V6450(MLK2 Kinase Enzyme System)US(EN)
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v6450 ?la=en-us 09/16/2020
Product code
V6450
Components: Turnkey1 Turnkey5 Turnkey4 Turnkey10
Kit Components Description
MLK2 Kinase Enzyme System
Active Enzyme Kinase Substrate 5x Reaction Buffer A 0.1M DTT
Printing date 09/16/2020
Safety Data Sheet
acc. to OSHA HCS
Page 1/7 Reviewed on 07/26/2020
* 1 Identification
Product identifier Trade name: Active Enzyme
Article number: Turnkey1 Application of the substance / the mixture For Laboratory Use
Details of the supplier of the safety data sheet Manufacturer/Supplier:
Promega Corporation 2800 Woods Hollow Road Madison, WI 53711 U.S.A. 1-800-356-9526 or (608)-274-4330
Information department: SDS author: ChemicalRegulatory@promega.com Promega Corporation 2800 Woods Hollow Road Madison, WI 53711 U.S.A. 1-800-356-9526 or (608)-274-4330 Emergency telephone number: For Chemical Emergency Spill, Leak, Fire, Exposure, or Accident Call CHEMTREC Day or Night Within USA and Canada: 1-800-424-9300 Outside USA and Canada: +1 703-527-3887 (collect calls accepted)
* 2 Hazard(s) identification
Classification of the substance or mixture The product is not classified as hazardous according to the Globally Harmonized System (GHS).
Label elements GHS label elements Not applicable Hazard pictograms Not applicable Signal word Not applicable Hazard statements Not applicable Classification system: NFPA ratings (scale 0 - 4) Health = 0 Fire = 1 Reactivity = 0 HMIS-ratings (scale 0 - 4) Health = 1 Fire = 1 Reactivity = 0 OSHA Hazard Overview (Criteria according to 29CFR1910.1200): Not applicable Target Organ(s): May cause Kidney damage (Nephrotoxin)
(Contd. on page 2)
US
51.1.1
Printing date 09/16/2020 Trade name: Active Enzyme
Safety Data Sheet
acc. to OSHA HCS
Other hazards
Results of PBT and vPvB assessment PBT: Not applicable. vPvB: Not applicable.
Page 2/7 Reviewed on 07/26/2020
(Contd. of page 1)
* 3 Composition/information on ingredients
Chemical characterization: Mixtures Description: The product is made up of a mixture of non-hazardous components. The exact concentration percentages and
components name may be withheld as a Promega Corp. trade secret.
Dangerous components:
56-81-5 glycerol
20-25%
Additional information: For the wording of the listed risk phrases refer to section 15.
* 4 First-aid measures
Description of first aid measures General information: No special measures required. After inhalation: If the patient feels unwell or is concerned, obtain medical advice. After skin contact: Generally the product does not irritate the skin. After eye contact: Rinse opened eye for several minutes under running water. After swallowing: If the patient feels unwell or is concerned, obtain medical advice. Information for doctor: Most important symptoms and effects, both acute and delayed None No further relevant information available. Indication of any immediate medical attention and special treatment needed No further relevant information available.
* 5 Fire-fighting measures
Extinguishing media Suitable extinguishing agents: CO2, extinguishing powder or water spray. Fight larger fires with water spray or alcohol resistant foam. Special hazards arising from the substance or mixture None known No further relevant information available. Advice for firefighters No special advice Protective equipment: No special measures required.
* 6 Accidental release measures
Personal precautions, protective equipment and emergency procedures Not required. Environmental precautions: Dilute with plenty of water. Do not allow to enter sewers/ surface or ground water.
Methods and material for containment and cleaning up: Absorb with liquid-binding material (sand, diatomite, acid binders, universal binders, sawdust).
(Contd. on page 3)
US
51.1.1
Printing date 09/16/2020 Trade name: Active Enzyme
Safety Data Sheet
acc. to OSHA HCS
Reference to other sections No dangerous substances are released.
See Section 7 for information on safe handling.
See Section 13 for disposal information.
Page 3/7 Reviewed on 07/26/2020
(Contd. of page 2)
* 7 Handling and storage
Handling: Precautions for safe handling No special measures required. Information about protection against explosions and fires: No special measures required.
Conditions for safe storage, including any incompatibilities Storage: Requirements to be met by storerooms and receptacles: No special requirements. Information about storage in one common storage facility: Not required. Further information about storage conditions: None. Specific end use(s) No further relevant information available.
* 8 Exposure controls/personal protection
Control parameters
Components with limit values that require monitoring at the workplace:
56-81-5 glycerol
PEL Long-term value: 15* 5** mg/m³ mist; *total dust **respirable fraction
TLV TLV withdrawn-insufficient data human occup. exp.
Additional information: The lists that were valid during the creation were used as basis.
Exposure controls Personal protective equipment: General protective and hygienic measures: The usual precautionary measures for handling chemicals should be followed. Breathing equipment: Not required. Protection of hands: Not required. Material of gloves The selection of the suitable gloves does not only depend on the material, but also on further marks of quality and varies from manufacturer to manufacturer. As the product is a preparation of several substances, the resistance of the glove material can not be calculated in advance and has therefore to be checked prior to the application. Eye protection: Not required.
* 9 Physical and chemical properties
Information on basic physical and chemical properties
General Information
Appearance:
Form:
Fluid
Color:
Colorless
Odor:
Not determined
Odor threshold:
Not determined.
(Contd. on page 4)
US
51.1.1
Printing date 09/16/2020 Trade name: Active Enzyme
Safety Data Sheet
acc. to OSHA HCS
Page 4/7 Reviewed on 07/26/2020
Change in condition Melting point/Melting range: Boiling point/Boiling range:
Flash point:
Undetermined. 100 °C (212 °F) > 100 °C (> 212 °F)
Flammability (solid, gaseous):
Not applicable.
Ignition temperature: Decomposition temperature:
400 °C (752 °F) Not determined.
Auto igniting:
Product is not selfigniting.
Danger of explosion: Explosion limits:
Lower: Upper: Vapor pressure at 20 °C (68 °F):
Product does not present an explosion hazard.
