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61ST ASMS Conference on Mass Spectrometry and Allied Topics
June 9 - 13, 2013 • Minneapolis, Minnesota

This year we celebrate 100 years of mass spectrometry. Each conference registrant will receive a free reproduction of
J.J. Thomson’s 1913 edition of Rays of Positive Electricity. Pick up your copy in the “Museum” located adjacent to Exhibit Hall C. In
the museum you will also find:
• Display of historical instruments and accessories
• History posters
• For sale: “Evolution of Mass Spectrometry: 1910-1940,” set of two wall posters (36” X 17.5”), $20 per set
Don’t miss these other commemorative features of the meeting.
• Sunday, 6:45 - 7:45 pm: Michael L. Gross, The First Fifty Years of MS: Building a Foundation
• Wednesday Poster Session: Historical Posters, WP 001 and 002
• Thursday, 2:30 - 4:30 pm: Celebration of 100th Anniversary of Mass Spectrometry, Room 103

Sponsors

ASMS gratefully acknowledges the support
of these companies.

Table

of

Contents

General Information....................................... 2
Hotels

and

Transportation............................ 5

ASMS Board

of

Interest Groups
Internet Cafés

Directors............................. 6
and

Committees. ................. 7

Awards.............................................................. 8
Convention Center Floor Plans................. 10
Poster / Exhibit Hall Floor Plan................11
Corporate Hospitality Suites...................... 12

Closing Gala

Conference Sponsors

ASMS Corporate Members.......................... 13
Program Acknowledgements........................ 17
Program Overview......................................... 18
Workshops...................................................... 23

Titles in the following sections are provided by authors. The
complete abstracts are available online: www.asms.org
The PDF document of proceedings submissions for orals and
posters are online one day after presentation at the conference.

Contributors
IDEX Health & Science
New Objective
SGE Analytical Science
Tandem Labs
Thermo Scientific
Zef Scientific

Sunday............................................................. 27
Monday Oral Sessions.................................. 27
Tuesday Oral Sessions................................. 33
Wednesday Oral Sessions. ........................... 40
Thursday Oral Sessions............................... 46
Monday Posters............................................. 53
Tuesday Posters............................................ 86
Wednesday Posters.......................................119
Thursday Posters........................................ 152
Index of Authors......................................... 183

61ST ASMS CONFERENCE ON MASS SPECTROMETRY						

PAGE 1

GENERAL INFORMATION

Registration is open 10:00 am - 8:00 pm on Sunday and
7:30 am - 5:00 pm on Monday through Thursday.
Sunday Tutorial Session, 5:00 - 6:30 pm
Exhibit Hall A, Lower Level

PLENARY SESSIONS
Monday, 4:45 - 5:30 pm
Exhibit Hall A, Lower Level
Award Lecture
Award for a Distinguished
Contribution in Mass Spectrometry

5:00 - 5:45 pm
A Wide Spectrum: Clinical
Diagnostics for the Masses

Richard D. Smith
Pacific Northwest National Laboratory

Andrew Hoofnagle
University of Washington

5:45 - 6:30 pm
The Nuts and Bolts of Protein
Hydrogen Exchange MS

Tuesday, 4:45 - 5:30 PM
Exhibit Hall A, Lower Level
Award Lecture
Biemann Medal

John Engen
Northeastern University

Yinsheng Wang
University of California, Riverside

6:45 - 7:45 PM, SUNDAY

Sunday Conference Opening, 6:45 - 7:45 pm
Exhibit Hall A, Lower Level CONFERENCE OPENING

6:45 - 7:45 PM, SUNDAY

Exhibit Hall A, Exhibit level

Welcome, Jenny Brodbelt
University of Texas, Austin
ASMS Vice President for Programs

Thursday, 4:45 - 5:30 PM
Exhibit Hall A, Lower Level CONFERENCE OPENING

Exhibit Hall A, Exhibit level

Plenary Lecture
Discovery of the Elusive Higgs Boson
Peter Onyisi
University of Texas at Austin
Then...

Now...

DON’T MISS
• ASMS MEETING, WEDNESDAY, 4:45 - 5:30 PM
Ballroom A
Enjoy a beverage while you applaud awards, hear the new
initiatives under construction, and more!
The First Fifty Years of MS: Building a Foundation
Michael L. Gross
Washington University of St. Louis

• CLOSING GALA, THURSDAY, 5:45 - 9:00 PM
Exhibit Hall D
Let’s celebrate! The event features a buffet, cash bar,
fun and games. Ticket is required, $30 for conference
registrant, $20 for student.

Sunday Welcome Reception, 7:45 - 9:00 pm
Exhibit Hall BC. Conference name badge is required.
Exhibit Hall BC, Exhibit level

PAGE 2					

61ST ASMS CONFERENCE ON MASS SPECTROMETRY

GENERAL INFORMATION

Oral Sessions are 8:30 - 10:30 am and 2:30 - 4:30 pm on
Monday through Thursday.
Session A (MOA, TOA, WOA, ThOA)..............Exhibit Hall A
(lower level)
Session B (MOB, TOB, WOB, ThOB)..... L100 (lower level)
Session C (MOC, TOC, WOC, ThOC)............... Ballroom B
Session D (MOD, TOD, WOD, ThOD)............... Ballroom A
Session E (MOE, TOE, WOE, ThOE)................ Auditorium
Session F (MOF, TOF, WOF, ThOF)...................Room 101
Session G (MOG, TOG, WOG, ThOG)...............Room 102
Session H (MOH, TOH, WOH, ThOH)................Room 103
Oral Presentations are projected from ASMS computers
running Microsoft Office 2010. Speakers are required to use the
ASMS computers for their presentations.
Speakers must load presentations at least one day prior to their
talks. The speaker room is M101C (down to mezzanine level)
and is open with a technician according to this schedule:
Sunday: 10:00 am - 8:00 pm
Monday through Wednesday: 7:30 am - 5:00 pm
Posters and Exhibit Booths are in Exhibit Hall BC. The Hall
is open:
Sunday Reception......................7:45 pm - 9:00 pm
Monday - Wednesday................7:30 am - 8:00 pm
Thursday....................................7:30 am - 3:30 pm
Poster Set-Up is 7:30 am on the day scheduled and removal
is 7:30 – 8:00 pm on the same day. Posters should not be
removed early. Thursday posters must be removed by 3:30 pm.
Refer to the poster numbers in this final program for board
assignments. Presenters should supply pushpins or Velcro to
mount their posters.
Poster Sessions are 10:30 am – 2:30 pm, Monday through
Thursday.
Poster Authors must be present at posters on scheduled
days at these times.
10:30 am - 1:00 pm............Odd-numbered posters
12:00 - 2:30 pm................ Even-numbered posters
Presenters who must leave a poster unattended should post a
return time. Presenters should wear “Poster Presenter” badges
which are available at the poster supply counter..
Lunch Concessions in and near the exhibit hall are open 11:00
am - 2:00 pm.
Exhibitors must staff booths as follows:
Sunday Reception......................7:45 pm - 9:30 pm
Monday - Thursday..................10:30 am - 2:30 pm

Workshops are 5:45 - 7:00 pm on Monday, Tuesday, and
Wednesday. Light refreshments are provided in the pre-function
area on level two.
Dinner Break, 7:00 - 8:00 pm is time for a breath of fresh air
before the opening of hospitality suites at 8:00 pm. Visit the “Meet
Minneapolis” booth for restaurant suggestions and reservations.
The booth also features useful information about Minneapolis
museums, shopping, attractions, nightlife and much more!
Free WiFi Access is provided in the Poster/Exhibit Hall.
Computers are provided at stations throughout the convention center.
Conference Proceedings will be published online. Visit www.
asms.org after July 15 to view or download the Proceedings.
Submission to the Proceedings does not constitute publication
and does not jeopardize the rights of authors to publish contents
of their submissions. Speaker web casting slides will be printed
to PDF and used for speakers who fail to submit.
Web Casting includes tutorial lectures, plenary lectures, and
oral sessions. Web casting will be available to conference
attendees for three months after the conference. ASMS does
not retain rights to material included in web castings. To access
the presentations, go to www.asms.org, select “web casting” on
the annual conference page, and enter your last name and the
User ID printed on your conference name badge.
Corporate Hospitality Suites may be open 8:00 pm, Monday
through Wednesday. Suites are located in the Hilton Hotel.
Corporate Breakfast Seminars are hosted by some Corporate
Members. Please reserve a seat at company exhibit booths.
For list of companies hosting a breakfast, refer to Corporate
Member listing in this program or www.asms.org.
Employment Center is located in the Poster/Exhibit Hall.
The room is open to all conference attendees. Applicants and
employers must enter resumes and employment opportunities
online. No hard copies of resumes or employment opportunities
will be posted in the center. There are computers in the center for
searching the database of candidates and positions. Interview
booths must be reserved one day in advance.
Sunday.............................................1:00 - 8:00 pm
Monday – Wednesday...............7:30 am - 5:00 pm
Thursday....................................7:30 am - 2:30 pm
Guest Registration ($10) includes designated name badge
and entrance to the Sunday evening reception.

61ST ASMS CONFERENCE ON MASS SPECTROMETRY						

PAGE 3

GENERAL
GENERALINFORMATION
INFORMATION

Media Events

Corporate media sessions are scheduled on Monday and
Tuesday for members of the press and financial institutions.
Company

Monday

Conference Regulations
• Name badges are required for all conference sessions,
including the exhibit hall and the employment center.

Hilton Hotel Location

• No smoking is permitted in the convention center.

Shimadzu

8:00-9:00 am

Marquette I-III, VII-IX

• Cell phones must be turned off in oral sessions.

Bruker Daltonics

9:30-10:30 am

Conrad

AB SCIEX

11:00-12:00 pm

Symphony Ballroom

• No photography or recording is allowed in oral sessions or
in the Poster-Exhibit Hall.

Agilent Technologies

1:30-2:30 pm

Grand Ballroom ABC

Thermo Scientific

3:00-4:00 pm

Grand Ballroom EFG

Waters Corporation

4:30-5:30 pm

Grand Ballroom D

Company
PerkinElmer

Tuesday
9:30-10:30 am

Location
Marquette IV-VII

• Material presented or displayed at the ASMS Conference,
including but not limited to orals, posters, workshops,
exhibit booths and hospitality suites, is the intellectual
property of the presenter and may not be recorded,
photographed, quoted, disseminated or transmitted by
summary in any form without the express written authority
of ASMS and the author of the material presented. Such
materials, only upon approval by ASMS and the author,
may be published in print or online, and must contain
appropriate credits for all quotations or photographs.
• The placement of advertising in the meeting area is strictly
limited. There are poster boards and tables in the Exhibit
Hall for corporate member notices and literature. No signs
on easels are permitted. Other approved notices and
announcements may be posted on designated Boards in
the Exhibit Hall.
• Hardware, accessories or any items for sale may be
displayed only in corporate exhibit booths and hospitality
suites.
• No organized activities (even off-site) other than those
approved by ASMS are allowed during the conference week
(5:00 pm on Sunday through 6:00 pm on Thursday).
• Corporate or institutional logos in slides or posters may
appear only one time in the presentation.

PAGE 4					

61ST ASMS CONFERENCE ON MASS SPECTROMETRY

HOTELS AND TRANSPORTATION

Conference Hotels

Transportation

1

Best Western

612-370-1400

2

Crowne Plaza

612-338-2288

3

Doubletree Suites

612-332-6800

4

Graves 601 Wyndham Grand

612-677-1100

Travel free through the heart of downtown Minneapolis. Look
for “Free Ride” buses on Nicollet Mall between the Convention
Center and Washington Avenue, including a connection with
the Hiawatha light-rail line, with service to the airport and Mall
of America. Free bus service is available approximately every
10 minutes from 7 am to 7 pm on weekdays and roughly every
15-30 minutes on evenings and weekends.

5

Hilton Minneapolis

612-376-1000

6

Hilton Garden Inn

612-339-6633

There is also an extensive skywalk system in Minneapolis.

7

Holiday Inn Express

612-341-3300

8

Hotel Ivy

612-746-4600

9

Hotel Minneapolis

612-340-2000

10

Hyatt Regency

612-370-1234

Map
No.

Hotel

Telephone

11

Marquette

612-333-4545

12

Marriott City Center

612-349-4000

13

Millenium

612-332-6000

14

Radisson Plaza

612-339-4900

15

Residence Inn

612-677-1000

16

W Minneapolis

612-215-3700

17

Westin Minneapolis

612-333-4006

Image below shows bus stops.

61ST ASMS CONFERENCE ON MASS SPECTROMETRY						

PAGE 5

GENERAL
INFORMATION
ASMS
BOARD
OF DIRECTORS

President
Susan T. Weintraub
University of Texas Health Science Center
San Antonio, TX

Congratulations
to these members who were elected to the ASMS Board
Vice President for Arrangements

Past President
Scott A. McLuckey
Purdue University
West Lafayette, IN

Vice President for Programs
Jenny Brodbelt
University of Texas
Austin, TX

Gary Valaskovic
New Objective, Inc.
Secretary

Vice President for Arrangements
Lance Nicolaysen
Waters Corporation
Beverly, MA

Treasurer

Neil L. Kelleher
Northwestern University
Evanston, IL

Rebecca A. Jockusch
University of Toronto
Member at Large for Publications

Secretary
Rachel O. Loo
University of California-Los Angeles
Los Angeles, CA

Member at Large for Education
Gavin E. Reid
Michigan State University
East Lansing, MI

David C. Muddiman
North Carolina State University

Member at Large for Publications
Evan Williams
University of California-Berkeley
Berkeley, CA

Member at Large for Digital
Communications
Michael J. MacCoss
University of Washington
Seattle, WA

PAGE 6					

Staff
Judith A. Sjoberg, Executive Director
Jennifer Watson
Cindi Lilly, Miquela Sena
Marin Walker, Brent Watson

61ST ASMS CONFERENCE ON MASS SPECTROMETRY

ASMS INTEREST GROUPS AND COMMITTEES

Interest Group Coordinators
Analytical Lab
Managers

Nathan Dalleska
David Friedman

Bioinformatics for MS Lucas Kall
		 Brian Searle
Clinical Chemistry Cory Bystrom
		 Brett Holmquist
DNA/RNA Fenyu Meng
		
Norman Chiu
Drug Metabolism &
Pharmacokinetics

Don McKenzie
Chandra Prakash

Energy, Petroleum & Michael McGinley
Biofuels Wolfgang Schrader
Environmental
Applications

Kerry Peru

Flavor, Fragrance and
Foodstuff

Marc Engel

FTMS Franklin Leach
		
Amy McKenna
Fundamentals George Khairallah
		 Glen Jackson
Hydrogen Exchange
& Covalent Labeling

Lars Konermann
David Schriemer

Imaging MS Timothy Garrett
		 Miam McDonnell
Ion Mobility MS

Matthew Bush

LC/MS Related Topics Susan E. Abbatiello
		 Helene Cardasis
Metabolomics Gary Patti
		 Paul West
Metal Ion Coordination Jinhua Ren
Chemistry Mike Van Stipdonk
Peptide Fragmentation Nick Polfer
		 Sharon Pitteri
Pharmaceuticals Matthew Blatnik
		 Brian Furmanski
Polymeric Materials William Erb
		 Gyorgy Vas
Protein Therapeutics Sheng Gu
		 Justin Sperry
Quantitative Intact
Proteomics
Regulated Bioanalysis
Undergraduate
Research in MS

Edward Dratz
Julian Whitelegge
Fabio Garofolo

Committees
Asilomar
Conference
		
		

Glen Jackson, Chair
Carolyn Cassady
Scott McLuckey
Ryan Julian

Lance Nicolaysen, Chair
Scott McLuckey
Carol Harp, Agilent Technologies
Andrew Herman, Imtakt
Carla Marshall-Waggett, New
Objective
		 Bez Moghadam, Thermo Scientific
		 Qihui Ni, EMD Millipore
		 Jon Speak, AB Sciex
Corporate
Liaison
		
		
		

Digital
Communications
		
		
		

Michael MacCoss, Chair
Nuno Bandeira
Mike Lee
Bin Ma
Nathan Yates

Education
		
		
		
		

Gavin Reid, Chair
Dieter Dorrestein
Michael Fitzgerald
Jennifer Grant
Elaine Marzluff

Nominating
		
		
		
		

Alan Marshall, Chair
Julia Laskin
Joseph Loo
Christine Miller
Nathan Yates

Publications
		
		
		
		
		

Evan Williams, Chair
Carthene Bazemore-Walker
Lars Konermann
Brandon Ruotolo
Yu Xia
Michael Gross (ex officio)

Sanibel Lisa Deterding, Chair
Conference Neil Kelleher
		 J.C. Poutsma
			Jon Williams

Archivist
Michael Grayson

J.C. Poutsma

Young Mass Dian Su
Spectrometrists Bick Vu

61ST ASMS CONFERENCE ON MASS SPECTROMETRY						

PAGE 7

GENERAL
ASMS AWARDS
INFORMATION

Award

for a

Distinguished Contribution

in

Mass Spectrometry

2013 Recipient: Richard D. Smith
Award Lecture: 4:45 pm, Monday, Exhibit Hall A (lower level)

The increasing role of mass spectrometry (MS) in the physical and biological sciences can be
attributed in a large part to the versatility afforded by the growing number of ionization methods
and to mass spectrometry’s increasing sensitivity. The development of the electrodynamic ion
funnel in the laboratory of Dr. Richard Smith has been an important factor in the latter increase.
The ion funnel was originally created in the Smith lab in 1997 to replace ion transmission-limited
skimmers and to efficiently capture ions in the expanding gas jet while radially focusing them.
It has been adapted for a variety of uses and has proven to be a broadly applicable tool for
ion focusing and manipulation at elevated pressures that challenged conventional approaches.
Although it has undergone several iterations in the last 15 years, the defining features of the ion
funnel have not changed: closely spaced ring electrodes of gradually decreasing inner diameter,
out-of-phase RF potentials applied to adjacent electrodes, and a longitudinally-applied DC
gradient. The ion funnel concept continues to be adapted in a growing number of applications
such as ion trapping, ion cooling, low pressure electrospray, and ion mobility spectrometry;
however, its original use, decreasing ion losses in the interface of high pressure sources, has
remained its most prevalent. Currently, the funnel is employed by Bruker Daltonics’ and Agilent
Technologies and similarities can be seen in Thermo-Fisher’s recent S-lens design found on the
newer generations of Orbitrap instruments. In the ion funnel, Dr. Smith’s obsession with sensitivity has provided a basis to greatly
improve mass spectrometers, today allowing routine detection of low concentration species that would have been undetectable
15 years ago.
Dr. Richard Smith is Battelle Fellow and Chief Scientist in the Biological Sciences Division and Director of Proteomics Research at
Pacific Northwest National Laboratory (PNNL).

Biemann Medal

2013 Recipient: Yinsheng Wang
Award Lecture: 4:45 pm, Tuesday, Exhibit Hall A (lower level)
Dr. Yinsheng Wang has focused his research on discovering the biological consequences of
DNA damage and on unraveling mechanisms of action for anti-tumor drugs and environmental
toxicants. His laboratory’s use and development of mass spectrometry, synthetic organic
chemistry, biochemistry and molecular biology enables us to understand and quantify, at the
molecular level, how various DNA damage products are repaired, and how they perturb the
efficient flow and fidelity of genetic information during DNA replication and transcription.
Professor Wang has identified and characterized new DNA lesions, including bulky lesions
induced by reactive oxygen species. His laboratory developed LC-MS/MS combined with a
plasmid-based shuttle vector to quantitatively assess how structurally defined DNA lesions
alter the frequency and efficiency of DNA replication and transcription in cells, and to measure
the types and frequencies of mutations induced by lesions. They also discovered that N-2(1-carboxyethyl)-2’-deoxyguanosine (N-2-CEdG) is the major stable DNA adduct derived from
methylglyoxal, and demonstrated that it is the previously unknown endogenous substrate for
DinB (polymerase IV). Dr. Wang’s new methods have provided some long-sought biomarkers
for oxidative stress: cyclopurine lesions including 8,5’-cyclo-2’-deoxyadenosine and 8,5’-cyclo2’-deoxyguanosine.
Dr. Yinsheng Wang is Professor of Chemistry at the University of California-Riverside.

PAGE 8					

61ST ASMS CONFERENCE ON MASS SPECTROMETRY

ASMS RESEARCH AWARDS

The Research Awards are fully funded by Thermo Scientific and Waters Corporation in the amount of $35,000 each.
Awards will be presented at the Biemann Medal Award Lecture, 4:45 pm, Tuesday, Exhibit Hall A
Sponsored by
Thermo Scientific

Sponsored by
Waters Corporation

Yu Xia

Matthew F. Bush

Purdue University
Call

University of Washington
for

2013 Research Award Proposals

Objective

To promote academic research by young scientists in mass spectrometry.

Eligibility

Open to academic scientists within four years of joining the tenure-track or research faculty in a North American
university. Applicants may not have previously received an award under this program.

Application Applicants should submit the following no later than November 30.
			
1. Three-page proposal, including references and figures
			
2. One-page fiscal proposal and justification
			
3. List of current research support
			
4. Curriculum vitae
			
5. Two letters of recommendation may be e-mailed directly to ASMS: office@asms.org
Deadline
Fiscal
Information

Application materials 1-4 should be arranged in order and assembled as one PDF and emailed to office@asms.org.
File may not exceed 5 MB.
The awards of $35,000 each will be made to a university in the name of the selected individual for the researcher’s
exclusive use. In accepting this award, the institution will agree to not charge overhead on the funds.
Contact ASMS. Telephone: (505) 989-4517

Ron Hites Award

for

l

office@asms.org

Outstanding Research Publication

in

JASMS

The Ron Hites Award recognizes an outstanding presentation of original research. Selection is based on a paper’s
innovative aspects, technical quality, likely stimulation of future research, likely impact on future applications, and
quality of presentation. The award is named in honor of Professor Ron Hites of Indiana University, who led the
creation of JASMS in 1988 while president of ASMS. The corresponding author receives a cash award of $2,000
and all authors are acknowledged with certificates of commendation.
The Ron Hites Award recognizes an
outstanding presentation of original
research. Selection is based on a
paper’s innovative aspects, technical quality, likely
stimulation of future research, likely impact on future
applications, and quality of presentation. The award
is named in honor of Professor Ron Hites of Indiana
University, who led the creation of JASMS in 1988
while president of ASMS. The corresponding author
receives a cash award of $2,000 and all authors are
acknowledged with certificates of commendation.

Left to right: Steven J. Ray,
Gary M. Hieftje, and
Alexander W. G. Graham

The 2013 award recognizes Alexander W. G. Graham; Steven J. Ray;
Christie G. Enke; Charles J. Barinaga; David W. Koppenaal; Gary M.
Hieftje for “First Distance-of-Flight Instrument: Opening a New Paradigm
in Mass Spectrometry;” J Am Soc Mass Spectrom 2011, 22, 110-117.
Charles J. Barinaga, David W. Koppenaal, and
Christie G. Enke

61ST ASMS CONFERENCE ON MASS SPECTROMETRY						

PAGE 9

MINNEAPOLIS
GENERAL
CONVENTION
INFORMATION
CENTER

Workshops
‘F’ Sessions

Posters/Exhibits

‘G’ Sessions

‘H’ Sessions

‘D’ Sessions
‘C’ Sessions

‘E’ Sessions

Plenary Sessions
‘A’ Sessions

‘B’ Sessions

PAGE 10					

61ST ASMS CONFERENCE ON MASS SPECTROMETRY

POSTER/EXHIBIT HALL

61ST ASMS CONFERENCE ON MASS SPECTROMETRY						

PAGE 11

GENERAL
INFORMATION
HILTON MINNEAPOLIS
HOTEL
- HOSPITALITY SUITES

PAGE 12					

61ST ASMS CONFERENCE ON MASS SPECTROMETRY

ASMS CORPORATE MEMBERS

						
Company
Booth

Poster or
Tabletop

Hilton Minneapolis
Hospitality Suite

Breakfast Seminar

1st Detect.............................................................33.............. Poster
AB SCIEX............................................................139.................................... Symphony Ballroom........ Mon/Tues/Wed, 7:15 am
Conv Center
		
Room 200DE
		
Room 200GF (Mon only)
		
Room 208AB (Mon/Tues)
Hilton Minneapolis
		
Symphony Ballroom
Advanced Chemistry Development (ACD/Labs)..66.............. Poster.....................................................Monday, 7:00 am
Conv Center, Room 200C
Advion.................................................................123
Agilent Technologies............................................109............. Poster............. Grand Ballroom ABC...... Mon/Tues/Wed, 7:00 am
Conv Center, Room 205AB
Alliance Pharma, Inc............................................34.............. Poster
Analytical Sales & Services.................................125............. Poster
Analytical Scientific Instruments...........................19
Anasys Instruments..............................................82
Antec...................................................................144............. Poster
Apricot Designs, Inc.............................................78
Ardara Technologies LP.......................................64.............. Poster
Avanti Polar Lipids, Inc.........................................21
Bertin Technologies..............................................11
Biocompare, American Laboratory.........................................Tabletop
Biocrates Life Sciences.......................................164
Bioinformatics Solutions Inc................................102............. Poster
Bioreclamation.....................................................128............. Poster
Biotage................................................................122............. Poster.....................................................Tuesday, 7:00 am
Conv Center, Room 200J
Bonna-Agela Technologies Ltd.............................84
Bruker Daltonics..................................................110 ................................... Conrad............................Mon/Tues, 7:00 am
Conv Center, Room 205CD
C&EN.....................................................................................Tabletop
CAMAG Scientific, Inc.........................................116
Cambridge Isotope Labs.....................................107
Canadian Life Science.........................................77.............. Poster
CDS Analytical........................................................................Poster
Cell Signaling Technology...................................100
Cerno Bioscience.................................................96
CETAC Technologies...........................................170
Chemyx, Inc........................................................149............. Poster
Chiral Technologies, Inc.......................................91.............. Poster
ChromTech, Inc....................................................99
Conquer Scientific................................................40
CovalX..................................................................67
CSS Analytical Co., Inc........................................95
CTC Analytics......................................................175
Dani Instruments..................................................48
Denator AB...........................................................76.............. Poster
Detector Technology, Inc......................................55
Deurion...................................................................................Poster
Digital Proteomics................................................35
Dikma Technologies.............................................17

61ST ASMS CONFERENCE ON MASS SPECTROMETRY						

PAGE 13

ASMS
GENERAL
CORPORATE
INFORMATION
MEMBERS

						
Company
Booth

Poster or
Tabletop

Hilton Minneapolis
Hospitality Suite

Breakfast Seminar

Drummond Scientific...........................................168
EBARA Technologies...........................................150............. Poster
Edwards..............................................................173
EMCO High Voltage Corporation.........................57
EMD Millipore.......................................................85.............. Poster.....................................................Tuesday, 7:00 am
Conv Center, Room 200H
Excellims Corporation..........................................59.............. Poster
Expedeon.............................................................58
ExSAR Corporation
Extrel CMS...........................................................56
FLIR Systems, Inc................................................37
Fluid Management Systems................................165............. Poster
Fortis Technologies...............................................87.............. Poster
Frontage Laboratories, Inc..................................157
Genedata..............................................................46..................................... Rochester
Genetic Engineering & Biotechnology News.......................... Tabletop
Genovis...............................................................113............. Poster
GenTech Scientific Inc.........................................176
GERSTEL, Inc.....................................................140............. Poster
GL Sciences.........................................................90
Glygen Corp.........................................................44.............. Poster
GMI, Inc................................................................47
Hamamatsu Corporation.....................................161............. Poster
Hamilton Robotics................................................25
Harvard Apparatus...............................................61
Honeywell Burdick & Jackson.............................105
Horizon Technology Inc........................................20
Hudson Surface Technology.................................72.............. Poster
IAEA Careers........................................................22
iChrom Solutions.................................................151
IDEX Health & Science........................................89.............. Poster
Institute for Systems Biology...............................171
Integrated Analysis, Inc.......................................117
Integrated Proteomics Applications Inc................52
International Equipment Trading Ltd...................135
International Labmate.............................................................Tabletop
inVentiv Health Clinical.........................................13
ionBench..............................................................16
IONICS Mass Spectrometry................................129............. Poster
IonSense, Inc......................................................142............. Poster
ITT Exelis.............................................................145............. Poster
Jaytee Biosciences Ltd........................................114
JEOL USA, Inc.....................................................29
JPT Peptide Technologies....................................63
Kanomax/MSI.TOKYO.........................................60.............. Poster
LEAP Technologies.............................................166............. Poster
LECO Corporation................................................88.............. Poster............. Duluth.............................Mon/Tues/Wed, 7:00 am
Conv Center, Room 200A
LGC Ltd...............................................................124
LNI Schmidlin.......................................................28
Mac-Mod Analytical..............................................24
MassTech, Inc.....................................................162
Matrix Science.....................................................138
PAGE 14					

61ST ASMS CONFERENCE ON MASS SPECTROMETRY

ASMS CORPORATE MEMBERS

						
Company
Booth

Poster or
Tabletop

Hilton Minneapolis
Hospitality Suite

Breakfast Seminar

McKinley Scientific..............................................152
MestreLab Research...........................................126
Microsaic Systems PLC.......................................70.............. Poster............. Directors Row 3
Moeller Medical GmbH.........................................26
Morpho Detection Inc formerly Syagen Technology......134
MS Bioworks.......................................................158
MS Noise.............................................................155
MSParts Inc..........................................................79
mSPEC Group......................................................80
nanoLiter, LLC......................................................18
Nest Group, The.....................................................................Poster
New England Peptide...........................................38
New Objective, Inc..............................................153............. Poster.....................................................Tuesday, 6:45 am
Conv Center, Room 200C
NIST.....................................................................68
Nonlinear Dynamics.............................................54
Oerlikon Leybold Vacuum....................................148
OI Analytical.........................................................98.............. Poster
Omni International...............................................103
OPOTEK, Inc.......................................................163
Optimize Technologies........................................120............. Poster
Orochem Technologies Inc...................................73
Owlstone, Inc........................................................97.............. Poster
Pace Analytical Services......................................81
Parker Hannifin.....................................................65.............. Poster
PEAK Scientific Instruments.................................93.............. Poster
PerkinElmer, Inc.................................................. 111.............. Poster............. Marquette IV-VII..............Tuesday, 7:00 am
Conv Center, Room 200GF
Pfeiffer Vacuum....................................................15.............. Poster
Phenomenex, Inc................................................130............................................................................Monday 7:15 am,
Conv Center, Room 200H
Phoenix S & T, Inc...............................................115
PHOTONIS USA...................................................45.............. Poster
Physical Electronics.............................................42
Phytronix Technologies, Inc.................................141
Polymer Factory Sweden AB...............................104
Pressure BioSciences..........................................36
Prolab Instruments GmbH...................................146............. Poster
Promega Corporation..........................................159
Prosolia, Inc..........................................................41.............. Poster
Protea Biosciences Group, Inc............................174.................................... Directors Row 4
Protein Metrics Inc................................................71
Proteome Software...............................................62
Proton Onsite.......................................................50
Rainin Instrument, LLC.........................................32
Research Scientific Services................................51
Resolution Systems, Inc......................................172
Restek Corporation..............................................94
RMI Laboratories LLC..........................................83

61ST ASMS CONFERENCE ON MASS SPECTROMETRY						

PAGE 15

ASMS
GENERAL
CORPORATE
INFORMATION
MEMBERS

						
Company
Booth

Poster or
Tabletop

Hilton Minneapolis
Hospitality Suite

Breakfast Seminar

SAES Getters SpA...............................................27
Sage Science.......................................................31
Sage-N Research, Inc.........................................108
Samin Science Co., Ltd........................................12
Science/AAAS........................................................................Tabletop
Scientific Instrument Services.............................106............. Poster
Scientific Systems, Inc........................................167
SGE Analytical Science.......................................112
Shimadzu............................................................133............. Poster............. Marquette I-III, VIII-IX..... Mon/Tues/Wed, 7:00 am
Conv Center, Room 200B
Sierra Analytics....................................................127
Sigma Life Science..............................................143
Silantes GmbH.....................................................43
SimulTOF Systems of Virgin Instruments Corp....75..................................... Directors Row 2
Spark Holland......................................................147
SpectralWorks Ltd...............................................101
Spectroscopy Magazine......................................118
Spellman High Voltage.........................................74
SPEware Corporation...........................................49
SunChrom GmbH.................................................23
Supelco..................................................................................Poster............. Red Wing
Tandem Labs.......................................................131
Tecan...................................................................156............. Poster.....................................................Monday, 7:00 am
Conv Center, Room 200J
Teledyne Tekmar..................................................14
Texere Publishing...................................................................Tabletop
Thermo Scientific.................................................154.................................... Grand Ballroom EFG...... Mon/Tues/Wed, 7:00 am
Hilton Minneapolis
		
Grand Ballroom EFG
Thursday, 7:00 am
Conv Center, Room 200DE
Thomson Instruments Company.........................119............. Poster
Tomtec.................................................................121
Torion Technologies..............................................86.............. Poster
Tosoh Bioscience.................................................69
TSI Inc..................................................................92
Tymora Analytical Operations..............................136............. Poster
Veritomyx..............................................................30
VICI Valco Instruments........................................160
Voltage Multipliers Inc..........................................39
VRS.....................................................................137
Waters Corporation.............................................132.................................... Grand Ballroom D........... By Invitation Only (2 locations)
Mon/Tues/Wed, 7:00 am
Conv Center, Room 200I
Hilton Minneapolis
		
Grand Ballroom D
Western Analytical Products, Inc............................................Poster
Wiley.....................................................................10
Zef Scientific, Inc...................................................9
Zhejiang Haochuang Biotech...............................53
Zivak Technologies..............................................169............. Poster
PAGE 16					

61ST ASMS CONFERENCE ON MASS SPECTROMETRY

PROGRAM ACKNOWLEDGEMENTS

Jenny Brodbelt
Vice President for Programs
100

years of

Mass Spectrometry

Michael A. Grayson

Student Assistants
Graduate students assist with many aspects of the conference, including registration, oral and poster sessions, and the employment
center. The students each receive a stipend to help with their conference travel expenses.
Program Committee
Steve Beu
Dave Black
David Burinsky
Saiful Chowdhury
Mark Emmett
Karin Keller

Joe Loo
Yehia Mechref
Hamid Mirzaei
Carol Nilsson
Steven Patrie
Laszlo Prokai

Dave Russell
Kevin Schug
Touradj Solouki
Lloyd Sumner
Jan Sunner
John Yates

Session Chairs
Susan Abbatiello
Luke Ackerman
Peter Armentrout
Erin Baker
Franco Basile
Carthene Bazemore
Mark Bier
Veronica Bierbaum
Jim Bruce
Dave Burinsky
Nadja Cech
Michelle Cilia
Pierre Chaurand
Paul Chiarelli
Ileana Cristea
Heather Desaire

Eric Dodds
Mark Emmett
Ben Garcia
David Goodlett
Mike Grayson
Sheng Gu
Kicki Hakansson
David Hambly
Adrian Hegeman
Thomas Jorgensen
Steven Kass
Neil Kelleher
Karin Keller
Walter Korfmacher
Joseph Loo
Michael McGinley

John McLean
Yehia Mechref
Fanyu Meng
Hamid Mirzaei
Katalin Medzihradszky
David Muddiman
Carol Nilsson
Steve Patrie
Kerry Peru
Karen Phinney
Chandra Prakash
Laszlo Prokai
Kevin Schey
Brian Searle
Jim Shen
Paul Thomas

Natalia Tretyakova
Yury Tsybin
Tracie Williams
David Russell
Mary Satterfield
Kevin Schug
Justin Sperry
David Stranz
Lloyd Sumner
Jack Syage
Richard Vachet
Gary Van Berkel
Mike Van Stipdonk
Guido Verbeck
David Weis
Justin Wiseman

Workshop Organizers
Susan Abbatiello
Matthew Blatnik
Matthew Bush
Cory Bystrom
Helene Cardasis
Norman Chiu
Nathan Dalleska
Edward Dratz
Marc Engel
William Erb

David Friedman
Fabio Garofolo
Timothy Garrett
Sheng Gu
Brett Holmquist
Chrisi Hughey
Glen Jackson
Lucas Kall
George Khairallah
Lars Konermann

Franklin Leach
Yishai Levin
Liam McDonnell
Michael McGinley
Amy McKenna
Luis Mendoza
Fanyu Meng
Kerry Peru
Sharon Pitteri
Nick Polfer

61ST ASMS CONFERENCE ON MASS SPECTROMETRY						

JC Poutsma
Chandra Prakash
Jianhua Ren
David Schriemer
Brian Searle
Mike Van Stipdonk
Justin Sperry
Dian Su
Gyorgy Vas
Bich Vu
Julian Whitelegge

PAGE 17

GENERAL
PROGRAMINFORMATION
OVERVIEW

Saturday
9:00 am - 4:30 pm
2:00 - 5:00 pm

Short Courses
Registration
Sunday

9:00 am - 4:30 pm
10:00 am - 8:00 pm
5:00 - 6:30 pm

Short Courses
Registration
Tutorial Lectures, Exhibit Hall A (lower level)
5:00 - 5:45 pm
A Wide Spectrum: Clinical Diagnostics for the Masses
Andrew Hoofnagle
University of Washington

5:45 - 6:30 pm
The Nuts and Bolts of Protein Hydrogen Exchange MS
John Engen
Northeastern University

6:45 - 7:45 pm

Conference Opening, Exhibit Hall A (lower level)
Jenny Brodbelt, ASMS Vice President for Programs

Welcome, Jenny Brodbelt, University of Texas, Austin
ASMS Vice President for Programs
Then...

Now...

The First Fifty Years of MS: Building a Foundation
Michael L. Gross
Washington University of St. Louis
7:45 - 9:00 pm

Reception

in the

Poster-Exhibit Hall, Exhibit Hall BC

PAGE 18					

61ST ASMS CONFERENCE ON MASS SPECTROMETRY

PROGRAM OVERVIEW

Monday
7:30

- 5:00

pm

Registration

8:30 - 10:30

am

Oral Sessions
• MOA am
Quantification of Targeted Proteins and Post-Translational Modifications,
Exhibit Hall A (lower level)
Instrumentation: Time-of-Flight Mass Spectrometry: In Memory of Robert J. Cotter,
• MOB am
Room L100 (lower level)
FAIMS and DMS: New Developments and Applications, Ballroom B
• MOC am
• MOD am
Biotherapeutics and Biomarkers: Advances in Quantitative Analysis, Ballroom A
• MOE am
Integrated Qualitative and Quantitative LC-MS for Small Molecule Analysis,
Auditorium
• MOF am
Covalent Labeling, Chemical Probes, and Crosslinking for Biomolecule Structural
Characterization, Room 101
• MOG am Fundamentals of Peptide Fragmentation, Room 102
• MOH am
Nucleic Acids, Room 103

- 2:30

pm

Poster Session

2:30 - 4:30

pm

Oral Sessions
• MOA pm
PTMs: Comprehensive Analysis, Exhibit Hall A (lower level)
• MOB pm
Top-Down and Middle-Down Protein Analysis (Honoring Fred McLafferty’s 90th
birthday), Room L100 (lower level)
• MOC pm
Clinical Chemistry: Dried Blood Spot Analysis, Ballroom B
Biotherapeutics, Impurities and Degradants: Structural Characterization, Ballroom A
• MOD pm
• MOE pm
High Mass Accuracy in Drug Discovery and Development, Auditorium
• MOF pm
Protein-Protein and Protein-Ligand Interactions, Room 101
• MOG pm Fundamentals of Ion Activation and Dissociation, Room 102
• MOH pm
Photoionization, Room 103

4:45 - 5:30

pm

Award Lecture, Exhibit Hall A

10:30

am

am

and

Exhibits, Exhibit Hall BC

Award for a Distinguished Contribution in Mass Spectrometry
Richard D. Smith
Pacific Northwest National Laboratory

5:45 - 7:00

pm

Workshops There are light refreshments on level two.
•
•
•
•
•
•
•
•
•
•
•

Level One Rooms
The Informatical Difference between Targeted and Discovery-based Proteomics (organized by the
Bioinformatics for MS Interest Group), Room 1
Have Recent LC-MS Techniques Advanced to Substitute AMS in Analyzing Microdose and other Low Level
Clinical Studies for Metabolites and Drug Related Material? (organized by the DMPK Interest Group),
Room 2
Trans-Proteomic Pipeline (TPP) and Related Open-Source Proteomics Resources, Room 3
Level Two Rooms
FRAGILE Modifications, Handle with Care during Peptide Fragmentation (organized by the Peptide
Fragmentation Interest Group), Room 200 DE
Mass Spectrometry-based Characterization of Biotherapeutics (organized by the Protein Therapeutics
Interest Group), Room 200 FG
How Can MS Analysis Be Used to Improve Analytical Results and Laboratory Efficiency (organized by the
Flavor, Fragrance and Foodstuff Interest Group), Room 200 H
Nucleic Acids as Diagnostic and Therapeutic Biomarkers (organized by the DNA/RNA Interest Group),
Room 200 I
Surviving and Thriving: A Panel Discussion for Both Students and PUI Faculty on How to Get the Most out of
Undergraduate Research (organized by the Undergraduate Research in MS interest Group), Room 205 AB
Photoionization Mass Spectrometry, Room 205 CD
Consortium for Top Down Proteomics, Room 208 AB
Data Independent Acquisition, Room 208 CD

7:00 - 8:00

pm

Dinner Break

After 8:00

pm

Corporate Hospitality Suites, Hilton Hotel

61ST ASMS CONFERENCE ON MASS SPECTROMETRY						

PAGE 19

GENERAL
PROGRAMINFORMATION
OVERVIEW

Tuesday
7:30

- 5:00

pm

Registration

8:30 - 10:30

am

Oral Sessions
• TOA am
• TOB am
• TOC am
• TOD am
• TOE am
• TOF am
• TOG am
• TOH am

- 2:30

pm

Poster Session

2:30 - 4:30

pm

Oral Sessions
•
TOA pm
Instrumentation and Methods: FT, Ion Traps and Hybrid Instruments, Exhibit Hall A
(lower level)
•
TOB pm
Imaging MS: Biological Applications, Room L100 (lower level)
Characterization of Product Variants in Biosimilars, Ballroom B
•
TOC pm
Phosphoproteomics, Ballroom A
•
TOD pm
Food Safety: Advances in MS for Characterization of Additives and Contaminants,
•
TOE pm
Auditorium
Ion Mobility: Structures, Room 101
•
TOF pm
Metabolites: Unusual and Uncommon, Room 102
•
TOG pm
•
TOH pm
Microorganisms: Identification and Characterization, Room 103

4:45 - 5:30

pm

Award Lecture, Exhibit Hall A, Lower Level

10:30

am

am

Quantitative Proteomics, Exhibit Hall A (lower level)
Imaging MS: Increasing Speed and Information Content, Room L100 (lower level)
Functional Foods, Phytochemicals, and Supplements, Ballroom B
PTMs: Glycosylation, Ballroom A
Systems Biology/Cellular Pathways, Auditorium
Metabolomics/Lipidomics: New MS Technologies and Applications, Room 101
Ion Mobility: Separations, Room 102
Antibodies and Antibody-Drug Conjugates, Room 103
and

Exhibits, Exhibit Hall BC

Biemann Medal
Yinsheng Wang
University of California, Riverside

5:45 - 7:00

pm

Workshops There are light refreshments on level two.
•
•
•
•
•
•
•
•
•
•
•

Level One Rooms
Environmental Applications of FTMS: Earth, Air & Water (organized by the FTMS Interest Group), Room 1
Jumpstarting Your Career: a Career Development Workshop (organized by the Young Mass
Spectrometrists Interest Group), Room 2
The Galaxy Framework as a Solution for MS-based Informatics, Room 3
Level Two Rooms
LC-MS in the Clinical Lab: How Close is 24/7? (organized by the Clinical Chemistry Interest Group),
Room 200 DE
Normalization Approaches to Imaging Mass Spectral Data (organized by the Imaging MS Interest Group),
Room 200 FG
How to Work with your P.I.s More Effectively (and Without Them Knowing It) (organized by the Analytical
Lab Managers Interest Group), Room 200 H
Current Topics in Metal Ion Chemistry (organized by the Metal Ion Coordination Chemistry Interest Group),
Room 200 I
Ion Mobility MS: New Instrumentation & Enabling Technologies (organized by the Ion Mobility MS Interest
Group), Room 205 AB
Quantitative Intact Proteomics (organized by the Quantitative Intact Proteomics Interest Group),
Room 205 CD
Large Molecule by LC-MS Bioanalytical Method Validation (BMV): Status, Challenges, Solutions,
Recommendations (organized by the Regulated Bioanalysis Interest Group), Room 208 AB
Practical ETD, Room 208 CD

7:00 - 8:00

pm

Dinner Break

After 8:00

pm

Corporate Hospitality Suites, Hilton Hotel

PAGE 20					

61ST ASMS CONFERENCE ON MASS SPECTROMETRY

PROGRAM OVERVIEW

Wednesday
7:30

- 5:00

pm

Registration

8:30 - 10:30

am

Oral Sessions
•
WOA am PTMS: Advances in Isolation, Derivatization and Separation,
Exhibit Hall A (lower level)
•
WOB am Informatics: Protein Quantification, Room L100 (lower level)
•
WOC am Carbohydrates: New MS Approaches, Ballroom B
•
WOD am Quantitative Analysis by MS in Drug Discovery and Development: Novel
Approaches, Ballroom A
•
WOE am Instrumentation: New Developments in High Resolution and Mass Accuracy,
Auditorium
•
WOF am Emerging Environmental Contaminants, Room 101
•
WOG am Fundamentals: Ion Spectroscopy (Honoring Rob Dunbar’s 70th Birthday), Room 102
•
WOH am H/D Exchange: Biological Applications, Room 103

- 2:30

pm

Poster Session

2:30 - 4:30

pm

Oral Sessions
•
WOA pm
•
WOB pm
•
WOC pm
•
WOD pm

10:30

am

am

•
•
•
•

WOE pm
WOF pm
WOG pm
WOH pm

and

Exhibits, Exhibit Hall BC

Forensic Applications, Exhibit Hall A
Principles of Protein Identification and Characterization, Room L100
Gas-Phase Ions: Reactions, Dynamics and Theory, Ballroom B
Biomarkers of Drug Response, Efficacy and Toxicity: Novel MS Approaches,
Ballroom A
Instrumentation: New Developments in Ionization and Sampling, Auditorium
Ecological and Human Health Environmental Chemistry and Toxicology, Room 101
Glycoproteins and Glycans: New MS Approaches, Room 102
H/D Exchange: New Development in Technology, Room 103

4:45 - 5:30

pm

ASMS Meeting, Ballroom A Awards, board reports, wine, beer, soft drinks - and more!

5:45 - 7:00

pm

Workshops There are light refreshments on level two
•
•
•
•
•
•
•
•
•
•
•
•

Level One Rooms
Fundamentals in LC-MS Troubleshooting (organized by LC/MS & Related Topics Interest Group), Room 1
H/D Exchange and Covalent Labeling (organized by H/D Exchange & Covalent Labeling Interest Group),
Room 2
LC-MS of Glycans and Glycopeptides: Advantages and Challenges, Room 3
Level Two Rooms
Fuel Analysis: Surveying Research Methods and their Application in Industrial Settings (organized by Energy,
Petroleum & Biofuels Interest Group), Room 200 DE
Emerging Contaminants in Environmental Research: Hydraulic Fracturing Fluids and Shale Gas Produced
Waters - Advances, Challenges and Opportunities using mass spectrometry (organized by Environmental
Applications Interest Group), Room 200 FG
The Advancement of Polymer Mass Spectrometry (organized by Polymeric Materials Interest Group), Room
200 H
Challenges and New Directions in Plant Proteomics, Room 200 I
CHORUS – A Community Solution for the Storage, Visualization, and Sharing of Mass Spectrometry Data on
the Cloud, Room 200 J
Ion Structures and Energetics, and Ion-Molecule Reaction Kinetics in the Gas Phase, in honor of Peter B.
Armentrout’s 60th birthday (organized by Fundamentals Interest Group), Room 205 AB
Proteins and Peptides as Pharmaceutical Agents (organized by Pharmaceuticals Interest Group),
Room 205 CD
Lipid Mass Spectrometry & Lipidomics, Room 208 AB
Mass Spectrometry Applications in Art, Cultural Heritage, and Natural History, Room 208 CD

7:00 - 8:00

pm

Dinner Break

After 8:00

pm

Corporate Hospitality Suites, Hilton Hotel

61ST ASMS CONFERENCE ON MASS SPECTROMETRY						

PAGE 21

GENERAL
PROGRAMINFORMATION
OVERVIEW

Thursday
7:00

- 5:00

pm

Registration

8:30 - 10:30

am

Oral Sessions
•
ThOA am
•
ThOB am
•
ThOC am
•
ThOD am
•
ThOE am
•
ThOF am
•
ThOG am

am

•
10:30

am

- 2:30

pm

ThOH am

Poster Session

Ambient Ionization: Instrumentation and Applications, Exhibit Hall A (lower level)
Informatics: Metabolomics, Room L100 (lower level)
Regulated Bioanalysis and Diagnostics using High Resolution LC/MS, Ballroom B
Disease Biomarkers and Pathways, Ballroom A
Space Science, Astrobiology, and Atmospheric Chemistry, Auditorium
Imaging MS: Pharmaceutical Applications, Room 101
Energy, Petroleum, and Biofuels: Advances in MS Design and Informatics,
Room 102
Epigenetic Modifications and Mechanisms, Room 103
and

Exhibits, Exhibit Hall BC

Thursday posters
2:30 - 4:30

pm

Oral Sessions
•
ThOA pm Ambient and Atmospheric Pressure Ionization: Fundamentals, Exhibit Hall A
(lower level)
•
ThOB pm Proteomics: Infection Diseases, Room L100 (lower level)
•
ThOC pm Lipids and Profiling, Ballroom B
•
ThOD pm Biomarkers in Drug Discovery and Development, Ballroom A
•
ThOE pm Plant”omics”, Auditorium
•
ThOF pm Polymer- and Packaging-Related Contaminants and Degradants in Food, Drugs,
and Consumer Products, Room 101
•
ThOG pm Energy, Petroleum, and Biofuels: Advances in Sample Preparation and MS
Interface Design, Room 102
•
ThOH pm History: Celebration of 100th Anniversary of Mass Spectrometry, Room 103

4:45 - 5:30

pm

Plenary Lecture, Exhibit Hall A (lower level)
Discovery of the Elusive Higgs Boson
Peter Onyisi
University of Texas at Austin

5:45 - 9:00

pm

Closing Gala, Ballroom D

PAGE 22					

61ST ASMS CONFERENCE ON MASS SPECTROMETRY

WORKSHOPS

MONDAY WORKSHOPS, 5:45 - 7:00 PM
The Informatical Difference between Targeted and Discoverybased Proteomics (organized by Bioinformatics for MS Interest
Group); Brian Searle and Lukas Käll, presiding
Room 1
Recent developments in data acquisition strategies and instrumentation
have granted proteomicists to the ability to acquire not just the mass
and intensity of the peptides in large-scale proteomics samples, but
also sequence specific fragment ions as well. Informatically speaking,
data independent acquisition facilitates researchers to first form
hypotheses about which proteins are likely to be present in samples
and ask targeted questions to identify them. However, unlike traditional
targeted acquisition, such as with selected reaction monitoring, data is
acquired discovery-based where peptides from all proteins present in
each sample are fragmented indiscriminately. These fragments can be
exploited by informatics informed by database searching strategies.
This workshop will be discussion-driven after both points of view are
briefly introduced.
Have Recent LC-MS Techniques Advanced to Substitute AMS in
Analyzing Microdose and other Low Level Clinical Studies for
Metabolites and Drug Related Material? (organized by DMPK
Interest Group); Chandra Prakash and Don McKenzie, presiding
Room 2
Human micro dose studies require a highly sensitive analytical method
such as Accelerator Mass Spectrometer (AMS). Unfortunately, the
wide implementation of AMS in these analyses has been limited due to
low-throughput sample preparation and high analysis cost. Over the
last two decades, LC coupled with high resolution mass spectrometers
(LC–HRMS) has become a reference analytical method for qualitative
and quantitative analysis of pharmaceuticals. This workshop will
discuss the advantages and disadvantages of LC-HRMS and AMS for
the qualitative and quantitative analysis of drug and metabolites from
low dose studies. The workshop will include 2 speakers (10-15 min
per presentation) followed by Q&A and discussion with the audience.
Trans-Proteomic Pipeline (TPP) and Related Open-Source
Proteomics Resources;
Eric W. Deutsch and Luis Mendoza, presiding
Room 3
This workshop will begin with a tutorial-style presentation on how to
use the freely available and open-source suite of software tools for the
analysis of proteomics shotgun datasets called the Trans-Proteomic
Pipeline (TPP). The presentation will include demonstrations on
use of format conversions, PeptideProphet, iProphet, PTMProphet,
ProteinProphet, and related tools through the TPP graphical user
interface, both in a local installation and on the Amazon EC2 cloud
computing platform. Next we will present examples of how to use other
resources from the Seattle Proteome Center including PeptideAtlas
and SRMAtlas for the planning of targeted proteomics experiments.
The workshop will conclude with an open discussion on use of the
tools, possible improvements, as well as future directions. There will
be an opportunity to talk with the developers of the TPP.
FRAGILE Modifications, Handle with Care during Peptide
Fragmentation (organized by Peptide Fragmentation Interest
Group) Nicolas Polfer and Sharon Pitteri, presiding
Room 200 DE (level 2)
Many post-translational modifications (PTMs) on peptides, such as
phosphorylation or glycation are easily detached during collisioninduced dissociation (CID). This lability seriously complicates the
localization of PTMs in sequencing experiments. This workshop aims
to critically assess this problem for the proteomics community and
to offer solutions to eliminate or at least minimize these redundant
processes.

Mass Spectrometry-based Characterization of Biotherapeutics
(organized by Protein Therapeutics Interest Group); Justin
Sperry and Li Tao, presiding
Room 200 FG (level 2)
To provide a forum to discuss and share new techniques used to
characterize and quantify biotherapeutics in various matrices by mass
spectrometry. We will focus on the daily challenges faced by difficult
samples such as antibodies, antibody-drug conjugates, vaccines,
biosimilars, and/or heavily glycosylated proteins. The workshop
will be a place for scientists to share their experiences in analyzing
these samples by mass spectrometry-based methodologies. The
workshop will also try to stimulate discussion on perspectives of new
technologies that could improve the efficiency/throughputs in analyzing
biotherapeutics.
How Can MS Analysis Be Used to Improve Analytical Results
and Laboratory Efficiency (organized by Flavor, Flavor,
Fragrance and Foodstuff Interest Group); Marc Engel, presiding
Room 200 H (level 2)
The following questions will be addressed:
• How can I use MS to get more accurate results?
• How can MS improve the efficiency of my lab?
• Are there MS techniques that I am not using in my lab that
would improve the analyses that I am performing?
Nucleic Acids as Diagnostic and Therapeutic Biomarkers
(organized by DNA/RNA Interest Group);
Norman Chiu and Fanyu Meng, presiding
Room 200 I (level 2)
The discussion will focus on the mass spectrometry of nucleic acids
biomarkers such as single nucleotide polymorphism (SNP), methylated
DNA, non-coding RNA, and modified nucleosides. The use of these
biomarkers for the diagnosis of diseases and therapeutic applications
will be discussed. Comparison of using mass spectrometry to other
analytical techniques for measuring nucleic acids biomarkers will be
made during the discussion. The panelists of this workshop will include
leaders from both industry and academy.
Surviving and Thriving: A Panel Discussion for Both Students
and PUI faculty on How to Get the Most out of Undergraduate
Research (organized by Undergraduate Research in MS Interest
Group); JC Poutsma and Chrisi Hughey presiding
Room 205 AB (level 2)
A two-part panel discussion will address the rewards and challenges
of undergraduate (UG) research in mass spectrometry. Each panel will
be comprised of 3-4 panelists. The first part of the panel discussion
will focus on how undergraduates can leverage their UG research
experience to set themselves apart during a job search, when applying
for graduate or professional schools and graduate fellowships.
Members of this panel will include ASMS members that participated in
UG research and are currently in graduate school, recently employed
and/or individuals who hire recent grads. The second part of the panel
discussion will focus on faculty concerns. Possible topics include
time management, grant writing and the formation of scholarly writing
support teams. Members of this panel will include beginning, mid- and
late-career faculty.
Photoionization Mass Spectrometry;
Jack Syage and Ralf Zimmerman presiding
Room 205 CD (level 2)
Photoionization based methods are playing an increasingly important
role in mass spectrometry. Among the various benefits of photoionization
processes, their softness and selectivity are the most important ones.
With the on-going improvement of laser based and incoherent light

61ST ASMS CONFERENCE ON MASS SPECTROMETRY						

PAGE 23

WORKSHOPS
GENERAL
INFORMATION

MONDAY WORKSHOPS, 5:45 - 7:00 PM continued

sources a further increase in techniques and applications is to be
expected. The development of photoionization mass spectrometry
(PIMS) based methods is also reflected in the scientific literature: In
2010 in total more than 1200 non-MALDI PIMS papers were published.
The last decade has also seen the commercialization of APPI primarily
for LC/MS and its emergence in important niche areas such as nonpolar compounds, steroids, PAHs, petroleums, food safety, etc. PIMS
is clearly making a practical and major impact in analytical MS. More
recently photoionization mass spectrometers for on-line monitoring
purposes were successfully commercialized.
Consortium for Top Down Proteomics;
Nicolas Young and Ying Ge presiding
Room 208 AB (level 2)
The Consortium for Top Down Proteomics was established in March
2012 with the following mission, “To promote innovative research,
collaboration and education accelerating the comprehensive analysis
of intact proteins”. The consortium exists to bring together disparate
researchers in top down proteomics and to educate the world on the

study of proteins in the intact state. At the ASMS 2013 meeting, we
will review the results of current pilot projects, discuss nomenclature,
data storage and data interchange. We will also review common
roadblocks to successful top down proteomics experiments. A limited
number of 5 minute ‘lightning talks’ will be available for researchers to
provide updates on recent achievements and accomplishments of note.
Contact workshop chairs if you are interested in presenting.
Data Independent Acquisition; Yishai Levin presiding
Room 208 CD (level 2)
In recent years several alternative data acquisition modes have
emerged in ‘bottom-up’ proteomics. Among these, Data Independent
Acquisition (DIA) approaches have raised significant interest due
to their improved identification reproducibility and quantitative
performance. We will discuss the current status of various DIA
approaches and the latest developments in instrumentation and
software. We will host a panel of experts in the field and encourage
discussion throughout the workshop.

TUESDAY WORKSHOPS, 5:45 - 7:00 PM
Environmental Applications of FTMS: Earth, Air & Water
(organized by the FTMS Interest Group);
Amy McKenna and Franklin Leach, presiding
Room 1
This workshop will focus on the application of FTMS to characterize
environmental samples. The discussion will include the requirement for
high resolution FTMS for complex organic mixtures, such as dissolved
organic matter, petroleum and atmospheric samples. We will highlight
the threshold for current capabilities with 3-4 speakers, and will
outline limitations for current techniques. This workshop will combine
presentations with open discussion.
Jumpstarting Your Career: A Career Development (organized by
the Young Mass Spectrometrists Interest Group);
Dian Su and Bich Vu, presiding
Room 2
The workshop will hold panel discussions on personal career
management and planning. The topics will be related to effective
career planning, high impact resumes, job search strategies, power
interviewing, industrial and corporate internships, career pathways
in academia, industry, and government organizations. Recruiters
and representatives from industry, academia, and government
organizations inside and outside the US will be invited to share best
practices on career prospects.
The Galaxy Framework as a Solution for MS-based Informatics;
Tim Griffin, presiding
Room 3
The open source, community-developed, web-based Galaxy framework
enables sharing of software and analysis workflows, promoting
increased transparency in data analysis and adherence to standards.
Originally designed for the genomics research community, Galaxy is
gaining use by those in the MS-based proteomics and metabolomics
community where new informatics solutions are urgently needed.
Galaxy usage is driven by its unique and powerful features, not offered
by other current solutions. This workshop seeks to inform current users
of Galaxy on the newest developments, and introduce the framework
to interested new users. Top developers of Galaxy for MS-based
informatics will give short informal presentations on their work, followed
by a panel discussion and an open question and answer period from
the audience.
LC-MS in the Clinical Lab: How Close is 24/7? (organized by the
Clinical Chemistry Interest Group);
Brett Holmquist and Cory Bystrom, presiding
Room 200 DE (level 2)
Keeping a clinical LC-MS lab running smoothly is a challenge, and
labs employ many strategies to keep hardware running optimally. This

PAGE 24					

workshop will discuss how clinical laboratorians view lab infrastructure,
service agreements, and staff training with an eye toward maximum
productivity.
Normalization Approaches to Imaging Mass Spectral Data
(organized by Imaging MS Interest Group);
Timothy J. Garrett and Liam McDonnell, presiding
Room 200 FG (level 2)
Normalization is commonly used in imaging mass spectrometry to
reduce the impact of fluctuations that can influence peak intensities.
This includes fluctuation in laser intensity (MALDI), primary ion gun
(SIMS), electrospray emitter (DESI), mass spectrometer performance,
and matrix coating inhomogeneities. Normalization approaches can
include the use of the total ion current and/or a single mass-to-charge
value as well as other methods. This interactive workshop will explore
the use of normalization approaches and how the approach modifies
the images produced, positively or negatively.
How to Work with your P.I.s More Effectively (and without Them
Knowing It) (organized by the Analytical Lab Managers Interest
Group); Nathan Dalleska and David Friedman, presiding
Room 200 H (level 2)
Along with a panel of three invited laboratory managers, we propose to
address three topics all related to good outcomes for scientist‐users and
service providers in the mass spectrometry core facility environment.
1) Strategies and Models for Cost Recovery for non‐tangible effort
(e.g., data interpretation and translation). 2) Convincing The Scientist
to do the Right Experiment. Oftentimes researchers arriving in the
Mass Spectrometry lab ready to do some science have neither the
inclination nor funds to do a statistically‐powered experiment. How do
you enter the process from a position of information provider rather
than a salesperson? 3) Recognition for your contribution. This will be
an expansion of last year’s “Who Ran That.” We will begin the session
with a short introduction and perspective (ca. 3 minutes each) from the
panelists, followed by an open discussion of the above topics.
Current Topics in Metal Ion Chemistry (organized by the Metal
Ion Coordination Chemistry Interest Group);
Jianhua Ren and Michael van Stipdonk, presiding
Room 200 I (level 2)
The workshop will serve as an informal venue for active metal ion
researchers to discuss the current challenges and future directions
of the field. Key topics of discussion will include ion formation,
reactivity, structure and energetics studied by mass spectrometry, and
complementary techniques such as ion spectroscopy and ion mobility
as well as calculations. Some of the potential topics include, but are not
limited to, separation and quantification of metalloproteins, structural
elucidation of bio-mimicking systems, structures and reactions of metal

61ST ASMS CONFERENCE ON MASS SPECTROMETRY

WORKSHOPS

TUESDAY WORKSHOPS, 5:45 - 7:00 PM continued

clusters, micro-solvation of metals, and solving problems in metal ion
chemistry using mass spectrometry experiments and theory. Those
who wish to learn more about metal ion chemistry (especially young
scientists) are strongly encouraged to attend.
Ion Mobility MS: New Instrumentation & Enabling Technologies
(organized by the Ion Mobility MS Interest Group);
Matthew Bush, presiding
Room 205 AB (level 2)
The performance of conventional and differential ion mobility mass
spectrometers has escalated dramatically in recent years, which can
be attributed to improved separations, more efficient ion transfer, and
tighter integration of ion mobility devices into hybrid instruments. These
improvements enable intricate and sensitive experiments probing
mobility selected or separated ions, which has led to the adoption of
ion mobility technologies in a wide range of applications, including
challenges in gas-phase ion structure determination, native mass
spectrometry, proteomics, and systems biology. We will showcase the
latest developments in ion mobility mass spectrometry instrumentation
and discus remaining challenges.
Quantitative Intact Proteomics (organized by the Quantitative
Intact Proteomics Interest Group);
Edward Dratz and Julian Whitelegge, presiding
Room 205 CD (level 2)
A continuation of the open forum format started three years ago will
include discussion directed by topics submitted to the QIP Interest
Group ahead of time. The major focus of this workshop will be on
quantitative methods used for intact proteins: 2D gel-based (DIGE)
using fluorescent tags, multiplexing and internal standards; Top-down
using GelFree-type separations etc. The goal is to achieve crossfertilization between different areas of the community with respect to
experimental design, power analysis, multivariate statistical analysis,
and fitness for purpose.

Large Molecule by LC-MS Bioanalytical Method Validation (BMV):
Status, Challenges, Solutions, Recommendations (organized by
the Regulated Bioanalysis Interest Group);
Steve Lowes and Fabio Garofolo, presiding
Room 208 AB (level 2)
LBA are currently the most popular approach to Large Molecule
Bioanalysis. However, recent developments in LC-MS instrumentation
is evolving as a viable technique for the accurate quantitation of
therapeutic proteins and large peptides in biological fluids by offering
a valid alternate to LBA. LC-MS in quantification of biologics has
many advantage such as no needs for high affinity reagent; uniform
approach; large linear range; higher selectivity and expected to be
well accepted by regulatory agencies. It is commonly performed by
using tryptic digestion, then purifying and detecting one or smaller
signature peptides by LCMS. The analysis of these signature peptides
can be very challenging since they can interact/adsorb strongly with
both plastic and glass surfaces. Preparation techniques for both intact
proteins and signature peptides purification are quickly evolving based
on conventional techniques and immunoaffinity-based. Sensitivity and
selectivity could also be difficult to achieve even when using the most
advanced LC-MS. This workshop will focus on discussing the most
recent developments in large molecule quantification in Regulated
Bioanalysis by LC-MS highlighting the challenges faced during the
method development, validation, samples analysis.
Practical ETD;
Katalin F. Medzihradszky and Robert Chalkley, presiding
Room 208 CD (level 2)
ETD is a relatively young technique. Discussion will focus on
i) the available search engines – advantages and drawbacks;
ii) unusual/unexpected fragmentations;
iii) combination of ETD with other dissociation methods;
iv) derivatizations
v) intact protein analysis

WEDNESDAY WORKSHOPS, 5:45 - 7:00 PM
Fundamentals in LC-MS Troubleshooting (organized by LC/MS &
Related Topics Interest Group); Helene Cardasis, presiding
Room 1
This workshop will cover fundamental principles of troubleshooting logic
with the goal of helping attendees reduce LC-MS instrument down time.
We’ll define the terms “primary symptom” and “secondary symptom”
in the context of LC-MS instrumentation problems, and as a group will
work through the identification and resolution of multiple real world
examples. Time will be allowed for ample discussion and questions
for the expert panel, as well as an ‘open mic” - “has anyone seen this?”
therapeutic session of communal troubleshooting of current, ongoing
audience instrument problems.
H/D Exchange and Covalent Labeling (organized by H/D
Exchange & Covalent Labeling Interest Group);
Lars Konermann and David Schriemer, presiding
Room 2
The workshop will provide a forum for discussing HDX and covalent
labeling approaches for protein analysis (structure, function, folding,
dynamics). There will be a number of brief presentations introducing
new advances in MS-based methods, experiments, data analysis
and applications to the attendees. The goal of these presentations (5
min maximum) will be to stimulate discussion. The workshop will also
contain a question and answer session, with questions being submitted
in advance.
LC-MS of Glycans and Glycopeptides: Advantages and
Challenges; Yehia Mechref and Barry Boyes, presiding
Room 3
The biosynthetic processes controlling the glycosylation of proteins
and lipids invariably result in the formation of multiple glycan structures
(positional and linkage isomers). A variety of glycan structures can

occupy a particular glycosylation site of a protein. Mass spectrometry
alone might not be suited to attain a comprehensive characterization of
all glycans associated with proteins and lipids. Accordingly, separation
techniques in conjunction with mass spectrometry are currently
being employed to define and quantify glycosylation of these many
glycoconjugates. This workshop aims at addressing the advantages
and challenges associated with LC-MS of glycans and glycopeptides.
The discussion will include both condensed and gas phase separations.
The use of different chromatographic modes, such as HILIC and RP, will
be presented and discussed. Ion mobility mass spectrometry provides
additional selectivity opportunities for the characterization of different
glycans, when used both on-line and off-line with LC. Recent advances
in the analysis of glycopeptides, including new formats for enrichment
and separation will be also discussed.
Fuel Analysis: Surveying Research Methods and their Application
in Industrial Settings (organized by Energy, Petroleum & Biofuels
Interest Group); Michael McGinley and Patrick Hatcher, presiding
Room 200 DE
Rapid advances in sample workflows, instrument technologies,
and informatics have revolutionized the elemental information that
one can obtain from petroleum and biofuel samples. Analytical
technologies continue to impact both the industrial process control
of fuel manufacturing as well as the assessing the environmental
impact of fuel accidents. In this interest group workshop discussions
will revolve around the most recently developed analysis methods in
both biofuel and petroleum in the academic setting as well as discusses
the challenges in implementing such advances in an industrial setting.
Finally, industrial stakeholders will discuss unmet analytical needs in
moving energy technologies forward.

61ST ASMS CONFERENCE ON MASS SPECTROMETRY						

PAGE 25

GENERAL
INFORMATION
WORKSHOPS

WEDNESDAY WORKSHOPS, 5:45 - 7:00 PM continued

Emerging Contaminants in Environmental Research: Hydraulic
Fracturing Fluids and Shale Gas Produced Waters - Advances,
Challenges and Opportunities using Mass Spectrometry
(organized by Environmental Applications Interest Group);
Kerry Peru and Xing-Fang Li, presiding
Room 200 FG
The workshop will focus on the challenges facing the environmental
laboratory with emphasis on mass spectrometry analysis of emerging
contaminants. The objective of the workshop is to discuss new
contaminants, analytical strategies and research opportunities. This
year’s workshop will focus on emerging contaminants relating to
hydrofracking and shale gas produced waters, discussions will be
centered on how mass spectrometry can be used to fill the need of
identifying and monitoring these contaminants. We welcome your
questions and input to the discussion.
Advancement of Polymer Mass Spectrometry (organized by
Polymeric Materials Interest Group); William Erb, presiding
Room 200 H
The workshop will include group discussions centered on the following
topics related to synthetic polymers:
• Advancement of Polymer Separations and Chromatography
• New MS capabilities
• Academic and Industrial Applications of Polymer Analysis
Select scientists will give brief presentation (2-3 slides) on applications
related to these topics to seed discussions.
Challenges and New Directions in Plant Proteomics; Michelle
Cilia and Brett Phinney, presiding
Room 200 I
The purpose of the workshop will be to identify and discuss the unique
analytical challenges that are specific to the proteomic analysis of plant
and/or agricultural samples (including insects, plant pathogenic fungi,
bacteria & viruses) . Examples include, but may not be limited to sample
prep, PTM identification, bioinformatics, functional validation and new
technologies. We will select four abstracts from those submitted for
consideration to the Plant Omics Oral Session that were not selected
to be presented during the scientific session. Informal presentations
will be limited to 15 minutes with 5 minutes for discussion. This format
may be adjusted according to the number and quality of the abstracts
we receive for consideration. We will preferentially select student and
postdoctoral presenters to encourage participation and engagement of
junior members of the society.
CHORUS – A Community Solution for the Storage, Visualization,
and Sharing of Mass Spectrometry Data on the Cloud; Michael
MacCoss, Nathan Yates, and Andrey Bondarenko, presiding
Room 200 J
The sharing and public dissemination of mass spectrometry data has
become a major challenge. We would like to present a community
effort to provide a free, professionally developed solution to the mass
spectrometry field’s needs. The application provides a “Google Docs”
type interface optimized for mass spectrometry data. Data can be
uploaded and kept private, shared with a group of collaborators, or
made entirely public. We would like to discuss the motivations for
initiating this effort, demonstrate what has been developed, describe
our current short and long-term plans, obtain feedback, and encourage
the involvement from the ASMS community.
Ion Structures and Energetics, and Ion-Molecule Reaction
Kinetics in the Gas Phase, in honor of Peter B. Armentrout’s 60th
birthday (organized by Fundamentals Interest Group)
Glen Jackson and George Khairallah, presiding
Room 205 AB
In December 2012, IJMS published a special issue edited by Mary
Rodgers and David Clemmer in honor of Peter Armentrout’s 60th

PAGE 26					

Birthday. We plan to honor this special occasion by providing a series
of invited short presentations and discussion on the major research
areas in which Peter has been so influential. In the tradition of the
fundamentals group, senior graduate students and postdoctoral
scholars in research groups associated with ion structure, energetics
and kinetics will give the presentations.
Proteins and Peptides as Pharmaceutical Agents (organized by
Pharmaceuticals Interest Group);
Matthew Blatnik and Carmen Santasania presiding
Room 205 CD
The pharmaceutical industry has made a significant shift towards
macromolecule based therapies. According to a Reuter’s consensus
sales forecast, biologics are predicted to make up the majority of sales
of the top ten best-selling drugs for 2014. The inherent complexity of
macromolecules requires more sophisticated analytical tools, methods,
and knowledge than traditional small molecule based therapeutic
programs. Historically, antigen-antibody capture techniques have been
used to quantify biological targets. While ELISA assays are still the
predominant method for quantitation of biologics, recent emphasis
has been placed on incorporating complimentary LC-MS strategies to
enhance our understanding of biological therapies. This workshop will
introduce this topic with a short presentation meant to capture the field
in its current state; it will open immediately afterwards for panel led
discussion and audience participation. Specific topics may include but
are not limited to sample preparation/handling, LC-MS in general, data
management and regulatory requirements.
Lipid Mass Spectrometry & Lipidomics;
Gavin Reid and Stephen Blanksby, presiding
Room 208 AB
Lipidomics involves the comprehensive analysis of lipids
in biological systems, and determination of their roles in cellular
structure and function in different physiological or pathological states.
Recent advances in the field have been enabled by the development
and application of mass spectrometry strategies for the rapid and
sensitive identification, characterization and quantitative analysis of
the thousands of chemically distinct lipid species that may be present
within a given system of interest.
The primary goal of the inaugural ASMS Lipids and Lipidomics
workshop will be to bring together like-minded people in the field to
gauge the potential interest in establishing an ASMS Interest Group in
this area, as well as to discuss the current status and future needs of the
various mass spectrometry technologies and data analysis strategies
that are associated with worldwide lipidome analysis efforts. This
discussion will be facilitated by several informal presentations, followed
by an extensive discussion period, from several leading researchers in
the field.
Mass Spectrometry Applications in Art, Cultural Heritage, and
Natural History; Mehdi Moini, presiding
Room 208 CD
The purpose of this workshop is to bring together scientists, conservators,
and curators interested in mass spectrometry (MS) applications to art
and cultural heritage objects, as well as natural history specimens. This
will be an interactive workshop in which various subjects relevant to
the application of MS to museums’ specimens will be discussed in a
casual, dialog format. A preliminary list of topics include: 1) Analysis of
proteinaceous and organic specimens such as silk and wool textiles,
leather and animal guts objects, bone and tissues, ink, paper, paint,
coatings, binders, and wood. 2) Analysis of the fundamental factors
that cause degradation of museums’ objects; identification of their
deterioration markers, using degradation markers as clocks for dating
objects, and studying environmental factors that affect deterioration. 3)
Application of MS to paleo-organic matter such as fossilomics, amino
acid racemization, and ancient DNA. 4) To be determined.

61ST ASMS CONFERENCE ON MASS SPECTROMETRY

SUNDAY and MONDAY MORNING ORAL SESSIONS

5:00 - 6:30 PM, SUNDAY
TUTORIAL SESSION
Jenny Brodbelt (University of Texas), presiding
Exhibit Hall A (lower level)

5:00 - 5:45 pm
A Wide Spectrum: Clinical Diagnostics
for the Masses
Andrew Hoofnagle
University of Washington

5:45 - 6:30 pm
The Nuts and Bolts of Protein Hydrogen
Exchange MS
John Engen
Northeastern University

6:45 - 7:45 PM, SUNDAY
CONFERENCE OPENING
Jenny Brodbelt (University of Texas), presiding
Exhibit Hall A (lower level)
Welcome, Jenny Brodbelt, University of Texas, Austin
ASMS Vice President for Programs

Then...

Now...

The First Fifty Years of MS: Building a Foundation
Michael L. Gross
Washington University of St. Louis

7:45 - 9:00 PM, SUNDAY
WELCOME RECEPTION
Exhibit Hall BC
Conference name badge is required.

