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740938 en-EN GHS

Safety Data Sheet
according to Regulations 1907/2006/EC (REACh) and 2015/830/EU

REF: 740938 Printing date: 28.05.2020

Buffer PW1 (125 mL) Date of issue: 20.05.2019

Page: 1/7

SECTION 1: Identification of the substance/mixture and of the company/undertaking

1.1

Product identifier

REF Product name

740938 Buffer PW1 (125 mL)

REACH Registration number(s): see SECTION 3.1/3.2 or
A registration number for the substance(s) does not exist because the annual tonnage does not require registration or
the substance or its use is excluded from registration.

1 x 125 mL PW1

1.2

Relevant identified uses of the substance or mixture and uses advised against

Relevant identified uses Product for analytical use.
Exposure Scenario Classification according REACh, RIP 3.2 Codes: SU 0-2, PC 21, PROC 15, AC 0 The exposure scenario is integrated into sections 1-16. Uses advised against not described

1.3

Details of the supplier of the safety data sheet

Manufactured by: MACHEREY-NAGEL GmbH & Co. KG Neumann-Neander-Str. 6-8, 52355 Dueren, GERMANY Tel.: +49 2421 969 0

E-mail: sds@mn-net.com (msds@mn-net.com)

1.4

Emergency telephone number

Outside Germany (DE): Call your regional Poisons Information Service or call local Life Saving Service.

DE: Gemeinsames Giftinformationszentrum (GGIZ)

99089 Erfurt tel. +49 361 730 730

You find our current versions of SDS (22 languages) in Internet:

http://www.mn-net.com/SDS

SECTION 2: Hazard identification

2.1

Classification of the substance or mixture

125 mL PW1

Signal word
Hazard identification
H226 H302 H319 H336, H335

GHS02 GHS07
WARNING
Hazard classes/categories
Flam. Liq. 3 Acute Tox. 4 oral Eye Irrit. 2 STOT SE 3

2.2

Label elements

According CLP directive inner packages must be only labelled with GHS symbol(s) and product identificator(s) (EU 1272/2008 Annex I - 1.5.1.2).

Harmful chemicals/mixtures with signal word: WARNING and highly flammable chemicals/mixtures must not be labelled with H and P phrases until 125 mL (EU 1272/2008 Annex I - 1.5.2). The irritant hazard should be eliminated, because of buffer chemicals inside.

Version: M V 4.10.1

Safety Data Sheet
according to Regulations 1907/2006/EC (REACh) and 2015/830/EU

REF: 740938 Printing date: 28.05.2020

Buffer PW1 (125 mL) Date of issue: 20.05.2019

125 mL PW1

Page: 2/7

GHS02 GHS07 Signal word: WARNING

2.3

Other hazards

Possible hazards from physicochemical properties In the case of pH values are less than 5 or higher than 9 then it is irritant. Flammable properties. ---
Information pertaining to particular risks to human and possible symptoms Cause after oral intake, impairments of health when ingested in small quantities. ---
Information pertaining to particular risks to the environment ---
Other hazards ---

SECTION 3: Composition/information on ingredients

3.1

Substances or 3.2 Mixtures

125 mL PW1

Chemical: guanidine hydrochloride

CAS No.: 50-01-1

Classification:

H302, Acute Tox. 4 oral, H315, Skin Irrit. 2, H319, Eye Irrit. 2

Formula:

CH6 ClN3

Pseudonym:

guanidinium chloride

TSCA Inventory: listed

REACH Reg. No.: 01-2119977063-35-0005

EC No.:

200-002-3

Indice No.:

607-148-00-0

RTECS:

MF4300000

MFCD:

00013026

KE No.:

KE-18111

Concentration:

36 - <50 %

acc. CLP (GHS): H302, Acute Tox. 4 oral, H319, Eye Irrit. 2

Chemical: 2-propanol

Classification:

H225, Flam. Liq. 2, H319, Eye Irrit. 2, H336, STOT SE 3

Formula:

C3 H8 O

Pseudonym:

isopropanol, IPA, propan-2-ol

TSCA Inventory: listed

REACH Reg. No.: 01-2119457558-25-XXXX

EC No.:

200-661-7

Indice No.:

RTECS:

NT8050000

MFCD:

KE No.:

KE-29363

Concentration:

20 - <35 %

acc. CLP (GHS): H226, Flam. Liq. 3, H319, Eye Irrit. 2, H336, STOT SE 3

CAS No.: 67-63-0
603-117-00-0 00011674

3.3

Remarks

When not listed, mixtures are added with water [CAS No. 7732-18-5] to 100%.