0.9 Vol % 0.0 Vol % 0.1 hPa
Density:
Not determined.
Relative density
Not determined.
Vapor density
Not determined.
Evaporation rate
Not determined.
Solubility in / Miscibility with
Water:
Fully miscible.
Partition coefficient (n-octanol/water): Not determined.
Viscosity:
Dynamic:
Not determined.
Kinematic:
Not determined.
Organic solvents: Water: VOC content:
25.0 % 73.0 % 0.00 %
Solids content: Other information
1.7 % No further relevant information available.
(Contd. of page 3)
* 10 Stability and reactivity
Reactivity No further relevant information available. Chemical stability Thermal decomposition / conditions to be avoided: No decomposition if used according to specifications. Possibility of hazardous reactions No dangerous reactions known. Conditions to avoid No further relevant information available. Incompatible materials: No further relevant information available. Hazardous decomposition products: No dangerous decomposition products known.
* 11 Toxicological information
Information on toxicological effects Acute toxicity: LD/LC50 values that are relevant for classification: No data available Primary irritant effect: on the skin: No irritant effect. on the eye: No irritating effect.
(Contd. on page 5)
US
51.1.1
Printing date 09/16/2020 Trade name: Active Enzyme
Safety Data Sheet
acc. to OSHA HCS
Page 5/7 Reviewed on 07/26/2020
(Contd. of page 4)
Sensitization: No sensitizing effects known. Additional toxicological information: The product is not subject to classification according to internally approved calculation methods for preparations:
Carcinogenic categories IARC (International Agency for Research on Cancer) None of the ingredients are listed.
NTP (National Toxicology Program) None of the ingredients are listed.
OSHA-Ca (Occupational Safety & Health Administration) None of the ingredients are listed.
* 12 Ecological information
Toxicity Aquatic toxicity: Not available No further relevant information available. Persistence and degradability Not available No further relevant information available. Bioaccumulative potential Not known No further relevant information available. Mobility in soil No further relevant information available. Ecotoxicological effects: Remark: Not available Additional ecological information: General notes: Not known to be hazardous to water. Results of PBT and vPvB assessment PBT: Not applicable. vPvB: Not applicable. Other adverse effects No further relevant information available.
* 13 Disposal considerations
Waste treatment methods Recommendation: Disposal should be in accordance with applicable regional, national and local laws and regulations. Refer to Section 7: Handling and Storage and Section 8: Exposure Control/Personal Protection for additional handling information and protection of employees.
Uncleaned packagings: Recommendation: Disposal must be made according to official regulations. Recommended cleansing agent: Water, if necessary with cleansing agents.
* 14 Transport information
UN-Number
Not hazardous for transportation
(Contd. on page 6)
US
51.1.1
Printing date 09/16/2020 Trade name: Active Enzyme
Safety Data Sheet
acc. to OSHA HCS
DOT, ADR, ADN, IMDG, IATA
Not applicable
UN proper shipping name DOT, ADR, ADN, IMDG, IATA
None Not applicable
Transport hazard class(es)
None
DOT, ADR, ADN, IMDG, IATA Class
Not applicable
Packing group DOT, ADR, IMDG, IATA
None Not applicable
Environmental hazards:
Marine pollutant:
No
Special precautions for user
Not applicable.
Transport in bulk according to Annex II of
MARPOL73/78 and the IBC Code
Not applicable.
UN "Model Regulation":
Not applicable
Page 6/7 Reviewed on 07/26/2020
(Contd. of page 5)
* 15 Regulatory information
Safety, health and environmental regulations/legislation specific for the substance or mixture Sara Section 355 (extremely hazardous substances): None of the ingredients are listed.
Section 313 (Specific toxic chemical listings): None of the ingredients are listed.
TSCA (Toxic Substances Control Act) Inventory: 56-81-5 glycerol
Hazardous Air Pollutants None of the ingredients are listed. Proposition 65 Chemicals known to cause cancer: None of the ingredients are listed.
Chemicals known to cause reproductive toxicity for females: None of the ingredients are listed.
Chemicals known to cause reproductive toxicity for males: None of the ingredients are listed.
Chemicals known to cause developmental toxicity: None of the ingredients are listed.
Cancerogenity categories EPA (Environmental Protection Agency) None of the ingredients are listed.
TLV (Threshold Limit Value established by ACGIH) None of the ingredients are listed.
(Contd. on page 7)
US
51.1.1
Printing date 09/16/2020 Trade name: Active Enzyme
Safety Data Sheet
acc. to OSHA HCS
Page 7/7 Reviewed on 07/26/2020
NIOSH-Ca (National Institute for Occupational Safety and Health) None of the ingredients are listed. GHS label elements Not applicable Signal word Not applicable Hazard statements Not applicable
National regulations: No information available
Water hazard class: Water hazard class 1 (Self-assessment): slightly hazardous for water. Chemical safety assessment: A Chemical Safety Assessment has not been carried out.
(Contd. of page 6)
16 Other information
This information is based on our present knowledge. However, this shall not constitute a guarantee for any specific product features and shall not establish a legally valid contractual relationship.
Department issuing SDS: Promega Corporation Chemical Regulatory Department 2800 Woods Hollow Road Madison, WI Ph:(608)274-4330 Date of preparation / last revision 09/16/2020 / 1.0 Abbreviations and acronyms:
RID: Règlement international concernant le transport des marchandises dangereuses par chemin de fer (Regulations Concerning the International Transport of Dangerous Goods by Rail) ADR: Accord européen sur le transport des marchandises dangereuses par Route (European Agreement concerning the International Carriage of Dangerous Goods by Road) IMDG: International Maritime Code for Dangerous Goods DOT: US Department of Transportation IATA: International Air Transport Association ACGIH: American Conference of Governmental Industrial Hygienists EINECS: European Inventory of Existing Commercial Chemical Substances ELINCS: European List of Notified Chemical Substances CAS: Chemical Abstracts Service (division of the American Chemical Society) NFPA: National Fire Protection Association (USA) HMIS: Hazardous Materials Identification System (USA) VOC: Volatile Organic Compounds (USA, EU) LC50: Lethal concentration, 50 percent LD50: Lethal dose, 50 percent PBT: Persistent, Bioaccumulative and Toxic vPvB: very Persistent and very Bioaccumulative NIOSH: National Institute for Occupational Safety OSHA: Occupational Safety & Health TLV: Threshold Limit Value PEL: Permissible Exposure Limit REL: Recommended Exposure Limit
* Data compared to the previous version altered.