8:30 – 10:30 AM, MONDAY MORNING
QUANTIFICATION OF TARGETED PROTEINS AND POSTTRANSLATIONAL MODIFICATIONS
Hamid Mirzaei (University of Texas Southwestern), presiding
Exhibit Hall A (lower level)
MOA am 08:30 Data Independent Acquisition with Improved
Precursor Specificity on a Novel Hybrid Orbitrap
(Q-OT-qIT) and a Q-Exactive; Jarrett Egertson1;
Jesse Canterbury2; Dario Amodei3; Richard
Johnson1; Ying Ting1; Gennifer Merrihew1; Michael
Senko2; Reiko Kiyonami2; Andreas Kuehn4; Yue
Xuan4; Brendan MacLean1; Markus Kellman4; Parag
Mallick3; Olga Vitek5; Vlad Zabrouskov2; Michael
MacCoss1; 1University of Washington, Seattle, WA;
2
Thermo Fisher Scientific, San Jose, CA; 3Stanford
University, Stanford, CA; 4ThermoFisher Scientific,
Bremen, Germany; 5Purdue University, West
Lafayette, IN
MOA am 08:50 Using Variable Widths in Q1 Selection Windows
to Improve Data Quality in Data Independent
Acquisition; Christie Hunter; Sean Seymour; AB
SCIEX, Foster City, CA
MOA am 09:10 Simultaneous Protein Targeting and Discovery
Offers Reproducible, Scheduled-Free,
Quantification of Hundreds of Proteins across
Multiple Experiments; Derek J. Bailey; Molly T.
McDevitt; David J. Pagliarini; Michael S. Westphall;
Joshua J. Coon; University of Wisconsin, Madison,
WI
MOA am 09:30 Improving the Quality and Production Timeline
of Influenza Vaccines using Mass Spectrometry;
Tracie Williams; Wanda Santana; Emily Winne;
James Pirkle; John Barr; Centers for Disease
Control and Prevention, Atlanta, GA
MOA am 09:50 Comparative Phosphoproteomic Analysis of
Checkpoint Recovery Identifies Regulators
of the DNA Damage Response; Vincentius A.
Halim1, 2; Monica Alvarez-Fernández2, 4; Yan Juan
Xu3; Melinda Aprelia3; Henk W.P van den Toorn1;
Albert J.R. Heck1; Shabaz Mohammed1; René
H. Medema2, 3; 1Utrecht University, Utrecht, The
Netherlands; 2University Medical Center Utrecht,
Utrecht, The Netherlands; 3Netherlands Cancer
Institute, Amsterdam, The Netherlands; 4Spanish
National Cancer Research Center (CNIO), Madrid,
Spain
MOA am 10:10 Quantitative Site-Specific Profiling of the
Redox Dynamics on Protein Thiols Relevant
to Photosynthesis in Cyanobacteria; Jia Guo1;
Amelia Nguyen2; Yi Qu1; Matthew J. Gaffrey1;
Ronald J. Moore1; David G. Camp II1; Richard
D. Smith1; Himadri B. Pakrasi2; Wei-jun Qian1;
1
Biological Sciences Division, PNNL, Richland, WA;
2
Washington University, St. Louis, MO

61ST ASMS CONFERENCE ON MASS SPECTROMETRY						

PAGE 27

MONDAY
GENERAL
MORNING
INFORMATION
ORAL SESSIONS

8:30 – 10:30 AM
MONDAY MORNING
INSTRUMENTATION: TIME-OF-FLIGHT MASS
SPECTROMETRY
IN MEMORY OF ROBERT J. COTTER
Guido Verbeck (University of North Texas),
presiding
Room L100 (lower level)
MOB am 08:30 Opening: Alfred L. Yergey, National Institutes of
Health
MOB am 08:50 Recapturing Ions after Analysis by FT-TOF:
Toward MSn using TOF; Ryan T. Hilger; Robert E.
Santini; Scott A. McLuckey; Purdue University, West
Lafayette, IN
MOB am 09:10 High Resolution Ion Mobility Conformational
Space Mapping Combined with Time-of-Flight
Mass Spectrometry for Complex Sample
Characterization; Jody May1; Cody Goodwin1;
Ruwan Kurulugama2; George Stafford2; Alexander
Mordehai2; John McLean1; 1Vanderbilt University,
Nashville, TN; 2Agilent Technologies, Santa Clara, CA
MOB am 09:30 Sub-Second CE-ESI-MS using Microfluidic
Devices and a Novel Method for Acquiring High
Speed TOF-MS Data; J. Scott Mellors1; Nicholas
Batz1; Martin Green2; J. Michael Ramsey1; 1University
of North Carolina, Chapel Hill, NC; 2Waters
Corporation, Manchester,UK
MOB am 09:50 High Mass Intact Protein Detection with a Time
and Position Sensitive Pixel Detector in Linear
Time-of-Flight Mass Spectrometry (ToF-MS);
Shane Ellis1; Julia Jungmann1; Donald Smith1; Andras
Kiss1; Chris Retif2; Ron M.A. Heeren1; 1FOM Institute
AMOLF, Amsterdam, Netherlands; 2Omics2Image,
Amsterdam, Netherlands
MOB am 10:10 Demonstration of Constant-Momentum
Acceleration in Zoom-TOF Mass Spectrometry for
Improved Sensitivity in Time-of-Flight Systems;
Elise A. Dennis1; Alexander Gundlach-Graham1;
Steven J. Ray1; Christie G. Enke2; Charles J.
Barinaga3; David W. Koppenaal3; Gary M. Hieftje1;
1
Indiana University Department of Chemistry,
Bloomington, IN; 2University of New Mexico,
Albuquerque, NM; 3Pacific Northwest National
Laboratory, Richland, WA
8:30 – 10:30 AM, MONDAY MORNING
FAIMS AND DMS:
NEW DEVELOPMENTS AND APPLICATIONS
Yves LeBlanc (AB SCIEX), presiding
Ballroom B
MOC am 08:30 Performance of an Ultra-Sensitive u-FAIMS -IMSQTOF Platform for Proteomics Measurements;
Yehia Ibrahim 1; William Danielson1; Mikhail Ugarov2;
Keqi Tang1; William Frazer2; Erin Baker1; Danielle
Toutoungi3; Gordon Anderson1; George Stafford2;
Richard Smith1; 1Pacific Northwest National
Laboratory, Richland , WA; 2Agilent Technologies
Inc., Santa Clara, CA; 3Owlstone Inc., Cambridge,UK
MOC am 08:50 Decreased Gap Width in a Cylindrical FAIMS
Device Improves Performance for Proteomics
Applications; Kristian E. Swearingen; Michael R.
Hoopmann; Robert L. Moritz; Institute for Systems
Biology, Seattle, WA

PAGE 28					

MOC am 09:10 Differential Ion Mobility Spectrometry for the
Investigation of Ion Reactions in Transfer Optics;
Samantha Isenberg; Kyle Stevens; Gary Glish;
University of North Carolina, Chapel Hill, NC
MOC am 09:30 FAIMS/MS/MS as an Emerging Technique for the
Clinical Laboratory; Richard A. Yost1; Christopher
R. Beekman1; Jared J. Boock1; Timothy J. Garrett1;
Julie A. Ray2; Mark M. Kushnir2; Alan L. Rockwood2;
1
University of Florida, Gainesville, FL; 2ARUP
Laboratories, Salt Lake City, UT
MOC am 09:50 FAIMS Mass Spectrometry for the Identification
of Sites of Glycosylation in Flagellin A from
Campylobacter jejuni; Helen Cooper; Sam Xin
Hui; Gloria N. Ulasi; Alistair McIntosh; Andrew J.
Creese; Charles W. Penn; University of Birmingham,
Birmingham,UK
MOC am 10:10 Gas-phase Separation of Drugs and Metabolites
using Modifier-Assisted Differential Ion Mobility
Spectrometry after Liquid Extraction Surface
Analysis; Tiffany Porta; Emmanuel Varesio; Gérard
Hopfgartner; University of Geneva, Geneva , Switzerland
8:30 – 10:30 AM, MONDAY MORNING
BIOTHERAPEUTICS AND BIOMARKERS: ADVANCES IN
QUANTITATIVE ANALYSIS
Sheng Gu (Biogen Idec), presiding
Ballroom A
MOD am 08:30 Evolution of Candidate Biomarkers for Breast
Cancer from Discovery to Large-Scale Assay
Design and Assessment in patient plasma;
Thomas Lau1; Michael Gillette1; Regine Schoenherr2;
Eric Kuhn1; Jeffrey Whiteaker2; Jennifer Ross1; Lola
Fagbami1; Tao Liu3; Pei Wang2; ChenWei Lin2; Dave
Camp3; Francisco Esteva4; Amanda Paulovich2;
Steven Carr1; Richard Smith3; 1Broad Institute,
Cambridge, MA; 2Fred Hutchinson Cancer Research
Center, Seattle, WA; 3Pacific Northwest National
Laboratory, Richland, WA; 4MD Anderson Cancer
Center, Houston, TX
MOD am 08:50 Toward the Absolute Quantification of CSF Tau
Isoforms in the Picogram/Milliliter Range by a
Simple and Cost-Effective Purification and µLCSIM-HRMS; Nicolas Barthélemy1; Christophe Hirtz2;
Jerome Vialaret2; Susanna Schraen-Maschke3;
Nicolas Sergeant3; Guy Lippens4; Isabelle Huvent4;
François Fenaille1; Christophe Junot1; Sylvain
Lehmann2; François Becher1; 1CEA, iBiTec-S/SPI/
LEMM, Gif-sur-Yvette, France; 2LBPC-IRB, CHU de
Montpellier, Montpellier, France; 3Inserm, UMR 837,
Lille, France; 4CNRS, UMR 8576, LGSF, Villeneuve
d’Ascq, France
MOD am 09:10 Mass Analyzer Comparison for Quantitative
and Confirmatory Determination of OPNA
Biomarker Butyrylcholinesterase Peptides from
Human Serum by Liquid Chromatography-Mass
Spectrometry; Caroline Watson1; Melissa Carter2;
Thomas Blake2; Brian Crow2; Brooke Pantazides1;
Rudolph Johnson2; 1ORISE Centers for Disease
Control and Prevention, Atlanta, GA; 2Centers for
Disease Control and Prevention, Atlanta, GA
MOD am 09:30 Determining and Monitoring with Quantitation
the Site-Specific Glycosylation of Proteins in
Serum; Qiuting Hong1; L. Renee Ruhaak1; Suzanne
Miyamoto2; Carlito Lebrilla1; 1Chemsitry, UC, Davis,
CA; 2Comprehensive Cancer Center, UC, Davis, CA

61ST ASMS CONFERENCE ON MASS SPECTROMETRY

MONDAY MORNING ORAL SESSIONS

MOD am 09:50 2D-LC/MS Technique for the Identification of
Proteins in Biological Matrices: Is It Possible
to Do It Quantitatively? Luca Genovesi; Barbara
Marsiglia; Luca Barbero; Merck-Serono, Colleretto
Giacosa, Italy
MOD am 10:10 Development and Application of LC-MS
Methods for the Evaluation of Therapeutic
Oligonucleotides; Michael G. Bartlett; Buyun Chen;
A. Cary McGinnis; University of Georgia, Athens, GA
8:30 – 10:30 AM, MONDAY MORNING
INTEGRATED QUALITATIVE AND QUANTITATIVE LC-MS FOR
SMALL MOLECULE ANALYSIS
Kevin Schug (Univ of Texas at Arlington), presiding
Auditorium
MOE am 08:30 Integrated Quantitative and Qualitative Work-Flow
for in-vivo Discovery Bioanalysis using Hybrid
Quadrupole-Time-of-Flight Mass Spectrometry;
Asoka Ranasinghe; Celia D’Arienzo; Timothy Olah;
Bristol-Myers Squibb Company, Princeton, NJ
MOE am 08:50 Quantitative Monitoring of Tamoxifen Extended
to Forty Metabolites in Human Plasma using LCHR-MS: New Investigation Capabilities for Clinical
Pharmacology; Elyes Dahmane1; Chantal Csajka
1
; Serge Rudaz2; Julien Boccard2; Khalil Zaman1;
Laurent Decosterd1; Eric Genin3; Bénédicte Duretz3;
Maciej Bromirski3; Serge Leyvraz1; Bernard Testa1;
Bertrand Rochat1; 1University Hospital of Lausanne,
CHUV, Lausanne, Switzerland; 2University of Geneva,
Geneva, Switzerland; 3Thermo Fisher, Paris Bremen, European Union
MOE am 09:10 A Quantitative LC-MS Method Allows Rapid
Identification of Fungal Natural Products,
their Biosynthetic Pathways, and Complex
Mechanisms Regulating their Production; Jessica
Albright1; Matthew Henke1; Alexandra Soukup2;
Nancy Keller2; Neil Kelleher1; 1Northwestern
University, Evanston, IL; 2University of Wisconsin,
Madison, WI
MOE am 09:30 Workflow to Validate Compounds Identified
in Enriched Autophagosome Fractions and
Activated Mast Cell by UPLC-MSe; Chad Satori1;
Joseph Koopmeiners1; Jose Antonio RodriguezNavarro2; Audrey Meyer1; Christy Haynes1; Edgar
A. Arriaga1; Joseph J. Dalluge1; 1University of
Minnesota-Twin Cities, Minneapolis, MN; 2Albert
Einstein College of Medicine, Bronx, NY
MOE am 09:50 Integrated High Throughput Quantitative and
Qualitative Approaches for Pharmaceutical
Research with HRMS (QqTOF); Ian Moore1, 1;
Brendon Kapinos2; Hui Zhang2; Veronica Zelesky2;
Rick Schneider2; Gary Impey1; John Janiszewski2;
Loren Olson1; 1AB SCIEX, Foster City, CA; 2Pfizer,
Groton, CT
MOE am 10:10 Evaluation and Integration of Picoliter Dispensing
Technology for LC-MS/MS Analysis of Small
Molecules in High Throughput ADME and PK
Workflows; Brian Furmanski1; Daniela Zima Kropf1;
Jeff Nielsen2; X. Steven Yan1; Ken Ward2; Dennis
Hruby1; Robert Allen1; 1Siga Technologies, Corvallis,
OR; 2Hewlett-Packard Company, Corvallis, OR

8:30 – 10:30 AM, MONDAY MORNING
COVALENT LABELING, CHEMICAL PROBES, AND
CROSSLINKING FOR BIOMOLECULE STRUCUTRAL
CHARACTERIZATION
David Hambly (Amgen, Inc.), presiding
Room 101
MOF am 08:30 Protein-RNA interactions: Large-Scale
Identification of Peptides Crosslinked to RNA
through Database Searches against Entire
Proteomes; Katharina Kramer1; Timo Sachsenberg2;
Saadia Qamar1; Oliver Kohlbacher2; Henning Urlaub1;
1
Max Planck Institute for Biophysical Chemistry,
Göttingen, Germany; 2Eberhard Karls University,
Tübingen, Germany
MOF am 08:50 Structure, Function and Regulation of an
Intact F-type ATPase Revealed by Chemical
Crosslinking and Native Mass Spectrometry; Carla
Schmidt; Carol V. Robinson; University of Oxford,
Oxford, UK
MOF am 09:10 Inter-Subunit Contacts in Prion Oligomers
Studied by Crosslinking of 15N-metabolically
Labeled Prion Proteins; Jason Serpa1; Evgeniy
Petrotchenko1; David Wishart2; Christoph Borchers1,
3 1
; University of Victoria-Genome BC Proteomics
Centre, Victoria, Canada; 2University of Alberta,
Edmonton, Canada; 3Dept of Biochemistry and
Microbiology, U Victoria, Victoria, Canada
MOF am 09:30 Covalent Labeling of Oncogenic HER2-HER3
Tyrosine Kinase Dimers on Lipid Surfaces
Reveals Key Intermolecular Interactions that
Mediate Phosphorylation- Independent Activation;
Timothy Collier 1; John Monsey1; Wei Shen1;
Karthikeyan Diraviyam2; David Sept2; Ron Bose1;
1
Washington University, St. Louis, MO; 2University of
Michigan, Ann Arbor, MI
MOF am 09:50 Monitoring Large Scale Protein Conformational
Changes Using Covalent Protein Footprinting
and Mass Spectrometry; Taylor A. Poor1; Lisa M.
Jones2; Manolo D. Plasencia3; Don L. Rempel4;
George P. Leser1, 5; Michael L. Gross4; Robert A.
Lamb1, 5; 1Northwestern University, Evanston, IL;
2
Indiana University-Purdue University Indianapolis,
Indianapolis, IN; 3WUSTL School of Medicine, St.
Louis, MO; 4Washington University, St. Louis, MO;
5
Howard Hughes Medical Institute, Evanston, IL
MOF am 10:10 pH-Dependent Changes in the Selectivity Filter
of KcsA Assessed by Radiolytic Footprinting and
Structural Mass Spectrometry; Rhijuta D’mello1;
Vassiliy N Bavro2; Sayan Gupta1; Mark R Chance1;
Stephen J Tucker2; 1Center for Proteomics and
Bioinformatics, CWRU, Cleveland, OH; 2Clarendon
Lab., Dept. of Physics, Univ. of Oxford, Oxford,UK
8:30 – 10:30 AM, MONDAY MORNING
FUNDAMENTALS OF PEPTIDE FRAGMENTATION
Kristina Hakansson (University of Michigan), presiding
Room 102
MOG am 08:30 Evidence of Third Residue Involvement in
Diketopiperazine and Oxazolone b2 Ion Formation
in NAXIG and QAXIG Pentapeptides; Lindsay
Morrison1; Julia Chamot-Rooke2; Vicki Wysocki1;
1
Ohio State University, Columbus, OH; 2Pasteur
Institute, Paris, France

61ST ASMS CONFERENCE ON MASS SPECTROMETRY						

PAGE 29

MONDAY
GENERAL
MORNING
INFORMATION
ORAL SESSIONS

MOG am 08:50 Regioselective18O-Labeling to Quantify
Competing H3PO4 versus HPO3+H2O Side Chain
Neutral Losses from Protonated Phosphopeptide
Ions during CID-MS/MS; Li Cui; Ipek Yapici; Babak
Borhan; Gavin Reid; Michigan State University, East
Lansing, MI
MOG am 09:10 In-source Decay during MALDI Combined with
Collisional Process in FTICR Mass Spectrometer;
Daiki Asakawa; David Calligaris; Edwin De Pauw;
University of Liège, Liege, Belgium
MOG am 09:30 Peptide Fragmentation Patterns as a Measure of
Antioxidant Capacity; Omar Hamdy; Ryan Julian;
UC-Riverside, Riverside, CA
MOG am 09:50 Gas-phase Fragment Ion Isomer Analysis Reveals
the Mechanism of Peptide Sequence Scrambling;
Chenxi Jia; Zhe Wu; Christopher Lietz; Zhidan Liang;
Qiang Cui; Lingjun Li; University of Wisconsin,
Madison, WI
MOG am 10:10 Electron Transfer Dissociation of
Conformationally Restricted Heptapeptides;
Robert Pepin; Alex Marek; Bo Peng; Frantisek
Turecek; U of Washington, Chemistry, Seattle, WA
8:30 – 10:30 AM, MONDAY MORNING
NUCLEIC ACIDS
Natalia Tretyakova (University of Minnesota), presiding
Room 103
MOH am 08:30 Structure/Dynamics Investigation of a Tertiary
Interaction in the HIV-1 Genome Packaging Signal
by Concerted MS and IMS-MS Approaches;
Jennifer Lippens; Maria Basanta-Sanchez; D. Fabris;
The RNA Institute, University at Albany, Albany, NY

MOH am 08:50 Targeted tRNA identification by Tandem Mass
Spectrometry; Collin Wetzel; Patrick Limbach;
University of Cincinnati, Cincinnati, OH
MOH am 09:10 Protein-RNA Interactions Identified in Megadalton
Ribonucleoprotein Complexes: the Human
Spliceosomal U1, U2, and U6/U4.U5 snRNPs;
Romina Hofele1; Katharina Kramer1; Florian
Richter2; Chung-Tien Lee1; Dmitry Agafonov1;
Reinhard Lührmann1; Henning Urlaub1, 3; 1MPI for
Biophysical Chemistry, Goettingen, Germany; 2MPI of
Inmunobiology and Epigenetics, Freiburg, Germany;
3
University Medical Center, Goettingen, Germany
MOH am 09:30 Characterization of Modified RNA by Top-Down
Mass Spectrometry; Monika Taucher; Kathrin
Breuker; University of Innsbruck, Innsbruck, Austria
MOH am 09:50 ESI-MS Study of a Cyclic Polyamide Selectively
Targeting the G-Quadruplex in c-myb Oncogene
Promoter; Xiaojie Cui; Han Chen; Qiang Zhang;
Jiang Zhou; Gu Yuan; College of Chemistry and
Molecular Engineering, Pe, Beijing, China
MOH am 10:10 Oxidation of the Methyl Group of Thymine and
5-Methylcytosine in DNA: Product Analyses
by LC-MS/MS and Mechanistic Studies; Guru
S Madugundu; J. Richard Wagner; Université de
Sherbrooke, Sherbrooke, Canada

10:30 AM - 2:30 PM
MONDAY POSTER SESSION
Exhibit Hall BC
Lunch concessions are open 11:00 am - 2:00 pm

MONDAY AFTERNOON ORAL SESSIONS
2:30 – 4:30 PM, MONDAY AFTERNOON
PTMs: COMPREHENSIVE ANALYSIS
Katalin Medzihradszky (UCSF), presiding
Exhibit Hall A (lower level)
MOA pm 2:30

MOA pm 2:50

MOA pm 3:10

Quantitative Proteomic and Phosphoproteomic
Analysis of iPS-Derived Cardiomyocytes
following Transfection with a miRNA Upregulated
In Heart Failure; Justin Blethrow1; Vlad Zabrouskov1;
Derek Lemons2; Mark Mercola2; Laurence Brill2;
1
Thermo Scientific, San Jose, CA; 2Sanford Burnham
Medical Research Institute, San Diego, CA
Expanding the Depth of Coverage in Quantitative
Phosphoproteomics through the Combination
of Metal Oxide and Motif-Specific Antibody
Enrichment Strategies; Erik J. Soderblom 1; J.
Will Thompson1; Charles L. Farnsworth2; Brenna M.
Richardson1; Jeffrey C. Silva2; M. Arthur Moseley1;
1
Duke University School of Medicine, Durham , NC;
2
Cell Signaling Technologies, Danvers, MA
Dynamic Phosphorylation Regulates Histone
Deacetylase Localization, Interactions, and Cell
Cycle-Dependent Functions; Amanda Guise;
Rommel Mathias; Todd Greco; Irene Zhang; Ileana
M. Cristea; Princeton University, Princeton, NJ

PAGE 30					

MOA pm 3:30

Quantitative Proteomics Reveals Important
Roles for Mitochondrial Acetylation in Metabolic
Transitions; Amelia J. Still; Brendan J. Floyd; Molly
Mcdevitt; Alex S. Hebert; Joshua J. Carson; Drew
R. Gunderson; Brendan K. Dolan; Paul A. Grimsrud;
Michael S. Westphall; David J. Pagliarini; Joshua J.
Coon; University of Wisconsin, Madison, WI

MOA pm 3:50

Quantification of Lysine Acetylation in
Escherichia coli Using Label-Free Proteomics:
Assessing the Role of Acetyl-CoA and AcetylPhosphate; Birgit Schilling1; Linda Hu2; Alexandria
K. D’Souza1; Misty L. Kuhn3; Dylan J. Sorensen1;
Bozena Zemaitaitis2; Bruno Lima2; Michael Scholle3;
Milan Mrksich3; Wayne F. Anderson3; Alan J. Wolfe2;
Bradford W. Gibson1; 1Buck Institute for Research
on Aging, Novato, CA; 2Loyola University Chicago,
Maywood, IL; 3Northwestern University, Chicago, IL

MOA pm 4:10

High-throughput Identification of Protein
Disulfide Bonds from Complex Samples; Shan
Lu1, 2; Bing Yang2; Sheng-Bo Fan3; Jia-Ming Meng3;
Long Wu3; Kun Zhang3; Mei-Jun Zhang2; En-Zhi
Shen2; Chun-Qing Song2; Yu-Xin Li2; Rui-Xiang
Sun3; Si-Min He3; Meng-Qiu Dong1, 2; 1College of Life
Science, Beijing Normal University, Beijing, China;
2
National Institute of Biological Sciences, Beijing,
Beijing, China; 3ICT, Chinese Academy of Sciences,
Beijing, China

61ST ASMS CONFERENCE ON MASS SPECTROMETRY

MONDAY AFTERNOON ORAL SESSIONS

2:30 – 4:30 PM,
MONDAY AFTERNOON

MOC pm 3:10

In-Paper Dried Blood Spot Enzyme Assays for
the Reliable Determination of Plasma Enzyme
Activities; Eszter Szabo1; Ildiko Szatmari2; Julia
Denes3; Laszlo Szonyi2; Zoltan Takats3; 1Eötvös
Lóránd University, Budapest, HUNGARY; 21st Dept.
of Pediatrics, Semmelweis University, Budapest,
Hungary; 3Imperial College London, London, UK

MOC pm 3:30

Application of LC-MS/MS to Determine the
Exposure to Methyl and Propyl Parabens in
Preterm Neonates using Dried Blood Spot (DBS);
Shirish Yakkundi1; James McElnay1; Mark Turner2;
1
Queen’s University Belfast, Belfast, UK; 2Liverpool
Women’s NHS Foundation Trust, Liverpool, UK

MOC pm 3:50

Detergent-Assisted Elution: Method Optimization
to Improve Analyte Elution and Assay
Performance for Dried Matrix Spots (DMS) by
uHPLC-MS/MS; Naiyu Zheng1; Jianing Zeng1; Qin C.
Ji1; Aida Angeles1; Shenita Basdeo1; Anne-Francoise
Aubry1; Ishani Savant2; Navin Jariwala2; Mark E.
Arnold1; 1Bioanalytical Sciences, Bristol-Myers
Squibb Co., Princeton, NJ; 2DMCP, Bristol-Myers
Squibb Co., Pennington, NJ

MOC pm 4:10

Sensitive Quantification of Insulin-like Growth
Factor-1and Its Synthetic Analogues in Dried
Blood Spots; Holly Cox; Daniel Eichner; Sports
Medicine Research and Testing Laboratory, Salt
Lake City, UT

TOP-DOWN AND MIDDLE-DOWN PROTEIN
ANALYSIS
HONORING FRED MCLAFFERTY’S 90TH
BIRTHDAY
Joseph Loo (UCLA), presiding
Room L100 (lower level)
MOB pm 2:30

Fragmenting Intact Macromolecules and Protein
Assemblies: Native ESI and Top-down MS
for Protein Biophysics and Analysis; Michael
L. Gross1; Hao Zhang1; Weidong Cui 1; Lisa M.
Jones2; Justin Sperry3; James A Carroll3; Robert E.
Blankenship1; Weikai Li1; 1Washington University,
St. Louis , MO; 2IUPUI, Indianapolis, IN; 3Pfizer,
Chesterfield, MO

MOB pm 2:50

Top-down Mass Spectrometry Enabled Cardiac
Proteomics for Understanding Heart Failure; Ying
Ge; University of Wisconsin, Madison, WI

MOB pm 3:10

Unequivocal Determination of Site-Specific
Protein Disulfide Bond Reduction Potentials by
Top-Down FT-ICR MS/MS; Alan G. Marshall; Jenna
Scotcher; Nicolas Young; Ion Cyclotron Resonance
Prog, Tallahassee, FL

MOB pm 3:30

Detailed Characterization of Complex Protein and
RNA Modification Patterns by Top-Down Mass
Spectrometry; Barbara Ganisl; Kathrin Breuker;
University of Innsbruck, Innsbruck, Austria

MOB pm 3:50

Antibody Characterization by Top-Down and
Middle-Down Electron Transfer Dissociation
using a High-Field Orbitrap FTMS; Luca Fornelli1;
Anton N. Kozhinov1; Ünige A. Laskay1; Daniel
Ayoub2; Alain Beck2; Yury O. Tsybin1; 1Ecole
Polytechnique Fédérale de Lausanne, Lausanne,
Switzerland; 2Centre d’Immunologie Pierre Fabre, St
Julien-en-Genevois, France

MOB pm 4:10

Comprehensive Top Down Proteomics of Human
Cells: The Role of Mitochondria and Membrane
Proteins in Cellular Senescence; Adam
Catherman; Kenneth Durbin; Owen Skinner; Dorothy
Ahlf; Bryan Early; Philip Compton; Paul Thomas; Neil
Kelleher; Northwestern University, Evanston, IL

2:30 – 4:30 PM, MONDAY AFTERNOON
CLINICAL CHEMISTRY, DRIED BLOOD SPOT ANALYSIS
Karen Phinney (NIST), presiding
Ballroom B
MOC pm 2:30

MOC pm 2:50

Multiplex Newborn Screening of Lysosomal
Storage Diseases using Flow Injection Tandem
Mass Spectrometry; Mariana Barcenas1; Martin
Sadilek1; Frantisek Turecek1; Michael Gelb1, 2;
Ronald Scott3; 1Department of Chemistry, University
of Washington, Seattle, WA; 2Department of
Biochemistry, University of Washington, Seattle, WA;
3
Department of Pediatrics, University of Washington,
Seattle, WA
HPLC-ESI-MS/MS Analysis of Hemoglobin
Peptides in Tryptic Digests of Dried-Blood Spot
Extracts Detects HbS, HbC, HbE, HbO-Arab
and HbG-Philadelphia Mutations; Christopher
A. Haynes1; Stephanie Guerra2; Victor De Jesus1;
1
Centers for Disease Control and Prevention, Atlanta,
GA; 2Harvard University, Cambridge, MA

2:30 – 4:30 PM, MONDAY AFTERNOON
BIOTHERAPEUTICS, IMPURITIES AND DEGRADANTS:
STRUCTURAL CHARACTERIZATION
Justin Sperry (Pfizer), presiding
Ballroom A
MOD pm 2:30

The Main Cause of Amino Acid Misincorporations
in Recombinant Proteins; Zhongqi Zhang;
Bhavana Shah; Pavel Bondarenko; Amgen, Inc.,
Thousand Oaks, CA

MOD pm 2:50

Rapid Characterization and Comparison of
Stressed anti-CD20 Drugs using Middle Down
Mass Spectrometry; Ashley Gucinski; Timothy Toby;
Michaella Levy; Bo Wang; Michael Boyne; U.S. FDA,
Division of Pharmaceutical Analysis, Saint Louis, MO

MOD pm 3:10

Assessing the Impact of Chemical Modifications
on mAb Conformational Dynamics using
Hydrogen/Deuterium Exchange Mass
Spectrometry (HDX-MS); Aming Zhang; Paul
MacGregor; Yu Xue; Aston Liu; Leonard Olszewski;
Ping Hu; GlaxoSmithKline, King of Prussia, PA

MOD pm 3:30

Characterization of Non-Native, Intermolecular
Disulfide Linkages in a Recombinant Protein by
LC-MS/MS; Chris Morgan; Xiaoying Jin; X. Kate
Zhang; Genzyme, A Sanofi Company, Framingham,
MA

MOD pm 3:50

Comprehensive Comparison of Biosimilar
Protein Drugs by High-Separation and HighResolution LC-MS; David Horn1; Shiaw-Lin Wu2;
Zhiqi Hao1; 1Thermo Fisher Scientific, San Jose, CA;
2
Barnett Institute, Northeastern University, Boston,
MA

MOD pm 4:10

One-Dimensional Liquid Chromatography
Analysis of Host Cell Proteins in Therapeutic
Antibodies using an Orbitrap Velos; Ashley Bell;
Richard Rogers; Tom Kowski; Bailey Robert; Amgen,
Seattle, WA

61ST ASMS CONFERENCE ON MASS SPECTROMETRY						

PAGE 31

MONDAYGENERAL
AFTERNOON
INFORMATION
ORAL SESSIONS

2:30 – 4:30 PM, MONDAY AFTERNOON
HIGH MASS ACCURACY IN DRUG DISCOVERY AND
DEVELOPEMENT
Karin Keller (Cleveland HeartLab), presiding
Auditorium
MOE pm 2:30 Rapid Antibody de novo Sequencing by
Reference Sequence Matching; Bianca Gruenwalder;
Stefan Klostermann; Maximiliane Hilger; Roche
Diagnostics GmbH, pRED, Penzberg , Germany
MOE pm 2:50 Evaluation of LC-HRMS Full Scan with PositiveNegative Switching for Increasing Throughput
of Human In Vitro Cocktail Drug-Drug Interaction
Assay; Ragu Ramanathan1; Brad Yuska1; Kate
Comstock2; Lakshmi Ramanathan1; Tim Stratton2;
Patrick Bennett2; Helen Shen1; Zamas Lam1; 1QPS,
LLC, Newark, DE; 2ThermoFisher, San Jose, CA
MOE pm 3:10 From MS Data to Information and from
Information to Knowledge; Ismael Zamora1;
Andreas Brink2; Eickhoff Kirsten 2; Cece Esra
Nurten3; Axel Paehler2; 1Lead Molecular Design,
S.L., Sant Cugat Del Valles, SPAIN; 2F. HoffmannLa Roche Ltd, Basel, Switzerland; 3Pompeu Fabra
University, Barcelona, Spain
MOE pm 3:30 Combing Sub-PPM Mass Accuracy and Isotopic
Fine Structures for Structural Elucidation in
Pharmaceutical Drug Development; Guilong
(Charles) Cheng; Ron Morris; Victor Soliman; Pfizer,
Inc., Groton , CT
MOE pm 3:50 Comparative Analysis of Pharmaceutical
Excipients using High Performance Time fo
Flight Mass Spectrometry – Purity Evaluaton and
Impurity Identification; Jeffrey Patrick; Joe Binkley;
Stephanie Amaya; Kevin Siek; LECO Corporation,
St. Joseph, MI
MOE pm 4:10 Quality Control for Shuxuetong Injection by High
Resolution Mass Spectrometry Based Statistical
Analysis; Zheng-Xiang Zhang; Tao Bo; Wei Chen;
Zhi-Xu Zhang; Agilent Technologies, Beijing, China
2:30 – 4:30 PM, MONDAY AFTERNOON
PROTEIN- PROTEIN AND PROTEIN-LIGAND INTERACTIONS
David Russell (Texas A&M University), presiding
Room 101
MOF pm 2:30 Dissecting Large Non-covalent Ring Protein
Complexes by Surface Induced Dissociation
Combined with Ion Mobility; Mowei Zhou; Yun
Zhang; Vicki Wysocki; Ohio State University,
Columbus, OH
MOF pm 2:50 Probing the Limits of Mass Spectrometry in
Analyzing Mega Dalton Assemblies; Joost
Snijder1; Rebecca J. Rose1; David Veesler2; John
E. Johnson2; Albert J.R. Heck1; 1Utrecht University,
Utrecht, The Netherlands; 2The Scripps Research
Institute, La Jolla, CA
MOF pm 3:10 Time Window Expansion for HDX Analysis of an
Intrinsically Disordered Protein; Patrick Griffin1;
Devrishi Goswami1; Srikripa Devarakonda2; Michael
Chalmers1; Bruce Pascal1; Bruce Spiegelman2; 1The
Scripps Research Institute, Jupiter, FL; 2Harvard
Medical School, Dana-Farber Cancer INST, Boston, MA
MOF pm 3:30 Proteomic Mapping of Mitochondria in Living
Cells via Spatially-Restricted Enzymatic Tagging;
Hyun-Woo Rhee1; Peng Zou1; Namrata Udeshi2;
Jeffrey Martell1; Tanya Svinkina2; Vamsi Mootha2, 3;
Steven Carr2; Alice Ting1, 2; 1Massachusetts Institute
of Technology, Cambridge, MA; 2The Broad Institute
of MIT and Harvard, Cambridge, MA; 3Harvard
Medical School, Boston, MA

PAGE 32					

MOF pm 3:50

Utilization of Epitope-Tagged Knock-in Mice
for IP-MS/MS Analysis of the Effects of Drug
Treatments on the Dopamine Transporter
Interactome; Sarah Rogstad1, 2; John Caltagarone1;
Shiqi Ma1; Alexander Sorkin1; Christine Wu1;
1
University of Pittsburgh, Pittsburgh, PA; 2University
of Colorado, Anschutz Medical Campus, Aurora, CO

MOF pm 4:10

Monitoring the Pathways of Fibril Formation
and Inhibition from the Amyloidogenic Protein
IAPP using ESI-IMS-MS; Lydia Young; Sheena E
Radford; Alison E. Ashcroft; Faculty of Biological
Sciences,University of Leeds, Leeds, UK

2:30 – 4:30 PM, MONDAY AFTERNOON
FUNDAMENTALS OF ION ACTIVATION AND DISSOCIATION
Eric Dodds (University of Nebraska-Lincoln), presiding
Room 102
MOG pm 2:30 Charge Reversal Fourier Transform Ion
Cyclotron Resonance Mass Spectrometry;
Vladislav Lobodin1, 2; Joshua Savory1; Nathan
Kaiser1; Ryan Rodgers1, 2; Alan Marshall1, 3; 1National
High Magnetic Field Laboratory, Tallahassee, FL;
2
Future Fuels Institute, Tallahassee, FL; 3Florida
State University, Tallahassee, FL
MOG pm 2:50 Factors that Influence Competitive
Intermolecular Solvation of Protonated Groups in
Peptides and Proteins in the Gas Phase; Yuanqi
Tao; Ryan Julian; UC Riverside, Riverside, CA
MOG pm 3:10 Systematic niECD Mechanistic Exploration with
Synthetic Peptides and Fixed-Charge Tags; Ning
Wang; Kristina Hakansson; University of Michigan,
Ann Arbor, Michigan
MOG pm 3:30 Using Dissociation Energies to Predict
Observability of b- and y- Peaks in Mass Spectra
of Tryptic Hexapeptides; Oleg Obolensky 1; Wells
Wu2; Rong-Fong Shen2; Yi-Kuo Yu1; 1National Center
for Biotechnology Information, NLM, Bethesda , MD;
2
Center for Biologics Evaluation and Research, FDA,
Bethesda, MD
MOG pm 3:50 Elucidation of Heterolytic N-Cα Bond Cleavage
in ECD/ETD Mass Spectrometry; Matthew
D. Wodrich; Konstantin O. Zhurov; Clémence
Corminboeuf; Yury O. Tsybin; Ecole Polytechnique
Fédérale de Lausanne, 1015 Lausanne, Switzerland
MOG pm 4:10 Development of a Detailed Molecular Model for
the Collision Induced Unfolding of MultiproteinLigand Complexes; Shuai Niu; Brandon Ruotolo;
University of Michigan, Ann Arbor, MI
2:30 – 4:30 PM, MONDAY AFTERNOON
PHOTOIONIZATION
Jack Syage (Syagen/Morpho Detection), presiding
Room 103
MOH pm 2:30 Gas Chromatography – Atmospheric Pressure
Photoionization – Tandem Mass Spectrometry
(GC-APPI-MS/MS) in Neurosteroid Analysis; Tina
Suominen1; Markus Haapala1; Anna Takala1; Raimo
A Ketola2; Risto Kostiainen1; 1University of Helsinki,
Helsinki, Finland; 2Hjelt Institute, Helsinki, Finland
MOH pm 2:50 Studying the Effects of Simulated Solar
Radiation upon Crude Oil using Fourier
Transform Ion Cyclotron Resonance Mass
Spectrometry; Matthew Griffiths; Raffaello da
Campo; Peter O’Connor; Mark Barrow; University of
Warwick, Coventry, UK

61ST ASMS CONFERENCE ON MASS SPECTROMETRY

MONDAY AFTERNOON ORAL SESSIONS

MOH pm 3:10

MOH pm 3:30

MOH pm 3:50

MOH pm 4:10

A New APPI Ion Source for Low Flow LCMS and CE-MS Analysis of Small Molecules;
Sheng-Suan (Victor) Cai 1; Andy Gieschen2; Martin
Greiner3; Brian Nies1; Stefan Lukow1; Michael
Patterson1; 1Morpho Detection, Inc., Santa Ana, CA;
2
Agilent Technologies, Inc., La Jolla, CA; 3Agilent
Technologies, Waldbronn, Germany
GC and the Exactive Orbitrap – Two Approaches
for Powerful GC APPI Interfaces; Hendrik Kersten;
Kai Kroll; Thorsten Benter; University of Wuppertal,
Wuppertal , Germany
Fast Switchable Photon/Electron Ionization
for Time–of–Flight Mass Spectrometry and Its
Application for Gas Chromatography – Mass
Spectrometry; Thomas Groeger1, 2; Mohammad
Reza Saraji-Bozorgzad2; Ralf Zimmermann3; 1Joint
Mass Spectrometry Centre, Oberschleissheim,
Germany; 2Photonion GmbH, Schwerin, Germany;
3
University of Rostock, Rostock, Germany
Thermal Analysis--Single Photon Ionization
Mass Spectrometry for Highly Resolved
Thermo-Chemical Evolved Gas Speciation:
Coffee Roasting and Crude Oil Characterization;
Mohammad Reza Saraji-Bozorgzad; Andreas Walte;
Thomas Groeger; Matthias Bente-von Frowein;
Photonion GmbH, Neuherberg, Germany

4:45 - 5:30 PM, MONDAY
AWARD LECTURE
Susan T. Weintraub (Univ of Texas HSC-San Antonio), presiding
Exhibit Hall A, Lower Level
Award for a Distinguished Contribution in
Mass Spectrometry
Richard D. Smith
Pacific Northwest National Laboratory

5:45 - 7:00 PM, MONDAY AFTERNOON
WORKSHOPS
Light snacks are provided on level two.
•

•

•

•

•

•

•
•

•
•
•

Level One Rooms
The Informatical Difference between Targeted and
Discovery-based Proteomics (organized by the Bioinformatics
for MS Interest Group), Room 1
Have Recent LC-MS Techniques Advanced to Substitute
AMS in Analyzing Microdose and other Low Level Clinical
Studies for Metabolites and Drug Related Material?
(organized by the DMPK Interest Group), Room 2
Trans-Proteomic Pipeline (TPP) and Related Open-Source
Proteomics Resources, Room 3
Level Two Rooms
FRAGILE Modifications, Handle with Care during Peptide
Fragmentation (organized by the Peptide Fragmentation Interest
Group), Room 200 DE
Mass Spectrometry-based Characterization of
Biotherapeutics (organized by the Protein Therapeutics
Interest Group), Room 200 FG
How Can MS Analysis Be Used to Improve Analytical
Results and Laboratory Efficiency (organized by the Flavor,
Fragrance and Foodstuff Interest Group), Room 200 H
Nucleic Acids as Diagnostic and Therapeutic Biomarkers
(organized by the DNA/RNA Interest Group), Room 200 I
Surviving and Thriving: A Panel Discussion for Both
Students and PUI Faculty on How to Get the Most out of
Undergraduate Research (organized by the Undergraduate
Research in MS interest Group), Room 205 AB
Photonization Mass Spectrometry, Room 205 CD
Consortium for Top Down Proteomics, Room 208 AB
Data Independent Acquisition, Room 208 CD

AFTER 8:00 PM
CORPORATE HOSPITALITY SUITES
HILTON MINNEAPOLIS HOTEL

TUESDAY MORNING ORAL SESSIONS
8:30 – 10:30 AM, TUESDAY MORNING
QUANTITATIVE PROTEOMICS
David Muddiman (North Carolina State Univ), presiding
Exhibit Hall A (lower level)
TOA am 08:30 18-plex SILAC, and there’s room to grow;
Christopher M. Rose1; Alexander S. Hebert1; Anna
E. Merrill1; Derek J. Bailey1; Joel C. Bradley2; William
W. Wood2; Marwan Elmasri2; Michael S. Westphall1;
Joshua J. Coon1; 1University of Wisconsin, Madison,
WI; 2Cambridge Isotope Laboratories, Andover, MA
TOA am 08:50 Highly Sensitive Proteomic Analysis of AgeRelated Protein Aggregation; Dirk M. Walther;
Franz-Ulrich Hartl; Matthias Mann; MPI of
Biochemistry, Martinsried, Germany
TOA am 09:10 Quantitative Proteomic Analysis of Reversible
Cysteine Oxidation in Hearts from Mice Fed a
Western Diet; Jessica B Behring; Vikas Kumar;
Pratibha Chauhan; Stephen A Whelan; Deborah
A Siwik; Catherine E Costello; Wilson S Colucci;
Richard A Cohen; Mark E McComb; Markus M
Bachschmid; Boston University School of Medicine,
Boston, Ma

TOA am 09:30 Increasing the Breadth and Depth of Multi-Notch
MS3-based TMT Quantitation using a Hybrid
Q-OT-qIT Mass Spectrometer; Graeme McAlister1;
Edward Huttlin1; Mark P. Jedrychowski1; Martin
Wuehr1; Ramin Rad1; David Nusinow1; Philip Remes2;
Jesse Canterbury2; Vlad Zabruouskov2; Justin
Blethrow2; Shannon Eliuk2; Mike Senko2; Wilhelm
Haas1; Steven P. Gygi1; 1Harvard Medical School,
Boston, MA; 2Thermo Fisher Scientific, San Jose, CA
TOA am 09:50 Peptide Barcodes: A Genetic Approach for
N-Plexing Protein Quantification for Synthetic
Biology Applications; Pragya Singh1, 2; Becky J.
Rutherford1, 2; Vikram R. Ramakrishnan3; Paul D.
Adams1, 2; Jay D. Keasling1, 2; Christopher J. Petzold1,
2 1
; Lawrence Berkeley National Lab, Berkeley, CA;
2
Joint BioEnergy Institute, Emeryville, CA; 3University
of California, Berkeley, CA
TOA am 10:10 Highly Multiplexed and Sensitive Quantitation of
Candidate Disease-related Biomarker Proteins
in Human Plasma by 1-D and 2-D LC/MRM-MS;
Andrew Percy1; Andrew Chambers1; Juncong Yang1;
Martin Eisinger1; Christoph Borchers1, 2; 1University
of Victoria-Genome BC Proteomics Centre, Victoria,
Canada; 2Dept of Biochemistry and Microbiology, U
Victoria, Victoria, Canada

61ST ASMS CONFERENCE ON MASS SPECTROMETRY						

PAGE 33

TUESDAY
MORNING
ORAL SESSIONS
GENERAL
INFORMATION

8:30 – 10:30 AM, TUESDAY MORNING
IMAGING MS: INCREASING SPEED AND
INFORMATION CONTENT
Kevin Schey (Vanderbilt University), presiding
Room L100 (lower level)
TOB am 08:30 High Speed AP-MALDI Imaging at High Spatial
Resolution; Bernhard Spengler1; Andreas Römpp1;
Karl-Christian Schäfer1; Sabine Guenther1; Oliver
Schulz1; Alfons Hester1; Christian Schinz1; Christian
Lotze1; Jörg-Ulrich Pötzl1; Oliver Lange2; Kerstin
Strupat2; 1Justus Liebig University, Giessen, Germany;
2
Thermo Fisher Scientific GmbH, Bermen, Germany
TOB am 08:50 High-Speed Imaging using Nanospray
Desorption Electrospray Ionization Mass
Spectrometry: Toward 3D and MS/MS Imaging;
Julia Laskin1; Ingela Lanekoff1; Mathew Thomas1;
James Carson1; Kristin Burnum1; Jeeyeon Cha2;
Sudhansu K Dey2; Mari Prieto3; Pengxiang Yang3;
1
Pacific NW National Laboratory, Richland, WA;
2
Cincinnati Childrens’s Hospital Medical Center,
Cincinnati, OH; 3Thermo Fisher Scientific, San Jose, CA
TOB am 09:10 Mass Spectrometry Imaging with a LAESI Hybrid
Iontrap FT-ICR Mass Spectrometer; Andras Kiss1;
Donald F. Smith1; Brent R. Reschke2; Matthew J.
Powell2; Ron M.A. Heeren1; 1FOM Institute AMOLF,
Amsterdam, Netherlands; 2Protea Biosciences, Inc.,
Morgantown, WV
TOB am 09:30 Ambient Molecular Imaging and Quantitative
Analysis by Laser Ablation Electrospray
Ionization Mass Spectrometry with Ion Mobility
Separation; Hang Li1; Brian K. Smith1; Peter
Nemes2; Akos Vertes1; 1The George Washington
University, Washington, DC; 2Food and Drug
Administration, Silver Spring, MD
TOB am 09:50 Polarity Switching Multiplex MALDI Imaging on
an LTQ-Orbitrap Hybrid Mass Spectrometer;
Andrew Korte1, 2; Young-Jin Lee1, 2; 1Iowa State
University, Ames, IA; 2Ames Laboratory/USDOE,
Ames, IA
TOB am 10:10 Visualizing Biomolecular Modifications in Tissue:
Integrating Mass Difference (Δ-m/z) Scanning
Algorithms and MALDI FT-ICR Imaging Mass
Spectrometry; Jeffrey Spraggins; Raf Van de
Plas; Kerri Grove; David Rizzo; Richard Caprioli;
Vanderbilt University, Nashville, TN
8:30 – 10:30 AM, TUESDAY MORNING
FUNCTIONAL FOODS, PHYTOCHEMICALS, AND SUPPLEMENTS
Nadja Cech (Univ of North Carolina-Greensboro), presiding
Ballroom B
TOC am 08:30 Analysis of an Adulterated Herbal Medicinal
Product using UPLC-Qtof-MS; Mark Powell1;
Margaret Maziarz2; Michael D. Jones2; Warren
Potts2; Kate Yu2; 1Quay Pharmaceuticals, Flintshire,
UK; 2Waters Corporation, Milford, MA
TOC am 08:50 Screening Herbal Supplements using Statistical
Modeling to Find and Identify Adulterants and
Contaminants using Direct Analysis in Real
Time (DART)-MS; Nick Levitt1; Joseph LaPointe2;
Michael Festa2; Elizabeth Crawford2; 1TwoCenter
Technologies, Cambridge, MA; 2IonSense Inc.,
Saugus, MA

PAGE 34					

TOC am 09:10 Solvent- and Gas-Phase Deuteration of
Polyphenolics Informs their Identification by
Mass Spectrometry; Mikel R Roe; Jerry Cohen;
Adrian Hegeman; University of MN, St. Paul, MN
TOC am 09:30 Human Pharmacokinetics of Xanthohumol,
a Flavonoid with Anti-Diabetic Activity
Derived from Hops; LeeCole Legette1; Chanida
Karnpracha1; Ralph Reed1; Jaewoo Choi1; J. Mark
Christensen1; Jonathan Purnell2; J.Fred Stevens1;
1
Oregon State University, Corvallis, OR; 2Oregon
Health Sciences University, Portland, OR
TOC am 09:50 How Can Mass Spectrometry Help to Decipher
Bioactive Peptides in Functional Food? Michael
Affolter; Alexandre Panchaud; Nestle Research
Centre, Lausanne, Switzerland
TOC am 10:10 EnzymePredictor: A Tool for Predicting and
Visualizing Enzymatic Cleavages of Digested
Proteins; Nora Khaldi1, 2; Vaishnavi Vijayakumar1;
Andreś Guerrero2; Norman Davey3; Carlito Lebrilla2;
Denis Shields1; 1University College Dublin, Dublin,
Ireland; 2University College Davis, CA; 3European
Molecular Biology Laboratory, Heidelberg, Germany
8:30 – 10:30 AM, TUESDAY MORNING
PTMs: GLYCOSYLATION
Heather Desaire (University of Kansas), presiding
Ballroom A
TOD am 08:30 Development of a Fully Characterized N-Glycan
Library from Human Serum with Structures
and Relative Abundances; Ting Song; Danielle
Aldredge; Javier González; Carlito Lebrilla;
University of California, Davis, CA
TOD am 08:50 Applications of Aldehyde-Reactive Thermo
Scientific Tandem Mass Tag (TMT) Reagents
for Mass Spectrometry-based Quantitative
Glycomics; Sergei Snovida1; Karsten Kuhn2; John
C. Rogers1; 1ThermoFisher Scientific, Rockford, IL;
2
Proteome Sciences, Frankfurt, Germany
TOD am 09:10 Increasing the Accessibility of N-Glycopeptide
Determination via an Integrated Informatics and
Instrumental Strategy; John Froehlich1, 2; Oliver
Serang1, 2; Peter Warren1; Hui Zhou1, 2; Judith Steen1,
2
; Richard Lee1, 2; 1Boston Children’s Hospital,
Boston, MA; 2Harvard Medical School, Boston, MA
TOD am 09:30 The Occurrence of Extracellular O-glycosylation
in Murine Synaptosomes; Katalin F.
Medzihradszky1; Jonathan C. Trinidad1, 2; Ralf
Schoepfer3; Al Burlingame1; 1UCSF, San Francisco,
CA; 2Department of Chemistry, Indiana University,
Bloomington, IN; 3Department of Pharmacology,
UCL, London, UK
TOD am 09:50 Glycoproteomic Analysis of Mycobacterium
Tuberculosis Culture Filtrate Proteins using
Multiple Fragmentation Techniques; Geoffrey T.
Smith; Michael J Sweredoski; Sonja Hess; Caltech,
Pasadena, CA
TOD am 10:10 Comparative Glycoproteomics Analysis of
Influenza Hemagglutinin (H5N1) Expressed in
Vaccine and Vaccine Research Relevant Cell
Substrates; Yanming An; John Cipollo; FDA,
Bethesda, MD

61ST ASMS CONFERENCE ON MASS SPECTROMETRY

TUESDAY MORNING ORAL SESSIONS

8:30 – 10:30 AM, TUESDAY MORNING
SYSTEMS BIOLOGY/CELLULAR PATHWAYS
Ileana Cristea (Princeton University), presiding
Auditorium
TOE am 08:30 Exploring Communication in the Tumor
Microenvironment; Catherine Fenselau 1; Meghan
Burke1; Waeowalee Choksawangkarn1; Rebecca
Rose1; Avantika Dhabaria1; Nathan Edwards2;
Suzanne Ostrand-Rosenberg3; 1University of
Maryland, College Park, MD; 2Georgetown University
Medical Center, washington , DC; 3UMBC, Baltimore,
MD
TOE am 08:50 Global Quantitative Phosphoproteomic Analysis
of RSK-Dependent Signal Transduction;
Jacob A. Galan1; Kathryn M. Geraghty2; Evgeny
Kanshin1; Joseph Tcherkezian1; Geneviève Lavoie1;
Benjamin E. Turk3; Bryan A. Ballif4; John Blenis2;
Pierre Thibault1, 5; Philippe P. Roux1, 5; 1Institute for
Research in Immunology and Cancer, Montreal,
Canada; 2Harvard Medical School, Boston, MA;
3
Yale University School of Medicine, New Haven, CT;
4
University of Vermont, Burlington, VT; 5Université de
Montréal, Montréal, Canada
TOE am 09:10 Key Contribution of Post-Transcriptional
Mechanisms to Circadian Metabolism Regulation
Revealed by Perseus Analysis of Quantitative
Proteomics and Cross-Omics Data; Juergen Cox;
Maria S Robles; Matthias Mann; Max-Planck-Institute
of Biochemistry, Martinsried, Germany
TOE am 09:30 Acetylome Machinery Interactome Revealed
by Data Dependent and Independent Mass
Spectrometry Acquisition; Jean-Philippe
Lambert1; Sarah Picaud2; Brett Larsen1; Beatriz
Gonzalez Badillo1; Tony Pawson1, 3; Stefan Knapp2;
Panagis Filippakopoulos2; Anne-Claude Gingras1,
3 1
; Samuel Lunenfeld Research Institute, Mount
Sinai H, Toronto, Canada; 2Nuffield Department of
Clinical Medicine, SGC, Oxford, UK; 3Department of
Molecular Genetics, U Toronto, Toronto, Canada
TOE am 09:50 Quantitative Dynamics of the Link between
Cellular Metabolism and Histone Acetylation;
Adam Evertts1; Barry Zee2; Peter DiMaggio3; Michelle
Cope2; Hilary Coller1; Benjamin Garcia2; 1Princeton
University, Princeton, NJ; 2University of Pennsylvania
School of Medicine, Philadelphia, PA; 3Imperial
College London, London, UK
TOE am 10:10 Multi-notch MS3-based 8-Plex TMT Quantification
of 8 Colorectal Cancer Cell Line Proteomes
Reveals Functional Reflections of Tumor
Mutation Profiles; David P. Nusinow; Graeme
McAlister; Edward L. Huttlin; Mark Jedrychowski;
Wilhelm Haas; Steven P. Gygi; Harvard Medical
School, Boston, MA
8:30 – 10:30 AM, TUESDAY MORNING
METABOLOMICS/LIPIDOMICS:
NEW MS TECHNOLOGIES AND APPLICATIONS
Mark Emmett (UTMB), presiding
Room 101
TOF am 08:30 Metabolomics: A Review of Issues Affecting
Translational Research; Paul Wood; Lincoln
Memorial University, Harrogate, TN
TOF am 08:50 Identification of Unknown Metabolites Involved
in Type 2 Diabetes with Accurate Mass GCQTOF Mass Spectrometry; John Meissen1; Kohei
Takeuchi2; Oliver Fiehn1; 1UC Davis, Davis, CA; 2Kao
Corporation, Tokyo, Japan

TOF am 09:10 Comprehensive Pathway-Specific Metabolite
Analysis of Central Carbon Metabolism using
Three Complementary LC/ESI-MS Methods; Jun
Han1; Adrien Nyakas1; Tobias Eckle2; Christoph
Borchers1, 3; 1University of Victoria-Genome BC
Proteomics Centre, Victoria, Canada; 2Department
of Anesthesiology, U Colorado, Denver, CO; 3Dept of
Biochemistry and Microbiology, U Victoria, Victoria,
Canada
TOF am 09:30 Multi-Omics Profiling of Methionine-Restricted
MCF7 Cells in 24 Hours using a Prototype UPLCCompatible Microfluidic Device; J. Will Thompson
1
; Jay Johnson2; Giuseppe Astarita2; Xiaohu
Tang1; Giuseppe Paglia3; Jim Murphy2; Steven
Cohen2; Mark Bennett4; Jen-Tsan Chi1; James
Langdridge2; Geoff Gerhardt2; M. Arthur Moseley1;
1
Duke University School of Medicine, Durham ,
NC; 2Waters Corporation, Milford, MA; 3Center for
Systems Biology, Univ of Iceland, Reykjavik, Iceland;
4
Nonlinear Dynamics, Durham, NC
TOF am 09:50 Identification of Nuclear Lipids; Huan He1; Nicolas
L. Young1; Alan G. Marshall1, 2; 1Ion Cyclotron
Resonance Program, NHMFL, Tallahassee, FL;
2
Department of Chemistry and Biochemistry, FSU,
Tallahassee, FL
TOF am 10:10 The Use of Ion-Mobility Mass Spectrometry for
Separation and Structural Elucidation of Lipids
in Human Plasma. Application in Lipidomics
Studies; Carola W.N. Damen1, 2; Giorgis Isaac3;
Jonathan P. Williams4; Johannes P.C. Vissers4;
James I. Langridge4; Thomas Hankemeier1, 2; Rob
J. Vreeken1, 2; 1Netherlands Metabolomics Centre,
Leiden University, Leiden, The Netherlands;
2
Analytical Biosciences, LACDR, Leiden University,
Leiden, The Netherlands; 3Waters Corporation,
Milford, MA, Waters Corporation., Manchester, UK
8:30 – 10:30 AM, TUESDAY MORNING
ION MOBILITY: SEPARATIONS
John McLean (Vanderbilt University), presiding
Room 102
TOG am 08:30 An Efficient Approach for Flexible Ion Transport,
Mobility Separation, and Reaction; Richard D.
Smith; Xinyu Zhang; Erin Baker; Yehia Ibrahim;
Gordon Anderson; Keqi Tang; PNNL, Richland, WA
TOG am 08:50 Characterization of a New Uniform-Field Ion
Mobility-Quadrupole Time-of-Flight Mass
Spectrometer and its Application in Biomolecular
Analyses; Ruwan Kurulugama; Alexander Mordehai;
Nathan Sanders; Ed Darland; Christian Klein; Crystal
Cody; Bill Barry; George Stafford; John Fjeldsted;
Agilent Technologies, Santa Clara, CA
TOG am 09:10 Toward Calibration Standards for Ion Mobility
Spectrometry (IMS); William F. Siems1; Larry
A. Viehland2; Herbert H. Hill1; 1Washington State
University, Pullman, WA; 2Chatham University,
Pittsburgh, PA
TOG am 09:30 Stereoisomers Separation by Ion Mobility-Mass
Spectrometry; Virginie Domalain1; Marie HubertRoux1; Catherine Lange1; Vincent Tognetti1; Jacques
Rouden2; Carlos Afonso1; 1Normandie Univ UMR
6014, FR 3038; Univ Rouen; CNRS, Mont St Aignan,
France; 2Normandie Univ UMR 6507, FR 3038;
ENSICAEN; CNRS, Caen, France

61ST ASMS CONFERENCE ON MASS SPECTROMETRY						

PAGE 35

TUESDAY
MORNING
ORAL SESSIONS
GENERAL
INFORMATION

TOG am 09:50 Petroleomics by TWIM-MS: Development,
Optimization and Applications of a Powerful
Analytical Tool for Crude Oil and Petrofuel
Characterization; Maíra Fasciotti1, 2; Clécio F.
Klitzke2; Priscila M. Lalli2, 3; Yuri E. Corilo3; Renan
S. Galaverna2; Marcos A. Pudenzi2; Heliara L.
Nascimento2; Ramsés Capilla4; Wagner Bastos4;
Erica Morais4; Romeu J. Daroda1; Rosana Pereira4;
Marcos N. Eberlin2; 1inmetro, Duque De Caxias,
Brazil; 2University of Campinas, Campinas,
Brazil; 3National High Magnetic Field Laboratory,
Tallahassee, FL; 4petrobras, Rio de Janeiro, Brazil
TOG am 10:10 Exploiting IM-MS Separation to Overcome
Heterogeneity in Protein Self Assembly; Justin
Benesch; University of Oxford, Oxford, UK
8:30 – 10:30 AM, TUESDAY MORNING
ANTIBODIES AND ANTIBODY-DRUG CONJUGATES
Yury Tsybin (Ecole Polytechnique Federale), presiding
Room 103
TOH am 08:30 An Integrated Top-Down and Bottom-Up
Proteomic Approach to Characterize Antibodies;
Lennard Dekker1; Si Wu2; Martijn Vanduijn1; Nikola
Tolić2; Christoph Stingl1; Rui Zhao2; Theo Luider1;
Ljiljana Paša-Tolić2; 1Erasmus Medical Center,
Rotterdam, Netherlands; 2Pacific Northwest National
Laboratories, Richland, WA
TOH am 08:50 In-Depth Mass Spectrometry Characterization of
Therapeutic Antibodies for Efficient Biosimilar
Development; Wolfgang Jabs1; Anja Resemann1;
Waltraud Evers1; Catherine Evans2; Laura Main3;
Carsten Baessmann1; Detlev Suckau1; Daniel
Ayoub4; Elsa Wagner-Rousset4; Alain Beck4;
1
Bruker Daltonik GmbH, Bremen, Germany; 2Bruker
Daltonics GmbH, Fällanden, Switzerland; 3Bruker
Daltonics Ltd, Coventry, UK; 4Centre d’Immunologie
Pierre Fabre, St Julien-en-Genevois, France

TOH am 09:10 Rapid Qualitative and Quantitative
Characterization of Antibody Glycosylation
Profiles by Native Mass Spectrometry using an
Orbitrap Mass Analyzer; Sara Rosati1; Ewald T.J.
van den Bremer2; Paul Parren2; Janine Schuurman2;
Albert J. R. Heck1; 1Utrecht University, Utrecht,
Netherlands; 2Genmab, Utrecht, Netherlands
TOH am 09:30 An Online Top-Down Mass Spectrometry Based
Strategy Aimed at Complete de novo Sequencing
of Monoclonal Antibodies; Weihan Wang1; A.
Michelle English1; Lissa Anderson1; John Syka2;
Sushma Shivaswamy3; Kevin Sunley3; John Simard3;
Jeffrey Shabanowitz1; Dina Bai1; Donald Hunt1, 4;
1
Department of Chemistry, University of Virginia,
Charlottesville, VA; 2Thermo Fisher Sci, San Jose,
CA; 3XBiotech USA Inc., Austin, TX; 4Department of
Pathology, University of Virginia, Charlottesville, VA
TOH am 09:50 Micro-Scale Native Top-Down LCMS of CysteineLinked Antibody-Drug Conjugates; Shawna M.
Hengel; Russell Sanderson; William McFee; Jay
Jones; John Valliere-Douglass; Stephen C. Alley;
Seattle Genetics, Bothell, WA
TOH am 10:10 New Technology for Producing Large
Repertoires of Bacterially Expressed HighAffinity Antibodies; Yinyin Li1; Peter C. Fridy1;
Mary K. Thompson1; Sarah Keegan2; David Fenyo2;
Michael P. Rout1; Brian T. Chait1; 1The Rockefeller
University, New York, NY; 2New York University, New
York, NY

10:30 AM - 2:30 PM
TUESDAY POSTER SESSION
Exhibit Hall BC
Lunch concessions are open 11:00 am - 2:00 pm

TUESDAY AFTERNOON ORAL SESSIONS
2:30 – 4:30 PM, TUESDAY AFTERNOON
INSTRUMENTATION AND METHODS: FT, ION TRAPS AND
HYBRID INSTRUMENTS
Jim Bruce (University of Washington), presiding
Exhibit Hall A (lower level)
TOA pm 2:30

TOA pm 2:50

TOA pm 3:10

Improving Data Dependent MSn Performance
with a Multitasking Mass Spectrometer; Michael
W. Senko1; Philip Remes1; Qingyu Song1; Jesse
Canterbury1; Justin Blethrow1; Vlad Zabrouskov1;
Oliver Lange2; Alexander Makarov2; 1Thermo Fisher
Scientific, San Jose, CA; 2Thermo Fisher Scientific
GmbH, Bremen, Germany
Development of a Mass Spectrometer for Gas
Phase Ion-Radical Reactions; Ziqing Lin1; Tsungchi
Chen1; Linfan Li1; Yu Xia2; Zheng Ouyang1; 1BME,
Purdue University, West Lafayette, IN; 2Chemistry,
Purdue University, West Lafayette, IN
2D FT-ICR Optimized Pulse Sequence:
Application to Human Plasma Triglyacylglycerols
(TAG) Analyzed by nanoESI/IRMPD; Fabrice Bray1;
Maria Van Agthoven1; Lionel Chiron2, 3; Marie-Aude
Coutouly3; Marc-André Delsuc2; Caroline Tokarski1;
Christian Rolando1; 1Université Lille 1, Sciences et
Technologies, Villeneuve d’Ascq, France; 2Université
de Strasbourg, Strasboug, France; 3NMRTEC,
Illkirch-Graffenstaden, France

PAGE 36					

TOA pm 3:30

Particle-in-Cell Simulation of Image Charge in
Cylindrical and Harmonized ICR Cells; Joshua
Driver1; Andriy Kharchenko1, 2; Ron Heeren2; Eugene
Nikolaev3; Jon Amster1; 1University of Georgia, Athens,
GA; 2FOM Institute for Atomic and Molecular Physics,
Amsterdam, Netherlands; 3Institute for Energy
Problems of Chemical Physics, Moscow, Russia

TOA pm 3:50

The Structure and the Performance of MeshElectrode Linear Ion Trap (MeLIT) Mass Analyzer;
Chuan-Fan Ding; Liang Wang; Fuxing Xu; Fudan
University, Shanghai, CHINA

TOA pm 4:10

Intact Protein Characterization by 193 nm
Ultraviolet Photodissociation in an Orbitrap Elite;
Jared B. Shaw; Jennifer S. Brodbelt; The University
of Texas, Austin, TX

2:30 – 4:30 PM, TUESDAY AFTERNOON
IMAGING MS: BIOLOGICAL APPLICATIONS
Pierre Chaurand (University of Montreal), presiding
Room L100 (lower level)
TOB pm 2:30

On-Tissue Micro-Extraction: The Key to
Success for Identification of Less Abundant
Proteins in MALDI MSI; Jusal Quanico1, 2; Julien
Franck1; Maxence Wisztorski1; Claire Dauly3;
Robert Day2; Michel Salzet1; Isabelle Fournier1;
1
FABMS, Villeneuve D’Ascq, France; 2Institute de
Pharmacologie de Sherbrooke, Sherbrooke, Canada;
3
Thermo Fisher Scientific France, Paris, France

61ST ASMS CONFERENCE ON MASS SPECTROMETRY

TUESDAY AFTERNOON ORAL SESSIONS

TOB pm 2:50

Molecular Diagnosis of Atypical Spitzoid
Neoplasms using Direct Tissue Profiling Mass
Spectrometry; Erin H. Seeley1; Rossitza Lazova2;
Alireza Sepehr3; Richard M. Caprioli1; 1Vanderbilt
University, Nashville, TN; 2Yale University, New
Haven, CT; 3Harvard Beth Israel Deaconess Medical
Center, Boston, MA

TOB pm 3:10

Differential Molecular Profiling of Lipids and
Glycans at the Tumor Margin of Clear Cell Renal
Carcinoma Tissues by MALDI-MS Imaging;
Richard R Drake1; Thomas Powers1; E. Ellen Jones1;
Anand Mehta2; Raymond Lance3; Dean Troyer4;
1
Medical University of South Carolina, Charleston,
SC; 2Drexel Institute for Biotechnology and Virology,
Doylestown, PA; 3Urology of Virginia, Norfolk, VA;
4
Eastern Virginia Medical School, Norfolk, VA

TOB pm 3:30

TOB pm 3:50

TOB pm 4:10

Development of Mass Spectrometry Imaging and
LESA Techniques to Assess Region-Specific
Corticosteroid Regeneration in Brain Assessed
by Mass Spectrometry Imaging; C. Logan
Mackay1; Diego Cobice2; Andrew McBride2; Pat
Langridge Smith1; Scott Webster2; Brian Walker2;
Ruth Andrew2; 1School of Chemistry, University of
Edinburgh, Edinburgh, UK; 2QMRI, University of
Edinburgh, Edinburgh, UK
Molecular Signatures of Mouse Embryo
Implantation Sites using Nanospray Desorption
Electrospray Ionization Imaging Mass
Spectrometry; Ingela Lanekoff1; Kristin Burnum1;
Jeeyeon Cha2; Mathew Thomas1; James Carson1;
Sudhansu K Dey2; Julia Laskin1; 1PNNL, Richland,
WA; 2Cincinnati Childrens’s Hospital Medical Center,
Cincinnati, OH
Macroscopic Imaging Mass Spectrometry: 3D
Surface Mass Spectrometry of a Man and a
Woman; Christopher M Rath1, 2; Mingxun Wang3;
Guo Yurong1; Antonio Gonzalez Pena4; Donna BergLyons4; Gail Ackermann4; Kathleen Dorrestein1;
Robert Knight4; Nuno Bandeira3; Theodore
Alexandrov1, 5; Pieter Dorrestein1, 6; 1School of
Pharmacy, U. Califronia, San Diego, CA; 2Current:
Novartis Institute for Biomedical Res., Emeryville, CA;
3
Center for Computational Mass Spectrometry, UCSD,
San Diego, CA; 4Chemistry and Biochemistry, U.
Colorado Boulder, Boulder, CO; 5Center for Industrial
Mathematics, U. Breman, Breman, Germany;
6
Chemistry and Biochemistry, UCSD, San Diego, CA

TOC pm 3:10

Characterization of an IgG1 Biosimilar Candidate
by High-Resolution Mass Spectrometry Methods;
Susanne Hensel; Stefanie Janzen; Gerhard Koerting;
Stephanie Felske-Mueller; Andreas Wattenberg;
Martin Blueggel; Protagen Protein Services GmbH,
Dortmund , Germany

TOC pm 3:30

Assessing ‘Scrambled’ Disulfide Linkages:
A Comprehensive Workflow for Routine
Characterization of Biotherapeutics using
High-Resolution LCMS and Electron Transfer
Dissociation; Asish Chakraborty; Stephane Houel;
Henry Shion; Scott Berger; Weibin Chen; Waters
Corporation, Milford, MA

TOC pm 3:50

Detailed Glycomic Characterization of
Commercial Erythropoietin (EPO) Variants;
Myung Jin Oh1; Serenus Hua1; Chanyoung Han1; Ha
Neul Jeong1; Gregory Staples2; Jong Shin Yoo1, 3;
Rudolf Grimm1, 2; Hyun Joo An1; 1Chungnam National
University, Daejeon, Korea; 2Agilent Technologies,
Santa Clara, CA; 3Korea Basic Science Institure,
Ochang, Korea

TOC pm 4:10

LC-Fluorescence-MS/MS Assessment of
Bioreactor Parameters on IgG Glycosylation;
John Schiel1; Karen Phinney1; Cyrus Agarabi2; Erik
Read2; Kurt Brorson2; 1NIST, Gaithersburg, MD;
2
CDER, FDA, Silver Spring, MD

2:30 – 4:30 PM, TUESDAY AFTERNOON
PHOSPHOPROTEOMICS
Susan Abbatiello (Broad Inst of Harvard & MIT), presiding
Ballroom A
TOD pm 2:30

A Lower Limit on the Size of the Human Cancer
Cell Line Phospho-Proteome; Kirti Sharma;
Rochelle C J D’souza; Juergen Cox; Igor Paron;
Stefka Tyanova; Matthias Mann; Max Planck Institute
for Biochemistry, Martinsried (Near Munich), Germany

TOD pm 2:50

LuciPHOr: A Powerful Algorithm for
Phosphorylation Site Localization with False
Localization Rate Estimation using Target-Decoy
Approach; Damian Fermin1; Scott Walmsley1;
Anne-Claude Gingras2, 3; Hyungwon Choi4; Alexey
Nesvizhskii1; 1University of Michigan, Ann Arbor,
MI; 2University of Toronto, Toronto, ON; 3Samuel
Lunenfeld Research Institute, Toronto, ON; 4National
University of Singapore, Singapore

TOD pm 3:10

A Novel Phosphopeptide Standard to
Evaluate Data Interpretation in a Realistic
Phosphoproteomic Environment; Sonja Radau1;
Marc Vaudel1; Florian Beck1; Ingo Feldmann1;
Lennart Martens2; Albert Sickmann1; René Zahedi1;
1
Leibniz – Institut für Analytische Wissenschaften,
Dortmund, Germany; 2Department of Medical Protein
Research, VIB, Ghent, BE

TOD pm 3:30

Effect of Post-Excision-Delay-to-Freezing Time
on Protein Phosphorylation of Tumors: A Study
by the NCI Clinical Proteomics Tumor Analysis
Consortium (CPTAC); Philipp Mertins1; DR Mani1;
Vladislav Petyuk2; Tao Liu2; Feng Yang2; Aaron
Gajadhar3; Hannah Johnson3; Hui Zhang4; Douglas
Levine5; Reid Townsend6; Sherri Davies6; Michael
Gillette1; Kelly Ruggles7; David Fenyo7; Karl Clauser1;
Jana Qiao1; Marina Gritsenko2; Shunqiang Li6;
Bai Zhang4; Yuan Tian4; Ronald Moore2; Narcisco
Olvera5; Fanny Dao5; Daniel Chan4; Daniel Liebler9;
Karin Rodland2; Gordon Mills8; Richard Smith2;
Amanda Paulovich10; Matthew Ellis6; Forest White3;
Steven Carr1; NCI CPTAC Consortium11; 1The Broad

2:30 – 4:30 PM, TUESDAY AFTERNOON
CHARACTERIZATION OF
PRODUCT VARIANTS IN BIOSIMILARS
Tracie Williams (Ctr for Disease Control & Prevention), presiding
Ballroom B
TOC pm 2:30

TOC pm 2:50

Use of Stable Isotope-Labeled Reference
Standards and Antioxidants for Reliable
Evaluation of Methionine Oxidation by LC-MS/
MS in Therapeutic Proteins; Pilsoo Kang1; Tanya
Mezhebovsky1; Wei Chen2; James A. McCardle2;
Sheng Zhang2; Eric Routhier1; Philip Sass1;
1
Morphotek, Exton, PA; 2Cornell University,
Ithaca, NY
Comparability Analysis of Anti-CD20 mAb from
Commercial (MabThera) and RNAi-Mediated
Fucosylation Molecules by Two Orthogonal LCMS Approaches; Chen Li1; Greg Thill2; Anthony
Rossomando2; Shiaw-Lin Wu1; Barry Karger1;
1
Northeastern University, Boston, MA; 2Alnylam
Pharmaceuticals, Cambridge, MA

61ST ASMS CONFERENCE ON MASS SPECTROMETRY						

PAGE 37

TUESDAYGENERAL
AFTERNOON
ORAL SESSIONS
INFORMATION

Non-Volatile Profiling of Whiskies using UHPLC/
QTOF-MS; Thomas S. Collins1, 3; Jerry Zweigenbaum2;
Susan E. Ebeler1; 1U.C. Davis, Davis, CA; 2Agilent
Technologies, Wilmington, DE; 3Treasury Wine
Estates, Napa, CA

Institute, Cambridge, MA; 2Pacific Northwest National
Laboratory, Richland, WA; 3Massachusetts Institute
of Technology, Cambridge, MA; 4Johns Hopkins,
Balitmore, MD; 5Memorial Sloan Kettering Cancer
Center, New York, NY; 6Washington University, Saint
Louis, MO; 7New York University, New York, NY;
8
MD Anderson, Houston, TX; 9Vanderbilt University,
Nashville, TN; 10Fred Hutchinson Cancer Research
Center, Seattle, WA; 11National Cancer Institute,
Bethesda, MD

TOE pm 4:10

TOD pm 3:50

SWATH MS Targeted Data Extraction: A
Powerful Method to Resolve False PhosphoSite Assignments in Phosphopeptides; Ludovic
C. Gillet1; Alessio Maiolica1; Pedro Navarro1; Umut
Toprak1; Christina Ludwig1; Ruedi Aebersold1, 2; 1Dept
Biology, IMSB, ETH Zurich, Zurich, Switzerland;
2
Faculty of Science, University of Zurich, Zurich,
Switzerland

TOF pm 2:30

TOD pm 4:10

Investigating Kinase Targets in Neurodegeneration
using Mass Spectrometry; Donald S Kirkpatrick;
Daisy Bustos; Zejuan Sheng; Shuo Zhang; Sarah
Huntwork-Rodriguez; Christine Pozniak; Tracy
Kleinheinz; Claire Le Pichon; Anthony Estrada;
Kimberley Scearce-Levie; John Moffat; Joseph
Lewcock; Haitao Zhu; Genentech, Inc., South San
Francisco, CA

Structure and Interactions of Membrane-Bound
Peptides and Proteins Studied in Detergent
Micelles by nano-ESI IMS-MS/MS; Albert
Konijnenberg1; Jeroen van Dyck1, 3; Jens Obbels1;
Frederik Lermyte1; Frank Sobott1, 2; 1Biomolecular
Mass Spec., University of Antwerp, Antwerpen,
Belgium; 2Center for Proteomics, University of
Antwerp, Antwerpen, Belgium; 3Radboud University,
Nijmegen, The Netherlands

TOF pm 2:50

MS-based Investigation of Tertiary and Quaternary
Interactions in the 5’-Untranslated Region of HIV-1
Genomic RNA; Daniele Fabris; Papa-Nii Asare Okai;
Jennifer Lippens; Maria Basanta Sanchez; Matteo
Scalabrin; The RNA Institute, University at Albany,
Albany, NY

TOF pm 3:10

Structural Mass Spectrometry to Interrogate
Microbial Metabolomes for Natural Product
Prioritization; Cody Goodwin1; Dagmara Derewacz1;
Ruwan Kurulugama2; Ed Darland2; Brian Bachmann1;
John McLean1; 1Vanderbilt Univ Dept of Chem,
Nashville, TN; 2Agilent Technologies, Santa Clara, CA

TOF pm 3:30

Application of Ion Mobility Mass Spectrometry
to Analysis of Biological Samples; Qi Wang1;
Kshitij Khatari1; Ying Zhou1; Crystal Cody2; Ruwan
Kurulugama2; Ed Darland2; Erin Baker3; Joseph Zaia1;
Catherine E. Costello1; 1Boston University School of
Medicine, Boston, MA; 2Agilent Technologies, Santa
Clara, CA; 3Pacific Northwest National Laboratory,
Richland, WA

TOF pm 3:50

Do Electrosprayed Protein Ions Retain Memory
of their Solution Phase Structure? Insights from
Ion Mobility Mass Spectrometry; Siavash Vahidi;
Bradley B. Stocks; Lars Konermann; Univ. of Western
Ontario, London, Canada

TOF pm 4:10

Collision Cross Sections: The Effects of Size,
Shape and Bath Gas; Michael T. Bowers; Christian
Bleiholder; Thomas Wyttenbach; University of
California, Santa Barbara , CA

2:30 – 4:30 PM, TUESDAY AFTERNOON
FOOD SAFETY: ADVANCES IN MS FOR CHARACTERIZATION OF
ADDITIVES AND CONTAMINANTS
Adrian Hegeman (University of Minnesota), presiding
Auditorium
TOE pm 2:30

Screening Large Sample Sets for Contaminants
by DART-MS: Limitations & Advantages; Luke
Ackerman1; Karim Bentayeb2; Timothy Begley1; 1FDA
Center for Food Safety, College Park, MD; 2Univ.
Zaragoza, Analytical Chem, Zaragoza, Spain

TOE pm 2:50

Mass Accuracy and Isotopic Abundance
Measurements in Complex Sample Matrices:
Capabilities of HR-MS Instrumentation for NonTargeted Analyses; Ann M. Knolhoff; Timothy R.
Croley; John H. Callahan; FDA/CFSAN, College Park,
MD

TOE pm 3:10

TOE pm 3:30

TOE pm 3:50

Sample Class Prediction for the Determination
of Off-Flavors in Cranberries by GC/MS; Jean
Francois Sylvain2; Cindy Ricard2; Stephan Baumann1;
Dave Peterson1; Marcus Kim1; 1Agilent Technologies,
Inc., Santa Clara, CA; 2Atoka Cranberries Inc,
Manseau (Québec), Canada
On-Site Screening for Plasticizers, Melamine, and
Residual Pesticides in Tainted Foods via Mobile
Ambient Mass Spectrometry (MAMS); Christopher
Shiea1; Chih-Chiang Chou2; Min-Zong Huang2;
1
Kaohsiung Medical University, Kaohsiung, Taiwan;
2
National Sun Yat-Sen University, Kaohsiung, Taiwan
Preventing Wine Spoilage: Rapid Screening
and Quantitative Analysis of Off-flavor Phenolic
Compounds by DART Mass Spectrometry;
Elizabeth Crawford1; Paola Domizio2; Brian
Musselman3; Lucy Joseph4; Linda Bisson4; Bart
Weimer5; Richard Jeannotte5; 1Institute of Chemical
Technology Prague, Prague, Czech Republic;
2
Università degli Studi di Firenze, Florence, Italy;
3
IonSense, Inc., Saugus, MA; 4UC-Davis Dept. of
Viticulture & Enology, Davis, CA; 5UC-Davis Dept. of
Health and Reproduction, Davis, CA

PAGE 38					

2:30 – 4:30 PM, TUESDAY AFTERNOON
ION MOBILITY: STRUCTURES
Erin Baker (Pacific Northwest National Lab) presiding
Room 101

2:30 – 4:30 PM, TUESDAY AFTERNOON
METABOLITES: UNUSUAL AND UNCOMMON
Paul Thomas (Northwestern University), presiding
Room 102
TOG pm 2:30

Network Based Discovery of Known Unknowns;
Laura Sanchez1; Jane Yang1; Chris Rath1; Paul
Boudreau2; Xueting Liu1; Nicole Bruns2; Anne Wodtke2;
Rafael de Felicio2; Amanda Fenner2; Evgenia
Glukhov2; William Gerwick2; Pieter Dorrestein1;
1
UCSD, La Jolla, CA; 2Scripps Institution of
Oceanography, La Jolla, Ca

TOG pm 2:50

The World of Acylpolyamines, Beta Carbolines,
and Biogenic Amines: Understanding the
Diversity of Spider Venoms through LC-IT-TOF
Mass Spectrometry; Daniel Menezes Saidemberg1;
Nicoli Barão Baptista Saidemberg2; Mario Sergio
Palma3; 1Shimadzu do Brasil, São Paulo/SP, BRAZIL;

61ST ASMS CONFERENCE ON MASS SPECTROMETRY

TUESDAY AFTERNOON ORAL SESSIONS

Endocrine Pancreas Laboratory/IB/UNICAMP,
Campinas/SP, Brazil; 3LBEZ/CEIS/IB/UNESP, Rio
Claro/SP, Brazil
2

TOG pm 3:10

Integrated Metabolomics Approach Enables
Discovery of Novel Natural Products from
Streptomyces coelicolor A3(2); Erin Carlson;
Indiana University, Bloomington, IN

TOG pm 3:30

Identification of Imidacloprid Metabolites in
Onion using High Resolution Mass Spectrometry
and Accurate Mass Tools; Jerry Zweigenbaum1;
Michael Thurman2; Imma Ferrer2; Paul Zavitsanos1;
1
Agilent Technologies, Wilmington, DE; 2University of
Colorado, Boulder, Co

TOG pm 3:50

TOG pm 4:10

TOH pm 2:50

TOH pm 3:10

TOH pm 3:30

TOH pm 3:50

Biemann Medal
Yinsheng Wang
University of California, Riverside

Automated Structure Elucidation of Unknown
Metabolites In Metabolomics and Pharmaceutical
Studies using the Masspec Algorithm and Tandem
Mass Spectral Data; Marshall M. Siegel; Gary Walker;
MS Mass Spec Consultants, Fair Lawn, NJ

Specialized Metabolite Discovery in
Microorganisms through Visualization of
Living Metabolomes using Live-Colony Mass
Spectrometry and Molecular Networking; Jeramie
Watrous1; Paul Boudreau2; Mingxun Wang1; Menno
vander Voort3; George Dimopoulos4; Nuno Bandeira1;
William Gerwick2; Pieter Dorrestein1, 2; 1UCSD, La
Jolla, CA; 2Scripps Institute of Oceanography, La Jolla,
CA; 3Wageningen University, Wageningen, Netherlands;
4
Johns Hopkins University, Baltimore, MD
Applications of an in situ Microextraction Based
Surface Sampling System to Microorganism
Analysis; Mariam S Elnaggar1; Cheng-Chih Hsu2;
Xueting Liu3; Pieter Dorrestein2; Bartek Rajwa4; Justin
Wiseman1; 1Prosolia, Inc., Indianapolis, IN; 2University
of California, San Diego, CA; 3Inst. of Microbiology,
Chinese Academy of Sciences, Peking, China;
4
Purdue University, Lafayette, IN
Identification of Bacteria Using Rapid Evaporative
Ionization Mass Spectrometry; Nicole Strittmatter;
Emrys A. Jones; Monica Rebec; Zoltan Takats;
Imperial College London, London, UK
Rapid Identification of Intact Biothreat Viruses
using MALDI Mass Spectrometry; Lisa H. Cazares1;
Julie Constantino2; Rekha Panchal2; Sina Bavari2;
1
Geneva Foundation/USAMRIID, Frederick, MD;
2
USAMRIID, Ft. Detrick, MD
Combination of Intact Cell Immunocapture and
Multiplexed SRM Mass Spectrometry for the
Sensitive and Specific Detection of Yersinia
Pestis; Jérôme Chenau1, 2; Stéphanie Simon1; Sofia
Filali2; François Fenaille1; Hervé Volland1; Christophe
Junot1; Elisabeth Carniel2; François Becher1; 1CEA,
DSV/iBiTec-S/SPI, Gif Sur Yvette Cedex, France;
2
Institut Pasteur, Unité de recherche Yersinia, Paris,
France

Development and Application of Assays for
Targeted MS Analysis of the Complete Proteome
of Mycobacterium tuberculosis by SRM and
SWATH-MS; Olga Schubert1; Christina Ludwig1;
Jeppe Mouritsen1; Hannes Roest1; George
Rosenberger1; Patrick Arthur2; Manfred Claassen1;
Dave Campbell3; Zhi Sun3; Terry Farrah3; Martin
Gengenbacher4; Stefan H. E. Kaufmann4; Robert
Moritz3; Ruedi Aebersold1; 1ETH Zurich, Zurich,
Switzerland; 2University of Ghana, Accra, Ghana;
3
Institute for Systems Biology, Seattle, WA; 4Max
Planck Insitute for Infection Biology, Berlin, Germany

4:45 - 5:30 PM, TUESDAY
AWARD LECTURE
Susan T. Weintraub (Univ of Texas HSC-San Antonio), presiding
Exhibit Hall A, Lower Level

Effective Detection and Structural
Characterization of Uncommon Drug Metabolites
using High Resolution Mass Spectrometry and
Real-Time Polarity-Switching; Qian Ruan; Mingshe
Zhu; Bristol-Myers Squibb, Princeton , NJ

2:30 – 4:30 PM, TUESDAY AFTERNOON
MICROORGANISMS: IDENTIFICATION AND CHARACTERIZATION
Franco Basile (University of Wyoming), presiding
Room 103
TOH pm 2:30

TOH pm 4:10

5:45 - 7:00 PM, TUESDAY AFTERNOON
WORKSHOPS
Light snacks are provided on level two.

