blackwell Publishing, 2005. p 170-177. (updated each edition)
2. Perez E, "Common variable immunodeficiency" in 5 Minute Pediatric Consult. W. Schwartz, et al. editors. Lippincott Williams & Wilkins 2006-present 3rd edition-7th edition. (updated each edition)
3. Perez E, "Wiskott Aldrich syndrome" in 5 Minute Pediatric Consult. W. Schwartz, et al, editors. Lippincott Williams & Wilkins 2006-present. 3rd edition -7th edition. (updated each edition)
4. Varela-Rohena A, Carpenito C, Perez E, et al. "Genetic Engineering of T cells for adoptive immunotherapy." Immunologic Research, 42 (1-3): 166-181 October 2008.
5. Routes J, Abinun M, Al-Herz W, Bustamante J, Condino-Neto A, DeLaMorena M, Etzioni A, Gambineri E, Haddad E, Kobrynski L, Le Deist F, Nonoyama S, Olivera J, Perez E, Picard C, Rezaei N, Sleasman J, Sullivan K, Torgerson T. ICON: the Early Diagnosis of Congenital Immunodeficiencies. Journal of Allergy and Clinical Immunology (submitted Aug 2013)
6. Perez, E. Chapter 59. Resources for clinicians. Immunologic Disorders in Infants and Children. Ed. Stiehm, Ochs, and Winkelstein, 6th edition.

MANUSCRIPTS IN PREPARATION Several book chapters to be included in: Encyclopedia of Medical Immunology. Editors: Ian Mackay, Noel R. Rose Jordan Scott Orange, Francisco A. Bonilla. Copyright 2019. Springer Verlag NY ISBN: 978-1-4614-8679-4.

INVITED PRESENTATIONS

2004 Mar 2005

Lecture, Future of treatment for primary Immunodeficiencies, Children's Hospital of Philadelphia, Primary Immunodeficiency: A Window of Opportunity for the Primary Care Provider, Philadelphia, Pennsylvania (CME Course). Lecture, "Gene Therapy: The future of treatment for primary immunodeficiencies" Thomas Jefferson University, Allergy/Immunology Rounds, Philadelphia, Pennsylvania

Feb 2006
May 2007
Jun 2007
Mar 2008
Mar 2008 Mar 2008 Apr 2008
Mar 2009 Sep 2009
Nov 2009
Jan 2010
Feb 2010 Feb 2010
May 2010
Sep 2010
Oct 2010
Mar 2011 Mar 2011 Apr 2011
Aug 2011
Dec 2011 Dec 2011
Dec 2011
Jan 2012
Mar 2012
Aug 2012
Sep 2012 Sep 2012
Oct 2012
Mar 2013 Apr 2013
Apr 2013