List of H and P phrases: see section 16.1

SECTION 4: First aid measures

4.1
4.1.1

Description of first aid measures
Place insured person out of danger zone to fresh air immediately. Ensure quiet, warmth, and provide resuscitation if necessary. If necessary contact medical advice.
After SKIN Contact Remove contaminated clothing. Rinse the affected skin or mucous membrane thoroughly under running water. (If possible) use soap.

Version: M V 4.10.1

Safety Data Sheet
according to Regulations 1907/2006/EC (REACh) and 2015/830/EU

REF: 740938 Printing date: 28.05.2020

Buffer PW1 (125 mL) Date of issue: 20.05.2019

Page: 3/7

4.1.2
4.1.3 4.1.4
4.2 4.3

After EYE Contact After contact with the eyes rinse thoroughly under running water with the eyelid wide open with eye washing bottle, eye douche or running water (protect intact eye).
After INHALATION of vapours After inhalation of foam or vapour fresh air should be inhaled. Keep airways free. ---
After ORAL Intake After oral intake lots of water should be drunk after it has been ingested. ---
Most important symptoms and effects, both acute and delayed
---
Indication of any immediate medical attention and special treatment needed
No additionally recommendations. ---

SECTION 5: Firefighting measures

5.1

Extinguishing media

Fire extinguishers appropriate to the fire classification, and, if applicable, a fire blanket must be available in a prominent location in the work area. All extinguishers like FOAM, WATER SPRAY, DRY POWDER, CARBON DIOXIDE can be used.

5.2

Special hazards arising from the substance or mixture

WARNING: Flammable (GHS regulation). May form explosive vapour-air mixtures. Formation of hazardous and caustic vapour-air mixtures possible. ---

5.3

Advice for firefighters

No, for listed product. Product package burns like paper or plastic.

5.4

Additional information

---

SECTION 6: Accidental release measures

6.1

Personal precautions, protective equipment and emergency procedures

Do not breathe vapours. Regular staff training is necessary.

6.2

Environmental precautions

not necessary

6.3

Methods and material for containment and cleaning up

Bind any escaping liquid with inert absorbent. Collect small amounts of leaked liquid and flush with water into drains.

6.4

Reference to other sections

---

SECTION 7: Handling and storage

7.1 7.2
7.2.1
7.3

Precautions for safe handling
Handling in accordance with the test instruction, that comes with the product.

Conditions for safe storage, including any incompatibilities

The original product package of MACHEREY-NAGEL allows a safe storage.

Storage class (VCI):

Water hazard class (DE):

Requirements for stock rooms and containers Keep original product packages tightly closed during handling and storage.

Specific end use(s)
Product for analytical use.

Version: M V 4.10.1

Safety Data Sheet
according to Regulations 1907/2006/EC (REACh) and 2015/830/EU

REF: 740938 Printing date: 28.05.2020

Buffer PW1 (125 mL) Date of issue: 20.05.2019

SECTION 8: Exposure controls/personal protection

8.1

Control parameters

125 mL PW1

Chemical: guanidine hydrochloride

DNEL:

[inh] 3.5 mg/m³

DNEL = Derived No-Effect Level (for workers)

CAS No.: 50-01-1

PNEC(fresh water) :

PNEC = Predicted No Effected Concentration

NIOSH:

not listed

[TWA] Time-weighted average to a reference period of 8 hours, [STEL] Short-term exposure limit related to a 15-minute period

OSHA:

not listed

Chemical: 2-propanol

DNEL:

[inh] 500 mg/m³

DNEL = Derived No-Effect Level (for workers)

CAS No.: 67-63-0

PNEC(fresh water) :

140.9 mg/L

PNEC = Predicted No Effected Concentration

TRGS 900 (DE):

200 ppm / 500 mg/m³
E/e respirable

Short-term exposure factor: 2 (II), Y
skin resorptive (H), respiratory sensitizable (Sa), skin sensitizable (Sh), teratogenic (Z) not securely excluded / (Y) certainly excluded

SUVA(CH) MAK value: TRGS 903 (DE):

200 ppm / 500 mg/m³
[Aceton B/b, U/b] 25 mg/L
B blood, U urine, a no limitation, b end of exposition or shift

NIOSH:

[TWA] 400 ppm / 980 mg/m³

NIOSH STEL:

500 ppm / 1225 mg/m³

[TWA] Time-weighted average to a reference period of 8 hours, [STEL] Short-term exposure limit related to a 15-minute period

OSHA:

[TWA] 400 ppm / 980 mg/m³

Page: 4/7

8.2
8.2.1 8.2.2 8.2.3 8.2.4 8.2.5

Exposure controls
Good ventilation and extraction system in the room, floor resistant to chemicals with floor drainage and washing facilities. The highest level of cleanliness must be maintained at the workplace.
Respiratory protection No additional recommendations.
Hand protection Yes, gloves according EN 374 (permeation time >30 min - level 2), consist of PVC (f.ex. from Ansell or KCL).
Eye protection Yes, safety glasses according EN 166 with integrated side shields or wrap-around protection.
Skin protection Not necessary.
Personal hygiene Eating, drinking, smoking, taking snuff and storage of food in work areas and at outdoor workplaces is prohibited. Avoid contact with the skin, eyes and clothing. Rinse any clothing on which the substance has been spilled, and soak it in water. Wash hands thoroughly with soap and water when stopping work and before eating, and then apply protective skin cream.