•
•

•

Level One Rooms
Environmental Applications of FTMS: Earth, Air & Water
(organized by the FTMS Interest Group), Room 1
Jumpstarting Your Career: a Career Development Workshop
(organized by the Young Mass Spectrometrists Interest Group),
Room 2
The Galaxy Framework as a Solution for MS-based Informatics,
Room 3
Level Two Rooms

•
•
•

•
•
•
•

•

LC-MS in the Clinical Lab: How Close is 24/7? (organized by the
Clinical Chemistry Interest Group), Room 200 DE
Normalization Approaches to Imaging Mass Spectral Data
(organized by the Imaging MS Interest Group), Room 200 FG
How to Work with your P.I.s More Effectively (and Without Them
Knowing It) (organized by the Analytical Lab Managers Interest
Group), Room 200 H
Current Topics in Metal Ion Chemistry (organized by the Metal
Ion Coordination Chemistry Interest Group), Room 200 I
Ion Mobility MS: New Instrumentation & Enabling Technologies
(organized by the Ion Mobility MS Interest Group), Room 205 AB
Quantitative Intact Proteomics (organized by the Quantitative
Intact Proteomics Interest Group), Room 205 CD
Large Molecule by LC-MS Bioanalytical Method Validation
(BMV): Status, Challenges, Solutions, Recommendations
(organized by the Regulated Bioanalysis Interest Group), Room
208 AB
Practical ETD, Room 208 CD

AFTER 8:00 PM
CORPORATE HOSPITALITY SUITES
HILTON MINNEAPOLIS HOTEL

61ST ASMS CONFERENCE ON MASS SPECTROMETRY						

PAGE 39

WEDNESDAY
MORNING
ORAL SESSIONS
GENERAL
INFORMATION

8:30 – 10:30 AM, WEDNESDAY MORNING
PTMs: ADVANCES IN ISOLATION,
DERIVATIZATION AND SEPARATION
Laszlo Prokai (University of North Texas), presiding
Exhibit Hall A (lower level)
WOA am 08:30 Tyrosine-Selective Phosphopeptide Enrichment
by Chemical and Immuno-Affinity Approaches;
Shigeharu Yoshida; Mayu Ogura; Masaki
Wakabayashi; Naoyuki Sugiyama; Yasushi
Ishihama; Kyoto University, Kyoto, Japan
WOA am 08:50 A General Strategy for Enrichment, Site-Specific
Identification, and Quantification of Multiple
Types of Redox Modifications on Protein Thiols;
Jia Guo; Dian Su; Matthew Gaffrey; Yi Qu; Anil
Shukla; Ronald Moore; Brian Thrall; Richard Smith;
Weijun Qian; Pacific Northwest National Lab,
Richland, WA
WOA am 09:10 Reductive Methylation of Ubl Isopeptides (RUbI):
An Elegant Method for the Enhanced Detection
of SUMO and Ubiquitin Modified Peptides; Navin
Chicooree1, 2; Yvonne Connolly1; Duncan Smith1;
John Griffiths 1; 1Paterson Institute for Cancer
Research, Manchester, UK; 2School of Chemistry,
University of Manchester, Manchester, UK
WOA am 09:30 Improved Enrichment of S-Nitrosylated Peptides
using Iodoacetyl Tandem Mass Tag Reagents,
Immbolized Anti-TMT Antibody Resin and TMT
Elution Buffer; Ryan Bomgarden1; Zhe Qu3; Eric
Hommema1; Rosa Viner2; Zezong Gu3; John C.
Rogers1; 1ThermoFisher Scientific, Rockford, IL;
2
Thermo Fisher Scientific, San Jose, CA; 3University
of Missouri, Columbia, MO
WOA am 09:50 Evaluation of a Novel Tandem Mass Tag for
Profiling of Protein Carbonylation; Somi Afiuni1;
Sergei I. Snovida2; Ryan D. Bomgarden2; John C.
Rogers2; Timothy J. Griffin1; 1University of Minnesota,
Minneapolis, MN; 2Thermo Fisher Scientific,
Rockford, IL
WOA am 10:10 Serial Enrichment of Post-Translationally
Modified Peptides Enables Deep and Quantitative
Analysis of the Proteome, Phosphoproteome,
Ubiquitinome, and Acetylome; Jana Qiao; Philipp
Mertins; Jinal Patel; Karl Clauser; DR Mani; Michael
Burgess; Michael Gillette; Jacob Jaffe; Steven Carr;
Broad Institute, Cambridge, MA
8:30 – 10:30 AM, WEDNESDAY MORNING
INFORMATICS: PROTEIN QUANTIFICATION
Brian Searle (Proteome Software, Inc.), presiding
Room L100 (lower level)
WOB am 08:30 Slice: Scalable Data Sharing for Remote Mass
Informatics; Manor Askenazi1; David Fenyo2; 1The
Ionomix Initiative, Arlington, MA; 2NYU Langone
Medical Center, New York City, NY
WOB am 08:50 IdpQuantify : Combining Precursor Intensity
with Spectral Counts for Protein and Peptide
Quantification; Yao-Yi Chen1; Matthew Chambers1;
Amy-Joan Ham2; Ming Li1; David Tabb1; 1Vanderbilt
University Medical School, Nashville, TN; 2Belmont
University College of Pharmacy, Nashville, TN
WOB am 09:10 Avoiding Arbitrary Parameters in Quantitative
Proteomics: Is “Differential” a 1.1-Fold or 1.2Fold Change? Oliver Serang; Ertugrul Cansizoglu;
Hanno Steen; Judith Steen; Harvard Medical School/
Boston Children’s Hospital, Boston, MA

PAGE 40					

WOB am 09:30 Electrospray Current Fluctuations and other
Instrumental Response Instabilities –In
silico Correction Method Improves Precision
of Label-free Proteomics Quantification;
Yaroslav Lyutvinskiy1; Hongqian Yang1; Dorothea
Rutishauser1; Roman Zubarev1, 2; 1Karolinska
Institutet, MBB, Stockholm, Sweden; 2Science for
Life Laboratory, Stockholm, Sweden
WOB am 09:50 Pre- and Postprocessing Steps in Affinity
Purification Mass Spectrometry Data – More
Reliable Detection of Interaction Candidates;
Martina Fischer1; Susann Zilkenat2; Samuel Wagner2,
3
; Bernhard Y Renard1; 1Robert-Koch-Institute,
Berlin, Germany; 2IMIT, Eberhard Karls University
Tübingen, Tübingen, Germany; 3German Center for
Infection Research (DZIF), Tübingen, Germany
WOB am 10:10 Statistical Selection of Informative Features
for Protein Quantification in Data-Independent
Spectral Acquisition; Ching-Yun Chang1; Nathalie
Selevsek2; Ludovic Gillet2; Hannes Roest2; Ruedi
Aebersold2, 3; Olga Vitek1, 4; 1Department of Statistics,
Purdue University, West Lafayette, IN; 2IMSB, ETH,
Zürich, Switzerland; 3Faculty of Science, University
of Zürich, Zürich, Switzerland; 4Department of
Computer Science, Purdue University, West
Lafayette, IN
8:30 – 10:30 AM, WEDNESDAY MORNING
CARBOHYDRATES: NEW MS APPROACHES
Yehia Mechref (Texas Tech University), presiding
Ballroom B
WOC am 08:30 Obtaining Linkage Information from Linear
Oligosaccharides via MSn (n>2) and Z1 Ions;
Chiharu Konda1; Brad Bendiak2; Yu Xia1; 1Purdue
University, West Lafayette, IN; 2University of
Colorado Denver, Aurora, CO
WOC am 08:50 Trivalent Metal-Assisted Electron Capture
Dissociation and Electron Transfer Dissociation
of Underivatized Glycans; Di Gao; Kristina
Hakansson; University of Michigan, Ann Arbor, MI
WOC am 09:10 Glycan Structural Analysis on the LC Time Scale
Employing Electron Activated Dissociation (ExD)
Methods; Cheng Lin; Xiang Yu; Yan Jiang; Yu
Huang; Joseph Zaia; Catherine E. Costello; Boston
University School of Medicine, Boston, MA
WOC am 09:30 Semi-Automated Sequencing Of Affinity-Purified
Heparan Sulfate Oligosaccharides; Rongrong
Huang; Eduard Condac; Yulun Chiu; Christian Heiss;
Mayumi Ishihara; Muchena J. Kailemia; Jon Amster;
Parastoo Azadi; Lianchun Wang; Joshua S. Sharp;
University of Georgia, Athens, GA
WOC am 09:50 Use of Field Asymmetrical Ion Mobility
Spectrometry (FAIMS) and Tandem Mass
Spectrometry for Structural Characterization
of Isobaric Mixtures of Glycosaminoglycans;
Muchena Kailemia1; Yuejie Zhao1; Isaac Agyekum1;
Andre Venot1; Melvin Park2; Desmond Kaplan2;
Geert-Jan Boons1; Robert Linhardt3; Jon Amster1;
1
University of Georgia, Athens, GA; 2Bruker
Daltonics, Billerica, MA; 3Rensselaer Polytechnic
Institute, Troy, NY
WOC am 10:10 Production of a 13C-Labeled Internal Standard
for Quantitative Glycomics; Evelyn Rampler1;
Shujuan Tao2; Stephan Hann1; Friedrich Altmann1;
Ron Orlando2; Gunda Koellensperger1; 1University
Boku Vienna, Vienna, Austria; 2University of Georgia,
Athens, GA

61ST ASMS CONFERENCE ON MASS SPECTROMETRY

WEDNESDAY MORNING ORAL SESSIONS

8:30 – 10:30 AM, WEDNESDAY MORNING
QUANTITATIVE ANALYSIS BY MS IN DRUG DISCOVERY AND
DEVELOPMENT: NOVEL APPROACHES
Jim Shen (Bristol-Myers Squibb), presiding
Ballroom A
WOD am 08:30 A New Twist on an Old Experiment: Leveraging
Automation and LC-MS/MS to Understand and
Reduce Variability in Plasma Protein Binding;
Lucinda Cohen1; Haiping Wang1; Matt Zrada2; Ken
Anderson2; Ravi Katwaru1; Xinchun Tong1; Bernard
Choi1; Paul Harradine1; Vince Tong1; Natasa
Pajkovic2; Kathy Cox1; 1Merck & Co., Inc., Rahway,
NJ; 2Merck & Co., Inc, West Point, PA
WOD am 08:50 Using 13C and 15N Isotopomer Metabolic Flux
via Glucose and Glutamine to Understand
Cancer’s Metabolic Dependencies by SRM-LCMS/MS; Susanne Breitkopf1, 2; Min Yuan1; Costas
Lyssiotis1, 2; John M Asara1, 2; 1Beth Israel Deaconess
Medical Center, Boston, MA; 2Harvard Medical
School, Boston, MA
WOD am 09:10 PaperSpray Technology for Quantitative
Analysis: Applications in Research and
Regulated Bioanalysis; Jennifer Cunliffe1; Luis
Ramos1; Ann Brown2; Shawn Harriman2; Michael
Hayes1; Jakal Amin2; Jimmy Flarakos1; 1Novartis DMPK,
East Hanover, NJ; 2Novartis MAP, Cambridge, MA
WOD am 09:30 Strategies for the Quantitation of Nucleotides in
Human Plasma using Novel Ion-Pair Hydrophilic
Interaction Chromatography Coupled with
Tandem Mass Spectrometry; Guodong Zhang;
Annie Walker; Zhaosheng Lin; Xiaogang Han;
Matthew Blatnik; Rick Steenwyk; Elizabeth Groeber;
Pfizer Inc., Groton, CT
WOD am 09:50 Optimization of a High-Throughput Metabolic
Soft Spot Assay with Pooled Sample Analysis
and Software-Assisted Structure Elucidation;
Anthony Paiva; Cheryl Klakouski; Tatyana Zvyaga;
Benjamin Johnson; Jonathan Josephs; W. Griffith
Humphreys; Harold Weller; Wilson Shou; BristolMyers Squibb Company, Wallingford, CT
WOD am 10:10 New Quadratic Calibration Approaches for
LC-MS Bioanalysis: Impact of Calibrator
Concentrations and Their Distribution on
Accuracy of Quadratic Regression; Aimin Tan;
Kayode Awaiye; Fethi Trabelsi; BioPharma Services
Inc., Toronto, Canada
8:30 – 10:30 AM, WEDNESDAY MORNING
INSTRUMENTATION: NEW DEVELOPMENTS IN HIGH
RESOLUTION AND MASS ACCURACY
Steve Patrie (UT Southwestern Medical Center), presiding
Auditorium
WOE am 08:30 The Way to Isotopic Resolution of Mega Dalton
Protein Mass Spectra for Top-Down Proteomics;
Eugene Nikolaev1, 2; 1Institute for Energy Problems
of Chemical Physics, Moscow, Russia; 2Emanuel
Institute of Biochemical Physics, Moscow, Russia
WOE am 08:50 Accelerating High Resolution Mass
Spectrometry by Advanced Signal Processing
and Allied Technique Development; Yury O.
Tsybin1; Tagir Aushev2; Luca Fornelli1; Kristina
Srzentić1; Konstantin O. Zhurov1; Ünige A. Laskay1;
Philippe Dugourd3; Jérôme Lemoine3; Anton
N. Kozhinov1; 1Ecole Polytechnique Federale,
Lausanne, Switzerland; 2Institute for Theoretical and
Experimental Physics, Moscow, Russia; 3Université
Lyon 1, Villeurbanne, France

WOE am 09:10 Autophaser GA – Absorption Mode Spectra for
All; David Kilgour; Rebecca Wills; Yulin Qi; Peter
O’Connor; Warwick University, Coventry, UK
WOE am 09:30 Measurement of Intact Proteins under NonDenaturating Conditions with nLC-MS Technique
on an Orbitrap Instrument; Olaf Scheibner1;
Michael Trnka2; Shenheng Guan2; Alma Burlingame2;
Phillip Robinson3; Roger Kornberg3; Eugen Damoc1;
Eduard Denisov1; Maciej Bromirski1; 1Thermo Fisher
Scientific GmbH, Bremen, Germany; 2University of
Californi,San Francisco, CA; 3Stanford University
School of Medicine, Stanford, CA
WOE am 09:50 27-Plex Protein Quantification using NeutronEncoded Chemical Tags, Resolution in Excess
of One Million, and a New Hybrid Orbitrap
Mass Spectrometer; Alexander S. Hebert1; Anna
E. Merrill1; Christopher M. Rose1; Derek J. Bailey1;
Jonathan A. Stefely1; David J. Pagliarini1; Jesse
Canterbury2, 3; Vlad Zabrouskov2, 3; Michael Senko2, 3;
Eduard Denisov2, 3; Alexander Makarov2, 3; Michael S.
Westphall1; Joshua J. Coon1; 1University of Wisconsin,
Madison, WI; 2Thermo Fisher Scientific, San Jose,
CA; 3Thermo Fisher Scientific, Bremen, Germany
WOE am 10:10 High Density, High Resolution MS Scans
Dramatically Boost the Number of Precursors
Identifiable and Quantifiable at the MS Level;
Annette Michalski; Nagarjuna Nagaraj; Juergen Cox;
Matthias Mann; MPI of Biochemistry, Martinsried,
Germany
8:30 – 10:30 AM, WEDNESDAY MORNING
EMERGING ENVIRONMENTAL CONTAMINANTS
Kerry Peru (Environment Canada), presiding
Room 101
WOF am 08:30 Organic Components in a Wildfire-Applied Fire
Retardant by Positive And Negative Electrospray
Ionization High Resolution Mass Spectrometry;
Colleen Rostad1; Edward Furlong2; 1USGS, WRD,
National Research Program, Denver, CO; 2USGS,
NWQL, Methods Research & Development
Program, Denver, CO
WOF am 08:50 Mass Spectrometry Characterization and
Determination of Emerging Disinfection
Byproducts in Swimming Pools; Xing-Fang Li;
Wei Wang; Yichao Qian; Jessica Boyd; Rongfu
Huang; University of Alberta, Edmonton, Canada
WOF am 09:10 Integrating Comprehensive Two-Dimensional
Gas Chromatography, (Ultra)High Resolution
Mass Spectrometry and Mass Defect Analysis for
the Identification of Halogenated Environmental
Contaminants; Karl J Jobst1; Eric J Reiner1; Vince Y
Taguchi1; Trudy Watson-Leung1; Dave Poirier1; Dave
Alonso2; Joe Binkley2; Lorne Fell2; 1Ontario Ministry
of the Environment, Toronto, Canada; 2LECO
Corporation, St. Joseph, MI
WOF am 09:30 Exact Mass Screening of 1024 Pharmaceuticals
in Wastewater Samples using QExactive Mass
Spectrometer; Heinz Singer; Annika Woessner;
Christa McArdell; Kathrin Fenner; Eawag - Swiss
Federal Institute of Aquatic Science, Duebendorf,
Switzerland
WOF am 09:50 Large Volume Injection of 900 μL Landfill
Leachate Extracts for Fluorochemicals Analysis
by Orthogonal Diol/C18 HPLC-MS/MS; Mckay
Allred1; Johnsie Lang2; Morton Barlaz2; Jennifer
Field1; 1Oregon State University, Corvallis, OR;
2
North Carolina State University, Raleigh, NC

61ST ASMS CONFERENCE ON MASS SPECTROMETRY						

PAGE 41

WEDNESDAY
MORNING
ORAL SESSIONS
GENERAL
INFORMATION

WOF am 10:10 Are the Results of Non-Target Screening for
Water Contaminants Very Surprising? Christian
Zwiener; Marco Zedda; Christina Schmalz;
University of Tuebingen, Tuebingen, Germany
8:30 – 10:30 AM, WEDNESDAY MORNING
FUNDAMENTALS: ION SPECTROSCOPY (HONORING ROB
DUNBAR’S 70TH BIRTHDAY)
Peter Armentrout (University of Utah), presiding
Room 102
WOG am 08:30 HisGly as a Model for Metal-Ion Binding to
Peptides; Robert C. Dunbar1; Jos Oomens2; Giel
Berden2; Justin Kai-Chi Lau3; Udo H. Verkerk3; Alan C.
Hopkinson3; K. W. Michael Siu3; 1Case Western Reserve
Univ, Cleveland, OH; 2Radboud University, Nijmegen,
Netherlands; 3York University, Toronto, Canada
WOG am 08:50 Infrared Spectroscopy of Anionic Polyaromatic
Hydrocarbons; Juehan Gao2; Giel Berden1, 2;
Jos Oomens1, 2; 1FOM Rijnhuizen, Nieuwegein,
Netherlands; 2Radboud University Nijmegen,
Nijmegen, Netherlands
WOG am 09:10 Polycyclic Aromatic Hydrocarbon Fragment
Ions Studied with an FTICR Mass Spectrometer
Coupled to FELICE; Annemieke Petrignani1, 2;
A.F.G. van der Meer1; Britta Redlich1; A.G.G.M.
Tielens2; Martin Vala4; John R. Eyler 4; Jos Oomens1,
3 1
; FOM Rijnhuizen, Nieuwegein, The Netherlands;
2
Leiden Observatory, Leiden University, Leiden, The
Netherlands; 3IMM, Radboud University, Nijmegen, The
Netherlands; 4University of Florida, Gainesville, FL
WOG am 09:30 Cold Ion Spectroscopy for Structural
Determination of Peptides and Proteins; Oleg V.
Boyarkine; Natalia S. Nagornova; Thomas R. Rizzo;
Vladimir Kopysov; EPFL, Lausanne, Switzerland
WOG am 09:50 IRMPD Spectroscopy: When Does It Reveal
What’s Present? Jacob Schmidt; Steven Kass;
University of Minnesota, Minneapolis, MN
WOG am 10:10 UV Spectroscopy on a Model Hydrogen Storage
Cluster, [Ag3H2 (Ph2P) 2CH2]+; Richard A. J. O’Hair1;
Athanasios Zavras1; George Khairallah1; Marion
Girod2, 3; Rodolphe Antoine2, 4; Philippe Dugourd2, 4;
Luke MacAleese2, 4; Marjan Krstić5; Vlasta BonačićKoutecký5, 6; 1University of Melbourne, Victoria,
Australia; 2Université Lyon 1, Lyon, France; 3Institut
des Sciences Analytiques, Lyon, France; 4Institut
Lumière Matière, Lyon, France; 5University of Split,
Split, Croatia; 6Humboldt-Universität Berlin, Institut
für Chemie, Berlin, Germany

PAGE 42					

8:30 – 10:30 AM, WEDNESDAY MORNING
H/D EXCHANGE: BIOLOGICAL APPLICATIONS
Thomas Jorgensen (Univ of Southern Denmark), presiding
Room 103
WOH am 08:30 The Influence of Adnectin on the Extracellular
Domain of Epidermal Growth Factor Receptor
as Measured by Hydrogen/Deuterium Exchange
Mass Spectrometry; Roxana E. Iacob1; Guodong
Chen2; Hui Wei2; Jingjie Mo2; Daniel Cohen2; Dianlin
Xie2; Zheng Lin2; Paul Morin2; Michael Doyle2;
Adrienne A. Tymiak2; John R. Engen1; 1Northeastern
University, Boston, MA; 2Bristol-Myers Squibb
Company, Princeton, NJ
WOH am 08:50 Effector Binding Causes Major Changes in the
Structure and Dynamics of the ClpP Protease
Complex: A HDX/MS Investigation; Modupeola
Sowole1; John Alexopoulos2; Joaquin Ortega2; Lars
Konermann1; 1University of Western Ontario, London,
Canada; 2Mcmaster University, Hamilton, ON, Canada
WOH am 09:10 Epitope-Distal Effects Accompany the Binding
of Two Distinct Antibodies to Hepatitis B Virus
Capsids; Jessica Bereszczak1; Rebecca Rose1;
Esther van Duijn1; Norman Watts2; Paul Wingfield2;
Alasdair Steven2; Albert Heck1; 1Biomolecular Mass
Spectrometry and Proteomics, Utrecht, The Netherlands;
2
National Institutes of Health, Bethesda, MD
WOH am 09:30 Characterization of Residual Structure in the
Native and Amyloidogenic Tau; Shaolong Zhu;
Tamanna Rob; Derek Wilson; York University,
Toronto, Canada
WOH am 09:50 Rational Design of Novel Insulin Sensitizers
Guided with HDX; David Marciano; Scott Novick;
Bruce Pascal; Michael Chalmers; Theodore
Kamenecka; Patrick Griffin; The Scripps Research
Institute, Jupiter, FL
WOH am 10:10 Higher-Order Structure Characterization of a
Fusion Protein Biopharmaceutical by Hydrogen/
Deuterium Exchange Mass Spectrometry;
George M. Bou-Assaf; Steven A. Berkowitz;
Protein Pharmaceutical Development, Biogen Idec,
Cambridge, MA

10:30 AM - 2:30 PM
WEDNESDAY POSTER SESSION
Exhibit Hall BC
Lunch concessions are open 11:00 am - 2:00 pm

61ST ASMS CONFERENCE ON MASS SPECTROMETRY

WEDNESDAY AFTERNOON ORAL SESSIONS

2:30 – 4:30 PM, WEDNESDAY AFTERNOON
FORENSIC APPLICATIONS
Mary Satterfield (NIST), presiding
Exhibit Hall A (lower level)
WOA pm 2:30

Development and Validation of a LiquidChromatography-High Resolution Mass
Spectrometry Method for the Simultaneous
Analysis of 28 Synthetic Cathinones in Urine;
Sebastien Anizan; Kayla Ellefsen; Marta ConcheiroGuisan; Marilyn A. Huestis; Chemistry and Drug
Metabolism, NIDA / NIH, Baltimore, MD

WOA pm 2:50

Differentiation of African and Brazilian Mahogany
Wood based on the Chemical Profile of
Methanolic Extractives by Electrospray Ionization
Mass Spectrometr; Maíra Fasciotti1; Rodrigo Leal1;
Valnei Cunha1; Romeu Daroda1; Rosana Alberici1, 2;
Marcos Eberlin2; 1inmetro, Duque De Caxias, Brazil;
2
University of Campinas, Campinas, Brazil

WOA pm 3:10

Analysis of Propofol (2,6-Diisopropylphenol)
and Its Metabolites in One Injection using a Dual
Ionization Source; Adrian Taylor1; Larry Campbell1;
Carmai Seto1; Oscar Cabrices2; Takeo Sakuma1; 1AB
SCIEX, Concord, Canada; 2Gerstel Inc, Linthicum, MD

WOA pm 3:30

Development of Species Specific Dating
Technique for Human Bone with Minimal Sample
Consumption; Christopher Rollman; Mehdi Moini;
Smithsonian Institution, Suitland, MD

WOA pm 3:50

WOA pm 4:10

Identification of Non-Synonymous Single
Nucleotide Polymorphisms (nsSNPs) in Hair
Shaft Protein and Utilization to Obtain Measures
of Identity; Tami Leppert1; Krishna Parsawar1;
Jonathan Hilmer2; Lisa Baird1; Brandon Hanberg3;
Jacquie Howard3; Chad Nelson1; Brian Bothner2;
Mark Leppert1; Glendon Parker3; 1University of
Utah, Salt Lake City, UT; 2Montana State University,
Bozeman, MT; 3Utah Valley University, Orem, UT
LC-MS/MS Analysis of Opioids in Urine:
Evaluation of LC-MS/MS Conditions for
Interferences Due to Oxycodone Metabolites;
Marc Rumpler; Lindsay Bazydlo; Bruce Goldberger;
Timothy Garrett; University of Florida, Gainesville, FL

2:30 – 4:30 PM, WEDNESDAY AFTERNOON
PRINCIPLES OF PROTEIN IDENTIFICATION AND
CHARACTERIZATION
Neil Kelleher (Northwestern University), presiding
Room L100 (lower level)
WOB pm 2:30

The Utility of Prior Information such as GPMdb
Frequency and RNAseq Transcript Abundance
for Improved Protein Identification in Shotgun
Proteomics; Avinash Shanmugam; Anastasia K.
Yocum; Alexey Nesvizhskii; University of Michigan,
Ann Arbor, MI

WOB pm 2:50

CPTAC Proteogenomics : Proteogenomics
Analysis of Cancer MS/MS Spectra by Peptide
Level Identification of Genomic Mutations
Expressed in RNA-Seq Data; Sunghee Woo; Seong
Won Cha; Vineet Bafna; UCSD, San Diego, CA

WOB pm 3:10

Discovery and Mass Spectrometric Analysis of
Novel Splice-Junction Peptides using RNA-Seq;
Gloria Sheynkman; Michael Shortreed; Lloyd Smith;
Univ. of Wisconsin Madison, Madison, WI

WOB pm 3:30

An Unsupervised Machine Learning Algorithm for
Positioning Modifications on Phosphopeptides;
Oliver Horlacher; Frederic Nikitin; Frederique
Lisacek; Markus Muller; SIB, Geneva, Switzerland

WOB pm 3:50

Using Prior Knowledge to Improve Scoring
in High-Throughput Top-Down Proteomics
Experiments; Richard LeDuc; Le-Shin Wu; Indiana
University, Bloomington, IN

WOB pm 4:10

Proteogenomics of Immunoglobulins:
Applications to the Clinical Laboratory; Surendra
Dasari; Jason Theis; Robert Bergen, III; Diana Gil;
David Barnidge; Marina Ramirez-Alvarado; Diane
Jelinek; David Murray; Ahmet Dogan; Mayo Clinic,
Rochester, MN

2:30 – 4:30 PM, WEDNESDAY AFTERNOON
GAS-PHASE IONS: REACTIONS, DYNAMICS AND THEORY
Mike Van Stipdonk (Lawrence University), presiding
Ballroom B
WOC pm 2:30 Energetics and Dynamics of the Reactions of
Thorium Cations with Dihydrogen and Methane;
Richard Cox; Peter B. Armentrout; University of Utah,
Salt Lake City, UT
WOC pm 2:50 Charge Site Mass Spectra: Gaseous Protein
Ions Have an Unusual Common Secondary
Structure; Fred W. McLafferty1; Owen S. Skinner2;
Kathrin Breuker3; 1Cornell University, Ithaca, NY;
2
Northwestern University, Evanston, IL; 3University of
Innsbruck, Innsbruck, Austria
WOC pm 3:10 Model Compound Fragmentation Pathways as
an Entry to Structural Analysis of Crude Oil;
Benjamin J. Bythell1; Yuri Corilo1, 2; Vladislav V.
Lobodin1, 2; Ryan Rodgers P. 1, 2; Alan G. Marshall1,
3 1
; National High Magnetic Field Laboratory,
Tallahassee, FL; 2Florida State University Future
Fuels Institute, Tallahassee, FL; 3Florida State
University, Tallahassee, FL
WOC pm 3:30 A Catalytic Cycle for the Formation of a C-C
Bond Catalysed by Bimetallic Ag/Cu; George N.
Khairallah; Halah Al Sharif; Krista Vikse; Richard A.
J. O’Hair; Bio21 Inst,Uni of Melbourne, Melbourne,
Australia
WOC pm 3:50 Variable Temperature Ion Trap Mass Spectrometer
for the Study of Gas-Phase Reactions; David Derkits;
Jared Lamp; Jasmine Harge; Russell Snead; Alexander
Wiseman; Scott Gronert; Virginia Commonwealth
University, Richmond, VA
WOC pm 4:10 Investigating Electron-Induced
Chemiluminescence in Ru3+ (bipy) 3 Acetonitrile
Clusters; Maria Demireva; Evan R. Williams;
University of California, Berkeley, CA
2:30 – 4:30 PM, WEDNESDAY AFTERNOON
BIOMARKERS OF DRUG RESPONSE, EFFICACY AND TOXICITY:
NOVEL MS APPROACHES
Fanyu Meng (Merck & Co), presiding
Ballroom A
WOD pm 2:30 N-terminal Labeling Reveals Circulating
Proteomic Signatures of Cell Death PostChemotherapy; Arun Wiita; James Wells; University
of California, San Francisco, CA
WOD pm 2:50 Protein C Inhibitor Proteotypic Peptide
Quantitation by LC-Free SISCAPA-MALDI Mass
Spectrometry Predicts Recurrence of Prostate
Cancer after Radiotherapy; N. Leigh Anderson1;
Morteza Razavi2; Terry Pearson2; Lisa Johnson3;
Julian Lum3; Gary Kruppa4; 1SISCAPA Assay
Technologies, Washington, DC; 2University of
Victoria, Victoria, BC, Canada; 3Deeley Research Ctr,
BC Cancer Agency, Victoria, BC, Canada; 4Bruker
Daltonics Inc., Billerica, MA

61ST ASMS CONFERENCE ON MASS SPECTROMETRY						

PAGE 43

GENERAL
INFORMATION
WEDNESDAY
AFTERNOON
ORAL SESSIONS

WOD pm 3:10 Evaluation of a Novel Microfluidic Device for
Robust and Ultrasensitive Quantitative Analysis
of Biomarkers and Bio-Therapeutics by LC-MS/
MS; Jose Castro-Perez1; Haihong Zhou1; Vinit
Shah1; Kevin Bateman1; David Mclaren1; Anita
Lee1; Stephen Previs1; Kitshiri Herath1; James
Murphy2; Paul Rainville2; Alan Millar2; Angela
Doneanu2; Michele Cleary1; Thomas Roddy1; 1Merck,
Kenilworth, NJ; 2Waters Corp, Milford, MA
WOD pm 3:30 Quantifying Proteoforms using High-Throughput
Top-Down Proteomics for Cell-Based Biomarker
Discovery; John P. Savaryn1; Adam D. Catherman1;
Archer D. Smith IV1; Ryan T. Fellers1; Richard
D. LeDuc2; Paul M. Thomas1; Neil L. Kelleher1;
1
Northwestern University, Evanston, IL; 2Indiana
University, Bloomington, IN
WOD pm 3:50 Proteomic Analysis Reveals Differences between
Xenograft Models of Triple-Negative Breast
Cancer Associated with Therapy Response;
Nadine Mascini1; Gert Eijkel1; Petra ter Brugge2;
Jelle Wesseling2; Jos Jonkers2; Ron Heeren1; 1FOM
Institute AMOLF, Amsterdam, The Netherlands;
2
The Netherlands Cancer Institute, Amsterdam, The
Netherlands
WOD pm 4:10 Development of Urinary Biomarkers to
Monitor Oligomer Treatment in Duchenne
Muscular Dystrophy; Aiping Zhang; Kitipong
Uaesoontrachoon; Kathryn White; Sree Rayavarapu;
Kristy J Brown; Patricio Ray; Kanneboyina
Nagaraju; John N. van den Anker; Eric P Hoffman;
Yetrib Hathout; children’s National Medical center,
Washington, DC
2:30 – 4:30 PM, WEDNESDAY AFTERNOON
INSTRUMENTATION: NEW DEVELOPMENTS IN IONIZATION
AND SAMPLING
Richard Vachet (University of Massachusetts), presiding
Auditorium

WOE pm 4:10

Off-line Capillary Electrophoresis Mass
Spectrometry Using Patterned Deposition
Nanostructure Assisted Laser Desorption
Ionization; Jon Beusse; Kermit K. Murray; Louisiana
State University, Baton Rouge, LA

2:30 – 4:30 PM, WEDNESDAY AFTERNOON
ECOLOGICAL AND HUMAN HEALTH ENVIRONMENTAL
CHEMISTRY AND TOXICOLOGY
Paul Chiarelli (Loyola University), presiding
Room 101
WOF pm 2:30

Real-Time, Geospatially-Resolved Atmospheric
Contaminant Monitoring by Membrane
Introduction Tandem Mass Spectrometry
(MIMS-MS/MS) Near Oil and Gas Operations in
Alberta, Canada; Ryan J. Bell4; Nicholas G. Davey1,
4
; Morten Martinsen2, 4; Alexander J. Thompson4;
Isobel J. Simpson3; Donald R. Blake3; Erik T.
Krogh1, 4; Christopher G. Gill 1, 4; 1University of
Victoria, Victoria, BC, Canada; 2NTNU, Trondheim,
Norway; 3University of California, Irvine, CA; 4AERL,
Vancouver Island University, Nanaimo, BC, Canada

WOF pm 2:50

LC -Q-TOF-MS and LC –HR-TOF-MS Methods for
the Determination of Metabolites of Polycyclic
Aromatic Hydrocarbons in Urine: A Comparison;
Jutta Lintelmann1; Evelyn Huebner1; Juergen
Wendt2; Ralf Zimmermann1; 1Helmholtz Zentrum
Muenchen, Neuherberg, Germany; 2LECO European
LSCA Centre, Moenchengladbach, Germany

WOF pm 3:10

Simultaneous Determination of Polybrominated
Diphenyl Ethers (BDEs) and Polychlorinated
Biphenyls (PCBs) in Plasma by GC Triple
Quadrupole Mass Spectrometer; Yan-Ping Lin1;
Birgit Puschner1; Isaac N. Pessah1; Keyu Zhou2;
Gwen Lim2; Helen Sun2; Kefei Wang2; 1University of
California, Davis, CA; 2Bruker, Chemical and Applied
Market (CAM) Division, Fremont, CA

WOF pm 3:30

Investigation of Human Body Adaptation to the
High Temperature and High CO2 Level by MS
Analysis of Exhaled Breath Condensate; Alexey
Kononikhin1, 2; Anna Ryabokon2; Igor Popov2, 5;
Nataliia Starodubtseva1, 3; Viktoria Kurova2; Evgeny
Kukaev2, 5; Maria Indeykina1, 2; Alexander Spassky1;
Stanislav Pekov1; Sergey Varfolomeev2; Irina Larina4;
Eugene Nikolaev1, 2; 1Institute for Energy Problems
of Chemical Physics, Moscow, Russia; 2Emanuel
Institute of Biochemical Physics, Moscow, Russia;
3
Research Center for Obstetrics, Gynecology,
Moscow, Russia; 4Institute for Biomedical Problems,
Moscow, Russia; 5Moscow Institute of Physics and
Technology, Moscow, Russia

WOE pm 2:30

A Novel ConDuct Interface for Transmitting
~100% Ions from an ESI Source into a Mass
Spectrometer; Andrew N. Krutchinsky; Julio C.
Padovan; Herbert Cohen; Brian T. Chait; Rockefeller
University, New York, NY

WOE pm 2:50

A New Ionization Method for Volatile and
Nonvolatile Compounds Requiring only Vacuum
and Matrix Assistance; Sarah Trimpin; Wayne
State University, Detroit, MI

WOE pm 3:10

Nanoliter Segmented-Flow Sampling
Mass Spectrometry: Introducing On-line
Compartmentalization while Avoiding Sample
Dilution; Michael Volny 1; Bejan Hakimi1; Joelle
Rolfs1; Petr Frycak2; Thomas Schneider1; Gloria
Yen1; Dingsheng Liu1; Daniel Chiu1; Frantisek
Turecek1; 1University of Washington, Seattle, WA;
2
Palacky University, Olomouc, Czech Republic

WOF pm 3:50

Coupling Gel Electrophoresis to Mass
Spectrometry by Electrostatic Spray Ionization;
Elena Tobolkina1; Liang Qiao1; Liu Baohong2; Hubert
Girault1; 1École Polytechnique Fédérale de Lausanne,
Lausanne, Switzerland; 2Institute of Biomedical
Sciences, Fudan University, Shanghai, China

A New Method for the Analysis of Cyanotoxins
using Laser Diode Thermal DesorptionAtmospheric Pressure Chemical IonizationTandem Mass Spectrometry (LDTD-APCI-MS/
MS); Audrey Roy-Lachapelle; Pascal Lemoine;
Sébastien Sauvé; Université de Montréal, Montréal,
Canada

WOF pm 4:10

Quantitative Determination and Simultaneous
Confirmation by UPLC-MS/MS of Methylhippuric
Acids in the Urine of Workers Exposed to
Xylenes; Sebastien Gagne; IRSST, Montreal,
Canada

WOE pm 3:30

WOE pm 3:50

Large Surface Area Analysis by Spray
Desorption Collection Coupled to Paper Spray
Mass Spectrometry; Andre Venter; Gregg Hasman;
Kevin Douglass; Western Michigan University,
Kalamazoo, MI

PAGE 44					

61ST ASMS CONFERENCE ON MASS SPECTROMETRY

WEDNESDAY AFTERNOON ORAL SESSIONS

2:30 – 4:30 PM, WEDNESDAY AFTERNOON
GLYCOPROTEINS AND GLYCANS: NEW MS APPROACHES
Carthene Bazemore-Walker (Brown University), presiding
Room 102
WOG pm 2:30 Site-Specific Glycan-Peptide Analysis
for Determination of N-Glycoproteome
Heterogeneity; Benjamin Parker1; Morten ThaysenAndersen2; Nestor Solis1; Nichollas Scott1, 3; Martin
Larsen4; Mark Graham5; Nicolle Packer2; Stuart
Cordwell1; 1The University of Sydney, Sydney,
Australia; 2Macquarie University, Sydney, Australia;
3
University of British Columbia, Vancouver, Canada;
4
The University of Southern Denmark, Odense,
Denmark; 5Children’s Medical Research Institute,
Sydney, Australia
WOG pm 2:50 Insights on the Glycopeptides and Glycosylation
Site Mapping of the Atypical Glycans of the
Methanogen Archaeon Methanosarcina mazei;
Deborah R. Leon1; Xiang Yu1; Cheng Lin1; Nancy
Leymari1; Rachel R. Ogorzalek Loo2; Joseph A. Loo3;
Robert P Gunsalus4; Catherine E. Costello1; 1Boston
University School of Medicine, Boston, MA; 2Dept
of Biological Chemistry UCLA, Los Angeles, CA;
3
Dept of Chem and Biochem UCLA, Los Angeles,
CA; 4Microbiol, Immnunol and Molec Genetics Dept
UCLA, Los Angeles, CA
WOG pm 3:10 Low-Flow Sheathless Capillary Electrophoresis Mass Spectrometry for Sensitive High-Resolution
Glycoform Profiling of Intact Pharmaceutical
Proteins; Rob Haselberg1; Gerhardus J. de
Jong2; Govert W. Somsen1; 1AIMMS Division of
BioMolecular Analysis, Amsterdam, the Netherlands;
2
Biomolecular Analysis, Utrecht, the Netherlands
WOG pm 3:30 In Depth Characterization of N-Linked
Oligosaccharides using Fluoride-Mediated
Negative Ion Microfluidic Chip LC-MS; Jonathan
Bones1, 2; Wenqin Ni1; Victoria Berger1; Barry Karger1;
1
Northeastern University, Boston, MA; 2National
Institute for Bioprocessing Research, Dublin, Ireland

2:30 – 4:30 PM, WEDNESDAY AFTERNOON
H/D EXCHANGE: NEW DEVELOPMENTS IN TECHNOLOGY
David Weis (University of Kansas), presiding
Room 103
WOH pm 2:30 Electrochemical Reduction of Disulphide Bonds
for Use in Protein Hydrogen/Deuterium Exchange
Monitored by Mass Spectrometry; Simon Mysling;
Thomas J. D. Jorgensen; BMB, University of
Southern Denmark, Odense, Denmark
WOH pm 2:50 Improvementof Peptic Peptide Identification for
Amide H/D Exchange using High Mass Accuracy
Combined with a Statistical Approach; Jianqing
Wu1; Guillaume van der Rest2; 1Ecole Polytechnique,
Palaiseau, France; 2Université Paris-Sud, Orsay,
France
WOH pm 3:10 Nepenthesin-I – Recombinant Carnivorous Plant
Protease as a Tool for Hydrogen / Deuterium
Exchange Mass Spectrometry; Alan Kadek1,
2
; Hynek Mrazek1, 2; Vyacheslav Tretyachenko2;
Martial Rey3; David Schriemer3; Petr Halada1; Petr
Man1, 2; 1Institute of Microbiology ASCR, Prague,
Czech Republic; 2Charles University, Prague, Czech
Republic; 3University of Calgary, Calgary, Canada
WOH pm 3:30 Microfluidics-Enabled, Sub-Second Hydrogen/
Deuterium Exchange Pulse Labeling Reveals
Allosteric ‘Hotspots’ in Enzymes; Derek Wilson;
Tamanna Rob; Preet Gill; Dasantila Golemi-Kotra;
York University, Toronto, Canada
WOH pm 3:50 Using Isotopic Fine Structure to Resolve
Individual Hydrogen/Deuterium Exchanges; Qian
Liu1; Michael Easterling2; Jeffrey Agar1; 1Brandeis
University, Waltham, MA; 2Bruker Daltonics Inc.,
Billerica, MA
WOH pm 4:10 Information Independent Acquisition of MS/MS
Data for High Efficiency HDX-MS Experiments;
Vladimir Sarpe; David Schriemer; University of
Calgary, Calgary, Canada

4:45 - 5:30 PM, WEDNESDAY AFTERNOON
ASMS MEETING
Susan T. Weintraub, presiding
Ballroom A

WOG pm 3:50 Selected Reaction Monitoring to Differentiate and
Relatively Quantitate Isomers of Sulfated Core
1 O-Glycans from Salivary MUC7 in Rheumatoid
Arthritis; Sarah Flowers1; Liaqat Ali1; Catherine
Lane2; Niclas Karlsson1; 1Gothenburg University,
Gothenburg, Sweden; 2AB Sciex, Warrington, UK

Don’t miss awards, Board reports and more.

WOG pm 4:10 Computational Approach for Identifying Sulfation
Pattern of Heparan Sulfate using High Resolution
Tandem Mass Spectrometry Data; Han Hu; Yu
Huang; Yu Xia; Joseph Zaia; Boston University,
Boston, MA

5:45 - 7:00 PM, WEDNESDAY AFTERNOON
WORKSHOPS
Light snacks are provided on level two.
•
•
•

Level One Rooms
Fundamentals in LC-MS Troubleshooting (organized by LC/MS
& Related Topics Interest Group), Room 1
H/D Exchange and Covalent Labeling (organized by H/D
Exchange & Covalent Labeling Interest Group), Room 2
LC-MS of Glycans and Glycopeptides: Advantages and
Challenges, Room 3

61ST ASMS CONFERENCE ON MASS SPECTROMETRY						

PAGE 45

GENERAL
INFORMATION
WEDNESDAY
AFTERNOON
ORAL SESSIONS

Wednesday Workshops continued
Level Two Rooms
•

Fuel Analysis: Surveying Research Methods and their Application
in Industrial Settings (organized by Energy, Petroleum & Biofuels
Interest Group), Room 200 DE

•

Emerging Contaminants in Environmental Research: Hydraulic
Fracturing Fluids and Shale Gas Produced Waters - Advances,
Challenges and Opportunities using mass spectrometry
(organized by Environmental Applications Interest Group), Room
200 FG

•

The Advancement of Polymer Mass Spectrometry (organized by
Polymeric Materials Interest Group), Room 200 H

•

Challenges and New Directions in Plant Proteomics, Room 200 I

•

CHORUS – A Community Solution for the Storage, Visualization,
and Sharing of Mass Spectrometry Data on the Cloud,
Room 200 J

•

Ion Structures and Energetics, and Ion-Molecule Reaction
Kinetics in the Gas Phase, in honor of Peter B. Armentrout’s
60th birthday (organized by Fundamentals Interest Group),
Room 205 AB

•

Proteins and Peptides as Pharmaceutical Agents (organized by
Pharmaceuticals Interest Group), Room 205 CD

•

Lipid Mass Spectrometry & Lipidomics, Room 208 AB

•

Mass Spectrometry Applications in Art, Cultural Heritage, and
Natural History, Room 208 CD
AFTER 8:00 PM
CORPORATE HOSPITALITY SUITES
HILTON MINNEAPOLIS HOTEL

THURSDAY MORNING ORAL SESSIONS
8:30 – 10:30 AM, THURSDAY MORNING
AMBIENT IONIZATION: INSTRUMENTATION AND APPLICATIONS
Justin Wiseman (Prosolia, Inc.), presiding
Exhibit Hall A (lower level)
ThOA am 08:30 Progress toward Universal Ionization by
Combining Different Ambient Ionization
Methods; Robert B. Cody; John Dane; JEOL USA,
Inc., Peabody, MA
ThOA am 08:50 Development of a Ruggedized AI-MS with
Remote Sampling for Explosives Trace
Detection; Mitch Wells; Mike Stump; Bruce
Solomon; Mark Gregory; Dennis Barket; FLIR Mass
Spectrometry, West Lafayette, IN
ThOA am 09:10 Microscopy Guided Atmospheric Ionization
in situ Top-Down Protein Mass Spectrometry;
Cheng-Chih Hsu1; Tiffany Poon2; Eugene C. Lin1;
Nick White2; Marito Hayashi2; Indroneal Banerjee3;
Ju Chen3; Samuel L. Pfaff2; Eduardo R. Macagno4;
Pieter C. Dorrestein1, 5; 1Department of Chemistry
and Biochemistry, UCSD, La Jolla, CA; 2Salk
Institute, La Jolla, CA; 3Department of Medicine,
UCSD, La Jolla, CA; 4Division of Biological
Sciences, UCSD, La Jolla, CA; 5Skaggs School of
Pharmacy, UCSD, La Jolla, CA
ThOA am 09:30 Embryonic Metabolic Status Evaluated BY
Combining DESI-HRMS Positive and Negative
Ion Mode Mass Spectral Data by Data Fusion
Strategy; Valentina Pirro1; Christina R. Ferreira2;
Paolo Oliveri3; Andres F. Gonzales-Serrano4; Livia
S. Eberlin2; Julia Heinzmann4; Andrea LucasHahn4; Heiner Niemann4; Robert G. Cooks2;
1
Università degli Studi di Torino, Torino, ITALY;
2
Department of Chemistry, Purdue University, West
Lafayette, Indiana; 3Department of Pharmacy,
University of Genova, Genova, Italy; 4Department
of Biotechnology, Friedrich-Loeffler-In, Neustadt,
Gernany
ThOA am 09:50 Combining Atomic Force Microscopy and
Thermal Desorption-Based Surface Sampling/
Ionization Mass Spectrometry for Submicrometer
Scale Multimodal Chemical Imaging; Olga S.
Ovchinnikova1; Kevin Kjoller2; Gary J. Van Berkel1;
1
Oak Ridge National Laboratory, Oak Ridge , TN;
2
Anasys Instruments, Santa Barbara, CA

PAGE 46					

ThOA am 10:10 Rapid Evaporative Ionization Mass Spectrometry
– Mechanism and Applications; Dániel Szalay1;
Lajos Gödörházy1; Tamás Karancsi1; Andor
Rozsnyai1; Ottmar Golf2; Karl-Christian Schäfer2;
Steven Pringle3; Mike Morris3; Zoltán Takáts2;
1
Medimass Ltd., Budapest, Hungary; 2Imperial
College London, London , UK; 3Waters Corporation,
Manchester, UK
8:30 – 10:30 AM, THURSDAY MORNING
METABOLOMICS
Lloyd Sumner (Samuel Roberts Noble Fndn), presiding
Room L100 (lower level)
ThOB am 08:30 Multivariate and Network Tools for Analysis
and Visualization of Metabolomic Data;
Dmitry Grapov1, 2; Oliver Fiehn1, 2; 1West Coast
Metabolomics Center, Davis, CA; 2University of
California, Davis, CA
ThOB am 08:50 A Novel Approach for Processing LC-Ion
Mobility-MS Metabolomics Data; Giorgis Isaac2;
Martin Palmer3; Mark Bennett1; James Langridge3;
John P. Shockcor2; Andy Borthwick1; 1Nonlinear
Dynamics, Newcastle, upon Tyne , UK; 2Waters
Corporations, Milford, MA; 3Waters Corporation,
Manchester, UK
ThOB am 09:10 High(er) Throughput Metabolite Annotation in
LC/MS Metabolomics; Steffen Neumann1; Michael
Gerlich1; Carsten Kuhl1; Andrea Thum2; Christoph
Böttcher1; 1Leibniz Institute of Plant Biochemistry,
Halle, Germany; 2Martin Luther Universität, Halle,
Germany
ThOB am 09:30 RAMClust: An Unsupervised Feature Clustering
Method for Non-Targeted Metabolomics
Datasets; Corey D. Broeckling; Fayyaz A. Afsar;
Asa Ben-Hur; Jessica E. Prenni; Colorado State
University, Fort Collins, CO
ThOB am 09:50 MRMPROBS: Data Assessment and Metabolite
Identification Tool for Large-scale MRM-based
Widely Targeted Metabolomics; Tsugawa Hiroshi1;
Arita Masanori1; Kanazawa Mitsuhiro3; Ogiwara
Atsushi3; Bamba Takeshi2; Fukusaki Eiichiro2;
1
RIKEN, Yokohama, Japan; 2Osaka University, Suita,
Japan; 3Reifycs, Inc., Minato-ku, Japan

61ST ASMS CONFERENCE ON MASS SPECTROMETRY

THURSDAY MORNING ORAL SESSIONS

ThOB am 10:10 Untargeted Metabolomics: From Statistical
Objects to the Efficient Identification of “Known
Unknowns”; Robert Mistrik; Juraj Lutisan;
HighChem, Bratislava, Slovakia
8:30 – 10:30 AM, THURSDAY MORNING
REGULATED BIOANALYSIS AND DIAGNOSTICS USING HIGH
RESOLUTION LC/MS
David Burinsky (Alcon Laboratories), presiding
Ballroom B
ThOC am 08:30 Balancing Sensitivity Gains and Method
Simplification: Investigating HR/AM and a
new Nanospray Source for a Challenging
Bioanalytical Method; Min Meng3; Hongxia Wang1;
Kate Comstock1; Spencer Carter2; Patrick Bennett1;
1
Thermo Fisher Scientific, San Jose, CA; 2WIL
Research, Ashland, OH; 3Tandem Labs, Salt Lake
City, UT
ThOC am 08:50 Monitoring Phosphodiesterase-4 Inhibitors using
LC-MS(/MS) in Sports Drug Testing; Mario Thevis1;
Oliver Krug2; Wilhelm Schänzer1; 1German Sport
University, Cologne, Germany; 2Europ. Monitoring
Center f. Emerging Doping Agents, Cologne/Bonn,
Germany
ThOC am 09:10 A Single Multi-Attribute Method for Quality
Control and Release Testing of Therapeutic
Biomolecules; Rich Rogers1; Brittney Livingston1;
Jenn Kerr1; Nancy Nightlinger1; Becky Scott1;
Sihong Deng1; Brittany Affholter1; David Bassett1;
Jim Bailey1; Steve Cockrill1; Quanzhou Luo1; Oleg
Borisov1; Bob Bailey1; Scott Peterman2; Amol
Prakash2; Hongxia Wang2; Kevin Wheeler2; Patrick
Bennett2; Alain Balland1; 1Amgen, Seattle, WA;
2
Thermofisher, San Jose, CA
ThOC am 09:30 Determination of Colistin Pharmacokinetics in
Human Plasma and Bronchoalveolar Lavage by
a Novel UPLC-ESI QTOF MS/MS Methodology;
Demetris Anagnostopoulos1; Evangelos Gikas1,
2
; Konstantinos Papanikolaou4; Panagiotis
Haritidis2; Athanassios Skoutelis3; George Daikos4;
Anthony Tsarbopoulos1, 5; 1The Goulandris Natural
History Museum, Kifissia, Greece; 2University of
Athens, Pharmacy Department, Athens, Greece;
3
Evangelismos Hospital, Dpt. of Internal Medicine,
Athens, Greece; 4University of Athens Medical
School, Internal Med., Athens, Greece; 5University
of Athens Medical School, Pharmacology, Athens,
Greece
ThOC am 09:50 Validation of a Glycan Biomarker Set for the
Detection of Ovarian Cancer using Mass
Spectrometry; L. Renee Ruhaak1; Sandra Taylor1;
Cynthia Williams1; UyenThao Nguyen1; Lauren
Dimapasoc1; Sureyya Ozcan1; Carol Stroble1,
2
; Suzanne Miyamoto2; Kyoungmi Kim1; Gary
Leiserowitz2; Carlito B. Lebrilla1; 1University of
California, Davis, CA; 2UC Davis Comprehensive
Cancer Center, Sacramento, CA
ThOC am 10:10 Quantification of Purine Biomarkers by
UPLC-MS/MS for Clinical Diagnostic of Rare
Kidney Stones and Kidney Failure; Margrét
Thorsteinsdóttir1, 2; Finnur Freyr Eiriksson1, 2; Vidar
O Edvardsson1, 3; Runolfur Palsson1, 3; 1University of
Iceland, Reykjavik , Iceland; 2ArcticMass, Reykjavík,
Iceland; 3Landspitali University Hospital, Reykjavik,
Iceland

8:30 – 10:30 AM, THURSDAY MORNING
DISEASE BIOMARKERS AND PATHWAYS
Carol Nilsson (UTMB), presiding
Ballroom A
ThOD am 08:30 Deciphering Breast Cancer Proteogenomics
using Bioinformatics Methods; Kelly V. Ruggles1;
Zuojian Tang1; Manor Askenazi2; Olexandra Ovsiy1;
Christopher Maher3; Li Ding3; Stuart Brown1; Steven
Shen1; Meera Prasad1; Jeremy Hoog3; Shunqiang
Li3; Robert T. Kitchens3; Charles M. Perou4; Sherri
R. Davies3; Matthew J. Ellis3; R. Reid Townsend 3;
David Fenyo1; 1NYU Langone Medical Center, New
York, NY; 2The Ionomix Initiative, Arlington, MA;
3
Washington University, St. Louis, MO; 4University of
North Carolina, Chapel Hill, NC
ThOD am 08:50 Proteomic Profiling of Breast Cancer Cell
Line Secretome for Basal-type Specific Tumor
Biomarker Discovery using Skyline MS1
Filtering; Anna M. Zawadzka; Birgit Schilling;
Michael P. Cusack; Christopher Benz; Bradford
W. Gibson; Buck Institute for Research on Aging,
Novato, CA
ThOD am 09:10 Comparative Proteome Analysis Reveals an
11-Protein Signature that Predicts Clinical
Outcome in Triple Negative Breast Cancer;
Ning Qing Liu1; Tommaso De Marchi1; Annemieke
M. Timmermans1; Christoph Stingl1; Anita M.A.C.
Trapman-Jansen1; Renée Foekens1; Maxime P.
Look1; Marcel Smid1; Carolien H.M. van Deurzen1;
René B.H. Braakman1; Paul N. Span2; Fred C.G.J.
Sweep2; Barbro K. Linderholm3; Anita Mangia4;
Angelo Paradiso4; Luc Y. Dirix5; Steven J. Van
Laere5; Julie Benedicte Brask6; Vera TimmermansWielenga6; Theo M. Luider1; John W.M. Martens1;
John A. Foekens1; Arzu Umar1; 1Erasmus University
Medical Center, Rotterdam, Netherlands; 2University
Nijmegen Medical Centre, Nijmegen, Netherlands;
3
Karolinska Institute, Stockholm, Sweden; 4National
Cancer Centre Giovanni Paolo II, Bari, Italy;
5
GZA hospitals St-Augustinus, Antwerp, Belgium;
6
Copenhagen University Hospital, Copenhagen,
Denmark
ThOD am 09:30 Targeting the Multi-Hit Mechanism of IgA
Nephropathy through Systematic Serum Analysis
of Circulating Components and Upstream
Effector’s; Jennifer Cushing1; Audra Hargett1; Stacy
Hall1; Blake P. Moore1; Greg Bowersock1; Monica W.
Stinnett1; Kazuo Takahashi1, 2; Hitoshi Suzuki1; Tyler
J. Stewart1; LeeAnn J. Boerma1; Scott Peterman3;
Amol Prakesh3; Milan Raska1; Jiri Mestecky1; Bruce
A. Julian1; Jan Novak1; Matthew B. Renfrow1;
1
University of Alabama at Birmingham, Birmingham,
AL; 2Fujita Health University School of Medicine,
Toyoake, Japan; 3ThermoFisher Scientific, San Jose,
CA
ThOD am 09:50 Cell Membrane Glycan Profiling Differentiates
Cancer Cell Origin and Molecular Subtype;
Serenus Hua1; Lauren Dimapasoc2; Bum Jin Kim1;
Seung Hyup Jeong1; Jae Han Kim1; Carlito Lebrilla2;
Hyun Joo An1; 1GRAST, Chungnam National
University, Daejeon, South Korea; 2University of
California, Davis, CA
ThOD am 10:10 Elucidating Pathways Associated with Sudden
Infant Death Syndrome (SIDS) using Quantitative
Proteomics to Analyze Various Regions Isolated
from Autopsied Brainstems; Kevin G. Broadbelt1,

61ST ASMS CONFERENCE ON MASS SPECTROMETRY						

PAGE 47

GENERAL
INFORMATION
THURSDAY
MORNING
ORAL SESSIONS

; Claire F. Magiotto2; Catherine A. Hassett2; Jan
Muntel1, 2; Elisabeth A. Haas3; Henry F. Krous3;
Hannah C. Kinney2; Hanno Steen1, 2; 1Proteomics
Center, Boston Children’s Hospital, Boston, MA;
2
Department of Pathology,Boston Children’s Hospital,
Boston, MA; 3Rady Children’s Hospital San Diego and
UCSD, San Diego School of Medicine, La Jolla, CA
2

8:30 – 10:30 AM, THURSDAY MORNING
SPACE SCIENCE, ASTROBIOLOGY, AND
ATMOSPHERIC CHEMISTRY
Veronica Bierbaum (University of Colorado), presiding
Auditorium
ThOE am 08:30 Micro-AirCore: Spatial Mapping of Atmospheric
Species; Kristin Favela1; Pieter Tans2; Thomas
Jaeckle1; William Williamson1; 1Southwest Research
Institute, San Antonio, TX; 2National Oceanic and
Atmospheric Administration, Boulder, CO
ThOE am 08:50 Development of a Dual Ion Source Linear Ion
Trap Mass Spectrometer for in situ Detection
of Organics on Mars; Ryan M. Danell1; Veronica
Pinnick2; Friso Van Amerom3; Ricardo Arevalo2;
Xiang Li2; William Brinckerhoff2; Paul Mahaffy2;
1
Danell Consulting, Inc., Winterville, NC; 2NASA
Goddard Space Flight Center, Greenbelt, MD; 3SRI
International, St Petersburg, FL
ThOE am 09:10 Cluster Ion Imaging of the ‘’Paris’’ Meteorite;
Manale Noun1, 2; Bilal Nsouli2; Donia Baklouti3;
Rosario Brunetto3; Frédéric Jamme4; Christophe
Sandt4; Paul Dumas4; Louis Hendecourt3; Serge
Della-Negra1; 1Institut de Physique Nucleaire d’Orsay,
Orsay Cedex, FRANCE; 2Lebanese Atomic Energy
Commission,CNRSL, Beirut, Lebanon; 3Institut
d’Astrophysique Spatiale, CNRS, UMR-8617, Orsay,
France; 4Synchrotron SOLEIL, Gif-sur-Yvette-France,
Orsay, France
ThOE am 09:30 Mass Spectrometric-based Investigations of
Polymerized Biomolecules Synthesized in
Miller’s Unreported Cyanamide Spark Discharge
Experiment; Eric Parker1; Manshui Zhou1; Aaron
Burton2; Daniel Glavin2; Jason Dworkin2; Facundo
Fernández1; Jeffrey Bada3; 1Georgia Institute of
Technology, Atlanta, U.S.A; 2NASA Goddard Space
Flight Center, Greenbelt, MD; 3Scripps Institution of
Oceanography, La Jolla, CA
ThOE am 09:50 Structural Determination of Titan’s Tholins
Components by Tandem FTMS, by Standard
Comparison and Action Spectroscopy; Roland
Thissen1; Arpad Somogyi2; Véronique Vuitton1;
Laurène Flandinet1; Anne Millet3; Carlos Perez del
Valle3; Istvan Komaromi4; 1IPAG, Grenoble, France;
2
University of Arizona, Tucson, AZ; 3Département
de Chimie Moléculaire, UJF, Grenoble, France;
4
University of Debrecen, Debrecen, Hungary
ThOE am 10:10 Polycyclic Aromatic Hydrocarbon Evolution in
a Nitrogen Environment Driven by Collisional
Activation, Cold Plasma Discharge, or UV
Radiation: A Tholin Study; Anyin Li1; Fred Jjunju2; R.
Graham Cooks1; 1Purdue University, West Lafayette,
IN; 2King Abdullah University of Science and
Technology, CEMSE KAUST, Thuwah, KSA

PAGE 48					

8:30 – 10:30 AM, THURSDAY MORNING
IMAGING MS: PHARMACEUTICAL APPLICATIONS
Walter Korfmacher (Genzyme), presiding
Room 101
ThOF am 08:30 Mass Spectrometry Imaging for Pharmaceutical
R&D Employing Cassette Drugs Dosing for Higher
Throughput High Resolution Pharmacokinetic
and Biodistribution Analysis; Richard Goodwin1;
John Swales1; Michael Rooney2; C. Logan Mackay3;
Per Andren4; Peter Webborn1; 1AstraZeneca, UK,
Macclesfield, UK; 2AstraZeneca, USA, Waltham, MA;
3
University of Edinburgh, Edinburgh, UK; 4Uppsala
University, Uppsala, Sweden
ThOF am 08:50 Label-Free Mass Spectrometry Imaging of Drug
and Metabolites in Target Tissue; Angela Wehr; Lin
Xu; Chandra Prakash; Biogen Idec, Cambridge, MA
ThOF am 09:10 Drug and Metabolism Studies using Infrared
Matrix-Assisted Laser Desorption Electrospray
Ionization Mass Spectrometry Imaging (IRMALDESI MSI) Coupled to FT-ICR MS; Jeremy A.
Barry1; Reid Groseclose2; Guillaume Robichaud1;
David Wagner2; Stephen Castellino2; David C.
Muddiman1; 1North Carolina State University, Raleigh,
NC; 2GlaxoSmithKline, Research Triangle Park, NC
ThOF am 09:30 Muscarinic Receptor Antagonist Target
Disposition in Lung Disease Utilizing 10-µm
Spatial Resolution of AP SMALDI Tissue Imaging;
Akos Vegvari1; Kerstin Strupat3; Magnus Dahlbäck2;
Thomas Fehniger1; György Marko-Varga1; 1Lund
University, Lund, Sweden; 2Astra Zeneca R&D,
Mölndal, Sweden; 3Thermo Fisher Scientific (Bremen)
GmbH, Bremen, Germany
ThOF am 09:50 MALDI-MS Imaging and Quantitation of Primary
Amine Neurotransmitters Dopamine, GABA and
Glutamate Directly in Brain Tissue Sections;
Mohammadreza Shariatgorji1; Anna Nilsson1; Richard
Goodwin1; Xiaoqun Zhang2; Nicoletta Schintu2; Per
Svenningsson2; Per E. Andren1; 1Uppsala University,
Uppsala, Sweden; 2Karolinska Institutet, Stockholm,
Sweden
ThOF am 10:10 Evaluation of Quantitative MSI Approaches
Applied to Small and Large Molecules Analysis in
tissue; Gregory Hamm; Guillaume Hochart; Fabien
Pamelard; raphael legouffe; David Bonnel; Jonathan
Stauber; ImaBiotech, MS Imaging Department, Lille,
France
8:30 – 10:30 AM, THURSDAY MORNING
ENERGY, PETROLEUM, AND BIOFUELS: ADVANCES IN MS
DESIGN AND INFORMATICS
Steven Kass (University of Minnesota), presiding
Room 102
ThOG am 08:30 Ultra-Fast, High Mass-Resolution Multi-ReflectionTime-of-Flight-Mass Spectrometer as Detector
for One-Dimensional and Comprehensive
Two-Dimensional Gas Chromatography:
Characterization of Highly Complex
Petrochemical Mixtures; Ralf Zimmermann1, 2;
Thomas Gröger1; Jürgen Wendt3; 1JMSC, CMA
Helmholtz Zentrum Muenchen,, Neuherberg, ,
Germany; 2JMSC, Analytical Chemistry, University of
Rostock, Rostock, Germany; 3LECO European LSCA
Centre, Moenchengladbach, Germany

61ST ASMS CONFERENCE ON MASS SPECTROMETRY

THURSDAY MORNING ORAL SESSIONS

ThOG am 08:50 Validation of High Resolution Time-ofFlight Petroleomics: Linearity, Repeatability,
and Accuracy of Hetereoatomic Species
Measurements in Crude Petroleum; Clécio F.
Klitzke1; Kevin Siek2; Julie A.B. Hernández3; Rubens
Maciel-Filho3; Marcos N. Eberlin1; Joe Binkley2;
Jeffrey S. Patrick2; Wibke Peters4; 1UNICAMP.
Institute of Chemistry, Campinas, Brazil; 2LECO
Corporation, St. Joseph, MI; 3UNICAMP. Chemical
Engineering Faculty, Campinas, Brazil; 4LECO
Instrumente GmbH, Mönchengladbach, Germany
ThOG am 09:10 A New Apparatus for Study of PressureDependent Laminar Premixed Flames with VUV
Photoionization Mass Spectrometry; Zhongyue
Zhou; Yu Wang; Xiaofeng Tang; Wuhua Wu; Fei Qi;
University of Science and Technology of China, Hefei,
China
ThOG am 09:30 Analysis of Hydrocarbon Based Oil from
Hydrothermal Treatment of Algal Biomass by
Complementary 2D GC and ESI-FTICR-MS;
Wassim Obeid; Patrick Hatcher; Old Dominion
University, Norfolk, VA
ThOG am 09:50 Climate Change Effects on Biomass Emissions
and Biofuels; Simin Maleknia 1; Andreas Klingberg2;
Juergen Odermatt2; 1University of New South Wales,
Sydney , Australia; 2Institute for Wood Chemistry,
Hamburg, Germany
ThOG am 10:10 Characterization of Organosolv Switchgrass
by High Performance Liquid Chromatography/
High Resolution Multiple Stage Tandem
Mass Spectrometry Using Hydroxide-Doped
Electrospray Ionization; Tiffany Jarrell1; Christopher
Marcum1; Benjamin Owen1; Joseph Bozell2; Hilkka
Kenttämaa1; 1Purdue University, Lafayette, IN;
2
University of Tennessee, Knoxville, TN

8:30 – 10:30 AM, THURSDAY MORNING
EPIGENETIC MODIFICATIONS AND MECHANISMS
Ben Garcia (University of Pennsylvania), presiding
Room 103
ThOH am 08:30 Mass Spectrometry Based Quantification of
Epigenetic DNA Modifications in vivo; Delshanee
Kotandeniya; Brock Matter; Jungmin Song; Xuemin
Qian; Fekadu Kassie; Natalia Tretyakova; University
of Minnesota, Minneapolis, MN
ThOH am 08:50 Toward Solving the Histone Code: A Novel
Method to Identify Histone PTM Crosstalk using
Quantitative Mass Spectrometry; Yael David1; Anna
Arnaudo2; Tom Muir1; 1Princeton University, Princeton,
NJ; 2University of Pennsylvania, Philadelphia, PA
ThOH am 09:10 RapidFire MS/MS Enables Both Rapid Evaluation
of Multiple Histone Methyltransferases and LabelFree High Throughput Screening of Targeted
Compound Libraries; Patrick Bingham; Cody
Krivacic; Dawn Nowlin; Karen Maegley; Pfizer, San
Diego, CA
ThOH am 09:30 The Functional Interactome Landscape of
the Human Histone Deacetylase Family: A
Proteomics-Bioinformatics Approach for Profiling
Relative Interaction Stabilities; Preeti Joshi1; Todd
Greco1; Amanda Guise1; Yang Luo1; Fang Yu1; Alexey
Nesvizhskii2; Ileana M. Cristea1; 1Princeton University,
Princeton, NJ; 2University of Michigan Medical
School, Ann Arbor, MI
ThOH am 09:50 Comprehensive Maps of Ribonucleotide
Modifications as Possible Indicators of Cell
Identity, Epigenetic, and Metabolic State; Rebecca
E. Rose; Ryan Quinn; D. Fabris; The RNA Institute,
University at Albany, Albany, NY
ThOH am 10:10 MS-based Measurement and Modeling of Histone
Methylation Kinetics (M4K) in Multiple Myeloma
Cells Carrying Methyltransferase Mutations;
Yupeng Zheng1; Nir Yungster1; Relja Popovic2;
Teresa Ezponda-Itoiz2; Paul Thomas1; Jonathan
Licht2; William Kath1; Neil Kelleher1, 2; 1Northwestern
Univeristy, Evanston, IL; 2Feinberg School of
Medicine, Northwestern Univ, Chicago, IL

10:30 AM - 2:30 PM
THURSDAY POSTER SESSION
Exhibit Hall BC
Lunch concessions are open 11:00 am - 2:00 pm

61ST ASMS CONFERENCE ON MASS SPECTROMETRY						

PAGE 49

GENERAL
INFORMATION
THURSDAY
AFTERNOON
ORAL SESSIONS

2:30 – 4:30 PM, THURSDAY AFTERNOON
AMBIENT AND ATMOSPHERIC PRESSURE IONIZATION:
FUNDAMENTALS
Gary Van Berkel (Oak Ridge National Laboratory), presiding
Exhibit Hall A
ThOA pm 2:30 Dissociative Electron Transfer Desorption: A
Non-Thermal Desorption Mechanism in PlasmaBased Ambient Ionization; Joshua Wiley; Jacob
Shelley; Jobin Cyriac; Graham Cooks; Purdue
University, West Lafayette, IN
ThOA pm 2:50 A New Ambient Ionization Method for Ionization
of Volatile and Nonvolatile Compounds;
Shubhashis Chakrabarty; Vincent S. Pagnotti;
Charles N. McEwen; University of the Sciences,
Philadelphia, PA
ThOA pm 3:10 Visualization of Mass Transfer in the Flowing
Atmospheric-Pressure Afterglow Source
for Ambient Desorption/Ionization Mass
Spectrometry; Kevin Pfeuffer; Steven Ray; Gary
Hieftje; Indiana University, Bloomington, IN
ThOA pm 3:30 Sorting Surface Affinity of Analytes in Droplets
by Pulsed Nanospray Ionization; Carina Minardi;
Haopeng Wang; Kaveh Jorabchi; Georgetown Univ.,
Washington, DC
ThOA pm 3:50 Elucidation of Reagent Species and Mechanisms
in the Direct Sampling Analysis (DSA) Source;
Sharanya Reddy; Thomas White; George Perkins;
Craig Whitehouse; PerkinElmer, Shelton, CT
ThOA pm 4:10 Development of Atmospheric Pressure Laser
Ionization Method using a Novel 6 µm-Band MidInfrared Tunable Laser and Solvent as Matrix;
Ryuji Hiraguchi; Hisanao Hazama; Kunio Awazu;
Osaka University, Suita, Japan
2:30 – 4:30 PM, THURSDAY AFTERNOON
PROTEOMICS: INFECTIONS DISEASES
Mark E. Bier (Carnegie Mellon University), presiding
Room L100
ThOB pm 2:30 Neutron-Encoded (NeuCode) Mass Signatures
for the Absolute Quantification of Vesicular
Stomatitis Virus Proteins during Infection;
Gregory K. Potts; Emily A. Voigt; John Yin; Joshua J.
Coon; University of Wisconsin, Madison, WI
ThOB pm 2:50 Probing the Hijacking of the Dynamic Epigenome
during Viral Infection; Benjamin Garcia1; Peter
DiMaggio2; Christine O’Connor4; Tom Shenk3;
1
University of Pennsylvania, Philadelphia, PA;
2
Imperial College, London, UK; 3Princeton University,
Princeton, NJ; 4Cleveland Clinic, Cleveland, OH
ThOB pm 3:10 Defining the HIV-1 Interactome using Insertional
Mutagenesis Tagging and I-DIRT; Yang Luo2;
Erica Jacobs1; Todd Greco3; Sarah Keegan4; David
Fenyö4; Michael Rout1; Ileana Cristea3; Mark
Muesing2; Brian Chait1; 1Rockefeller University, New
York, NY; 2Aaron Diamond Aids Research Center,
New York, NY; 3Princeton University, Princeton, NJ;
4
New York University, New York, NY
ThOB pm 3:30 Combining Fragmentation Data with an
Interactive de novo Sequencing Program to
Characterize Circulating Antibodies against
Malaria, Jessica Chapman1; Wilfred Tang2; Yong
Kil2; Chris Becker2; Marshall Bern2; David Fenyo1;
Matthias Muellenbeck3; Hedda Wardemann3; Beatrix
Ueberheide1; 1New York University Langone Medical

PAGE 50					

Center, New York, NY; 2Protein Metrics, San Carlos,
CA; 3Max Planck Institute for Infection Biology,
Berlin, Germany
ThOB pm 3:50 Exploring Neisseria meningitidis Virulence with
Top-Down Mass Spectrometry; Joseph Gault1;
Christian Malosse4; Marie-Cécile Ploy5; Catherine E.
Costello2; Guillaume Duménil3; Julia Chamot-Rooke4;
1
Institut Pasteur, Paris, France; 2Boston University
School of Medicine, Boston, MA; 3Hôpital Européen
G. Pompidou, INSERM, Paris, France; 4Institut
Pasteur, CNRS, Paris, France; 5CHU Limoges,
INSERM, Limoges, France
ThOB pm 4:10 A Systems Biology Approach for the Discovery
of Drug and/or Vaccine Targets in Plasmodium
falciparum using Irradiated Long-Lived
Merozoites; Krishan Kumar1; Prakash Srinivasan2;
Michael J. Nold3; Dan Sturdevant4; J. Kathleen
Moch5; Karine Reiter1; Steve F. Porcella4; Scott
Geromanos3; Julian C. Rayner6; J. David Haynes5;
David L. Narum1; 1LMIV,NIAID,NIH, Rockville,
MD; 2LMVR,NIAID,NIH, Rockville, MD; 3Waters
Corporation, Milford, MA; 4RTB, NIAID, NIH,
Hamilton, MT; 5Walter Reed Army Institute of
Research, Silver Spring, MD; 6Wellcome Trust
Sanger Institute, Hinxton, Cambridge, UK
2:30 – 4:30 PM, THURSDAY AFTERNOON
LIPIDS AND PROFILING
David Goodlett (University of Maryland), presiding
Ballroom B
ThOC pm 2:30 Novel Application of Reversed-Phase UHPLC–
QTOFMS for Comprehensive Analysis of Plasma
Lipids; Tomas Cajka; William Wikoff; Carlos Leon;
Brian DeFelice; Dmitry Grapov; Oliver Fiehn;
University of California, Davis, CA
ThOC pm 2:50 Lipidomic Profiling of Commensal Microbe
Bacteroides Fragilis And Identification of
Immunomodulatory Sphingolipids; Sungwhan
Oh; Dingding An; Fikri Avci; Dennis Kasper; Harvard
Medical School, Boston, MA
ThOC pm 3:10 High-Throughput Lipid Profiling System for Dried
Plasma Spots using Online-Supercritical Fluid
Extraction-Supercritical Fluid Chromatography/
Mass Spectrometry; Takeshi Bamba; Takato
Uchikata; Atsuki Matsubara; Eiichiro Fukusaki; Dept.
Biotech., Grad. Sch. Eng., Osaka Univ., Suita, Japan
ThOC pm 3:30 Gas-Phase Transformation of
Phosphatidylcholine Cations to Structurally
Informative Anions via Ion/Ion Chemistry; John
Stutzman1; Stephen Blanksby2; Scott McLuckey1;
1
Purdue University, West Lafayette, IN; 2University of
Wollongong, Wollongong, Australia
ThOC pm 3:50 Long-Term Performance and Stability of Shotgun
Lipidomic Analysis of Human Plasma Samples;
Laura Heiskanen; Kirill Tarasov; Hung Xuan Ta;
Tuulia Sylvänne; Helena Simolin; Dimple Kauhanen;
Kim Ekroos; Zora Biosciences Oy, Espoo, Finland
ThOC pm 4:10 Nanomanipulation-Coupled to Mass
Spectrometry for Direct Organelle Analysis to
Explore Lipid Localization Chemistry within
Single Cells; Kristina Clemons1; Sheida Torabi2;
Huanbiao Mo2; Guido Verbeck1; 1Univ. of North
Texas, Denton, TX; 2Texas Women’s University,
Denton, TX

61ST ASMS CONFERENCE ON MASS SPECTROMETRY

THURSDAY AFTERNOON ORAL SESSIONS

2:30 – 4:30 PM, THURSDAY AFTERNOON
BIOMARKERS IN DRUG DISCOVERY AND DEVELOPMENT
Chandra Prakash (Biogen Idec), presiding
Ballroom A
ThOD pm 2:30 Challenges and Considerations for Multicomponent LCMS Biomarker Assays:
Lysophosphatidic Acids as Biomarkers; Petia
Shipkova; Joelle Onorato; Michael Furlong; Anne
Minnich; Bristol Myers Squibb, Princeton, NJ
ThOD pm 2:50 LC-MS Strategies for Separation and Detection
of Endogenous Organic Acids and Polar
Metabolites in Pharmaceutical R&D; David
Pirman; Matthew Blatnik; Pfizer, Groton, CT
ThOD pm 3:10 The “Off Targets” of Angiotensin Converting
Enzyme – A Peptidomic Approach; Teresa B.
Hong1; Gabriel B Gugiu1; Tea Janjulia2; Kenneth E.
Bernstein2; Markus Kalkum1; 1City of Hope, Duarte,
CA; 2Cedars-Sinai Medical Center, Los Angeles, CA
ThOD pm 3:30 LC/SRM Reveals Amyloid-Beta Isoforms’
Metabolic Differences and Diurnal Fluctuations in
Alzheimer’s Disease; Kwasi Mawuenyega; Vitaliy
Ovod; Tom Kasten; Yafei Huang; Wendy Sigurdson;
Randall Bateman; Washington University School of
Medicine, Saint Louis, MO
ThOD pm 3:50 Using Mass Spectrometry to Identify a Novel
Protein Responsible for Adrenal Amyloidosis;
Stephanie M. Cologna; Mitra L. Rauschecker; Peter
S. Backlund; Robert D. Shamburek; James E. Balow;
Alfred L. Yergey; Constantine A. Stratakis; Smita B.
Abraham; National Institutes of Health, Bethesda,
MD
ThOD pm 4:10 Development and Qualification of a Multiplexed
Selected Reaction Monitoring-Mass Spectrometry
Based Assay for Evaluation of Candidate
Alzheimer’s Disease Progression Markers; Daniel
S. Spellman1; Weixun Wang1; Katie Southwick2;
Rachel Korn1; Ronald A. Miller1; Mary J. Savage1;
Daniel J. Holder1; Nathan A. Yates3; Ronald C.
Hendrickson4; Bonnie J. Howell1; 1Merck and Co.,
Inc., West Point, PA; 2Thermo Fisher Scientific, San
Jose, CA; 3University of Pittsburgh, Pittsburgh, PA;
4
Memorial Sloan-Kettering Cancer Center, New York, NY
2:30 – 4:30 PM, THURSDAY AFTERNOON
PLANT”OMICS”
Michelle Cilia (US Department of Agriculture), presiding
Auditorium
ThOE pm 2:30 An Overview of Label-Free Quantitative
Shotgun Proteomics in Rice and Grapevines;
Paul A. Haynes1; Karlie Neilson1; Mehdi Mirzaei1;
Iniga George1; Shila Shabhazian1; C. Gayani
Gammulla1; Steve Van Sluyter1; Brian Atwell1; G.
Hosseini Salekdeh2; Anne Fennell3; Grant Cramer4;
1
Macquarie University, North Ryde, Sydney,
Australia; 2Agricultural Biotechnology Institute of
Iran, Tehran, Iran; 3South Dakota State University,
Brookings, SD; 4University of Nevada, Reno, NV
ThOE pm 2:50 Integrating the Malting Barley Metabolome,
Phenome and Genome using a Novel NonTargeted UPLC-MS Metabolomics Workflow;
Adam Heuberger1; Corey Broeckling1; Kaylyn
Kirkpatrick1; Gary Hanning2; Jessica Prenni1;
1
Colorado State University, Fort Collins, CO;
2
Anheuser-Busch, Inc., St. Louis, MO