Lecture, Towards Gene Knock Out Therapy for AIDS/HIV: Targeted Disruption of CCR5 Using Engineered Zinc Finger Protein Nucleases, Conference on Retroviruses and Opportunistic Infections, Denver, Colorado Lecture, European Spring School in Regenerative Medicine. "Zinc finger technology for the treatment of HIV" Oslo, Norway Lecture, Genome editing using zinc finger nucleases: establishment of HIV resistance in primary CD4 T cells. University of South Florida, All Children's Hospital, St. Petersburg, Florida. Lecture, "Basic immunologic insights from HIV: what's new in 2008," AAAAI Annual Meeting, Philadelphia, Pennsylvania Moderator, "Immunodeficiency and Host Defense", AAAAI Annual Meeting, Philadelphia Panelist, "The patient with Recurrent Infections or PID", AAAAI Annual Meeting, Philadelphia Lecture, Center for Information and Study on Clinical Research Participation (CISCRP), 2nd Annual Philadelphia Aware for All Clinical Research Education Day, Philadelphia, Pennsylvania Lecture, "Gene therapy for immunodeficiency diseases," AAAAI Annual Meeting, Washington, DC Lecture, "Approach to food allergy in children," All Children's Hospital Practical Pediatrics (CME Program), Pasco County, Florida Lecture, St. Jude Lunch and Learn HIV session Teleconference for USF and St. Jude Hospital, "ZFN technology for treatment of HIV" St. Petersburg, Florida (teleconferenced to Tennessee). Lecture, "Laboratory testing and diagnosis of primary immunodeficiency disorders," Immune Deficiency Foundation, Miami Children's Hospital, Miami, Florida Lecture, "Immunoglobulin supplementation: IVIG and SCIG." AAAAI Annual Meeting, New Orleans, Louisiana Lecture, "T cell and combined immunodeficiency," University of South Florida, Allergy and Immunology Fellowship Program Lecture Series. St. Petersburg, Florida Lecture, "Toolbox for the allergy and immunology program: how do you teach primary immunodeficiency?" Clinical Immunology Society First North American Primary Immune deficiency National Conference. Philadelphia, Pennsylvania Pediatric Grand Rounds, University of South Florida, Tampa General Hospital, 22q11.2 deletion syndrome: "DiGeorge Syndrome" Revisited, Tampa Pediatric Grand Rounds, All Children's Hospital, 22q11.2 deletion syndrome: "DiGeorge Syndrome" Revisited, St. Petersburg Lecture, "Clinical Presentation of T and B cell Immunodeficiency Diseases" AAAAI Annual Meeting, San Francisco Lecture, "IVIG and SCIG Therapy for Primary Immunodeficiency Diseases" AAAAI Annual Meeting, San Francisco Lecture, "General Care for Persons with Primary Immunodeficiency Disease." Immune Deficiency Foundation, Patient Education Meeting, Tampa, Florida. Lecture, Zinc Finger Nuclease Technology for Treatment of HIV-1 and New Directions for Research in Primary Immune Disease. Clinical Research Meeting, University of Miami. Miami, Florida Lecturer. Treatment Options for Primary Immunodeficiency Diseases. World Allergy Organization. Cancun, Mexico. Lecturer. Primary Immunodeficiency Diseases of the Innate Immune System. World Allergy Organization. Cancun, Mexico. Lecturer. Diagnosis and Management of B and T cell Immunodeficiency Diseases. World Allergy Organization. Cancun, Mexico. Testimony on Newborn Screening for Severe Combined Immunodeficiency at the Genetics and Newborn Screening Program Advisory Council, Jacksonville, FL 32202 Discussion Leader, Advances in the Diagnosis and Management of Chronic Granulomatous Disease, AAAAI Annual Meeting, Orlando Pediatric Grand Rounds, University of Miami, "Update on Newborn Screening for Severe Combined Immune Deficiency (SCID), Coming soon to Florida", Miami Pediatric Noon Conference Series, University of Miami, "Anaphylaxis: Clinical Review and Management", Miami Lecturer, University of Miami Pediatric Clinical Research Forum, "An Overview: Research Topics in Immunology and Primary Immunodeficiency Diseases", Miami Pediatric Noon Conference Series, University of Miami, "Toolbox for the Diagnosis of Primary Immunodeficiency Diseases", Miami Speaker, "Everything you should know about IVIG and SCIG", AAAAI Annual Meeting, San Antonio. Speaker, "Tales from the Listserve: A baby with IPEX and Ventilator Dependence" Clinical Immunology Society Meeting, Miami Speaker, University of Miami Pediatric Clinical Research Forum, "Use of multi-viral specific T cell therapy in the setting of bone marrow transplantation" Miami

Nov 2013 Nov 2013
Mar 2014
Apr 2014
May 2014
May 2014
Nov 2014
Mar 2015 Feb 2015 Feb 2015 Mar 2016 Mar 2016 Mar 2016 Apr 2016
Jun 2016 Jul 2016 Jul 2016 Aug 2016
Aug 2016
Sep 2016
Nov 2016
Nov 2016 Jan 2017
Mar 2017
Jan 2018
Mar 2018
Mar 2018
Mar 2018 Mar 2018
Mar 2018

