1475 11
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Non-Confidential 
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            1
#: 1475-11
Date: September 22, 2011 
To: All Participants 
Category: Dividends
From: International Services 
Attention:  Operations, Reorg & Dividend Managers, Partners & Cashiers 
Subject: Tax Relief – Country: Japan 
Eisai Co., Ltd. CUSIP: 282579309 
Record Date: 09/29/11  Payable Date: TBA 
EDS Cut-Off: 10/06/11  Documentation Cut-Off: 10/06/11 8PM 
Participants can use DTC’s Elective Dividend System (EDS) function over the Participant Terminal 
System (PTS) or TaxRelief option on the Participant Browser System (PBS) web site to certify all or a 
portion of their position entitled to the applicable withholding tax rate.
Questions regarding this Important Notice may be directed to Globe Tax. 212-747-9100 
Important Legal Information:  The Depository Trust Company (“DTC”) does not represent or warrant the accuracy, adequacy, 
timeliness, completeness or fitness for any particular purpose of the information contained in this communication, which is based in part 
on information obtained from third parties and not independently verified by DTC and which is provided as is.  The information contained 
in this communication is not intended to be a substitute for obtaining tax advice from an appropriate professional advisor.  In providing 
this communication, DTC shall not be liable for (1) any loss resulting directly or indirectly from mistakes, errors, omissions, interruptions, 
delays or defects in such communication, unless caused directly by gross negligence or willful misconduct on the part of DTC, and (2) any 
special, consequential, exemplary, incidental or punitive damages. 
To ensure compliance with Internal Revenue Service Circular 230, you are hereby notified that: (a) any discussion of federal tax issues 
contained or referred to herein is not intended or written to be used, and cannot be used, for the purpose of avoiding penalties that may be 
imposed under the Internal Revenue Code; and (b) as a matter of policy, DTC does not provide tax, legal or accounting advice and
accordingly, you should consult your own tax, legal and accounting advisor before engaging in any transaction.

EISAI CO., LTD. has announced a cash 
dividend. JPMorgan Chase Bank acts as 
the Depositary for the company’s 
American Depositary Receipt (“ADR”) 
program.  
Participants can use DTC’s Elective 
Dividend System (EDS) function over the 
Participant Terminal System (PTS) or 
Tax Relief option on the Participant 
Browser System (PBS) web site to certify 
all or a portion of their position entitled to 
the applicable withholding tax rate. Use 
of EDS will permit entitlement amounts to 
be paid through DTC. 
On ADR Pay Date, all non-Japanese 
resident holders will receive this dividend 
net of Japanese withholding tax of 7% 
with the possibility to reclaim as outlined 
in the Eligibility Matrix below. 
ELIGIBILITY MATRIX
RATE DESCRIPTION  RECLAIM 
RATE  ELIGIBLE RESIDENTS  DOCUMENTATION REQUIRED 
10% 0%  JAPANESE INDIVIDUAL 
RESIDENTS  1. APPENDIX A 
FAVORABLE - 7%  0%  ALL BENEFICIARIES EXCEPT 
JAPANESE INDIVIDUAL 
RESIDENTS AND TREATY 
ELIGIBLE PENSIONS
NO DOCUMENTATION REQUIRED 
EXEMPT - 0%  7%  TREATY ELIGIBLE NON-
JAPANESE RESIDENT 
PENSIONS
(PLEASE SEE EXHIBIT 1) 
1. FORM 6166 
2. APPENDIX A 
3. POWER-OF-ATTORNEY (APPENDIX B)
20%  0%  LARGE SHAREHOLDERS 
THAT HOLD 3% OR MORE 
OF THE OUTSTANDING 
SHARES EXCLUDING 
FOREIGN/(JAPANESE) 
DOMESTIC CORPORATE 
LARGE SHAREHOLDERS 
FOR DIVIDEND INCOME 
2. APPENDIX A 
DIVIDEND EVENT DETAILS 
COUNTRY OF ISSUANCE  JAPAN 
ISSUE  EISAI CO., LTD. 