ThOE pm 3:10 Improving the Identification Rate of Data
Independent Label-Free Quantitative Analysis: A
Proteomics Case Study on Apple Fruit; Kim Buts1;
Sebastien Carpentier2, 3; Servaas Michielssens4;
Eisuke Hayakawa5; Maarten Hertog1; Bart Nicolaï1;
1
BIOSYST-MeBioS, KULeuven, Heverlee, Belgium;
2
SYBIOMA, KULeuven, Leuven, Belgium; 3BIOSYSTCrop biotechnics, KU Leuven, Heverlee, Belgium;
4
Quantum and Physical Chemistry Section,
KULeuven, Heverlee, Belgium; 5Research Group
of Functional Genomics & Proteomics, Leuven,
Belgium
ThOE pm 3:30 A Novel GC/quadrupole-Orbitrap for Untargeted
Metabolomics and Combined Multi-Omics
Analysis of Symbiosis in Medicago Truncatula;
Allison J. Balloon1; Amelia C. Peterson2; Jens GriepRaming2; Christopher M. Rose1; Benjamin Minkoff1;
Muthusubramanian Venkateshwara1; Jeremy
Volkening1; Derek J. Bailey1; Paul A. Grimsrud1;
Junko Maeda1; Michael S. Westphall1; Michael R.
Sussman1; Jean-Michel Ané1; Joshua J. Coon1;
1
The University of Wisconsin, Madison, WI; 2Thermo
Fisher Scienfitic, Bremen, Germany
ThOE pm 3:50 Dissect Snf1-Related Protein Kinases (SnRKs)
Signaling Network in the Abscisic Acid (ABA)
Pathway-based on Kinase Assay Linked
Phosphoproteomics; Liang Xue1; Pengcheng
Wang2; Jian-kang Zhu2; W. Andy Tao1; 1Biochemistry,
Purdue University, West Lafayette, IN; 2Horticulture
& Landscape Architecture, Purdue Univ, West
Lafayette, IN
ThOE pm 4:10 Using Formaldehyde Crosslinking and LabelFree LC/MS/MS Quantification to Develop an LRR
RLK Interactome in Arabidopsis thaliana; Tara
Nash; Kevin Blackburn; Steven Clouse; Michael B.
Goshe; North Carolina State University, Raleigh, NC
2:30 – 4:30 PM, THURSDAY AFTERNOON
POLYMER-AND PACKAGING-RELATED CONTAMINANTS AND
DEGRADANTS IN FOOD, DRUGS, AND
CONSUMER PRODUCTS
David Stranz (Sierra Analytics, Inc.) and Luke Ackerman (FDA
Center for Food Safety), presiding
Room 101
ThOF pm 2:30 Migration and Identification of Leachables from
Drug Product Container Closure Systems; Case
Studies; Alan Hendricker; James Mclean; Thomas
Feinberg; Catalent Pharma Solutions, Morrisville, NC
ThOF pm 2:50 Analysis of Thermoplastic Copolymers by Mild
Thermal Degradation Coupled to Ion Mobility
Mass Spectrometry; Nadrah Alawani; Chrys
Wesdemiotis; The University of Akron, Akron, OH
ThOF pm 3:10 Transformation Products of Packaging Additives
as Leachables in Ophthalmic Drug Products;
Christopher Houston; Bausch & Lomb, Rochester,
NY
ThOF pm 3:30 Leachable and Extractable Analysis of IV Bag by
HR-LCMS, GCMS, and ICPMS , Kate Comstock;
Ekong Bassey; John Schmelzel; Thermo Fisher
Scientific, San Jose, CA
ThOF pm 3:50 Determination of Ultra Low Level Leachable
Components from Permanent Implantable
Medical Devices, Using Stir Bar Sorptive
Extraction and GC-MS/MS Detection; Gyorgy
Vas; Barbara Armstrong; Lori Alquier; Johnson and
Johnson Company, Raritan, NJ

61ST ASMS CONFERENCE ON MASS SPECTROMETRY						

PAGE 51

THURSDAY
AFTERNOON
ORAL SESSIONS
GENERAL
INFORMATION

ThOF pm 4:10 The Composition of d-α-Tocopheryl Polythylene
Glycol Succinate: A Different View from FTICR
Tandem MS; Juan Wei1; Anthony Bristow2; Eileen
McBride2; Peter O’Connor1; 1University fo warwick,
Coventry, UK; 2AstraZeneca UK Limited, London, UK
2:30 – 4:30 PM, THURSDAY AFTERNOON
ENERGY, PETROLEUM, AND BIOFUELS: ADVANCES IN SAMPLE
PREPARATION AND MS INTERFACE DESIGN
Michael McGinley (Phenomenex), presiding
Room 102
ThOG pm 2:30 Novel Analytical Methods for the On-Line
Analysis of the Primary Products of Fast
Pyrolysis of Cellulose and their Manipulation;
Matthew Hurt; John Degenstein; Piotr Gamecki;
David Borton; Nelson Vinueza; Rakesh Agrawal;
Nicholas Delgass; Fabio Ribeiro; Hilkka Kenttamaa;
Purdue University, West Lafayette, IN
ThOG pm 2:50 Pyrolysis and Reactive Pyrolysis GCMS
Investigation of Intractable Deposits and Spent
Catalysts; Michael T. Cheng; Chevron Research,
Richmond, CA
ThOG pm 3:10 A High Resolution Mass Spectrometry Platform
for Studying Kinetics of Biomass Pyrolysis:
Single Particle Pyrolysis Utilizing µPy-APCI-TOF;
Erica Smith; Carolyn Hutchinson; D. Paul Cole;
Young-Jin Lee; Chemistry Department, Iowa State
University, Ames, IA
ThOG pm 3:30 Chemical Characterization and Molecular
Weight Distribution from Distillation Products
of Colombian Crude Oils by MALDI TOF-TOF;
Enrique Mejía Ospino1; Rafael Cabanzo1; Diana
Catalina Palacio Lozano1; Jorge Armando Orrego2;
Neisy Calderon1; 1Universidad Industrial de
Santander, Bucaramanga, Colombia; 2Ecopetrol,
Bucaramanga, Colombia
ThOG pm 3:50 Structural Diversity of Petroporphyrins Isolated
from Natural Petroleum Seeps and Weathered Oil
by FT-ICR MS; Amy Mckenna1; Christoph Aeppli2;
David Valentine3; Huan Chen1; Ryan Rodgers1;
Robert nelson2; David Podgorski1; Karin Lemkau2;
Christopher Reddy2; Steven Rowland1; Winston
Robbins1; Alan Marshall1; Nathan Kaiser1; 1Natl High
Magnetic Field Laboratory, Tallahassee, FL; 2Woods
Hole Oceanographic Institute, Woods Hole, MA;
3
University of California, Santa Barbara, CA

2:30 – 4:30 PM, THURSDAY AFTERNOON
HISTORY:
CELEBRATION OF 100TH ANNIVERSARY OF
MASS SPECTROMETRY
Mike Grayson, presiding
Room 103
ThOH pm 2:30 Mass Spectrometry in Russia: From Static
Instruments to Electrospray; Lidia Gall; Institute of
Analytical Instrumentation, Saint Petersburg, Russia
ThOH pm 2:50 More than 100 years of Mass Spectrometry
– Developments in Germany; Simone Koenig;
University of Muenster, Muenster, Germany
ThOH pm 4:10 The More than Sixty-Year History of Mass
Spectrometry in Japan; Yoshinao Wada; Osaka
MCHRI / Osaka University, Osaka, Japan
ThOH pm 4:30 J.J. Thomson, Kenneth Bainbridge, and Special
Relativity; Robert K. Boyd; National Research
Council, Vancouver, Canada
ThOH pm 4:50 Promoters as Catalysts of the Advance of Mass
Spectrometry; Keith Nier
ThOH pm 5:10 The Crucial Roles of Mass Spectrometry in the
Manhattan Project; Keith Nier1; A. Karl Yergey2;
Alfred L. Yergey 3; 1Independent, Madison, NJ;
2
Educator, Hagerstown, MD; 3NIH, Bethesda, MD
4:45 - 5:30 PM, THURSDAY
PLENARY LECTURE
Jenny Brodbelt (University of Texas), presiding
Exhibit Hall A, Lower Level
Discovery of the Elusive Higgs Boson
Peter Onyisi
University of Texas at Austin

5:45 - 9:00 PM, THURSDAY AFTERNOON
TIME TO CELEBRATE
CLOSING GALA (ticket required)
FOOD, CASH BAR, FUN AND GAMES
Exhibit Hall D

ThOG pm 4:10 Studying Crude Oil Samples with Normal-Phase
HPLC Coupled to Atmospheric Pressure Laser
Ionization FT-ICR MS: Selective Analysis of
Nitrogen Compounds; Wolfgang Schrader1; Sami
Lababidi1; Saroj Panda1; Jan T. Andersson2; 1MaxPlanck Inst für Kohlenforschung., Mülheim / Ruhr,
Germany; 2University Münster, Münster, Germany

PAGE 52					

61ST ASMS CONFERENCE ON MASS SPECTROMETRY

MONDAY POSTERS

7:30 - 8:00 am.............................................. Set up all Monday posters
10:30 am - 1:00 pm..............................Odd-numbered posters present
12:00 - 2:30 pm.................................. Even-numbered posters present
7:30 - 8:00 pm........................................... Remove all Monday posters
Small Molecules: Quantitative Analysis I...................................001-030
Drug Metabolism: High Throughput Analysis,...........................031-040
Metabolomics: Identification of Unknown Metabolites...............041-059
Metabolomics: Untargeted Metabolite Profiling (Methods)........060-080
Metabolomics: Sample Preparation..........................................081-084
LC-MS: Chromatography..........................................................085-130
LC-MS: Sample Preparation (Small Molecules)........................131-150
MALDI Sample Preparation.......................................................151-167
Diagnostic Clinical Chemistry: Peptides/Proteins......................168-182
Imaging MS: Disease Markers..................................................183-206
Lipids General...........................................................................207-220
Lipids: Identification and Structural Analysis.............................221-232
Nucleic Acids: General..............................................................233-250
Nucleic Acids: RNA....................................................................251-262
Instrumentation: New Developments in Ionization and
Sampling...........................................................................263-293

These posters will be displayed Monday through Thursday
Museum From Radio Tube Cathodes to Cells in Mitosis: The
Evolution of Secondary Ion Mass Spectrometry (SIMS)
Instrumentation and Applications; P. Jane Gale1; Bryan
L. Bentz2; 1Gale-Bentz Consulting, Southborough, MA;
2
Waters Corporation, Milford, MA
Special 2013 Ron Hites Award Recipient: First Combination
of an Inductively Coupled Plasma Ion Source with
Distance-of-Flight Mass Spectrometry (ICP-DOFMS);
Alexander Gundlach-Graham1; Elise A. Dennis1; Steven
J. Ray1; Christie G. Enke2; Charles J Barinaga3; David
Koppenaal3; Gary Hieftje1; 1Indiana University, Bloomington,
IN; 2Department of Chemistry, University of New Mexico,
Albuquerque, NM; 3Pacific Northwest National Laboratory,
Richland, WA
Special Ability of the Glycoproteomics Comminuty to Profile
N-glycosylation of Prostate Specific Antigen by Mass
Spectrometry: An ABRF 2013 Interlaboratory Study;
Nancy Leymarie 1; Paula Griffin1; Chuanhua Xing1;
Karen Jonscher2; Daniel Kolarich3; Ron Orlando4; Mark
Mccomb1; Joseph Zaia1; 1CBMS, Boston University School
Medicine, Boston, MA; 2Dept of Anesthesiology University
of Colorado, Denver Aurora, CO; 3Max Planck Institute
of Colloids and Interfaces, Berlin, Germany; 4CCRC,
University of Georgia, Athens, GA
Small Molecules: Quantitative Analysis I, 001 - 030
MP 001

MP 002

MP 003

Lithium Adduct as Precursor Ion for Sensitive and
Rapid Quantification of 20 (S)-protopanaxadiol in Rat
Plasma by LC-MS/MS; Yuanwu Bao1; Pingming Tang2;
1
Sundia MediTech Company Ltd., Shanghai, China;
2
Suzhou Kangrun Pharmaceutical Testing Service, Inc,
Suzhou, China
An Isomeric Impurity Caused Bioanalytical Data
Discrepancy between +ESI and –ESI LC-MS/MS
Quantification of a Drug Discovery Compound; Guifen
Xu; Tom Huang; Thuy Tran; Qiuping Ye; Lixia Jin; Timothy
Carlson; Amgen, South San Francisco, CA
Development of a Method for Evaluation of Mass
Spectrometer Performance in Real Time; Terry Olney;
Huy Nguyen; Oleg Silivra; Thermo Fisher Scientific, San
Jose, CA

Instrumentation: New Developments in Mass Analyzers..........294-329
Ambient Ionization: Instrumentation..........................................330-356
Informatics: General..................................................................357-373
Informatics: Workflow and Data Management...........................374-386
Informatics: Crosslinking and Structure Analysis......................387-392
Crosslinking...............................................................................393-412
H/D Exchange: Protein Structure/Function...............................413-440
Proteins: General......................................................................441-462
New Advances in Quantitative Proteomics................................463-493
Protein Therapeutics: Quantitative Analysis..............................494-521
Biomarker Quantitation: Proteins and Peptides........................522-549
Biomarker Discovery: Cancer....................................................550-567
Immunology...............................................................................568-575
Molecular Systems Biology and Disease..................................576-603
Forensics...................................................................................604-628
Environmental Analysis: General I............................................629-652
Plant”omics”..............................................................................653-671
Agriculture.................................................................................672-682
Natural Products........................................................................683-714
Astrobiology & Atmospheric Chemistry.....................................715-720
Polymers...................................................................................721-749

MP 004

MP 005

MP 006

MP 007

MP 008

MP 009

MP 010

MP 011

MP 012

MP 013

A Quantitative Inspection of ESI Glucuronide
Degradation; Jeffrey R. Enders; Cade Park; Ayodele
Morris; Gregory McIntire; Ameritox, Ltd., Greensboro, NC
Oxidation of Analytes during Positive Ion Electrospray
Mass Spectrometric Analysis; Luis Sojo; Navjot Chahal;
Xenon Pharmaceutical, Burnaby, Canada
Using Synthetic Sample Matrices to Optimize Ion
Source Parameters and Evaluate Nozzle Geometry for
Improved Quantitative Analysis of Small Molecules;
Craig Love; Alex Mordehai; Agilent Technologies, Inc, Santa
Clara, CA
Mass Spectrometric Analysis of Retinoid Binding
Protein Receptor Substrate Specificity; Riki Kawaguchi1;
Ming Zhong2; Hui Sun2; 1UCLA Physiology, Los Angeles, CA;
2
Howard Hughes Medical Institute, UCLA, Los Angeles, CA
Impact of Immunosuppressant Interactions in LC-MS/
MS Analysis; Josh Cooper; Beth Marek; Isil Dilek; Uma
Sreenivasan; Cerilliant, Round Rock, TX
Secondary Crosstalk Case Report for Amprenavir and
Darunavir in the LC-MS/MS Quantification Method of
15 Anti-retroviral Drugs Measured Simultaneously;
Denis Thibeault; Rose Djiana; David Blank; Royal-Victoria
Hospital, Montreal, Canada
Novel High-Throughput Bioanalysis for Basic Drug
Candidates Formulated in PEG; Ling Xu; Shaoxia Yu;
Jing-Tao Wu; Millenniu30 Pharmaceutical, Cambridge, MA
Development and Validation of Methods for
Chemotherapy Drugs on the New Prelude SPLC TM LCMS/MS System; Kerry Hassell; Dayana Argoti; Sarah Fair;
Joseph Herman; ThermoFisher Scientific, Franklin, MA
Validated Ultra-trace Quantification Method for
Estrogens in Human Cerebrospinal Fluid using Bulk
Derivatization and Restricted Access Media with LCMS/MS; Hui Fan1; Barbora Papoušková2; Jane Wigginton3;
Karel Lemr2; Kevin Schug1; 1University of Texas Arlington,
Arlington, TX; 2Palacký University, Olomouc, Czech
Republic; 3University of Texas Southwestern Medical
School, Dallas, TX
Expanding the Linear Dynamic Range for Quantitative
Liquid chromatography-High Resolution Mass
Spectrometry Utilizing NaturalIsotopologue Signals;
Hanghui Liu1; Bert Chi1; Lily Lam1; Lin Yan1; Purnendu
Dasgupta2; 1Senomyx, San Diego, CA; 2Dept of Chem &
Biochem, UT Arlington, Arlington, TX

61ST ASMS CONFERENCE ON MASS SPECTROMETRY						

PAGE 53

MONDAY
POSTERS
GENERAL
INFORMATION

MP 014

MP 015

MP 016

MP 017

MP 018

MP 019

MP 020

MP 021

MP 022

MP 023

MP 024

MP 025

MP 026

MP 027

Investigation on Internal Standard Response Variability
during LCMSMS Analysis of Fesoterodine; Nicolas
Jean; Marie-Claude Théberge; Sylvain Lachance; Nadine
Boudreau; Sofi Gagnon-Carignan; Ann Lévesque;
PharmaNet Canada, Québec, Canada
Deception in the Deuteriums: Errors Associated
with Deuterated Internal Standards in LC-MS/MS
Bioanalysis; Brian Rappold; Audrey Harvey; Matthew
Salske; Patrick Bell; Jennifer Andre; Michele Glinn;
Essential Testing, Collinsville, Il
Improved Assay Selectivity for the Determination of
Hydroxymidazolam in Capillary Microsampling Extracts
using LC-MS3 on a Hybrid Linear Ion Trap; Jeffry
Plomley; Mohamed Makhloufi; Alexandre Pimenov; Charles
River Laboratories, Senneville, Canada
Development and Validation of LC/MS/MS Method
with Extra Small Injection Volume for Quantitative
Determination of Alprazolam in Human Plasma; Zhaoqi
Zhan1; Jie Xing1; Gabriel Onn Kit Loh2; Kok Khiang Peh2;
1
Shimadzu (Asia Pacific) Pte Ltd, Singapore, Singapore;
2
School of Pharmaceutical Sciences, Universiti Sain,
Malaysia, Minden, Penang, Malaysia
Determination of Diuretics in urine Using Multi-Walled
Carbon Nanotubes Dispersive Solid Phase Extraction
Combined with Liquid Chromatography-Tandem Mass
Spectrometry; Tse-Tsung Ho; Chung-Yu Chen; Maw-Rong
Lee; National Chung-Hsing University, Taichung, TAIWAN
TurboIonSpray vs. APCI for the Determination of
Furosemide in Human Plasma by LCMSMS; Jason
Bilodeau; Marie-Claude Théberge; Nadine Boudreau; Ann
Lévesque; PharmaNet Canada, Quebec, Canada
Importance of Assessing Whole Blood Stability during
Validation of Serum and Plasma LCMSMS Methods;
Sylvain Lachance; Nadine Boudreau; Sofi Gagnon-Carignan;
Ann Lévesque; PharmaNet Canada, Quebec, Canada
Interferences from Borosilicate Laboratory Material:
Investigation and Application to LC-MS/MS Bioanalysis
of Valproic Acid; Pierre-Yves Caron; Nathalie Pelletier;
Nadine Boudreau; Ann Lévesque; PharmaNet Canada,
Quebec, Canada
Ultra Low Limit of Detection of Mometasone Furoate
in Human Plasma by UPLC-MS/MS; Pierre-Yves Caron;
Nicolas Jean; Marie-Claude Théberge; Nadine Boudreau;
Ann Lévesque; PharmaNet Canada, Quebec, Canada
Investigation of Long-Term Stability of Rabeprazole
Thioether Metabolite and Its Impact on Rabeprazole
Quantitation; Sébastien Gagné; François Viel; Nadine
Boudreau; Ann Lévesque; PharmaNet Canada, Quebec,
Canada
Hemolysis and Matrix Effect Issues during Method
Development of Promethazine in Human Plasma;
Eric Morin; Nathalie Pelletier; Sylvain Lachance; Nadine
Boudreau; Ann Lévesque; PharmaNet Canada, Quebec,
Canada
Comparison of LDTD-MSMS and LCMSMS for the
Determination of Testosterone in Human Serum; Sylvain
Lachance1; Nadine Boudreau1; Ann Lévesque1; Serge
Auger2; Pierre Picard2; 1PharmaNet Canada, Quebec,
Canada; 2Phytronix Technologies, Québec, Canada
Low Detection Limit and Stability Issues during Method
Development of Apomorphine in Human Plasma; Guy
Havard; Marie-Claude Théberge; Nadine Boudreau; Ann
Lévesque; PharmaNet Canada, Québec, Canada
Analysis of Ocular Tissues: Investigation of Potential
Matrix Effects; Vikki Tsefrikas; Dylan Bennett; Kyle
Goodsell; Allysen Meymaris; Agilux Laboratories,
Worcester, MA

PAGE 54					

MP 028

MP 029

MP 030

Effect of Special Population Matrices on Quantitation
of Drugs with Wide Range of Plasma Protein Binding
Levels Using LC-MS/MS Method; Dongmei Zhou; David
Wilson; Mai Nguyen; Erin Harmon; Kyle Nishikawa; Li-Tain
Yeh; Ardea Biosciences, San Diego, CA
Ion Suppression in Rat Brain Due to Phospholipids and
Its Impact on Sensitivity and Electrospray Response
Function for Small Molecules; Navjot Chahal; Luis Sojo;
Xenon Pharmaceuticals, Burnaby, Canada
Improving the Sensitivity, Precision and Accuracy of
PGIs Analysis by LC-MS; Peng Wang; Alwyn Forbes;
Naijun Wu; Celgene Corporation, Summit, NJ

Drug Metabolism: High Throughput Analysis, 031 - 040
MP 031

MP 032

MP 033

MP 034

MP 035

MP 036

MP 037

MP 038

MP 039

MP 040

Computer Assisted Metabolite Identification,
Application in Cytochrome Reaction Phenotyping;
Esra Nurten Cece1; Kristen Eickhoff2; Andreas Brink2;
Ismael Zamora3; Axel Paehler2; 1Pompeu Fabra University,
Barcelona, Spain; 2F. Hoffmann-La Roche Ltd, Basel,
Switzerland; 3Molecular Discovery, London, UK
Combining in vitro Intrinsic Clearance and Metabolic
Soft Spot Identification in Early Drug Discovery; Marina
Slavsky1; Keeley Murphy2; Ismael Zamora3; Thomas
O’Shea1; Maria Fitzgerald1; 1DMPK, Sanofi, Waltham, MA;
2
Thermo Fisher Scientific, San Jose, CA; 3Lead Molecular
Design, Barcelona, Spain
Integrating Qualitative and Quantitative Measures
across HRMS and Qtrap MS Platforms in Early Stage
Metabolic Stability Screening in Drug Discovery;
Jianhua Liu1; Veronica A. Zelesky1; Anthony J. Romanelli2;
Loren Y. Olson2; John S. Janiszewski1; 1Pfizer, Inc, Groton,
CT; 2AB Sciex, Framingham, MA
Differential Mobility Spectrometry as a Measure
of Physicochemical Properties Related to in vitro
Absorption (Permeability, Solubility and Lipophilicity);
John Janiszewski 1; Yves LeBlanc2; Bradley Schneider2;
Tom Covey2; George Chang1; Charles Rotter1; Manthena
Varma1; Troutman Matthew1; 1Pfizer Inc., Groton, CT; 2AB
Sciex, Concord, Ontario, Canada
Microsampling Method Using 1 µL of Human Blood to
Determine Pharmacokinetic Parameters of Dextrorphan
Using LDTD-MS/MS; Jean Lacoursiere; Annick Dion;
Serge Auger; Pierre Picard; Phytronix Technologies,
Quebec City, Canada
A High-Throughput, Accurate-Mass Approach for
Plasma Protein Binding Analysis Using SPE/TOF-MS;
Kari Schlicht; Vaughn Miller; William LaMarr; Can Ozbal;
Agilent Technologies, Wakefield, MA
Determination of a DGAT1 Inhibitor in Human Plasma
Using microLC-MS/MS: Comparison of microLC vs.
Conventional LC Methods for Bioanalysis; Tapan
Majumdar; Shari Wu; Adam Bentley; Jimmy Flarakos;
Novartis Pharmaceuticals Corporation, East Hanover, NJ
Reducing Gradient Cycle Time for Increased
Throughput Using Dual-Stream LC/MS/MS Bioanalysis;
Mary Piotrowski1; Carrie Funk1; John Janiszewski1; Hui
Zhang1; Brendon Kapinos1; Anthony Romanelli2; 1Pfizer,
Groton, CT; 2AB Sciex, Framingham, MA
Optimizing High-Throughput LC/MS/MS “trap-andelute” Bioanalysis in Drug Discovery; Brendon Kapinos1;
John Janiszewski1; Mary Piotrowski1; Hui Zhang1; Carrie
Funk1; Wayne Lootsma2; Will Schramm2; 1Pfizer, Groton,
CT; 2Sound Analytics, Niantic, CT
Development of High Speed CYP Cocktail Inhibition
Assay Using UHPLC-MS/MS; Ichiro Hirano; Miho
Kawashima; Natsuyo Asano; Kiyomi Arakawa; Yoshihiro
Hayakawa; Shimadzu Corporation, Kyoto, Japan

61ST ASMS CONFERENCE ON MASS SPECTROMETRY

MONDAY POSTERS

Metabolomics: Identification of Unknown Metabolites, 041-059
MP 041

MP 042

MP 043

MP 044

MP 045

MP 046

MP 047

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Improved Unknown Metabolite Identification by
Combining Smart Isotope Tags and Ratio Analysis MS
and NMR Heterospectroscopy; G. A. Nagana Gowda1;
Haiwei Gu1; Fariba Tayyari2; Daniel Raftery1, 3; 1University
of Washington, Seattle, WA; 2Purdue University, West
Lafayette, IN; 3Fred Hutchinson Cancer Research Center,
Seattle, WA
Metab-ID: An Automated Tool for Metabolite
Identification from MS1 Data; T. Mamie Lih1; Ke-Shiuan
Lynn1; Hui-Yin Chang1; Mei-Ling Cheng2; Ming-Shi Shiao2;
Wen-Harn Pan3, 4; Ting-Yi Sung1; Wen-Lian Hsu1; 1Institute
of Information Science, Academia Sinica, Taipei, Taiwan;
2
Chang Gung University, Taoyuan, Taiwan; 3National Health
Research Institutes, Mialoli, Taiwan; 4Institute of Biomedical
Sciences, Academia Sinica, Taipei, Taiwan
Annotation and Identification of Fragmentation of
Known Metabolites and Elucidation of Possible Known
Unknowns with Fragmentation Analysis; Hongping Dai;
Annie Evans; Corey DeHaven; Metabolon, Durham, NC
Automated Compound Identification Using Product
Ion Scanning with Accurate Mass Measurement and
Compound Database Searching for Non-Targeted
Metabolomics; Tairo Ogura 1, 2; Faith Hays3; Takeshi
Bamba1; Eiichiro Fukusaki1; 1Graduate School of
Engineering, Osaka University, Osaka, Japan; 2Shimadzu
corporation, Kyoto, Japan; 3Shimadzu Scientific
Instruments, Columbia, MD
A Platform to Identify Endogenous Metabolites Using
a Novel High Performance Orbitrap and the m/zCloud
Library; Junhua Wang 1; David Peake1; Robert Mistrik2;
Yingying Huang1; 1Thermo Fisher Scientific Inc, San Jose,
CA; 2HighChem, Ltd., Bratislava, Slovakia
Utilization of Metabolic Network Information for
Improved Metabolite Identification by LC-MS; Bin Zhou;
Habtom Ressom; Georgetown University, Washington, DC
Testing the Limits of a New, Extremely Accurate
HPLC Retention Prediction Methodology (www.
retentionprediction.org); Allison Haaning; Jonathan
Schellenberg; Paul Boswell; University of Minnesota, Saint
Paul, MN
The Ideal Stationary Phase for an HPLC Retention
Database; Joseph Manulik; Paul Boswell; University of
Minnesota, St. Paul, MN
An Inter-Laboratory Study on a New, Extremely
Accurate Retention Prediction Methodology for GC-MS
(www.retentionprediction.org); Brian Barnes1; Michael
Wilson1; Panhia Yang1; Mark Vitha2; Amanda Tawfall6; Lloyd
Sumner6; Adam Heuberger3; Corey Broeckling3; Jessica
Prenni3; Henry Corcoran4; Gregory Janis4; Shilpi Chopra5;
Nicholas Snow5; Paul Boswell1; 1University of Minnesota,
St. Paul, MN; 2Drake University, Des Moines, IA; 3Colorado
State University, Fort Collins, CO; 4Medtox Scientific, Inc.,
St. Paul, MN; 5Seton Hall University, South Orange, NJ;
6
Samuel Roberts Noble Foundation, Ardmore, OK
‘Sequencing’ the First Plant Metabolome, and the
Systematic Annotation of the Metabolic Composition of
the Model Legume Medicago truncatula; Lloyd Sumner1;
Zhentian Lei1; Dennis Fine1; Daniel Wherritt1; David
Huhman1; Kota Kera2; Hidezuki Suzuki2; Kazuki Saito3; 1The
Samuel Roberts Noble Foundation, Ardmore, OK; 2Kazusa
DNA Research Institute, Chiba, Japan; 3RIKEN Plant
Science Center, Yokohama, Japan
FT-ICR Based “Ultrafast Statistical Profiling”:
Myxobacterial Secondary Metabolite Profiling
for Quickly Pinpointing and Identifying Marker
Compounds; Aiko Barsch1; Matthias Witt 1; Christopher

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Thompson2; Daniel Krug3; Thomas Hoffmann3; Rolf
Mueller3; 1Bruker Daltonik GmbH, Bremen, Germany;
2
Bruker Daltonic Inc., Billerica, MA; 3Helmholtz Institute for
Pharmaceutical Research, Saarbruecken, Germany
Defensive Chemistry: MS-based Characterization of
Sesquiterpene Lactone - and Hydroxybenzeneacetic
Acid- Derived Defensive Metabolites of Taraxacum
officinale Root Latex; Sven Heiling1; Meret Huber1; Andrea
Kiehne2; Christian Paetz1; Michael Reichelt1; Sandy Yates3;
Aiko Barsch2; Matthias Erb1; Jonathan Gershenzon1; Ian T.
Baldwin1; 1Max Planck Institute for Chemical Ecology, Jena,
Germany; 2Bruker Daltonik GmbH, Bremen, Germany;
3
Bruker Daltonics, Fremont, CA
LC-MS/MS-based Structural Analysis of Novel Enniatins
Produced by Canadian Strains of Fusarium avenaceum
in Liquid Culture; Azeret Zuniga 1, 2; Whynn Bosnich1;
Kanak Bala1; Linda Harris1; Steve Gleddie1; Zoltan Mester2;
1
Agriculture and Agri-Food Canada, Ottawa, Canada;
2
National Research Council, Ottawa, Canada
Online Study on Metabolites Profiles of Sixteen
Clausenamide Enantiomers in vitro by Liquid
Chromatography/Quadrupole Ion Trap/Time-of-Flight
Mass Spectrometry; Ma Chao1, 2; Feng Ru1; Wang Yan1;
Qiu xiongxiong2; 1Chinese Academy of Medical Sciences,
Beijing, China; 2Shimadzu Global COE, Shimadzu (China)
Co., Ltd., Beijing, China
Profiling Biosynthetic Intermediates from Camptotheca
acuminata Using Liquid Chromatography, Multiplexed
Collision-Induced-Dissociation and Time-of-Flight Mass
Spectrometry; Sujana Pradhan; A. Daniel Jones; Michigan
State University, East Lansing, MI
Evidence for Glucuronide and Glutathione
Conjugation of Glyceollins in Rats by On-Line Liquid
Chromatography-Electrospray Ionization Tandem Mass
Spectrometry; Syeda S. Quadri1; Robert E. Stratford2;
Richard B. Cole1, 3; 1Dept. of Chemistry, Univ. Of New
Orleans, New Orleans, LA; 2College of Pharmacy, Xavier
Univ., New Orleans, LA; 3Univ. P. et M. Curie (Paris 6), Paris
Cedex 05, France
The in vitro Study of the Metabolism of 3,
4-Methylenedioxymethamphetamine (MDMA) in Human
Hepatocytes; Chengan Du; Hampton University, Hampton,
VA
Metabolomics Approach to Determine A. flavus Cluster
27 Polyketide Synthase Metabolites: Evaluation of
UHPLC–Orbitrap MS and micro- LC–tripleTOF; José
Diana Di Mavungu1; Svetlana V. Malysheva1; Natalia AroyoManzanares2; Jeffrey W. Cary3; Kenneth C. Ehrlich3; Julie
Vanden Bussche1; Lynn Vanhaecke1; Deepak Bhatnagar3;
Sarah De Saeger1; 1Ghent University, Ghent, Belgium;
2
University of Granada, Granada, Spain; 3U.S. Department
of Agriculture, New Orleans, LA
NanoLC-MS/MS Metabolomics of Urinary Biomolecules
Following Intake of Grape Seed Extract in a Rodent
Model of Menopause; John Cutts; Landon Wilson;
Scott Sweeney; D. Ray Moore; Jeevan Prasain; Stephen
Barnes; Helen Kim; University of Alabama at Birmingham,
Birmingham, AL
Metabolomics: Untargeted Metabolite
Profiling (Methods), 060-080

MP 060

Quality Control and Data Extraction Validation for
High-Resolution Metabolomics; Vilinh Tran1; Karan
Uppal1; Milam Brantley2; Arshed Quyyumi1; Greg Gibson3;
Dean Jones1; 1Emory University, Atlanta, GA; 2Vanderbilt
University, Nashville, TN; 3Georgia Institute of Technology,
Atlanta, GA

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MP 064

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MP 067

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Global Characterization of SRM 1950 (Metabolites in
Human Plasma) Using Liquid Chromatography-Mass
Spectrometry; Kelly H. Telu; William E. Wallace III; Stephen
E. Stein; Yamil Simón-Manso; NIST, Gaithersburg, MD
Sheathless Capillary Electrophoresis Mass
Spectrometry: Investigation Using High Resolution
Accurate Mass MS for Metabolome Analysis; Junhua
Wang 1; John Hudson2; Maria Prieto Conaway1; David
Peake1; Yingying Huang1; Andreas Huhmer1; 1Thermo Fisher
Scientific Inc, San Jose, CA; 2Beckman Coulter, Inc., Brea, CA
Combination of Double Isotopic Labeling and High
Resolution Mass Spectrometry: A Novel Method for
Untargeted Fungal Metabolic Profiling; Patricia M.
Cano1, 2; Emilien L. Jamin1, 2; Souria Tadrist1, 2; Pascal
Bourdaudhui1, 2; Michel Péan3, 4; Laurent Debrauwer1, 2;
Isabelle P. Oswald1, 2; Marcel Delaforge5; Olivier Puel1,
2 1
; INRA, Toxalim, Research Center in Food Toxicology,
Toulouse, France; 2Université de Toulouse, INP, Toxalim,
Toulouse, France; 3CEA, DSV, IBEB & CNRS Bio. Vég.
et Microbio. Envir, Saint-Paul-les-Durance, France; 4AixMarseille Université, Saint-Paul-les-Durance, France; 5CEA
Saclay, iBiTec-S, SB2SM and URA CNRS 8221, Gif sur
Yvette, France
Evaluation of Different Dansylation Reaction Conditions
for Isotope Labeling of Metabolites in Metabolome
Profiling of Biological Samples; Jared Curle; Liang Li;
University of Alberta - Department of Chemistry, Edmonton,
Canada
Variety and Specificity of Granules in a Cell, Detected
by Live Single-Cell Mass Spectrometry; Yuki Yamamoto2;
Tsuyoshi Esaki1; Hajime Mizuno1; Sachiko Date1; Naohiro
Tsuyama2; Tsutomu Masujima1; 1Quantitative Biology
Center (QBiC), Riken, Suita, Japan; 2Hiroshima University,
Hiroshima, Japan
Isotope Labeling Liquid Chromatography-Mass
Spectrometry in Metabolite Biomarker Discovery for
Mild Cognitive Impairment Disease; Tran Tran; Roger A.
Dixon; Liang Li; University of Alberta, Edmonton, Canada
xMSanalyzer: Automated Pipeline for Improved Feature
Detection and Downstream Analysis of Large-Scale,
Non-Targeted Metabolomics Data; Karan Uppal1, 2; Dean
Jones1; 1Emory University, Atlanta, GA; 2Georgia Institute of
Technology, Atlanta, GA
An Improved Isotopic Labeling Protocol for LC-MS
Metabolomic Profiling of Carboxylic Acids in Biofluids
and Cell Extracts; Jun Peng; Liang Li; University of
Alberta, Edmonton, Canada
Understanding the Biology of Higher Organisms
through GoogleMAPS-type Visualization of Specialized
Metabolites Found to be Associated with Microbial
Communities; Pieter Dorrestein; Christopher Rath;
Vanessa Phelan; Guo Yurong; Jeramie Watrous; Mingxun
Wang; Robbie Quinn; Yan Wei Lim; Kathleen Dorrestein;
Nuno Bandeira; Theodore Alexandrov; University of
California, San Diego, Skaggs school, La Jolla, CA
Novel Software Solutions for Liquid ChromatographyHigh Resolution MS (LC-HRMS) Metabolite Profiling
of Legumes under Drought and Fungal Infection
Conditions; Michael Dickinson1; Martin Wells2; Mark
Harrison1; Rosario Romero1; Adrian Charlton1; Jackson
Pope2; 1The Food and Environment Research Agency, York,
UK; 2Nonlinear Dynamics, Newcastle upon Tyne, UK
Unexpected Complexity of In-Source Fragmentation:
The Utility of Spectral Searching for Compound
Annotation in Non-Targeted Metabolite Profiling
Studies; Corey Broeckling; Jessica Prenni; Colorado State
University, Fort Collins, CO

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MP 074

MP 075

MP 076

MP 077

MP 078

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MP 080

Metabolite Profiling and Metabolic Fingerprinting of
Arabidopsis Mutants Using Atmospheric Pressure GCMSE Approach and Multivariate Statistical Analysis;
Carolina Salazar; Nobuhiro Suzuki; Ron Mittler; Vladimir
Shulaev; University of North Texas, Denton, TX
Improved Methodology for Metabolomics Data
Acquisition Workflow: Utilization of Electron Impact
and Chemical Ionization High Resolution Time-Of-Flight
Mass Spectrometry; David Alonso; Joe Binkley; John
Heim; Leco Corporation, St. Joseph, MI
Rapid Clinical Biofluid Profiling with Rapid Evaporative
Ionisation Mass Spectrometry; Kate Leary; Sabine
Guenther; Zoltán Takáts; Imperial College London, London, UK
Comprehensive Liquid Chromatography Coupled to
High Resolution Mass Spectrometry Methods for the
Global Metabolic Profiling of Human Serum; Samia
Boudah1, 2; Sandrine Aros-Calt1, 3; Marie-Françoise Olivier1;
François Fenaille1; Christophe Junot1; 1LEMM-CEA-Saclay,
Gif-Sur-Yvette, France; 2GlaxoSmithKline - Centre de
recherche F.Hyafil, Villebon-sur-Yvette, France; 3bioMérieux
S.A, Chemin de l’Orme, Marcy l’Etoile, France
An Efficient Automated Dual pH Dual Polarity HILIC
Based LC-MS Approach to the Analysis of the
Metabolome; James Cox; University of Utah, Salt Lake
City, UT
LC-HRMS Based Stable Isotopic Labeling-Assisted
Metabolomics: Using MetExtract Software for the
Global Characterization of the Plant Pathogenic
Fungus Fusarium graminearum; Christoph Büschl;
Bernhard Kluger; Gerlinde Wiesenberger; Stefan Bödi;
Romana Stückler; Joseph Strauss; Gerhard Adam; Rainer
Schuhmacher; University of Natural Resources and Life
Sciences, Tulln, Austria
Utilization of GC-TOFMS for Metabolomics Using
a Standardized Global Approach from Sample
Preparation to Data Interpretation; John R. Heim; Joe
Binkley; David Alonso; LECO Corporation, St. Joseph, MI
Isotopic Ratio Outlier Analysis (IROA) of Genetically
Engineered Myxococcus xanthus Strains Using Ultra
High Resolution Mass Spectrometry; Daniel Krug1;
Aiko Barsch2; Rolf Müller1; Chris Beecher3; Felice de
Jong3; 1Helmholtz-Institute for Pharmaceutical Research,
Saarbrücken, Germany; 2Bruker Daltonik GmbH, Bremen,
Germany; 3NextGen Metabolomics Inc, Ann Arbor, Michigan
MsCompare: An Untargeted GC/MS Metabolomics
Platform for Quality Control and Accurate
Deconvolution; Claartje Van Der Kroft; MsMetrix,
Maarssen, Netherlands
Metabolomics: Sample Preparation, 081-084

MP 081

MP 082

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MP 084

Development of Isotope Labeling LC-MS for Metabolic
Profiling of Bacterial Cells and Its Application for
Bacterial Differentiation; Yiman Wu; Liang Li; University of
Alberta, Edmonton, Canada
Effective Extraction Method and Stable-Isotope
Dansylation Labeling Combined with RPLC-FTMS for
the Analysis of Arabidopsis Thaliana Metabolome;
Chiao-Li Tseng; Michael Deyholos; Liang Li; University of
Alberta, Edmonton, Canada
Development of a Dilute-and-Shoot LC/MS/MS Method
with 21 Opiates in Urine; Simon Sheng; Kate Evans;
Francois Espourteille; Thermo, San Jose, CA
Metabolomics of Elaeis guineensis Leaves: From
Optimization of the Sample Preparation Steps to
Untargeted Metabolite Profiling Analysis; Luiz Henrique
Vargas2; José Antônio Ribeiro1; Daniel Sifuentes1;

61ST ASMS CONFERENCE ON MASS SPECTROMETRY

MONDAY POSTERS

Anselmo E. de Oliveira3; Manoel T. Souza Júnior1;
Clenilson Rodrigues1; Patrícia Verardi Abdelnur1; 1Embrapa
Agroenergy, Brasilia, Brazil; 2Federal University of Lavras,
Lavras, Brazil; 3Federal University of Goiás, Goiânia, Brazil
LC-MS: Chromatography, 085-130
MP 085

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MP 087

MP 088

MP 089

MP 090

MP 091

MP 092

MP 093

MP 094

MP 095

MP 096

Development of a HILIC-MS/MS Method for
Quantification of Decitabine in Human Plasma by Using
Lithium Adducts; Wenyi Hua; Michael Lesslie; Brian T.
Hoffman; Daniel Mulvana; Advion Bioanalytical Labs, a
Quintiles Company, Ithaca, NY
LC-MS Separation Tuning for Polar Hydrophilic
Metabolites on Complementary Zwitterionic HILIC
Columns; Tobias Jonsson1; Wen Jiang1; Anders Nordstrom2;
Petrus Hemstrom1; Patrik Appelblad1; 1Merck SeQuant AB,
Umeå, Sweden; 2Umea University, Umea, Sweden
Separation Efficiency and Selectivity of Ultra
Performance Columns for Hydrophilic Interaction
Liquid Chromatography (HILIC); Wen Jiang; Lena Westin;
Tobias Jonsson; Merck SeQuant AB, Umeå, Sweden
Ibuprofen Chiral Resolution Improvement by Water/
Acetonitrile Endotherm from LC-Pump Mixer; PierreYves Caron; Guy Havard; Nathalie Pelletier; Nadine
Boudreau; Ann Lévesque; PnarmaNet Canada, Québec,
Canada
Evaluation of Polar-Embedded ODS Column in
Supercritical Fluid Chromatography; Chiaki Aoyama1;
Takayuki Yamada2; Megumi Ishibashi2; Kensuke Okusa1;
Masakazu Takahashi1; Masayoshi Ohira1; Eiichiro
Fukusaki2; Takeshi Bamba2; 1GL Sciences Inc., Iruma,
Japan; 2Graduate School of Engineering, Osaka University,
Suita, Japan
Mass-Directed Chiral SFC Separations Versus
Asymmetric Synthesis in Drug Discovery; Kanaka
Hettiarachchi; Theravance, South San Francisco, CA
A Multidimensional System for Phosphopeptide
Analysis using TiO2 Enrichment and Ion-Exchange
Chromatography with Mass Spectrometry; Kun Cho;
Jisun Yoo; Eunmin Kim; Jong Shin Yoo; KBSI, Ochang,
South Korea
Quantitation of Adsorbed Plasma Proteins on Coated
and Non-Coated PLGA (poly(lactic-co-glycolic acid))
Nanoparticles by LC-MALDI; Tobias Schorge; Karim
Sempf; Michael Karas; Jörg Kreuter; Goethe-University
Frankfurt, Frankfurt, Germany
Increasing Peak Capacities for Peptide Separations
Using Long Microcapillary Columns and Sub 2 μm
Particles at 30,000+ psi; Kaitlin Fague; Justin Godinho;
Edward Franklin; Jordan Stobaugh; James Jorgenson;
University of North Carolina, Chapel Hill, NC
High pH Reversed Phase and Isoelectric Focusing
as Pre-fractionation Approaches for Complex
Proteome Analysis; Derek R Stein1; Xiaojie Hu2; Stuart J
McCorrister2; Garrett R Westmacott2; Francis A Plummer1,
2
; T Blake Ball1, 2; Michael S Carpenter1, 2; 1University of
Manitoba, Winnipeg, Canada; 2Public Health Agency of
Canada, Winnipeg, CA
Understanding Separation Parameters For Intact
Protein LC/MS Analysis Using Wide-Pore Core-Shell
Media; Michael Mcginley; Jeff Layne; Jason Anspach;
Phenomenex, Torrance, CA
High Resolution LC-MS Peptide Separations with
Formic Acid Mobile Phases Using Charge Surface
Modified C18 Columns; Matthew Lauber; Stephan Koza;
Kenneth Fountain; Waters Corporation, Milford, MA

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MP 098

MP 099

MP 100

MP 101

MP 102

MP 103

MP 104

MP 105

MP 106

MP 107

MP 108

In Depth Characterization of C18 and C18-like Solid
Phase Extraction materials, Indented for SubMicrogram Applications in Proteomic Workflows; Lasse
Falkenby1; Lena Haubro2; Nicolai Bache2; Martin R Larsen1;
Jens S Andersen1; 1University of Southern Denmark,
Odense, Denmark; 2Thermo Scientific, Odense, Denmark
In-house Construction of a UHPLC System in
Combination with Ti4+-IMAC aLlows Comprehensive
(phospho)Proteomic Profiling; Alba Cristobal; Marco
L. Hennrich; Houjiang Zhou; Albert J.R. Heck; Shabaz
Mohammed; Biomolecular Mass Spectrometry and
Proteomics Grou, Utrecht, The Netherlands
Bio-Solid Phase Extraction and Information Dependent
Tandem Mass Spectrometry for Deconvolution of
Complex Mixtures; Erica Forsberg; John Brennan;
McMaster University, Hamilton, Canada
Quantitative Analysis of Cytoplasmic UDPPeptidoglycan Intermediates in S. aureus Using LC-ESIMS/MS; Sudheer Bobba; Harika Vemula; William Gutheil;
University of Missouri- Kansas City, Kansas City, MO
Important Method Development Aspects of Restricted
Access Media-Based Trap-and-Elute Liquid
Chromatography-Mass Spectrometry Method for
Determination of Estrogens in Biological Samples;
Barbora Papoušková1; Hui Fan2; Karel Lemr1; Kevin
Schug2; 1RCPTM - Palacký University, Olomouc, Czech
Republic; 2University of Texas Arlington, Arlington, TX
Multisteroid Quantification in Bovine Plasma of Dairy
Cows by Isotopic Dilution Liquid Chromatography
Mass Spectrometry; Rosineide Costa Simas1, 2; Mirela
B Coelho2; Milton Maturana Filho3; Christina R. Ferreira3;
Marcos N Eberlin2; Guilherme P Nogueira1; Ed Hoffman
Madureira3; 1Laboratory of Animal Endocrinology, DAPSA
-UNESP-, Araçatuba, Brazil; 2ThoMSon Mass Spectrometry
Laboratory - UNICAMP, Campinas, Brazil; 3FZEA-USP,
Pirassununga, Brazil
Quantitation of Capecitabine, 5-Fluorouracil, 5-DFCR,
5-DFCR, Gemcitabine, dFdU Using LC-MS/MS with
Mixed Polarity Ion Mode Analysis; Sarah A. Burns;
Patricia Zagst; Wen Wee Ma; Gerald J. Fetterly; Roswell
Park Cancer Institute, Buffalo, NY
Mass Spectral Analysis of Bioactive Protein BowmanBirk Inhibitor (BBI) from Soybean; Parthasarathi Ghosh;
Daniel Staerk; Jennifer Wu; Charles Schasteen; DuPont
Protein Solutions, Solae, St. Louis, MO
Exploring Eluent pH for LC-MS Analysis Using
a New Extended pH Range Stable C18 Phase:
Opiate, Amphetamine and Antibiotic Mixtures; Alan
Mckeown1; Carl Zimmerman2; 1Advanced Chromatography
Technologies Ltd, Aberdeen, UK; 2MACMOD Analytical Inc.,
Chadds Ford, PA
High Throughput UHPLC-MS Peptide Mapping Method
for Characterization of Low Abundant Monoclonal
Antibody (MAb) Variants; Lisa Vampola; Melissa Alvarez;
Amy Hilderbrand; Marian Eng; Koman Joe; Victor Ling;
Genentech Inc, South San Francisco, CA
Efficient Column Cleaning for Poor Chromatography
Issue during Pyridoxal-5-Phosphate Bioanalysis by
LCMSMS; Marc Fournier; Marie-Josée Marcoux; Nadine
Boudreau; PharmaNet Canada, Quebec, Canada
A Novel Microflow-UHPLC MS/MS to Improve Sensitivity
and Throughput for Identification of 1α,25(OH)2-Vitamin
D2 and D3 in Human Serum; Khaled Mriziq1; Remco Van
Soest1; Tina Settineri1; Babu Purkayastha2; Subhakar Dey2;
1
Eksigent, Division of AB SCIEX, Dublin, CA; 2AB SCIEX,
Framingham, MA

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MP 111

MP 112

MP 113

MP 114

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MP 116

MP 117

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MP 121

Ultra High Throughput Analysis of
Immunosuppressants in Whole Blood by Microflow
LC-MS/MS; Daniel Blake; Daniel Leigh; Jason Causon; AB
SCIEX, Warrington, UK
Examination of the Sugar Analysis Using HPLC Method
Scouting System Coupled to Single Quadrupole Mass
Spectrometer; Steve Wishnies1; Miho Kawashima2;
Tadahiro Takahashi3; Hidetoshi Terada2; Yusuke Inohana2;
Kiyomi Arakawa2; Yoshihiro Hayakawa2; 1Shimadzu
Scientific Instruments, Inc., Columbia, MD; 2Shimadzu
Corporation, Kyoto, Japan; 3Shimadzu Analytical and
Mesureing Center, Inc., Kyoto, Japan
Maximizing Efficiency for UHPLC-LCMSMS Method
Development in Clinical Drug Monitoring; Sven Vedder1;
Anja Grüning1; Klaus Bollig2; Brigitte Richrath2; Robert
Ludwig1; 1Shimadzu Europe GmbH, Duisburg, Germany;
2
Shimadzu Germany GmbH, Duisburg, Germany
Characterization of Products Formed by Forced
Degradation of Amlodipine Besylate Using LC/MS/MS;
Shailesh Damale1; Shruti Raju1; Deepti Bhandarkar1; Rashi
Kochhar1; Shailendra Rane1; Ajit Datar1; Pratap Rasam1;
Jitendra Kelkar1; Divya Saxena2; 1Shimadzu Analytical
(India) Pvt. Ltd., Andheri (E), Mumbai, Maharashtra, India;
2
G.N.I.R.D., G.N. Khalsa College, Matunga, Mumbai,
Maharashtra, India
Validation of the Simultaneous Analysis of Heroin
Addiction Treatment Compounds Using LC/MS/MS with
a New Prelude SPLCTM System; Joseph Herman; Sarah
Fair; Dayana Argoti; Kerry Hassell; Thermofisher Scientific,
Franklin, MA
Determination of highly Polar, Active Nucleoside
Triphosphate (INX-09114) in Biological Matrices
Using a Multi-Mode HPLC Approach Coupled with
Mass Spectrometry; Ang Liu; Nga Kit Eliza Fung; AnneFrancoise Aubry; Jian Wang; Bristol-Myers Squibb,
Princeton, NJ
ESI Behaviour of Chloramphenicol, Thiamphenicol
and Florfenicol in Methanol Solution for LC-MS
and Implications on Their Detectability in Complex
Matrices; Prince Kolanyane; Ishmael Masesane; Kwenga
Sichilongo; University of Botswana, Gaborone, Botswana
Considerations in Combining Mass Spectral Data with
Orthogonal Detector Information in LC/MS; Thomas
E. Wheat; Aparna Chavali; Patricia McConville; Waters,
Milford, MA
Capabilities and limitatIons of Fast Online
Comprehensive Two-Dimensional Liquid
Chromatography; Imad Haidar Ahmad; Brian Barnes;
Robert Allen; Marcelo Filgueira; Peter Carr; University of
Minnesota, Minneapolis, MN
How to Accurately Measure Your HPLC Gradient with a
Mass Spectrometer (www.measureyourgradient.org);
Megan H. Magee; Brian B. Barnes; Joseph Manulik; Paul
G. Boswell; University of Minnesota, St. Paul, MN
Automated 2D UHPLC/MS Workflow on an EASY-nLC
1000; Fabio Marino1; Alba Cristobal1; Peter A. Nielsen2;
Nicolai Bache2; Albert J.R. Heck1; Shabaz Mohammed1;
1
Biomolecular Mass Spectrometry and Proteomics Grou,
Utrecht, The Netherlands; 2Thermo Fisher Scientific,
Odense, Denmark
Performance Evaluation of a Flexible, Easy-to-Use
Packed-Tip Column Device for Nanospray Enabled
LC-MS; Helena Svobodova; Amanda Berg; Ben Ngo; Gary
Valaskovic; New Objective, Inc., Woburn, MA
High Performance Liquid Chromatography – High
Performance Ion Mobility Spectrometry: An Ideal Tool
for 2D Separation of Isomers; Ching Wu; Anthony Midey;

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MP 130

Carol Moraff; Jianglin Wu; Robert Jackson; Excellims
Corporation, Acton, MA
Were you Fooled by Photodiode Array Detector? Suping
Zheng; PPD, Inc., Middleton, WI
Micro Flow Applications with Your Existing UHPLC
Hardware - A Practical Approach with Mass
Spectrometric Detection; Jinyuan Wang; Jonathan Beck;
Charles Yang; Guifeng Jiang; Thermo Fisher Scientific, San
Jose, CA
Considerations in Developing a Prototype Microfluidic
Trapping Column to Improve Mass and Volume
Capacity in an Integrated LC/MS System; Jay S.
Johnson; James Murphy; Angela Doneanu; Bob Jencks;
Robert Collamati; Waters Corporation, Milford, MA
On-line Chip-based Strategy for 2D Fractionation
– Comparing Peptides Found between 1D and 2D
Proteomic Analysis; Xiang Zhu1; Christie Hunter2; Jenny
Albanese2; Remco van Soest1; 1Eksigent, part of AB SCIEX,
Dublin, CA; 2AB SCIEX, Foster City, CA
Optimized Non-Linear Gradient Functions for Liquid
Chromatography in Shotgun Proteomics; Luminita
Moruz1; Peter Pichler2, 3; Karl Mechtler2, 4; Lukas Käll5;
1
Stockholm University, Stockholm, Sweden; 2Research
Institute of Molecular Pathology, Vienna, Austria; 3Christian
Doppler Laboratory for Proteome Analysis, Vienna, Austria;
4
Institute of Molecular Biotechnology, Vienna, Austria;
5
Royal Institute of Technology - KTH, Stockholm, Sweden
Separation of Proteins with Wide Variety of
Hydrophobicity Using a Reversed Phase 300Å Pore
Size Short Alkyl Chain Column; Justin Steve; Atis
Chakrabarti; Tosoh Bioscience LLC, King Of Prussia, PA
Intact Protein LC-MS, How to Overcome the
Challenges? Evert-Jan Sneekes1, 2, 3; Laurent Rieux1, 2,
3
; Mauro De Pra1, 2, 3; Christian Ravnsborg1, 2, 3; Dafydd
Milton1, 2, 3; Remco Swart1, 2, 3; 1Thermo Fisher Scientific,
Amsterdam, Netherlands; 2Thermo Fisher Scientific,
Odense, Denmark; 3Thermo Fisher Scientific, Runcorn, UK
2-Dimensional Separations: Which Dimension Plays
the Most Important Role in Protein Identification
Efficiency? Darryl Johnson1; Barry Boyes1, 2; Ron Orlando1;
1
Complex Carbohydrate Research Center, UGA, Athens,
GA; 2Advanced Materials Technology, Wilmington, DE
Development of Four Ultra-High Sensitivity LC-MS/MS
Methods for Determination of Four New Compounds
in Plasma in Support of Microdosing Studies; Yu-Luan
Chen1; Jingduan Chi2; Zong-Ping Zhang2; Estela Skende1;
Gary Maier1; 1Sunovion, Inc., Marlborough, MA; 2PPD,
Middleton, WI

LC-MS: Sample Preparation (Small Molecules), 131 - 150
MP 131

MP 132

MP 133

MP 134

Enhanced Resolution and Matrix Interference
Reduction for the Analysis of Vitamin D Metabolites;
Craig Aurand; Dave Bell; Hugh Cramer; Sigma Aldrich,
Bellefonte, PA
Optimized Automatic Sample Preparation of Biological
Fluids for Downstream LC-MS Analysis; Christine
Lehmann1; Robert Wohleb2; Roland Geyer2; Michal
Svoboda1; 1Application Specialist, Maennedorf, Switzerland;
2
Innovation Manager, Maennedorf, Switzerland
Determination of Sulfonamide Residues in Whole Milk
Using a Novel Lipid-Stripping Filtration Cartridge and
LC/MS/MS; Irina Dioumaeva; Agilent Technologies, Inc.,
Lake Forest, CA
An Evaluation of the Effectiveness of a Phospholipid
Removal Sorbent on LC/MS/MS Sensitivity, Method
Reproducibility, and LC Column Longevity; Jeff

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MP 136

MP 137

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Layne; Erica Pike; Stuart Kushon; Shahana Huq; Michael
McGinley; Phenomenex, Torrance, CA
Parallel Processing of Metabolites in Complex
Biological Fluids by Cation/Anion Exchange Solid
Phase Extraction on a Single 96 Well Plate; Frank Kero1;
Victor Vandell1; Elena Gairloch1; Lee Williams2; Adam
Senior2; Rhys Jones2; Helen Lodder2; Geoff Davies2; Alan
Eddington2; Claire Desbrow2; Gavin Jones2; Steve Jordan2;
1
Biotage, Charlotte, NC; 2Biotage GB, Cardiff, UK
Effective Strategies for Streamlining SPE Processing
Using Novel 96-well Plate Based Components Prior to
LC-MS/MS Analysis; Geoff Davies1; Lee Williams1; Adam
Senior1; Helen Lodder1; Kerry Stephens1; Rhys Jones1;
Steve Jordan1; Gavin Jones1; Claire Desbrow1; Victor
Vandell2; Frank Kero2; 1Biotage GB Limited, Cardiff, UK;
2
Biotage, Charlotte, NC
At-line Approach to Direct Solid Phase Extraction Mass Spectrometry; Esme Candish1; Emily F. Hilder1;
Robert A. Shellie1; Andrew Gooley2; Peter A. Dawes2; HansJürgen Wirth2; 1ACROSS,School of Chemistry, University
of Tasmania, Hobart, Australia; 2SGE Analytical Science,
Ringwood, Australia
Comparison of Protein Precipitation Techniques for
HPLC-MS/MS Assay of Vancomycin in Serum; Dodge
Baluya; Arnold Louie; George Drusano; Institute for
Therapeutic Innovation, UF, Orlando, FL
Determination of Underivatized Amino Acids in Certified
Yeast by microwave Vapor Acid Hydrolysis and UPLC
QTOF MS; Lilach Aviram; Margaret McCooeye; Zoltan
Mester; NRC, Ottawa, Canada
Optimisation, Refinement and Utility of Plasma MicroSampling Device for Use in Rodent Pharmacokinetic
and Toxicokinetic Studies; Philip Dennif1; Chester
Bowen2; Wesley Dopson1; Shazia Rehman1; Jim Kenney3;
Joe Siple3; 1GlaxoSmithKline R&D Ltd, Ware, UK;
2
GlaxoSmithKline R&D USA, Upper Merion, PA; 3Drummond
Scientific, Broomall, PA
Analysis of Phthalate Metabolites in Urine and
Serum Using Automated On Line Sample Preparation
Technique; Matthew Berube; Thermo Fisher Scientific,
Franklin, MA
Quantification of 2-Mercaptoethanol in Bulk Drug
Substance by LC-MS/MS; Yifan Shi1; Yinghe Li1; Meng
Fang1; William Wagner2; Aston Liu2; Sandro Nalli2; 1Alliance
Pharma, Malvern, PA; 2GlaxoSmithKline, King of Prussia,
PA
Fast and Highly Sensitive Determination of Oseltamivir
and Oseltamivir Carboxylate in Blood Samples by
UPLC-ESI-MS/MS; Lucie Loukotkova; Kellie Woodling;
Goncalo Gamboa da Costa; NCTR, US FDA, Jefferson, AR
Detection of Nerve Agents Treatment Drugs: Atropine,
Obidoxime, HI-6 and 2-PAM – Sensitive and Fast
Analytical Approach Using ESI-LC-MS/MS (MRM);
Thong Hiang Yeo; DSO National Laboratories, Singapore,
Singapore
Extraction of Drugs in Plasma by Automated LiquidLiquid Extraction for Downstream Analysis; Syed
Salman Lateef; Sundaram Palaniswamy; Suresh Babu CV;
Vinayak AK; Agilent Technologies, Bangalore, INDIA
LC-MS/MS Method Development for the Quantification
of Adenosine Levels as Biomarker of Inhibition of ENT1;
Andre Iffland; Abhishek R. Kulkarni; Vincenzo Pucci; Merck
INC., Boston, MA
Evaluation of Factors that Affect the Sensitivity
of Sulfonamides in Electrospray Ionization Mass
Spectroscopy; Kwenga Sichilongo; University of Botswana,
Gaborone, Botswana

MP 148

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MP 150

Determination of 11 Glucocorticoids in Cosmetic
Samples by An Automated SPE Workstation and HPLCESI-MS/MS; Jinran Zhang; Xudong Zhu; Guotao Lu; Jerry
Wang; Bonna-Agela Technologies, Tianjin, China
Screening of Seven Antibiotic Groups in Milk Samples
Using Automated On-line Sample Preparation in
Combination with UHPLC-High Resolution Time-ofFlight MS; Murat Celik1; Hasan Ozgen1; Jürgen Wendt2;
Wibke Peters2; Jutta Lintelmann3; 1ZIVAK Technologies,
Kocaeli, Turkey; 2LECO European LSCA Centre,
Moenchengladbach, Germany; 3Helmholtz Zentrum
München, Neuherberg, Germany
Automated Analysis of 25-hydroxyvitamin D2 and
D3 with APCI-LC-MS/MS Coupled with ZIVAK ONH
Automated Sample Preparation System; Murat Celik;
Hasan Ozgen; ZIVAK Technologies, Kocaeli, Turkey
MALDI Sample Preparation, 151 - 167

MP 151

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MP 154

MP 155

MP 156

MP 157

MP 158

MP 159

MP 160

Evaluation of Immuno-Enrichment for MALDI-TOF
MS Quantitative Analysis of Proteins in Biological
Specimens; Simona Colantonio1; Christopher A. Wolforth1;
Andrew G. Stephen1; Richard G. Saul1, 2; Gordon R.
Whiteley1; 1SAIC-Frederick Inc./FNL, Frederick, MD; 2Axo
Diagnostics, Gaithersburg, MD
Novel Method for Transcription Factor Identification:
Promoter-MALDI-MS/MS; Linda Nagore; YanWen Zhou;
Harry Jarrett; UT San Antonio, San Antonio, TX
Investigation of Microwave-assisted Disulfide Bond
Reduction by MALDI-TOF MS; Hyunjung Seo1, 2; Bong Kyo
Seo1, 2; Yongha In1, 2; Kyu Hwan Park1, 2; Yangsun Kim1, 2;
1
Hudson Surface Technology, Fort Lee, NJ; 2Applied Surface
Technology, Suwon, Korea
Enhanced Reproducibility in the MALDI-TOF Mass
Spectrometry Analysis of Serum N-glycans; Youngha
In; Sun Young Ahn; Seonghee Song; Chang Won Park;
Yangsun Kim; HST, Fort Lee, NJ
Quantitative Analysis of Sialylated Glycans by MALDITOF MS Using Matrix micro-Spotted Plate; Yongha In1,
2
; Sun Young Ahn1, 2; Bong Kyo Seo1, 2; Kyu Hwan Park1, 2;
Yangsum Kim1, 2; 1Hudson Surface Technology, Fort Lee,
NJ; 2Applied Surface Technology, Suwon, Korea
Preparation and Application of Monolithic Columns with
Immobilized Antibodies for Affinity Chromatography
Coupled to MS Detection of Neuropeptides; Shan Jiang;
Zichuan Zhang; Lingjun Li; UW-Madison, Madison, WI
Effect of Sample Composition and Preparation Method
on the Initial Velocity of Ions in MALDI TOFMS using a
Gridless Instrument; Brian Malys; April Holcomb; Kevin
Owens; Drexel University, Philadelphia, PA
Investigation and Optimization of Oligonucleotide
Sample Preparation for MALDI-TOF Analysis Using
3-hydroxypicolinic Acid (3-HPA); Stephen J. Hattan;
Kenneth Parker; Marvin Vestal; SimulTof Systems, Sudbury,
MA
Comparing DDP (dried droplet preparation) and GSP
(graphite supported preparation) Using Complex
Peptide Mixture from Elastase Digests in MALDI-MS;
Jan Gorka; David Fabacher; Marion Rohmer; Michael
Karas; Goethe University, Frankfurt, Germany
Alkylated Trihydroxyacetophenone as a Novel MALDI
Matrix for Hydrophobic Peptides; Yuko Fukuyama1;
Chihiro Nakajima1; Keiko Furuichi2; Kenichi Taniguchi1;
Shin-ichirou Kawabata1; Shunsuke Izumi2; Koichi Tanaka1;
1
Shimadzu Corporation, Kyoto, Japan; 2Hiroshima
University, Higashi-Hiroshima, Japan

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Novel Effect of Fullerene as an Additive in IR-MALDI
MS; Sadanori Sekiya; Kei Kodera; Kaori Kinoshita;
Kosuke Hosoi; Shinichi Iwamoto; Koichi Tanaka; Shimadzu
Corporation, Kyoto, Japan
A Graphene Based Soft Material Platform for Facile
“One-Step” Glycan Enrichment and Derivatization for
MALDI-TOF-MS Analysis; Haihong Bai1; Wanjun Zhang2;
Weijie Qin2; Xiaohong Qian2; 1Beijing Institue of Technology,
Beijing, China; 2BPRC, Beijing, China
Polymer & Matrix Thermal Treatments Using
Microfabricated Calorimetry Devices for Control And
Monitoring of Crystallization and Morphology for
Polymer MALDI/MS; Curtis Mowry1; Amy Allen1; Matthew
Moorman1; Adam Pimentel2; Elizabeth Schares1; Brittany
Hanlon1; 1Sandia National Laboratories, Albuquerque, NM;
2
LMATA Government Services, Albuquerque, NM
Phenylenevinylene Derivatives as UV-MALDI Matrices;
Laura J. Castellanos-García1; Hernando Rosales1; Cesar
A. Sierra-Avila2; Cristian Blanco-Tirado1; Marianny Y.
Combariza1; 1Escuela de Química, Univ Industrial de
Santander, Bucaramanga, Colombia; 2Departamento de
Química, Univ Nacional de Colombia, Bogotá, Colombia
Quantitative Analysis of Microcystins by MALDI-TOFMS; Humberto Milagre; Beatriz Sandonato; UNESP, Rio
Claro, Brazil
Boron Released from Borosilicate Glass Forms
Unusual in situ Derivatives in MALDI-MS; Takashi
Nishikaze; Shin-ichirou Kawabata; Koichi Tanaka;
Shimadzu Corporation, Kyoto, Japan
Investigation of the Effect of Halide Salts on Analyte
Signal Intensity in the MALDI Experiment; April
Holcomb1; Jennifer Dally2; Jonathan Haulenbeek1;
Francisco Guevara1; Catherine Bentzley2; Kevin G. Owens1;
1
Drexel University, Philadelphia, PA; 2University of the
Sciences, Philadelphia, PA

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Diagnostic Clinical Chemistry: Peptides/Proteins, 168 - 182
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MP 169

The 2012-2013 ABRF Proteomics Research Group
Study: Assessing Longitudinal Variability in Routine
Peptide LC-MS/MS Analysis; Maureen Bunger1; Tracy
Andacht2; Keiryn Bennett3; Cory Bystrom4; Matthew
Chambers5; Larry Dangott6; Felix Elortza7; John Leszyk8;
Henrik Molina9; Robert Moritz10; Brett Phinney11; David
Tabb 5; J. Will Thompson12; Xia Wang13; Jason Williams14;
1
BRITE, North Carolina Central University, Durham, NC;
2
Centers for Disease Control and Prevention, Atlanta, GA;
3
CeMM Research Center for Molecular Medicine, Vienna,
Austria; 4Cleveland HeartLab, Inc., Akron, OH; 5Vanderbilt
University, Nashville, TN; 6Texas A&M University, College
Station, TX; 7Centro de Investigacion Cooperativa en
Biociencias, Bilbao, Spain; 8University of Massachusetts,
Shrewsbury, MA; 9The Rockefeller University, New York,
NY; 10Institute for Systems Biology, Seattle, WA; 11University
of California, Davis, CA; 12Duke University, Durham, NC;
13
University of Cincinnati, Cincinnati, OH; 14National Institute
of Environmental Health Science, Research Triangle Park,
NC
Development of a Clinical cMet SRM Assay and
Assessment of Assay Precision in Archival Formalin
Fixed Paraffin Embedded (FFPE) sections; Wei-Li Liao1;
Sheeno Thyparambil1; Kathleen Bengali1; Jamar Uzzell1;
Marlene Darfler1; David Krizman1; Daniel Catenacci2; Jon
Burrows1; Todd Hembrough1; 1OncoPlex Diagnostics,
Rockville, MD; 2Department of Medicine, University of
Chicago, Chicago, IL

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Development of a Mass Spectrometry Based Approach
for the Diagnosis of Hemoglobinopathies; James
Scrivens1; Krisztina Radi1; Baharak Vafadar-Isfahani1;
Julia Smith2; Jane Newbold3; Nicholas Jackson3; 1Univ
of Warwick, Coventry, UK; 2Bruker UK, Coventry, UK;
3
Coventry and Warwickshire Hospital, Coventry, UK
A novel Mass Spectrometry-Based Assay for the
Accurate Measurement of Thyroglobulin from Patient
Samples Containing Antithyroglobulin Autoantibodies;
Yanni Zhang; Nigel J. Clarke; Richard E. Reitz; Quest
Diagnostics, San Juan Capistrano, CA
Development of a Clinical Gastroesophageal
Carcinoma Multiplexed SRM Assay and Assessment
of Assay Performance in Patient Tissues; Sheeno
Thyparambil1; Wei-Li Liao1; Jamar Uzzell1; Kathleen
Bengali1; Marlene Darfler1; David Krizman1; Daniel
Catenacci2; Jon Burrows1; Todd Hembrough1; 1Oncoplex
Diagnostics, Rockville, Maryland; 2University of Chicago,
Chicago, Illinois
Quantitative Determination of Tamm-Horsfall
Glycoprotein (THP, Uromodulin) in Urine Samples
Using LC-MS/MS Analysis; Nick Voskoboev; Olga Bondar,
PhD; John Lieske, M.D; Mayo Clinic, Rochester, MN
A New Approach to Lipoprotein Fingerprinting Using
the Mass Spectrometry of Proteins Associated with
High Density Lipoprotein (HDL) Nanoparticles; Ronald
D. Macfarlane; Texas A & M University, College Station, TX
Diagnosing Monoclonal Gammopathies Using TopDown Analysis of Immunoglobulin Light Chains in
Serum and Urine by LC-ESI-QTOF Mass Spectrometry;
David Barnidge1; Chad Botz1; Surendra Dasari2; Melissa
Snyder1; Jerry Katzmann1; David Murray1; 1Mayo Clinic/
DLMP, Rochester, MN; 2Mayo Clinic/Health Sciences
Research, Rochester, MN
Analysis of Disease-Related Hemoglobin Modifications
by Top-Down Mass Spectrometry; Didia Coelho
Graça1; Adelina Acosta Martin1, 2; Lorella Clerici2; Yury O.
Tsybin3; Ralf Hartmer4; Markus Meyer4; Kaveh Samii2;
Denis Hochstrasser1, 2; Pierre Lescuyer1, 2; Alexander
Scherl1; 1University of Geneva, Geneva, Switzerland;
2
Geneva University Hospitals, Geneva, Switzerland;
3
Ecole Polytechnique Fédérale de Lausanne, Lausanne,
Switzerland; 4Bruker Daltonics, Bremen, Germany
Quantitation of Insulin Grow Factors, IGF1 and IGF2
in Human Serum Using UHPLC-TOF; Sharanya Reddy;
Andrew Tyler; George Perkins; PerkinElmer, Shelton, CT
Quantification of Serum C-peptide by Isotope-Dilution
Mass Spectrometry Using Immobilized Antibody and
N-terminal Modification by Isotope-Dilution Mass
Spectrometry; Tomoya Kinumi; Ryoko Mizuno; Akiko
Takatsu; Bio-Medical Std Section, NMIJ AIST, Tsukuba,
Ibaraki, Japan
Simultaneous Transferrin and Apolipoprotein CIII
Glycoforms Analysis by Online Immuno-Affinity
Chromatography Electrospray Ionization Mass
Spectrometry; Coleman Turgeon1; Francesco Porta2;
Mark Magera1; Kristen Liedtke1; Dimitar Gavrilov1; Devin
Oglesbee1; Silvia Tortorelli1; Piero Rinaldo1; Dietrich
Matern1; Kimiyo Raymond1; 1Mayo Clinic, Rochester, MN;
2
Department of Pediatrics, University of Torino, Torino, Italy
Developing an iMALDI MS Assay for the Clinical
Determination of Plasma Renin Activity; Alexander
Camenzind1; J Grace van der Gugten2; Daniel Holmes3;
Christoph Borchers1, 4; 1University of Victoria-Genome BC
Proteomics Centre, Victoria, Canada; 2St. Paul’s Hospital,
Vancouver, Canada; 3University of British Columbia, St
Paul’s Hospital, Vancouver, Canada; 4Dept of Biochemistry
and Microbiology, U Victoria, Victoria, Canada

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Extending the Information Content of the MALDI
Analysis of Biological Fluids (Deep MALDI); Mark W.
Duncan1, 2; Senait Asmellash2; Jenna Allen2; Maxim Tsypin2;
Joanna Roder2; Heinrich Roder2; 1Univ. Colorado, School of
Medicine, Aurora, CO; 2Biodesix Inc., Boulder, CO
Applications of Mass Tags for Diagnostic Microchips;
Martina Lorey1; Ville Jokinen2; Belinda Adler3; Hong Yan3;
Rabah Soliymani1; Simon Ekström3; Thomas Laurell3;
Marc Baumann1; 1University of Helsinki, Helsinki, Finland;
2
Aalto University, Espooo, Finland; 3Lund University, Lund,
Sweden

MP 191

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MP 193

Imaging MS: Disease Markers, 183 - 206
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MP 185

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MP 187

MP 188

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MP 190

Vitamin D Induced Regulation of Lipids in a Mouse
Model of Breast Cancer Using Imaging MS and Gene
Array Analysis; Ami Grunbaum1; Pierre Chaurand2;
Richard Kremer1; 1McGill University Health Centre,
Montreal, Canada; 2University of Montreal, Montreal,
Canada
Time-of-Flight Secondary Ion Mass Spectrometry
(TOF-SIMS) Imaging Reveals Cholesterol Overload in
the Cerebral Cortex of Alzheimer Disease Patients;
Alain Brunelle1; Adina N Lazar2, 3; Claudia Bich1; Maï
Panchal2, 3; Nicolas Desbenoit1; Vanessa W. Petit4; David
Touboul1; Catherine Marquer2, 3; Olivier Laprévote5; Charles
Duyckaerts2, 3; 1CNRS, Institut de Chimie des Substances
Naturelles, Gif-sur-Yvette, France; 2Hôpital de la Salpêtrière,
AP-HP, Paris, France; 3Centre de Recherche de l’ICM,
Paris, France; 4LRTS, IRCM, DSV, CEA, Fontenay-auxRoses, France; 5Université Paris-Descartes, Paris, France
Profiling and Imaging MS of the Post-Injection
b-Amyloid Mobility in Mouse Brain Tissues Sections;
Aurelien Thomas1; Nathan Heath Patterson1; Stéphane
Epelbaum2; Pascale Lacor3; Benoît Delatour2; Pierre
Chaurand1; 1University of Montreal, Montreal, Canada;
2
Inserm/CNRS/UPMC, Hôpital de la Pitié-Salpêtrière, Paris,
France; 3Cognitive Neurology and Alzheimer’s Disease
Center, Chicago, IL
Imaging Mass Spectrometry Helps Predict Healing
Course in Acute Wound Healing; Domenico Taverna1,
3
; Jeffrey M. Spraggins2, 3; Joshua J. Nicklay3; Lillian B.
Nanney4; Alonda C. Pollins4; Giovanni Sindona1; Richard M.
Caprioli2, 3; 1Universita’ della Calabria, Dept. of Chemistry,
Arcavacata Di Rende, CS, Italy; 2Vanderbilt University,
Dept. of Biochemistry, Nashville, TN; 3Vanderbilt University,
Mass Spec. Research Center, Nashville, TN; 4Vanderbilt
University, Dept. of Plastic Surgery, Nashville, TN
Imaging Mass Spectrometry of Normal and PKD Mouse
Kidney Tissues Using MALDI-MS; Rachel Marvin; Yang
Xu; Maki Takahashi; Leif Hanson; Surya Nauli; Dragan
Isailovic; University of Toledo, Toledo, Ohio
Matrix-assisted Laser Desorption Ionization Imaging
Mass Spectrometry (MALDI-IMS) of Aging in Rat
Skeletal Muscle; Laetitia Theron1; Daniel Bechet1; Didier
Viala1; Jeremy Pinguet2; Christophe Chambon1; 1INRA,
Theix, France; 2CHU, Clermont-Ferrand, France
Mass Spectrometric Imaging of Myelin Basic Protein
and Its Breakdown Products in Traumatic Brain Injury;
Manasi Mangaonkar; Kevin Wang; Richard Yost; David
Powell; University of Florida, Gainesville, FL
Multimodality Imaging Mass Spectrometry for Colocalization of Trace Metals and Proteins in Abscesses
in Murine Tissue from Staphylococcus aureus Infection;
Jessica L. Moore; Yaofang Zhang; Thomas E. Kehl-fie;
Joshua J. Nicklay; Eric P. Skaar; Richard M. Caprioli;
Vanderbilt University, Nashville, TN

MP 194

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MP 196

MP 197

MP 198

MP 199

MP 200

Analysis of Bacterial Biofilms Using MALDI Imaging
Mass Spectrometry: Protein Spatial Distribution within
Uropathogenic E. coli Biofilms; Kyle A. Floyd; Jessica L.
Moore; Carrie L. Shaffer; Maria Hadjifrangiskou; Richard M.
Caprioli; Vanderbilt University, Nashville, TN
Identifying Lipid, Glycan and Protein Correlates of
Vitamin D3 Supplemented Prostate Tissues Using
MALDI-MS Imaging; Sebastiano Gattoni-Celli; Ellen Jones;
Drew Schoenling; Stephen Savage; Richard Drake; Medical
University of South Carolina, Charleston, SC
Imaging Mass Spectrometry (IMS) Approach for
the Assessment of Meniscus Degeneration; Jörg
Kriegsmann1, 2; Rita Casadonte1; Friederike Zweynert2;
Vanessa Schommer2; Jenny Petzold3; Axel W. Baltzer3;
Markus Granrath3; Jens Fuchser4; Sören Deininger4; Mike
Otto1, 2; 1Proteopath GbR, Trier, Germany; 2Institute for
Molecular Pathology, Trier, Germany; 3Center for Molecular
Orthopedics, Düsseldorf, Germany; 4Bruker Daltonik GmbH,
Bremen, Germany
Typing of Renal Amyloidosis in Formalin-Fixed ParaffinEmbedded (FFPE) Biopsy Specimens by MALDI
Imaging Mass Spectrometry (IMS); Rita Casadonte1; Jens
Fuchser2; Sören Deininger2; Kerstin Amann3; Mike Otto1,4;
Jörg Kriegsmann1,4; 1Proteopath GbR, Trier, Germany;
2
Bruker Daltonik GmbH, Bremen, Germany; 3University
Erlangen-Nürnberg, Erlangen, Germany; 4Histology,
Cytology and Molecular Diagnostics, Trier, Germany
Discovery and Localization of Modified Lipids
in Kidneys of Diabetic Mouse Model using Mass
Difference Scanning and Imaging Mass Spectrometry;
Kerri Grove; Raf Van de Plas; Jeffery Spraggins; Paul
Voziyan; Raymond Harris; Billy Hudson; Richard Caprioli;
Vanderbilt University, Nashville, TN
Identification of Potential Biomarkers of Atherosclerotic
Plaque Vulnerability by Imaging Mass Spectrometry;
Patrícia Schneider Yogi1; Gabriela Venturini1; Karina Helena
Morais Cardozo2; Pamella Araújo Malagrino1; Valdemir
Melechco Carvalho2; Paulo Sampaio Gutierrez1; José
Eduardo Krieger1; Alexandre da Costa Pereira1; 1Heart
Institute (InCor) - Medical School, USP, Sao Paulo, Brazil;
2
Fleury Group, Sao Paulo, Brazil
Matrix Assisted Laser Desorption Ionization Imaging
Mass Spectrometry Reveals a Different Molecular
Composition in Human Healthy and Osteoarthritic
Synovial Membrane; Berta Cillero Pastor1; Gert B. Eijkel1;
Francisco J. Blanco2; Ron M.A. Heeren1; 1FOM Institute
AMOLF, Amsterdam, The Netherlands; 2INIBIC-CH
Universitario A Coruña, A Coruña, Spain
Towards Lipidomics of Low-Abundant Species for
Exploring Biological Relevance Guided by HighResolution Mass Spectrometry Imaging; Cimino
Jonathan1, 2; Calligaris David 2; Far Johann2; Debois
Delphine 2; Blacher Silvia 1; Sounni Nor Eddine 1; Noel
Agnès1; De Pauw Edwin 2; 1Laboratory of Tumor and
Development Biology, GIGA, Belgium, Liege; 2Mass
Spectrometry Laboratory, GIGA-R, Belgium, Liege
Integrating Multivariate Data Analysis and +/- Mode
MALDI Imaging MS for Interrogating Animal Models
of Myocardial Infarction; Robert Menger1; Andras Kiss2;
Raquel Hendershot1; Brad Wacker3; Gert Eijkel2; Ron
Heeren2; David Ford3; Richard Yost1; 1University of Florida,
Gainesville, FL; 2FOM Institute AMOLF, Amsterdam, The
Netherlands; 3Saint Louis University, St. Louis, MO
MALDI Imaging and FTICR MS Mapping of Lipids
Alterations in Spinal Cord Injury; Huiling Liu 1; Karin B.
Nilsson1, 2; Huan He3, 4; Alexander Shavkunov1; Young S.
Gwak2; Shayne N. Hassler2; Kathia M. Johnson2; Norelle