US
51.1.1
Printing date 09/16/2020
Safety Data Sheet
acc. to OSHA HCS
Page 1/7 Reviewed on 07/26/2020
* 1 Identification
Product identifier Trade name: Kinase Substrate
Article number: Turnkey5 Application of the substance / the mixture For Laboratory Use
Details of the supplier of the safety data sheet Manufacturer/Supplier:
Promega Corporation 2800 Woods Hollow Road Madison, WI 53711 U.S.A. 1-800-356-9526 or (608)-274-4330
Information department: SDS author: ChemicalRegulatory@promega.com Promega Corporation 2800 Woods Hollow Road Madison, WI 53711 U.S.A. 1-800-356-9526 or (608)-274-4330 Emergency telephone number: For Chemical Emergency Spill, Leak, Fire, Exposure, or Accident Call CHEMTREC Day or Night Within USA and Canada: 1-800-424-9300 Outside USA and Canada: +1 703-527-3887 (collect calls accepted)
* 2 Hazard(s) identification
Classification of the substance or mixture The product is not classified as hazardous according to the Globally Harmonized System (GHS).
Label elements GHS label elements Not applicable Hazard pictograms Not applicable Signal word Not applicable Hazard statements Not applicable Classification system: NFPA ratings (scale 0 - 4) Health = 0 Fire = 0 Reactivity = 0 HMIS-ratings (scale 0 - 4) Health = 0 Fire = 0 Reactivity = 0 OSHA Hazard Overview (Criteria according to 29CFR1910.1200): Not applicable Target Organ(s): Not applicable or unknown
(Contd. on page 2)
US
51.1.1
Printing date 09/16/2020 Trade name: Kinase Substrate
Safety Data Sheet
acc. to OSHA HCS
Other hazards
Results of PBT and vPvB assessment PBT: Not applicable. vPvB: Not applicable.
Page 2/7 Reviewed on 07/26/2020
(Contd. of page 1)
* 3 Composition/information on ingredients
Chemical characterization: Mixtures Description: The product is made up of a mixture of non-hazardous components. The exact concentration percentages and components name may be withheld as a Promega Corp. trade secret.
Dangerous components: Not applicable Additional information: For the wording of the listed risk phrases refer to section 15.
* 4 First-aid measures
Description of first aid measures General information: No special measures required. After inhalation: If the patient feels unwell or is concerned, obtain medical advice. After skin contact: Generally the product does not irritate the skin. After eye contact: Rinse opened eye for several minutes under running water. After swallowing: If the patient feels unwell or is concerned, obtain medical advice. Information for doctor: Most important symptoms and effects, both acute and delayed None No further relevant information available. Indication of any immediate medical attention and special treatment needed No further relevant information available.
* 5 Fire-fighting measures
Extinguishing media Suitable extinguishing agents: CO2, extinguishing powder or water spray. Fight larger fires with water spray or alcohol resistant foam. Special hazards arising from the substance or mixture None known No further relevant information available. Advice for firefighters No special advice Protective equipment: No special measures required.
* 6 Accidental release measures
Personal precautions, protective equipment and emergency procedures Not required. Environmental precautions: Dilute with plenty of water.
Methods and material for containment and cleaning up: Absorb with liquid-binding material (sand, diatomite, acid binders, universal binders, sawdust).
Reference to other sections No dangerous substances are released.
See Section 7 for information on safe handling.
(Contd. on page 3)
US
51.1.1
Printing date 09/16/2020 Trade name: Kinase Substrate
Safety Data Sheet
acc. to OSHA HCS
See Section 13 for disposal information.
Page 3/7 Reviewed on 07/26/2020
(Contd. of page 2)
* 7 Handling and storage
Handling: Precautions for safe handling No special measures required. Information about protection against explosions and fires: The product is not flammable.
Conditions for safe storage, including any incompatibilities Storage: Requirements to be met by storerooms and receptacles: No special requirements. Information about storage in one common storage facility: Not required. Further information about storage conditions: None. Specific end use(s) No further relevant information available.
* 8 Exposure controls/personal protection
Control parameters Components with limit values that require monitoring at the workplace: The product does not contain any relevant quantities of materials with critical values that have to be monitored at the workplace. Additional information: The lists that were valid during the creation were used as basis.
Exposure controls Personal protective equipment: General protective and hygienic measures: The usual precautionary measures for handling chemicals should be followed. Breathing equipment: Not required. Protection of hands: Not required. Material of gloves The selection of the suitable gloves does not only depend on the material, but also on further marks of quality and varies from manufacturer to manufacturer. As the product is a preparation of several substances, the resistance of the glove material can not be calculated in advance and has therefore to be checked prior to the application. Eye protection: Not required.
* 9 Physical and chemical properties
Information on basic physical and chemical properties
General Information
Appearance:
Form:
Fluid
Color:
Colorless
Odor:
Not determined
Odor threshold:
Not determined.
Change in condition Melting point/Melting range: Boiling point/Boiling range:
Flash point:
0 °C (32 °F) 100 °C (212 °F) Not applicable.
Flammability (solid, gaseous): Decomposition temperature:
Not applicable. Not determined.
(Contd. on page 4)
US
51.1.1
Printing date 09/16/2020 Trade name: Kinase Substrate
Safety Data Sheet
acc. to OSHA HCS
Page 4/7 Reviewed on 07/26/2020
Auto igniting:
Product is not selfigniting.
Danger of explosion: Explosion limits:
Lower: Upper: Vapor pressure:
Product does not present an explosion hazard.
Not determined. Not determined. Not determined.
Density at 20 °C (68 °F):
1 g/cm³ (8.345 lbs/gal)
Relative density
Not determined.