Speaker, "Approach to Treatment with Replacement Ig Therapy", ACAAI Annual Meeting, Baltimore. Speaker, "Managing Recurrent Infections in Primary Immunodeficiency", Immune Deficiency Foundation Patient Education Meeting, Fort Lauderdale Speaker, "When Should Bone Marrow Transplantation be Considered in Primary Immunodeficiency?" AAAAI Annual Meeting, San Diego Speaker, "Modelling Immunoglobulin Prioritization--A pathway to consensus" consultancy to CSL Behring, Interlaken, Switzerland Speaker, "Diagnostic and Therapeutic Approaches to Primary Immunodeficiency Diseases" Eastern Allergy Conference, Palm Beach Florida Speaker, "IVIG for Neuroimmune Disorders" Pediatrics & Developmental Neuroscience Branch National Institute of Mental Health Speaker, "Overview of Treatment Options for Primary Immunodeficiencies" Immune Deficiency Foundation Patient Education meeting, Fort Lauderdale Speaker, Pediatric Grand Rounds. "Food Allergies: an update and recent landmark studies" Miami Speaker, "Evaluating and Addressing Knowledge Gaps in PIDD" consultancy talk to CSL Behring, Atlanta Participant, "Global Immunodeficiency Expert Advisory Panel (ILEAP)" consultancy to Baxter, Houston Speaker, "Eczema as a sign of Immunodeficiency." AAAAI Los Angeles, CA Speaker, "Newborn Screening for SCID: What every Clinician should know." AAAAI, Los Angeles, CA Moderator, "Common Variable Immunodeficiency (CVID) from the Bench to the Bedside." AAAAI, Los Angeles, CA Panel Discussion: "Interpreting Vaccine Antibody Responses in PID: Update on Diagnostic Advances in Primary Immunodeficiency." Clinical Immunology Society Speaker, "Evaluation of Primary Immunodeficiency." Eastern Allergy Conference, Palm Beach, FL Speaker, "Evaluation of Recurrent Respiratory Infections from the Immunology Perspective." FAAIS, Orlando, FL Speaker, "Approaches to Diagnosis and Management of Specific Antibody Deficiency." FAAIS, Orlando, FL Speaker, "The Diagnostic Evaluation of Primary Immunodeficiency." Alabama Society of Allergy and Immunology 2016 37th Annual Review Course. Destin, AL Speaker, "The Use and Interpretation of Diagnostic Vaccines for Immunology." Alabama Society of Allergy and Immunology 2016 37th Annual Review Course. Destin, AL Speaker, "Vaccines: Understanding the Risks and Benefits." Immune Deficiency Foundation Education Meeting. Fort Lauderdale, FL Speaker, "Immunoglobulin Replacement: When, By what route, and how much?" ACAAI National Meeting, San Francisco, CA Speaker, "Optimizing Patient Care with Hizentra." Product theater, ACAAI National Meeting, San Francisco, CA Speaker, "Immunoglobulin Replacement Therapy: Overview and Treatment Recommendations." AllergyImmunology Grand Rounds, Winthrop University Hospital, New York Speaker, "New Developments for Individualizing IG Treatment in Patients With Primary Immunodeficiency Diseases (PIDD)" Symposium presented at AAAAI National Meeting, Atlanta, GA Speaker, "Non-infectious complications of CVID." Immune Deficiency Foundation Education Meeting. Fort Lauderdale, FL. Speaker, "Perspectives on Primary Immunodeficiency (PI): Shared Decision-Making for Personalized PI Management." Symposium at AAAAI. Hosted by Shire. Speaker, "Defining Success for Patients: Individualizing Treatment for Primary Immunodeficiency" Symposium at AAAAI. Hosted by CSL Behring Moderator, "Prescribing IgG for Immunodeficiency" Seminar Session 3004. AAAAI National Meeting, Orlando Moderator, "BCI: Mechanisms Underlying Incomplete Penetrance and Variable Presentation of Primary Immunodeficiency Disorders." Session 3702. AAAAI National Meeting, Orlando, FL Moderator, "Topics in Common Variable Immunodeficiency" Session 2602. AAAAI National Meeting, Orlando, FL

Speaker Bureau 2017-present Speaker Bureau for CSL Behring 2018-present Speaker Bureau for Genentech/Novartis

SERVICE
1991-1993 1992-1995 1993-1994 1996-1997
2001-2003 2001-2003 2010 2010
2010
2010
201220122014 2014-2015

University Committees
Student Representative, Medical Student Admissions Committee, University of Florida College of Medicine Class Representative, Curriculum Committee, University of Florida College of Medicine Student Representative, LCME Re-accreditation Committee, University of Florida College of Medicine Student Representative, Medical Student Admissions Committee, University of Florida College of Medicine
Member, Intern Selection Committee Children's Hospital of Philadelphia Fellow Representative, Graduate Medical Education Committee, Children's Hospital of Philadelphia Member, Infection Control Committee, All Children's Hospital Member, Fellow Selection Committee, University of South Florida Allergy/Immunology Fellowship Program, St. Petersburg Member, Faculty Research and Clinical Retreats, University of South Florida Allergy/Immunology Fellowship Programs Organizer, First Annual "Boot camp" Orientation for University of South Florida Fellowship Programs in Allergy and Immunology Member, Jackson Memorial Hospital, Transfusion Committee Member, University of Miami, Pediatric Executive Committee Organizer, Asthma Quality Improvement Project Holtz/UM Identified as University of Miami "core" teaching faculty by the Department of Pediatrics

1992 2005-2010 2006 2007-2008 2007-2009 2008 2009 2009 2009 2009-2011 2010 20112011 2011 2011 2012 2012, 2013 2012 2013 2012-present 2014 2014
2014
2014
2014-2016 2014 2015 2015 2015