SECTION 9: Physical and chemical properties

9.1

Information on basic physical and chemical properties

125 mL PW1 Appearance: liquid pH: Flash point: Specific gravity:

Colour: colourless 7-8 25 °C 1.06 g/cm³

Odor: alcoholic

9.2

Other information

Data for the other parameters of the mixtures are not available, because no registration and no chemical safety report is required. Relevant Properties of Substance Group ---

Version: M V 4.10.1

Safety Data Sheet
according to Regulations 1907/2006/EC (REACh) and 2015/830/EU

REF: 740938 Printing date: 28.05.2020

Buffer PW1 (125 mL) Date of issue: 20.05.2019

Page: 5/7

SECTION 10: Stability and reactivity

10.1 10.2 10.3 10.4 10.5 10.6

Reactivity
no further data available.
Chemical stability
No known instability.
Possibility of hazardous reactions
Note: Can form very reactive substances with oxidizing agents. No further data available.
Conditions to avoid
---
Incompatible materials
Avoid contact with strong acids or alkalines.
Hazardous decomposition products
In the original package all parts/all reagents are safety and separated stored. Decompositions are not observed during the expiration period under recommended conditions.

SECTION 11: Toxicological information

11.1

Information on toxicological effects

Following information is valid for pure substances. Quantitative data on the toxicity of this product are not available.

125 mL PW1

Chemical:

guanidine hydrochloride

CAS No.: 50-01-1

TSCA Inventory:

listed

California Proposition 65 List: not listed

Australia NICNAS:

not listed

Canada CEPA 1999: DSL yes

Japan CSCL/PRTR:

not listed, Japan PDSCL: not listed

Japan ISHL:

not listed

South Korea TCCA:

not listed

Korea Exist.Chem.Inventory: KE-18111

LD50orl rat :

475-907 mg/kg

LC50ihl rat :

[4h] 3181-7655 µg/m³

LD50drm rbt :

2000 mg/kg

Acute Effects: Cause after oral intake, impairments of health when ingested in small quantities.

Chemical:

2-propanol

CAS No.: 67-63-0

TSCA Inventory:

listed

California Proposition 65 List: not listed

ACGIH:

1230 ppm

Exposure Routes:

inhalation, ingestion, skin and/or eye contact

Target Organs:

Eyes, skin, respiratory system

Symptoms:

irritation eyes, nose, throat; drowsiness, dizziness, headache; dry cracking skin; in animals: narcosis

Australia NICNAS:

Canada CEPA 1999: DSL yes

Japan CSCL/PRTR:

PAC yes, Japan PDSCL: -

Japan ISHL:

listed 1,0%/0,1%, Article 57-2 (SDS required)

South Korea TCCA:

Korea Exist.Chem.Inventory: KE-29363

LD50orl rat :

5045 mg/kg

LC_Loworl hmn :

3570 mg/kg

LC50ihl rat :

164h g/m³

LD50drm rbt :

12.8 g/kg

TRGS 905 (DE):

RF C

SECTION 12: Ecological information

12.1

Toxicity
Following information is valid for pure substances.

125 mL PW1

Chemical:

guanidine hydrochloride

PNEC(fresh water) :

PNEC = Predicted No Effected Concentration

LC50leuciscus idus/96h : LC50fish/96h :

1759 mg/L [4d] 690-1850; [48h] 1758-2420 mg/L

CAS No.: 50-01-1

Version: M V 4.10.1

Safety Data Sheet
according to Regulations 1907/2006/EC (REACh) and 2015/830/EU

REF: 740938 Printing date: 28.05.2020

Buffer PW1 (125 mL) Date of issue: 20.05.2019

Page: 6/7

EC50daphnia/48h : EC10pseudomonas putita/16h : Water hazard class (DE):
Storage class (VCI):

70.2 mg/L

[72h] 11.8-33.5 mg/L

WGK No.: 0788

Chemical:

2-propanol

PNEC(fresh water) :

140.9 mg/L

PNEC = Predicted No Effected Concentration

LC50fish/96h : EC50daphnia/48h : IC50scenedesmus quadricauda/72h : EC10pseudomonas putita/16h : Water hazard class (DE):
Dispersion coefficient(octanol-water) : Storage class (VCI):

1400 mg/L

13.3 g/L

>1000 mg/L

EC5: 1050 mg/L

WGK No.: 0135

0.05

CAS No.: 67-63-0

12.2 12.3 12.4 12.5 12.6

Persistence and degradability
not necessary
Bioaccumulative potential
not necessary
Mobility in soil
not necessary
Results of PBT and vPvB assessment
no data available
Other adverse effects
no additional data available

SECTION 13: Disposal considerations

Please observe local regulations for collection and disposal of hazardous waste and contact waste disposal company, where you will obtain information on laboratory waste disposal (waste code number 16 05 06).