Vapor density
Not determined.
Evaporation rate
Not determined.
Solubility in / Miscibility with
Water:
Fully miscible.
Partition coefficient (n-octanol/water): Not determined.
Viscosity:
Dynamic:
Not determined.
Kinematic:
Not determined.
Water:
99.9 %
VOC content:
0.00 %
Solids content: Other information
0.1 % No further relevant information available.
(Contd. of page 3)
* 10 Stability and reactivity
Reactivity No further relevant information available. Chemical stability Thermal decomposition / conditions to be avoided: No decomposition if used according to specifications. Possibility of hazardous reactions No dangerous reactions known. Conditions to avoid No further relevant information available. Incompatible materials: No further relevant information available. Hazardous decomposition products: No dangerous decomposition products known.
* 11 Toxicological information
Information on toxicological effects
Acute toxicity: LD/LC50 values that are relevant for classification: No data available
Primary irritant effect: on the skin: No irritant effect. on the eye: No irritating effect. Sensitization: No sensitizing effects known.
Additional toxicological information: The product is not subject to classification according to internally approved calculation methods for
preparations:
Carcinogenic categories IARC (International Agency for Research on Cancer) None of the ingredients are listed.
(Contd. on page 5)
US
51.1.1
Printing date 09/16/2020 Trade name: Kinase Substrate
Safety Data Sheet
acc. to OSHA HCS
NTP (National Toxicology Program) None of the ingredients are listed.
OSHA-Ca (Occupational Safety & Health Administration) None of the ingredients are listed.
Page 5/7 Reviewed on 07/26/2020
(Contd. of page 4)
* 12 Ecological information
Toxicity Aquatic toxicity: Not available No further relevant information available. Persistence and degradability Not available No further relevant information available. Bioaccumulative potential Not known No further relevant information available. Mobility in soil No further relevant information available. Ecotoxicological effects: Remark: Not available Additional ecological information: General notes: Not available. Not known to be hazardous to water. Results of PBT and vPvB assessment PBT: Not applicable. vPvB: Not applicable. Other adverse effects No further relevant information available.
* 13 Disposal considerations
Waste treatment methods Recommendation: Disposal should be in accordance with applicable regional, national and local laws and regulations. Refer to Section 7: Handling and Storage and Section 8: Exposure Control/Personal Protection for additional handling information and protection of employees.
Uncleaned packagings: Recommendation: Disposal must be made according to official regulations. Recommended cleansing agent: Water, if necessary with cleansing agents.
* 14 Transport information
UN-Number DOT, ADR, ADN, IMDG, IATA
UN proper shipping name DOT, ADR, ADN, IMDG, IATA
Transport hazard class(es)
Not hazardous for transportation Not applicable
None Not applicable
None
(Contd. on page 6)
US
51.1.1
Printing date 09/16/2020 Trade name: Kinase Substrate
Safety Data Sheet
acc. to OSHA HCS
DOT, ADR, ADN, IMDG, IATA Class
Not applicable
Packing group DOT, ADR, IMDG, IATA
None Not applicable
Environmental hazards:
Marine pollutant:
No
Special precautions for user
Not applicable.
Transport in bulk according to Annex II of
MARPOL73/78 and the IBC Code
Not applicable.
UN "Model Regulation":
Not applicable
Page 6/7 Reviewed on 07/26/2020
(Contd. of page 5)
* 15 Regulatory information
Safety, health and environmental regulations/legislation specific for the substance or mixture Sara Section 355 (extremely hazardous substances): None of the ingredients are listed.
Section 313 (Specific toxic chemical listings): None of the ingredients are listed.
Hazardous Air Pollutants None of the ingredients are listed. Proposition 65 Chemicals known to cause cancer: None of the ingredients are listed.
Chemicals known to cause reproductive toxicity for females: None of the ingredients are listed.
Chemicals known to cause reproductive toxicity for males: None of the ingredients are listed.
Chemicals known to cause developmental toxicity: None of the ingredients are listed.
Cancerogenity categories EPA (Environmental Protection Agency) None of the ingredients are listed.
TLV (Threshold Limit Value established by ACGIH) None of the ingredients are listed.
NIOSH-Ca (National Institute for Occupational Safety and Health) None of the ingredients are listed. GHS label elements Not applicable Signal word Not applicable Hazard statements Not applicable
National regulations: No information available
Water hazard class: Generally not hazardous for water.
(Contd. on page 7)
US
51.1.1
Printing date 09/16/2020 Trade name: Kinase Substrate
Safety Data Sheet
acc. to OSHA HCS
Page 7/7 Reviewed on 07/26/2020
Chemical safety assessment: A Chemical Safety Assessment has not been carried out.
(Contd. of page 6)
16 Other information
This information is based on our present knowledge. However, this shall not constitute a guarantee for any specific product features and shall not establish a legally valid contractual relationship.
Department issuing SDS: Promega Corporation Chemical Regulatory Department 2800 Woods Hollow Road Madison, WI Ph:(608)274-4330 Date of preparation / last revision 09/16/2020 / 1.0 Abbreviations and acronyms:
RID: Règlement international concernant le transport des marchandises dangereuses par chemin de fer (Regulations Concerning the International Transport of Dangerous Goods by Rail) ICAO: Internation Civil Aviation Organization ADR: Accord européen sur le transport des marchandises dangereuses par Route (European Agreement concerning the International Carriage of Dangerous Goods by Road) IMDG: International Maritime Code for Dangerous Goods DOT: US Department of Transportation IATA: International Air Transport Association ACGIH: American Conference of Governmental Industrial Hygienists EINECS: European Inventory of Existing Commercial Chemical Substances ELINCS: European List of Notified Chemical Substances CAS: Chemical Abstracts Service (division of the American Chemical Society) NFPA: National Fire Protection Association (USA) HMIS: Hazardous Materials Identification System (USA) VOC: Volatile Organic Compounds (USA, EU) LC50: Lethal concentration, 50 percent LD50: Lethal dose, 50 percent PBT: Persistent, Bioaccumulative and Toxic vPvB: very Persistent and very Bioaccumulative NIOSH: National Institute for Occupational Safety OSHA: Occupational Safety & Health TLV: Threshold Limit Value PEL: Permissible Exposure Limit REL: Recommended Exposure Limit
* Data compared to the previous version altered.