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C. Wildburger1; Nicolas L. Young3, 4; Alan G. Marshall3,
4
; Claire E. Hulsebosch2; Carol L. Nilsson1; 1Department
of Pharmcology & Toxicology, UTMB, Galveston, TX;
2
Neuroscience and Cell Biology, UTMB, Galveston, TX;
3
Ion Cyclotron Resonance Program, NHMFL, Tallahassee,
FL; 4Department of Chemistry and Biochemistry, FSU,
Tallahassee, FL
Imaging and Profiling of Lipids in Human Tumors;
Roberto Fernández1; Antonio Veloso1; Silvia Terés2; Monica
Higuera2; Daniel H Lopez2; Francisca Guardiola2; Xavier
Busquets2; Pablo V. Escribá2; Gwendolyn Barceló-Coblijn2;
Jose A. Fernández1; 1University of Basque Country (UPV/
EHU), Leioa, Spain; 2University of the Balearic Islands,
Palma, Spain
Identification Of Cancer Markers by Mass Spectrometry
Imaging of Tissue Micro Arrays; Marcus Wurlitzer1;
Carina Borkowski2; Sinje Odinga Odinga2; Malte Buchholz
Buchholz2; Christina Koop2; Maryam Omidi1; Olga Kraus1;
Michael Becker5; Matthias Witt5; Dennis Trede4; Maria
Trusch6; Sarah Minner Minner2; Thorsten Schlomm3; Ronald
Simon2; Guido Sauter2; Hartmut Schlüter1; 1UKE - Mass
Spec Proteomics, Hamburg, Germany; 2UKE - Institute
of Pathology, Hamburg, Germany; 3UKE - Martini-Clinic,
Hamburg, Germany; 4Steinbeis Innovation Center SCiLS,
Bremen, Germany; 5Bruker Daltonik, Bremen, Germany;
6
University of Hamburg - Inst. of Organic Chemistry,
Hamburg, Germany
Spatially Dependant Lipidomic Changes Associated
with Non-alcoholoic Fatty Liver Disease (NAFLD)
Visualized by MALDI IMS; Nick Bond1; Yajing Chu2;
Scarlet Brockmoeller2; Julian Griffin1, 2; Albert Koulman1;
1
HNR MRC, Cambridge, England; 2Dept. Biochemistry and
CSBC, Uni. of Cambridge, Cambridge, England
A Novel Combined DESI MSI/MAS NMR Approach to
the Diagnosis and Characterization of Breast Cancer
Tissue; Sabine Guenther; Stefan Antonowicz; Rathi
Ramakrishnan; Kirill A Veselkov; Laura Muirhead; Robert D
Goldin; Zoltan Takats; Imperial College London, London, UK
DESI-MS Imaging of Lipids and Metabolites in Cancers
Activated by the MYC and RAS Oncogenes; Livia S.
Eberlin; Emelyn H. Shroff; Jialing Zhang; David I. Bellovin;
Robert Tibshirani; Dean W. Felsher; Richard N. Zare;
Stanford University, Stanford, CA
Biomarker Discovery and Validation: Coupling MALDI
Imaging to Proteomic Expression and Metabolite
Quantitation to Characterize Radiation-Induced Tissue
Damage; Jace W. Jones1; Alison J. Scott1; Young Ah Goo1;
Artur Plett2; Christie M. Orschell2; David R. Goodlett1;
Robert K. Ernst1; Maureen A. Kane1; 1University of
Maryland, Baltimore, MD; 2Indiana University, School of
Medicine, Indianapolis, IN
Lipids General, 207 - 220

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Inter and Intra-Molecular Gas Phase Photo-Induced
Cross Linking of Triacylglycerol Lipid Ions; Shuai Nie;
Michigan State University, East Lansing, MI
Statistical Analysis of MALDI-ToF Mass Spectra from
Different Blood Components; Rory T. Steven; Alan M.
Race; Andrew D. Palmer; Joscelyn Sarsby; Rian L. Griffiths;
Ata Kaban; G. Ed. Rainger; Josephine Bunch; University of
Birmingham, Birmingham, UK
MALDI-MS Imaging of Cardiolipins in Rat Organ
Sections; Hay-Yan J. Wang 1; Hsuan-Wen Wu1; Ping-Ju
Tsai2; Cheng Bin Liu1, 3; 1National Sun Yat-Sen University,
Kaohsiung, Taiwan; 2Yuan’s General Hospital, Kaohsiung,
Taiwan; 3Veterans General Hospital-Kaohsiung, Kaohsiung,
Taiwan

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A Simple MALDI MS-based Method to Detect
Plasmalogens in Complex Lipid Mixtures - The Use of
2,4-Dinitrophenylhydrazine as Reactive Matrix; Beate
Fuchs; Juergen Schiller; University of Leipzig, Leipzig,
Germany
Ultra-Performance Liquid Chromatography-Tandem
Mass Spectrometry Method for Lipid Profiling of
Diabetic Rats Treated with Hepatoselective Glucokinase
Activators; Nicholas B. Vera; Pfizer, Cambridge, MA
Imaging Lipidomics by Microextraction Shotgun MS
and nano-LCMS of Brain Tissue Sections ; Reinaldo
Almeida; Zane Berzina Berzina; Hans Kristian HannibalBach; Christer Ejsing; University of Southern Denmark,
Odense, Denmark
Sphingolipid Profiling of AdiposeTissue: Specific
Overexpression of Ceramidase Improves Whole Body
Glucose and Lipid Metabolism; William L. Holland1, 2;
Yukiko Miyauchi1, 2; Ruth Gordillo1, 2; Philipp E. Scherer1, 2;
1
UTSouthwestern Medical Center, Dallas, TX; 2Touchstone
Diabetes Center, Dallas, TX
Lipids Analysis by 2 Dimensional LC Coupled to Triple
Quadrupole Mass Spectrometer; Liling Fang1; Taku
Tsukamoto2; Jing Dong2; Keiko Yamabe2; Takashi Suzuki2;
Yoshihiro Hayakawa2; 1Shimadzu Scientific Instruments,
Inc., Columbia, MD; 2Shimadzu Corporation, Kyoto, Japan
High Throughput Data Independent Approach for
Qualitative and Quantitative Lipidomic Analysis;
Xu Wang1; Michael Kiebish2; Brigitte Simons1; John
McNamara1; Christie Hunter1; 1AB SCIEX, Framingham,
MA; 2Berg Diagnostics, Natick, MA
Targeted Lipidomics Identifies Interaction of
Sphingolipid Metabolism and Fatty Acid Elongation
In The Development of Diabetic Retinopathy; Todd A.
Lydic; Matthew Faber; Svetlana Bozack; Louis Glazer;
Susanne Mohr; Julia V. Busik; Gavin E. Reid; Michigan
State University, East Lansing, MI
Robust Lipid Fragmentation Modeling to Identify
Global Lipid Changes during Epithelial-Mesenchymal
Transition (EMT); Brendan Coutu; Kristin Alexander; Marc
Hansen; John Prince; Brigham Young University, Provo, UT
Metabolism and Protein Adduction of a
Cyclooxygenase-2/15-prostaglandin Dehydrogenase
Derived Product from Arachidonic Acid; Nathaniel W.
Snyder; Alejandro D. Arroyo; Xiaojing Liu; Suhong Zhang;
Ian A. Blair; University of Pennsylvania, Philadelphia, PA
Profiling of Triacylglycerides Present in Edible Oils
Consumed in India Using LC/MS/MS; Deepti Bhandarkar;
Shruti Raju; Shailesh Damale; Shailendra Rane; Rashi
Kochhar; Ajit Datar; Pratap Rasam; Jitendra Kelkar;
Shimadzu Analytical (India) Pvt. Ltd., Andheri (E), Mumbai,
Maharashtra, India
Optimization of Supercritical Fluid Chromatography
Coupled to Mass Spectrometry for Lipid Analysis; Marie
Méjean; Alain Brunelle; David Touboul; ICSN, CNRS, Gifsur-Yvette, France

Lipids: Identification and Structural Analysis, 221 - 232
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Surface Oxidation under Ambient Air - A Fast and
Economical Method to Identify Double Bond Positions
in Unsaturated Lipids; Hyejung Park1; Ying Zhou1;
Philseok Kim2; Yan Jiang1; Catherine Costello1; 1Boston
University School of Medicine, Boston, MA; 2Harvard
University, Cambridge, MA
One-step Reversed Phase Liquid Chromatography
Coupled to ESI Mass Spectrometry for Separation,
Detection of Polar Lipids Associated with Prion
Proteins; Ying Zhou1; Holger Wille3; Hyejung Park1; Julian

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ollesch2; Catherine E Costello1; 1Boston University School
of Medicine, Boston, MA; 2Ruhr-Universitaet Bochum,
Bochum, Germany; 3University of Alberta, Edmonton,
Alberta, Canada
Enabled by Speed of Analysis: Multidimensional LCMS-Based Lipidomics; Susanne Brodesser1; Axel Besa2;
1
CECAD Lipidomics Facility, Cologne, Germany; 2AB SCIEX
Europe, Darmstadt, Germany
New Retroactive Approach for Global Lipidomics
Analysis by Data Independent Acquisition; Kazutaka
Ikeda; Sanae Yamanaka; Masaru Tomita; Tomoyoshi Soga;
Keio Universiy, Tsuruoka, Japan
Ultra-High Resolution Analysis of Triacylglycerol
in Seed Oils Using a High-Performance Orbitrap
Hybrid and Automated Data Processing Software;
Jeffrey Gilbert1; Debbie Schwedler1; Scott Greenwalt1;
Brita McNew1; Daniel Gachotte1; Mary Evenson1; Yasuto
Yokoi2; Tim Stratton3; David Peake3; 1Dow AgroSciences,
Indianapolis, IN; 2Mitsui Knowledge Industry, Tokyo, Japan;
3
Thermo Fisher Scientific, San Jose, CA
Analysis of Isolevuglandin/Isoketal Lysine Adducts
Using a Traveling Wave Ion Mobility Time-of-Flight
Mass Spectrometer; Lin Huang; Jaewoo Choi; Samanthi
Wickramasekara; Claudia Maier; Oregon State University,
Corvallis, OR
Identification and Characterization of Endogenous
and Novel Cardiolipins in Human Serum; Elizabeth
W. Kahuno; Feng-Ying C. Lin; Alfred L. Yergey; Peter S.
Backlund; NICHD, NIH, Bethesda, MD
A Shotgun Lipidomics Approach Coupled with Charge
Switch Derivatization Applied to Identification and
Quantitation of Fatty Acid Double Bond Isomers;
Kui Yang; Beverly Gibson Dilthey; Richard W. Gross;
Washington University School of Medicine, St. Louis, MO
Rapid Characterization of Phospholipid Isomeric
Mixtures from Sample Arrays and Tissue Sections By
Sequential Collision-Induced Dissociation and OzoneInduced Dissociation; Rachel L. Kozlowski; Todd W.
Mitchell; Stephen J. Blanksby; University of Wollongong,
Wollongong, Australia
Analysis of Phosphocholines Using Metastable Atom
Activated Dissociation Mass Spectrometry (MAD-MS)
and Collision Induced Dissociation (CID); Robert E.
Deimler1; Madlen Sander2; William D. Hoffmann1; Glen
P. Jackson1; 1West Virginia University, Morgantown, WV;
2
Leipzig University, Leipzig, Germany
High Resolution 193 nm UVPD-MS for the Topdown Structural Characterization of Lipid A and
Lipopolysaccharides; John O’Brien; Brittany Needham;
Jeremy Henderson; M. Stephen Trent; Jennifer Brodbelt;
University of Texas, Austin, TX
Characterization and localization of d18:2
Sphingadienine Based Sulfatides in Rat Cerebellum
Using 2D Offline LC-HRMS and MALDI Imaging; Benoit
Colsch 1; Samia Boudah1, 3; Christophe Junot1; Amina S.
Woods2; 1CEA, DSV/iBiTec-S/SPI/LEMM, Gif sur Yvette,
France; 2NIDA/NIH, Baltimore, MD; 3GlaxoSmithKline,
Centre de recherche F. Hyafil, Villebon-sur-Yvette, France

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Nucleic Acids: General, 233 - 250
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Biomolecule-Ligand Noncovalent Complexes:
Mass Spectrometry as a Key to Interpret Solution
Fluorescence Data; Daisuke Miyoshi2; Adrien Marchand3,
3
; Valerie Gabelica1, 3; 1University of Liège, Liège, Belgium;
2
FIBER & FIRST, Konan University, Kobe, Japan;
3
University of Bordeaux, Pessac, France

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A Mass Spectrometry-based Method for the
Identification of Novel G-Quadruplex-binding Proteins;
Preston Williams; Xiaoli Dong; Yinsheng Wang; University
of California, Riverside, CA
Disclosure High Affinity Binding Ligands to Human
Telomeric RNA G-quadruplexes by Electrospray
Ionization Mass Spectrometry; Jiang Zhou; Xiaojie Cui;
Qiang Zhang; Gu Yuan; College of Chemistry, Peking
University, Beijing, China
Probing Aptamer-Ligand Interactions Using Soft
Ionization Mass Spectrometry Methods; Basri Gulbakan;
Fan Chen; Konstantin Barylyuk; Renato Zenobi; ETH
Zurich, Zurich, CH
Rapid and High-Confidence Sequence Confirmation of
Modified Oligonucleotides Using High Resolution Mass
Spectrometry; Sudong Kong1; Jianlan Yu2; Wenhai Jin2; Ji
Luo2; Yongming Xie2; 1Suzhou Ribo Life Science Co.,Ltd,
Suzhou, Jiangsu Province, China; 2Asia Pacific Application
Support Center, AB SCIEX, Shanghai, China
HPLC-ESI+-MS/MS Analysis of DNA Adducts
of Phosphoramide Mustard, Metabolite of
Cyclophosphamide, in Human Peripheral Blood
Lymphocytes and HapMap Cells; Teshome Gherezghiher;
Kinjal Sanghavi; L’Aurelle Johnson; Jatinder Lamba;
Jacobson Pamala; Natalia Tretyakova; University of
Minnesota, Minneapolis, MN
Active Turnover of DNA Methylation and
Hydroxymethylation Measured by LC-ESI-MS/MS-MRM;
Thuc Le; Guoping Fan; Kym Faull; UCLA, Los Angeles, CA
Quantification of 8,5’-cyclopurine-2’-deoxynucleosides
Induced by Fenton-like Reagents; Candace Guerrero;
Yinsheng Wang; UC Riverside, Riverside, CA
Replication Studies of Ethylated Thymidine Adducts
in vitro and in vivo; Nisana Andersen; Pengcheng Wang;
Qianqian Zhai; Yinsheng Wang; UC Riverside, Riverside,
CA
Quantitative Analysis of Tet-induced Oxidation
Products of 5-Methylcytosine in Human Cells and
Mammalian Tissues; Yinsheng Wang; Shuo Liu; University
of California, Riverside, CA
Quantification of 1,3-Butadiene-Induced DNA Adducts
in Human Blood Using Liquid Chromatography- High
Resolution Tandem Mass Spectrometry (LC-HRMS/
MS-SRM); Dewakar Sangaraju1; Peter Villalta1; Melissa
Goggin2; Maria Agunsoye1; Colin Campbell1; Natalia
Tretyakova1; 1University of Minnesota, Minneapolis, MN;
2
MEDTOX Scientific, Minneapolis, MN
Isolation and Analysis of Oligonucleotide Metabolites
from Various Tissues by LC/MS; Jason Anspach1; Michael
Mcginley1; Jeff Layne1; Mark Hail2; 1Phenomenex, Torrance,
CA; 2Novatia LLC, Monmoutht Junction, NJ
Quantitatitive Analysis of Phosphorothioate
Oligonucleotide in Human Plasma Using LC-MS/MS
with On-Line Extraction; Laixin Wang; Sherry Liu; Qiuying
Zhu; Scott Reuschel; Min Meng; Tandem Labs, Salt Lake
City, UT
LC-MS/MS Structural Characterization of the Impurities
in Synthetic Phosphorothioate Oligonucleotides:
Current Challenges and Future Solutions; Lianming Wu;
GlaxoSmithKline, King Of Prussia, PA
Suppression of Photo-Dissociation of Black Hole
Quencher labels of PCR Probes during MALDI MS
Analysis; Igor Smirnov; Galina Pozmogova; Institute of
Physico-Chemical Medicine, Moscow, Russian Federation

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POSTERS
GENERAL
INFORMATION

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Advantages and Disadvantages Between Two
Approaches to Quantitate Oligonucleotides in
Various Matrices with Liquid Chromatographic Mass
Spectrometer; Jiongwei Pan; Jeffrey Selenka; Steven
Becht; PPD, Middleton, WI
OMA and OPA – A Software Tool for Mass Spectra
Analysis of Natural and Modified Nucleic Acids; Silvan
R. Stucki1; Adrien Nyakas1; Lorenz C. Blum2; Jean-Louis
Reymond1; Stefan Schürch1; 1University of Bern, Bern,
Switzerland; 2ETH Zürich, Zürich, Switzerland
GenoMass: An Automated Tool for the Computational
Interpretation of the LC-MS/MS Data of Modified
Oligonucleotides to Perform Online Sequencing; Vaneet
K Sharma1; Joshua Klaene1; Qing Liao2; James Glick1; Paul
Vouros1; 1Northeastern University, Barnett Institute, Boston,
MA; 2Shenitech LLC, Acton, MA
Nucleic Acids: RNA, 251 - 262

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High Throughput Analysis of LC-MS Datasets from
Isotopically Labeled RNA; Siwei Li; Patrick Limbach;
University of Cincinnati, Cincinnati, OH
Identifying the Anticodons of Thermus thermophilus
tRNAs Asn, Asp, His, and Tyr Using LC-MS/MS; Robert
Ross; Patrick Limbach; University of Cincinnati, Cincinnati, OH
Mass Spectral Analysis of Modified Nucleosides and
Nucleoside Monophosphates; Kirk Gaston; Patrick
Limbach; University of Cincinnati, Cincinnati, OH
Method for Pseudouridine Detection and Quantification
in RNA by Chemical Derivatization and Tandem Mass
Spectrometry; Balasubrahmanyam Addepalli; Patrick
Limbach; University of Cincinnati, Cincinnati, OH
A Study to Sequence and Characterise Isobaric
RNAs Using Tandem Mass Spectrometry and Ion
Mobility Spectrometry-Mass Spectrometry; Henry
Fisher1; Marco Smith2; Alison E Ashcroft1; 1Faculty of
Biological Sciences,University of Leeds, Leeds, UK;
2
GlaxoSmithKline, Stevenage, UK
Direct Identification and Characterization of microRNAs
by Liquid Chromatography – High-Resolution Tandem
Mass Spectrometry and Database Searching; Hiroshi
Nakayama1, 2; Yoshio Yamauchi2, 3; Masato Taoka3; Yuko
Nobe2; Toshiaki Isobe2, 3; 1RIKEN Advanced Science
Institute, Saitama, Japan; 2CREST, JST, Saitama, Japan;
3
Tokyo Metropolitan University, Tokyo, Japan
Liquid Chromatography-Mass Spectrometry-Based
Characterization of Pseudouridine in Non-Coding
RNAs at Single Nucleotide Resolution; Masato Taoka1;
Yuko Nobe1; Aiko Takeuchi1; Hiroshi Nakayama2, 3; Yoshio
Yamauchi1; Toshiaki Isobe1, 3; 1Department of Chemistry,
Tokyo Metropolitan Univ., Tokyo, Japan; 2RIKEN Advanced
Science Institure, Wako, Japan; 3CREST, JST, Tokyo, Japan
Determination of the Metabolic Stability of siRNA Using
LC-MS; A. Cary McGinnis; Michael Bartlett; University of
Georgia, Athens, GA
Development of a LC-MS/MS Method for Detection and
Quantitation of siRNA as Therapeutic Candidates in
Rat and Monkey Plasma; Suzie Yeh; Rena Zhang; Mark
Cancilla; BaoJen Shyong; Edward Carlini; Merck & Co.,
Inc., West Point, PA
Detecting Nucleoside Post Enzymatic Cleavage
Modifications in RNA Using Fast Precursor Scanning
and Fast Polarity Switching Triple Quadrupole Mass
Spectrometry; Susan Leonard1; Jonathan Ho2; Peter
Ratsep2; Nicholas Cobb1; 1Shimadzu Scientific Inst,
Marlborough, MA; 2Shimadzu Scientific Instruments,
Somerset, NJ

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Advancing the Development of RNA Therapeutics with
Innovative Mass Spectrometry Based Assays; BaoJen
Shyong; Christopher Kochansky; Tracy Young; Suzie Yeh;
Rena Zhang; Charles Thompson; Mark Cancilla; Merck,
West Point, PA
LC-MS Methods for Identification and Quantitation
of microRNA; Majlinda Kullolli; Sharon Pitteri; Stanford
University, Palo Alto, CA
Instrumentation: New Developments in
Ionization and Sampling, 263 - 293

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The Capillary Gap Sampler: a New Microfluidic Platform
Directly Coupled to ESI-MS for Fast Analysis of Low
Sample Amounts; Volker Neu1; Roger Steiner2; Stephan
Müller2; Christof Fattinger2; Renato Zenobi1; 1ETH Zurich,
Zurich, CH; 2F. Hoffmann-La Roche AG, Discovery
Technolgies, Basel, CH
A Comparative Forensic Study Comparing the
Newly Discovered Electrospray Inlet Ionization with
Electrospray Ionization; Lyla Hassan; Dr. Charles
McEwen; University of the Sciences, Philadelphia, PA
Electro-Thermal Vaporizer (ETV) Direct Analysis in Real
Time-Mass Spectrometry (DART-MS) For Sensitive
and High Throughput Water Contaminant Analysis;
Prabha Dwivedi1; Daniel Gazda2; William Wallace2; Thomas
Limero2; Ariel Macatangay3; Facundo Fernandez1; 1Georgia
Inst. of Technology, Atlanta,; 2NASA-JSC/SK4/Wyle Sc.,
Tech., and Eng. Group, Houston, TX; 3NASA-JSC/SF4,
Houston, TX
Improved LC-DART-MS Interface for Reaction
Monitoring and Impurity Analysis in non-ESI-Friendly
Solvents; Adam Kaylor1; Prabha Dwivedi1; Guilong Cheng2;
Facundo Fernandez1; 1Georgia Institute of Technology,
Atlanta, GA; 2Pfizer Analytical R&D, Pharmaceutical
Science, Groton, CT
Effective Ion Transmission Scheme for Ambient
Plasma-based Discharge Sources Coupled with Drift
Tube Ion Mobility Spectrometry; Joel Keelor; Prabha
Dwivedi; Facundo Fernandez; Georgia Institute of
Technology, Atlanta, GA
A Novel Radiofrequency Ionization Method for
the Analysis of Wide Classes of Volatile Organic
Compounds; Touradj Solouki; Behrooz Zekavat; Abayomi
Olaitan; Baylor University, Waco, TX
Analysis of Volatile Organic Compounds in Gasoline
Samples Using Radio-Frequency Ionization/Mass
Spectrometry; Behrooz Zekavat; Abayomi Olaitan; Touradj
Solouki; Baylor University, Waco, TX
Characterisation and Performance of a Glow Discharge
as a Source of Electrons for a Portable Mass
Spectrometer; Achouak Chalkha1; Aurika Janulyte1; Yves
Zerega1; Boris Brkić2; Steve Taylor2; Jacques Andre1; 1AixMarseille Université, Marseille, France; 2Dpt Elec Eng &
Electronics University of Liverpool, Liverpool, UK
Cool Down, Relax, Enjoy the Ride. An Ion Energy Study
for a Funnel Interface of a Triple Quad; Felician Muntean;
Maurizio Splendore; Desmond Kaplan; Stephen Zanon;
Steve Schachterle; Roy Moeller; Bruker Daltonics, Fremont,
CA
Towards Nanoscale Spatially Resolved Surface
Enhanced Laser Desorption/Ablation Chemical
Profiling via Mass Spectrometry; Deepak Bhandari; Ivan
Kravchenko; Olga Ovchinnikova; Gary Van Berkel; Oak
Ridge National Laboratory, Oak Ridge, TN

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MONDAY POSTERS

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The Use of Theta Glass Capillaries for Wire-in-aCapillary Nano-Electrospray Mass Spectrometry to
Facilitate In-Line Solution Mixing; Christine Fisher;
Anastasia Kharlamova; Scott McLuckey; Purdue University,
West Lafayette, IN
A Novel Corona Discharge Source with Liquid
Point Electrode; Sonja Klee; Marco Thinius; Valerie
Derpmann; Walter Wißdorf; Sebastian Klopotowski; Klaus
J. Brockmann; Thorsten Benter; University of Wuppertal,
Wuppertal, Germany
GC Performance of a Novel Capillary Atmospheric
Pressure Chemical Ionization (cAPCI) Source; Sonja
Klee; Dennis Klink; Marco Thinius; Yessica Brachthäuser;
Thorsten Benter; University of Wuppertal, Wuppertal,
Germany
Spark Discharge VUV Lamps for Atmospheric Pressure
Ionization – Mass Spectrometric Investigations of
the Plasma Chemistry; Hendrik Kersten; Ian Barnes;
Sebastian Klopotowski; Thorsten Benter; University of
Wuppertal, Wuppertal, Germany
Progress in the Development of Capillary Atmospheric
Pressure Electron Capture Ionization (cAPECI); Valerie
Derpmann; David Müller; Thorsten Benter; University of
Wuppertal, Wuppertal, Germany
Charging Effects in Ion Transfer Capillaries: An InDepth Study; David Müller; Valerie Derpmann; Thorsten
Benter; University of Wuppertal, Wuppertal, Germany
SimBlend - an Open Source Visualization Tool Chain
for SIMION; Dominik Sand; Klaus J. Brockmann; Walter
Wißdorf; Thorsten Benter; University of Wuppertal,
Wuppertal, Germany
Field Driven Chemical Effects in API: Numerical
Modeling of the Ion Temperature at Atmospheric
and Intermediate Pressure with SIMION-RS; Walter
Wißdorf1; Yessica Brachthäuser1; Christine Polaczek1;
Philipp Cochems2; Stefan Zimmermann2; Thorsten Benter
1 1
; University of Wuppertal, Wuppertal, Germany; 2Leibniz
University Hannover, Hannover, Germany
Visualization and Optimization of the Fluid Dynamics
in High-Flow Atmospheric Pressure Ion Sources, Using
the Background Oriented Schlieren Method (BOS);
Sebastian Klopotowski; Alexander Haack; Thorsten Benter;
University of Wuppertal, Wuppertal, Germany
An API MS for Mechanistic Studies of Ion-Clusters
Formation in the Gas Phase; Sascha Albrecht2; Fred
Stroh2; Jochen Barthel2; Armin Afchine2; Sonja Klee1;
Thorsten Benter 1; 1University of Wuppertal, Wuppertal,
Germany; 2Research Center Jülich, Jülich, Germany
Development of an Ion Funnel Based on Printed Circuit
Technology for Ion Transfer and Ion Manipulation
Purposes; Albrecht Brockhaus; Sonja Klee; Walter
Wißdorf; Klaus J. Brockmann; Thorsten Benter; Albrecht
Glasmachers; University of Wuppertal, Wuppertal, Germany
Progress in the Development of Capillary Atmospheric
Pressure Ionization Methods (cAPI); Sonja Klee; Valerie
Derpmann; Hendrik Kersten; Walter Wißdorf; David Müller;
Yessica Brachthäuser; Sebastian Klopotowski; Klaus
Brockmann; Thorsten Benter; University of Wuppertal,
Wuppertal, Germany
Development of a Dielectric Barrier Discharge
Ionization Source for Vapors Analysis; Trent Hammer; Dr
Rob O’Brien; UBC Okanagan, Kelowna, Canada
Performance Determination of a Novel Liquid
Calibration Unit Utilizing Proton-Transfer-Reaction
Mass Spectrometry (PTR-MS); Lukas Fischer1; Jens
Herbig1; Alfons Jordan2; Lukas Märk2; Andreas Klinger1;
Klaus Winkler1; Rene Gutmann1; Armin Hansel1, 3; Tilmann

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D. Märk2, 3; 1IONIMED Analytik, Innsbruck, Austria;
2
IONICON Analytik, Innsbruck, Austria; 3University of
Innsbruck, Innsbruck, Austria
Exploring the Capabilities and Specificities of CESIMS for Bottom-Up Proteomics and Peptide Mapping
of Proteins through a Comparison to NanoLC; JeanMarc Busnel1; Dona Neloni Wijeratne1; Anna Lou1; Chitra
Ratnayake1; Sean Seymour2; Christie Hunter2; 1Beckman
Coulter, Brea, CA; 2AB Sciex, Foster City, CA
Detection of a Low-Volatility Analyte Vapor Permeating
a Polymer Membrane; Bruce Salter1; Derek Lovingood3;
Jeffery Owens2; 1Universal Technology Corporation, Tyndall
AFB, FL; 2Air Force Research Laboratory, Tyndall AFB, FL;
3
Oak Ridge Institute for Science and Education, Oak Ridge,
TN
The Design and Characterization of a Novel Ultralow Flow Nanoelectrospray Device for Metabolite
Quantitation; Benjamin Ngo1; Shaoxia Yu2; Ling Xu2;
Swapan Chowdhury2; Jing-Tao Wu2; Mike S. Lee3; Gary
Valaskovic1; 1New Objective, Inc., Woburn, MA; 2Millennium
Pharmaceuticals, Cambridge, MA; 3Milestone Development
Services, Newton, PA
Characterization of a Low-Power, Pressure-Tolerant
Microionizer; Craig Cavanaugh1; Kenion Blakeman1; Tina
Stacy1; Derek Wolfe1; Stanley Pau2; J Michael Ramsey1;
1
UNC - Chapel Hill, Durham, NC; 2University of Arizona,
Tuscon, AR
Microfluidic Chip for the Separation and Identification
of Proteins Using Dynamic Isoelectric Focusing
Coupled to MALDI Mass Spectrometry (DIEF-MALDIMS); Srikanth Akinapalli; Shannon Wilson; Luke Tolley;
Gary R. Kinsel; Southern Illinois University Carbondale,
Carbondale, IL
The Development of Matrix Assisted Ionization Vacuum
(MAIV) Mass Spectrometry (MS) for the Characterization
of Fragile Ganglioside Lipids; Steven Lingenfelter1;
Daniel Green1; James Wager-Miller2; Ken Mackie2; Sarah
Trimpin1; 1Wayne State University, Washington, MI; 2Indiana
University, Bloomington, IN
Characterization of a Low Pressure Nano-electrospray
Source for High Ion Current Applications; Christopher
Taormina; Randall Pedder; Ardara Technologies, Ardara, PA
Instrumentation: New Developments in
Mass Analyzers, 294 - 329

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Multiple Mass Analysis Using an Ion Trap Array
(ITA) Mass Analyzer; Yu Xiao; Chuan-Fan Ding; Fudan
University, Shanghai, China
Theoretical Modeling of Space Charge Effects in
Quadrupole Ion Traps; Dan Guo1; Yuzhuo Wang1; Hua
Zhang2; Xiaohua Zhang2; Xiang Fang3; Wei Xu1; 1Beijing
Institute of Technology, Beijing, China; 2Beijing Purkinje
General Instrument Co.,Ltd, Beijing, China; 3National
Institute of Metrology, Beijing, China
The Coupling Effects of Hexapole and Octopole Fields
in Quadrupole Ion Traps; Yuzhuo Wang1; Zejian Huang2;
You Jiang2; XingChuang Xiong2; Xiang Fang2; Wei Xu1;
1
Beijing Institute of Technology, Beijing, China; 2National
Institute of Metrology, Beijing, China
Design and Performance of a Prototype Miniature Triple
Quadrupole Mass Spectrometer; Steven Wright1; Andrew
Malcolm1; Christopher Wright1; Shane O’ Prey1; Neil Dash1;
Edward Crichton1; Richard Moseley1; Wojciech Zaczek1;
Richard Syms2; Peter Edwards1; 1Microsaic Systems plc,
Woking, UK; 2Imperial College, London, UK

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Development of a Frequency-Scanned Quadrupole
Mass Filter for Large Ions; Deven Shinholt; Staci Anthony;
Martin Jarrold; IU Chemistry Dept., Bloomington, IN
Increasing the Drive Frequency of a Microscale
Cylindrical Ion Trap for Improved High Pressure
Performance; Kenion Blakeman; J. Michael Ramsey;
University of North Carolina, Chapel Hill, NC
Effects of Elevated Pressure on the Secular
Frequencies of Ions in a Cylindrical Ion Trap; Andrew
Hampton; Kenion Blakeman; Bruno Coupier; Derek Wolfe;
J. Michael Ramsey; UNC - Chapel Hill, Chapel Hill, NC
GPU Accelerated High Pressure Simulation
Investigations in Miniature Ion Traps; Bruno Coupier;
Sorin Mitran; J. Michael Ramsey; UNC Chapel Hill, Chapel
Hill, NC
Characterization of a Novel Ion Trap Geometry
for Higher Capacity Trapping in Microscale Mass
Spectrometry; Kevin Schultze; J. Michael Ramsey;
University of North Carolina at Chapel Hill, Chapel Hill, NC
Miniature Cylindrical Ion Trap Geometry Optimization
and Parameter Scaling; Dmitriy Chernookiy; Bruno
Coupier; J. Michael Ramsey; University of North Carolina,
Chapel Hill, Chapel Hill, NC
Broadband MS/MS for Fast and Sensitive Targeted
Monitoring of Multiple Compounds in Ion Trap MS;
Alexander Misharin; Konstantin Novoselov; Victor Laiko;
Vladimir M. Doroshenko; MassTech, Columbia, MD
Performance of the Ceramic-Based Rectilinear Ion Trap
(cRIT) with Field-Adjusting Electrode (FAE); Fuxing Xu;
Liang Wang; Chuan-Fan Ding; Fudan University, Shanghai,
China
Dual-Polarity Ion Trap Mass Spectrometry:
Simultaneous Manipulation and Mass Analysis of
Positive and Negative Ions; Muyi He1; Lili Wei1; You
Jiang2; Xingchuang Xiong2; Zejian Huang2; Xiang Fang2;
Wei Xu1; 1Beijing Institute of Technology, Haidian District,
China; 2National Institute of Metrology, Beijing, China
Utilizing a Collision Cell with Axial Field for Achieving
Ultra High Speed SRM in a Triple Stage Quadrupole
Mass Spectrometer; Oleg Silivra; Harald Oser; Terry
Olney; Thermo Fisher Scientific, San Jose, CA
Design of a Prototype Digital Ion Trap for High
Resolution Ion Trap Mass Analysis; Di Wang1; Theresa
Evans-Nguyen2; Friso Amerom3; 1Johns Hopkins University,
Baltimore, MD; 2Draper Laboratory, Tampa, FL; 3Mini-Mass
Consulting, St. Pete Beach, FL
Automatic Isotope Ratio Optimization on High-Field
Orbitrap Mass Analyzers; Jesse D. Canterbury1; Philip
Remes1; Michael W. Senko1; Eduard Denisov2; Alexander
Makarov2; 1Thermo Fisher Scientific, San Jose, CA;
2
Thermo Fisher Scientific GmbH, Bremen, Germany
Multi-electrode Electrostatic Trap with QuadroLogarithmic Potential Distribution: Computer
Modeling of Instrument Performance; Gleb Vladimirov1;
Eugene Nikolaev2, 3; 1Institute for Energy Problems of
Chemical Physics, Moscow, Russia; 2Emanuel Institute
of Biochemical Physics, Moscow, Russia; 3Orekhovich
Institute of Biomedical Chemistry, Moscow, Russia
Extending the Upper Mass Limit of Orbitrap Mass
Spectrometry; Philip D. Compton1; Eugen Damoc2;
Eduard Denisov2; Alexander Makarov2; Neil L. Kelleher1;
1
Northwestern University, Evanston, IL; 2Thermo Fisher
Scientific, Bremen, Germany
Development of a Novel Harmonic Oscillator Ion Trap
Mass Spectrometer Based on a Multi-Potential Ion
Guide (MPIG); Curtiss Hanson; University of Northern
Iowa, Cedar Falls, IA

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Improving the Accuracy and Limits of Detection for
Charge Detection Mass Spectrometry; Nathan C.
Contino; Elizabeth E. Pierson; David Z. Keifer; Martin F.
Jarrold; Indiana University, Bloomington, IN
Charge Sensitive Superconducting Nano-Strip Ion
Detector for Time-Of-Flight Mass Spectrometry;
Nobuyuki Zen1; Shigetomo Shiki1; Koji Suzuki1; Masahiro
Ukibe1; Masaki Koike1; Roberto Cristiano2; Masataka
Ohkubo1; 1AIST, Tsukuba, Japan; 2CNR, Napoli, Italy
Sensitivity Improvement of MCP-based Ion Detectors
for Mass Spectrometry; Etsuo Iizuka; Toshiyuki Uchiyama;
Masahiro Hayashi; Hamamatsu Photonics KK., Iwata-City,
Shizuoka-Pref., Japan
Ion Mobility Measurements within Fourier Transform
Ion Cyclotron Resonance Cells and Orbitraps; Yi Xin1;
Yu Chen1; Xiang Fang2; Wei Xu1; 1Beijing Institute of
Technology, Beijing, China; 2National Institute of Metrology,
Beijing, China
Performance of Popular ICR Cell Geometries: A
Simulated Expansion-Based Approach; Andriy
Kharchenko1, 2; Joshua Driver1; Ron Heeren2; Eugene
Nikolaev3; Jon Amster1; 1University of Georgia, Athens,
GA; 2FOM Institute for Atomic and Molecular Physics,
Amsterdam, Netherlands; 3Institute for Energy Problems of
Chemical Physics, Moscow, Russia
Improving Radial and Axial Uniformity of the Excitation
Electric Field in a Closed Dynamically Harmonized FTICR Cell; Tong Chen1; Nathan Kaiser2; Steve Beu3; Gregory
Blakney2; Christopher Hendrickson2; Alan Marshall1, 2;
1
Florida State University, Tallahassee, FL; 2National High
Magnetic Field Laboratory, Tallahassee, FL; 3S.C. Beu
Consulting, Austin, TX
Electrostatic Gimbal for Correction of Errors in Timeof-Flight Mass Spectrometers; John B Hoyes; Andrew
Whatley; David Langridge; Anthony Gilbert; Waters,
Manchester, UK
Design and Making of a Micro Time-Of-Flight Mass
Spectrometer Based on MEMS Technologies; Xavier
Machuron-Mandard; Charles-Marie Tassetti; Romain
Mahieu; Frederic Progent; Olivier Peyssonneaux; Laurent
Duraffourg; Jean-Sébastien Danel; Atomic Energy
Commission, Arpajon Cedex, France
Incorporation of a Radiofrequency Ion Funnel in Proton
Transfer Reaction - Time Of Flight - Mass Spectrometry;
Shane Barber1; Robert S Blake1; Iain R White1; Paul S
Monks1; Fraser Reich2; Steve Mullock2; Andrew M Ellis1;
1
University of Leicester, Leicester, UK; 2Kore Technology
Limited, Cambridgeshire, UK
Multi-Turn Time-of-Flight Mass Analyzers with
Rotational Symmetry and Open Trajectories; Vyacheslav
Shchepunov; Roger Giles; Shimadzu Research Laboratory
(Europe) Ltd., Manchester, UK
Advancements in Multi Reflecting High Resolution TOF
Mass Analyzers with Folded Flight Path; Viatcheslav
Artaev1; Mikhail Yavor2; Timofey Pomozov2; Anatoly
Verenchikov3; 1LECO Corporation, St. Joseph, MI; 2Institute
for Analytical Instrumention RAS, St. Petersburg, Russia;
3
MSC-CG, Bar, Montenegro
Multiple-Reflection Time-of-Flight Mass Spectrometers
for the Research With Exotic Nuclei and for Analytical
Mass Spectrometry; Wolfgang Plass1, 2; Timo Dickel1,
2
; Jens Ebert1; Johannes Lang1; Samuel Ayet2; Emma
Haettner1; Hans Geissel1, 2; Christian Jesch1; Wayne
Lippert1; Martin Petrick1; Christoph Scheidenberger1,
2
; Mikhail Yavor3; 1Justus-Liebig-Universität Gießen,
Gießen, Germany; 2GSI Helmholtzzentrum für

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Schwerionenforschung, Darmstadt, Germany; 3Institute for
Analytical Instrumentation, RAS, St. Petersburg, Russia
Optimization of Analytical Performances of
Synchronized Dual-Polarity MALDI-TOF Mass
Spectrometer for Fundamental Analysis; Hsun Lee;
Chih-Hao Hsiao; Yi-Sheng Wang; GRC, Academia Sinica,
Taipei, Taiwan
MS with 3D-reflective IO Subsystem; Yerbol
Sapargaliyev; Igor Spivak-Lavrov; Aldan Sapargaliyev;
REB, Almaty, Kazakhstan
Development of a Portable Mass Spectrometer for
Operation at 1 Torr; Feng Jin1; William D. Hoffmann1;
Guido F. Verbeck2; Glen P. Jackson1; 1West Virginia
University, Morgantown, WV; 2Department of Chemistry,
University of North Texas, Denton, TX
The New Vienna parallel DMA – An Ion Mobility Analyzer
System for High Molecular Mass Ions/Particles with
Improved Resolution; Peter Kallinger1; Victor Weiss2;
Günter Allmaier2; Wladyslaw Szymanski1; 1University of
Vienna, Vienna, Austria; 2Vienna University of Technology,
Vienna, Austria
Simulation of a Novel Two-Dimensional Mass
Separation Method Based on CCD Imaging of Spiral Ion
Patterns; Jens Langejuergen; Christian R. Raddatz; Stefan
Zimmermann; Leibniz University Hannover, Hannover, Germany

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Ambient Ionization: Instrumentation, 330 - 356
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Development and Performance Characterization of
a Personal Mass Spectrometry System; Linfan Li1;
Yue Ren1; Tsung-Chi Chen1; Ziqing Lin1; R. Graham
Cooks2; Zheng Ouyang1; 1Biomedical Engineering, Purdue
University, West Lafayette, IN; 2Department of Chemistry,
Purdue University, West Lafayette, IN
A Miniature Mass Spectrometer for in-situ and Realtime Chemical Analysis; Paul I. Hendricks1; Jacob T.
Shelley1, 2; Jon K. Dalgleish1; Jason S. Duncan3; Matt T.
McNicholas4; Linfan Li5; Tsung-Chi Chen5; Zheng Ouyang3,
5
; R. Graham Cooks1, 3; 1Dept. Chemistry Purdue University,
West Lafayette, IN; 2University of Muenster, Muenster,
Germany; 3Center for Analytical Instrument Development,
West Lafayette, IN; 4Department of Electrical and Computer
Engineering, West Lafayette, IN; 5Weldon School of
Biomedical Engineering, West Lafayette, IN
Electrospray/Plasma Ionization Mass Spectrometry
for Simultaneously Characterizing Polar and Nonpolar
Compounds; Sy-Chyi Cheng; Jentaie Shiea; National Sun
Yat-Sen Univ., Kaohsiung, Taiwan
Detecting Polar and Nonpolar Compounds by Impacting
Sample Surfaces with Reactive Species from Both ESI
and Plasma-APCI; Siou-Sian Jhang; Sy-Chyi Cheng; Jentaie
Shiea; National Sun Yat-Sen Univ., Kaohsiung, Taiwan
Laser Desorption Combined with Electrospray/Plasma
Ionization Mass Spectrometry for the Analysis of
Polymers and Proteins; Siou-Sian Jhang; Sy-Chyi Cheng;
Jentaie Shiea; National Sun Yat-Sen Univ., Kaohsiung, Taiwan
Electrospray Ionization Mass Spectrometry Combined
with High-Flow Fast Gas Chromatography for
Characterizing Mixtures of Organic Compounds; ChuNian Cheng; Jentaie Shiea; National Sun Yat-Sen Univ.,
Kaohsiung, Taiwan
Increasing Efficiency of Surface Acoustic Wave
Nebulization with an Ion Funnel; Mikhail Belov4; Yue
Huang1; lucas Monkonnen1; Scott Heron1, 2; J. Scott Edgar3;
Sung Hwan Yoon1, 2; David R. Goodlett 1, 2; 1University
of Washington, Seattle, WA; 2University of Maryland,

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Baltimore, MD; 3Deurion LLC, Seattle, WA; 4Spectroglyph
LLC, Richland, WA
Simply Applying Heat and/or Vacuum for Ionization of
Small and Large Nonvolatile Molecules for Use in MS
and Its Applications; Beixi Wang; Sarah Trimpin; Wayne
State University, Detroit, MI
Open Probe Supersonic Fast GC-MS – Real Time
Analysis with Separation; Alexander Fialkov; Aviv Amirav;
Uri Keshet; Mati Morag; Eli Flaxer; Tal Alon; Tel-Aviv
University, Tel-Aviv, Israel
Development of Sheath-Flow Probe Electrospray
Ionization (SF-PESI); Kenzo Hiraoka1; Md. Obaidur
Rahman1; Mridul Kanti Mandal1; Yasuo Shida1; Lee Chuin
Chen1; Satoshi Ninomiya1; Hiroshi Nonami2; 1University of
Yamanashi, Kofu, Japan; 2Ehime University, Matsuyama,
Japan
Fully Automated Liquid Microjunction Surface
Sampling-HPLC-MS/MS Analysis of Drugs and
Metabolites in Whole-Body Thin Tissue Sections; Vilmos
Kertesz1; Gary J. Van Berkel1; Paul Moench2; Alexandre
Catoire2; Adam Bentley2; Jimmy Flarakos2; 1Oak Ridge
National Laboratory, Oak Ridge, TN; 2Novartis Institutes for
BioMedical Research, East Hanover, NJ
Continuous Flow Liquid Microjunction Surface
Sampling Probe Connected On-line with HPLC/MS for
Spatially Resolved Analysis of Small Molecules and
Proteins; Gary J. Van Berkel; Vilmos Kertesz; Oak Ridge
National Laboratory, Oak Ridge, TN
Implementation of Ambient Ionization Sources on a
Low Cost GC/MSD and Assessment of Its Performance;
Joseph Tice1; Michael Festa1; Taylor Feraco1; Brian D.
Musselman 1; Randy Pedder2; John Mazock2; 1IonSense,
Inc., Saugus, MA; 2Ardara Technologies, Ardara, PA
Ultra-fast Analysis of Synthetic Organic Compounds
Using APGC without the C!; Peter Stokes; David Parker;
Jackie Mosely; University of Durham, Durham, UK
Low Temperature Plasma Ionization Mass Spectrometry
for Real-Time Analysis of Size-Selected Organic
Aerosol Particles; Sandra Spencer; Gary Glish; Univ. of
North Carolina at Chapel Hill, Chapel Hill, NC
Towards Micro Plasma Devices for Use in Ambient
Mass Spectrometry and 2D Chemical Imaging; Andrew
Bowfield; University of Liverpool, Liverpool, UK
A Compact, Robust and Light Weight Surface Ionization
Source; Vladimir Romanov; Jan Hendrikse; Smiths
Detection, Mississauga, Canada
Ultra-low Detection Limits for Trace Gas Analysis Using
a Tunable Non-radioactive Electron Emitter in APCI-MS;
Jens Langejuergen; Stefan Zimmermann; Leibniz University
Hannover, Hannover, Germany
Direct, Real-Time Vapor Detection of Low Volatility
Explosives; Robert Ewing; David Atkinson; Brian H.
Clowers; Pacific Northwest National Laboratory, Richland, WA
Development of a Piezoelectric Inkjet Dopant
Introduction Device for Atmospheric Pressure
Photoionization and Its Performance in Analysis
Polycyclic Aromatic Hydrocarbons; Ma’ an Amad; Salim
Sioud; Erqiang Li; Sigurdur Thoroddsen; King Abdullah
University of Science and Technology, Thuwal, Saudi Arabia
Detection of Naturally Occurring Flame Ions Using
a High-Temperatureatmospheric Pressure Interface;
Thomas Bierkandt1; Erdal Akyildiz1; Tina Kasper1; Stefan
Kaesdorf2; Ioannis Orfanopoulos3; Dimitris Papanastasiou3;
1
University of Duisburg-Essen, Duisburg, Germany;
2
Kaesdorf, Munich, Germany; 3Fasmatech, Athens, Greece

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Development of a New DIP-APCI Ion Source; Sonja
Krieger; Oliver J. Schmitz; University of Duisburg-Essen,
Essen, Germany
Atmospheric Pressure Laser Evaporation Ionization of
Levitated Droplets; Jens Riedel; Arne Stindt; Ulrich Panne;
BAM Federal Institute for Materials, Berlin, Germany
Analysis of Biomolecules by Atmospheric Pressure
Visible-Wavelength MALDI-ion trap-MS in Transmission
Geometry; Raymond West; Eric Findsen; Dragan Isailovic;
University of Toledo, Toledo, OH
Enhanced Direct Analysis of Biomedical Samples by
Laser Ablation Electrospray Ionization with Ion Mobility
Separation and Mass Spectrometry; Bindesh Shrestha;
Akos Vertes; George Washington University, Washington, DC
Laser Ablation Electrospray Ionization Mass
Spectrometry of Plant Cells in Transmission Geometry;
Rachelle Jacobson; Bindesh Shrestha; Akos Vertes;
George Washington University, Washington, DC
Peptides and Proteins Signal Enhancement in
Electrospray-Assisted Laser Desorption/Ionization
Mass Spectrometry by Black Oxide (Fe3O4) Coated
Target; Alexey Kononikhin1, 3; Min-Zong Huang2; Igor
Popov3, 4; Alexey Boldyrev4; Evgeny Kukaev3, 4; Alexander
Spassky1; Ilya Leipunsky1; Jentaie Shiea2; Eugene
Nikolaev1, 3; 1Institute for Energy Problems of Chemical
Physics, Moscow, Russia; 2National Sun Yat-Sen University,
Kaohsiung, Taiwan; 3Emanuel Institute of Biochemical
Physics, Moscow, Russia; 4Moscow Institute of Physics and
Technology, Moscow, Russia

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Informatics: General, 357 - 373
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GOAT: A Simple MS/MS Gradient Optimization and
Analysis Tool; David Trudgian1; Roman Fischer2; Xiaofeng
Guo1; Hamid Mirzaei1; 1UT Southwestern Medical Center,
Dallas, TX; 2University of Oxford, Oxford, UK
New Plug-ins for Freely Available Mass++ Software
to Identify Biomolecules; Kentaro Morimoto1; Takashi
Nishikaze1; Satoshi Tanaka1; Masaki Murase1; Shin-ichi
Utsunomiya1; Shigeki Kajihara1; Tsuyoshi Tabata2; Ken
Aoshima2; Yoshiya Oda2; Koichi Tanaka1; 1Shimadzu
Corporation, Kyoto, Japan; 2Eisai Product Creation
Systems, Eisai Corp., Tsukuba, Japan
Novel Preprocessing Method to Align Retention
Time of LC-MALDI and New Implemented Functions
in Mass++ for Differential Analysis; Yuichiro Fujita1;
Natsumi Funakoshi1; Yoshihiro Yamada1; Satoshi Tanaka1;
Shin-ichirou Kawabata1; Shinichi Iwamoto1; Shinichi
Utsunomiya1; Shigeki Kajihara1; Tsuyoshi Tabata2; Ken
Aoshima2; Yoshiya Oda2; Koichi Tanaka1; 1Shimadzu
Corporation, Kyoto, Japan; 2Eisai Product Creation
Systems Eisai Co., Ltd, Tsukuba, Japan
Mass++: A Platform for Mass Spectrometry to
Construct Suitable Software to Achieve User’s Own
Purposes; Shin-ichi Utsunomiya1; Satoshi Tanaka1;
Masaki Murase1; Shigeki Kajihara1; Tsuyoshi Tabata2;
Ken Aoshima2; Yoshiya Oda2; Koichi Tanaka1; 1Shimadzu
Corporation, Kyoto, Japan; 2Eisai Product Creation
Systems, Eisai Corp., Tsukuba, Japan
A Software Solution for Rapid Characterization of
Biologics; Xu Guo 1; Robert Deutschman2; Byung-Hee
Shin3; Eric Johansen2; 1AB SCIEX, Canada, Concord,
ON; 2AB SCIEX, USA, Foster City, CA; 3AB SCIEX, South
Korea, Seoul, South Korea
Building Proteomic Application Platforms for Cloud
Computing Environments with CloudBioLinux; John
Chilton1; Roman Zenka2; Pratik Jagtap1; Benjamin Lynch1;
Robert (Bob) Bergen2; Timothy Griffin3; 1University of

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Minnesota Supercomputing Institute, Minneapolis, MN;
2
Mayo Clinic, Rochester, MN; 3University of Minnesota,
Minneapolis, MN
Proteomics Pipeline Tracer Bullets; Roman Zenka;
Surendra Dasari; Carrie J. Heppelmann; Kenneth L.
Johnson; H. Robert Bergen, III; Mayo Clinic, Rochester, MN
Definitions of Terms Relating To Mass Spectrometry;
Kermit K. Murray1; Robert K. Boyd2; Marcos N. Eberlin3; G.
John Langley4; Liang Li5; Yasuhide Naito6; 1Louisiana State
University, Baton Rouge, LA; 2National Research Council,
Ottawa, Canada; 3Thomson Lab Unicamp, Campinas,
Brazil; 4University of Southampton, Southampton,
UK; 5University of Alberta, Edmonton, Canada; 6GPI,
Hamamatsu, Japan
A Flexible Platform for Automating Mass Spectrometry
Data Processing for Biotherapeutic Characterization;
Joe Shambaugh1; Alessio Ceroni1; Jessica Qi1; Jens
Hoefkens1; Steven Pomerantz2; 1Genedata Inc, Lexington,
MA; 2Janssen Research and Development, Radnor, PA
Sample Reproducibility and Statistical Significance in a
Nascent Microbial Community Proteomics Experiment;
Erik Hendrickson; Tony Wang; Murray Hackett; University of
Washington, Seattle, WA
Gene-based Protein Identification; Honglan Li1; Seungjin
Na2; Eunok Paek2; 1Soongsil University, Seoul, South
Korea; 2Hanyang University, Seoul, South Korea
Web Services for the Online NIST Libraries of Peptide
Tandem Mass Spectra; Niksa Blonder1; Manor Askenazi2;
Dmitrii Tchekhovskoi1; Yuri Mirokhin1; Paul Rudnick1;
Stephen Stein1; 1NIST, Gaithersburg, MD; 2The Ionomix
Initiative, Arlington, MA
BRAIN 2.0: Time and Memory Quasi-Constant
Algorithm for Calculating the Isotopic Distribution;
Piotr Dittwald1; Dirk Valkenborg2, 3; 1University of Warsaw,
Warszawa, Poland; 2VITO, Mol, Belgium; 3I-Biostat, Hasselt
University, Diepenbeek, Belgium
Galaxy-P: Transforming MS-based Proteomic
Informatics via Innovative Workflow Development,
Dissemination, Standardization and Transparency;
Timothy Griffin1; John Chilton2; James Johnson2; Ebbing
de Jong1; Getiria Onsongo2; Pratik Jagtap2; 1University
of Minnesota, Minneapolis, MN; 2University of Minnesota
Supercomputing Institute, Minneapolis, MN
Statistical Model for Alignment of Open Platform
Proteomics Data - Incorporating Ion Mobility Separation
and Product Ions; Ashlee Benjamin; Will Thompson;
Erik Soderblom; M Arthur Moseley; Joseph Lucas; Duke
University, Durham, NC
Molecular Isotopic Distribution Analysis (MIDAs)
with Adjustable Mass Accuracy; Gelio Alves; Aleksey
Ogurtsov; Yi-Kuo Yu; National Center for Biotechnology
Information, NLM, Bethesda, MD
Trans-Proteomic Pipeline Tools for the Analysis of MS/
MS Proteomics Data in Conjunction with Matching
RNA-seq Data; Eric W. Deutsch; Zhi Sun; Luis Mendoza;
David Shteynberg; Joseph Slagel; Michael Hoopmann;
Terry Farrah; Robert L. Moritz; Institute for Systems Biology,
Seattle, WA

Informatics: Workflow and Data Management, 374 - 386
MP 374

Proteogenomics for the ENCODE Project: Investigating
Genome-Wide Translation; John Wrobel1, 2; Harsha P.
Gunawardena1; Jainab Khatun2; Brian Risk2; Yanbao Yu1;
Morgan C. Giddings2; Xian Chan1; 1University of North
Carolina at Chapel Hill, Chapel Hill, NC; 2Boise State
University, Boise, ID

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Peptide Tracker: A Software Tool for the Management
of Peptides Used in MRM Based Assays; Derek Smith1;
Andrew Chambers1; Andrew Percy1; Dominik Domanski1;
Christoph Borchers1, 2; 1University of Victoria GenomeBC Proteomics Centre, Victoria, BC Canada; 2Dept of
Biochemistry and Microbiology, U Victoria, Victoria, Canada
User Friendly MS Analysis by Taking the Galaxy
Environment to the Cloud; Jorrit Boekel1, 2; Janne
Lehtiö1, 2; Lukas Käll1, 3; 1Science for Life Laboratory, Solna,
Sweden; 2Karolinska Institutet, Stockholm, Sweden; 3KTH
Royal Insitute of Technology, Stockholm, Sweden
Customized Real-Time Control of Benchtop Orbitrap
MS; Andreas Kuehn1; Florian Grosse-Coosmann1; Thomas
Rietpietsch1; Jan-Peter Hauschild1; Katja Tham1; Tim
Stratton2; Derek Bailey1; Robert Malek1; Markus Kellmann1;
Christoph Henrich1; Oliver Lange1; Andreas Wieghaus1;
Stevan Horning1; Alexander Makarov1; 1Thermo Fisher
Scientific (Bremen), Bremen, Germany; 2Thermo Fisher
Scientific (San Jose), San Jose, CA
Reproducible Proteomic Workflows Using Extensions
to the Galaxy Framework; James Johnson; John Chilton;
Pratik Jagtap; Ben Lynch; Tim Griffin; University of
Minnesota, Minneapolis, MN
A Novel Two-Pass Feature Extraction Workflow for the
Statistical Profiling of Mass Spectrometric Data; Norton
Kitagawa 1; Abhijit Rane2; Steven M. Fischer1; Joe Roark1;
Maithilee Samant1; Theodore Sana1; 1Agilent Technologies,
Inc., Santa Clara, CA; 2Persistent Systems, Ltd., Pune, India
MassIVE: Mass Spectrometry Interactive Virtual
Environment for Data Sharing in Proteomics; Jeremy
Carver; Ian Kaufman; Claudiu Farcas; Vineet Bafna; Nuno
Bandeira; UCSD, La Jolla, CA
Metabolomics Data Analysis Framework – Database
and Web Portal for Curation and Analysis of MassSpectrometry Based Metabolomics Data; Alexander
Raskind; Anupama Janga; University of Michigan, Ann
Arbor, MI
Sharing Targeted Proteomics Assays Using Skyline
and Panorama; Vagisha Sharma1; Josh Eckels2; Brendan
MacLean1; Shannon A. Joyner3; Jacob D. Jaffe4; Michael J.
MacCoss1; 1University of Washington, Seattle, WA; 2LabKey
Corp., Seattle, WA; 3Carnegie Mellon University, Pittsburgh,
PA; 4The Broad Institute, Cambridge, MA
ProteomicsDB: A Protein Centric Database and
Repository for LC-MS/MS Data Sets; Mathias Wilhelm1;
Judith Schlegl2; Amin Moghaddas Gholami1; Hannes
Hahne1; Joos-Hendrik Boese2; Marcus Lieberenz2; Mikhail
Savitski3; Yuval Morad2; Lars Butzmann2; Emanuel Ziegler2;
Anton Niadzelka2; Eyk Kny2; Helmut Cossmann2; Siegfried
Gessulat2; Marcus Bantscheff3; Anja Gerstmair2; Franz
Faerber2; Bernhard Kuster1; 1Technical University Munich,
Freising, Germany; 2SAP AG Germany, Walldorf, Germany;
3
Cellzome, Heidelberg, Germany
A Common Analysis Pipeline for Interpretation of
Data from the Clinical Proteomics Tumor Analysis
Consortium (CPTAC); Paul Rudnick1; Niksa Blonder1;
Nathan Edwards2; Yuri Mirokhin1; Dmitrii Tchekovskoi1;
Xinjin Yan1; Stephen Stein1; 1NIST, Gaithersburg, MD;
2
Georgetown University, Washington, DC
Solving the Bioinformatics Bottlenecks of Massive
Storage & Data Distribution, Huge Computational
Needs, and Flexible and Fast Reporting; Gautam Saxena
1
; Christine Jellinek3; Vidya Venkat3; Rafael Dugarte1; Scott
Kuzdzal2; Jennifer Van Eyk3; 1Integrated Analysis, Bethesda,
MD; 2Shimadzu Scientific, Columbia, MD; 3Johns Hopkins
Medical School, Baltimore, MD

MP 386

A Workflow for Novel Image-Based Differential Analysis
of LC/MS Experiments; Hanqing Liao1; Emmanouil
Moschidis1; Isabel Riba-Garcia1; Richard Unwin1; Warwick
Dunn2; Jeffrey Morris3; Jim Graham1; Andrew Dowsey1;
1
University of Manchester, Manchester, UK; 2University of
Birmingham, Birmingham, UK; 3UT MD Anderson Cancer
Center, Houston, TX

Informatics: Crosslinking and Structure Analysis, 387 - 392
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Analyses of Yeast mRNPs by the Use of the PhotoReactive Nucleobase 4-thio-uracil and Mass
Spectrometry; Uzma Zaman1; Kum-Loong Boon1;
Katharina Kramer1; Timo Sachsenberg2; Oliver Kohlbacher2;
Reinhard Lührmann1; Henning Urlaub1; 1Max Planck
Institute for Biophysical chemistry, Goettingen, Germany;
2
University of Tuebingen, Tuebingen, Germany
Development of a Bioinformatics Toolbox to Support
Protein Cross-Linking Mass Spectrometry Analyses;
Mathieu Courcelles; Mike Tyers; IRIC/Université de
Montréal, Montréal, Canada
IMS, HCD, and ETD for Improved Chemical Crosslinking Mass Spectrometry; Eric Merkley1; Erin Baker1;
Kevin Crowell1; Daniel Orton1; Thomas Taverner2; Charles
Ansong1; Yehia Ibrahim1; Meagan Burnet1; John Cort1;
Gordon Anderson1; Richard Smith1; Arnab Mukherjee3; Kyle
Miner3; Ambika Bhagi3; Yi Lu3; Joshua Adkins1; 1Pacific
Northwest National Laboratory, Richland, WA; 2Mango
Solutions, Chippenham, UK; 3University of Illinois UrbanaChampaign, Urbana, IL
ICC-CLASS Software for Automated Data Analysis of
LC-MS MS/MS Crosslinking Data; Evgeniy Petrotchenko1;
Christoph Borchers1, 2; 1University of Victoria-Genome BC
Proteomics Centre, Victoria, Canada; 2Dept of Biochemistry
and Microbiology, U Victoria, Victoria, Canada
MS-based Characterization of Endogenous
Protein Complexes and Interactomes Using Global
Glutaraldehyde Stabilization in the Cellular Milieu;
Roman Subbotin; Júlio Padovan; Brian Chait; The
Rockefeller University, New York, NY
Tissue Transglutaminase is a Negative Regulator of
Monomeric Lactritin Bioactivity and Lacritin Crosslink
Sites Identification by Mass Spectrometry; Kari Green1;
Liwen Zhang1; Gordon Laurie2; 1The Ohio State Universtiy,
Columbus, OH; 2University of Virginia, Charlottesville, VA
Crosslinking, 393 - 412

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The Effect of Chemical Cross-Linking on Protein
Structure and Function; Daniel Rozbesky1, 2; Josef
Chmelik1; Zdenek Kukacka1, 2; Petr Man1, 2; Petr Novak1, 2;
1
Institute of Microbiology, Prague, Czech Republic; 2Charles
University, Prague, Czech Republic
Structure Characterization: Chemical Cross-Linking
Combined with Mass Spectrometry, Dealing with
Impure Protein Sample; Li Peng1; Morten Rasmussen1;
Gunnar Houen2; Peter Højrup1; 1The University of Southen
Denmark, Odense, Denmark; 2Statens Serum Institut,
Copenhagen, Denmark
Charge State Profiles and CID versus ETD
Fragmentation Features of Lys-Lys Cross-Linked
Peptides Using Diimidoester-Based Cross-Linkers;
Hector Koolen; Alexandre Gomes; Fabio Gozzo; UNICAMP,
Campinas, Brazil
Expanding the Nuclease Toolkit for Middle-Down
Characterization of Chemically Modified or Crosslinked
RNA; Matteo Scalabrin; Papa Nii Asare-Okai; Sugyan

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Dixit; John Mangrum; Will McIntyre; Rebecca Rose; Maria
Basanta Sanchez; Daniele Fabris; University at Albany, The
RNA Institute, Albany, NY
A Novel Protein Cross-linker for Mass Spec Analysis:
>95% Enrichment of Cross-linked Peptides in a
“Minimalist Style”; Dan Tan1; Qiang Li1; Xiangke Li1;
Sheng-Bo Fan2; Kun Zhang2; Hao Chi2; Li Tao1; Bing Yang1;
Yue-He Ding1; Pan Zhang1; Xiaohui Liu3; Si-Min He2; MengQiu Dong1; Xiaoguang Lei1, 3; 1National Institute of Biological
Sciences, Beijing, China; 2ICT, Chinese Academy of
Sciences, Beijing, China; 3Tianjin University, Tianjin, China
Extending the Cross-Linking/MS Strategy: Investigation
of Nidogen-1 Complexes by Incorporated PhotoAmino Acids and Photo-Cross-Linking; Philip Lössl1;
Knut Kölbel1; Dirk Tänzler1; Christian Ihling1; Manuel
Keller2; Frank Zaucke2; Jens Meiler3; Andrea Sinz1; 1Martin
Luther University Halle, Halle, Germany; 2Medical Faculty,
University of Cologne, Cologne, Germany; 3Vanderbilt
University, Nashville, TN
Integrative Approach (Chemical Cross-linking and
Hydrogen Deuterium Exchange) Reveals Differences
between Crystal and Solution Structure of FimX-PilZ
Complex; Mariana Fioramonte1; Cristiane R. Guzzo2;
Shaker Chuck Farah2; Fabio C. Gozzo1; 1University of
Campinas, Campinas, Brazil; 2University of São Paulo, São
Paulo, Brazil
Impact of Crosslinker Chemistry on Peptide
Fragmentation Spectra of Crosslinked Peptides; Randy
J. Arnold; Suraj Saraswat; Chao Ji; Haixu Tang; Predrag
Radivojac; James P. Reilly; Indiana University, Bloomington,
IN
Structural Models of Lymphocyte Receptor NKRP1C Revealed by Mass Spectrometry and Molecular
Modeling; Daniel Rozbesky1, 2; Petr Man1, 2; Zdenek
Kukacka1, 2; Zofie Sovova3, 4; Rudiger Ettrich3, 4; Julien
Marcoux5; Carol V. Robinson5; Petr Novak1, 2; 1Institute
of Microbiology, Prague, Czech Republic; 2Faculty of
Sciences, Charles University, Prague, Czech Republic;
3
Institute of Nanobiology and Structural Biology, Nove
Hrady, Czech Republic; 4Faculty of Sciences, University of
South Bohemia, Nove Hrady, Czech Republic; 5Department
of Chemistry, University of Oxford, Oxford, UK
Gas-Phase Intra- and Inter-Molecular Cross-Linking of
Protein and Protein Complexes via Ion/Ion Reactions;
Ian Webb; Yang Gao; Scott McLuckey; Purdue University,
Lafayette, IN
Negative Ion Chemical Cross-linking Coupled With Ion
Mobility Mass Spectrometry for Improved Structural
Analysis of Protein Assemblies; Antonio Calabrese;
Deanna Carmen; Denise Tran; Danielle Williams; Yanqin
Liu; Tara Pukala; University of Adelaide, Adelaide, Australia
Development of Stable Isotope-Labeled CID-cleavable
Cross-linkers for Structural Characterization of Protein
Complexes; Clinton Yu; Wynne Kandur; Athit Kao; Scott
Rychnovsky; Lan Huang; University of California, Irvine, CA
Zero-Length Crosslinking of Protein Heterodimers
Using 15N- Metabolically Labeled Monomers; Karl
Makepeace1; Evgeniy Petrotchenko1; James Bardwell2;
Shu Quan2; Christoph Borchers1, 3; 1University of VictoriaGenome BC Proteomics Centre, Victoria, Canada; 2Dept
of Mol., Cell., and Dev. Biology, U Michigan, Ann Arbor, MI;
3
Dept of Biochemistry and Microbiology, U Victoria, Victoria,
Canada
Novel isotopically-Coded Photoreactive
Heterobifunctional Short-Range Crosslinkers for
Studying Protein Structure; Karl Makepeace1; Nicholas
Brodie1; Evgeniy Petrotchenko1; Christoph Borchers1, 2;

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University of Victoria-Genome BC Proteomics Centre,
Victoria, Canada; 2Dept of Biochemistry and Microbiology, U
Victoria, Victoria, Canada
Mapping Cross-Links Introduced by bis(succinimidyl)3-azidomethyl Glutarate in Complex Protein Samples;
Hansuk Buncherd; Behrad Ghavim; Winfried Roseboom;
Leo J. de Koning; Chris G. de Koster; Luitzen de Jong;
University of Amsterdam, Amsterdam, Netherlands
Crosslinking Study of the Malaria Pathogen Surface
Protein Complex Pf12-Pf41; Michelle Tonkin1; Karl
Makepeace2; Jason Serpa2; Evgeniy Petrotchenko2; Martin
Boulanger1; Carol Parker2; Christoph Borchers1, 2; 1Dept
of Biochemistry and Microbiology, U Victoria, Victoria,
Canada; 2University of Victoria-Genome BC Proteomics
Centre, Victoria, Canada
Evaluating the Potential of an MS/MS-Cleavable CrossLinker for 3D-Structure Analysis of Protein Complexes;
Jens Pettelkau1; Romy Fritzsche1; Christian H. Ihling1;
Mathias Müller3; Mathias Schäfer2; Andrea Sinz1; 1MartinLuther-Universität Halle-Wittenberg, Halle, Germany;
2
Universität zu Köln, Köln, Germany; 3ThermoFisher
Scientific, Bremen, Germany
Quantitative Proteomics of the Prokaryotic Immune
Defense System Including the Analysis of proteinRNA Interactions within the CRISPR/Cas System;
Kundan Sharma1; Britta Stoll2; Anita Marchfelder2; Hagen
Richter3; Lennart Randau3; Henning Urlaub1, 4; 1MaxPlanck-Institut für Biophysikalische Chemie, Gottingen,
Germany; 2Universität Ulm, Ulm, Germany; 3Max-PlanckInstitut für terrestrische Mikrobiologi, Marburg, Germany;
4
Universitätsmedizin Göttingen, Göttingen, Germany
Probing the Human 26S Proteasome Structure by In
vivo Cross-linking and Mass Spectrometry; Athit Kao1;
Xiaorong Wang1; Yingying Yang1; Anthony Burke2; Scott
Rychnovsky2; Pierre Baldi3, 4; Lan Huang1; 1Dept. Phys.
& Biophys., University of California, Irvine, CA; 2Dept. of
Chemistry, University of California, Irvine, CA; 3Dept. of
Comp. Sci., University of California, Irvine, CA; 4Inst. for
Genom. and Bioinf., Univ. of California, Irvine, CA
Investigating the Binding Site of the Psb28 Protein in
Cyanobacterial Photosystem II Using Cross-Linking,
GEE Labeling, and LC-MS/MS; Daniel A. Weisz; Hao
Zhang; Haijun Liu; Michael L. Gross; Himadri B. Pakrasi;
Washington University in St. Louis, St. Louis, MO
1

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H/D Exchange: Protein Structure/Function, 413 - 440
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Hydrogen/Deuterium Exchange Mass Spectrometry
Reveals the Binding Interfaces Between Proliferating
Cell Nuclear Antigen (PCNA) and SPIP; Richard
Yu-Cheng Huang 1, 2; Zhuo Li2; Zvi Kelman1, 2; Jeffrey
Hudgens1, 2; 1NIST, Gaithersburg, MD; 2IBBR, Rockville, MD
Structural Changes of HIV-1 Nef upon Lipid Membrane
Association; Gregory Pirrone1; Michael S. Kent2;
Xiaomeng Shi1; John R. Engen1; 1Northeastern University,
Boston, MA; 2Sandia National Laboratories, Albuquerque,
NM
H/DX Mass Spectrometry Studies for the Stability of
WT Apolipoprotein E and its Interaction with Amyloid-β
1-42; Hanliu Wang; Kanchan Garai; Carl Frieden; Michael
Gross; Washington University in St. Louis, St. Louis, MO
Characterize the Local Conformational Effects of
Chemical Degradation in Recombinant rhDNase by
Hydrogen/Deuterium Exchange Mass spectrometry;
Jian Cao; Jin Li; Justin Jeong; Viswanatham Katta; Jennifer
Zhang; Protein Analytical Chemistry, Genentech Inc., South
San Francisco, CA

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MONDAY POSTERS

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Mechanism of Calmodulin-Induced Activation of
Calcineurin Revealed Using Hydrogen/Deuterium
Exchange Mass Spectrometry; Mohammed AlNaqshabandi; David Weis; University of Kansas, Lawrence,
U.S.
Structural Study of Redox Sensitive Protein, Nm23 by
HDX; Jae Jin Lee; Jaeho Jeong; In-Kang song; Jin-Hwan
Cho; Kong-Joo Lee; College of Pharmacy, Ewha Womans
Univ., Seoul, South Korea
HXMS Investigation of Activation Segment Dynamics
in the Tec-family Tyrosine Kinase Btk; Thomas E.
Wales1; Raji E. Joseph2; Amy H. Andreotti2; John R.
Engen1; 1Northeastern University, Boston, MA; 2Iowa State
University, Ames, IA
Assessment of Protein Structural Differences by
Hydrogen/DeuteriumExchange Mass Spectrometry; Kai
Zhang; Jon Fitchett; Bryan E. Jones; Lilly Biotechnology
Center, San Diego, CA
Locating Zn-bound Histidines in Metalloproteins Using
Hydrogen-Deuterium Exchange Mass Spectrometry;
Jia Dong; Nicholas Borotto; Richard Vachet; University of
Massachusetts Amherst, Amherst, MA
LysRS Novel Function with PhosphorylatedThr52
Revealed by H/D Exchange FT-ICR Mass Spectrometry;
Qian Zhang1; Pengfei Fang2; Min Guo2; Nicolas Young3;
Alan Marshall1, 3; 1Department of Chemistry and
Biochemistry, FSU, TAllahassee, FL; 2The Scripps Research
Institute, Scripps Florida, Jupiter, FL; 3Ion Cyclotron
Resonance Program, NHMFL, TAllahassee, FL
Single Residue Level Hydrogen/Deuterium Exchange
Kinetics Studied by Top-Down Mass Spectrometry
to Probe Protein Solution Structure; Yining Huang;
Don Rempel; Weidong Cui; Michael Gross; Washington
University, St. Louis, MO
Higher-Order Structural Characterization of PostTranslationally Modified Proteins by Top-Down HDXMS with Electron Capture Dissociation; Jingxi Pan1;
Christoph Borchers1, 2; 1University of Victoria-Genome BC
Proteomics Centre, Victoria, Canada; 2Dept of Biochemistry
and Microbiology, U Victoria, Victoria, Canada
Structural Analysis of human RXR Homotetramer
by use of Hydrogen Deuterium Mass Spectrometry;
Jennifer Cushing; Emily Cowart; LeeAnn Boerma; Gang
Xia; Donald D. Muccio; Matthew B. Renfrow; University of
Alabama at Birmingham, Birmingham, AL
Analysis of Huntington’s Disease Related Protein
Aggregates by HDX-ETD-MS; James Arndt; Justin
Legleiter; Kathleen Burke; Stephen Valentine; West Virginia
University, Morgantown, WV
H/DX and Mass Spectrometry Reveal the pH
Dependence Conformational Changes of Diphtheria
Toxin T Domain; Jing Li1; Mykola Rodnin2; Alexey
Ladokhin2; Michael Gross1; 1Washington University in St.
Louis, St. Louis, MO; 2University of Kansas Medical Center,
Kansas city, KS
Exploring the Effects of ATP Binding on the ε Subunit
of Bacterial F0F1-ATPase Using Hydrogen-Deuterium
Exchange Mass Spectrometry; Antony D. Rodriguez;
Stanley D. Dunn; Lars Konermann; The University of
Western Ontario, London, Canada
Antibody-Antigen Interactions Investigated by
Hydrogen/Deuterium exchange Mass Spectrometry;
Başak Kϋkrer; Cristina Puchades Garcia; Otto Diefenbach;
Eveline Sneekes-Vriese; Adrian Apetri; Crucell Vaccine
Institute, Leiden, Netherlands

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Hydrogen/Deuterium Exchange Coupled with Mass
Spectrometry to Measure the Affect of Transition Metals
on β-2 Microglobulin; Nicholas Borotto; Jia Dong; Richard
W. Vachet; University of Massachusetts, Amherst, MA
Microfluidic H/DX MS Analysis of Recombinant
Glycoproteins; Gregory O. Staples 1; Craig D. Wenger1;
Reid A. Brennen1; Yunan Miao3; Terry D. Lee3; Debbie
Ritchey1; Arpad Horvath1; Hongfeng Yin1; Kevin Killeen1;
Julie Cichelli2; 1Agilent Laboratories, Santa Clara, CA;
2
Agilent Technologies, Little Falls, DE; 3City of Hope,
Duarte, CA
Probing Human FXR LBD – Prenylflavonoid Interactions
by Hydrogen/Deuterium Exchange Mass Spectrometry;
Liping Yang; David Broderick; Yuan Jiang; Yan Campbell;
Adrian Gombart; Jan Stevens; Victor Hsu; Claudia Maier;
Oregon State University, Corvallis, OR
NEDD8ylation Induced Conformational Changes in
Cullin Scaffold Protein Studied by Hydrogen Deuterium
Exchange Mass Spectrometry; Sasidhar N Nirudodhi1;
Yuan Jiang3; Haibin Mao2; Ning Zheng2; Claudia S. Maier1;
1
Dept. of Chemistry, Oregon State University, Corvallis, OR;
2
Dept. of Pharmacology, University of Washington, Seattle,
WA; 3Dept. of Statistics, Oregon State University, Corvallis,
OR
Investigating Catalysis-Linked Dynamics in Yeast
Alcohol Dehydrogenase by Measuring Kinetic
Isotope Effects Using Time-Resolved ESI-MS with H/D
Exchange; Peter Liuni; Derek Wilson; York University
Department of Chemistry, Toronto, Canada
Studies of Changes in STAT3 Dynamics upon
Interaction with Novel Small Molecule Dimerization
Inhibitors by TRESI-MS/HDX; Diana Resetca; Derek
Wilson; York University, Toronto, Canada
Hydrogen/Deuterium Exchange Reveals the
Conformational Changes of Human α1-Acid
Glycoprotein upon Glycosylation; Richard Yu-Cheng
Huang 1, 2; Jeffrey Hudgens1, 2; 1NIST, Gaithersburg, MD;
2
IBBR, Rockville, MD
Probing Protein Conformation of Cellobiose
Dehydrogenase by Hydrogen/Deuterium Exchange
Mass Spectrometry; Petr Halada1; Alan Kadek1, 2; Petr
Novak1, 2; Roland Ludwig3; Petr Man1, 2; 1Institute of
Microbiology of ASCR, v.v.i., Prague, Czech Republic;
2
Department of Biochemistry, Charles University, Prague,
Czech Republic; 3Food Biotechnology Laboratory, BOKU
University, Vienna, Austria
Probing Conformational Changes in Amyloid Beta
Aggregation by Pulsed Hydrogen/Deuterium Exchange
Mass Spectrometry; Ying Zhang1; Don Rempel1; Jun
Zhang2; Anuj Sharma1; Liviu Mirica1; Michael Gross1;
1
Washington University in St. Louis, St. Louis, MO;
2
Department of Drug Product Development, Amgen Inc.,
Seattle, WA
Study of Protein Folding/Unfolding Structure
Mechanism of Staphylococcal Nuclease Wild Type
and Its Mutant V66W by PEPS-HDX-ESI-MS; Rohana
Liyanage; Derek Derek Pyland; Jennifer Gidden; Wesely
Stites; Jackson Jackson O. Lay Jr; University of Arkansas,
Fayetteville, AR
Probing Conformational Dynamics of Estrogen
Receptor α (ERα) Co-Activator PGC-1 by H/D Exchange
Coupled with FT-ICR MS; Yeqing Tao1; Sepideh
Khorasanizadeh2; Qian Zhang1; Nicolas Young3; Fraydoon
Rastinejad2; Alan Marshall1, 3; 1Florida State University,
Tallahassee, FL; 2Sanford Burnham Medical Research
Institute, Orlando, FL; 3National High Magnetic Field
Laboratory, Tallahassee, FL