CUSIP#  282579309 
DEPOSITARY  J.P. Morgan Chase Bank
ADR RECORD DATE  September 29, 2011 
ADR PAY DATE  TBA 
ADR GROSS DIVIDEND RATE 
ON PAY DATE  TBA
ORD GROSS DIVIDEND RATE 
ON PAY DATE  TBA
RATIO  TBA
RATE OF TAX WITHHOLDING  7% (3% additional local 
tax for Japanese individual 
residents only) 

CHARGES & DEADLINES
FILING METHOD  BATCH  PAYMENT 
METHOD
DEPOSITARY 
SERVICE
CHARGE 
MINIMUM SERVICE 
CHARGE PER    
BENEFICIAL OWNER 
FINAL 
SUBMISSION
DEADLINE 
(ALL TIMES 
EST)
RELIEF AT 
SOURCE  PAYMENT ON PAY 
DATE  EDS UP TO $0.0035 
per ADR  $0  October 6, 
2011; 8:00 P.M.
LONG-FORM  POST-EDS PROCESS; 
ONGOING  CHECK  UP TO $0.005 
per ADR  UP TO $400 
UP TO 5 
YEARS FROM 
ADR RECORD 
DATE 
DESCRIPTION OF VARIOUS DOCUMENTATION   
DOCUMENT NAME  DESCRIPTION ORIGINAL / COPY  SIGNATURE 
REQUIREMENT
IRS FORM 6166  ISSUED BY THE INTERNAL REVENUE 
SERVICE, STATING THE NAME AND TAX 
PAYER IDENTIFICATION NUMBER OF THE 
BENEFICIAL OWNER. IT MUST BE DATED 
WITHIN 9 MONTHS OF SUBMISSION. CANNOT 
BE CERTIFIED FOR ANY OTHER COUNTRY. 
MUST HAVE IRS CODES 401(A) AND 501 (A) 
ORIGINAL IRS
REPRESENTATIVE 
APPENDIX 
A
(COVER LETTER) 
LISTING OF BENEFICIAL OWNERS AND/OR 
JAPANESE INDIVIDUAL RESIDENTS  ORIGINAL DTC PARTICIPANT 
APPENDIX B 
(POWER OF 
ATTORNEY) 
SIGNED BY BENEFICIAL OWNER APPOINTING 
DEPOSITARY ON BENEFICIAL OWNER’S 
LETTERHEAD 
ORIGINAL BENEFICIAL OWNER 
LIMITED POWER 
OF ATTORNEY  IF THE POA IS SIGNED BY THE BROKER, 
TRUST AGREEMENT OR LIMITED POA MUST 
ALSO BE SUBMITTED 
COPY DTC PARTICIPANT 
APPENDIX C  CERTIFICATE OF RESIDENCE FOR UK 
PENSIONS ORIGINAL UK TAX AUTHORITY 
 WITHHOLDING TAX UPDATE REGARDING “LARGE SHAREHOLDERS”
Individual (non-Corporate) "large shareholders" who hold 3% or more of the number of outstanding shares for 
dividend income from listed shares, now fall under the "large shareholder" category. These "large shareholders" will 
no longer be eligible for the preferential tax rates and thus be applied the 20% tax rate for dividends paid after 
September 30, 2011. Participants are required to disclose the name and address of these "large shareholders" to the 
Depositary by the deadline stated within this notice. Corporate entities (both Japanese and non-Japanese) who hold 
3% or more of the number of outstanding shares for dividend income from listed shares are still entitled to the 
preferential withholding rates and are eligible to receive the income with a 7% withholding rate applied or more if 
eligible based on the treaty between the investors country of residence and Japan. Dividend income for unlisted 
shares will continue to be withheld at the 20% Japanese National Tax Rate. 

FREQUENTLY ASKED QUESTIONS (FAQs) 
QUESTION  ANSWER
CAN I SUBMIT A TRUST AGREEMENT IN LIEU OF A 
POA SIGNED BY THE BENEFICIAL OWNER? 