US
51.1.1
Printing date 09/16/2020
Safety Data Sheet
acc. to OSHA HCS
Page 1/7 Reviewed on 09/14/2020
* 1 Identification
Product identifier Trade name: 5x Reaction Buffer A
Article number: Turnkey4 Application of the substance / the mixture For Laboratory Use
Details of the supplier of the safety data sheet Manufacturer/Supplier:
Promega Corporation 2800 Woods Hollow Road Madison, WI 53711 U.S.A. 1-800-356-9526 or (608)-274-4330
Information department: SDS author: ChemicalRegulatory@promega.com Promega Corporation 2800 Woods Hollow Road Madison, WI 53711 U.S.A. 1-800-356-9526 or (608)-274-4330 Emergency telephone number: For Chemical Emergency Spill, Leak, Fire, Exposure, or Accident Call CHEMTREC Day or Night Within USA and Canada: 1-800-424-9300 Outside USA and Canada: +1 703-527-3887 (collect calls accepted)
* 2 Hazard(s) identification
Classification of the substance or mixture The product is not classified as hazardous according to the Globally Harmonized System (GHS).
Label elements GHS label elements Not applicable Hazard pictograms Not applicable Signal word Not applicable Hazard statements Not applicable Classification system: NFPA ratings (scale 0 - 4) Health = 0 Fire = 0 Reactivity = 0 HMIS-ratings (scale 0 - 4) Health = 0 Fire = 0 Reactivity = 0 OSHA Hazard Overview (Criteria according to 29CFR1910.1200): Not applicable Target Organ(s): Not applicable or unknown
(Contd. on page 2)
US
51.1.1
Printing date 09/16/2020 Trade name: 5x Reaction Buffer A
Safety Data Sheet
acc. to OSHA HCS
Other hazards
Results of PBT and vPvB assessment PBT: Not applicable. vPvB: Not applicable.
Page 2/7 Reviewed on 09/14/2020
(Contd. of page 1)
* 3 Composition/information on ingredients
Chemical characterization: Mixtures Description: The product is made up of a mixture of non-hazardous components. The exact concentration percentages and
components name may be withheld as a Promega Corp. trade secret.
Dangerous components:
1185-53-1 Tris HCl
1-5%
Additional information: For the wording of the listed risk phrases refer to section 15.
* 4 First-aid measures
Description of first aid measures General information: No special measures required. After inhalation: If the patient feels unwell or is concerned, obtain medical advice. After skin contact: Generally the product does not irritate the skin. After eye contact: Rinse opened eye for several minutes under running water. After swallowing: If the patient feels unwell or is concerned, obtain medical advice. Information for doctor: Most important symptoms and effects, both acute and delayed None No further relevant information available. Indication of any immediate medical attention and special treatment needed No further relevant information available.
* 5 Fire-fighting measures
Extinguishing media Suitable extinguishing agents: CO2, extinguishing powder or water spray. Fight larger fires with water spray or alcohol resistant foam. Special hazards arising from the substance or mixture None known No further relevant information available. Advice for firefighters No special advice Protective equipment: No special measures required.
* 6 Accidental release measures
Personal precautions, protective equipment and emergency procedures Not required. Environmental precautions: Dilute with plenty of water. Do not allow to enter sewers/ surface or ground water.
Methods and material for containment and cleaning up: Absorb with liquid-binding material (sand, diatomite, acid binders, universal binders, sawdust).
(Contd. on page 3)
US
51.1.1
Printing date 09/16/2020 Trade name: 5x Reaction Buffer A
Safety Data Sheet
acc. to OSHA HCS
Reference to other sections No dangerous substances are released.
See Section 7 for information on safe handling.
See Section 13 for disposal information.
Page 3/7 Reviewed on 09/14/2020
(Contd. of page 2)
* 7 Handling and storage
Handling: Precautions for safe handling No special measures required. Information about protection against explosions and fires: The product is not flammable.
Conditions for safe storage, including any incompatibilities Storage: Requirements to be met by storerooms and receptacles: No special requirements. Information about storage in one common storage facility: Not required. Further information about storage conditions: None. Specific end use(s) No further relevant information available.
* 8 Exposure controls/personal protection
Control parameters Components with limit values that require monitoring at the workplace: The product does not contain any relevant quantities of materials with critical values that have to be monitored at the workplace. Additional information: The lists that were valid during the creation were used as basis.
Exposure controls Personal protective equipment: General protective and hygienic measures: The usual precautionary measures for handling chemicals should be followed. Breathing equipment: Not required. Protection of hands: Not required. Material of gloves The selection of the suitable gloves does not only depend on the material, but also on further marks of quality and varies from manufacturer to manufacturer. As the product is a preparation of several substances, the resistance of the glove material can not be calculated in advance and has therefore to be checked prior to the application. Eye protection: Not required.
* 9 Physical and chemical properties
Information on basic physical and chemical properties
General Information
Appearance:
Form:
Fluid
Color:
Colorless
Odor:
Not determined
Odor threshold:
Not determined.
Change in condition Melting point/Melting range: Boiling point/Boiling range:
0 °C (32 °F) 100 °C (212 °F)
(Contd. on page 4)
US
51.1.1
Printing date 09/16/2020 Trade name: 5x Reaction Buffer A
Safety Data Sheet
acc. to OSHA HCS
Page 4/7 Reviewed on 09/14/2020
Flash point:
Not applicable.
Flammability (solid, gaseous): Decomposition temperature:
Not applicable. Not determined.
Auto igniting:
Product is not selfigniting.
Danger of explosion: Explosion limits:
Lower: Upper: Vapor pressure:
Product does not present an explosion hazard.
Not determined. Not determined. Not determined.
Density at 20 °C (68 °F):
0.99739 g/cm³ (8.32322 lbs/gal)
Relative density
Not determined.
Vapor density
Not determined.
Evaporation rate
Not determined.