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Proteins: General, 441 - 462
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Characterization of Novel Polyketide Synthase Activity
by the Measurement of Intact Protein and Proteolytic
Products at Amino Acid Level Resolution; Michaela M.
Hinks; Shan M. Randall; Irina Koryakina; Gavin J. Williams;
David C. Muddiman; North Carolina State University,
Raleigh, NC
Limited Proteolytic Cleavage - Mass Spectrometry
Driven Epitope Mapping of IL13ra2; Maria Christina
Malinao; Rebecca Carroll; Claudia Guevara; James Song;
David Tae; Vladimir Kery; Agensys, Inc., Santa Monica, CA
Epitope Structure and Binding Affinity of Single
Chain Llama anti-β-amyloid Antibodies Revealed by
Proteolytic Excision Affinity-Mass Spectrometry;
Paraschiv Gabriela Ioana1; Cecile Vincke2; Paulina
Czaplewska3; Marilena Manea1; Serge Muyldermans2;
Michael Przybylski1; 1University of Konstanz, Konstanz,
Germany; 2Vrije Universiteit Brussel, Brussel, Belgium;
3
University of Gdańsk, Gdańsk, Poland
M+320 Da Ions in the Electrospray Ionization (ESI) Mass
Spectra Of Proteins: Double Glycation or Something
Completely Different? Georg Drabner; Isabel Hermann;
Verena Niggeloh; Roche Diagnostics GmbH, Penzberg,
Germany
Mapping the Binding Sites of New Photoactivatable
Anticancer Complexes to Proteins via FT-ICR MS;
Christopher Wootton; Ilaria Finazzi; Mark Barrow; Peter B.
O’Connor; Peter J. Sadler; University of Warwick, Coventry,
UK
Proteomic Identification of the BACE1 Cleavage Sites;
Nicole Heinks; Erik Carlson; Joseph Johnson; University of
Minnesota, Duluth, Duluth, MN
Protein Quantitation in Industrial Fermentation; Barbara
S. Larsen; Timothy Snow; Andrew Eliot; The DuPont
Company, Wilmington, DE
Degradation Processes of Archaeological Silk Proteins
to Remind in Mass Spectrometry; Kazuki Kawahara1;
Mayumi Yamada2; Fumio Okada3; Miho Muguruma1;
Atsuko Miyaji1; Yoshiki Matsuo1; Takashi Nakazawa1; 1Nara
Women’s University, Nara, Japan; 2Biosys Technologies,
Inc., Tokyo, Japan; 3Kyoto University of Art and Design,
Kyoto, Japan
Stress Response in Daphnia pulex; Aaron Steevensz1;
Roland Vergilino1; Melania Cristescu2; Panayiotis Vacratsis1;
1
University of Windsor, Windsor, Canada; 2McGill University,
Montreal, Canada
Intact Protein Supercharging and Characterization; Ravi
Kumar Krovvidi1; Arunkumar Padmanaban1; Vadiraja Bhat2;
1
Agilent Tech, Bangalore, India; 2Agilent, LittleFalls
Rapid Mass Spectrometric Analysis of DisulfideContaining Proteins Following Online Digestion, Online
Electrolytic Reduction and DESI Analysis; Qiuling
Zheng1; Hao Zhang2; Hao Chen1; 1Ohio University, Athens,
OH; 2Washington University, St. Louis, MO
Investigating Redox Regulation in the Apoptotic
Pathway using High Resolution Mass Spectrometry;
Sophie Thurlow1; David Clarke1; Jenna Scotcher2; Colin
Campbell1; C. Logan Mackay1; Patrick Langridge-Smith1;
1
Edinburgh University, Edinburgh, UK; 2NHMFL, Florida
State University, Tallahassee, FL
Characterization of Redox-Labile Disulfide Bonds in
Protein Using Differential Alkylation with O16/O18
Labeled Iodoacetic Acid; Shunhai Wang; Igor Kaltashov;
University of Massachusetts, Amherst, MA

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Online Electrochemical Reduction of the Disulfide
Bond(s) in Oxytocin and Hepcidin Results in Different
CID and ETD Fragmentation Spectra; Martin A. Giera1;
Simone Nicolardi1; Pieter Kooijman1; Agnieszka Kraj2;
Jean-Pierre Chervet2; André M. Deelder1; Yuri E.M. van
der Burgt1; 1Leiden University Medical Center, Leiden,
Netherlands; 2Antec, Zoeterwoude, Netherlands
An Enrichment Approach Using a Highly Selective
Aptamer Modified PS-DVB Microbeads for Subpicomole
Level Lysozyme Detection by Mass Spectrometry; Ülkü
Güler; Ömür Çelikbıçak; Bekir Salih; Hacettepe University,
Department of Chemistry, Ankara, Turkey
Identification of Gamma Carboxylation of Human Gas6
by Tandem Mass Spectrometry; Li Zhang1; Kevin Xiao2;
Faye Fang1; 1R&D Systems Inc, Minneapolis, MN; 2Dept of
Medicine, Duke University Medical Center, Durham, NC
Evaluation of Expressed Sequence Tags for the
Identification of Taenia solium Metacestode Excretion/
Secretion Proteins; Bjorn Victor1; Pierre Dorny1; Kirezi
Kanobana1; Katja Polman1; Johan Lindh2, 3; André M.
Deelder4; Magnus Palmblad4; Sarah Gabriël1; 1Institute
of Tropical Medicine, Antwerpen, Belgium; 2Karolinska
Institutet, Stockholm, Sweden; 3Swedish Institute for
Communicable Disease Control, Solna, Sweden; 4Leiden
University Medical Center, Leiden, The Netherlands
Enhancing Peptide Identification by Combining an
Efficient Protein Extraction Procedure with Dynamic
Inclusion/Exclusion Lists in Data-Dependent LC-MS/
MS Acquisition Mode; Ying Zhang1; Dario Bottinelli1; Aivett
Bilbao1, 2; Bandar Alghanem1; Frédéric Nikitin2; Markus
Müller2; Frédérique Lisacek2; Jeremy Luban3; Caterina
Strambio De Castillia3; Emmanuel Varesio1; Gérard
Hopfgartner1; 1University of Geneva, Geneva, Switzerland;
2
Swiss Institute of Bioinformatics, Geneva, Switzerland;
3
University of Massachusetts, Worcester, MA
“MELD”: A Bottom-Up Method to Fully de novo
Sequence Purified Proteins; Gabriel Mazzucchelli1; Tyler
Zimmerman2; Marie-Alice Meuwis1; Nicolas Smargiasso1;
Edwin De Pauw1; 1Univeristy of Liege, MS Lab - GIGA,
Liege, Belgium; 2National Institute of Standards and
Technology, Gaithersburg, MD
Optimization of a Broad Specificity Protease for
Routine Bottom-Up Protein and Post-Translational
Modification Identification; Mike Naldrett; Ellen Marsh;
Sophie Alvarez; Donald Danforth Plant Science Center, St
Louis, MO
Extent of Urea-Induced Protein Carbamylation during
Sample Preparation; Laxmikanth Kollipara; René Zahedi;
Leibniz-Institut für Analytische Wissenschaften, Dortmund,
Germany
High-throughput Scheduled MRM for Multiplexed
Quantitation of Chemical Probe Labeled Enzymes
in Human Cells; Song Li1; Pamela Diego1; Santosh
Keshipeddy1; Bekim Bajrami1; Vahid Farrokhi1; Adam
McShane1; Ying Wai Lam2; Bin Deng2; Reza Nemati1; Amy
Howell1; Xudong Yao1; 1University of Connecticut, Storrs,
CT; 2University of Vermont, Burlington, VT

New Advances in Quantitative Proteomics, 463 - 493
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Improving SWATH by Overlapped Windows; David
Cox; Sandra Chu; Stephen Tate; Ron Bonner; AB SCIEX,
Concord, Canada
Improved Peptide Fractionation Efficency in IonMobility Based Data-Indendent Acquisition Enables the
Identification of >4400 Proteins Using an Optimized
1D-nanoUPLC-IMS-MSE Workflow; Ute Distler; Jörg

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Kuharev; Stefan Tenzer; UMC of the Johannes Gutenberg
University Mainz, Mainz, Germany
The Iterative Data Analysis towards the Unfractionated
SWATH Data through Expansion of Ion Library; Shenyan
Zhang1, 2; Bo Wen1; Shaohang Xu1; Baojin Zhou1; Zhen
Chen2; Quanhui Wang1, 2; Xiaomin Lou2; Haidan Sun2; Liang
Lin1; Siqi Liu1, 2; 1BGI-Shenzhen, Shenzhen, China; 2Beijing
Institute of Genomics, CAS, Beijing, China
Exploring Transition from SWATH Acquisition to MRM
Analysis for Quantitative Proteomics; Sahana Mollah;
Christie Hunter; AB SCIEX, Foster City, CA
Using Fractionation and Labeling with Data
Independent Acquisition; Sean L. Seymour; Christie L.
Hunter; AB SCIEX, Foster City, CA
Can We Use Conserved Domains to Reveal Unique
Protein Functions Present in Hydrothermal Vent Plume
Microbial Communities? Brook Nunn1; Timothy Mattes2;
Sonia Ting1; Giora Proskurowski1; Michael MacCoss1;
Deborah Kelley1; David Goodlett3; Robert Morris1;
1
University of Washington, Seattle, WA; 2University of Iowa,
Iowa City, IA; 3University of Maryland, Baltimore, MD
Developing Peptide Library for SWATH™ Based
Proteomic Profiling; Melinda Wojtkiewicz; Jessica Winkler;
Jayme Wiederin; Lance Villeneuve; Kelly Stauch; Howard
S. Fox; Pawel Ciborowski; University of Nebraska Medical
Center, Omaha, NE
Understanding the Role of Proteolytic Digestion on
Discovery – and Targeted-Proteome Measurements
Using LC-MS/MS; Philip Loziuk; North Carolina State
University, Raleigh, NC
Combining Pulsed-SILAC Labeling and ClickChemistry to Probe Rapid Proteome and Secretome
Dynamics – Application to Macrophage Activation;
Katrin Eichelbaum; Jeroen Krijgsveld; EMBL Heidelberg,
Heidelberg, Germany
Quantitative Degradomics Using an Isotope Labeled
Mass Tag; Kazutaka Shimbo1, 2; Sami Mahrus2; Robert
Chalkley2; James Wells2; 1Ajinomoto CO., INC, KawasakiShi, Japan; 2University of California, San Francisco, CA
Proteomic Analysis Identifies Differentially Expressed
Proteins after Red Propolis Extract Treatment in Hep2 Cells; Mariana Roesch-Ely1; Sidnei Moura1; Caroline
Olivieri da Silva Frozza1; Tanara da Silva Ribeiro1; Paulo
Marcos Pinto2; Francine Ferreira Padilha3; João Antonio
Pêgas Henriques1; 1University of Caxias do Sul, Caxias
do Sul, Brazil; 2Federal University of Pampa, São Gabriel,
Brazil; 3Tiradentes University, Aracaju, Brazil
Quantitative Analysis of the C2C12 and Mouse Skeletal
Muscle Proteomes Using a Multiplexing Strategy;
Michelle Henderson; John Chilton; Getiria Onsongo; Pratik
Jagtap; Edgar Arriaga; U of M, Minneapolis, MN
Coping with the Trade-Off between Comprehensive
Identification and Accurate Quantitation Using Stable
Isotope Dimethyl Labeling; Masaki Wakabayashi; Naoyuki
Sugiyama; Yasushi Ishihama; Kyoto University, Kyoto,
Japan
High Throughput Quantitative p-SILAC in Niche
Model Organisms; Mario Looso1; Christian Michel1; Marc
Bruckskotten1; Jens Preussner1; Panagiotis Tsonis2; Marcus
Krueger1; Thomas Braun1; 1Max-Planck-Institute for Heart
and Lung Research, Bad Nauheim, Germany; 2TREND,
University of Dayton, Dayton, OH
Depolarization Dependent Spatial Localization of
Proteins in Nerve Terminals; María Ibáñez-Vea; Sanah
Shah; Alistair Edwards; Lene Jakobsen; Martin R. Larsen;
University of Southern Denmark, Odense, Denmark

MP 478

MP 479

MP 480

MP 481

MP 482

MP 483

MP 484

MP 485

MP 486

MP 487

MP 488

MP 489

Identification of Targets of c-Src Tyrosine Kinase by
Chemical Complementation and Phosphoproteomics.
Exploring the Mechanism of Activation of Rap1GEF
(C3G); Isabel Martinez Ferrando1; Raghothama
Chaerkady1; Jun Zhong1; Henrik Molina2; Harrys Jacobs1;
Katie Herbst-Robinson3; Beverley Dancy1; Vikram Katju4;
Ron Bose5; Jin Zhang1; Akhilesh Pandey1; Cole Philip1;
1
Johns Hopkins School of Medicine, Baltimore, MD;
2
Rockefeller University, New York City, US; 3University of
Pennsylvania, Philadelphia, US; 4M.D. Anderson Cancer
Center. University of Texas, Houston, US; 5Washington
University School of Medicine, Saint Louis, US
Quantitative Proteomic and Proteogenomic Comparison
of hESC and Neurons; Harsha P. Gunawardena 1; John
Wrobel1; Jainab Khatun2; Brian Risk2; Morgan C. Giddings2;
Xian Chen1; 1University of North Carolina at Chapel Hill,
Chapel Hill, NC; 2Boise State University, Boise, ID
Identification and Validation of PRP4 Kinase Substrates
with Integrated Proteomics Approaches; Qiang Gao;
Nayantara Kothari; Zhuyan Guo; Huang Shih-Min A; Hong
Cheng; Bailin Zhang; Sanofi Oncology, Cambridge, MA
Synthesis of d-Labeled and Unlabeled Ethyl Succinic
Anhydride and Application to Quantitative Analysis of
Peptides by Isotope Differential Mass Spectrometry;
Satomi Niwayama; Masoud Zabet-Moghaddam; Aarif
Shaikh; Texas Tech University, Lubbock, TX
Application of CESI-MS on SILAC-based Quantitative
Proteomics; Herbert H. Lindner1; Klaus Faserl1; Leopold
Kremser1; Martin Mueller2; David Teis2; Bettina Sarg1;
1
Biocenter, Division of Clinical Biochemistry, Innsbruck,
Austria; 2Biocenter, Division of Cell Biology, Innsbruck,
Austria
In-Source Fragmentation and the Sources of Partially
Tryptic Peptides in Shotgun Proteomics; Jong-Seo
Kim1, 2; Matthew E. Monroe1; David G. Camp II1; Richard
D. Smith1; Wei-Jun Qian1; 1Pacific Northwest National Lab,
Richland, WA; 2Institute for Basic Science, Seoul National
Univ., Seoul, Korea
Faster Protein Identification with Surface Acoustic
Wave Nebulization in Place of Infusion-based ESI; Sung
Hwan Yoon1, 2; Young Ah Goo1, 2; Michael Wilson1, 2; Yue
Huang1; J. Scott Edgar3; Scott Heron1, 2; David R. Goodlett1,
2 1
; University of Washington, Seattle, WA; 2University of
Maryland, Baltimore, MD; 3Deurion LLC, Seattle, WA
193 nm Ultraviolent Photodissociation for High
Throughput Middle-Down Proteomics; Joe R. Cannon;
Jennifer S. Brodbelt; Univ. of Texas at Austin, Austin, TX
Increased Peptide and Protein Identification Rate for
Proteomics Samples by Controlling Peptide Charge
States Generated by Captive Spray; Stephanie Kaspar;
Stuart Pengelley; Thorsten Ledertheil; Ralf Hartmer;
Wolfgang Jabs; Carsten Baessmann; Bruker Daltonik,
Bremen, Germany
Characterization and Optimization of a High Field
Orbitrap for Proteome Analysis; Fiona Pachl; Bernhard
Kuster; Technical Universitiy Munich, Freising, Germany
Deep Proteome Mapping of HeLa and U2OS Human
Cancer Cell Lines; Cristian Ruse1; Samantha Peacock1;
Vadiraja B Bhat 2; 1Cold Spring Harbor Laboratory, Cold
Spring Harbor, NY; 2Agilent Technologies, Wilmington, DE
Travelling Wave Ion Mobility Assisted Duty Cycle
Enhancements for Targeted and Non-Targeted
Proteomics Experiments; Christopher J Hughes;
Johannes PC Vissers; James Langridge; Waters,
Manchester, UK

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GENERAL
INFORMATION

MP 490

MP 491

MP 492

MP 493

Large Scale Targeted Protein Quantification Using HR/
AM Selected Ion Monitoring with MS/MS Confirmation
on A Novel Hybrid, Q-OT-qIT Mass Spectrometer;
Reiko Kiyonami1; Michael Senko1; Vlad Zabrouskov1;
Jarrett Egertson2; Sonia Ting2; Michael MacCoss2; Andreas
Hühmer1; 1ThermoFisher Scientific, San Jose, CA;
2
University of Washington, Seattle, WA
Characterization of Proteomics Performance of a Novel
Collision Cell for Ultrahigh Resolution Time of Flight
Mass Spectrometers (UHR-TOF); Markus Lubeck; Ralf
Hartmer; Oliver Raether; Carsten Baessmann; Bruker
Daltonik GmbH, Bremen, Germany
Protein Separation and Identification Using Capillary
Isoelectric Focusing (clEF) Coupled to Mass
Spectrometry; Sunil Adav; Siu-Kwan Sze; Nanyang
Technological University, Singapore, SG
Reproducibility of SWATH™ MS Analysis and
Implications for System Biology Studies; Yang Kang;
Stephen Tate; Christie Hunter; Suya Liu; Ron Bonner; AB
Sciex, Concord, Canada

MP 502

MP 503

MP 504

Protein Therapeutics: Quantitative Analysis, 494 - 521
MP 494

MP 495

MP 496

MP 497

MP 498

MP 499

MP 500

MP 501

Intact 20kDa Extracellular Domain of APO2L/TRAIL
Bioanalysis by HRMS: A Potential Cancer Therapeutic
Protein; Jean-Nicholas Mess; Fabio Garofolo; Algorithme
Pharma Inc., Laval, Quebec, Canada
Iodine-129 Microdosing for Protein and Peptide Drug
Development; Robert-Jan Lamers1; José Maria LópezGutiérrez2; Jose Manuel Gómez-Guzmán2; Peter Boshuis3;
1
Abundnz B.V., Woerden, The Netherlands; 2Universidad
de Sevilla, CNA, Sevilla, Spain; 3Ducares, Utrecht, The
Netherlands
Quantitative Analysis of Blood Coagulation Factor VIII
Therapeutics in Plasma Using UPLC/MS; Hiroya Miura1;
Taiji Kawase2; Kenji Hirose2; 1Japanese Blood Products
Organization, Tokyo, Japan; 2Nihon Waters K.K., Tokyo,
Japan
Mass Spectrometry-Based Protein Quantification for
Improved Definition of Therapeutic Targets; Juergen
Kast 1; Martin Barnes1; Robert Boyd1; Jason Allen1; Amanda
Anderson1; Jim Ackroyd1; Ludmila Bozhenok1; Lindsey
Hudson1; Xiaohong Yu1; Jonathan Terrett2; Christian Rohlff1;
1
Oxford BioTherapeutics Ltd, Milton Park, Abingdon, UK;
2
Oxford BioTherapeutics Inc, San Jose, CA
NTCB Cleavage of Proteins: First Application for
Protein Therapeutics Quantitative Analysis in Mass
Spectrometry; Barbara Marsiglia; Luca Genovesi; Marina
Feroggio; Luca Barbero; Merck Serono, Colleretto Giacosa,
Italy
On the Feasibility of Using Non-Ferrous Metals as
Tracers of Transferrin-Based Therapeutics in Clinical
Samples; Hanwei Zhao; Shunhai Wang; Cedric E. Bobst;
Igor A. Kaltashov; University of Massachusetts, Amherst,
MA
Development of a Quantitative Mass Spectrometric
Method to Measure the Protein Components in Virus
Like Particles Used for Vaccination; Michael D. Ward1;
Ernst E. Brueggemann1; Lisa H. Cazares2; Sina Bavari1;
1
USAMRIID, Ft. Detrick, MD; 2Geneva Foundation/
USAMRIID, Frederick, MD
Development and Application of a Comprehensive
Isotope-labeled Peptide Library to Quantify the Twelve
Signal Transduction Pathways of Carcinogenesis;
Lisa A Vasicek1; Kelly A. Conrads1; Yutaka Shoji2; Brian
L. Hood1; Amol Prakash3; Scott Peterman3; Joel Louette3;
Chad A. Hamilton1, 4; G. Larry Maxwell1, 5; John I. Risinger2;

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MP 505

MP 506

MP 507

MP 508

MP 509

MP 510

MP 511

MP 512

MP 513

Thomas P. Conrads1; 1Women’s Integrated Research
Center at Inova Health, Annandale, VA; 2Michigan State
University, Grand Rapids, MI; 3ThermoFisher Scientific, Inc.,
BRIMS, Cambridge, MA; 4Walter Reed National Military
Medical Center, Bethesda, MD; 5INOVA Fairfax Hospital,
Falls Church, VA
Identification and Quantification of Low Abundant
Proteins in Biotherapeutics by a Sensitive and
Universal LC-High Resolution MS Based Assay;
Hongxia (Jessica) Wang; Zhiqi Hao; Yi Zhang; David Horn;
Patrick Bennett; Thermo Fisher Scientific, San Jose, CA
Integrated Targeted Quantitation Method for Insulin
and Its Therapeutic Analogs; Eric E. Niederkofler1; Tara
Schroeder2; Dobrin Nedelkov1; Urban A. Kiernan1; David
A. Phillips1; Kemmons A. Tubbs1; Scott Peterman3; Bryan
Krastins3; Amol Prakash3; Mary Lopez3; 1Tempe Thermo
Fisher Scientific, Tempe, AZ; 2Thermo Fisher Scientific,
Somerset, NJ; 3BRIMS Thermo Fisher Scientific, Boston,
MA
Quantitation of a Therapeutic Protein in Rat Plasma by
a Validated UPLC/MS/MS and Its Application to a GLP
Toxicokinetic Study; Bailuo Ren; Yan Mao; David Roos;
John Yu; Jeffrey Duggan; Boehringer Ingelheim Pharma,
Ridgefield, CT
Development and Validation of an Assay for
Quantitation of a Therapeutic Protein in Human Urine
Using an LC/MS/MS Method; David Roos; John Yu;
Jeffrey Duggan; Lin-Zhi Chen; Elsy Philip; Boehringer
Ingelheim, Ridgefield, CT
LC/MS/MS Assays for Biotherapeutic Protein
Quantitation in Biological Matrixes – Regulatory
Considerations, Validation Procedures and Results;
David Roos; John Yu; Jeffrey Duggan; Lin-Zhi Chen; Shirin
Pagels; Boehringer Ingelheim, Ridgefield, CT
Quantification of Human mAbs in Mouse Tissues
Using Generic Immunocapture and LC-MS/MS; Bogdan
Sleczka1; John T. Mehl1; Katherine Lewis2; Robin Moore1;
Ragini Vuppugalla1; Celia D’Arienzo1; Tim Olah1; 1BristolMyers Squibb, Princeton, NJ; 2Bristol-Myers Squibb
(Zymogenetics), Seattle, WA
SPE Cleanup of Background Peptides for the LC-MS/
MS Bioanalysis of a Monoclonal Antibody in Monkey
Serum; Long Yuan; Qin Ji; Anne-Françoise Aubry; BristolMyers Squibb, Princeton, NJ
High-sensitivity Quantitative Analysis of Therapeutic
Monoclonal Antibodies in Human Serum Using
Q Exactive Selected Ion Monitoring NanoLC-MS;
Haibo Qiu1; Hongxia Wang2; Patrick Bennett2; Ning Li1;
1
Regeneron Pharmaceuticals, Tarrytown, NY; 2Thermo
Fisher Scientific, San Jose, CA
Strategies for Calibration and Signature Peptide
Selection are Critical for Accurate Absolute
Quantification of Therapeutic Monoclonal Antibodies
in Pharmaceutical Matrices; Ming Zhang; Haoying Yu;
Eslam Nouri-Nigjeh; Jun Qu; University at Buffalo, Buffalo,
NY
Comparison of Methods for Quantitating Tryptic
Digests of Monoclonal Antibodies using Q-TOF and
QQQ Mass Spectrometry; Caroline S. Chu; Alex Zhu;
Ning Tang; Agilent Technologies, Santa Clara, CA
Determination of Contaminant Bacterial Host Cell
Proteins in Recombinant Proteins Expressed in E. coli
by LC-QQQ; Oscar Potter; Yanan Yang; Hongfeng Yin;
Kevin Killeen; Agilent Technologies, Santa Clara, CA
Quantification of Large Peptides in Human Serum
Using High Resolution Dual Ion Funnel LC-QTOF; Anne
E Blackwel; Rory Doyle; Alex Zhu; Vadiraja B. Bhat; Agilent

61ST ASMS CONFERENCE ON MASS SPECTROMETRY

MONDAY POSTERS

MP 514

MP 515

MP 516

MP 517

MP 518

MP 519

MP 520

MP 521

Technologies, Wilmington, DE
Quantitative Analysis of a Therapeutic Monoclonal
Antibody in Human Plasma by Accelerated Trypsin
Digestion and LC-MS/MS; Jianshuang Wang; Fumin Li;
Douglas Fast; Covance, Madison, WI
Low ng/ml Bioanalysis of Monoclonal Antibody
Therapeutics Using nano-UPLC Coupled to HRMS;
William Douglas Van Dongen; Frédérique Van Holthoon;
Richard Bas; Anne Kleinnijenhuis; TNO Triskelion, Zeist,
Netherlands
Simultaneous Quantitative Peptide Mapping and Host
Cell Protein Detection in an IgG1 Monoclonal Antibody
Preparation using Data-Independent Acquisition; Eric
Johansen; Kelli Jonakin; Christie Hunter; AB SCIEX, Foster
City, CA
Accurate Quantitation of Deamidated Peptides by
Spectral Accuracy; Darryl Davis1; Ming Gu2; 1Johnson and
Johnson, Radnor, PA; 2Cerno Bioscience, Norwalk, CT
Simultaneous Quantitation of a Monoclonal Antibody
and Two Proteins in Human Plasma by High Resolution
and Accurate Mass Measurements; Paul-Gerhard
Lassahn1; Kai Scheffler2; Myriam Demant3; Nathanael
Delmotte1; Winfried Wagner-Redeker1; Guenter Boehm4;
1
Swiss BioAnalytics AG, Basel, CH; 2Thermo Fisher
Scientific, Dreieich, Germany; 3ThermoFisher Scientific,
Reinach, CH; 4CTC Analytics AG, Zwingen, CH
Quantification of Biotherapeutics in DMPK Studies
Using Accurate Mass MS/MS; Joanne Mather1; Robert S.
Plumb2; Gordon Fujimoto1; Jonathan R. Kheller3; Matthew
E. Szapacs3; Christopher Evans3; 1Waters Corporation,
Milford, MA; 2Imperial College, London, UK; 3GSK, King of
Prussia, PA
Development of an Immunoprecipitation and LCMS/MS Based Method for Quantifying the 105 kDa
Recombinant Protein SXN101959 in Plasma; Steve
Pleasance1; Richard Kay1; David Griffiths1; Aimee Cossins2;
Andrew Splevins2; Alberto Martinez2; Helen Ludlow2;
1
Quotient Bioresearch Ltd, Fordham, England; 2Syntaxin
Ltd, Abingdon, England
Improved Identification and Quantitation of Host Cell
Proteins in Protein Therapeutics using 2D-LC and Ion
Mobility; Martha Stapels; Catalin Doneanu; Keith Fadgen;
Waters Corporation, Milford, MA

Biomarker Quantitation: Proteins and Peptides, 522 - 549
MP 522

MP 523

MP 524

MP 525

Targeted Proteomics Workflow for Biomarker Analysis
by Nano LCMS; Jorge Smith1; Jeremy Post1; Rachel
Lieberman1; Nataliya Bulayeva2; Kevin Rosenblatt2; Ben
Figard1; 1Shimadzu Scientific Inst., Houston, TX; 2UT-Health
Science Center at Houston, Houston, TX
Targeted Quantification of Proteins at Sub-nanogram/
mL Levels in Human Plasma by MRM-MS without
the Need for Fractionation; Michael Burgess; Hasmik
Keshishian; D.R. Mani; Michael Gillette; Steven Carr; Broad
Institute, Cambridge, MA
Analysis of Serum Myostatin and Its Inhibitors
N-terminal Pro-protein, GASP-1 and FLRG
Simultaneously in Human Serum by LC-MS/MS;
Patrick Vanderboom; Olga Bondar; Linda Benson; Nathan
LeBrasseur; Sundeep Khosla; Robert Bergen; Mayo Clinic,
Rochester, MN
Immunoaffinity Enrichment and Quantification of Serum
Proteins Using Stable Isotope Labeled Proteins as
Internal Standards; Kevin Ray; Jim J. Walters; Melissa R.
Radabaugh; Sigma-Aldrich, St. Louis, MO

MP 526

MP 527

MP 528

MP 529

MP 530

MP 531

MP 532

MP 533

MP 534

MP 535

MP 536

MP 537

MP 538

Characterization of Heavy Recombinant Proteins
for Use as Internal Standards in Quantitative MS
Workflows; Gordon R. Nicol; Pegah Jalili; Mark Angeles;
David Rhee; Kevin Ray; Sigma, St Louis, MO
MRMcubed (MRM3) Optimization for Direct
Quantification of Low Abundance Protein in Biological
Fluids : Application to Plasma Biomarkers; Jeremy
Jeudy; Arnaud Salvador; Romain Simon; Aurore Jaffuel;
Catherine Fonbonne; Jerome Lemoine; Institut des
Sciences Analytiques, Villeurbanne, France
Development and Validation of a Sensitive LC/MS/MS
Assay for Fibrinogen Peptide A Quantitation in Human
Plasma Using Nano-flow LC with Trizaic Tile; Mingxiang
Lin; Michael Lassman; Russell Weiner; Omar Laterza;
Merck Research Laboratories, Rahway, NJ
Quantification of Fibrin D-dimer by Peptide
Immunoaffinity Enrichment and Tandem Mass
Spectrometry; Weixun Wang1; Bernard Choi1; Nykia
Walker1; Li-ji Zhu1; Weizhen Wu1; Ge Lan1; David E.
Gutstein1; Nathan A. Yates2; Ronald C. Hendrickson3; Martin
L. Ogletree1; Michele Cleary1; Gregory J. Opiteck1; Zhu
Chen1; Lucinda H. Cohen1; 1Merck Research Labs, Rahway,
NJ; 2University of Pittsburgh, Pittsburgh, PA; 3Memorial
Sloan-Kettering Cancer Center, New York, NY
Pyroglutamyl apelin-13 Identified as the Major Apelin
Isoform in Human Plasma; Eugene Y. Zhen; Richard E.
Higgs; Jesus A. Gutierrez; Eli Lilly & Company, Indianapolis,
IN
Ultra-sensitive Immunoaffinity-UPLC/MS/MS
Quantitation of Oxytocin in Rat Plasma; Sarah Osgood;
Angela Doran; Kari Fonseca; Thomas McDonald; Yanhua
Zhang; Hongying Gao; Pfizer, Groton, CT
Ultrasensitive Quantification Assay for Oxytocin in
Human Plasma Using a LC/MS Microfluidic Platform;
Catalin Doneanu; Paul Rainville; Waters Corporation,
Milford, MA
High Sensitivity and Simultaneous Quantitation
Method for Arginine Vasopressin and Desmopressin in
Human Plasma Determined by LC-MS/MS/MS; Yasuko
Tsukazaki1; Naoto Senda1; Shigeru Yamada3; Kinya Kubo2;
Yasuhiro Kazuki2; Mitsuo Oshimura2; 1Mitsubishi Chemical
Medience Co., Tsukuba, Ibaraki, Japan; 2Chromosome
Engineering Research Center, Tottori University, Yonago,
Tottori, Japan; 3K.K.AB SCIEX, Shinagawa, Tokyo, Japan
Surrogate Matrix and Surrogate Analyte Approaches
for the Quantitation Amyloid β Peptide Biomarkers in
Human Cerebrospinal Fluid via LC-MS/MS; William R.
Mylott; Junlong Shao; Moucun Yuan; Bruce Hidy; Rand
Jenkins; PPD, Richmond, VA
Mass Spectrometry Quantification of Amyloid Precursor
Protein Isoforms to Study Alzheimer’s disease by
QconCAT Strategy; Junjun Chen; Illarion V. Turko; IBBR,
Rockville, MD
MRM-based Multiplexed Quantification of Progranulin
and Granulin Peptides in Mouse Serum; Toshiya
Matsubara1, 2; Tairo Ogura1; Ichiro Hirano1; Susumu Seino2;
1
Shimadzu Corporation, Kyoto, Japan; 2Kobe University
Graduate School of Medicine, Kobe, Japan
Development of a Sensitive LC-MS/MS Assay for
Quantitative Analysis of Hepcidin-25 in Human Urine;
Chaoran Ron Huang; Tao Ye; Liyu Yang; Biogen Idec,
Cambridge, MA
Mass Spectrometry-Based Approach for Absolute
Quantitative Characterization and Validation of
Neuronal-Glial Injury Biomarkers in Tissue and
Biofluids; Ahmed Moghieb; Nancy Denslow; Richard Yost;
Kevin Wang; University of Florida, Gainesville, Fl

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POSTERS
GENERAL
INFORMATION

MP 539

MP 540

MP 541

MP 542

MP 543

MP 544

MP 545

MP 546

Quantitative Mass Spectrometry for Proteomic
Screening of Potential Biomarkers in Alzheimer’s
Disease; Sravani Musunuri; Kim Kultima; Martin Ingelsson;
Lars Lannfelt; Jonas Bergquist; Magnus Wetterhall; Ganna
Shevchenko; Uppsala University, Uppsala, Sweden
Targeted Quantification of Low-Abundance
TMPRSS2:ERG Fusion Proteins in Prostate Cancer
Using a Highly Sensitive PRISM-SRM approach; Jintang
He 1; Xuefei Sun1; Tujin Shi1; Athena A. Schepmoes1;
Thomas L. Fillmore1; Vladislav A. Petyuk1; Fang Xie1;
Rui Zhao1; Marina A. Gritsenko1; Feng Yang1; Naoki
Kitabayashi2; Sung-Suk Chae2; Mark A. Rubin2; Javed
Siddiqui2; John T. Wei3; Arul M. Chinnaiyan3; Wei-Jun Qian1;
Richard D. Smith1; Jacob Kagan4; Sudhir Srivastava4;
Tao Liu1; Karin D. Rodland1; David G. Camp, II1; 1Pacific
Northwest National Laboratory, Richland, WA; 2Weill
Cornell Medical College, New York, NY; 3University of
Michigan, Ann Arbor, MI; 4National Cancer Institute,
Rockville, MD
Prioritization of Plasma-Based Predictive Markers for
Chemotherapy in Lung Cancer Using Fractionation
and Targeted Mass Spectrometry; Haizhen Zhang1;
Jeffrey Whiteaker1; Chenwei Lin1; Pin Yan1; Yeoun Jin Kim2;
Helen Ross3; Tony Tegeler4; Cheryl Selinsky4; Konstantinos
Petritis4; Guy Berchem2; Bruno Domon2; Amanda
Paulovich1; 1Fred Hutchinson Cancer Research Center,
Seattle, WA; 2Luxembourg Clinical Proteomics Center,
Luxembourg, Luxembourg; 3Mayo Clinic, Scottsdale, AZ;
4
Translational Genomics Research Institute, Phoenix, AZ
Targeted Quantification of Low-Abundance CancerRelated AGR2 Proteins in Clinical Prostate Cancer
Specimens Using an Antibody-Free PRISM-SRM Assay;
Tujin Shi1; Yuqian Gao1; Dian Su1; Sue-Ing Quek2; Carrie
Nicora1; Thomas L. Fillmore3; Athena A. Schepmoes1; Rui
Zhao3; Ronald J. Moore1; Keqi Tang1; Karin D. Rodland1;
Tao Liu1; Richard D. Smith1; David G. Camp1; Alvin Y.
Liu2; Wei-Jun Qian1; 1PNNL, Richland, WA; 2Department
of Urology, University of Washington, Seattle, WA;
3
Environmental Molecular Sciences Laboratory, PNNL,
Richland, WA
MRM Analysis of Breast Adenocarcinomas Induced
to Epithelial to Mesenchymal Transition; Daniele
Albuquerque1; Camila Palma1; Fernanda Melo2; Mariana
Pinto2; Carolina Thome2; Gabriela Canchaya1; Vera
Epifanio1; Dimas Covas1, 2; Vitor Faça1; 1Fac. Medicina de
Rib. Preto - Univ. São Paulo, Ribeirão Preto-SP, Brazil;
2
Fund. Hemocentro de Rib. Preto - Univ. São Paulo,
Ribeirão Preto-SP, Brazil
Verification Study of breast Cancer Biomarker
Candidates in Plasma Using Highly Multiplexed Peptide
immuno-MRM-MS; Regine M. Schoenherr1; Thomas
YK. Lau2; Michael A. Gillette2; Jeffrey R. Whiteaker1; Eric
Kuhn2; Lola Fagbami2; Jennifer Ross2; ChenWei Lin1; Pei
Wang1; Francisco J. Esteva3; Steven A. Carr2; Amanda G.
Paulovich1; 1Fred Hutchinson Cancer Research Center,
Seattle, WA; 2Broad Institute, Cambridge, MA; 3The
University of Texas MD Anderson Cancer Center, Houston,
TX
Applicability of Label-Free Selected Reaction
Monitoring for the Analysis of S100 Proteins in Cancer;
Juan Martinez-Aguilar1; Mark P. Molloy1, 2; 1Macquarie
University, Sydney, Australia; 2Australian Proteome Analysis
Facility, Sydney, Australia
Urinary Exosomes; A Source Of Biomarkers And Novel
Diagnostics For Polycystic Kidney Disease; Christopher
Ward; Kenneth Johnson; Marie Hogan; Roman Zenka;
Cristine Charlesworth; H. Robert Bergen, III; Mayo Clinic,
Rochester, MN

PAGE 76					

MP 547

MP 548

MP 549

Development of an UPLC-MRM Quantitation Method to
Monitor Pgp Expression Levels; Zhenlian Ke; Jocelyn
Yabut; Rena Zhang; Weixun Wang; Kevin Bateman; Bonnie
Howell; Christopher Gibson; Daniel Spellman; PPDM,
Merck Research Laboratories, West Point, PA
Comprehensive MS-based Quantification of Anthrax
Toxins Following Exposure to Bacillus anthracis; Adrian
R Woolfitt1; Anne E Boyer1; Maribel Gallegos-Candela1; Judith
Heitz2; Renato C Lins2; Katie Isbell1; Maria I Solano1; John R
Barr1; 1CDC, Atlanta, GA; 2Battelle Institute, Atlanta, GA
Successful Implementation of Multiple Reaction
Monitoring for the Validation of Tuberculosis
Biomarkers; Nicole Kruh-Garcia1; Gustavo Diaz1; Luke
Davis2; Jolynn Troudt1; Angelo Izzo1; Karen Dobos1;
1
Colorado State University, Fort Collins, CO; 2UCSF
Pulmonary & Critical Care Medicine, San Francisco, CA
Biomarker Discovery: Cancer, 550 - 567

MP 550

MP 551

MP 552

MP 553

MP 554

MP 555

MP 556

Identification of Proteins Associated with Activation
of Metastasis after Removal of Primary Tumor Using
Murine Ehrlich Carcinoma; Victoria Shender1; Rustam
Ziganshin1; Fedor Donenko2; Georgij Arapidi1; Sergey
Kovalchuk1; Vadim Govorun1; 1Institute of Bioorganic
Chemistry, RAS, Moscow, Russian Federation; 2N.N.
Blokhin Russian Cancer Research Center, Moscow,
Russian Federation
Imaging Mass Spectrometry to Uncover Proteomic
Differences in Mantle Cell Lymphoma Subtypes;
Kristina Schwamborn1, 2; Martina Rudelius1; Richard
Caprioli2; 1Technical University Munich, Munich, Germany;
2
Department of Biochemistry, Vanderbilt University,
Nashville, TN
Comparing Lung Protein Expression for Biomarkers
within the Disease Phenotypes of COPD and Lung
Cancer; Brian Sandri; Chris Wendt; University of
Minnesota, Minneapolis, MN
Proteomic Profiling and Characterization of Human
Endometrial Cancer Cell-Derived Extracellular
Microvesicles; Emma Arigi1; Gloria Polanco1; Clemente
Aguilar-Bonavides1; Armando Varela-Ramirez1; Russell
Broaddus2; Igor Almeida1; 1University of Texas at El Paso,
El Paso, TX; 2University of Texas MD Anderson Cancer
Center, Houston, TX
Identification of SRL Binding Receptors on human
Colon Cancer Cells Using Micro-Fluidic Based LC
System with an Advanced QTOF MS; Ravindra Gudihal2;
Sachin M. Eligar1, 3; Srikanth Barkeer1; Jonathan M.
Rhodes3; Lu-Gang Yu3; Bale M. Swamy1, 3; Shashikala
R. Inamdar1, 3; 1Dept of Studies in Biochemistry,Karnatak
Univ, Dharwad, India; 2Agilent Technologies India Pvt. Ltd,
Bangalore, India; 3Department of Gastroenterology,Univ of
Liverpool, Liverpool, UK
Proteomics Study of Synergistic Effects of
Combinational Treatment for Pancreatic Cancer; JinGyun Lee; Kimberly Q. McKinney; Jean-Luc Mougeot;
Herbert L. Bonkovsky; Sun-Il Hwang; Carolinas Healthcare
System, Charlotte, NC
Gastric Cancer Detection by Serum Glycan Signatures;
Sureyya Ozcan1; Cara Cooke2; Donald Barkauskas3;
Hyun Joo An4; Serenus Hua4; Cynthia Williams1; Lauren
Dimapasoc1; L. Renee Ruhaak1; Jae Han Kim4; David
Rocke5; Javier Torres6; Carlito B Lebrilla1; Jay V Solnick2;
1
UC Davis Chemistry Department, Davis, CA; 2UC Davis,
Center for Comparative Medicine, Davis, CA; 3University of
Southern California, Los Angeles, CA; 4Chungnam National
University, Daejeon, Korea; 5University of California, Davis,
CA; 6Instituto Mexicano del Seguro Social, Mexico, Mexico

61ST ASMS CONFERENCE ON MASS SPECTROMETRY

MONDAY POSTERS

MP 557

MP 558

MP 559

MP 560

MP 561

MP 562

MP 563

MP 564

MP 565

MP 566

MP 567

Functional Proteomic Analysis of KIAA1199
Overexpression in Breast Cancer; Hong Peng1;
Mohammad-Saeid Jami1; Jinxuan Hou2; Miao Liu1; Michelle
Varney1; Rakesh Singh1; Shi-Jian Ding1; 1Univ of Nebraska
Med Center, Omaha, NE; 2Zhongnan Hospital of Wuhan
University, Wuhan, China
Bladder Cancer Proteome: A Multiplexing Approach
Using Online 2D RP-RP Chromatography Coupled with
Data Independent Ion Mobility; Lee A Gethings1; Zhuowei
Wang2; Bo Wen3; Ju Zhang3; Quanhui Wang3; Liang Lin3;
Chris Hughes1; Johannes P.C. Vissers1; James Langridge1;
Siqi Liu3; 1Waters Corporation, Manchester, UK; 2Waters
(China), Beijing, China; 3BGI, Beijing, China
The Application of MALDI-TOF MS Plasma Protein
Profiling for Discrimination of Patients with Gastric
Cancer from Healthy Controls; Natalia Arnotskaya; Valeriy
Shevchenko; Elena Ogorodnikova; Mikhail M Davidov;
Maksat Ibraev; Igor Turkin; Mikhail I Davidov; N. N. Blokhin
Russian Cancer Research Center, Moscow, Russian
Federation
Identification of Candidate Lung Cancer Biomarkers by
Proteomics Analysis of Conditioned Media of Two Lung
Cancer Cell Lines; Valeriy Shevchenko; Sergei Kovalev;
Natalia Arnotskaya; Sergei Aushkap; Igor Kudryavtsev;
N. N. Blokhin Russian Cancer Research Center, Moscow,
Russian Federation
Discovery of Glycoprotein Biomarkers for
Differentiation of Pancreatic Cancer from Several
Related Conditions by Lectin Array and Quantitative
Mass Spectrometry; Song Nie1; Andy Lo1; Mack T. Ruffin2;
Kerby A. Shedden3; David M. Lubman1; 1Department
of Surgery, University of Michigan, Ann arbor, MI;
2
Epidemiology Department,University of Michigan, Ann
arbor, MI; 3Biostatistics Department,University of Michigan,
Ann arbor, MI
A Label-Free Shotgun Proteomic Characterization of
Multiple Myeloma Derived Extracellular Vesicles; Sean
W. Harshman; Alessandro Canella; Paul D. Ciarlariello;
Kitty Agarwal; Tiffany Talabere; Michael E. Paulaitis; Don M.
Benson, Jr; Flavia Pichiorri; Michael A. Freitas; Ohio State
University, Columbus, OH
GC/MS-based Metabolomic Profiling for Early
Diagnosis of Pancreatic Cancer; Masaru Yoshida;
Takashi Kobayashi; Shin Nishiumi; Yoshihiro Izumi; Atsuki
Matsubara; Takeshi Azuma; Kobe University, Kobe, Japan
N-linked Glycoproteomic Landscape of Human
Lymphoid Cancers; Venkatesha Basrur; Delphine Rolland;
Damian Fermin; Carla McNeil-Schwalm; Kevin Conlon;
Thomas Wolfe; Chih-Chiang Tsou; Yoon-Kyung Jeon; Noah
Brown; Dafydd Thomas; Nathanael Bailey; Gilbert Omenn;
Alexey Nesvizhskii; Megan Lim; Kojo Elenitoba-Johnson;
University of Michigan, Ann Arbor, MI
Quantitative Proteomics Reveals Hypoxia Perturbed
Pathways and Secretome that Promote Tumour
Angiogenesis, Metastasis, and Therapy Resistance; Siu
Kwan Sze; Yan Ren; Bama Dutta; Nanyang Technological
University, Singapore, Singapore
Efforts Toward Molecular Classification of Prostate
Cancer Tumors via Laser Capture Microdissection
Coupled to LC MS/MS; Michael Bereman; Martine
Roudier; Lawrence True; Michael MacCoss; Univ of
Washington, Seattle, WA
Decreased Glucose-Regulated Protein 78 in
Thioacetamide-Induced Liver Fibrosis Plays Crucially
in the Development of Liver Fibrosis: A Proteomic
Study; Jungshan Chang1; Chun-Chia Cheng2; Fu-Der Mai1;

Chun-Chao Chang3; 1Taipei Medical University, Taipei City,
Taiwan; 2Institute of Nuclear Energy Research, Taoyuan,
Taiwan; 3Taipei Medical University Hospital, Taipei, Taiwan
Immunology, 568 - 575
MP 568

MP 569

MP 570

MP 571

MP 572

MP 573

MP 574

MP 575

Multiplex Quantitative Proteomics Characterization of
the Activation of Human CD4+ T-cells; Robert Moulder;
Tapio Lönnberg; Anne Rokka; Riitta Lahesmaa; Turku
Centre for Biotechnology, Turku, Finland
Mechanistic Insights into E1B 55kDa-mediated
Regulation of the Innate Immune Response; George
Hung1; Jasdave S. Chahal2; Caroline DeHart1; David
H. Perlman3; S. J. Flint1; 1Dept. of Molecular Biology,
Princeton University, Princeton, NJ; 2Whitehead Institute for
Biomedical Research, MIT, Cambridge, MA; 3Proteomics
and Mass Spec. Core, Princeton Univ., Princeton, NJ
Interleukin 6: A Deterrent or an Indicator of
Mycobacterium Infection in the Endangered WhiteWinged Wood Duck; Anita Iveljic; Pyi Saw; Jody M.
Modarelli; Hiram College, Hiram, OH
Characterization of Phagosomal Proteomes in Activated
Macrophages; Manman Guo1; Marek Gierlinski 2; Brian
Dill1; Matthias Trost1; 1MRC-University of Dundee, Dundee,
UK; 2BCDD-University of Dundee, Dundee, UK
Identification of Naturally Processed “Self” and HIV
Derived MHC Class I Ligands Presented by Healthy
and HIV-Infected Cells; Marijana Rucevic1; Mariko
Shimada1; Georgio Kourjian1; Nicole Lai1; Carl Kadie2; David
Heckerman2; Bruce D. Walker1, 3; Sylvie LeGall1; 1Ragon of
MGH, MIT and Harvard, Boston, MA; 2Microsoft Research,
Los Angeles, CA; 3Howard Hughes Medical Institute, Chevy
Chase, MD
Impactof Genomic Polymorphisms on the Human
MHC Class I Immunopeptidome; Dev Sriranganadane1,
4
; Diana Paola Granados1, 5; Céline Laumont1, 5; Tariq
Daouda1, 2; Olivier Caron-Lizotte1; Antoine Zieger1, 2;
Sébastien Lemieux2; Claude Perreault1, 3; Pierre Thibault1, 4;
1
University of Montreal-IRIC, Montreal, Canada; 2University
of Montreal- IRIC Bioinformatics, Montreal, Canada; 3Div.
of Hematology Hôpital Maisonneuve-Rosemont, Montreal,
Canada; 4University of Montreal- Dept of Chemistry,
Montreal, Canada; 5University of Montreal- Dept of
Medicine, Montreal, Canada
Protein Composition, Stoichiometry, and Mass
Estimation of the HHV-6B Z29 Viral Particle Using Label
Free Quantitative Proteomics; Scott A. Shaffer; Aniuska
Becerra-Artiles; Karin M. Green; Stephanie A. Maniatis;
J. Mauricio Calvo-Calle; Lawrence J. Stern; University of
Massachusetts Medical School, Worcester, MA
Optimizing the Multiplexing Strategy for Quantitative
Proteomics Analysis of Immune Cell Subsets Using
iTRAQ; Parimal Samir; Kristen Hoek; Leigh Howard; Tara
Allos; Xinnan Niu; Clarence Creech; Kathryn Edwards;
Andrew Link; Vanderbilt University School of Medicine,
Nashville, TN
Molecular Systems Biology and Disease, 576 - 603

MP 576

Breaking the Habit: A Comprehensive, Proteome-Wide
Comparison of Chemical and Physical Synchronization
of the Mammalian Cell Cycle; Tony Ly; Angus Lamond;
Wellcome Trust Centre for Gene Regulation and Expr,
Dundee, UK

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INFORMATION

MP 577

MP 578

MP 579

MP 580

MP 581

MP 582

MP 583

MP 584

MP 585

MP 586

MP 587

MP 588

Dynamic Changes in Protein and mRNA Expression
Drive Functional Reprogramming during Osteoclast
Development from Monocyte-Macrophage Lineage
Cells; Eunkyung An; Manikandan Narayanan; Ronald
Germain; Aleksandra Nita-Lazar; NIH/NIAID/LSB,
Bethesda, MD
Mass Spectrometric Strategies to Characterize and
Understand Complex Microbial Biofilms - Applications
to Fuel Degradation and to Biocorrosion; Jan Sunner;
Iwona Beech; Joe Suflita; University of Oklahoma, Norman,
OK
Yeast on a Diet: Dextrose or Lactate, What’s Your
Favorite Carb? Alejandro Cohen1; J. Pedro FernandezMurray2; Christopher McMaster2; 1Proteomics Facility.
Dalhousie University, Halifax, Canada; 2Dalhousie
University, Halifax, Canada
System Wide Analysis of Lysine Acetylation in the
Human Pathogen Mycoplasma pneumoniae; Marco
Hennrich; Vera van Noort; Peer Bork; Anne-Claude Gavin;
EMBL Heidelberg, Heidelberg, Germany
First Draft of the Human Proteome; Mathias Wilhelm1;
Judith Schlegl2; Amin Moghaddas Gholami1; Hannes
Hahne1; Joos-Hendrik Boese2; Marcus Lieberenz2; Mikhail
Savitski3; Yuval Morad2; Lars Butzmann2; Emanuel
Ziegler2; Anton Niadzelka2; Eyk Kny2; Helmut Cossmann2;
Siegfried Gessulat2; Marcus Bantscheff3; Anja Gerstmair2;
Franz Faerber2; Bernhard Kuster 1; 1Technical Universitiy
Munich, Freising, Germany; 2SAP AG, Walldorf, Germany;
3
Cellzome, Heidelberg, Germany
The First Draft of the Human Proteome Enables
Systematic Analyses of Protein Expression; Hannes
Hahne1; Mathias Wilhelm1; Amin Moghaddas Gholami1;
Judith Schlegl2; Joos-Hendrik Boese2; Marcus Lieberenz2;
Mikhail Savitski3; Yuval Morad2; Lars Butzmann2; Emanuel
Ziegler2; Anton Niadzelka2; Eyk Kny2; Helmut Cossmann2;
Siegfried Gessulat2; Marcus Bantscheff3; Anja Gerstmair2;
Franz Faerber2; Bernhard Kuster1; 1Technische Universitaet
Muenchen, Freising, Germany; 2SAP AG, Walldorf,
Germany; 3Cellzome, Heidelberg, Germany
A Comprehensive Characterization of the Pig Islet
Proteome: PTMs, Amino Acid Substitutions and Novel
Isoforms; Ebbing de Jong; Bernhard Hering; Pratik Jagtap;
John Chilton; Getiria Onsongo; Timothy Griffin; University of
Minnesota, Minneapolis, MN
Analysis of the Impact of a Perturbed Metabolism on
Enzymes Controlling Adipocyte Metabolism; William
K. Russell; KyungOh Choi; Arul Jayaraman; Texas A&M
University, College Station, TX
Global Proteome Analysis of the NCI-60 Cell Line Panel;
Amin Moghaddas Gholami; Hannes Hahne; Zhixiang Wu;
Florian Auer; Chen Meng; Mathias Wilhelm; Bernhard
Kuster; Technical Universitiy Munich, Freising, Germany
Global and Targeted Proteomics of Nonstandard Amino
Acid Incorporation into Proteins and Proteomes; Hans
Rudolf Aerni1, 2; Patrick O’Donoghue3; Svetlana Rogulina1,
2
; Mark Shifman4; Jesse Rinehart1, 2; 1Yale Univ. School of
Medicine, New Haven, CT; 2Yale Systems Biology Institute,
West Haven, CT; 3Molecular Biophysics and Biochemistry,
New Haven, CT; 4Keck Biotechnology Resource Laboratory,
New Haven, CT
System-wide Analysis of Protein Degradation Using
Quantitative Proteomics; Romain Christiano; Xiuling Guo;
Tobias C. Walther; Yale University, New Haven, CT
Progress towards Real-Time Cell Secretome Analysis
by Mass Spectrometry; Rafael Montenegro Burke1; Jeffrey
Enders1; Kevin Seale2; John Wikswo3; John McLean1;
1
Department of Chemistry, Vanderbilt University, Nashville,

PAGE 78					

MP 589

MP 590

MP 591

MP 592

MP 593

MP 594

MP 595

MP 596

MP 597

MP 598

MP 599

MP 600

TN; 2Dep. Biomedical Engineering, Vanderbilt University,
Nashville, TN; 3Dept. Physics and Astronomy, Vanderbilt
University, Nashville, TN
Molecular Characterization of Rough Endoplasmic
Reticulum Subproteome in Pancreatic Beta Cells;
Xuequn Chen; Jin-sook Lee; Jingye Fang; Wayne State
University, Detroit, MI
The Proteomics of Dietary Restriction: Are Sex-Specific
Fitness Effects Mediated by Differential Protein
Expression? Simin Maleknia; Elizabeth Cassidy; Russell
Bonduriansky; University of New South Wales, Sydney,
Australia
Characterizing the Role of Caspases in Apoptosis
Induced by Endoplasmic Reticulum Stress; Veronica
Anania; Han Li; Diana Jeon; Avi Ashkenazi; Jennie Lill;
Genentech, Inc., South San Francisco, CA
Effect of Western Diet on Lipoprotein Mediated
Atherosclerosis. 2H2O-metabolic Labeling Based
Dynamic Proteomics Approach; Ling Li1; Stephen
Previs2; Arthur McCullough3; Belinda Willard1; Takhar
Kasumov3; 1Department of Core Service, Cleveland
Clinic, Cleveland, OH; 2Case Western Reserve University,
Cleveland, OH; 3Department of Hepatology, Cleveland
Clinic, Cleveland, OH
Identification of HLA-DR Presented Peptides in
Synovial Fluid from a Patient with Antibiotic-refractory
Lyme Arthritis; Qi Wang1; Elise E. Drouin2; Allen C.
Steere2; Catherine E. Costello1; 1Boston University, Boston,
MA; 2Massachusetts General Hospital, Boston, MA
Proteomic Investigation of the Tumor Differentiation
Factor (TDF)-induced Cell Differentiation; Armand
Ngounou; Izabela Sokolowska; Pinguang Yang; Urmi Roy;
Alisa Woods; Costel Darie; Clarkson University, Potsdam, NY
Dissecting Ageing-Related Disease by Studying Protein
Changes after Calorie Restriction; Mark Larance; Ehsan
Pourkarimi; Anton Gartner; Angus Lamond; University of
Dundee, Dundee, UK
Global In-Depth Quantitative Proteomic Analysis
of HIV Infected Cells Using a Novel Q-OT-qIT Mass
Spectrometer; Shannon Eliuk1; Jeffrey Johnson2; Leonard
Chavez3; Vlad Zabrouskov1; Christopher Mullen1; Eric
Verdin3; Nevan Krogan2; 1Thermo Fisher Scientific, San
Jose, CA; 2UCSF, San Francisco, CA; 3Gladstone Institute,
San Francisco, CA
Proteomics and Glycomics of Glioma-Derived StemLike Cells Correlated to Gene Expression Data and
Patient Outcomes; Carol L. Nilsson 1; Huiling Liu1;
Cheryl F. Lichti1; Mark R. Emmett1; Norelle C. Wildburger1;
Alexander S. Shavkunov1; Huan He3; Alan G. Marshall5;
Roger A. Kroes4; Joseph R. Moskal4; Erik P. Sulman2;
Frederick F. Lang2; Charles A. Conrad2; 1UTMB, Galveston,
TX; 2The University of Texas M. D. Anderson Cancer Ctr,
Houston, TX; 3Ion Cyclotron Resonance Program, NHMFL,
Tallahassee, FL; 4Falk Center for Molecular Therapeutics,
Evanston, IL; 5Department of Chemistry & Biochemistry,
FSU, Tallahassee, FL
Proteomics Based Investigation of Cystic Fibrosis
Cell-Line Models - A Step towards Understanding the
Disease Process; Navin Rauniyar; Vijay Gupta; William E.
Balch; John R. Yates; The Scripps Research Institute, La
Jolla, CA
Multi-omic Analysis of ApoE Isoform Effects in ADvulnerable Brain Regions; Tal Nuriel; Columbia University
Medical Center, New York, 0
Quantitative Proteome Turnover in C. elegans; Krishna
Vukoti; John Feng; Masaru Miyagi; Case Western Reserve
University, Cleveland, OH

61ST ASMS CONFERENCE ON MASS SPECTROMETRY

MONDAY POSTERS

MP 601

MP 602

MP 603

Analysis of BDNF-triggered Protein Translation Using
BONCAT and SILAC; Guoan Zhang; Heather Bowling; Eric
Klann; Moses Chao; Thomas Neubert; New York University,
New York, NY
Strategies for Interactome Tracking and Scoring: How
ProHits and SAINT Complement Strong Experimental
Designs; Guomin Liu1; Hyungwon Choi2; Jianping Zhang1;
Zhen-Yuan Lin1; Brett Larsen1; Mike Tyers3; Brian Raught4;
Alexey Nesvizhskii5; Anne-Claude Gingras1; 1Samuel
Lunenfeld Research Institute, Mount Sinai H, Toronto,
Canada; 2Saw Swee Hock School of Public Health, National
University of Singapore, Singapore; 3Université de Montréal,
Montréal, Canada; 4Ontario Cancer Institute, Toronto,
Canada; 5University of Michigan, Ann Arbor, MI
Application of Proteomics to the Characterization of
Deformation of Nautilus Pompilius Shell in Captivity;
Timothy P. Cleland; Mehdi Moini; Smithsonian Institution,
Suitland, MD

MP 613
MP 614

MP 615

MP 616

Forensics, 604 - 628
MP 604

MP 605

MP 606

MP 607

MP 608

MP 609

MP 610
MP 611

MP 612

Primate & Other Species Identification by Proteomic
Analysis; Heyi Yang; Bo Zhou; Mechthild Prinz; Donald
Siegel; Office of Chief Med Exam, New York, NY
Effect of Aging and Radiation on Museums’
Proteinaceous Specimens at Molecular Levels; Mehdi
Moini; Raquel Fleskes; Christopher Rollman; Smithsonian
Institution, Suitland, MD
A Multi-Platform Strategy Applied to the Detection and
Characterization of Falsified Artemisinin Combination
Therapies; Prabha Dwivedi1; Maria Julia Culzoni1;
Mohamed El-Sherbiny2; Obinna Onwujekwe3; Ogochukwu
Ezeoke3; Naiela Malik2; Ifeyinwa Fadeyi2; Harparkash Kaur2;
Facundo M. Fernández1; 1Georgia Institute of Technology,
Atlanta, GA; 2London School of Hygiene and Tropical
Medicine, London, UK; 3College of Medicine, University of
Nigeria, Enugu, Nigeria
Identification and Attribution Profiling of Chemical
Threat Agents Using Liquid Chromatography-Mass
Spectrometry Applied to Amanita Toxins in Food; Daniel
Jansson; Sten-Åke Fredriksson; Calle Nilsson; Swedish
Defence Research Agency, Umeå, Sweden
Assessment of Decontamination Protocols on the
Analysis of Hair by Multi-Modal Mass Spectrometry
Imaging; Bryn Flinders1; Tiffany Porta2; Emmanuel Varesio
2
; Gerard Hopfgartner2; Ron M.A. Heeren1; 1FOM Institute
AMOLF, Amsterdam, The Netherlands; 2University of
Geneva, Geneva, Switzerland
New Methods and Algorithms Using AllIons-MS/MS
Data for the Identification of Isomeric Drugs/DrugMetabolites in Blood Samples by LC-MS/MS AccurateMass-Quadrupole-Time-Of-Flight-Mass-Spectrometry;
Martin Josefsson1; Bernhard Wuest2; Markus Roman1;
1
National Board of Forensic Medicine, Linköping, Sweden;
2
Agilent Technologies GmBH, Waldbronn, Germany
Human Scent Differentiation; Elizabeth Magnuson;
Douglas J. Beussman; St. Olaf College, Northfield, MN
Bulk versus LC-IRMS Amino-Acid-Specific Isotopic
Analysis of Human Hair; Yan An1; Ayat Bani Rashaid1;
Glen P. Jackson2; 1Ohio University, Athens, OH; 2West
Virginia University, Morgantown, WV
Rapid LC-MS/MS Screening Method for Forty-Three
Phosphodiesterase Type 5 Inhibitors and Six Flavone
Drugs in Counterfeit Samples; Philippe Lebel; Karen
C. Waldron; Alexandra Furtos; Université de Montréal,
Montréal, Canada

MP 617

MP 618

MP 619

MP 620

MP 621

MP 622

MP 623

MP 624

MP 625

Detection of Metabolites of Drugs in Wastewater of
Lubbock, TX; David Klein; Texas Tech University, Lubbock, TX
The Detection of Pseudo-Endogenous Androgenic
Anabolic Steroids in Sports by Isotope Ratio Mass
Spectrometry: A Global Sample Purification Strategy;
Xavier De La Torre; Cristiana Colamonici; Davide Curcio;
Francesco Molaioni; Francesco Botrè; Laboratorio
Antidoping FMSI, Rome, Italy
An Improved and Accurate Method for the Analysis
of Testosterone Related Urinary Metabolites Using
Gas Chromatography-Combustion-Isotope Ratio
Mass Spectrometry; Alexandre Ouellet; Nicolas LeBerre;
Christiane Ayotte; INRS-IAF-Doping Control Laboratory,
Laval, Canada
Identification Tree Based on Fragmentation Rules
for Structure Elucidation of Organophosphorus
Esters by Electrospray Mass Spectrometry; Adrián
Schwarzenberg1; Farid Ichou1; Richard B. Cole1; Xavier
Machuron-Mandard2; Christophe Junot3; Denis Lesage1;
Jean-Claude Tabet1; 1UPMC/IPCM, UMR-CNRS 7201,
Paris, France; 2CEA, Centre DAM/DIF Ile-de-France,
Arpajon, France; 3CEA, DSV/iBiTec-S, Saclay, France
High Resolution and Accurate Mass Forensic
Toxicology Screening in PlasmaBlood Sample Using
Q Exactive Mass Spectrometer; Isabelle Morel2; Sylvie
Lepage2; Benedicte Duretz1; 1Thermo Fisher, Courtaboeuf,
France; 2Forensic and Toxicology Laboratory, Rennes, France
Identification of Dyes Directly From Textile Fibers Using
Infrared Matrix-Assisted Laser Desorption Electrospray
Ionization (IR-MALDESI) Coupled to FT-ICR-MS; Kristin
H. Cochran; Jeremy A. Barry; Guillaume Robichaud; David
C. Muddiman; North Carolina State University, Raleigh, NC
Differentiation of Cotton Fibers Using Isotope Ratio
Mass Spectrometry; Kristi Gangelhoff; Douglas J.
Beussman; St. Olaf College, Northfield, MN
Characterization of the Photodegradation of Crystal
Violet by LDI-TOF-MS; Megan Czerniejewski; Gary Kinsel;
Southern Illinois University, Carbondale, Illinois
Utilization of DART Ion Source Coupled with HR/AM
Q-Orbitrap MS for Car Paint Component Identification
for Traffic Accident Criminal Investigation; Wei-Shun
Lai1; Tai-Hung Chen2; Hsin-Hung Huang1; Shu-Hui Lee1;
1
Mass Solutions Technology, New Taipei, Taiwan; 2Criminal
Investigation Brigade, Taipei, Taiwan
Using a Portable Mass Spectrometer for Direct
Screening of Arson and Clandestine Drug Laboratory
Evidence; Seth E. Hall; Adam E. O’Leary; Kyle E. Vircks;
Christopher C. Mulligan; Illinois State University, Normal, IL
Beyond the Ridge Pattern - Multi Informative
Analysis of Latent Fingermarks by MALDI Mass
Spectrometry; Robert Bradshaw1; Leesa Ferguson1;
Rosalind Wolstenholme1; Malcolm Clench1; Wei Rao2;
Stephen Bleay3; Simona Francese1; 1BMRC, Sheffield, UK;
2
University of Nottingham, Nottingham, UK; 3CAST, Home
Office, St Albans, UK
Towards a Versatile Mass Spectrometric Platform for
Comprehensive Crime Scene Analytics; Christopher
Mulligan; Seth Hall; Adam O’Leary; Kyle Vircks; Jamie
Wieland; Illinois State University, Normal, IL
Detection, Quantification and Identification of
Dermorphin in Equine Plasma and Urine by LC-MS/
MS for Doping Control; Fuyu Guan1, 3; Cornelius Uboh2;
Lawrence Soma1, 3; Mary Robinson1, 3; George Maylin4;
Xiaoqing Li1, 3; 1University of Pennsylvania, West Chester,
PA; 2Pennsylvania Equine Toxicology and Research Center,
West Chester, PA; 3University of Pennsylvania, Kennett
Square, PA; 4Morrisville College, Ithaca, NY

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GENERAL
INFORMATION

MP 626

MP 627

MP 628

Detection of Efaproxiral (RSR13) and Its Metabolites
in Equine by Liquid Chromatography Tandem Mass
Spectrometry; Rong Yi; Jasmeet Sandhu; Sarah Zhao;
Geoffrey Lam; Devan Loganathan; Barbara Morrissey;
MAXXAM Analytics, Burnaby, BC, Canada
Development of a Broad Range Screen, Utilising UPLCMSMS,UPLC-Orbitrap and GC-MSMS for Drug Detection
in Equine Hair Samples; Bob Gray; Jane Bright; Marjaana
Viljanto; Suzanne Lister; Steve Maynard; HFL Sport
Science, Fordham, UK
Identification and Quantification of an Opioid Peptide
(Dermorphin) in Biological Matrix Using Liquid
Chromatography Tandem Mass Spectrometry; Daniel
McKemie; Scott Stanley; Heather Knych; University of
California, Davis, CA

MP 637

MP 638

MP 639

Environmental Analysis: General I, 629 - 652
MP 629

MP 630

MP 631

MP 632

MP 633

MP 634

MP 635

MP 636

QTOF Analysis and Sample Profiling for Environmental
Applications; Sylvain Merel; Tarun Anumol; Ai Jia; Shane
Snyder; University of Arizona, Tucson, Az,
Comparative PCDD/F Analysis with GC-HRMS,
GC-HRTOFMS and GCxGC-TOFMS: Discovery of
Compounds Not Found in Environmental Analysis
Guided by EPA 1613B; Peter Gorst-Allman1; David E
Alonso2; Jayne de Vos3; Jack Cochran4; Eric Reiner5; 1Leco
Africa, Kempton Park, Gauteng, RSA; 2LECO Corporation,
Saint Joseph, MI; 3National Metrology Institute of South
Africa, Pretoria, Gauteng, RSA; 4Restek Corporation,
Bellefonte, PA; 5Ontario Ministry of the Environment,
Toronto, Canada
Non-Target and Post-Target Analysis of Emerging
Halogenated Contaminants in American and European
Eels by Gas Chromatography-High Resolution Time-ofFlight MS; Jonathan Byer1; Grazina Pacepavicius2; Peter V.
Hodson3; Claude Belpaire4; David E Alonso1; Joe Binkley1;
Mehran Alaee2; 1LECO Corporation, St. Joseph, MI;
2
Aquatic Contaminants Research, Environment Canada,
Burlington, ON, Canada; 3Queen’s University, Kingston,
ON, Canada; 4Research Institute for Nature and Forest,
Groenendaal-Hoeilaart, Belgium
LC/MS/MS with Novel Online SPE Valving Solution for
the Analysis of Sub-Parts-Per-Trillion Contaminants in
Drinking Water; Sheher Bano Mohsin; Michael Woodman;
Agilent Technologies, Schaumburg, IL
Determination of Sucralose and Acesulfame in Source,
Tap and Bottled Waters; Jessica M. Boyd; Minghuo Wu;
Dylan Baustad-Thomas; Steve Hrudey; Xing-Fang Li;
University of Alberta, Edmonton, Canada
Determination of Odor Compounds in Surface Water
by Solid Phase Micro Extraction and Quadrupole Time
Of Flight Gas Chromatograph Mass Spectrometer;
Keun-Joo Choi 1; Yeanwoong You2; Seung-ju Yang2; 1Seoul
Waterworks Research Institute, Seoul, South Korea;
2
Agilent Technologies Korea, Ltd, seoul, korea
GCMS Approach towards the Characterization of
Metabolites Formed Due to Biodegradation of Nicotine
by a New Strain Pseudomonas plecoglossicida
TND35; Gurusamy Raman1; Mohan Kasi2; Saravanan
Subramaniyan2; Venkat Manohar2; Natarajan Sakthivel1;
1
Dept. of Biotechnology, Pondicherry University,
Puducherry, India; 2IICMS, Chennai, India
Simultaneous Determination of Bisphenol A,
Alkylphenols and Alkylphenol Ethoxylates in NIST SRM
2585 by GC/MS/MS; Xinghua Fan; Cariton Kubwabo; Fang
Wu; Health Canada, Ottawa, Canada

PAGE 80					

MP 640

MP 641

MP 642
MP 643

MP 644

MP 645

MP 646

MP 647

MP 648

The New Fast Approach for the Determination of
Semi Volatile Organic Compounds According to EPA
8270D; Ilaria Ferrante1; Daniele Recenti1; Luigi Motti2;
Chiara Abate1; 1DANI, Cologno Monzese, Italy; 2DANI SA,
Contone, Switzerland
EPA 8260: Dynamic Headspace Purge &Trap GC/TOFMS for VOCs Determination in Environmental Matrices;
Roberta Lariccia1; Ilaria Ferrante1; Daniele Recenti1; Luigi
Motti2; 1DANI, Cologno Monzese, Italy; 2Dani SA, Contone,
switzerland
Selective and Sensitive Detection and Quantification of
Stockholm Convention POPs, Including Dioxins, Using
Atmospheric Pressure Gas Chromatography MS/MS;
Kendon Graham1, 2; Jody Dunstan1, 2; Michael McCullagh1, 2;
Ingrid Ericson Jogsten3; Jessika Hagberg3; Bert van Bavel3;
1
Waters Corporation, Milford, MA; 2Waters Corporation,
Manchester, UK; 3MTM Research Centre, Orebro, Sweden
In situ Detection of Ambient Aerosol in Jiangmen,
China Using Single Particle Aerosol Mass
Spectrometry; Mei Li1; Li Zhang1; Lei Li1; Zhengxu Huang1;
Wei Gao1; Ping Cheng1; Zhen Zhou1; Zhong Fu2; Huiqing
Nian2; 1Shanghai University, Shanghai, China; 2Guangzhou
Hexin Analytical Instrument Company, Guangzhou, China
Air Quality Test Using Home-made Portable Membrane
Inlet Single Photon Ionization Time-of-flight Mass
Spectrometer; Guobin Tan1; Wei Gao1; Zhengxu Huang1;
Mei Li1; Ping Cheng1; Zhen Zhou1; Huiqing Nian2; Zhong
Fu2; 1Shanghai University, Shanghai, China; 2Guangzhou
Hexin Analytical Instrument Company, Guangzhou, China
Screening of Pesticides in Water Using SPE On Line;
Stefano Lucini; Stefano Zaza; Shimadzu, Milano, Italy
Method Development for Detection of Vinyl Chloride
from Water using Solid Phase Micro-extraction (SPME)
with Gas Chromatography/Mass Spectrometry (GC/
MS); Rachel Logemann; Christine N. Dalton; CarsonNewman College, Jefferson City, TN
Preliminary Analysis of Athabasca Samples Using
Gas Chromatography Atmospheric Pressure Chemical
Ionization Fourier Transform Ion Cyclotron Resonance
Mass Spectrometry; Mark Barrow1; Kerry Peru2;
John Headley2; 1University of Warwick, Coventry, UK;
2
Environment Canada, Saskatoon, Canada
Use of Non-Targeted Environmetrics and GCxGC-TOFMS to Assess the Sewage Treatment Plant Removal
Efficiency of Emerging Contaminants; Peter Haglund1;
Ulrika Olofsson1; Kevin Siek2; David Alonso2; 1Umea
University, Department of Chemistry, Umea, Sweden; 2Leco
Corp. Life Science & Chemical Analysis Center, St Joseph, MI
An Online VOCs Monitoring System Using Ion Trap
Based Gas Chromatography Mass Spectrometry
Technology; Luhong Wen1; Jiancheng Yu1; Xiaoxu Li2;
1
Ningbo University, Ningbo, China; 2Suzhou University,
Suzhou, China
Development of Methods on the Basis of Large-VolumeInjection Solid-Phase Extraction Hyphenated to Tandem
Mass Spectrometry for the Determination of Hormones;
Norbert Wenkel2; Thorsten Teutenberg1; Jochen Türk1;
Christoph Portner1; Linda Gehrmann1; Sandy-Dominic
Freihoff1; 1IUTA e.V., Duisburg, Germany; 2Axel Semrau
GmbH & Co. KG, Sprockhövel, Germany
FT-ICR MS Analysis of complex Mixtures Produced
by Pyrolysis of Plastics; Justin Elliott1; Alan T. Taylor1;
David Kilgour2; Meric Gursoy3; Pat Langridge Smith1;
Peter O’Connor2; Ondrej Masek3; Logan Mackay1; 1School
of Chemistry, University of Edinburgh, Edinburgh, UK;
2
Department of Chemistry, University of Warwick, Coventry,
UK; 3University of Edinburgh, Edinburgh, UK

61ST ASMS CONFERENCE ON MASS SPECTROMETRY

MONDAY POSTERS

MP 649

MP 650

MP 651

MP 652

Direct Analysis of Secondary Organic Aerosol
Using the Flowing Atmospheric-Pressure Afterglow
(FAPA) Ambient Mass Spectrometry source; Martin
Brüggemann; Thorsten Hoffmann; Johannes Gutenberg
University, Mainz, Germany
Elemental Composition Analysis of Biogenic Secondary
Organic Aerosol by FTMS; Jae-Eun Park1; Sun Jong
Baek1; Hyun Sik Kim1; Jun-Hyun Park2; Wongu Woo2; HoJin Lim2; 1Korea Basic Science Institute, Ochang-Myun
Cheongwon-Gun, South Korea; 2Kyungpook National
University, Daegu, South Korea
Combination of FTMS and DirectProbe(DIP) Analysis
of Complex Cigarette Smoke; Hu Nan1; Pu Hai1; Wu
Yiqin2; 1Bruker China, Beijing, China; 2Yunnan Academy of
Tobacco Science, Kunming, Yunnan, China
Molecular Characterization of Sedimentary Organic
Matter in the Estuary-Lagoon System Cananéia-Iguape
(Brazil) by Fourier Transform Ion Cyclotron Resonance
Mass Spectrometry; Giovana Bataglion1; Clécio Klitzke1;
Diego Senatore2; Roberto Barcellos3; Rolf Weber2; Marcos
Eberlin1; 1Unicamp, Campinas, Brasil; 2USP, São Paulo,
Brasil; 3UFPE, Recife, Brasil

MP 661

MP 662

MP 663

MP 664

Plant”omics”, 653 - 671
MP 653

MP 654

MP 655

MP 656

MP 657

MP 658

MP 659

MP 660

Mass Spectrometry Analysis of Redox Proteins in
Guard Cell Hormone Signaling; Mengmeng Zhu1; Ning
Zhu1; Wenyuan Song1; Alice Harmon1; Sarah Assmann2;
Sixue Chen1; 1University of Florida, Gainesville, FL;
2
Pennsylvania State University, State College, PA
Relative Mass Defect Filtering for Discovery of
Conjugated Terpenoid Metabolites from Complex Plant
Extracts; E.A. Prabodha Ekanayaka; A. Daniel Jones;
Michigan State University, East Lansing, MI
Unusual Fragmentation Patterns of Ionized Lignin
Model Compounds with α-O-4 Linkages in (+)/(-)-ESI/
Tandem Mass Spectrometry; Huaming Sheng; Purdue
University, West Lafayette, IN
Extraction Methodology and Metabolite Analysis by LCMS of Eucalyptus grandis, Resistant and Susceptible
to Puccinia psidii, Aiming for Identifying Resistance
Biomarkers; Thais Regiani; Felipe Garbelini Marques; Ilara
Gabriela Frasson Budzinski; Fabricio Edgar de Moraes;
Carlos Alberto Labate; Max Feffer Laboratory of Plant
Genetics, Piracicaba, Brazil
Comparative Metabolomic Studies on Portulaca
oleracea L. Using GC-MS and LC-MS; Li-Chun Liu; Qing
Wang; Ying Wang; Ming-Quan Guo; Wuhan Botanical
Garden, Chinese Academy of Science, Wuhan, China
Atmospheric Pressure Photoionization Combined with
UV Laser Desorption Mass Spectrometry; Katie-Jo
Galayda; Tim Anderson; Andrew Korte; Young-Jin Lee; R. S.
Houk; Iowa State University, Ames, IA
Application of Sub-2µm Particle CO2-based
Chromatography Coupled to Mass Spectrometry for
Chemical Profiling of Various Chamomiles; Bharathi
Avula1; Yan-Hong Wang1; Michael D Jones2; Larry Meeker2;
Kate Yu2; Troy J. Smillie1; Ikhlas A. Khan1, 3; 1University of
Mississippi, NCNPR, University, MS; 2Waters, Milford, MA;
3
Universty of Mississippi, School of Pharmacy, University,
MS
Detecting Substances in Tea Leaves by Live Single-cell
Mass Spectrometry; Iwao Sakane1; Yuko M Sagesaka1;
Hajime Mizuno2; Naohiro Tsuyama2; Takanori Harada3;
Tsutomu Masujima2; 1ITO-EN LTD, Mckinhohara, Japan;
2
RIKEN Quantitative Biology Center (QBiC), Osaka, Japan;
3
Hiroshima Univ. Grad. Sch. Biomed. Sci, Hiroshima, Japan

MP 665

MP 666

MP 667

MP 668

MP 669

MP 670

MP 671

Quercus ilex: Protein Identification Strategies for an
Orphan Tree Species; Christof Lenz1; Henning Urlaub1;
Jesús V. Jorrín Novo2; 1Max Planck Institute for Biophysical
Chemistry, Goettingen, Germany; 2University of Córdoba,
Córdoba, Spain
Characterization of Barley Chloroplast Proteins by
Quantitative Proteomics Using Optimized 2D-LC
Coupled to an LTQ-Orbitrap Velos Tandem Mass
Spectrometer; Jørgen Petersen1; Richard R. Sprenger1;
Adelina Rogowska-Wrzesinska1; Pai Pedas2; Ken
Krogholm2; Søren Husted2; Poul Erik Jensen2; Jan Kofod
Schjoerring2; Ole Nørregaard Jensen1; 1University of
Southern Denmark, Odense C, Denmark; 2University of
Copenhagen, Copenhagen, Denmark
Comparative Characterization of Carotenoid Regulatory
Network in Melon Using TMT-based Quantitative
Proteomics Analysis; Yong Yang1; Li Li1; Yongqiang
Wang2; Theodore.W. Thannhauser 1; 1USDA-ARS at Cornell
Universi, Ithaca, NY; 2Department of Plant Breeding and
Genetics,Cornell, Ithaca, NY
An Untargeted, Quantitative Comparison of Early ABAinduced Phosphoproteomic Changes Using Wildtype
and Quadruple ABA Receptor Mutant A. Thaliana
Strains; Benjamin Minkoff; University of Wisconsin,
Madison, WI
Integrating Multiple ‘omics’ Analysis of Fruit
Development in High-Yielding Oil Palm Mesocarp;
Huey Fang Teh; Sime Darby Technology Centre, Serdang,
Malaysia
Metabolite Profile of Sugarcane (SaccharumSpp) under
Water Stress; Simone Guidetti-Gonzalez; Ilara Gabriela
Frasson Budzinski; Fabricio Edgar de Moraes; Carlos
Alberto Labate; ESALQ/USP, Piracicaba, Brazil
The Effect of Genetics and Environment on the
Metabolome of Commercial Maize Hybrids Using LC/
MS: A Multisite Study; Vincent Asiago; Chris Vlahakis;
Hamid Baniasadi; Jan Hazebroek; Cathy Zhong; DuPont
Pioneer, Johnston, IA
Characterization of Cytosolic Protein Complexes in
Plants Using Multi-Step Chromatographic Separation
and Quantitative Mass Spectrometry; Uma Aryal1; Yi
Xiong2; Eileen Mallery3; Mark Hall1; Jun Xie4; Daisuke
Kihara2; Daniel Szymanski3; 1Department of Biochemistry,
Purdue University, West Lafayette, IN; 2Department of
Computer Science, Purdue University, West Lafayette,
IN; 3Department of Agronomy, Purdue University, West
Lafayette, IN; 4Department of Statistics, Purdue University,
West Lafayette, IN
Integrating Genomics, Transcriptomics, and Proteomics
for the Identification of Protein Sequence Variants in the
Genus Populus; Paul Abraham1, 2; Xiaojing Wang3; Priya
Ranjan2; Bing Zhang3; Gerald Tuskan2; Robert Hettich2;
1
University of Tennessee, Knoxville, TN; 2Oak Ridge
National Laboratory, Oak Ridge, TN; 3Vanderbilt University
School of Medicine, Nashville, TN
Stable Isotope Labeling of Brachypodium distachyon
with Nitrogen 15 for Quantitative Mass Spectrometry;
David Shearer1; Victor Spicer1; Steve Haber2; Kenneth
Standing1; 1University of Manitoba, Winnipeg, Canada;
2
Agriculture and Agri-Food Canada, Winnipeg, Canada
Absolute Quantification of TIR1/AFB Proteins in
Arabidopsis Using the QconCAT Strategy; Kai-Ting
Fan; Jerry D. Cohen; William M. Gray; Adrian D. Hegeman;
University of Minnesota, Twin Cities, MN