YES, BUT A LIMITED POA SIGNED BY THE 
PARTICIPANT  MUST BE ACCOMPANIED BY THE 
TRUST AGREEMENT 
ARE FORM 6166S WITH IRS CODE RULING 81-100 
ACCEPTED?  YES, WITH A TAX DETERMINATION LETTER 
DOES THE BENEFICIARIES NAME ON THE FORM 
6166 NEED TO MATCH THE POA?  YES, THE BENEFICIARIES NAME ON BOTH 
DOCUMENTS SHOULD BE IDENTICAL. 
HOW LONG DOES IT TAKE FOR LONG-FORM 
CLAIMS TO BE PAID?  WE ESTIMATE IT TAKES UP TO 1 YEAR FOR LONG 
FORM CLAIMS TO BE PAID 
DOES THE LONG-FORM PROCESS HAVE A 
MINIMUM POSITION REQUIRMENT PER 
BENEFICIAL OWNER?   YES, PLEASE CALL FOR MORE DETAILS. 
DO POAS NEED TO BE NOTARIZED FOR SHORT 
FORM CLAIMS?  NO, ONLY POAS SUBMITTED FOR LONG FORM 
CLAIMS NEED TO BE NOTARIZED. 
WHAT IS THE STATUTE OF LIMITATIONS FOR 
FILING JAPANESE RECLAIMS? 
 IT IS 5 YEARS FROM ORDINARY PAY DATE. CLAIMS 
RECEIVED AFTER OUR SUBMISSION DEADLINE 
WILL BE FILED ON A BEST EFFORT BASIS. 
WHAT IF THE BENEFICIAL OWER NAME AND/OR 
ADDRESS IS NOT CONSISTANT WITH THE OTHER 
DOCUMENTS? 
SEND A LETTER ON PARTICIPANT LETTERHEAD 
EXPLAINING THE DISCREPANCY.  BE SURE TO 
INCLUDE THE TAX ID NUMBER. 
J.P. Morgan Chase Bank, now offers ESP powered by GlobeTax, an electronic withholding tax 
submission system. This system allows for the secure and simplified transfer of beneficial owner 
level data from the Participant to J.P. Morgan Chase Bank and creates applicable documentation 
on the Participants behalf.
Submit the data online through the web site below, print out the document on letterhead, sign, and 
mail to J.P. Morgan Chase Bank / GlobeTax along with the additional documentation (necessary 
for U.S. Pensions, U.K. Pensions, Japanese Residents and Large Shareholders).  
These claims should be submitted through the following web site. (Requires a one-time registration) 
https://www.globetaxesp.com
Please contact Jonathan Staake at 212-747-9100  if you have any questions about this process. 

CONTACT DETAILS 
PRIMARY CONTACT  RITA PATEL 
DOMESTIC PHONE (U.S.)  1-800-929-5484 
DOMESTIC FAX (U.S.)  1-800-929-9986 
INTERNATIONAL PHONE  1-212-747-9100 
INTERNATIONAL FAX  1-212-747-0029 
EMAIL ADDRESS  RITA_PATEL@GLOBETAX.COM 
COMPANY  JPMORGAN CHASE BANK/ GLOBETAX 
STREET ADDRESS  90 BROAD STREET, 16
TH
 FLOOR 
CITY/STATE/ZIP  NEW YORK, NY 10004 
ADDITIONAL CONTACTS  SARAH MARTIN 
JONATHAN STAAKE 

APPENDIX A – COVER LETTER
(DTC Participant’s Letterhead) 
To:  JPMorgan Chase Bank / GlobeTax 
  90 Broad Street, 16th Floor 
  New York, New York 10004-2205 
  Phone: 1-800-929-5484   Fax: 1-800-929-9986 
Re: Withholding Certification for  EISAI CO., LTD.   ;   CUSIP#  282579309
I / We the undersigned                (Contact Name)               authorized representative of                  (DTC Participant Name)______
holding shares at Cede & Co. under DTC#           (DTC PTS Number)       of     EISAI CO., LTD. ;  CUSIP#  282579309,    request that 
the upcoming cash dividend payable to holders as of        September 29, 2011          , receive their entitled tax reclaim. 