Solubility in / Miscibility with
Water:
Fully miscible.
Partition coefficient (n-octanol/water): Not determined.
Viscosity:
Dynamic:
Not determined.
Kinematic:
Not determined.
Water:
95.8 %
VOC content:
0.00 %
Solids content: Other information
5.2 % No further relevant information available.
(Contd. of page 3)
* 10 Stability and reactivity
Reactivity No further relevant information available. Chemical stability Thermal decomposition / conditions to be avoided: No decomposition if used according to specifications. Possibility of hazardous reactions No dangerous reactions known. Conditions to avoid No further relevant information available. Incompatible materials: No further relevant information available. Hazardous decomposition products: No dangerous decomposition products known.
* 11 Toxicological information
Information on toxicological effects
Acute toxicity: LD/LC50 values that are relevant for classification: No data available
Primary irritant effect: on the skin: No irritant effect.
on the eye: No irritating effect.
Sensitization: No sensitizing effects known.
Additional toxicological information: The product is not subject to classification according to internally approved calculation methods for
preparations:
(Contd. on page 5)
US
51.1.1
Printing date 09/16/2020 Trade name: 5x Reaction Buffer A
Safety Data Sheet
acc. to OSHA HCS
Carcinogenic categories IARC (International Agency for Research on Cancer) None of the ingredients are listed.
NTP (National Toxicology Program) None of the ingredients are listed.
OSHA-Ca (Occupational Safety & Health Administration) None of the ingredients are listed.
Page 5/7 Reviewed on 09/14/2020
(Contd. of page 4)
* 12 Ecological information
Toxicity Aquatic toxicity: Not available No further relevant information available. Persistence and degradability Not available No further relevant information available. Bioaccumulative potential Not known No further relevant information available. Mobility in soil No further relevant information available. Ecotoxicological effects: Remark: Not available Additional ecological information: General notes: Not known to be hazardous to water. Results of PBT and vPvB assessment PBT: Not applicable. vPvB: Not applicable. Other adverse effects No further relevant information available.
* 13 Disposal considerations
Waste treatment methods Recommendation: Disposal should be in accordance with applicable regional, national and local laws and regulations. Refer to Section 7: Handling and Storage and Section 8: Exposure Control/Personal Protection for additional handling information and protection of employees.
Uncleaned packagings: Recommendation: Disposal must be made according to official regulations. Recommended cleansing agent: Water, if necessary with cleansing agents.
* 14 Transport information
UN-Number DOT, ADR, ADN, IMDG, IATA
UN proper shipping name DOT, ADR, ADN, IMDG, IATA
Not hazardous for transportation Not applicable
None Not applicable
(Contd. on page 6)
US
51.1.1
Printing date 09/16/2020 Trade name: 5x Reaction Buffer A
Safety Data Sheet
acc. to OSHA HCS
Transport hazard class(es)
None
DOT, ADR, ADN, IMDG, IATA Class
Not applicable
Packing group DOT, ADR, IMDG, IATA
None Not applicable
Environmental hazards:
Marine pollutant:
No
Special precautions for user
Not applicable.
Transport in bulk according to Annex II of
MARPOL73/78 and the IBC Code
Not applicable.
UN "Model Regulation":
Not applicable
Page 6/7 Reviewed on 09/14/2020
(Contd. of page 5)
* 15 Regulatory information
Safety, health and environmental regulations/legislation specific for the substance or mixture Sara Section 355 (extremely hazardous substances): None of the ingredients are listed.
Section 313 (Specific toxic chemical listings): None of the ingredients are listed.
TSCA (Toxic Substances Control Act) Inventory: All ingredients are listed.
Hazardous Air Pollutants None of the ingredients are listed. Proposition 65 Chemicals known to cause cancer: None of the ingredients are listed.
Chemicals known to cause reproductive toxicity for females: None of the ingredients are listed.
Chemicals known to cause reproductive toxicity for males: None of the ingredients are listed.
Chemicals known to cause developmental toxicity: None of the ingredients are listed.
Cancerogenity categories EPA (Environmental Protection Agency) None of the ingredients are listed.
TLV (Threshold Limit Value established by ACGIH) None of the ingredients are listed.
NIOSH-Ca (National Institute for Occupational Safety and Health) None of the ingredients are listed. GHS label elements Not applicable Signal word Not applicable
(Contd. on page 7)
US
51.1.1
Printing date 09/16/2020 Trade name: 5x Reaction Buffer A
Safety Data Sheet
acc. to OSHA HCS
Page 7/7 Reviewed on 09/14/2020
Hazard statements Not applicable
Water hazard class: Water hazard class 1 (Self-assessment): slightly hazardous for water. Chemical safety assessment: A Chemical Safety Assessment has not been carried out.
(Contd. of page 6)
16 Other information
This information is based on our present knowledge. However, this shall not constitute a guarantee for any specific product features and shall not establish a legally valid contractual relationship.
Department issuing SDS: Promega Corporation Chemical Regulatory Department 2800 Woods Hollow Road Madison, WI Ph:(608)274-4330 Date of preparation / last revision 09/16/2020 / 1.0 Abbreviations and acronyms:
ADR: Accord européen sur le transport des marchandises dangereuses par Route (European Agreement concerning the International Carriage of Dangerous Goods by Road) IMDG: International Maritime Code for Dangerous Goods DOT: US Department of Transportation IATA: International Air Transport Association ACGIH: American Conference of Governmental Industrial Hygienists EINECS: European Inventory of Existing Commercial Chemical Substances ELINCS: European List of Notified Chemical Substances CAS: Chemical Abstracts Service (division of the American Chemical Society) NFPA: National Fire Protection Association (USA) HMIS: Hazardous Materials Identification System (USA) VOC: Volatile Organic Compounds (USA, EU) LC50: Lethal concentration, 50 percent LD50: Lethal dose, 50 percent PBT: Persistent, Bioaccumulative and Toxic vPvB: very Persistent and very Bioaccumulative NIOSH: National Institute for Occupational Safety OSHA: Occupational Safety & Health TLV: Threshold Limit Value PEL: Permissible Exposure Limit REL: Recommended Exposure Limit
* Data compared to the previous version altered.