Extramural Committees and Appointments Co-chair, Fifth Annual Health Care Issues Conference, University of Florida College of Medicine Chair, Committee for Development of Primary Immunodeficiency Educational Slide Set, AAAAI Moderator, Primary Immune Deficiency Workshop, AAAAI Annual Meeting, Miami, Florida Appointed Vice Chair, Primary Immunodeficiency Committee, AAAAI Member, Clinical Immunology Society Finance Committee Abstract Reviewer for the AAAAI Annual Meeting, Philadelphia Abstract Reviewer for the AAAAI Annual Meeting, Washington, DC Moderator, "Gene Therapy for Immunodeficiency," AAAAI Annual Meeting, Washington, DC Moderator, Oral Abstract Session, "Primary Immunodeficiency," Washington, DC Appointed Chair, Primary Immunodeficiency Committee, AAAAI Abstract Reviewer for the AAAAI Annual Meeting, New Orleans Member, AAAAI Website Review Panel Reviewer, Up-to-Date Reviewer, Frontiers in Immunology Abstract Reviewer, for the AAAAI Annual Meeting, San Francisco Abstract Reviewer, for the AAAAI Annual Meeting, Orlando Nomination for Directorship of the American Board of Allergy Asthma and Immunology Secretary, Basic and Clinical Immunology Interest Section, AAAAI Abstract Reviewer, for AAAAI Annual Meeting, San Antonio Member, Annual Meeting Program Committee, AAAAI Abstract Reviewer, for AAAAI Annual Meeting, San Diego Moderator, "Primary Immunodeficiency at the Molecular Level: The Wave of the Future" AAAAI Annual Meeting, San Diego Moderator, "Use of Gamma Globulin in Clinical Practice: Indications, Challenges, Adverse Reactions and Monitoring" AAAAI Annual Meeting, San Diego Moderator, Clinical Immunology Society Meeting, "Hot new Gene Defects associated with Primary Immunodeficiency", Baltimore Vice Chair, BCI interest section AAAAI Appointed to the State of Florida Newborn Screening Advisory Council Abstract Reviewer and Annual Meeting Program Committee, AAAAI Annual Meeting, Houston Appointed to the Clinical Immunology Society Council Abstract Reviewer and Annual Meeting Program Committee, AAAAI Annual Meeting, Los Angeles

2016 2017 2017-present

Abstract Reviewer and Annual Meeting Program Committee, AAAAI Annual Meeting, Atlanta Abstract Reviewer and Annual Meeting Program Committee, AAAAI Annual Meeting, Orlando Chair, BCI Interest Section, AAAAI

CLINICAL RESEARCH EXPERIENCE: · Clinical Investigator, "A Phase 3, Multicenter, Open-Label Study of the Safety, Tolerability, Efficacy, and Pharmacokinetics of ProMetic BioTherapeutics Immune Globulin Intravenous (Human) 10% in Adults and Children with Primary Immunodeficiency Diseases" · Clinical Investigator, "An open-label, multi-center study to evaluate the safety and pharmacokinetics of IGSC 20% administered for 6 months in subjects with primary immunodeficiency" · Clinical Investigator, "A Phase III, Multicenter, Open-Label Study to Evaluate the Pharmacokinetics and Safety of Subgam VF in Primary Immunodeficiency Disease (PID)" · Clinical Investigator, "Real-World AR101 Market-Supporting Experience Study in Peanut-Allergic Children Ages 4 to 17 Years (RAMSES)" Aimmune Therapeutics, Inc. protocol ARC007 · Clinical Investigator, "Open-Label, Single-Arm, Historically Controlled, Prospective, Multicenter Phase III Study to Evaluate the Safety, Efficacy and Pharmacokinetics of Immune Globulin Intravenous (Human) GC5107 in Subjects with Primary Humoral Immunodeficiency" · Clinical Investigator, "Prospective, Open Label, Multicenter Study of the Efficacy, Safety, Tolerability, and Pharmacokinetics of Therapure PlasmaCap IG in Adults and Children with Primary Immune Deficiency Diseases" · Clinical Investigator, "Comparison of Two Infusion Devices with Respect to Pharmacokinetics, Safety and Tolerability of Hizentra: An Investigational Wearable Infusor and the Crono S-PID-50 Infusion Pump" · Clinical Investigator, "Postmarking Requirement (PMR) Non-Interventional 2-Armed Study to Evaluate the Safety of Octagam Immune Globulin Intravenous (Human) 5% Liquid Preparation, with a Special Emphasis on Monitoring, Analysis and Reporting of Thromboembolic Events (TEEs)" · Clinical Investigator, "AN Open-Label, Single-Arm, Historically Controlled, Prospective, Multicenter, Phase III Study to Evaluate the Safety, Efficacy and Pharmacokinetics of Immune Globulin Intravenous (Human) IVIG-SN in Pediatric Subjects with Primary Humoral Immunodeficiency"