61ST ASMS CONFERENCE ON MASS SPECTROMETRY						

PAGE 81

MONDAY
POSTERS
GENERAL
INFORMATION

Agriculture, 672 - 682
MP 672

MP 673

MP 674

MP 675

MP 676

MP 677

MP 678

MP 679

MP 680

Coupling Genetics and Molecular Biology with
Mass Spectrometry Revealed Arboviruses Usurp
Similar Transport Pathways in Insect Vectors and
Hosts; Michelle Cilia1, 2; Michael Bereman3; Cecilia
Tamborindeguy4; Qiaoxia Shang2, 5; David Igwe2, 6; Stacy
Deblasio1; Theodore Thannhauser1; Stewart Gray1; Michael
MacCoss3; 1USDA-Agricultural Research Service, Ithaca,
NY; 2Plant Pathology, Cornell University, Ithaca, NY;
3
Genome Sciences, University of Washington, Seattle,
WA; 4Entomology, Texas A&M University, College Station,
TX; 5Beijing University of Agriculture, Beijing, China;
6
International Institute of Tropical Agriculture, Ibadan, Nigeria
Coupling a Simple, ELISA-based CoImmunoprecipitation Technique with Tandem
Mass Spectrometry to Characterize a Plant-Virus
Interactome; Stacy Deblasio1; Michael Bereman2; Jaclyn
Mahoney3; Theodore Thannhauser1; Stewart Gray1, 3;
Michael MacCoss2; Michelle Cilia1, 3; 1USDA-Agricultural
Research Service, Ithaca, NY; 2Genome Sciences,
University of Washington, Seattle, WA; 3Plant Pathology,
Cornell University, Ithaca, NY
Quantitation of Antiviral Drugs in Chicken Samples
by Ultra-High Performance Liquid Chromatography
Tandem Triple Quadrupole Mass Spectrometry with
Triggered MRM; Jianzhong Li; Tao Bo; Cuiling Wu; Wei
Chen; Zhixu Zhang; Agilent Technologies(China), Beijing,
China
Comparison of Proteomes from Escherichia coli Strains
that cause Transient and Persistent Intramammary
Infections; John Lippolis1; Timothy Reinhardt1; Randy
Sacco1; Brian Nonnecke1; Belgin Dogan2; Kenneth
Simpson2; Ynte Schukken2; 1USDA ARS - Nat’l Animal
Disease Ctr., Ames, IA; 2Cornell University, College of
Veterinary Medicine, Ithaca, NY
Fragmentation Patterns of Monomeric and Oligomeric
Wine Stilbenoids by UHPLC-ESI-QTOF MS; Ryan
Moss1; Qunyong Mao2; Dennis Taylor1, 2; Cédric Saucier1,
2 1
; University of British Columbia, Kelowna, Canada;
2
University of Adelaide, Adelaide, SA
Proteomic Analysis of the Effect of Pre-Sound Wave
Stimulation on Botrytis cinerea-infected Arabidopsis;
Yeong-Sang Kwon1; Sung Woo Jeong1; Hanhong Bae2;
Sung Chul Shin1; Mi-Jeong Jeong3; Soo-Chul Park3; DongWon Bae1; 1GyeongSang National University, Jinju, South
Korea; 2Yeungnam University, Gyeongsan, Korea; 3National
Academy of Agricultural Science, Suwon, Korea
Distribution of Metabolites and Biosynthesis in
a Cell of a Plant Tissue Analyzed by Live Singlecell Mass Spectrometry; Shuichi Mastuda1; Satomi
Hatano-Saga2; Sachiko Date2; Hajime Mizuno2; Naohiro
Tsuyama1; Tsutomu Masujima1, 2; 1Graduate School of
Biomedical,Hiroshima University, Hiroshima, Japan;
2
Quantitative Biology Center (QBiC), RIKEN, Suita, Japan
Analysis of Various Deoxynivalenol (DON) LC-MS
Methods without Acetate in the Mobile Phase; Sheldon
M. Williams; Yoko S. Johnson; Treeske Ehresmann;
Michele M. Swarbrick; Minnesota Department of
Agriculture, St Paul, MN
Stable Isotope Tracer Guided LC-MS Metabolomics to
Elucidate Biochemical Mechanisms of Temperature
Dependent Anthocyanin Degradation in Grapes
Cultured in vitro; Alexander Chassy1; Christoph Büschel2;
Hye-Young Lee1; Larry Lerno1; Anita Oberholster1; Daniela
Barile1; Rainer Schuhmacher2; Andrew Waterhouse1;
1
University of California, Davis, CA; 2University of Natural
Resources and Life Sciences, Vienna, Austria

PAGE 82					

MP 681

MP 682

Muscle, Marbling, maXis and Mascot - Meat Quality
Phenotyping; Stefan Clerens1; Santanu Deb-Choudhury1;
Anita Grosvenor1; Stephen Haines1; Ancy Thomas1;
Peter Dobbie2; Chris McMahon2; Monica Senna-Salerno2;
Gina Nicholas2; Shelley Falconer2; Katja Rosenvold2;
1
AgResearch Lincoln Research Centre, Christchurch,
New Zealand; 2AgResearch Ruakura Research Centre,
Hamilton, New Zealand
Quantitative Analysis of the Host-Pathogen Proteomics
of Israeli Acute Paralysis Virus (IAPV) Infection in
the Honey Bee (Apis mellifera); Sarah Natrasany1;
Humberto Boncristiani2; Leonard Foster1; 1University of
British Columbia, Vancouver, Canada; 2University of North
Carolina, Greensboro, NC
Natural Products, 683 - 714

MP 683

MP 684

MP 685

MP 686

MP 687

MP 688

MP 689

MP 690

MP 691

LC-MS/MS Study of Indian Ginseng Metabolism; Manoj
Pillai1, 2; Takeo Sakuma1, 2; Carmai Seto1, 2; 1AB SCIEX,
Gurgaon, India; 2AB SCIEX, Concord, Canada
Unknowns Analysis of Natural Products Using GC/QTOF and GC/IonTrap in Positive Electron Impact and
Positve Chemical Ionization Modes with MS/MS; Ron
Honnold; Rafael Acosta; Agilent Technologies, Santa Clara,
CA
Accurate Mass Retention Time Locked Flavor Database
by GC/Q-TOF; Susan E. Ebeler3; Sean LaFond3; Frank
David2; Stephan Baumann1; Tim Conjelko1; Sofia Aronova1;
1
Agilent Technologies, Inc., Santa Clara, CA; 2Research
Institute for Chromatography, Kortrijk, Belgium; 3UC Davis
Department of Viticulture and Enology, Davis, CA
Mass Spectrometric Characterization of Pyrrolizidine
Alkaloids in Black Cohosh; Dejan Nikolic; Guannan
Li; Tamara Cisowska; Tanja Goedecke; Shaon-Nong
Chen; David Lankin; Guido Pauli; Richard van Breemen;
University of Illinois College of Pharmacy, Chicago, IL
In-situ Measurement of the Defense Response of the
Sea Anemone to Spatial Encroachment Stresses Using
On-line LC/MS; James Buchner; Ross Willoughby; James
Buchner Jr; Robert Moskala; BiOMICom, Inc., Allison Park,
PA
Optimized Plant Extractions for Phytochemical Library
Construction: Evaluating Solvent Systems Using
Metabolomics Approaches; Amanda C. Martin; Alison D.
Pawlus; Erin Jewet; Stephen Brockman; Donald L. Wyse;
Adrian D. Hegeman; University of Minnesota, Saint Paul,
MN
Identification of Antibacterial Component from
Extract of Garcinia indica Fruit Rind Using LC/MS/
MS; Shailendra Rane1; Shailesh Damale1; Shruti Raju1;
Rashi Kochhar1; Deepti Bhandarkar1; Ajit Datar1; Pratap
Rasam1; Jitendra Kelkar1; Manasi Kher2; Komal Barbade2;
1
Shimadzu Analytical (India) Pvt. Ltd., Andheri (E), Mumbai,
Maharashtra, India; 2G.N.I.R.D., G.N. Khalsa College,
Matunga, Mumbai, Maharashtra, India
Study of Antibacterial Activity of Essential Oil
Components Obtained from Pericarp of Zanthoxylum
rhetsa (Indian origin) Using HS-GCMS; Durvesh Sawant1;
Dheeraj Handique1; Ankush Bhone1; Prashant Hase1;
Sanket Chiplunkar1; Jitendra Kelkar1; Ajit Datar1; Pratap
Rasam1; Nital Patil2; 1Shimadzu Analytical (India) Pvt. Ltd.,
Andheri (E), Mumbai, Maharashtra, India; 2G.N.I.R.D., G.N.
Khalsa College, Matunga, Mumbai, Maharashtra, India
Characterization of Flavonoids and Phytoestrogens
in an Extract of Pueraria Mirifica by UHPLC-MS-MS;
Jeff Dahl1; Rocky Graziose2; Youssef W. Mirhom2; Frank
S. D’Amelio2; 1Shimadzu, Columbia, MD; 2Bio-Botanica,
Hauppauge, NY

61ST ASMS CONFERENCE ON MASS SPECTROMETRY

MONDAY POSTERS

MP 692

MP 693

MP 694

MP 695

MP 696

MP 697

MP 698

MP 699

MP 700

MP 701

MP 702

Alkaloids Characterization of Tabernaemontana
catharinensis by ESI-Orbitrap; Sidnei Moura; Flávio
Marinho; Carla Nicola; Mariana Roesch-Ely; Caxias do Sul
University, Caxias do Sul, Brazil
Fragmentation Study and Comprehensive Profiling of
Escin, a Mixture of Triterpene Saponins from Aesculus
Hyppocastanum, by LC-MS/MS; Antonio Triolo1; Elisa
Libralesso1; Serena Staccioli2; Fabiana Tavani2; 1Menarini
Ricerche Spa, Firenze, ITALY; 2A. Menarini Manufacturing
Logistics and Services, Firenze, Italy
High Resolution UPLC-TOF Mass Spectrometric
Characterization of an Herbal Preparation of Senna;
Tiffany A. Freed1; Melanie A. Rehder Silinski1; James
C. Blake1; Megan Grabenauer1; Reshan A. Fernando1;
Veronica G. Robinson2; Suramya Waidyanatha2; 1RTI
International, Research Triangle Park, NC; 2Division of
National Toxicology Program, NIEHS, Research Triangle
Park, NC
Characterization of Commercially Available Steviaderived Sweeteners Using Liquid ChromatographyHigh Resolution Time of Flight Mass Spectrometry and
Advanced Data Processing; Juergen Wendt1; Norbert
Helle2; Jutta Lintelmann3; Jeffrey S. Patrick4; 1LECO
European LSCA Centre, Moechengladbach, Germany;
2
TeLA GmbH, Bremerhaven, Germany; 3Helmholtz Zentrum
München, Neuherberg, Germany; 4LECO Corporation,
Separation Sciences Division, St. Joseph, MI
Quality-by-Design UHPLC Method Development with
High Resolution MSE for Biomarker Identification
of Phyllanthus Species; Amadeu Iglesias1; Ricardo
Sprenger2; Fernando de Paula1; Tiago Campos1; Michael
Murgu1; Quezia Cass2; 1Waters Corporation, Barueri, Brazil;
2
Universidade Federal de São Carlos - UFSCar, São Carlos,
SP, Brazil
Structural Elucidation of Iridoids from the Leaves of
Vitex negundo Linn. by Liquid Chromatography-Tandem
Mass Spectrometry; Lolita A. Lagurin1; Maria Cristina A.
Dancel2; Jodie V. Johnson2; Fabian M. Dayrit1; 1Ateneo
de Manila University, Quezon, Philippines; 2University of
Florida, Gainesville, FL
Mapping the “Known Metabolome” Using SciFinder
Scholar for More Efficient HPLC-PDA-HRMS
Dereplication of Crude Plant Extracts; Andrew Newsome;
Elizabeth Martinez; Richard van Breemen; University of
Illinois College of Pharmacy, Chicago, IL
Analysis of Red Propolis Samples by UPLC-MS; Begoña
Gimenez-Cassina; Alexandra C.H.F. Sawaya; BTPB Institute of Biology - Unicamp, Campinas, Brazil
Analysis of Bioactive Loline Alkaloids in Achnatherum
robustum and Lolium pratense by High Resolution
Mass Spectrometry; Scott Jarmusch1; Mario Figueroa1;
Brandie Ehrmann1; Tatsiana Shymanovich1; Stanley Faeth1;
Jonathan Scheerer2; Nadja Cech1; 1University of North
Carolina Greensboro, Greensboro, NC; 2College of William
and Mary, Williamsburg, VA
Rapid Screening of Herbal Extracts by Thin Layer
Chromatography-Information Dependent AcquisitionHigh Resolution Mass Spectrometry (TLC-IDA-HRMS);
Jeffrey Morré1; Jeremiah Kelley1; Nora Gray2; Amala
Soumyanath2; Jan F. Stevens1; Claudia Maier1; 1Oregon
State University, Corvallis, OR; 2Oregon Health and Science
University, Portland, OR
Imaging Metabolite Distributions in Hypericum Plants;
Zhihong Song 1, 2; Matthew C. Crispin 1; Eve Syrkin
Wurtele1; Andrew R. Korte1, 2; Young-Jin Lee1, 2; Basil J.
Nikolau1, 2; 1Iowa State University, Ames, IA; 2The Ames
Laboratory of US DOE, Ames, IA

MP 703

MP 704

MP 705

MP 706

MP 707

MP 708

MP 709

MP 710

MP 711

MP 712

Use of t-BDMS Derivatization for Enhanced Gas
Chromatography-Mass Spectrometry Analysis of
Hydroxy Terpenes in Essential Oils; Deborah Chance;
Thomas Mawhinney; University of Missouri, Columbia, MO
Determination of Vanillin in Natural Vanilla Bean
Extracts from Different Geographic Regions Using
LC/TOF; Avinash Dalmia; Daniel Pentek; Robert Packer;
George Perkins; Perkinelmer, Shelton, CT
Differentiation of Positional Carotenoid Glucoside
Isomers (Crocins) and Detection of a New Aglycon
Moiety in Crocus Sativus L; Nikolaos Stavros
Koulakiotis1, 2; Ernst Pittenauer3; Guenter Allmaier3;
Anthony Tsarbopoulos1, 4; 1The Goulandris Natural History
Museum, Kifissia, Greece; 2University of Patras, Pharmacy
Department, Patras, Greece; 3Vienna University of
Technology, Vienna, Austria; 4University of Athens Medical
School, Pharmacology, Athens, Greece
Quantitative Proteomics Analysis for the Effects of
Garlic Extracts on Neuroinflammation; Hui Zhou1, 3; Zhe
Qu1, 3; Dineo L Nkholise1, 3; Jilong Li4; Jianlin Cheng4; C.
Michael Greenlief5; Valeri V. Mossine2; Thomas Mawhinney2;
Paula N Brown7; Kevin L. Fritsche6; Dennis B. Lubahn2;
Grace Y. Sun2, 3; Zezong Gu1, 3; 1University of Missouri
School of Medicine Patholog, Columbia, MO; 2Biochemistry,
Columbia, Mo; 3Center for Translational Neuroscience,
University, Columbia, MO; 4Department of Computer Science,
Informatics Insti, Columbia, Mo; 5Chemistry, Columbia, Mo;
6
Division of Animal Sciences, Columbia, Mo; 7British Columbia
Institute of Technology, Vancouver, BC, Canada
Discovering Peptidic Natural Products by
Computational Mass Spectrometry and Genome
Mining; Hosein Mohimani1; Roland Kersten1; Wei Ting Liu1;
Mingxun Wang1; Samuel O. Purvine2; Si Wu2; Heather M.
Brewer2; Ljiljana Pasa-Tolic2; Bradley S. Moore1; Pieter C.
Dorrestein1; Pavel A. Pevzner1; 1University of California, San
Diego, La Jolla, CA; 2PNNL, Richland, WA
Identification of Bioactive Compounds in Gentiana
by UHPLC tandem QTOF Mass Spectrometry;
Wei Du; Xiaorong Ran; Tao Bo; Wei Chen; Agilent
Technologies(China) Co. Ltd., Beijing, China
Rapid Identification of Major Active Constituents in
Traditional Chinese Medicine Using UHPLC/ High
Resolution Q-TOF Mass Spectrometry and Database
Searching; Xiaorong Ran; Tao Bo; Wei Chen; Zhixu Zhang;
Agilent Technologies (China), Beijing, China
Rapid Accurate Mass Technology for Comparative
Metabolism Study of Isoimperatorin and Imperatorin
in Liver Microsomes of Five Species; Kerong Zhang1;
Xiaomei Zhuang2; Yuhuan Zhong2; Ping Du1; Jiehui Hu1;
Ting Liu1; Jingchao Lin1; Yongming Xie1; Hua Li2; 1AB
SCIEX, Beijing, China; 2Beijing Institute of Pharmacology
and Toxicology, Beijing, China
Identification and Confirmation of Ginsenosides in
Panax Extract Using a hybrid Triple Quadrupole Linear
Ion Trap System; Dandan Si; Ting Liu; Jiehui Hu; Xiaoyan
Xu; Ping Du; Yongming Xie; AB SCIEX, Shanghai, CN
Specific Drug Target Identification with Quantitative
Chemical Proteomics; Jigang Wang1; Xing Fei Tan1; Van
Sang Nguyen1; Peng Yang2; Jing Zhou1; Mingming Gao3;
Zhengjun Li4; Teck Kwang Lim1; Yingke He5; Chye Sun
Ong6; Yifei Lay1; Jianbin Zhang1; Guili Zhu5; Yu Keung
Mok1; Han-Ming Shen1; Qingsong Lin1; 1National University
of Singapore, Singapore, Singapore; 2School of Pharmacy,
University of Pittsburgh, Pittsburgh, PA; 3University of
Maryland, Rockville, MD; 4NUS Environmental Research
Institute, Singapore, Singapore; 5Duke-NUS Graduate
Medical School, Singapore, Singapore; 6Singapore
Polytechnic, Singapore, Singapore

61ST ASMS CONFERENCE ON MASS SPECTROMETRY						

PAGE 83

MONDAY
POSTERS
GENERAL
INFORMATION

MP 713

MP 714

Identification of Complex Constituents in Herba
Sarcandrae Using High Speed Accurate Mass
Technology; Guoliang Xu1; Yu Lei2; Ting Liu2; Qiyun
Zhang1; Guangbin Shang1; Xiaoyan Xu2; Ping Du2;
Yongming Xie2; Xilan Tang1; 1Jiangxi University of Traditional
Chinese Medicine, Nanchang, Jiangxi Province, China; 2AB
SCIEX Asia Pacific Application Support Center, Shanghai,
China
Development of Qualitative Method for Marker
Compounds of Bang-poong-tong-sung-san by Iontrap
Hybrid Time Of Flight (IT-TOF) Mass Spectrometer;
Unyong Kim; Han Young Eom; Joon Hyuk Suh; Sang Beom
Han; Chung Ang Univ., Seoul, South Korea

MP 722

MP 723

MP 724

Astrobiology & Atmospheric Chemistry, 715 - 720
MP 715

MP 716

MP 717

MP 718

MP 719

MP 720

Astrobiologically-Relevant Ions in the Gas Phase;
Callie Cole1; Nadine Wehres1, 2; Jennifer Reece1; Nicholas
Demarais1; Theodore Snow2, 3; Veronica Bierbaum1, 2;
1
University of Colorado at Boulder, Boulder, CO; 2Center
for Astrophysics and Space Astronomy, Boulder, CO;
3
Department of Astrophysical and Planetary Sciences,
Boulder, CO
Characterization of Heavy Ion Radiation-Induced
Changes of Lipid Biochemistry in the Liver by MALDI
Imaging Mass Spectrometry; Alexander S. Shavkunov1;
Huiling Liu1; Norelle C. Wildburger1, 2; Maureen McCarthy3,
4
; Yongjia Yu3, 4; Lauren N. Macias3, 4; Astrid D. Corbitt3, 4;
Daniel Olivares3, 4; Robert L. Ullrich3, 4; Carol L. Nilsson1,
4 1
; Department of Pharmacology and Toxicology, UTMB,
Galveston, TX; 2Department of Neuroscience and Cell
Biology, UTMB, Galveston, TX; 3Department of Radiation
Oncology, UTMB, Galveston, TX; 4UTMB Cancer Center,
Galveston, TX
Characterization of Biogenic Secondary Organic
Aerosol using Ultrahigh-Resolution FT-ICR Mass
Spectrometry; Lynn Mazzoleni; Yunzhu Zhao; Megan
Dalbec; Michigan Technological University, Houghton, MI
In situ Analysis of Mars Analog Samples Containing
Perchlorate by the MOMA Linear Ion Trap Mass
Spectrometer; Ricardo Arevalo Jr. 1; Veronica Pinnick2;
Xiang Li2; Friso van Amerom3; Ryan Danell4; William
Brinckerhoff1; Paul Mahaffy1; 1NASA Goddard Space Flight
Center, Greenbelt, MD; 2University of Maryland Baltimore
County, Baltimore, MD; 3SRI International, Inc., St.
Petersberg, FL; 4Danell Consulting, Inc., Greenville, NC
Miniature Two-Step Laser Time-of-Flight Mass
Spectrometer for in situ Planetary Missions; Xiang Li1;
Stephanie Getty2; William Brinckerhoff2; Timothy Cornish3;
Scott Ecelberger3; Melissa Floyd2; 1University of Maryland,
Baltimore County, Baltimore, MD; 2NASA Goddard Space
Flight Center, Greenbelt, MD; 3C&E Research, Inc.,
Columbia, MD
Micro-Ion Trap Mass Spectrometers for (Pre)-Biotic
Organic Compound Analysis on Comets; Friso Van
Amerom1; Ashish Chaudhary1; Timothy Short1; Patrick
Roman2; William Brinckerhoff2; Daniel Glavin2; Paul
Mahaffy2; 1SRI International, St. Petersburg, Florida; 2NASA
Goddard Space Flight Center, Greenbelt, MD

MP 725

MP 726

MP 727

MP 728

MP 729

MP 730

MP 731

MP 732

MP 733

MP 734

Polymers, 721 - 749
MP 721

The NIST Synthetic Polymer MALDI Recipes Database:
Current Status and Future Prospects; William E. Wallace;
Janiel J. Reed; Charles M. Guttman; National Institute of
Standards & Technology, Gaithersburg, MD

PAGE 84					

MP 735

In situ Characterisation of Microbicidal Agents within
Polymer-Based Surface Coatings by Liquid Extraction
Surface Analysis Mass Spectrometry; Martin R. L.
Paine1; Tran T. Hyunh2; Mike J. Manefield2; Philip J.
Barker3; Scott A. Rice2; Stephen J. Blanksby1; 1University
of Wollongong, Wollongong, Australia; 2University of
New South Wales, Sydney, Australia; 3BlueScope Steel
Research, Port Kembla, Australia
Using Ion Mobility for ‘Shape-Selective’
Characterization of Polymers; Kirsten Craven1; Julien
De Winter2; Pascal Gerbaux2; 1Waters, Manchester, UK;
2
University of Mons, Mons, Belgium
Characterization of Oligomeric Polyethylene Monoiodides by MALDI-ToF Mass Spectrometry Following
Derivatization; Roman Borisov; Nikolai Polovkov; Vladimir
Zaikin; Alexei Vinogradov; Alexei Ivaniuk; Topchiev Institute
of Petrochemical Synthesis, Moscow, Russian Federation
Mass Spectrometry and Tandem Mass Spectrometry
Analysis of Alkyl Polyglysoside (APG) Surfactants;
Ahlam Alalwiat; Chrys Wesdemiotis; The University of
Akron, Akron, U.S.A
Tandem Mass Spectrometry of Polyethers - Size and
Collision Energy Effects; Nadrah Alawani; Lydia Cool;
Chrys Wesdemiotis; University of Akron, Akron, OH
Copolyesters – Influence of End-Capping and Main
Chain Sterics on Biodegradation; Lydia Cool; Chrys
Wesdemiotis; The University of Akron, Akron, OH
Multidimensional Mass Spectrometry Studies on
Dendritic Calibrants; Aleer M. Yol1; Scott M. Grayson2;
Chrys Wesdemiotis1; 1The University of Akron, Akron, OH;
2
Tulane University, New Orleans, LA
Characterization of Poly(ε-caprolactone)-bpoly(ethylene glycol) Copolymers by Mass
Spectrometry Techniques; Marisa Carchedi1, 2; Chrys
Wesdemiotis2; Bartolo Gabriele1; Alessia Fazio1; Giovanni
Sindona1; 1University of Calabria, Rende (CS), Italy;
2
University of Akron, Akron, OH
Tandem Mass Spectrometry of Glycopolymers; Xiumin
Liu; Lydia Cool; Chrys Wesdemiotis; The University of
Akron, Akron, OH
Quantitative Analysis of Fibre Mixture by Matrix
Assisted Laser Desorption/Ionization Coupled Time of
Flight Mass Spectrometer (MALDI-TOF MS); Ssu-Hsueh
Sun; Tsung-Ming Huang; Bureau of Standards, Metrology
and Inspection, Taipei, Taiwan
Effectiveness of Tertiary Ionic Liquid Matrix in the
MALDI Analysis of PEG Polymers; Taehee Kim; Jihyeon
Lee; Jeongkwon Kim; Chungnam National University,
Daejeon, South Korea
High Throughput Characterization of Biopolyol Using
DART-MS with Ultra-Fast Polarity Switching; Christopher
Gilles1; Keiko Matsumoto2; Teruhisa Shiota3; Jun
Watanabe2; Mariko Yoshioka4; Nobuo Shiraishi 5; 1Shimadzu
Scientific Instruments,Inc., Columbia, MD; 2Shimadzu
Corporation, Kyoto, Japan; 3AMR, Inc, Tokyo, Japan; 4Kyoto
University, Kyoto, Japan; 5Shiraishi Biomass Co., Ltd.,
Kyoto, Japan
Completely Elucidating Soft Matter: Sequencing
Linear Copolymers; Martin S. Engler1; Sarah Crotty1;
Christian Pietsch1; Kerstin Scheubert1; Ulrich S. Schubert1,
2
; Sebastian Boecker1, 2; 1Friedrich Schiller University, Jena,
Germany; 2Jena Center for Soft Matter, Jena, Germany
Location of Cations Adducted to PEO-PAMAM Hybrid
Molecules: A Combined MS/MS and Ion Mobility Study;
Christophe Chendo; Aura Tintaru; Qi Wang; Ling Peng;
Laurence Charles; Aix-Marseille University, Marseille, FR

61ST ASMS CONFERENCE ON MASS SPECTROMETRY

MONDAY POSTERS

MP 736

MP 737

MP 738

MP 739

MP 740

MP 741

MP 742

MP 743

MP 744

MP 745

MP 746

MP 747

MP 748

Advantages of Mass Spectrometric Detection for
Polymers Separated by UltraPerformance Convergence
Chromatography; Oliver Burt1; Baiba Cabovska2;
Michael O’Leary2; Peter Hancock1; 1Waters Corporation,
Manchester, UK; 2Waters, Milford, MA
MALDI-TOF MS of Hyperbranched Polymers Aided
by Liquid Chromatography Separation; Jessica N.
Hoskins1; Hans R. Kricheldorf2; Steffen M. Weidner1; Jana
Falkenhagen1; 1Fed. Institute for Materials Research and
Testing, Berlin, Germany; 2Institute for Technical and
Macromolecular Chem., Hamburg, Germany
Analysis of Ethylene Oxide and Propylene Oxide
Random Copolymer by Using LC-MALDI-SpiralTOF
MS; Yoshiyuki Itoh1; Masahiro Hashimoto1; Bram van der
Meer2; Akihiko Kusai1; 1JEOL Ltd., Akishima, Japan; 2JEOL
(Europe) B.V., Nieuw-Vennep, The Netherlands
Fragmentation of Deprotonated Polyethylene Glycol;
Daniel Goebbert; Thomas Hester; The University of
Alabama, Tuscaloosa, AL
Quantitation of ppm-ppb Level Oligomeric Surfactants
for Contact Lens Wear Clinical Studies Using HR/
AM-MS and Low Resolution Chromatography; William
Nichols1; Andrew J. Hoteling2; 1Mass2Charge Consulting
LLC, Newark, NY; 2Bausch+Lomb, Rochester, NY
Evaluating the Use of Ion Mobility-Mass Spectrometry
for Polymer End Group Characterization Using
Polydimethyl Siloxane as a Model; Andrew J. Hoteling1;
Eleanor Riches2; 1Bausch + Lomb, Rochester, NY; 2Waters
Corporation, Manchester, UK
Characterization of Polymer Extracts by Gas
Chromatography–High Resolution Time-Of-Flight
Mass Spectrometry with Electron Impact and Chemical
Ionization Strategies; Nick Hall; David Alonso; Joe Binkley;
Leco Corporation, St. Joseph, MI
MALDI-ToF MS Analysis for Confirmation of Polymer
End Groups; Brittany Myers; Boyu Zhang; Scott M.
Grayson; Tulane University, New Orleans, LA
Versatile Dendritic Calibrants for the Improved
Accuracy of Mass Determination for High Molecular
Weight Analytes; Scott M. Grayson; Joseph Giesen;
Brittany Myers; Tulane University, New Orleans, LA
An Integrated Systems Approach to Identifying
Extractables From Single Use Materials: “Closing
the Gap on Total Organic Content (TOC).”; Catherine
E Petersen; Sarah Robinson; Trent Volz; Ray Colton;
Validation Resources, Bend, OR
End-Group Cleavage during MALDI of ATRP Made
Polystyrene: The Problem is in the Solution; Laurence
Charles; Aura Tintaru; Christophe Chendo; Trang Phan;
Marion Rollet; Laurent Giordano; Stéphane Viel; Didier
Gigmes; Aix-Marseille University, Marseille Cedex 20,
France
Identification of Defective Structures of PAMAM
Dendrimer Using Various Separation Methods Coupled
with Mass Spectrometry: LC-MS, CE-MS and TLCMS; Emma-Dune Leriche1; Marie Hubert-Roux1; Martin
Grossel2; Catherine Lange1; Carlos Afonso1; Corinne
Loutelier-Bourhis1; 1Normandie Univ UMR 6014, FR 3038;
Univ Rouen; CNRS, Mont-St-Aignan, France; 2University of
Southampton, School of chemistry, Southampton, UK
Identification and Quantitation of Plastics Additives
in Medicine and Containers by HR LCMS and Triple
Quadrupole GCMS; Ekong Bassey; Kate Comstock;
Thermofisher Scientific, San Jose, CA

MP 749

Characterization of Trace Organic Impurities in Purified
Terephthalic Acid (PTA) by Using UPLC Q-TOF MS for
Process Optimization; Yuhong Zhang1; Chuan Wang1;
Zhenlei Peng1; Yidan Guo1; Kejun Qian2; Xiaomei Huang2;
Peter Lee3; 1SINOPEC SRIPT, Shanghai, China; 2Waters
Technologies (Shanghai) Limited, Shanghai, China; 3Waters
Cooperation, Milford, MA

61ST ASMS CONFERENCE ON MASS SPECTROMETRY						

PAGE 85

GENERAL
INFORMATION
TUESDAY
POSTERS

7:30-8:00 am............................................... Set up all Tuesday posters
10:30 am-1:00 pm................................Odd-numbered posters present
12:00-2:30 pm.................................... Even-numbered posters present
7:30-8:00 pm............................................ Remove all Tuesday posters
Ion Activation/Dissociation.........................................................001-020
Ion/Molecule, Ion/Ion, Ion/Electron Interactions........................021-048
Photoionization: Instrumentation & Applications.......................049-053
Instrumentation: New Developments in Ionization
and Sampling....................................................................054-087
Instrumentation: New Concepts................................................088-109
Peptides: Fragmentation Mechanisms...................................... 110-123
Peptides: Ion Activation/Dissociation Strategies.......................124-128
Peptides: Quantitative Analysis I...............................................129-163
Proteins: Conformation Analysis...............................................164-172
Protein Covalent Labeling.........................................................173-193
Biomolecular Structure..............................................................194-205
Intact Proteins: PTM Discovery.................................................206-212
Intact Proteins: Quantitative Analysis........................................213-217
Intact Proteins: Sequence Analysis...........................................218-224
Protein Therapeutics: Structural Characterization.....................225-238
Informatics: Intact Proteins........................................................239-244

TP 001

TP 002

TP 003

TP 004

TP 005

TP 006

TP 007

TP 008

TP 009

Ion Activation/Dissociation, 001 – 020
Investigation into UV Photon Induced Fragmentation in
a RF confined Ion Guide using a Vacuum UV Ionisation
Lamp; Martin Green; Keith Richardson; Jeff Brown; Paul
Murray, Waters Corporation, Manchester, United Kingdom
UV Photodissociation within an Axially Illuminated
Stacked Ring Ion Guide of an Ion Mobility Enabled
Q-ToF; Jeff Brown 1; Mike Morris1; Kevin Giles1; Richard
Chapman1; Paul Murray1; Emmy Hoyes1; Christopher
Jones1; Jakub Ujma2; Bruno Bellina3; Isabelle Compagnon3;
Perdita Barran2, 1Waters Corporation, Manchester , UK;
2
The University of Edinburgh, Edinburgh, UK; 3CNRS et
Université Lyon, Lyon, France
Hybrid UVPD Activation of N- and C-Terminal Fixed
Charge Peptides; Dustin Holden; Jennifer Brodbelt;
University of Texas Chemistry, Austin, TX
Fragmentation of Fluorescence Dye Labels Activated
by Collisions or Photons; Jonathan Peters; Claus
Gernert; Martin Clemen; Tassilo Muskat; Jürgen
Grotemeyer; Inst. f. Phys. Chemie, Christian-Albrechts-Uni,
Kiel, Germany
Sequential Losses of HONO, CO and HCN from
Deprotonated ortho-Nitrobenzenesulfonylglycine
(Ns-Gly) Upon ESI(–)MS/MS; Robert L. White; Tara E.
Tovstiga; Elizabeth A.L. Gillis; J. Stuart Grossert; Dalhousie
University, Department of Chemistry, Halifax, Canada
Diastereomeric Quantification of O-diglycosyl
Flavonoids by a Complex-Free Kinetic Method Using
ESI/QToF Mass Spectrometry; Yong-Ill Lee; Kuangcai
Chen; Jae-Min Lim; Changwon National University,
Changwon, Korea
Characterization of Temperature-Dependent Peptide
Bond Cleavage Using Low- and High-Mass Quantitation
Signals from Amine-Reactive N-Acetyl Dipeptide Tags;
Jongcheol Seo; Hye-Joo Yoon; Seung Koo Shin; Postech,
Pohang, South Korea
Fragmentation of Trans-Membrane Helices in Gaseous
Protein Ions; Owen Skinner; Adam Catherman; Kenneth
Durbin; Bryan Early; Paul Thomas; Neil Kelleher;
Northwestern University, Evanston, IL
Metastable Atom-Activated Dissociation of
Phosphocoline Lipids in Protonated, Sodiated, and
Potassiated Forms; William D. Hoffmann1; Robert E.
Deimler1; Madlen Sander2; Glen P. Jackson1; 1West Virginia

PAGE 86					

Informatics: Systems Biology and Large-Scale Analyses.........245-254
Biomarker Discovery: Proteins..................................................255-275
Neurodegenerative, Cardiovascular and Infectious Disease....276-297
New Technologies in Biomarker Discovery...............................298-305
Proteomics: Plasma and Tissue................................................306-341
Epigenetic Modifications/Histones.............................................342-356
Metabolomics: General.............................................................357-382
Metabolomics: Untargeted Metabolite Profiling Applications.....383-419
Drug Metabolism: Quantitative Analysis....................................420-451
Small Molecules: Quantitative Analysis II,.................................452-477
Lipids: Quantitative Analysis......................................................478-497
Informatics: Quantification/Validation........................................498-528
Toxicology..................................................................................529-556
Diagnostic Clinical Chemistry: Small Molecules I......................557-577
Environmental Analysis: Pharmaceuticals and Pesticides........578-607
Elemental Analysis....................................................................608-618
Ion Mobility Applications............................................................619-661
Ambient Ionization: Applications I..............................................662-690
Carbohydrates I.........................................................................691-714
Glycoproteins I..........................................................................715-737
Food Safety...............................................................................738-772

TP 010

TP 011

TP 012

TP 013

TP 014

TP 015

TP 016

TP 017

TP 018

TP 019

University, Morgantown, WV; 2Leipzig University, Leipzig,
Germany
Focused Proteomics Through Selective Modification of
Tryptophan or Arginine Residues; Dustin Klein; Sylvester
Greer; Jennifer Brodbelt; University of Texas, Austin, TX
Fragmentation of Protonated Nitromethane; Thomas
Hester; Daniel Goebbert; The University of Alabama,
Tuscaloosa, AL
Comparison between Surface-Induced Dissociation
(SID) and Collision-Induced Dissociation (CID) of IonMobility (IM)-Separated Detergent Clusters; Yun Zhang;
Mowei Zhou; Xin Ma; Vicki H. Wysocki; The Ohio State
University, Columbus, OH
Optimization of Surface Induced Dissociation (SID)
Effect in Intermediate Vacuum Ion Guides; Zoltán
Takáts2; Tamás Karancsi1; Dániel Szalay1; Andor Rozsnyai1;
1
Medimass Ltd., Budapest, Hungary; 2Imperial College
London, London, Egyesült Királyság
Dipolar Direct Current Driven Collision Induced
Dissociation in Digital Ion Trap; Liang Wang; Fuxing Xu;
Chuan-Fan Ding; Fudan University, Shanghai, China
Hydration Energies of First–Row Transition Metal
Dications Determined by Collision Induced Dissociation
and Density Functional Theory; Rebecca Thomas;
Theresa Hofstetter; Peter Armentrout; University of Utah,
Salt Lake City, UT
Gas-Phase Fragmentation of Cationic Metal Adducts of
Oxalate Salts; Robert Hale; Carl Weisbecker; Chang-Ching
Chan; Athula Attygalle; Stevens Institute of Technology,
Hoboken, NJ
Structures and Activation Energies for Glycosidic Bond
Cleavage of Protonated Nucleosides: A Synergy of
Theory and Threshold Collision-Induced Dissociation
Experiments; Mary T. Rodgers; Ranran Wu; Wayne State
University, Detroit, MI
Nazarov Cyclization and Six-Membered Cyclization of
Chalcones Catalyzed by the Naked Silver Cation in Gas
Phase; Hezhi Sun; Yunfeng Chai; Lin Wang; Yuanjiang
Pan; Zhejiang University, Hangzhou, China
Second Generation Electron Transfer Dissociation
(ETD) on a Novel Hybrid Instrument with Improved
Functionality, Increased Speed, and Robustness of
Data; Christopher Mullen1; Lee Earley1; Jean-Jacques
Dunyach1; John E.P. Syka1; Philip Daniel Compton2; Jeffrey

61ST ASMS CONFERENCE ON MASS SPECTROMETRY

TUESDAY POSTERS

TP 020

Shabanowitz3; Donald F. Hunt3; 1Thermo Fisher Scientific,
San Jose, CA; 2Northwestern University, Evanston, IL;
3
University of Virginia, Charlottesville, VA
Comparison of MALDI-ISD and High-Energy CID Using
a Spiral-Trajectory Time-Of-Flight Mass Spectrometer;
Masaaki Ubukata1; John Dane1; Robert B. Cody1; Ayumi
Kubo2; 1JEOL USA, Inc., Peabody, MA; 2JEOL Ltd., Tokyo,
Japan

Ion/Molecule, Ion/Ion, Ion/Electron Interactions, 021 - 048
TP 021

TP 022

TP 023

TP 024

TP 025

TP 026

TP 027

TP 028

TP 029

TP 030

TP 031

TP 032

TP 033

Distinguishing Amorphous and Crystalline Ices by
Ultra-Low Energy Collisions of Reactive Ions; Radha
Gobinda Bhuin; Soumabha Bag; T. Pradeep; Indian Institute
of Technology, Madras, Chennai, India
Experimental Evidence and Characterization of
Cobalt(I) Complexes Relevant in Regioselective DielsAlder Reactions. A Gas Phase Study; Lukas Fiebig1;
Julian Kuttner2; Martin C. Schwarzer2; Gerhard Hilt2; Gernot
Frenking2; Hans-Günther Schmalz1; Mathias Schaefer
1 1
; University Cologne, Department of Chemistry, Koeln,
Germany; 2Philipps University, Department of Chemistry,
Marburg, Germany
Computational Studies of Ion-neutral Reactions of
Astrochemical Relevance: Formation of Hydrogen
Peroxide and Amino Acetonitrile; Zhibo Yang; University
of Oklahoma, Norman, OK
Chiral Selectivity of Copper Di-imine Catalysts in
the Gas Phase; Mark Davis; Scott Gronert; Virginia
Commonwealth University, Richmond, VA
Synthesis, Characterization, and Reactivity of Gold
Carbenes in the Gas Phase; Christopher Swift; Scott
Gronert; Virginia Commonwealth University, Richmond, VA
The Flipper: New MS Technology for the Generation
of Highly Charged Anionic Reagents for Gas-Phase
Purification; Rebeca Pinhancos; Catherine E. Vincent;
Michael S Westphall; Joshua J. Coon; University of
Wisconsin, Madison, WI
Electrochemical-Assistance for Electron Transfer
Dissociation Ion Mobility MS of Peptides and Proteins;
Jonathan P. Williams; Christopher Hughes; Jeffery Brown;
Waters, Manchester, UK
The Use of Reagent Clusters in Ion/ion Reactions for
Multiple Gas-phase Covalent Modifications of Peptides
and Proteins; Boone Prentice; John Stutzman; Scott
McLuckey; Purdue University, West Lafayette, IN
Characterization of Gas-Phase Esterification of Various
Doubly Deprotonated Analytes; Joshua D. Gilbert; Boone
M. Prentice; John R. Stutzman; Scott A. McLuckey; Purdue
University, West Lafayette, IN
Lithium Cation Basicity: Revisiting the High Basicity
Range by Experiment and Theory; Charly Mayeux1;
Peeter Burk1; Jean-François Gal2; Tõiv Haljasorg1; Ivari
Kaljurand1; Ivo Leito1; 1University of Tartu, Tartu, Estonia;
2
University of Nice-Sophia Antipolis(UMR CNRS 7272),
Nice, France
A Custom Mass Spectrometer to Probe Ion-Ion Reaction
Products Through Infrared Spectroscopy; Nathan Roehr;
Corey Stedwell; Nick Polfer; Kerim Gulyuz; University of
Florida, Gainesville, FL
Gas-Phase Synthesis of Copper Carbene Complexes
and Evaluation of Their Structure and Reactivity; Jamal
Aldajaei; Virginia Commonwealth Uni., Richmond, VA
Electron Detachment Dissociation of Anion-Adducted
Peptides; Tao Jiang; Kristina Hakansson; University of
Michigan, Ann Arbor, MI

TP 034

TP 035

TP 036

TP 037

TP 038

TP 039

TP 040

TP 041

TP 042

TP 043

TP 044

TP 045

TP 046

TP 047

TP 048

Gas-Phase Chemistry of Polycyclic Aromatic
Hydrocarbon Cations and Their Nitrogen Containing
Analogues; Nicholas Demarais; Theodore Snow; Veronica
Bierbaum; U of Colorado, Boulder, CO
Gas-Phase Organic Reactions of the Atomic Oxygen
Radical Cation; Charles Nichols1; Zhibo Yang2; Veronica
Bierbaum1; 1University of Colorado, Boulder, CO; 2University
of Oklahoma, Norman, OK
Gas-Phase Studies of Radical Migration within
Tryptophan-Containing Peptides; Andrii Piatkivskyi; Victor
Ryzhov; Northern Illinois University, Dekalb, IL
A Bracketing Method for Proton Affinity Measurements
for Pyridine Radicals and Biradicals; Guannan Li;
Vanessa Gallardo; John Nash; Anyin Li; Hilkka Kenttämaa;
Purdue University, West Lafayette, IN
A Comparison of the Reactions of N-Methyl-3dehydropyridinium Cation with Adenine, Cytosine,
Thymine and Uracil in Gas Phase and Aqueous
Solution; Ashley Wittrig; Hilkka Kenttamaa; Purdue
University, West Lafayette, IN
Steric Effects in the Characterization of Proton Affinities
of N,N’-Diamidocarbenes; Mu Chen2; Christopher
Bielawski1; Jeehiun K. Lee2; 1The University of Texas at
Austin, Austin, TX; 2Rutgers University-New BrunswickChemistry, Piscataway, NJ
Formation of Hydroxylmethyl Radicals and Their
Reactions with Cysteinyl Peptides in NanoESI Plume;
Craig Stinson; Yu Xia; Purdue University, West Lafayette, IN
Characterization of Gas-Phase Ion-Molecule Reagent
Complexes In Support of Trace Explosives Detection
Using API-MS; Kerin Gregory; Alla Ostrinskaya; Roderick
Kunz; MIT Lincoln Laboratory, Lexington, MA
Ion/Ion Reactions to Extend Peptides in the Gas Phase:
A Route to Gas Phase Peptide Synthesis; William M.
McGee; Scott A. McLuckey; Purdue University, West
Lafayette, IN
Probing the Reactivity and Radical Nature of Oxidized
Transition Metal-Thiolate Complexes by Mass
Spectrometry; Mei Lu1; Larry Campbell2; Rajat Chauhan3;
Craig Grapperhaus3; Hao Chen1; 1Ohio University, Athens,
OH; 2AB Sciex, Concord, Ontario; 3University of Louisville,
Louisville, Kentucky
High-Temperature Mass Spectrometric Study of the
System CsI-CeI3; Dmitry Ivanov; Anatoly Dunaev; Dmitry
Sergeev; Lev Kudin; Ivanovo State University of Chemistry
and Technolo, Ivanovo, Russia
Analysis Method for Competitive CAD-ETD Gas Phase
Reaction with Kinetic Energy Measurement of Ionic and
Neutral Fragments; Masataka Ohkubo 1; Shigetomo Shiki1;
Masahiro Ukibe1; Shigeo Tomita2; Shigeo Hayakawa3;
1
AIST, RIIF, Tsukuba, Japan; 2University of Tsukuba,
Tsukuba, JP; 3Osaka Prefecture University, Osaka, JP
Oxidation of CO by Molecular Oxygen Catalyzed with
Y3O6‒ Cluster Anions; Yan-Xia Zhao; Zi-Yu Li; Xun-Lei
Ding; Sheng-Gui He; State Key Laboratory for Structural
Chemistry of U, Beijing, China
Etoricoxib as a Tool for the Detection of Low Levels of
Oxygen in Mass Analyzers; Freneil Jariwala; John Hibbs;
Athula Attygalle; Stevens Institute of Technology, Hoboken,
NJ
Energy-Resolved Collision-Induced Dissociation
Studies of 1,10-Phenanthroline Complexes of the
Late First-Row Divalent Transition Metal Cations:
Determination of the Binding Energies; Holliness Nose;
Mary Rodgers; Wayne State University, Detroit, MI

61ST ASMS CONFERENCE ON MASS SPECTROMETRY						

PAGE 87

GENERAL
INFORMATION
TUESDAY
POSTERS

Photoionization: Instrumentation & Applications, 049 – 053
TP 049

TP 050

TP 051

TP 052

TP 053

Capture of Tunneling Electrons and Dissociation of
Organic Molecules Initiated by Unpaired Electrons;
Hongying Zhong; Lulu Huang; Central China Normal
University, Wuhan, China
Mass Spectrometry Analysis of Volatile NitroSubstituted Explosives by Laser Ionization under
Ambient Conditions; Evgeny Kukaev1, 4; Alexey
Kononikhin1, 2; Igor Popov1, 4; Konstantin Nagornov2, 3;
Eugene Nikolaev1, 2; 1Emanuel Institute of Biochemical
Physics, Moscow, Russia; 2Institute for Energy Problems of
Chemical Physics, Moscow, Russia; 3Inst of Radio-engin.,
Electronics and Automation, Moscow, Russia; 4Moscow
Institute of Physics and Technology, Moscow, Russia
Photoionization Mass Spectrometry of Thermolabile
Biomolecules at the French National Synchrotron
Facility SOLEIL; David Touboul1; Marie Méjean1; François
Gaie-Levrel2; Gustavo Garcia Macias3; Laurent Nahon3;
Lionel Poisson4; Martin Schwell5; Majdi Hochlaf6; Alexandre
Giuliani7; Alain Brunelle1; 1CNRS, Institut de Chimie des
Substances Naturelles, Gif-Sur-Yvette, France; 2National
Metrology Institute and Testing, Paris, France; 3Synchrotron
SOLEIL, DESIRS beamline, Gif-sur-Yvette, France;
4
Laboratoire Francis PERRIN, Gif-sur-Yvette, France; 5LISA
UMR 7583, Crétail, France; 6Université Paris-Est, MSME,
Maren-la-Vallée, France; 7Synchrotron SOLEIL, DISCO
beamline, Gif-sur-Yvette, France
The Use of Isoprene as a New Dopant in Negative Ion
Atmospheric Pressure Photo Ionization (NI-APPI) Mass
Spectrometry; Faezeh Dousty; Rob O’Brien; University of
British Columbia, Okanagan Campus, Kelowna, Canada
Online Quantification of Tobacco by Soft Photo
Ionization Time of Flight Mass Spectrometry; Matthias
Bente-Von Frowein; Andreas Walte; Thomas Gröger;
Mohammad Reza Saraji-Bozorgzad; Photonion, Schwerin,
Germany

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Instrumentation: New Developments in
Ionization and Sampling, 054 – 087
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Study of an ESI Source Which Uses a Vacuum Insulated
Tube to Increase Ionization Efficiency and Operates at
Subambient Pressure; Steve Schachterle; Zicheng Yang;
Maurizio Splendore; Stephen Zanon; Roy Moeller; Felician
Muntean; Bruker Daltonics, Fremont, CA
Evaluation of Amine-Containing Polymer Brushes
and Polymer Thin Films for Biomolecular Mixture
Fractionation Prior to MALDI MS; Stephanie Eastwood;
Bojan Mitrovic; Venney Wong; Joshua Pogue; Colleen Scott;
Gary Kinsel; Southern Illinois University, Carbondale, IL
Flow Characteristics of a Laminar Flow Interface for
LC-MS/MS; Serguei Savtchenko; Charles Joliffe; Heather
Gamble; Lisa M. Cousins; Hui Quao; IONICS Mass
Spectrometry Group, Inc., Bolton, Canada
Coupling High Performance Ion Mobility Spectrometers
to Common Mass Spectrometers; Robert Jackson; Mark
Osgood; Eugenie Hainsworth; Jianglin Wu; Ching Wu;
Excellims Corporation, Acton, MA
Static Electricity and Novel Spray Ionization Methods;
Abdil Ozdemir2; Jung-Lee Lin1; Kent J. Gillig1; Chung-Hsuan
Chen1; 1Genomics Research Center, Academia Sinica,,
Taipei, Taiwan; 2Sakarya University, Adapazari, Turkey
Velocity Map Imaging Spectrometer: An Off-the-Shelf
System for Gas-Phase Chemistry and Laser Physics
Experiments; Orla Kelly1, 2; Panos Kapetanopoulos1;
Michael NR Ashfold2; 1Photek Ltd, St Leonards On Sea, UK;
2
School of Chemistry, University of Bristol, Bristol, UK

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An UV-AP-MALDI Source and Liquid UV-MALDI Samples
Enable the Formation of Multiply Charged Peptides and
Proteins and Their High-Sensitivity Analysis; Rainer
Cramer1; Alex Pirkl2; Franz Hillenkamp2; Klaus Dreisewerd2;
1
University of Reading, Reading, UK; 2University of
Muenster, Muenster, Germany
Novel Soft Electron Ionisation for Mass Spectrometers;
Nick Bukowski1; Pierre Schanen2; Gerhard Horner2;
1
ALMSCO International, Llantrisant, UK; 2five technologies
GmbH, Munich, Germany
Solvent Assisted Inlet Ionization (SAII): Perspectives on
Source Design, Application, and Ionization Mechanism;
Vincent S. Pagnotti; Sarah J. Saylor; Shubhashis
Chakrabarty; Charles N. McEwen; University of the
Sciences, Philadelphia, PA
Enhancing Ionization Efficiency in ESI by a Novel
Nebulizer Design; Anneli Kruve; Ivo Leito; Rünno Lõhmus;
Asko Laaniste; Hanno Evard; Kristo Kleemann; Jaanus
Liigand; Vahur Toss; Koit Herodes; Ants Lõhmus; University
of Tartu, Tartu, Estonia
Optimization of Surface Acoustic Wave Nebulizer
Designs for Proteomics; Scott Heron1, 2; J. Scott
Edgar3; Yue Huang1; Young Ah Goo1, 2; Michael Wilson1,
2
; Sung Hwan Yoon1, 2; David R. Goodlett1, 2; 1University
of Washington, Seattle, WA; 2University of Maryland,
Baltimore, MD; 3Deurion LLC, Seattle, WA
A Closer Look at the Sensitivity Enhancement
Observed with Capillary and Nanoflow UPLC for Both
Small and Large Molecules; James Murphy; Jay Johnson;
Paul Rainville; Waters Corporation, Milford, MA
Nanostructure-Initiator Mass Spectrometry: Practical
Insights, Fundamental Implications, and Emerging
Applications; Jay Forsythe1, 2; Joshua Broussard3; Jenifer
Lawrie4; Michal Kliman1, 2; Yang Jiao5; Sharon Weiss4, 5;
Donna Webb3, 6; John McLean1, 2; 1Dept. of Chemistry and
VICB, Vanderbilt Univ., Nashville, TN; 2VIIBRE, Vanderbilt
Univ., Nashville, TN; 3Dept. of Biological Sciences,
Vanderbilt Univ., Nashville, TN; 4IGP in Materials Science,
Vanderbilt Univ., Nashville, TN; 5Dept. of EECS, Vanderbilt
Univ., Nashville, TN; 6Dept. of Cancer Biology, Vanderbilt
Univ., Nashville, TN
Development of a Soft Ionization Discharge Source for
Gas Chromatography Used with a High Resolution Time
of Flight Mass Spectrometer; Lloyd Allen1; Alexander
Kolosov2; Viatcheslav Artaev1; Anatoly Verenchikov2; 1LECO
Corp., Saint Joseph, MI; 2MSC-GC, Bar, Montenegro
A Digitized Workflow for Static Nanospray Mass
Spectrometry: Combining High Throughput, Efficiency
and Ease of Use; Gary Valaskovic; New Objective, Inc.,
Woburn, MA
An Elemental Ion Source for LC-MS: Halogen
Detection; Haopeng Wang1; Kaveh Kahen2; Ninghang
Lin1; Kaveh Jorabchi1; 1Georgetown Univ., Washington, DC;
2
PerkinElmer Inc., Woodbridge, Canda
Internal and External Ionization in a Mobile FTICRMS; Clotilde Le Vot1; Essyllt Louarn1; Helene Mestdagh1;
Michel Heninger1; Pierre Boissel2; Gérard Mauclaire2;
Joel Lemaire1; 1LCP CNRS - Université Paris Sud, Orsay,
France; 2AlyXan, Orsay, France
Online High-Capacity Capillary Isoelectric-Point
Fractionation Increases the Proteome Coverage
of Human Cell Line in Shotgun LC-MS Proteomics
Analysis; Mohammad Pirmoradian Najafabadi; Konstantin
Chingin; Juan Astorga-Wells; Harshavardhan Budamgunta;
Roman Zubarev; Karolinska Institute, Solna, Sweden

61ST ASMS CONFERENCE ON MASS SPECTROMETRY

TUESDAY POSTERS

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SmartAGC: Precursor Mass and Charge Dependent
Automatic Gain Control Improves Efficiency of Protein
Identification; Stefan K Maier1, 2; Hannes Hahne1; Fiona
Pachl1; Bernhard Kuster1; 1Technische Universitaet
Muenchen, Freising, Germany; 2Helmholtz Zentrum
Muenchen, Neuherberg, Germany
Analysis of Fuels by Wooden Tip Electrospray
Ionization-QToF-MS; Whitney Smith; Jan Sunner; Univ. of
Oklahoma, Norman, OK
Understanding the Effects of the Earth’s Magnetic
Field on Mobile Mass Spectrometry: Simulation,
Experimentation and Solutions; Ryan J. Bell5; Nicholas
G. Davey1, 5; Morten Martinsen2, 5; Christian Collin-Hansen3;
R. Timothy Short4; Erik T. Krogh1, 5; Christopher G. Gill 1,
5 1
; University of Victoria, Victoria, BC, Canada; 2NTNU,
Trondheim, Norway; 3Statoil ASA, Trondheim, Norway; 4SRI
International, St. Petersburg, FL; 5AERL, Vancouver Island
University, Nanaimo, BC, Canada
Improvements to Understanding and Implementation
of Raster Laser-Induced Acoustic Desorption for Mass
Spectrometric Analysis of Petroleum; Alex Dow; Purdue
University, West Lafayette, IN
Laser LESA: Fully Automated Laser Ablation Sample
Transfer to Solution for NanoESI Mass Spectrometry;
Matthias Lorenz; Olga S. Ovchinnikova; Gary J. Van Berkel;
Oak Ridge National Laboratory, Oak Ridge, TN
Improved Identification of Low Abundance Precursors
by Applying an Injection Waveform Utilizing Multiple
Frequency Notches; Brian K. Erickson; Graeme McAlister;
Ramin Rad; Wilhelm Haas; Steven P. Gygi; Harvard
Medical School, Boston, MA
Fabrication of Dense Polymer Nozzle Array on
Microstructured Fibers for Multi-Electrospray Ionization;
Yueqiao Fu1; Graham Gibson1; Richard Oleschuk1; Tom
Covey2; Bradley Schneider2; 1Queen’s University, Kingston,
ON, Canada; 2AB Sciex, Concord, ON, Canada
Direct Detection of Nonvolatile Compounds Using
Synchronized Discharge Ionization with Handheld
Mass Spectrometer; Xiao Wang; Tsung-Chi Chen; Zheng
Ouyang; Purdue University, West Lafayette, IN
Quantitative Ambient Analysis Using Simple Extraction
Spray; Yue Ren; Jiangjiang Liu; Linfan Li; Morgan N.
McLuckey; Zheng Ouyang; Biomedical Engineering, Purdue
University, West Lafayette, IN
Miniature Condensed Phase Membrane Introduction
Mass Spectrometry (CP-MIMS) Probes for the Direct
Measurement of Pharmaceuticals and Contaminants
in Complex Samples; Kyle D. Duncan1, 2; Erik T. Krogh1, 2;
Christopher G. Gill 1, 2; 1University of Victoria, Victoria, BC,
Canada; 2AERL, Vancouver Island University, Nanaimo,
BC, Canada
Low Flow Characterization of a Novel Multi-Channeled
Nanoelectrospray Emitter and Pneumatic Flow
Focusing Interface; Lili Mats1; David Simon1; Hui Qiao2;
Frenny Ruparelia2; Richard Oleschuk1; Lisa M. Cousins 2;
1
Queens University, Kingston, ON, Canada; 2IONICS Mass
Spectrometry, Bolton, ON, Canada
Bringing Mass Spectrometry to the Production
Floor: Separating Samples without the Need for Gas
Chromatography; Warren Mino; Michael Spencer; Lorenz
Gardner; Abrar Riaz; James Wylde; David Rafferty; 1st
Detect, Houston, TX
Use of Stokes Number for Ion Movement in Gas with
DC and RF Electric Fields: Theory, Simulation, and
Experiment; Nicolay Gall1, 2; Alexander Berdnikov2; Mikhail
Lapushkin1; Natalia Fomina1; Sergey Masukevich2; 1Ioffe
Physico-technical institute of Russian Acade, St.Petersburg,

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Russia; 2Institute for Analytical Instrumentation of RAS, R,
St.Petersburg, Russia
Plasma Induced Secondary Emission Ionization
(PISI) Source for Atmospheric Pressure Ion Mobility
Spectrometry; Prabha Dwivedi; Joel Keelor; Facundo
Fernandez; Georgia Inst. of Technology, Atlanta, GA
Construction of an Interventional Mass Spectrometer
for Intrasurgical Tissue Identification; Cristina GuallarHoyas1; Laura Muirhead1; Lajos Gödörházy2; Dániel
Szalay2; Tamás Krancsi2; Steven Pringle3; Mike Morris3;
Zoltán Takáts1; 1Imperial Collegue, London, UK; 2Medimass,
Budapest, Hungary; 3Waters Corporation, Manchester, UK
Development of Laser Ablation and Droplet Capture
(LADC) for in vivo Mass Spectrometry; Benoit Fatou;
Isabelle Fournier; Michael Ziskind; Maxence Wisztorski;
Cristian Focsa; Michel Salzet; University Lille 1, Villeneuve
D’ascq, France
Instrumentation: New Concepts, 088 – 109

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Screening of Illicit Drugs in Urine by Using a Portable
Mass Spectrometer; Masuyuki Sugiyama1; Shun Kumano1;
Masuyoshi Yamada1; Hidetoshi Morokuma2; Kazushige
Nishimura1; Yuichiro Hashimoto1; Hiroyuki Inoue3; 1Hitachi,
Ltd., Tokyo, Japan; 2Hitachi High-Technologies Corp.,
Hitachinaka, Japan; 3National Research Institute of Police
Science, Kashiwa, Japan
Cold Electron Ionization Source for a Portable Ion
Trap Mass Spectrometer; Seung Yong Kim; Mo Yang;
Hyun Sik Kim; Korea Basic Science Institute, Ochang-Eup
Cheongwon-Gun, South Korea
Optimizing the Performance of a Miniaturized Linear
Ion Trap: Adjusting RF and SWIFT Auxiliary Waveform
Parameters; Friso H.W. Van Amerom1; Veronica Pinnick2;
Xiang Li2; Ricardo Arevalo2; Rayn Danell3; Paul Mahaffy2;
Will Brinckerhoff2; 1SRI International, St Petersburg, FL;
2
Goddard Space Flight Center, Greenbelt, MD; 3Danell
Consulting Inc., Winterville, NC
Design of Portable Mass Spectrometers with Handheld
Probes: An Aspect of Ion Introduction and Pumping
System; Tsung-Chi Chen1; Chien-Hsun Chen1; R. Graham
Cooks1; Robert Kline-Schoder2; Paul Sorensen2; Zheng
Ouyang1; 1Purdue University, West Lafayette, IN; 2Creare
Inc., Hanover, NH
Development of Portable Mass Spectrometer Coupled
with Probe Heating Method for Illicit Drug Screening;
Shun Kumano1; Masuyuki Sugiyama1; Masuyoshi Yamada1;
Kazushige Nishimura1; Hidetoshi Morokuma2; Hiroyuki
Inoue3; Yuichiro Hashimoto1; 1Hitachi, Ltd., Kokubunji-Shi,
Japan; 2Hitachi High-Technologies, Hitachinaka, Japan;
3
National Research Institute of Police Science, Kashiwa,
Japan
Predictive Automatic Gain Control on a New
Quadrupole Mass Filter-Orbitrap-Linear Ion Trap
Platform; Philip M Remes; Justin Blethrow; Vlad
Zabrouskov; Michael Senko; Thermo Fisher Scientific, San
Jose, CA
Implementing UV and Visible Photodissociation in
an Q-Exactive Mass Spectrometer; Marion Girod1, 2;
Quentin Enjalbert1; Jérémy Jeudy1; Rodolphe Antoine1, 2;
Jerome Lemoine1; Philippe Dugourd1, 2; 1Université Lyon 1,
Villeurbanne, France; 2CNRS, Villeurbanne, France
Advances in Quantitative High Throughput Proteomics
Using Data-Independent Scanning Methods; Enrique
Calvo; Fernando García-Marqués; Juan Carlos Silla; Jose
Antonio Enriquez; Adela Guaras; Estefanía Nuñez; Marta
Loureiro-López; Juan Antonio López del Olmo; Jesús
Vázquez; CNIC, Madrid, Spain

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GENERAL
INFORMATION
TUESDAY
POSTERS

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Harnessing Q Exactive Multiplexing Capabilities
for Improvements in Peptide Quantitation and
Identification; Jolene K. Diedrich1; Gregory A. Barding2;
Xuemei Han1; Vlad Zabrouskov3; Michael W. Senko3; John
R. Yates III1; 1The Scripps Research Institute, La Jolla, CA;
2
University of California, Riverside, CA; 3ThermoFisher
Scientific, San Jose, CA
Design and Characterization of a Novel Hybrid-field Ion
Guide as part of a Time-of-Flight Mass Spectrometry
Platform; Alexander Lekkas; Athanasios Zacharos;
Diamantis Kounadis; Ioannis Orfanopoulos; Dimitris
Papanastasiou; Emmanuel Raptakis; Fasmatech, Athens,
Greece
Duty Cycle-Based Cross Section Measurement of
Large Singly Charged Proteins; Gregory Brabeck1; Vivek
Jayaram2; Rachit Singh2; Peter T. A. Reilly1; 1Washington
State University, Pullman, WA; 2Pullman High School,
Pullman, WA
Multiplexed Analysis of Steroid Hormones in Human
Serum Using Novel Microflow Tile Technology and
LC-MS/MS; Carolyn Broccardo1; Kevin Schauer1; Wendy
Kohrt2; Robert Schwartz2; James Murphy3; Jessica Prenni1;
1
Colorado State University, Ft Collins, CO; 2University of
Colorado Anschutz Medical Campus, Aurora, CO; 3Waters
Corporation, Milford, MA
State-of-the-Art Multidimensional HPLC+GC-MS
System: Innovations in the Operational Principles and
Applications; Nieves Sarrión 1; David Alonso1; Roger
Gibert1; Josep Mª Gibert2; Ileana García2; 1Konik-Tech, S.A.,
Sant Cugat Del Vallés, Spain; 2KONIK Instruments, Miami,
FL
Design of a High Throughput Atmospheric Pressure
Interface with Improved Ion Transmission at High
Pressure; Eloy R. Wouters1; Satendra Prasad1; Alexander
A. Makarov2; Jean-Jacques Dunyach1; 1Thermo Fisher
Scientific, San Jose, CA; 2Thermo Fisher Scientific (Bremen)
GmbH, Bremen, Germany
Velocity-map Imaging Mass Spectrometry: Electron
Impact Ionization; James Bull; Jason Lee; Claire Vallance;
University of Oxford, Oxford, UK
A Novel Ion-Optical Design for Laminarization of
Under-Expanded Gas Flows; Diamantis Kounadis1;
Dimitris Papanastasiou1; Ioannis Orfanopoulos1; Alexander
Lekkas1; Athanasios Zacharos1; Ioannis Nikolos2; Emmanuel
Raptakis1; 1Fasmatech, Athens, Greece; 2Technical
University of Crete, Chania, Greece
A Novel Front-End Automation Approach for Sample
Introduction, Cleanup and Collection; Emile Koster; Anne
Vos; Spark Holland, Emmen, Netherlands
Progress Towards the Development of a Combined
Molecular and Atomic Spectrometry System: SonicSpray Ionization MS with Laser Induced Breakdown
Spectroscopy; Katerina Kanaki1; Olga Kokkinaki2; Kostas
Marmatakis1, 2; Demetrios Anglos1, 2; Spiros Pergantis1;
1
University of Crete, Heraklion, Greece; 2IESL-FORTH,
Heraklion, Greece
Core Excitation and Specific Dissociation of DNA
Carbohydrate, 2-Deoxy-D-Ribose; Chen-Lin Liu; NSRRC,
Hsinchu, Taiwan
Novel bi-polar ion detector with avalanche diode; Hiroshi
Kobayashi; Motohiro Suyama; Hamamatsu Photonics K.K.,
Iwata, Japan
Space-Charge Shifts of the Cyclotron Mode Frequencies
in Multi-Species Ion Plasmas; Matthew Affolter; Francois
Anderegg; C. F. Driscoll; DHE Dubin; UCSD, La Jolla, CA

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Duty Cycle-Based Isolation in Linear Quadrupole Ion
Traps; Peter TA Reilly1; Rachit Singh2; Vivek Jayaram2;
1
Washington State University, Pullman, WA; 2Pullman High
School, Pullman, WA
Peptides: Fragmentation Mechanisms, 110 – 123

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Sequence Scrambling in Collision-Induced Dissociation
(CID) of y-Type Fragment Ions; Mahsan Miladi1; Brett
Harper1; John Badger2; Nabeel Hashmi2; Touradj Solouki1;
1
Baylor University, Waco, TX; 2University of Maine, Orono,
ME
Modulating SOH versus CH2SO Loss in Arginine
Containing Dipeptide Sulfinyl Radical Cations; Lei Tan;
Joseph S. Francisco; Yu Xia; Purdue University, West
Lafayette, IN
Electron Transfer Dissociation (ETD) of Peptides
Containing Two Intra-Chain Disulfide Bonds; Lei Tan;
Kirt Durand; Xiaoxiao Ma; Yu Xia; Purdue University, West
Lafayette, IN
Collision-Induced Dissociation (CID) of Dipeptide
Sulfinyl Radical Ions (SO•CX); Lei Tan; Hanfeng Hu; Xia Yu;
Department of Chemistry Purdue University, West Lafayette,
IN
Energy Dependent Reactions between Cysteine Sulfinyl
Radical (SO•Cys) and Thiol (-SH) Within Gas-Phase
Polypeptide Ions; Kirt Durand; Xiaoxiao Ma; Yu Xia;
Purdue University, Lafayette, IN
Effects of C-terminal Amide vs Carboxylic Acid Groups
on the Dissociation of Deprotonated Model Peptides
Containing Acidic Residue; Ahmet Emin Atik1; Carolyn J.
Cassady2; Talat Yalcin1; 1Dept. of Chemistry, Izmir Institute
of Technology, Izmir, Turkey; 2Dept. of Chemistry, The
University of Alabama, Tuscaloosa, AL
Effects of Metal Cationization on Electron Transfer
Dissociation of the Acidic Peptide Human
Fibrinopeptide B; Juliette J. Commodore; Carolyn J.
Cassady; The University of Alabama, Tuscaloosa, AL
Characterization of Peptide Disulfide Regio-Isomers
via Atmospheric Pressure Ion/Radical Reactions and
Tandem Mass Spectrometry; Xiaoxiao Ma; Craig Stinson;
Yu Xia; Purdue University, West Lafayette, IN
Mass Spectrometry Investigation of Elastin-Mimetic
Peptides with Unnatural Amino Acids Substitution;
Gianluca Giorgi1; I-Lin Wu2; Vincent P. Conticello2;
1
Department of Chemistry, University of Siena, Siena, Italy;
2
Department of Chemistry, Emory University, Atlanta, GA
A New Rearrangement Reaction of Peptide b Ions
Containing Acetylated Lysine Residue; Ahmet Emin Atik1;
Oscar Hernandez2; Philippe Maître2; Talat Yalcin1; 1Dept.
of Chemistry, Izmir Institute of Technology, Izmir, Turkey;
2
Laboratoire de Chimie Phys., Université Paris Sud, Orsay,
France
Tandem Mass Spectrometry for the Structural
Characterisation of Peptoids that are Peptidomimetics
for Antimicrobial Peptides; Lauren R. Mackay; Steven L.
Cobb; Jackie A. Mosely; Durham University, Durham, UK
Spectral Immonium Ion Detection (SPIID): A Software
Tool to Systematically Discover New Diagnostic
Fragment Ions in Tandem Mass Spectra; Christian
Kelstrup; Jesper V. Olsen; Michael L. Nielsen; CPR,
University of Copenhagen, Copenhagen N, Denmark
Electron detachment / Photodetachment Dissociation
Mechanisms of Natural and Modified Microcin J25
Lasso Peptides; Marie Pérot-Taillandier1; Carlos Afonso2;
Quentin Enjalbert3; Rodolphe Antoine3; Philippe Dugourd3;
Richard B. Cole4; Jean-Claude Tabet4; Sylvie Rebuffat1;

61ST ASMS CONFERENCE ON MASS SPECTROMETRY

TUESDAY POSTERS

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Séverine Zirah1; 1National Museum of Natural History; UMR
7245, Paris, France; 2Normandie Univ UMR 6014, FR 3038;
Univ Rouen; CNRS, Mont-Saint-Aignan, France; 3University
Claude Bernard of Lyon; UMR 5579, Lyon, France;
4
University Pierre & Marie Curie; UMR 7201, Paris, France
Modification of the Prolyl Ring of Val-Pro-Ala and the
Impact of this Modification on b2 ion Structure; Matthew
Bernier1; Ashley Gucinski2; Julia Chamot-Rooke3; Vicki
Wysocki1; 1The Ohio State University, Columbus, OH; 2U.S.
FDA, Saint Louis, MO; 3Institut Pasteur, Paris, France

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Peptides: Ion Activation/Dissociation Strategies, 124 – 128
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Peptide Sequencing by MALDI Using Negative Ion
Mode In-Source Decay; Chelsea L. McMillen; Patience
Wright; Qiaoli Liang; Carolyn J. Cassady; The University of
Alabama, Tuscaloosa, AL
A Study of Non-Covalent Complexes between Peptides
Containing Multiple Binding Sites Using CID, HCD and
ETD; Ludovic M. Muller; Luciana Tovo Rodrigues; Shelley
N. Jackson; Aurelie Roux; Amina S. Woods; NIH/NIDA-IRP,
Baltimore, MD
Gas-Phase Platination of Peptides via Ion/Ion
Reactions: Selective Cleavage at Sulfur-Containing
Residues; Alice Pilo; John Stutzman; Scott McLuckey;
Purdue University, West Lafayette, IN
De novo Sequencing of Unusual Non Tryptic Peptides
Thanks to 4-sulfophenylisothiocyanate Derivatization
by Post-Source Decay MALDI-MS; Julien Echterbille1;
Loic Quinton1; Pierre Escoubas2; Nicolas Gilles3; Edwin De
Pauw1; 1Universtiy of Liege, Liege, Belgium; 2Venometech,
Valbonne, France; 3IBiTecS SIMOPRO CEA, Gif-sur-Yvette,
France
Enhanced ETD in Tryptic Digests of Complex Samples
by Derivatizing Peptide Carboxyl Groups; Brian L.
Frey; Daniel Ladror; Samuel B. Sondalle; Lloyd M. Smith;
University of Wisconsin, Madison, WI

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Peptides: Quantitative Analysis I, 129 – 163
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Specificity of SRM Measurements: Contributions
of Mass Accuracy, Number of Transitions, Liquid
Chromatography Separations, and MS3; Konstantinos
Petritis1; Tony Tegeler1; Patrick Pirrotte1; Waibhav Tembe1;
Jianqiu Zhang2; Jian Liu1; 1Translational Genomics
Research Institute, Phoenix, AZ; 2University of Texas, San
Antonio, TX
Developing Target-specific MRM Assay for Protein
Quantification: An Empirical Example; Bob Xiong1;
Lance Miller1; Kendall Powell1; Brian Nofsinger1; Mike
Allen1; Robert Hammer2; Sam Massoni2; 1Tandem Labs RTP, Durham, NC; 2New England Peptide, Gardner, MA
Improving Throughput for Highly Multiplexed
Targeted Quantification Methods Using Novel APIremote Instrument Control and State-Model Data
Acquisition Schemes; Amol Prakash1; Scott Peterman1;
Barbara Frewen1; Andreas Kuehn2; Gene Ciccimaro3;
Tara Schroeder3; Lisa Vasicek6; Brian Hood6; Ryan
Bomgarden4; Bryan Krastins1; David Sarracino1; Gregory
Byram1; Maryann Vogelsang1; Jonathan Worboys5;
Claus Jorgensen5; Thomas Conrads6; Mary Lopez1;
1
ThermoFisher Scientific BRIMS, Cambridge, MA;
2
ThermoFisher Scientific Bremen, Bremen, Germany;
3
ThermoFisher Scientific Somerset, Somerset, NJ;
4
ThermoFisher Scientific Rockford, IL; 5Institute for Cancer
Research, London, UK; 6Women’s Integrated Research
Center at Inova Health, Annandale, VA

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The Effect of a Newly Redesigned Triple Quadrupole
Mass Spectrometer on Targeted Peptide Quantitation;
Michael Bereman 1; Richard Johnson1; Reiko Kiyonami2;
Harald Oser2; Mary Blackburn2; Brendan MacLean1; Andy
Hoofnagle1; Michael MacCoss1; 1Univ of Washington,
Seattle, WA; 2Thermo Fisher Scientific, San Jose, CA
Effect of Using Non-identical Peptides as Internal
Standards; Richard S. Johnson; Gennifer Merrihew;
Michael MacCoss; University of Washington, Seattle, WA
Techniques to Improve Multiple Reaction Monitoring
(MRM) Assay Development Efficiency; David Cox 1;
Christie Hunter2; 1AB Sciex, Concord, Canada; 2AB Sciex,
Foster City, CA
Intact versus Signature Peptide Approach to Reach
Optimal Sensitivity in Large Molecule Quantification
by LC-MS: Exenatide Case Study; Jean-Nicholas Mess;
Daniel Villeneuve; Fabio Garofolo; Algorithme Pharma Inc.,
Laval, Quebec, Canada
Exploring the Sensitivity Differences for Targeted
Peptide Quantification in the Low Flow Rate Regime;
Tina Settineri1; Christie Hunter2; Remco van Soest1; Xiang
Zhu1; 1Eksigent, part of AB SCIEX, Dublin, CA; 2AB SCIEX,
Foster City, CA
Increasing the Multiplexing of High Resolution Targeted
Peptide Quantification Assays Using a Scheduled High
Resolution MS/MS Workflow; Mark Cafazzo; AB SCIEX,
Framingham, MA
Dynamic Setting of Acquisition Parameters for High
Resolution / Accurate Mass Quantitative Analyses
Using a Quadrupole-Orbitrap Instrument; Bruno Domon;
Sang-Yoon Kim; Sebastien Gallien; Luxembourg Clinical
Proteomics Center, Strassen, Luxembourg
High Resolution Pseudo MRM Peptide Assays on a
QTOF Instrument; Dominic Helm1; Benjamin Ruprecht1;
Simone Lemeer1; Christopher J Hughes2; Johannes
PC Vissers2; James I Langridge2; Bernhard Kuster1;
1
Technische Universität München, Freising, Germany;
2
Waters Corporation, Manchester, UK
Advanced Use of High Resolution Mass Spectrometry
(HRMS) to Overcome Triple Quadrupole Limitations in
Large Molecules Quantification; Louis-Philippe Morin;
Jean-Nicholas Mess; Milton Furtado; Fabio Garofolo;
Algorithme Pharma Inc., Laval, Quebec, Canada
Finding the Unexpected in SWATH™ Data Sets Implications for Protein Quantitation; Ron Bonner;
Stephen Tate; Adam Lau; AB SCIEX, Concord, Canada
Protein Profiling across Large Sets of Samples: A
Comparison of SWATH-acquisition with Shotgun LCMS/MS and LC-MRM Using a “Gold-Standard-SampleSet”; Roland M. Bruderer1, 2; Saša M. Miladinović1, 2; Oliver
Rinner1; Rudolf Aebersold2; Lukas Reiter1; 1BiognoSYS
AG, Schlieren, Switzerland; 2Institute of Molecular Systems
Biology. ETH, Zurich, Switzerland
Universal Approach to Relative Quantitation of
Proteomic Data Using a Novel Library of Peptide
Standards; Michael Heaven1; Archie Cobbs2; Landon
Wilson1; Matthew Renfrow1; Stephen Barnes1; Michael
Brenner1; Jeremy Norris3; 1Univ. of Alabama at Birmingham,
Birmingham, AL; 2Vulcan Analytical, Birmingham, AL;
3
Vanderbilt University, Nashville, TN
Automated Protein Expression Analysis – A Procedure
Robust to Experimental Variance; Gordana Ivosev;
Stephen Tate; Ron Bonner; Lyle Burton; AB Sciex,
Concord, Canada

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FDR of “Different”: empirical, Probability Based
Determination of Up- and Down-Regulation in
Quantitative Proteomics; John Wilson; Darryl D. Pappin;
Cold Spring Harbor, Cold Spring Harbor, NY
Peptide Peaks Growing Up in a Tough Chromatographic
Neighborhood: Characterizing MRM Reproducibility
and Robustness in Complex Microbial Samples; Adam
Martin1, 2; Paul Abraham1, 2; Rachel Adams1, 2; Robert
Hettich1; 1Oak Ridge National Laboratory, Oak Ridge, TN;
2
University of Tennessee, Knoxville, TN
Lessons Learned: What to Expect when Using MS1and MS2-based Label Free Methods for Quantification;
Jan Muntel1; Sarah A. Boswell2; Waltraud Mair1; Judith A.
J. Steen1; Michael Springer2; Hanno Steen1; 1Children’s
Hospital Boston, Boston, MA; 2Harvard Medical School,
Boston, MA
Automation of the Multiplexed Peptide immuno-MRMMS Workflow on Bravo AssayMAP Platform; Eric Kuhn1;
Lola Fagbami1; Zach Van Den Heuvel2; Steve Murphy2;
Jacob Jaffe1; Steve Carr1; 1Broad Institute, Cambridge, MA;
2
Agilent Technologies, Santa Clara, CA
Carry-Over Issue in LCMSMS Bioanalysis with a
Peptide-like Compound; Marc Fournier; Nathalie Pelletier;
Nadine Boudreau; Ann Lévesque; PharmaNet Canada,
Quebec, Canada
Quantitative Bottom-Up Proteomics Depends on
Digestion Conditions; Mark Lowenthal; Yuxue Liang;
Stephen Stein; Karen Phinney; National Institute of
Standards and Technology, Gaithersburg, MD
Approaching Nanoflow Level Sensitivity Using
Microflow Rates for Peptide Quantitation; Kelli Jonakin;
Christie Hunter; ABSCIEX, Foster City, CA
Selectivity and Sensitivity Evaluation in Peptide
Quantification by Using LC-SRM3 and LC-Differential
Ion Mobility Spectrometry Approaches; Bandar
Alghanem1; Dario Bottinelli1; Ying Zhang1; Aivett Bilbao1,
3
; Frédéric Nikitin3; Markus Mueller3; Frédérique Lisacek3;
Jeremy Luban2; Caterina Strambio De Castillia2; Emmanuel
Varesio1; Gérard Hopfgartner1; 1University of Geneva,
Geneva, Switzerland; 2University of Massachusetts,
Worcester, MA; 3Swiss Institute of Bioinformatics, Geneva,
Switzerland
SF6: A Robust and Effective Proton Transfer Reagent
for Improved Accuracy in Quantitative Proteomics
through Precursor Ion Purification; Arne Ulbrich; Aaron
R. Ledvina; Christopher M. Rose; Michael S. Westphall;
Joshua J. Coon; University of Wisconsin, Madison, WI
Comparison of Automated Protocols for Quantitative
Profiling of Peptides in Brain Tissue Extracts by
High Throughput MALDI-TOF MS; Elena V Romanova;
Jonathan V Sweedler; University of Illinois at UrbanaChampaign, Urbana, IL
Mixture Effects on Peptide Quantification by MALDI MS;
Kd Priyasantha; Mary Kinsel; Gary Kinsel; Southern Illinois
University, Carbondale, IL
SILAC Peptide Ratio Calculator - A New Tool for Robust
SILAC Peptide Quantitation; Xiaoyan Guan; Neha
Rastogi; Mark Parthun; Michael A. Freitas; Ohio State
University, Columbus, OH
Expression of Mutant Proteins as Reagents for LCMRM Assay Development and Internal Standards for
Quantification; Elizabeth Remily-Wood1; Nicholas Woods1;
Robin Hurst2; Michael Rosenblatt2; Alvaro Monteiro1; John
Koomen1; 1H. Lee Moffitt Cancer Center, Tampa, FL;
2
Promega, Madison, WI