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51.1.1
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acc. to OSHA HCS
Page 1/7 Reviewed on 09/14/2020
* 1 Identification
Product identifier Trade name: 0.1M DTT
Article number: Turnkey10 Application of the substance / the mixture For Laboratory Use
Details of the supplier of the safety data sheet Manufacturer/Supplier:
Promega Corporation 2800 Woods Hollow Road Madison, WI 53711 U.S.A. 1-800-356-9526 or (608)-274-4330
Information department: SDS author: ChemicalRegulatory@promega.com Promega Corporation 2800 Woods Hollow Road Madison, WI 53711 U.S.A. 1-800-356-9526 or (608)-274-4330 Emergency telephone number: For Chemical Emergency Spill, Leak, Fire, Exposure, or Accident Call CHEMTREC Day or Night Within USA and Canada: 1-800-424-9300 Outside USA and Canada: +1 703-527-3887 (collect calls accepted)
* 2 Hazard(s) identification
Classification of the substance or mixture The product is not classified as hazardous according to the Globally Harmonized System (GHS).
Label elements GHS label elements Not applicable Hazard pictograms Not applicable Signal word Not applicable Hazard statements Not applicable Classification system: NFPA ratings (scale 0 - 4) Health = 0 Fire = 0 Reactivity = 0 HMIS-ratings (scale 0 - 4) Health = 0 Fire = 0 Reactivity = 0 OSHA Hazard Overview (Criteria according to 29CFR1910.1200): Not applicable Target Organ(s): Not applicable or unknown
(Contd. on page 2)
US
51.1.1
Printing date 09/16/2020 Trade name: 0.1M DTT
Safety Data Sheet
acc. to OSHA HCS
Other hazards
Results of PBT and vPvB assessment PBT: Not applicable. vPvB: Not applicable.
Page 2/7 Reviewed on 09/14/2020
(Contd. of page 1)
* 3 Composition/information on ingredients
Chemical characterization: Mixtures Description: The product is made up of a mixture of non-hazardous components. The exact concentration percentages and
components name may be withheld as a Promega Corp. trade secret.
Dangerous components:
3483-12-3 DL-Dithiothreitol
1-5%
Additional information: For the wording of the listed risk phrases refer to section 15.
* 4 First-aid measures
Description of first aid measures General information: No special measures required. After inhalation: If the patient feels unwell or is concerned, obtain medical advice. After skin contact: Generally the product does not irritate the skin. After eye contact: Rinse opened eye for several minutes under running water. After swallowing: If the patient feels unwell or is concerned, obtain medical advice. Information for doctor: Most important symptoms and effects, both acute and delayed None No further relevant information available. Indication of any immediate medical attention and special treatment needed No further relevant information available.
* 5 Fire-fighting measures
Extinguishing media Suitable extinguishing agents: CO2, extinguishing powder or water spray. Fight larger fires with water spray or alcohol resistant foam. Special hazards arising from the substance or mixture None known No further relevant information available. Advice for firefighters No special advice Protective equipment: No special measures required.
* 6 Accidental release measures
Personal precautions, protective equipment and emergency procedures Not required. Environmental precautions: Dilute with plenty of water. Do not allow to enter sewers/ surface or ground water.
Methods and material for containment and cleaning up: Absorb with liquid-binding material (sand, diatomite, acid binders, universal binders, sawdust).
(Contd. on page 3)
US
51.1.1
Printing date 09/16/2020 Trade name: 0.1M DTT
Safety Data Sheet
acc. to OSHA HCS
Reference to other sections No dangerous substances are released.
See Section 7 for information on safe handling.
See Section 13 for disposal information.
Page 3/7 Reviewed on 09/14/2020
(Contd. of page 2)
* 7 Handling and storage
Handling: Precautions for safe handling No special measures required. Information about protection against explosions and fires: The product is not flammable.
Conditions for safe storage, including any incompatibilities Storage: Requirements to be met by storerooms and receptacles: No special requirements. Information about storage in one common storage facility: Not required. Further information about storage conditions: None. Specific end use(s) No further relevant information available.
* 8 Exposure controls/personal protection
Control parameters Components with limit values that require monitoring at the workplace: The product does not contain any relevant quantities of materials with critical values that have to be monitored at the workplace. Additional information: The lists that were valid during the creation were used as basis.
Exposure controls Personal protective equipment: General protective and hygienic measures: The usual precautionary measures for handling chemicals should be followed. Breathing equipment: Not required. Protection of hands: Not required. Material of gloves The selection of the suitable gloves does not only depend on the material, but also on further marks of quality and varies from manufacturer to manufacturer. As the product is a preparation of several substances, the resistance of the glove material can not be calculated in advance and has therefore to be checked prior to the application. Eye protection: Not required.
* 9 Physical and chemical properties
Information on basic physical and chemical properties
General Information
Appearance:
Form:
Fluid
Color:
Colorless
Odor:
Not determined
Odor threshold:
Not determined.
Change in condition Melting point/Melting range: Boiling point/Boiling range:
0 °C (32 °F) 100 °C (212 °F)
(Contd. on page 4)
US
51.1.1
Printing date 09/16/2020 Trade name: 0.1M DTT
Safety Data Sheet
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Page 4/7 Reviewed on 09/14/2020
Flash point:
Not applicable.
Flammability (solid, gaseous): Decomposition temperature:
Not applicable. Not determined.
Auto igniting:
Product is not selfigniting.
Danger of explosion: Explosion limits:
Lower: Upper: Vapor pressure:
Product does not present an explosion hazard.
Not determined. Not determined. Not determined.
Density at 20 °C (68 °F):
1 g/cm³ (8.345 lbs/gal)
Relative density
Not determined.
Vapor density
Not determined.
Evaporation rate
Not determined.
Solubility in / Miscibility with
Water:
Fully miscible.
Partition coefficient (n-octanol/water): Not determined.
Viscosity:
Dynamic:
Not determined.
Kinematic:
Not determined.
Water:
98.5 %
VOC content:
0.00 %
Solids content: Other information
1.5 % No further relevant information available.