Name of Beneficiary  Complete Address  Country of 
Residence  Tax ID Number # ADRs  
Law of 
Establishment
(ERISA, State Law 
of <State>, etc.) 
*** IF THERE ARE MORE THAN 7 BENEFICIAL HOLDERS, PLEASE CALL THE NUMBER ABOVE AND WE WILL SEND YOU A PRE-
FORMATTED DISK. PLEASE RETURN THE DISK AND THE HARD COPY WITH THE REQUIRED AUTHORIZED SIGNATURES TO THE 
ADDRESS ABOVE. 
I / We certify that to the best of my knowledge the above beneficial owners are eligible for the preferential rates as stated herein and I declare that I have performed 
all the necessary due diligence to satisfy myself as to the accuracy of the information submitted to me by these beneficial owners. 
JPMorgan Chase Bank is not liable for failure to secure the refund and any funds erroneously received shall be immediately returned to JPMorgan Chase Bank, 
including any interest, additions to tax or penalties thereon.  This is not tax advice. Please consult your tax advisor. 
Incorrect claims and/or elections could result in fines and/or penalties.   
TEL :  _________________________________________        
      Print Name of Signatory 
FAX:  _________________________________________        
      Position of Signatory 
PLEASE INCLUDE YOUR PHONE AND FAX NUMBER SO THAT WE CAN CONTACT YOU  
WITH ANY QUESTIONS THAT WE MIGHT HAVE.

APPENDIX B – POWER OF ATTORNEY 
(Pension Fund’s Letterhead) 
Power of Attorney  
(Name of Pension Fund/IRA = the Undersigned), with address in (City, State, Country) hereby 
appoints JPMorgan Chase (“Bank”) and/or the Bank’s designated standing proxy(ies) as its true and 
lawful attorney with full Power of Attorney to do all or any of the following acts with respect to the 
American Depository Receipts representing shares in EISAI CO., LTD. (“Securities”) that the Bank 
holds in its safe custody on behalf of the Undersigned through a Participant in the Depository Trust 
Company . 
i)  To sign and file required forms with competent tax authorities in order to secure any tax 
privileges and benefits such as tax reduction or tax-exemption at source. 
ii)  To receive on behalf of the Undersigned tax repayments made by competent tax authorities 
as a result of lodging reclaim forms. 
iii)  To perform any other act as may be necessary to execute the acts mentioned herein. 
The Undersigned also authorizes the Bank and/or the Bank’s designated standing  
proxy(ies) to submit this power of attorney or a photocopy of it to competent tax  
authorities. 
                        (Name of the Pension Fund/IRA)
_             <Place and Date>__________      _    _<Signature of Officer of Beneficiary>____ 
                 Place and Date             Authorized Signature(s)/Title(s)  
In addition, the authorized representative: 
Confirms that more than 50% of the beneficiaries, members or participants of the eligible pension 
fund were individual residents of the ________ or Japan as of the prior taxable period. 
                         (Name of the Pension Fund/IRA)
_             <Place and Date>__________      _    _<Signature of Officer of Beneficiary>____ 
                 Place and Date          Authorized Signature(s)/Title(s)

APPENDIX C 
ᒃఫ⪅ド᫂᭩
Certificate of Residence 
⚾ࡣࠊᒆฟ⪅ ________________________________________________________
ࡀࠊ᪥ᮏᅜ_________________________________________________________
ࡢ㛫ࡢ ⛒⛯᮲⣙➨_____᮲➨___㡯____つᐃࡍࡿᒃఫ⪅࡛࠶ࡿࡇࢆド᫂ࡋࡲࡍࠋ
I hereby certify that (the applicant:)____________________________________ 
is a resident under the provisions of the Income Tax Convention between Japan and the 
United Kingdom of Great Britain and Northern Ireland, Article 22, para. 2 (e) .