13.1

Waste treatment methods
Normally it is possible to empty small amounts (diluted!) into drains.

SECTION 14: Transport information

14.1 UN number: 14.3 Class: Road transport Classification code: Limited Quantity: Excepted Quantity: Air transport PAX: CAO: Maritime transport EmS:

1993 14.2

14.4

F1 5 L E 1

355 366

F-E, S-E

UN proper shipping name: Flammable liquid, n.o.s. (2-propanol mixture) Packing group: III

Tunnel restriction code:

Special instructions: 640E

max. weight PAX: 60 L max. weight CAO: 220 L

Storage category: A

14.5 14.6 14.7

Environmental hazards
none, contains only small quantities of hazardous substances
Special precautions for user
not necessary
Transport in bulk according to Annex II of MARPOL and the IBC Code
not applicable

Version: M V 4.10.1

Safety Data Sheet
according to Regulations 1907/2006/EC (REACh) and 2015/830/EU

REF: 740938 Printing date: 28.05.2020

Buffer PW1 (125 mL) Date of issue: 20.05.2019

Page: 7/7

SECTION 15: Regulatory information

15.1 15.2

Safety, health and environmental regulations/legislation specific for the substance or mixture
German act governing protection from hazardous substances (Chemicals Act / Chemikaliengesetz- ChemG), revised on August 2013 German order governing protection from hazardous substances (Ordinance on Hazardous Substances / Gefahrstoffverordnung GefStoffV), revised on November 2010, according to Directive 98/24/EC TRGS 200, German engineering rules governing the classification and labelling of hazardous substances, preparations and products, updated October 2011 MN Leaflet/User manual, also see www.mn-net.com Look for your country-specific regulations.
Chemical safety assessment
not necessary for these small amounts ---

SECTION 16: Other information

16.1
16.1.1 16.1.2
16.2 16.3 16.4
16.5

List of H and P phrases

List of relevant H phrases

H226

Flammable liquid and vapour.

H302

Harmful if swallowed.

H319

Causes serious eye irritation.

H336

May cause drowsiness or dizziness.

List of relevant P phrases

P210

Keep away from heat/sparks/open flames/hot surfaces. No smoking.

P260D

Do not breathe vapours.

P264W

Wash with water thoroughly after handling.

P280sh

Wear protective gloves/eye protection.

P301+312

IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell.

P330

Rinse mouth.

Training advice
Regular safety training.

Recommended restriction on use
Only for professional user. An individual package of this product or test kit has a moderate hazardous potential.

Further information
MACHEREY-NAGEL GmbH & Co. KG provides the information contained herein in good faith being up-to-date of own realizations at revision time. This document is intended only as a guide to the appropriate precautionary handling of the material by a properly trained person using this product. Individuals receiving the information must exercise their independent judgement in determining its appropriateness for a particular purpose. MACHEREY-NAGEL GmbH & Co. KG makes NO REPRESENTATIONS or WARRANTIES, either expressed or implied, including without limitation any warranties of merchantability, fitness for a particular purpose with respect to the information set forth herein or the product to which the information refers. Accordingly MACHEREY-NAGEL GmbH & Co. KG will not be responsible for damages resulting from use of or reliance upon this information. See terms and conditions at the end of our price lists for additional information.

Sources of key data

Regulation 453/2010/EU REACH - REQUIREMENTS FOR THE COMPILATION OF SAFETY DATA SHEETS

Regulation 487/2013/EU, 4th adaptation of CLP regulation to technical and scientific progress

Regulation 669/2018/EU, 4th adaptation of CLP regulation to technical and scientific progress

Regulation 1480/2018/EU, 4th adaptation of CLP regulation to technical and scientific progress

TRGS 900, German engineering rules governing limits in air at work, updated 03/2019

SUVA .CH, Limits in air at work 2009, revised on 01.2009

KÜHN, BIRETT

Merkblätter Gefährliche Arbeitsstoffe (Data Sheets of Hazardous Substances)

Revisions/Updates Reason for Revision: 2016-03 Adaptation of regulation 1221/2015/EU
2017-11 Adaption of ECHA Registration dossier

Version: M V 4.10.1

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