(Contd. of page 3)
* 10 Stability and reactivity
Reactivity No further relevant information available. Chemical stability Thermal decomposition / conditions to be avoided: No decomposition if used according to specifications. Possibility of hazardous reactions No dangerous reactions known. Conditions to avoid No further relevant information available. Incompatible materials: No further relevant information available. Hazardous decomposition products: No dangerous decomposition products known.
* 11 Toxicological information
Information on toxicological effects
Acute toxicity: LD/LC50 values that are relevant for classification: No data available
Primary irritant effect: on the skin: No irritant effect.
on the eye: No irritating effect.
Sensitization: No sensitizing effects known.
Additional toxicological information: The product is not subject to classification according to internally approved calculation methods for
preparations:
(Contd. on page 5)
US
51.1.1
Printing date 09/16/2020 Trade name: 0.1M DTT
Safety Data Sheet
acc. to OSHA HCS
Carcinogenic categories IARC (International Agency for Research on Cancer) None of the ingredients are listed.
NTP (National Toxicology Program) None of the ingredients are listed.
OSHA-Ca (Occupational Safety & Health Administration) None of the ingredients are listed.
Page 5/7 Reviewed on 09/14/2020
(Contd. of page 4)
* 12 Ecological information
Toxicity Aquatic toxicity: Not available No further relevant information available. Persistence and degradability Not available No further relevant information available. Bioaccumulative potential Not known No further relevant information available. Mobility in soil No further relevant information available. Ecotoxicological effects: Remark: Not available Additional ecological information: General notes: Not known to be hazardous to water. Results of PBT and vPvB assessment PBT: Not applicable. vPvB: Not applicable. Other adverse effects No further relevant information available.
* 13 Disposal considerations
Waste treatment methods Recommendation: Disposal should be in accordance with applicable regional, national and local laws and regulations. Refer to Section 7: Handling and Storage and Section 8: Exposure Control/Personal Protection for additional handling information and protection of employees.
Uncleaned packagings: Recommendation: Disposal must be made according to official regulations. Recommended cleansing agent: Water, if necessary with cleansing agents.
* 14 Transport information
UN-Number DOT, ADR, ADN, IMDG, IATA
UN proper shipping name DOT, ADR, ADN, IMDG, IATA
Not hazardous for transportation Not applicable
None Not applicable
(Contd. on page 6)
US
51.1.1
Printing date 09/16/2020 Trade name: 0.1M DTT
Safety Data Sheet
acc. to OSHA HCS
Transport hazard class(es)
None
DOT, ADR, ADN, IMDG, IATA Class
Not applicable
Packing group DOT, ADR, IMDG, IATA
None Not applicable
Environmental hazards:
Marine pollutant:
No
Special precautions for user
Not applicable.
Transport in bulk according to Annex II of
MARPOL73/78 and the IBC Code
Not applicable.
UN "Model Regulation":
Not applicable
Page 6/7 Reviewed on 09/14/2020
(Contd. of page 5)
* 15 Regulatory information
Safety, health and environmental regulations/legislation specific for the substance or mixture Sara Section 355 (extremely hazardous substances): None of the ingredients are listed.
Section 313 (Specific toxic chemical listings): None of the ingredients are listed.
TSCA (Toxic Substances Control Act) Inventory: All ingredients are listed.
Hazardous Air Pollutants None of the ingredients are listed. Proposition 65 Chemicals known to cause cancer: None of the ingredients are listed.
Chemicals known to cause reproductive toxicity for females: None of the ingredients are listed.
Chemicals known to cause reproductive toxicity for males: None of the ingredients are listed.
Chemicals known to cause developmental toxicity: None of the ingredients are listed.
Cancerogenity categories EPA (Environmental Protection Agency) None of the ingredients are listed.
TLV (Threshold Limit Value established by ACGIH) None of the ingredients are listed.
NIOSH-Ca (National Institute for Occupational Safety and Health) None of the ingredients are listed. GHS label elements Not applicable Signal word Not applicable
(Contd. on page 7)
US
51.1.1
Printing date 09/16/2020 Trade name: 0.1M DTT
Safety Data Sheet
acc. to OSHA HCS
Page 7/7 Reviewed on 09/14/2020
Hazard statements Not applicable
Water hazard class: Water hazard class 1 (Self-assessment): slightly hazardous for water. Chemical safety assessment: A Chemical Safety Assessment has not been carried out.
(Contd. of page 6)
16 Other information
This information is based on our present knowledge. However, this shall not constitute a guarantee for any specific product features and shall not establish a legally valid contractual relationship.
Department issuing SDS: Promega Corporation Chemical Regulatory Department 2800 Woods Hollow Road Madison, WI Ph:(608)274-4330 Date of preparation / last revision 09/16/2020 / 1.0 Abbreviations and acronyms:
RID: Règlement international concernant le transport des marchandises dangereuses par chemin de fer (Regulations Concerning the International Transport of Dangerous Goods by Rail) ICAO: Internation Civil Aviation Organization ADR: Accord européen sur le transport des marchandises dangereuses par Route (European Agreement concerning the International Carriage of Dangerous Goods by Road) IMDG: International Maritime Code for Dangerous Goods DOT: US Department of Transportation IATA: International Air Transport Association ACGIH: American Conference of Governmental Industrial Hygienists EINECS: European Inventory of Existing Commercial Chemical Substances ELINCS: European List of Notified Chemical Substances CAS: Chemical Abstracts Service (division of the American Chemical Society) NFPA: National Fire Protection Association (USA) HMIS: Hazardous Materials Identification System (USA) VOC: Volatile Organic Compounds (USA, EU) LC50: Lethal concentration, 50 percent LD50: Lethal dose, 50 percent PBT: Persistent, Bioaccumulative and Toxic vPvB: very Persistent and very Bioaccumulative NIOSH: National Institute for Occupational Safety OSHA: Occupational Safety & Health TLV: Threshold Limit Value PEL: Permissible Exposure Limit REL: Recommended Exposure Limit
* Data compared to the previous version altered.
US
51.1.1
Acrobat Distiller 20.0 (Windows)