ᖺ᭶᪥      ____________________________
Date   _______/_________/___________
⨫ྡ   ____________________________________ 
Signature     _____________________________________ 
ᐁ ༳
Official Stamp 
                         

EXHIBIT 1 
TREATY ELIGIBLE PENSIONS
COUNTRY OF 
PENSION FUND  DESCRIPTION QUALIFYING PLANS 
UNITED STATES 
APPLIES TO A BENEFICIAL OWNER OF THE 
ADRS THAT: 
 1) IS NOT ENGAGED IN A TRADE OR 
BUSINESS IN JAPAN THROUGH A PERMANENT 
ESTABLISHMENT SITUATED IN JAPAN, WITHIN 
THE MEANING OF THE U.S. DOUBLE TAXATION 
TREATY WITH JAPAN 
2) IS A QUALIFYING “PENSION FUND” AS 
DEFINED ON PAGE 11 OF THE TECHNICAL 
EXPLANATION OF THE NEW TAX TREATY 
BETWEEN THE U.S. AND JAPAN, PUBLISHED 
BY THE U.S. DEPARTMENT OF TREASURY 
3) IS ABLE TO CERTIFY THAT MORE THAN      
50 % OF THE BENEFICIARIES, MEMBERS OR 
PARTICIPANTS OF THE ELIGIBLE PENSION 
FUND WERE INDIVIDUAL RESIDENTS OF THE 
U.S. OR JAPAN AS OF THE PRIOR TAXABLE 
PERIOD.
- QUALIFIED PLANS UNDER SECTION 401(A)  
- INDIVIDUAL RETIREMENT PLANS (INCLUDING  
   THOSE THAT ARE A PART OF A SIMPLIFIED  
   EMPLOYEE PENSION PLAN THAT SATISFIES 408(K))
- INDIVIDUAL RETIREMENT ACCOUNTS, INDIVIDUAL  
   RETIREMENT ANNUITIES, SECTION 408(P)  
   ACCOUNTS 
- ROTH IRAS UNDER SECTION 408 A 
- SECTION 457 GOVERNMENTAL PLANS 
- SECTION 403(A) QUALIFIED ANNUITY PLANS 
- SECTION 403(B) PLANS 
- SECTION 401(K) PLANS QUALIFY AS PENSION   
   FUNDS BECAUSE A 401(K) PLAN IS A TYPE OF    
   401(A) PLAN. 
- ANY OTHER FUND IDENTICAL OR SUBSTANTIALLY  
   SIMILAR TO THE FOREGOING SCHEMES THAT ARE 
   ESTABLISHED PURSUANT TO LEGISLATION  
   INTRODUCED AFTER THE DATE OF SIGNATURE OF 
   THE CONVENTION.  
UNITED KINGDOM 
APPLIES TO A BENEFICIAL OWNER OF THE 
ADRS THAT: 
1) IS NOT ENGAGED IN A TRADE OR BUSINESS 
IN JAPAN THROUGH A PERMANENT 
ESTABLISHMENT SITUATED IN JAPAN, WITHIN 
THE MEANING OF THE U.K. DOUBLE TAXATION 
TREATY WITH JAPAN,  
2) IS A QUALIFYING “PENSION FUND” AS 
DEFINED BY ARTICLE 22, PARAGRAPH 2(E) OF 
THE INCOME TAX CONVENTION BETWEEN 
JAPAN AND THE UNITED KINGDOM OF GREAT 
BRITAIN AND NORTHERN IRELAND, 
PUBLISHED BY THE MINISTRY OF FINANCE 
JAPAN
3) IS ABLE TO CERTIFY THAT MORE THAN     
50 % OF THE BENEFICIARIES, MEMBERS OR 
PARTICIPANTS OF THE ELIGIBLE PENSION 
FUND WERE INDIVIDUAL RESIDENTS OF THE 
U.K. OR JAPAN AS OF THE PRIOR TAXABLE 
PERIOD.