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Proteomic Analysis of Mouse Macrophage (RAW264.7)
Cells Infected with Burkholderia pseudomallei K96243;
Zhaojing Meng1; King Chan1; Ming Zhou1; David Deshazer2;
1
SAIC-Frederick, Inc., Frederick, MD; 2USAMRIID,
Frederick, MD
Development of a Quantitative LCMS Method for the
Novel Antifungal Compound Occidiofungin using
QuanBrowser and TraceFinder 3.0; Wanjin Tang1;
Jamie K. Humphries2; Lawrence J. Dangott3; Akshaya
Ravichandran1; Leif Smith1; 1Dept of Biology, Texas A&M
University, College Station, TX; 2ThermoScientific, Austin,
TX; 3Protein Chemistry Laboratory, Texas A&M University,
College Station, TX
Absolute Quantification of XRCC4 in Cells and Human
Tissue by LC-MS/MS; Matt Myers; Xiaomin Wang; Celgene
Corporation, Summit, NJ
Quantitative Analysis of Human Progranulin and
Granulin Peptides Using Multiple Reaction Monitoring;
Toshiya Matsubara1, 2; Noriyuki Ojima1; Tairo Ogura1; Ichiro
Hirano1; Susumu Seino2; 1Shimadzu Corporation, Kyoto,
Japan; 2Kobe University Graduate School of Medicine,
Kobe, Japan
Improved Sensitivity and Throughput for LC-MS/MS
Analysis of CB-315 Lipopeptide in Human Urine Using
Micro-elution SPE; Qiuying Zhu1; Laixin Wang1; Toni
Pollock1; Scott Reuschel1; Min Meng1; Qiao Zhan2; Robert
Pawliuk2; David Benziger 2; Gurudatt Chandorkar2; 1Tandem
Labs, Salt Lake City, UT; 2Cubist Pharmaceuticals, Inc.,
Lexington,, MA
New 2-Dimensional Image-Converted Analysis of Liquid
Chromatography and Mass Spectrometry (2DICAL)
Version with an Algorithm for High-Performance Mass
Spectrometry Data; Tomohiro Sakuma1; Miho Banno1;
Masahiro Kamita2; Tesshi Yamada2; Masaya Ono2; 1Mitsui
Knowledge Industry Co.,Ltd., Tokyo, Japan; 2National
Cancer Center Research Institute, Tokyo, Japan
Proteins: Conformation Analysis, 164 – 172

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Probing the Effect of Primary Structure Variance on the
Gas-Phase Conformations of Insulin and Lispro; Brett
Harper; Mahsan Miladi; Behrooz Zekavat; Touradj Solouki;
Baylor University, Waco, TX
Domain-Localized Energy-Resolved Unfolding of NativeLike Protein Structures in the Gas Phase: Corollaries
from Ion Mobility and Electron Transfer Dissociation;
Deepali Rathore; Eric D. Dodds; University of Nebraska,
Lincoln, NE
Structure of Histone H2A/H2B Dimer Analyzed by Ion
Mobility Mass Spectrometry and Molecular Dynamics
Simulation; Kazumi Saikusa1; Sotaro Fuchigami1; Yuuki
Asano1; Aritaka Nagadoi1; Hiroaki Tachiwana2; Hitoshi
Kurumizaka2; Mitsunori Ikeguchi1; Yoshifumi Nishimura1;
Satoko Akashi1; 1Yokohama City Univ., Grad. Sch. of
Nanobioscience, Yokohama, Japan; 2Waseda Univ., Sch. of
Adv. Sci. & Eng., Tokyo, Japan
Protein Conformational Dynamics Studies Using TIMSMS and Theoretical Calculations; John Daniel DeBord;
Emily Schenk; Jaroslava Miksovska; Francisco Fernandez
Lima; Florida International University, Miami, FL
Time-Dependent Labeling of Proteins by Fast
Photochemical Oxidation of Proteins (FPOP); Ben Niu;
Hao Zhang; Don Rempel; Michael Gross; Washington
University, Saint Louis, MO
Electrochemical Generation of Hydroxyl Radicals
for Hydroxyl Radical Footprinting Experiments; Eric
Monroe; Michael Heien; Univ of Arizona, Tucson, AZ

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Photo Activation Dependent Unfolding of Model
Proteins to Analyse the Effect of Deamidation on
Gas-Phase Structure Using Top-Down ECD FTICRMS; Andrew Soulby1, 2; Huilin Li1; Mark Barrow1; James
Scrivens2; Peter O’Connor1; 1Chemistry, University of
Warwick, Coventry, UK; 2Biological Sciences, University of
Warwick, Coventry, UK
Protein Unfolding and Folding in the Gas Phase Probed
by Electron Capture Dissociation; Moritz Schennach;
Kathrin Breuker; University of Innsbruck, Innsbruck, Austria
Differential Isotopic SMTA Amine Labeling for in
Solution Protein Conformation Studies by Top-Down
UVPD and Bottom-up Approaches; Michael Cammarata;
Walter Fast; Hung-wen Liu; Jennifer Brodbelt; University of
Texas, Austin, TX

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Protein Covalent Labeling, 173 – 193
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Covalent Labeling Strategies for the Improvement
of Whole Protein and Large Peptide Sequence
Determination by Electron Transfer Dissociation; Lissa
C. Anderson1; A. Michelle English1; Weihan Wang1; Jeffrey
Shabanowitz1; Donald F. Hunt1, 2; 1Department of Chemistry,
University of Virginia, Charlottesville, VA; 2Department of
Pathology, University of Virginia, Charlottesville, VA
Covalent Labeling of Peptides and Proteins inside
Reverse Micelles is Under Electrostatic Control;
Feng Wang; Rajasekharreddy Ramireddy; Sankaran
Thayumanavan; Richard Vachet; University of
Massachusetts Amherst, Amherst, MA
Catching Protein N-terminus Using Mass Spectrometry
- Insights into Protein/Peptide Modification and
Enrichment; Eva Zakoucka2; Petr Man1, 2; Alan Kadek1,
2
; Petr Novak1, 2; Petr Jedelsky2; Jan Tachezy2; 1Institute
of Microbiology, Prague 4, Czech Republic; 2Faculty of
Science, Charles University, Prague 2, Czech Republic
Identification and Characterization of the Modification
Sites in Formaldehyde-Inactivated Diphtheria Toxin;
Joost P. Uittenbogaard; Ad P.J.M. de Jong; Hugo D. Meiring;
Geert P.M. Mommen; Gideon F.A. Kersten; Bernard Metz;
InTraVacc, Bilthoven, The Netherlands
Unexpected Arginine Biotinylation by
N-Hydroxysulfosuccinimide (sulfoNHS) Linked Biotin
Reagents; Qinfeng Liu; Andres Lam; Kinjal Amin; Campbell
University, Buies Creek, NC
New Evidence for Covalent Binding of
4-Hydroxynonenal to Matrix Metalloproteinase 13 Using
High Resolution Tandem Mass Spectrometry; Makan
Golizeh1; Mohamed Benderdour2; Lekha Sleno1; 1Université
du Québec à Montréal (UQAM), Montreal, Canada; 2Hôpital
Sacré-Coeur, Université de Montréal, Montréal, CA
Large Scale Analysis of Protein-Ligand Binding
Interactions Using a SILAC-Based Proteomics Platform;
Duc T. Tran; Jagat Adhikari; Michael C. Fitzgerald; Duke
University, Durham, NC
Comprehensive Characterization of Citrullinated Sites
in Proteins by Br-Tagging and MALDI TOF/TOF MS;
Sangwon Cha1; Hyelin Seo1; Eunbi Shin1; Eun Young Lee2;
1
Hankuk University of Foreign Studies, Yongin, South Korea;
2
Seoul National University Hospital, Seoul, South Korea
Can Structural Elements of Proteins be Identified
by Mass Spectrometry and Rapid Derivatization in
Electrospray Plumes? Paul Martino1; Ga-Ram Han1;
Joshua Denny1; Jennifer Bowman1; Chance Lewis1; Douglas
Steiner2; Daniel Therrien2; 1Carson-Newman University,
Jefferson City, TN; 2Montana Tech, Butte, MT

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MeCAT Labelling and ESI MS – A New Means to Quantify
Proteins in Extracts; Gunnar Schwarz1; Rene Becker1;
David Benda1; Violette Frochaux1; Sebastian Beck1; Hartmut
Schlueter2; Michael Linscheid1; 1Humboldt-Universitaet zu
Berlin, Berlin, Germany; 2Universitaetsklinikum HamburgEppendorf, Hamburg, Germany
Covalent Labeling with Isotopically Encoded Reagents
for Improved Structural Analysis of Proteins; Yuping
Zhou; Richard Vachet; University of Massachusetts,
Amherst, MA
Mass Spectrometry in the New World of Tight-Binding
Slow Off-Rate Inhibitors; Philip Ross; AstraZeneca PLP,
Waltham, MA
Insulin as a Model for Amyloid-Beta Fibril Inhibition
Studies Using Rapid Derivatization in Electrospray
Plumes; Jeddidiah Griffin; Paul Martino; Carson-Newman
University, Jefferson City, TN
Synthesis and Characterization of NHS Ester
Conjugated Magnetic Nanoparticles for Labeling
Primary Amine Groups in Proteins/Peptides; Ujwal S.
Patil2; Haiou Qu2; Daniela Caruntu2; Charles J. O’Connor2;
Arjun Sharma1, 2; Matthew A. Tarr2; Yang Cai1, 2; 1The
Research Institute for Children, New Orleans, New Orleans,
LA; 2Department of Chemistry, University of New Orleans,
New Orleans, LA
Identification of Phosphorylation of Tyrosines
on Human Kinesin KIF3C Motor Domain by
Organophosphorus Pesticides Using LC-MS/MS; Pei Li;
Michael Bartlett; University of Georgia, Athens, GA
Ultrarapid Protein Folding Studies by Sub-Millisecond
Mixing in Combination with Pulsed Oxidative Labeling
and ESI-MS; Siavash Vahidi; Bradley B. Stocks; Yalda
Liaghati-Mobarhan; Lars Konermann; Univ. of Western
Ontario, London, Canada
On-line Generation of Reactive Intermediates by
Electrochemistry as Approach for Differential Protein
Labeling; Lars Büter1; Helene Faber2; Kristina Wentker2;
Uwe Karst2; 1University of Münster-Graduate School of
Chemistry, Münster, Germany; 2University of Münster,
Münster, Germany
A New Label Free Approach for The Determination of
Reaction Rates in Oxidative Footprinting Experiments;
Eduardo Pilau1; Amadeu Iglesias2; Fabio Gozzo3; 1University
of Maringá, Maringá, Brazil; 2Waters Technology, São Paulo,
Brasil; 3University of Campinas, Campinas, Brazil
Study of Terephthalic Acid as the Radical Dosimeter
in Hydroxyl Radical Protein Footprinting; Boer Xie;
Complex Carbohydrate Research Center, UGA, Athens, GA
Identification of the Antithrombin III-Arixtra Binding
Interface by Rapid Hydroxyl Radical Protein
Footprinting; Qi Gao; Matthew Tessier; Robert Woods;
Joshua Sharp; Complex Carbohydrate Research Center,
Athens, GA

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Structural Characterization of Robo1 IG1-2 Protein
by Hydroxyl Radical Footprinting; Zixuan Li; Complex
Carbohydrate Research Center UGA, Athens, GA

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Tracing Nanoparticle Cellular Entry and Trafficking: A
Proteomics Strategy Coupling Photo-Cross-Linkable
Dendrimer with Mass Spectrometry Quantitation
Approach; Li Yang; Liang Xue; W. Andy Tao; Purdue
University, West Lafayette, IN
Native Cell Surface Protein Labeling by sulfo-NHS
Ester Conjugated Cleavable Affinity Tags; Jiang Qian1, 2;
Ujwal S. Patil2; Arjun Sharma1, 2; Richard B. Cole2; Matthew

Biomolecular Structure, 194 – 205

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A. Tarr2; Yang Cai1, 2; 1The Research Institute for Children,
New Orleans, New Orleans, LA; 2Department of Chemistry,
University of New Orleans, New Orleans, LA
Using Isotopically-Coded Hydrogen Peroxide as
a Surface Modification Reagent for the Structural
Characterization of Prion-Protein Aggregates; Jason
Serpa1; Evgeniy Petrotchenko1; David Wishart2; Christoph
Borchers1, 3; 1University of Victoria-Genome BC Proteomics
Centre, Victoria, Canada; 2University of Alberta, Alberta,
Canada; 3Dept of Biochemistry and Microbiology, U Victoria,
Victoria, Canada
Novel Carbene Labeling Candidates for Topographic
Protein Analysis; Jinyu Ma1; Ryan Bomgarden2; John
Rogers2; Chris Etienne2; David C. Schriemer1; 1University
of Calgary, Calgary, Canada; 2Thermo Fisher Scientific,
Rockford, IL
Simultaneous Oxidation and On-plate Deposition to
Facilitate High Throughput Protein Footprinting by
Radical Probe Mass Spectrometry; Simin Maleknia 1;
Kevin Downard2; 1University of New South Wales, Sydney,
Australia; 2University of Sydney, Sydney, Australia
Charting Calmodulin and Calcium Dependent Structural
Changes of Eukaryotic Elongation factor-2 Kinase Using
351 nm UVPD-MS; John O’Brien; Clint Tavares; Kevin
Dalby; Jennifer Brodbelt; University of Texas, Austin, TX
Thermodynamic Analysis of Protein Folding Reactions
Using a Mass Spectrometry-Based Tryptophan
Modification Protocol; Yingrong Xu; Erin C. Strickland;
Michael C. Fitzgerald; Duke University, Durham, NC
Top-Down And Bottom-Up Structural Analysis of
Fibrillar and Prefibrillar Oligomeric Forms of Amyloid
Aβ Using Covalent Labeling; Alexandra Klinger2; Janna
Kiselar1; Sergei Ilchenko1; Mark R. Chance1; Paul Axelsen2;
1
Case Western Reserve Univ, Cleveland, OH; 2University of
Pennsylvania, Philadelphia, PA
Accuracy and Precision of a New Covalent Modificationand Quantitative MS-Based Proteomics Approach for
Protein-Ligand Binding Analyses in Complex Mixtures;
Erin C. Strickland; Michael C. Fitzgerald; Duke University,
Durham, NC
Targeted Derivatization for a Better MS/MS: Combining
Chemistry and an Interactive Search Algorithm
for Sequencing Peptides above 3500 Da; David
Morgenstern1; Yong Kil2; Wilfred Tang2; Chris Becker2;
Marshall Bern2; David Fenyo1; Beatrix Ueberheide1; 1New
York University Langone Medical Center, New York City, NY;
2
Protein Metrics, San Carlos, CA
Deciphering the Sequence Specificity of Protein
Citrullination of Glial Fibrillary Acidic Protein; Dylan
Meyer; Andrew Kuhn; Katherine Herting; Jennifer Grant;
Univ. Wisconsin- Stout, Menomonie, WI
A Novel Method to Investigate the Serum Stability of
PEGylated Peptides; Qingyuan Liu; Michael De Felippis;
Jorge Alsina-Fernandez; Lihua Huang; Eli Lilly and
Company, Indianapolis, IN

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Intact Proteins: Quantitative Analysis, 213 – 217
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Intact Proteins: PTM Discovery, 206 – 212
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In-depth Characterization of Intact Myofilament
Proteoforms by Top-down LC/MS-based Proteomics;
Ying Peng; Han Zhang; Matthew Lawrence; Song Jin; Ying
Ge; University of Wisconsin, Madison, WI
Characterization of Human Tropomyosin Molecular
Heterogeneities Using Top-Down Mass Spectrometry;
Deyang Yu1, 2; Ying Peng1, 4; Zachery Gregorich1, 3; Xin Chen1,
4
; Ying Ge1, 5; 1Human Proteomics Program, Madison, WI;
2
Molecular and Environmental Toxicology,SMPH, Madison,
WI; 3Molecular and Cellular Pharmacology Program,

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Madison, WI; 4Department of Cell and Regenerative
Biology,SMPH, Madison, WI; 5Deparment of Chemistry, UWMadison, Madison, WI
Expanding Top Down Proteoform Coverage on Emerin
through Targeted MS2 and Modified Databases Using
ProSightPC 3.0; Robert O’Meally; Raghothama Chaerkady;
Robert Cole; Johns Hopkins School of Medicine, Baltimore,
MD
Functional Characterization of Microbial Proteins Using
the Top-Down Proteomics; Si Wu; Charles Ansong;
Samuel Payne; Roslyn Brown; Da Meng; Rui Zhao; Nikola
Tolic; Yi Qu; Ronald Moore; Mary Lipton; Joshua Adkins;
Ljiljana Pasa-Tolic; PNNL, Richland, WA
Top Down Proteomics Applied to Cultural Heritage;
Sophie Dallongeville; Fabrice Bray; Christian Rolando;
Caroline Tokarski; Université Lille 1, Sciences et
Technologies, Villeneuve d’Ascq, France
Top-Down MS for Clinical Proteomics, Functional
Biology, and Biomarker Validation: Proteotyping CNS
Dysfunction; Steven Patrie; Junmei Zhang; Daniel Plymire;
John Corbett; UT Southwestern Med. Center, Dallas, TX
Online Core-Shell HPLC Protein Separation and
Top-Down Proteomics Using High Resolution Mass
Spectrometry; Christopher Bolcato; Xianglin Yuan; Matthew
Maust; Matthew Powell; Protea Biosciences Group, Inc.,
Morgantown, WV

Quantitative Assessment of Alpha-Synuclein Forms
in Parkinson’s Disease and Normal Brains by Use of
Top-Down Mass Spectrometry; John F. Kellie; John
Ryder; Kalpana Merchant; Michael Knierman; Eli Lilly and
Company, Indianapolis, IN
Bioanalytical Quantitation of Biotherapeutics using
Intact Protein vs. Proteolytic Peptides by LC-HR/AM on
a Q Exactive; Jenny Chen; Jessica wang; Zhiqi hao; Patrick
bennett; greg kilby; Thermo Fisher Sci., San Jose, CA
Development of a Top-Down Approach for
Staphylococcus aureus Enterotoxin A and B Absolute
Quantification; Alexandre Seyer1; Kahina Kachetel1;
Mathieu Dupre1; Francois Fenaille1; Dorothée Lebert2;
Mathilde Louwagie2; Jean-Claude Tabet3; Christophe Junot1;
Virginie Brun2; Francois Becher1; 1CEA, iBiTec-S, SPI,
LEMM, Gif Sur Yvette Cedex, France; 2CEA, DSV, iRTSV,
U1038 INSERM, EDyP, Grenoble, France; 3UPMC, CNRS
UMR 7613, Paris, France
Quantitative Dissection of Polymorphic Neuronal
Receptor Families Using a Selected Reaction
Monitoring-Based Approach; Jovan Simicevic; Dietmar
Schreiner; Erik Ahrné; Peter Scheiffele; Alexander Schmidt;
University of Basel, Basel, SWITZERLAND
Identification and Quantitation of Intact SOD1 Metal
States to Monitor Metal Loading Dysfunction in ALS
Animals Models; Jared Williams; Nathan Lopez; Joe
Beckman; Oregon State University, Corvallis, OR
Intact Proteins: Sequence Analysis, 218 -224

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Systematic Evaluation of Ultrahigh Resolution MS
Instrument Parameter to Optimize Topdown Analysis;
Martin Zeller1; Mathias Mueller1; Eugen Damoc1; Eduard
Denisov1; Alexander Makarov1; Dirk Nolting1; Shannon
Eliuk2; Justin Blethrow2; August Specht2; Thomas Moehring1;
Vlad Zabrouskov2; 1Thermo Fisher Scientific, Bremen,
Germany; 2Thermo Fisher Scientific, San Jose, CA

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Top-Down Analysis of Intact Antibodies Using Orbitrap
Mass Spectrometry; Eugen Damoc; Eduard Denisov;
Alexander Makarov; Thermo Fisher Scientific, Bremen, Germany
Top-down Analysis by LC-MS/MS of Proteins in
Exosomes Shed by Murine Suppressor Cells; Avantika
Dhabaria1; Yan Wang1; Nathan Edwards2; Suzanne OstrandRosenberg3; Catherine Fenselau1; 1University of Maryland,
College Park, MD; 2Georgetown University Medical Center,
Washington, D.C; 3University of Maryland Baltimore County,
Baltimore, MD
Top-down Intact Protein Database Search with Isotopic
Mass-to-Charge Ratio and Envelope Fingerprinting and
ProteinGoggle; Zhixin Tian; Li Li; Bo Wang; Jing Li; Dalian
Institute of Chemical Physics, CAS, Dalian, China
Top-down Assisted Bottom-up Method for Avian
Hemoglobin Sequencing; Yang Stella Song1; Ü nige A.
Laskay2; Alan G. Barbour3; Vicki H. Wysocki1; 1The Ohio
State University, Columbus, OH; 2The University of Arizona,
Tucson, AZ; 3University of California, Irvine, CA
A Front-End ETD Modified Orbitrap-Velos with Ion-Ion
Proton Transfer Reactions and Multiple Fills Provides
Near-Complete Sequence Coverage of Intact Proteins;
A. Michelle English; Lissa C. Anderson; Weihan Wang; Dina
L. Bai; Jeffrey Shabanowitz; Donald F. Hunt; University of
Virginia, Charlottesville, VA
Preferential N-terminal Conjugation as a Strategy
to Sequence N-terminus by ISD-MALDI Top Down
Sequencing Alone; Gomathinayagam Ponniah; Adam Lucka;
Bruce Andrien; Alexion Pharmaceuticals, Cheshire, CT

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Protein Therapeutics: Structural Characterization, 225 – 238
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An Integrated Cross-Platform Workflow for Detecting
Low-Abundance Sequence Variants; Hangtian Song; Wei
Wu; Yunping Huang; Richard Ludwig; Li Tao; Bristol-Myers
Squibb, Hopewell, NJ
New Approaches for MALDI MS-based
Biopharmaceutical Characterization; Marion Rohmer1;
Dominic Baeumlisberger1, 2; Ute Bahr1; Michael Karas1;
1
Goethe University, Frankfurt Am Main, Germany;
2
SunChrom GmbH, Friedrichsdorf, Germany
Optimized HDX-MS Workflow for Analyzing the
Conformation of Therapeutic Antibodies; Pernille
Foged Jensen1; Maximiliane Hilger2; Kasper D. Rand1;
1
University of Copenhagen, Copenhagen, Denmark; 2Roche
Diagnostics GmbH, Penzberg, Germany
Contribution of the Interchain Disulfide Bonds to the
Conformation and Stability of Immunoglobulin as
Revealed by HDX MS; Jing Fang; Jason Richardson;
Zhongqi Zhang; Amgen, Thousand Oaks, CA
Sheathless Capillary Electrophoresis Mass
Spectrometry as a Versatile and Very Powerful Tool
for the Characterization of Monoclonal Antibodies;
Anna Lou1; Jean-Marc Busnel1; Zhiqi Hao2; Dona Neloni
Wijeratne1; David Horn2; Elsa Wagner3; Alain Beck3; Patrick
Bennett2; 1Beckman Coulter, Brea, CA; 2Thermo Fisher
Scientific, San Jose, CA; 3Centre d’Immunologie Pierre
Fabre, Saint-Julien-En-Genevois, FR
Characterization of Lower Molecular Weight Fragments
of Recombinant Monoclonal IgG1 Antibodies Using
Non-Reducing SDS-PAGE and Mass Spectrometry;
Chong-Feng Xu; Li Zang; Yi Wang; Andrew Weiskopf;
Biogen Idec, Cambridge, MA
Characterization of Heterogeneous Therapeutics
by Mass Spectrometry Utilizing Charge Reduction;
Cedric E. Bobst1; Ruth Frenkel2; Damian Houde2; Andrew
Weiskopf2; Igor A. Kaltashov1; 1University of Massachusetts,
Amherst, MA; 2Biogen IDEC, Cambridge, MA

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Characterization and Comparison of O-glycosylation
between the Innovator and a Biosimilar of Etanercept;
Stephane Houel 1; Ying Qing Yu1; Jonathan P. Williams2;
Weibin Chen1; 1Waters Corp., Milford, MA; 2Waters Corp,
Manchester, UK
Glycoform Profiling from Therapeutic Antibodies at
the Protein, Peptide and Cleaved Glycan Level Using
Mass Spectrometry; Chris Hosfield1; Marjeta Urh1;
Michael Rosenblatt1; Richard Jones2; Michael Ford2; Ravi
Amunugama2; Dave Allen2; 1Promega, Madison, WI; 2MS
Bioworks, Ann Arbor, MI
Ion Mobility-Mass Spectrometry Enables the Facile
Characterization of Stapled Peptide Crosslink
Configuration; Eric (Xiangguo) Shi; Vincent Guerlavais;
Krzysztof Darlak; Jim Horstick; Scott Lentini; D. Allen Annis;
Aileron Therapeutics, Cambridge, MA
Isomer-specific LC/MS/MS Characterization of
Biopharmaceutically-Relevant Glycans and Glycan
Modifications; Serenus Hua1; Myung Jin Oh1; Ha Neul
Jeong1; Bum Jin Kim1; Gregory Staples2; Rudolf Grimm1,
2
; Hyun Joo An1; 1Chungnam National University, Daejeon,
Korea; 2Agilent Technologies, Santa Clara, CA
In-Depth Characterization of a Qβ Virus-like Particle
Using High Resolution Mass Spectrometry; Justin B.
Sperry 1; John H. A. Amery1; James A. Carroll1; Jason C.
Rouse2; 1Analytical R&D, Pfizer, Chesterfield, MO; 2Pfizer,
Andover, MA
Characterizing Glycosylation in Therapeutic Antibodies;
Maria Lorna A. De Leoz1, 2; Xinjian Yan1; Xiaoyu Yang1;
Yuxue Liang1; Lisa Kilpatrick1; Yamil Simon1; Michael
J. Tarlov1; Stephen E. Stein1; 1NIST, Gaithersburg, MD;
2
University of Maryland, College Park, MD
LC-MS/MS Analysis of Site-Specific Glycosylation and
Site-Occupancy of Glycoproteins Containing Multiple
N-linked and O-linked Glycosylation Sites; Hongwei Xie;
Song Klapoetke; Jeremy Woods; Linda Yi; Tyler Davis; KBI
Biopharma, Durham, NC
Informatics: Intact Proteins, 239 – 244

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The Lambda Scoring Framework: a Bayesian Posterior
Probability Model to Improve Identification and
Characterization of Top-Down Proteomic Results;
Ryan T. Fellers1; Richard D. LeDuc2; Bryan P. Early1; Paul
M. Thomas1; Neil L. Kelleher1; 1Northwestern University,
Evanston, IL; 2Indiana University, Bloomington, IN
Algorithm for Identification and Sequencing of Protein
Variants Using Top-Down MS Data; Christian Heckendorf;
Roger Theberge; Jean L Spencer; Catherine E Costello;
Mark E McComb; Boston University School of Medicine,
Boston, MA
MIND: A Soft-Sensor to Improve Mass Accuracy in
High-Resolution Top-Down Proteomics; Piotr Dittwald3;
Frederik Lermyte2, 4; Frank Sobott2, 4; Ania Gambin3; Dirk
Valkenborg1, 2; 1Applied Bio & Molecular Systems, VITO,
Mol, Belgium; 2Center for Proteomics, University of Antwerp,
Antwerp, Belgium; 3Computational Biology Group, University
of Warsaw, Warsaw, Poland; 4Biomolec. Mass Spectrometry,
University of Antwerp, Antwerp, Belgium
Identification of Ultramodified Proteins Using Top-Down
Mass Spectra; Xiaowen Liu1; Shawna Hengel 2; Si Wu2;
Nikola Tolic2; Ljiljana Pasa-Tolic2; Pavel Pevzner3; 1IUPUI,
Indianapolis, IN; 2PNNL, Richland, WA; 3UCSD, San diego,
CA
Sequencing Antibodies from Top-Down Spectra; Mikhail
Dvorkin1; Sonya Alexandrova1; Xiaowen Liu2; Si Wu3;
Ljiljana Paša-Tolić3; Nikola Tolić3; Lennard Dekker4; Martijn
Vanduijn4; Theo Luider4; Pavel Pevzner1, 5; Kira Vyatkina1;

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SPb Academic University, St Petersburg, Russian
Federation; 2Indiana University, Indianapolis, IN; 3Pacific
Northwest National Laboratory, Richland, WA; 4Erasmus
MC, Rotterdam, The Netherlands; 5University of California,
San Diego, La Jolla, CA
Autopilot: An Acquisition Control System with
Fragmentation Reanalysis Informed by Online Database
Searching to Optimize Top Down Proteome Analysis;
Ken Durbin; Philip Compton; Ioanna Ntai; Adam Catherman;
Ryan Fellers; Neil Kelleher; Northwestern University,
Evanston, IL

Alexander Koch1; Sandra Steyaert1; Wim Van Criekinge1;
Ghent University, Gent, Belgium; 2VIB-Flanders Institute for
Biotechnology, Ghent, Belgium

1

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Informatics: Systems Biology and
Large-Scale Analyses, 245 – 254
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Comparative Study of Global Protein Turnover in
Tissues and Cell Lines; Martin Damsbo; Jacob Poder;
Erik Nielsen; Christian Ravnsborg; Alexandre Podtelejnikov;
Thermo Fisher Scientific, Odense, Denmark
Quantitative In-Depth Analysis of the Vascular Smooth
Muscle Proteome in a Model of Angiotensin-II Mediated
Hypertrophy; Fernando J. García-Marqués; Elena Bonzón
Kulichenko; Jesus Vazquez Cobos; CNIC, Madrid, Spain
An Automated Program for Protein Turnover
Calculations from LC/MS Shotgun Proteomics Data
Resulting from Partial Metabolic Labelling Experiments;
David Lyon; Molecular Systems Biology, Vienna, Austria
An Integrated Systems Biology Platform for Complete
Proteogenomic Analysis; Pratik Jagtap1; John Chilton1;
Ebbing de Jong2; James Johnson1; Joel Kooren2; Getiria
Onsongo1; Sricharan Bandhakavi3; Timothy Griffin2;
1
Minnesota Supercomputing Institute, UMN, Minneapolis,
MN; 2University of Minnesota, Minneapolis, MN; 3Bio-Rad
Laboratories, Hercules, CA
Scoring Protein Interactions Using CRAPome – A
Contaminant Repository for Affinity Purification Mass
Spectrometry Data; Dattatreya Mellacheruvu1; Zachary
Wright1; Anne-Claude Gingras2, 3; Alexey Nesvizhskii1;
1
University of Michigan, Ann Arbor, MI; 2University of
Toronto, Toronto, Canada; 3Samuel Lunenfeld Research
Institute, Toronto, Canada
Analysis of the STAT3 Interactome Using in-situ
Biotinylation and SILAC; Stefan Kalkhof1; Conny Blumert2;
Riccardo Brumm3; Dirk Labudde3; Friedemann Horn2; Martin
von Bergen1; 1Helmholtz-Centre UFZ, Leipzig, Germany;
2
University Leipzig, Leipzig, Germany; 3University of applied
sciences, Mittweida, Germany
IsoMS: A High-Throughput Data Analysis Software
for Extracting Quantitative Information from Data
Generated by Differential Isotope Labeling LC-MS;
Ruokun Zhou; Chiao-Li Tseng; Liang Li; Department of
Chemistry, University of Alberta, Edmonton, Canada
A Novel Algorithm for Protein Profiling Based on CrossRun Correlations Implemented in the Spectronaut
Software; Oliver M. Bernhardt1; Roland M. Bruderer1, 2;
Tejas P. Gandhi1; Saša M. Miladinović1, 2; Reto Ossola1;
Yulia Butscheid1; Oliver Rinner1; Lukas Reiter1; 1Biognosys,
Schlieren, Switzerland; 2ETH Zurich, Zurich, Switzerland
Identification of More than 8000 Proteins in Single-Runs
in Cancer Cell Lines Using Rigorous, FDR-controlled
Matching between Runs; Nagarjuna Nagaraj; Jurgen
Cox; Matthias Mann; MaxPlanck Institute of Biochemistry,
Martinsried, Germany
Mass Spectrometry and Ribosome Profiling, a
Perfect Combination towards a More Comprehensive
Identification Strategy of True in vivo Protein Forms;
Gerben Menschaert1; Petra Van Damme1, 2; Jeroen Crappé1;

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Comparison of Long-term-non-progressors vs. Normalprogressors among HIV-1 Infected Patients Using
Extensive Ion-Current-Based Proteomic Expression
Profiling Revealed Novel Virus Control Mechanisms;
Xiaomeng Shen1; Xiaosheng Jiang1, 2; Jun Li1, 2; Jun
Qu1, 2; 1University at Buffalo, Buffalo, NY; 2NY CoE in
Bioinformatics and Life Sciences, Buffalo, NY
Differential Proteomics of Monosodium Urate Crystal
Induced Inflammatory Response in Dissected Murine
Air Pouch Membranes by iTRAQ Technology; Chih-Wei
Chiu1; Ying-Chu Shih2; Sung-Fang Chen1; 1National Taiwan
Normal University, Taipei, Taiwan; 2Industrial Technology
Research Institute, Hsinchu, Taiwan
Tandem Affinity Depletion Coupled with Large-Scale,
Extensive Ion Current Based Profiling Revealed
Interesting Plasma Biomarkers Predicting Sudden
Cardiac Arrest; Chengjian Tu 1, 2; Jun Li1, 2; James
Fallavollita1; Rebeccah Young1; Xiaomeng Shen1, 2; Bo An1,
2
; John M. Canty1; Jun Qu1, 2; 1University at Buffalo, Buffalo,
NY; 2NY CoE in Bioinformatics and Life Sciences, Buffalo,
NY
Biomarkers of Western Diet Induced Metabolic Disorder
in Mouse Heart; Stephen A. Whelan; Chunxiang Yao;
Jessica B. Behring; Jean L. Spencer; Deborah A. Siwick;
Wilson S. Colucci; Richard A. Cohen; Catherine E. Costello;
Markus M. Bachschmid; Mark E. Mccomb; Boston University
School of Medicine, Boston, MA
Detection of Endothelial Cell Surface Proteins Following
Irradiation as Potential Targets for Brain Arteriovenous
Malformations; Margaret Simonian2; Nalaka Runnulu1;
rachel Ogorzalek Loo21; Joseph Loo1; Marcus Stoodley2;
Mark Molloy3; 1UCLA, Los Angeles, CA; 2Australian School
of Advanced Medicine, Sydney, Australia; 3Australian
Proteomics Analysis Facility, Sydney, Australia
Quantitative Proteomic Analysis of Saliva in Periodontal
Health, Gingivitis, Mild and Severe Periodontitis, and
Following Periodontal Treatment; Andrew Creese1;
Melissa Grant1; Marcelo Aspiras2; Marko de Jager2;
Helen Cooper1; Iain Chapple1; 1University of Birmingham,
Birmingham, UK; 2Philips Oral Healthcare, Bothell
Quantitative Proteomic Mapping of Gingival Crevicular
Fluid From Dogs Progressing from Mild Gingivitis to
Periodontitis; Andrew W. Jones1; Andrew J. Creese1; Ian
Davis2; Iain L. C. Chapple1; 1College of Medical & Dental
Sciences, University of Birmingham, Birmingham, UK;
2
Waltham Centre for Pet Nutrition, Waltham-on-the-Wolds,
Melton Mowbray, UK
Application of Multi-omic and Functional Network
Analysis for Paediatric Patients Diagnosed with
Idiopathic Nephrotic Syndrome; Lee A Gethings1;
Johannes P.C. Vissers1; John Shockcor2; Stephen
McDonald2; Sandra Kraljević Pavelić3; Mirela Sedic3; Maja
Lemac4; Danica Batinić4; James Langridge1; Olga Vasieva5;
Keith Compson1; 1Waters, Manchester, UK; 2Waters
Corp, Milford, MA; 3University of Rijeka, Rijeka, Croatia;
4
University of Zagreb, Zagreb, Croatia; 5University of
Liverpool, Liverpool, UK
Proteomic Profiling for Peritoneal Dialysate: Differential
Display Analysis for the Protein Expression between
Diabetes Mellitus and Chronic Glomerulonephritis; YiLing Chen1; Ming-Hui Yang2; Yu-Chang Tyan 3; 1Kaohsiung

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Medical University Hospital, Kaohsiung, Taiwan; 2National
Yunlin University of Science & Technology, Yunlin, Taiwan;
3
Kaohsiung Medical University, Kaohsiung, Taiwan
Characterization of the Secretome of Vascular Smooth
Muscle Cells in Response to TGF-β/Smad3 by Labelfree MSE Quantification; Chenxi Yang; Di Ma; Xudong Shi;
K. Craig Kent; Lingjun Li; University of Wisconsin, Madison,
WI
Protein Profile Analysis of Kidney Transplant: Value
in Prognosis of Kidney Failure; Matthew Wroblewski;
William Oetting; Gary Nelsestuen; University of Minnesota,
Minneapolis, MN
Nicotine Alters the Proteome of Pancreatic Cell Lines:
Implications in Pancreatic Disease; Joao A. Paulo;
Steven P. Gygi; Harvard Medical School, Boston, MA
Proteomic Analysis of Matched Normal and Diseased
Formalin-Fixed Paraffin-Embedded Human Breast
Tissues; Fayun Che; jennifer T aguilan; Edward Nieves;
Abdissa Negassa‎; Ruth H Angeletti‎; Thomas E Rohan;
Albert Einstein College of Medicine, Bronx, NY
Protein and Post-Translational Modification Markers in
Sickle Cell Disease; Stephen A Whelan; Roger Theberge;
Jean L Spencer; Paula Griffin; Chuanhua Xing; Martin H
Steinberg; Catherine E Costello; Elizabeth S Klings; Mark
E. Mccomb; Boston University School of Medicine, Boston,
MA
Interference of Protease Inhibitors with Peptidomic
Biomarker Discovery and Peptide Identification;
Diana Klingler1; Markus Hardt2; 1Boston Biomedical
Research Institute, Watertown, MA; 2The Forsyth Institute,
Cambridge, MA
Direct MALDI Analysis of Naturally Cleaved Human
Saliva Samples: Mapping to a Series of KPQ-terminated
Peptides from Small Salivary Proteins; Kenneth
Parker 1; Na Tian2; Frank Oppenheim2; Eva Helmerhorst2;
1
SimulTOF/ VIC Instruments, Sudbury, MA; 2Boston
University School of Dental Medicine, Boston, MA
Identification of Novel Serum Biomarkers for
Preeclampsia with High Predictive Sensitivity; Swati
Anand; BYU, Provo, UT
Proteomic Profiling of Bronchopulmonary Dysplasia
in Preterm Infants; Lindsay Schambeau1; Lewis Pannell1;
John Benjamin2; Chadi Eltaha3; 1USA Mitchell Cancer
Institute, Mobile, AL; 2Vanderbilt University Medical Center,
Nashville, TN; 3University of South Alabama, College of
Medicine, Mobile, AL
Global Quantitative Proteomics of Irradiated Nrf2
Knockout Mus for Biomarker Discovery; Joseph Capri;
Puneet Souda; Upendra Kar; Chris Ryan; William McBride;
Andrew Norris; Julian Whitelegge; UCLA DGSOM, Los
Angeles, CA
Mass Spectrometry Based Quantitative Proteomics for
Discovery of Plasma Protein Biomarkers at Different
Phases of Atherosclerosis; Linhong Jing1; Zhu-qiu
Jin1; Wei Xie1; Shuaipeng Zhang2; 1South Dakota State
University, Brookings, SD; 2Vanderbilt University, Nashville,
Tennessee
SWATH MS Quantification of Human Urine from ICU
Patients Applied to the Quest for Predictive Biomarkers
in Acute Kidney Injury; Peter Pichler1; Ludwig Wagner2;
Christian Baumann3; Michael Schutzbier1; Volker Kruft3; Karl
Mechtler1; 1IMP Vienna, Vienna, Austria; 2Medical University
of Vienna, Vienna, Austria; 3AB SCIEX, Darmstadt,
Germany

Neurodegenerative, Cardiovascular and
Infectious Disease, 276 – 297
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Developing a High-Throughput Clinical Assay Using
Selected Reacion Monitoring-Mass Spectrometry
to Diagnose Parkinson’s Disease; Christine Jelinek1;
Liana Rosenthal1; Rachel Lieberman2; Kevin Meyers3; Ted
Dawson1; Jennifer Van Eyk1; 1Johns Hopkins School of
Medicine, Baltimore, MD; 2Shimadzu Sceintific Instruments,
Columbia, MD; 3Perfinity Biosciences, Inc, West Lafayette,
IN
Identification of Age Dependent Periodontitis
Associated Changes in the Proteome of Whole Human
Saliva By Mass Spectrometric Analysis; Manuela Gesell
Salazar; Annette Murr; Elke Hammer; Nico Jehmlich;
Vishnu Mukund Dhople; Birte Holtfreter; Thomas Kocher;
Uwe Völker; University Medicine Greifswald, Greifswald,
Germany
Identification of Novel Serum Biomarkers for
Alzheimer’s Disease Using an Integrated Serum
Proteomics Method; Dipti Shah; Frederick Rohlfing; Jesse
Cobell; MeiHwa Tanielle Bench Alvarez; John Kauwe;
Steven Graves; Brigham Young University, Provo, UT
Characterization and Quantitation of Alpha-Synuclein
and Subspecies in Human CSF as Candidate
Biomarkers for Parkinson’s Disease; Bekim Bajrami;
Cheryl Lu; Sri Laxmanan; Jaya Goyal; Juan Chavez;
Bernard Ravina; Joleen White; Teresa Compton; Ru Wei;
Biogen Idec, Cambridge, MA
Characterization of the C-terminal End of Soluble
Amyloid Precursor Protein in Human Cerebrospinal
Fluid; Gunnar Brinkmalm 1; Ann Brinkmalm1; Philippe
Bourgeois2; Rita Persson1; Oskar Hansson3, 4; Erik
Portelius1; Marc Mercken5; Ulf Andreasson1; Stéphane
Parent2; Francesco Lipari2; Annika Öhrfelt1; Maria
Bjerke1; Lennart Minthon3, 4; Henrik Zetterberg1, 6; Kaj
Blennow1; Magdalena Nutu1; 1University of Gothenburg,
Mölndal, Sweden; 2PerkinElmer Biosignal, Inc., Montreal,
Canada; 3Lund University, Malmö, Sweden; 4Skåne
University Hospital, Malmö, Sweden; 5Janssen Research
and Development, Beerse, Belgium; 6UCL Institute of
Neurology, London, UK
Comprehensive Analysis of Glycosylation Patterns of
Human Plasma Clusterin - A Putative PTM Marker of
Alzheimer’s Disease; Hui-Chung Liang1; Claire Russell1;
Ray Chung2; Abdul Hye2; Chantal Bazenet2; Simon
Lovestone2; Ian Pike1; Malcolm Ward1; 1Proteome Sciences
plc, London, UK; 2King’s College London, London, UK
Quantitative Proteomic Analysis of Amyotrophic Lateral
Sclerosis-linked Cellular Stress Response with Tandem
Mass Tags; Kristin J. Boggio; John D. Leszyk; Scott A.
Shaffer; Daryl A. Bosco; University of Massachusetts
Medical School, Worcester, MA
Disease Biomarkers for Schizophrenia Reverted
by Antipsychotic Drug Administration: Six-Plex
Quantitative Phosphoproteomics of Prefrontal
Cortex Synaptosomes; Marianne Danielsen1; Kamilla
Sofie Pedersen1; Nadia Taouatas1; Jens D Mikkelsen2;
Henrik H Hansen3; Majbrit M Jensen2; Hans Christian
Beck4; 1Danish Technological Institute, Aarhus, DK;
2
Neurobiology Research Unit, Rigshospitalet, Copenhagen,
DK; 3NeuroSearch A/S, Ballerup, DK; 4Centre for Clinical
Proteomics, OUH, Odense, DK
Validation of Disease Markers in Secretin-Stimulated
Duodenal Juice Using Selected Reaction Monitoring;
Yngvild Bjorlykke1; Erling Tjora1; Fiona E. McAllister3; Frode

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Berven4; Helge Raeder2; 1University of Bergen, Department
of Medicine, Bergen, Norway; 2University of Bergen,
Department of Pediatrics, Bergen, Norway; 3Department
of Cell Biology, Harvard Medical School, Boston, MA;
4
Proteomics Unit (PROBE), University of Bergen, Bergen,
Norway
Systematic Characterization of Human Platelets in
Arterial Vascular Disorders by Quantitative Proteomics;
Julia M. Burkhart1; Marc Vaudel1; Kristin Becker1; Lennart
Martens2; Albert Sickmann1; Rene P. Zahedi1; 1LeibnizInstitut für Analytische Wissenschaften, Dortmund,
Germany; 2VIB Department of Medical Protein Research,
Gent, Belgium
Taking Control: Human Cytomegalovirus Invades Host
Cellular Organelles for Virion Assembly, Maturation,
and Release; Rommel Mathias; Todd Greco; Ileana M.
Cristea; Princeton University, Princeton, NJ
Quantitative Analysis of the Parotid Salivary Proteome
in Patients with Primary Sjögren’s Syndrome; Stephen
Swatkoski1; Kiran Ambatipudi2; James Melvin2; Marjan
Gucek1; 1NIH/NHLBI, Bethesda, MD; 2NIH/NIDCR,
Bethesda, MD
Finding Invasive Aspergillosis Protein Biomarkers in
Patient Bronchoalveolar Lavage Fluid; Chengsi Huang1,
2
; Jason W. McCarthy3; Yun Zhang1; Carmen LuraschiMonjagatta2; Donna Wolk2; KS Knox2; Marta Feldmesser3;
Vicki H. Wysocki1; 1The Ohio State University, Columbus,
OH; 2The University of Arizona, Tucson, AZ; 3Albert Einstein
CoM, Yeshiva University, Bronx, NY
Identification of Plasma Protein and Glycoprotein
Markers of Intestinal Fibrosis Using Lectin Enrichment,
cysTMT Labeling, and LC/MS; Andy Lo; Ryan W. Stidham;
David M. Lubman; University of Michigan, Ann Arbor, MI
Glycomic Profiling and IgG Quantification of HIVInfected Plasma; Cynthia Williams; Anne Fenton; Lauren
Nagy; Qiuting Hong; L.Renee Ruhaak; Satya Dadenkar;
Carlito Lebrilla; UC Davis, Davis, CA
Valley Fever: MS Based Diagnostics and Potential
Vaccine Characterization; Andrew VanSchoiack1; Tao
Peng1; Lourdes Lewis1; John Galgiani1; Vicki Wysocki2;
1
University of Arizona, Tucson, AZ; 2The Ohio State
University, Columbus, OH
Unique Protein Signature of Circulating Microparticles
in Systemic Lupus erythematosus; Ole Østergaard1;
Christoffer T. Nielsen1; Line V. Iversen1; Julia T. Tanassi1;
Steen Knudsen2; Søren Jacobsen3; Niels H. H. Heegaard1;
1
Statens Serum Institut, Copenhagen, Denmark; 2Medical
Prognosis Institute, Copenhagen, Denmark; 3Rigshospitalet,
Copenhagen University Hospital, Copenhagen, Denmark
Analysis of Key Methionine Oxidation in ADAMTS13
from Human Plasma by nanoLC-ESI-MS/MS; Yi Wang1;
Junmei Chen1; William E. Hobbs1; José A. López1, 2; Dominic
W. Chung1, 2; Xiaoyun Fu1, 2; 1Puget Sound Blood Center,
Seattle, WA; 2University of Washington, Seattle, WA
Improvement of a Targeted MS Method used to
Compare Enzyme Levels versus Enzyme Activity
as Tools for Diagnosing Liver Disease; Julie Weisz;
Christine Wu; University of Pittsburgh, Cell Biology,
Pittsburgh, PA
A Novel Hybrid Targeted/Unbiased LC/MS/MS Method
Using Isotopic TMT Enables Superior Peptide Selection
for Clinical MS Assay Development; Christopher Lößner1;
Stephan Jung1; Emma Lahert2; Hans Dieter Zucht1; Stefan
Selzer1; Ian Pike2; Malcolm Ward2; 1Proteome Sciences
R&D GmbH & Co. KG, Frankfurt, Germany; 2Proteome
Sciences plc, London, UK

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Evaluation of a Multiplexed Mass Spectrometry-Based
Method for Measuring Candidate Peptide Biomarkers
in Alzheimer’s Disease Neuroimaging Initiative
(ADNI) CSF; Daniel S. Spellman1; Kristin R. Wildsmith2;
Lee Honigberg2; Angus C. Nairn3; Judith A. Siuciak4, 7;
Mitchel A. Kling5; Howard Schulman6; Michael Schirm6;
Daniel Chelsky6; William Z. Potter4, 7; Alzheimer’s Disease
Neuroimaging Initiative7; Biomarkers Consortium CSF
Proteomics Project Team4; 1Merck and Co., Inc., West
Point, PA; 2Genentech, Inc., South San Francisco, CA;
3
Yale University School of Medicine, New Haven, CT;
4
Foundation of the National Institutes of Health, Bethesda,
MD; 5University of Pennsylvania, Philadelphia, PA; 6Caprion
Proteome, Inc., Montreal, Canada; 7Alzheimer’s Disease
Neuroimaging Initiative (ADNI), Bethesda, MD
Simultaneous Analysis of Tryptophan, Kynurenines
and Several Amino Acids Using GC/Q-TOF in Negative
Chemical Ionization Mode; Anthony Macherone1, 2; Rafael
Acosta1; David Graham2; 1Agilent Technologies, Santa
Clara, CA; 2Johns Hopkins University School of Medicine,
Baltimore, MD

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Screening of 13-HPODE-derived Protein Modifications
by Orbitrap Mass Spectrometry with Isotope Data
Dependent Scan; Ryo Takahashi; Seon Hwa Lee; Takaaki
Goto; Tomoyuki Oe; Tohoku University, Sendai, Japan
New Analytical Platform Based on MS Technologies for
Investigation of Exhaled Breath Condensate (EBC) for
Medical Diagnostics; Igor Popov1, 5; Alexey Kononikhin2,
3
; Konstantin Nagornov2; Nataliia Starodubtseva2, 3;
Anna Ryabokon1; Maria Indeykina1, 2; Evgeny Kukaev1, 5;
Viktoria Kurova1; Alexander Spassky1, 2; Stanislav Pekov2;
Irina Larina4; Sergei Varfolomeev1, 6; Eugene Nikolaev1,
2 1
; Emanuel Institute of Biochemical Physics, Moscow,
Russia; 2Institute for Energy Problems of Chemical
Physics, Moscow, Russia; 3Research Center for Obstetrics,
Gynecology, Moscow, Russia; 4Institute for Biomedical
Problems, Moscow, Russia; 5Moscow Institute of Physics
and Technology, Moscow, Russia; 6Lomonosov Moscow
State University, Moscow, Russia
Optimization of LCMS for Analysis of Small Peptide and
Disulfide Molecules; Usha Mishra; Minnmass(Minnesota
Mass Spec), Minneapolis Mn, MN
Rapid Analysis of Endogenous Steroids Using
Convergence Chromatography Coupled with Mass
Spectrometric Detection; Christopher J. Hudalla1; Stuart
Chadwick2; Fiona Liddicoat2; Andrew Peck1; Kenneth J.
Fountain1; 1Waters Corporation, Milford, MA; 2Waters
Corporation (UK), Manchester, UK
Accelerated Protein Biomarker Discovery with
Microwave & Magnetic (M2) Proteomics; David Black1;
Linda Nagore1; Anjali Purkar1; Swetha Mahesula1; Itay
Raphael1; Jonathan Gelfond2; Stephen Bach1; Thomas
Forsthuber1; William Haskins1, 2; 1University of Texas, San
Antonio, TX; 2University of Texas HSC, San Antonio, TX
Over-Representation of Proteins Identified as Disease
Biomarkers and Their Relation to Post-Mortem Events;
Ulla Sollenberg1; Kim Kultima2; Mats Borén1; Marcus
Söderquist1; Karl Sköld1; 1Denator AB, Gothenburg,
Sweden; 2Uppsala University, Uppsala, Sweden
Calcyclin Levels Determined by High-Throughput SRM
in Serum Samples of Pre-Eclampsia Patients; Coskun
Güzel2; Johannes PC Vissers1; Lennard Dekker2; Gerda
G Zeeman3; Eric AP Steegers3; Theo M Luider2; 1Waters
Corporation, Manchester, UK; 2ErasmusMC, Department
of Neurology, Rotterdam, The Netherlands; 3ErasmusMC,
Department of Gynaecology, Rotterdam, The Netherlands

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The Role of GC/Q-TOF in Exposomics; Anthony
Macherone1, 2; 1Agilent Technologies, Wilmington, DE;
2
Johns Hopkins University School of Medicine, Baltimore,
MD

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Absolute Quantitation of Vitellogenin Using microLCSRM to Determine Reproductive Status of Breeding
Leatherback Turtles, a Non-Sequenced Organism;
Marine Plumel1; Virginie Plot2; Alain Van Dorsselaer1;
Christine Carapito1; Jean-Yves Georges2; Fabrice
Bertile1; 1DSA, IPHC, Strasbourg, France; 2DEPE, IPHC,
Strasbourg, France
Plasma Proteome Kinetics in Nonhuman Primates:
Probing Lipoprotein Synthesis with 2H2O and Targeted
Proteomics; Haihong Zhou; David McLaren; Ablatt Mahsut;
Yi Pan; Ying Chen; Kathy Bierilo; Dan Xie; Steve Stout;
Kithsiri Herath; Keiana Dunn; Alison Kulick; Rui Tang; Ray
Rosa; Marcie Donnelly; Cesaire Gai; Andrew Gewain;
Harmony Lederman; Jose Castro-Perez; Doug Johns;
Michelle Cleary; Stephen Previs; Thomas Roddy; Merck &
Co., Inc., Kenilworth, NJ
Serum Proteomics for Biomarker Discovery Before and
After Antidepressant Treatment of Major Depressive
Disorder; JiYeong Lee1; Hee-Joung Lim2; Jong-Moon
Park3; Kyu Young Lee4; Ju Eun Yi4; HooKeun Lee3; JongHoon Kim2; Eun-Jeong Joo4; Hee-Gyoo Kang1; 1Eulji
University, Seongnam, Korea; 2Korea University, Seoul,
Korea; 3Lee Gil Ya Cancer and Diabetes Institute, Incheon,
Korea; 4School of Medicine Eulji University, Seoul, Korea
Improving Label-Free Quantitation of Plasma and
Serum Proteins Using a High-Resolution Hybrid
Orbitrap Mass Spectrometer; Maryann S. Vogelsang1;
Amol Prakash1; David A. Sarracino1; Scott Peterman1;
Bryan Krastins1; Jennifer N. Sutton1; Gregory Byram1; Gouri
Vadali1; Shadab Ahmad1; Bruno Darbouret2; Mary F. Lopez1;
1
Thermo Fisher Scientific, BRIMS Center, Cambridge, MA;
2
Thermo Fisher Scientific, CD Biomarkers, Nimes, France
Variability in Individual Plasma Protein Profiles over
Time Using SWATH acquisition; Saša M. Miladinović1,
2
; Reto Ossola1; Jasmin van den Heuvel1; Tejas Gandhi1;
Yulia Butscheid1; Oliver Bernhardt1; Lukas Reiter1; Ruedi
Aebersold2; Johan Malstroem1, 3; Oliver Rinner1; 1Biognosys
AG, Schlieren, Switzerland; 2ETH Zurich, Zurich,
Switzerland; 3Lund University, Lund, Sweden
Comparative Proteomic and Metabolomic Analyses
to Study the Effects of Nanoparticle Exposure; Greg
Donohoe; Hossein Maleki; Tim Nurkiewicz; Stephen
Valentine; West Virginia University, Morgantown, WV
Hexafluoroisopropanol as a Novel Reagent for Plasma
Proteomic Analysis; Jon Reed; Ariel Hart; Robert
Pelot; Gogce Crynen; James Evans; Laila Abdulla; Fiona
Crawford; Roskamp Institute, Sarasota, FL
QconCATs for Cholesterol-Related Proteins in
Alzheimer’s Disease; Meiyao Wang; Illarion V. Turko;
IBBR, Rockville, MD
Easy Access to Mass Spectrometry at Multiple Core
Facilities Operating TripleTOF 5600 and Orbitrap Elite/
Velos Pro/Q Exactive Instruments; Anthony Yeung1; Kelly
Jones1; Phillip Kim1; Bhavinkumar Patel1; Kelsen Steven2;
Alan Braverman2; Derrick Swinton3; Philip Gafken4; Lisa
Nader Jones4; William Lane5; John Neveu5; Hon-Chiu
Leung6; Scott Shaffer7; John Leszyk7; Bruce Stanley8;
Todd Fox8; Anne Stanley8; Michael Hall1; Heather Hampel9;
Albert de la Chapelle9; Christopher South9; Randall Burt10;
David Jones10; Levy Kopelovich11; 1Fox Chase Cancer
Center, Philadelphia, PA; 2Temple University School of

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Medicine, Philadelphia, PA; 3Lincoln University, Lincoln, PA;
4
Fred Hutchinson Cancer Center, Seattle, WA; 5Harvard
University, Cambridge, MA; 6Baylor College of Medicine,
Houston, TX; 7University of Massachusetts Medical School,,
Worcester, MA; 8Penn State College of Medicine, Hershey,
PA; 9The Ohio State University, Columbus, OH; 10The U.
of Utah, Salt Lake City, UT; 11National Cancer Institute,
Bethesda, MD
Effects of Chronic Ethanol Consumption on Protein
Expression in Rat Amygdala Studied by Quantitative
Proteomics Using Dimethyl or 18O Labeling; Bill
Huang1; Zheng-Ming Ding2; William McBride2; Hee-Yong
Kim1; 1NIAAA/NIH, Rockville, MD; 2Indiana University
School of Medicine, Indianapolis, IN
Quantitative Proteomic Study of Nucleus Accumbens
in Response to Cocaine Self-Administration in
Environmentally Enriched and Isolated Rats; Cheryl
F. Lichti; Robert D. English; Xiuzhen Fan; Thomas Green;
University of Texas Medical Branch, Galveston, TX
Effect of Chronic Methamphetamine Exposure on the
Proteomics of Different Mouse Brain Tissues; Rui Zhu1;
Tianjiao Yang1; Firas Kobeissy2; Kevin Wang2; Mark Gold2;
Yehia Mechref1; 1Texas Tech University, Lubbock, TX;
2
University of Florida, Gainesville, FL
In vivo Quantitative Proteomics of Somatosensory
Cortical Synapses Shows Which Protein Levels are
Modulated by Sensory Deprivation; Jeffrey Savas1;
Margaret Butko2; Beth Friedman2; Claire Delahunty1;
Ford Ebner3; Roger Tsien2; John Yates III1; 1The Scripps
Research Institute, La Jolla, CA; 2University of California at
San Diego, La Jolla, Ca; 3Vanderbilt University, Nashville, TN
Postsynaptic Density Protein Composition is Altered
in Behaviorally Depressed Adult Female Cynomolgus
Macaques; Stephanie L. Willard1; Karin E. BorgmannWinter1, 2; Matthew L. MacDonald1; Carol A. Shively3;
Chang-Gyu Hahn1; 1University of Pennsylvania, Dept
of Psychiatry, Philadelphia, PA; 2Childrens Hospital of
Philadelphia, Philadelphia, PA; 3Wake Forest School of
Medicine, Dept of Pathology, Winston-Salem, NC
Constellation of Synaptic Proteins at the PostsynapticDensity Differentiates Schizophrenia from Normal
Controls; Matthew L Macdonald1; Nathan Yates2; Robert
Sweet1; 1Univ. of Pittsburgh, Dept of Psychiatriy, Pittsburgh,
PA; 2Univ. of Pittsburgh, Genomics and Proteomics Core,
Pittsburgh, PA
Study of Cerebral Proteomics Expression of
Hippocampal Region from Rats Exposed to Stress
Induced by Forced Swimming Using 2D-SDS-PAGE
and MALDI-TOF/TOF; Victor Alfonso Hernández; Enrique
Mejía-Ospino; Nasser Guerrero; Rodrigo Torres-Saez;
Carlos Conde; Universidad Industrial de Santander,
Bucaramanga, Colombia
The Sex Biased Phosphoproteome: A Novel Approach
Towards Understanding The Molecular Basis for Sex
Differences in Neuropsychiatric Diseases; Rita J.
Valentino; Debra A. Bangasser; Zach Plona; Christopher
McKennan; Hua Ding; Steven H. Seeholzer; Children’s
Hospital of Philadelphia, Philadelphia, PA
Targetedmass Spectrometry Based Quantification
and Characterization of SNARE Complexproteins
from Human Brain Tissue; Ann Brinkmalm 1; Gunnar
Brinkmalm1; Henrik Zetterberg1; Rita Persson1; Jenny Ho2,
3
; Martin Hornshaw2, 3; Madalina Oppermann2, 3; William
G Honer4; Kaj Blennow1; Annika Öhrfelt1; 1University of
Gothenburg, Molndal, Sweden; 2Thermo Fisher Scientific,
Hemel Hempstead, UK; 3Thermo Fisher Scientific, Kungens
kurva, Sweden; 4University of British Columbia, Vancouver,
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Quantitative Phosphoproteomic Analysis of
Postmortem Brain Tissues from Healthy and HIVInfected Individuals; Lerna Uzasci1; Avindra Nath2; Robert
Cotter1; 1Johns Hopkins University School of Medicine,
Baltimore, MD; 2National Institute of Health, Bethesda, MD
Effects of Developmental Exposure to a Commercial
PBDE Mixture (DE-71) on Protein Networks in the Rat
Cerebellum and Hippocampus; Witold M Winnik1; Joyce
E. Royland1; Cristina Osorio2; Oscar Alzate2; Prasada Rao
S. Kodavanti1; 1U.S. Environmental Protection Agency,
Research Triangle Park, NC; 2Systems Proteomics Center,
UNC, Chapel Hill, NC
Data-Independent Acquisition with Ion Mobility (HDMSE)
for Analysis of the Mouse Synaptosome Proteome;
Lewis M. Brown; Guomei Tang; Ryan M. Colligan; David
Sulzer; Columbia University, New York, NY
Global Proteome Analysis of Wild-Type and FoxJ1
Knock-Out Mouse Brain Tissues Using a Quadrupole
Orbitrap Mass Spectrometer; Radiance J. Gibson;
Angelito I. Nepomuceno; Nagendran Muthusamy; Shan
M. Randall; Philip L. Loziuk; H. Troy Ghashghaei; David C.
Muddiman; North Carolina State University, Raleigh, NC
Absolute Quantification of the Lignin Biosynthesis
Pathway Proteins and Metabolites in Transgenic
Populus trichocarpa; Zhichang Yang; Jie Liu; Quanzi Li;
Ronald Sederoff; Vincent L. Chiang; David C. Muddiman;
North Carolina State University, Raleigh, NC
Mass Spectrometry-Based Proteome Characterization
of Laser Microdissected Ovary and Oviduct Tissues
from Chickens with Ovarian Cancer; Angelito I.
Nepomuceno1; Adam M. Hawkridge2; James N. Petitte1;
David C. Muddiman1; 1North Carolina State University,
Raleigh, NC; 2Virginia Commonwealth University,
Richmond, VA
In-depth Proteomic Analysis of Rhesus Macaque Testis;
Jing Wang; Yankai Xia; Gaigai Wang; Yueshuai Guo; Tao
Zhou; Yujie Sun; Xuejiang Guo; Zuomin Zhou; Jiahao Sha;
Nanjing Medical University, Nanjing, China
Qualitative and Quantitative Expression Status of the
Human Chromosome 20 Genes in Cancer Tissues
and the Representative Cell Lines; Quanhui Wang1,
2
; Bo Wen1; Shaohang Xu1; Dahai Jiang1; Liang Lin1; Jin
Zi1; Xiaomin Lou2; Haidan Sun2; Chuangbin Chen1; Fengji
Tan1; Siqi Liu1, 2; 1BGI-Shenzhen, Shenzhen, China; 2Beijing
Institute of Genomics, Beijing, China
A Streamlined Proteomic Workflow from Global
Analysis through Parallel Reaction Monitoring with
SID MS for Breast Cancer Tumor Tissue; Matthew
Meyer1; Kelly V. Ruggles2; Petra Erdmann-Gilmore1; Robert
Kitchens1; Jacqueline Snider1; Jeremy Hoog1; Shunqiang
Li1; Jeanne Rumsey1; Sherri R. Davies1; Matthew J. Ellis1;
David Fenyo2; R. Reid Townsend1; 1Washington University
School of Medicine, St. Louis, MO; 2New York University,
New York, NY
Development of an SRM Assay for the Quantification
of HER2 in FFPE Tissue from Breast Cancer; Carine
Steiner1, 2; Pierre Lescuyer1, 3; Jean-Christophe Tille3;
Thomas McKee3; Marlene Thomas4; Miro Venturi4; Laura
Rubbia-Brandt3; Denis Hochstrasser1, 3; Paul Cutler2;
Alexander Scherl3; Axel Ducret2; 1University Hospital
Geneva, Geneva, Switzerland; 2F. Hoffmann-La Roche,
Basel, Switzerland; 3University of Geneva, Geneva,
Switzerland; 4Roche Pharma Research, Penzberg, Germany
An MRM-based Approach for Quantifying
Microheterogeneity in Cancer Tissues; Jeffrey
Whiteaker; Richard Ivey; Lei Zhao; Regine Schoenherr;
Jacob Kennedy; Chenwei Lin; Ping Yan; Amanda Paulovich;
Fred Hutchinson Cancer Research Center, Seattle, WA

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The Detection of Breast Cancer Using Mass
Spectrometry Based Targeted Proteomics; Yun Chen;
Nanjing Medical University, Nanjing, China
Proteomic Investigation of the Mechanism of Infection
of Hepatitis B Virus (HBV) in HepaRG Cells; Catalina
Petrareanu1; Izabela Sokolowska2; Alina Macovei1; Alisa G
Woods2; Costel C. Darie2; Norica Branza-Nichita1; 1Institute
of Biochemistry, Bucharest, Romania; 2Clarkson University,
Potsdam, NY
An Extensive and Reproducible Ion-Current-Based
Method Enabled Large-Scale Pharmacoproteomic
Assessment of Corticosteroid Treatment in 60 Animals;
Eslam Nouri-nigjeh; Siddharth Sukumaran; Chengjian Tu;
Jun Li; Haoying Yu; Debra C. DuBois; Richard R. Almon;
William Jusko; Jun Qu; University at Buffalo, Buffalo, NY
Quantitative Mitochondrial Proteomics Revealed
an Intimate Connection between Insulin Signaling,
Mitochondrial Metabolism, and Aging; Chun-Qing Song1,
2
; En-Zhi Shen1, 2; Mei-Jun Zhang2; Hanqing Zhao3; Yu-Xin
Li2; Wen-Hong Zhang2; Liping Wei2, 3; Meng-Qiu Dong1,
2 1
; College of Biological Sciences, CAU, Beijing, China;
2
National Institute of Biological Sciences, Beijing, China;
3
Center for Bioinformatics, Peking University, Beijing, China
Heat Inactivation Enables Reliable Measurement
of Tissue Proteome; Charlotta Göransson; Marcus
Söderquist; Denator AB, Gothenburg, Sweden
Identification of Proteomic Differentiation Factors in
Beta Cell Development; Christopher Moss1; Holger Russ2;
Roger Higdon1; Matthias Hebrok2; Eugene Kolker1; 1Seattle
Children’s Research Institute, Seattle, WA; 2University of
California, San Francisco, CA
Protein Profiling of Animal Tissues Using Laser
Ablation Electrospray Mass Spectrometry (LAESI-MS);
Trust Razunguzwa; Gregory Boyce; Pamela Williams;
Callee Walsh; Holly Henderson; Brent Reschke; Matthew
Powell; Protea Biosciences, Morgantown, WV
Epigenetic Modifications/Histones, 342 – 356

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WCX-HILIC Coupled to Middle-Down ECD Mass
Spectrometry for Histone Post-Translational
Modifications Analysis; Annie Moradian 1; Michael
Sweredoski1; Anastasia Kalli2; Sonja Hess1; 1California
Institute of Technology, Pasadena, CA; 2Children’s Hospital
Los Angeles, Los Angeles, CA
Quantitative Histone Proteoform Dynamics with Top
and Middle Down FT-ICR Mass Spectrometry; Xibei
Dang; Yeqing Tao; Jenna Scotcher; Nicolas L. Young;
NHMFL / FSU, Tallahassee, FL
Dynamic Changes in Histone Post-Translational
Modifications During the Cell Cycle by Top-Down MS/
MS Analysis; Xibei Dang1, 2; Jenna Scotcher1; Yeqing Tao1,
2
; Takayo Sasaki2; David M. Gilbert2; Alan G. Marshall1, 2;
Nicolas L. Young1; 1National High Magnetic Field Laboratory,
Tallahassee, FL; 2Florida State University, Tallahassee, FL
Investigations of Histone H2B Isoform Function Using
Top and Middle-down Mass Spectrometry; Rosalynn
Molden1; Anna Arnaudo1; Nicolas Young2; Benjamin
Garcia3; 1Princeton University, Princeton, NJ; 2National High
Magnetic Field Laboratory, Tallahassee, FL; 3University of
Pennsylvania, Philadelphia, PA
Novel Somatic Mutations in Histone H3 are Associated
with Global Histone PTM Changes in Human Pediatric
Glioblastomas; Shu Lin1; Peter Lewis2; Manuel
Müller3; Matthew Koletsky2; Francisco Cordero4; Laura
Banaszynski2; Tom Muir3; Oren Becher4; C. David Allis2;
Benjamin Garcia1; 1University of Pennsylvania, Philadelphia,
PA; 2The Rockefeller University, New York, NY; 3Princeton

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University, Princeton, NJ; 4Duke University Medical Center,
Durham, NC
Development of a Click-Chemistry Based Method to
Quantitatively Study Propagation of Histone PostTranslational Modifications on Newly Synthesized
Nucleosomes; Anna Arnaudo1, 2; Peter DiMaggio3; A James
Link1; Benjamin Garcia2; 1Princeton University, Princeton,
NJ; 2University of Pennsylvania, Philadelphia, PA; 3Imperial
College, London, UK
Quantification of Lysine Crotonylation during in vitro
Human Myogenic Differentiation; Natarajan Bhanu;
Leila Afjehi-Sadat; Benjamin A Garcia; University of
Pennsylvania, Philadelphia, PA
An in vitro Enzymatic Assay for Quantification
of Immediate-Early Histone Modifications in
Compartmentalized Cell Extracts via Mass
Spectrometry; Tobias Maile1; Laura-Mae Britton2; Tom
Januario1; Bob Yauch1; Benjamin Garcia3; David Arnott1;
1
Genentech, South San Francisco, CA; 2Princeton
University, Princeton, NJ; 3University of Pennsylvania,
Philadelphia, PA
A New Strategy for Bottom-Up Analysis of Histone
Posttranslational Modifications Improves Detection and
Quantification of H3K4 Di- and Tri-Methyl Marks; Anita
Izrael-Tomasevic1; Tobias Maile1; Victoria Pham1; Robert
Pitti1; Alexandre Masselot1; Eric Chan2; Patrick Trojer2; Marie
Classon1; David Arnott1; 1Genentech, Inc., S. San Francisco,
CA; 2Constellation Pharmaceuticals, Cambridge, MA
High-Resolution Accurate Mass and Intelligent
Acquisition-Enabled Global Discovery and
Quantification of Histones, PTMs and Modification
Enzymes in Mesenchymal Stem Cells; Amol Prakash1;
Maryann Vogelsang1; David Sarracino1; Scott Peterman1;
Victoria Lunyak2; James Tollervey2; Benny Blackwell2;
Shadab Ahmad1; Gregory Byram1; Bryan Krastins1; Mary
F Lopez1; 1ThermoFisher, Cambridge, MA; 2Buck Institute,
Novato, CA
A Direct LC-MRM Measurement of Histone H3K27
Di-, Tri-Methylation and Acetylation without Lysine
Propionylation; Lei Wang; Yasuhiro Funahashi; Mark
Matijevic; Yoshiya Oda; Eisai Inc, Andover, MA
Quantifying the Effects of FLASH Knockdown On
Regulation of Histone Synthesis by LC-MS/MS;
Joshua A Reavis; Kerry M Bauer; Susan B Skube; Evan S
Merryman; Amanda B Hummon; University of Notre Dame,
Notre Dame, IN
Systems Analysis of Epigenetic Domains – Deducing
the Interactome of Modified Chromatin Using
Quantitative Mass Spectrometry; Miroslav Nikolov1;
Nadin Zimmermann1; Alexandra Stützer1; Efrat Shema2;
Mahmood Haj-Yahya3; Ashraf Brik3; Moshe Oren2; Henning
Urlaub1, 4; Wolfgang Fischle1; 1Max Planck Institute for
Biophysical Chemistry, Göttingen, Germany; 2Weizmann
Institute of Science, Rehovot, Israel; 3Ben-Gurion University,
Beer-Sheva, Israel; 4University Medical Center, Göttingen,
Germany
Studying the Influence of DNA Methylation on a
Translational Level in the DNMT Double Knockout
(DKO) HCT116 Model; Alexander Koch1; Gerben
Menschaert1; Petra Van Damme1, 2; Jolien Hollebeke1, 2;
Wim Van Criekinge1; 1Ghent University, Gent, Belgium;
2
VIB-Flanders Institute for Biotechnology, Ghent, Belgium
Absolute Quantification of Histone Deacetylase
Isoforms Using 15N-labeled Quantification Concatamers
as Internal Standards; Kyle W. Anderson; Junjun Chen;
Illarion V. Turko; IBBR, Rockville, MD

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Off-line High-pH Low-pH 2D-LC Separation Combined
with Isotope Labeling MS for Comprehensive
Metabolome Profiling of Saliva, Serum and Urine
Samples; Tao Huan; Wei Han; Liang Li; University of
Alberta, Edmonton, Canada
Comprehensive Polar Metabolite Analysis in Two
Minutes: Rapid CE-MS Separations Combined with
Ultrafast, High Resolution Time-Of-Flight Mass
Spectrometry; Roza Wojcik; Matthew Giardina; Jeffrey S.
Patrick; Viatcheslav Artaev; LECO Corporation, St. Joseph,
IN
Metabolite Profiling of Carbohydrates and Their
Isomers with Improved Selectivity by Capillary
Electrophoresis-Mass Spectrometry; Naomi Kuehnbaum;
Philip Britz-McKibbin; McMaster University, Hamilton,
Canada
An Automated Microfluidics System for Real-Time
Measurement of Intracellular Metabolites; Joshua
Heinemann; Ece Topulzu; Brian Bothner; Montana State
University, Bozeman, MT
Collision-Cross Sections of Common Cellular
Metabolites to Support Metabolomics Applications;
Giuseppe Paglia1; Giuseppe Astarita2,4; J. Will Thompson3;
Jonathan P. Williams2, 4; James Langridge2, 4; Bernhard
O. Palsson1, 5; 1Center for Systems Biology, University of
Iceland, Reykjavik, Iceland; 2Waters Corporation, Milford,
MA; 3Duke Proteomics Core Facility, Durham, NC; 4Waters
Corporation, Manchester, UK; 5Systems Biology Research
Group, UCSD, San Diego, CA
Comparison and Refinement of UPLC-MS Based Broad
Spectrum Metabolomics Methods; Suraj Dhungana;
Brian F. Thomas; Susan Sumner; RTI RCMRC, RTI
International, Durham, NC
Using Simultaneous Selective Ion Monitoring and
Scan Data Collection to Streamline the Analysis of
Untargeted Metabolomic Datasets Generated by GCMS; Joe Gummer1; Catherine Rawlinson1; Laura Grogan2;
John Hewetson3; Robert Trengove 1; 1Murdoch University,
Murdoch, Australia; 2James Cook University, Townsville,
Australia; 3Shimadzu Scientific Instruments (Oceania),
Sydney, Australia
An IROA (Isotopic Ratio Outlier Analysis) Phenotypic
Analysis of Field-Grown Corn Using High Resolution
Accurate Mass; Josef Ruzicka1; Mark Szewc1; Jan
Hazebroek2; Chris Vlahakis2; Chris Beecher3; 1Thermo
Fisher Scientific, Somerset, NJ; 2DuPont Pioneer, Johnston,
IA; 3NextGen Metabolomics, Ann Arbor, MI
Chemoselective Capture of Carbonyl-Containing
Metabolites for Stable Isotope Resolved Metabolomic
Analysis of Crude Cell Extracts by FTICR-MS; Pawel K.
Lorkiewicz1, 2; Richard M. Higashi1, 2; Stephanie J. Mattingly2;
Michael H. Nantz2; Hunter N. B. Moseley1, 2; Andrew
N. Lane1, 3; Teresa W-M. Fan1, 2; 1CREAM, University
of Louisville, Louisville, KY; 2Department of Chemistry,
University of Louisville, Louisville, KY; 3J.G. Brown Cancer
Center, University of Louisville, Louisville, KY
Protein Sensor for Discrimination of Complex
Metabolite Samples; Timothy Hamerly1; Joshua
Heinemann1; Monika Tokmina-Lukaszewska1; Elizabeth
R. Lusczek2; Kristine E. Mulier2; Greg Beilman2; Brian
Bothner1; 1Montana State University, Bozeman, MT;
2
Department of Surgery - University of Minnesota,
Minneapolis, MN

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A Novel Strategy for Quantification of Primary AmineContaining Metabolites Using N,N-Dimethyl Leucine
Reagents via Capillary Electrophoresis-Electrospray
Ionization-Mass Spectrometry; Ling Hao; Hui Ye; Xuefei
Zhong; Tyler Greer; Dustin Frost; Zhidan Liang; Lingjun Li;
University of Wisconsin, Madison, WI
Material-oriented Tandem MS Libraries for
Metabolomics and Other “-omics” Technologies; Yamil
Simón-Manso1; Kelly H. Telu1; John Halket2; Yuri Mirokhin1;
Stephen E. Stein1; 1NIST, Gaithersburg, MD; 2King’s College
London and Imperial College London, London, UK
Construction of a Plant Natural Products Tandem Mass
Spectral Library; Zhentian Lei1; Li Jing2; Hua Zhang2;
David Huhman1; Zhiqin Zhou2; Lloyd Sumner1; 1The Samuel
Roberts Noble Foundation, Ardmore, OK; 2Southwest
University, Chongqing, China
Understanding Environmental Tobacco Smoke
Exposure and Effects in Asthmatic Children through
Determination of Urinary Cotinine and Targeted
Metabolomics of Plasma; Denise K. MacMillan; R. Dan
Zehr; Barbara Jane George; James L. Crooks; Jane E.
Gallagher; USEPA/NHEERL, Durham, NC
Metabolic Alterations in Breast Cancer Cells and
Mitochondria; Haiwei Gu 1; Daciana Margineantu2;
Danijel Djukovic1; George Rogers3; David Hockenbery2;
Daniel Raftery1; 1University of Washington, Seattle, WA;
2
Fred Hutchinson Cancer Research Center, Seattle, WA;
3
Seahorse Bioscience, North Billerica, MA
Xenobiotic Control of Lung Cancer Metabolism by
activation of the Aryl Hydrocarbon Receptor (AhR);
Sonnet Davis; Alexander Patent; Kylie Mitchell; Arvind
Ramanathan; Buck Institute for Research on Aging, Novato,
CA
A Nutritional Urinary Metabolomics Approach to
Investigate the Effect of Pulse-Based Diets in an
Spontaneously Hypertensive Rat (SHR) Model;
Matthew Hanson2, 3; Carla G Taylor1, 3; Peter Zahradka2, 3;
Michel Aliani1, 3; 1Human Nutritional Sciences, University
of Manitoba, Winnipeg, MB, Canada; 2Dept Physiology,
University of Manitoba, Winnipeg, MB, Canada; 3CCARM,
St. Boniface Hospital Research Centre, Winnipeg, MB,
Canada
Metabolic Rebalancing of CR6 Interaction Factor
1-Deficient Mouse Embryonic Fibroblasts; A Mass
Spectrometry-Based Analysis; Surendar Tadi1, 2;
Soung Jung Kim2; Min Jeong Ryu2; Tae Seong Park3;
Ji-Seon Jeong1; Young Hwan Kim3; Gi Ryang Kweon2;
Minho Shong2; Yong-Hyeon Yim1; 1KRISS, Daejeon,
South Korea; 2Chungnam National University, School of
Medicine, Daejeon, Korea; 3Korea Basic Science Institute,
Cheongwon-gun, Korea
Regulation of Oligodendrocyte Lipid Composition
by mTOR and Metabolomic Profiling of Its Variables;
Richard Schneider1; Caroline Reiss2; Hebe Guardiola-Diaz3;
1
Pfizer Global R&D, Groton, CT; 2Yale University, New
Haven, CT; 3Trinity College, Hartford, CT
Application of nanoLC-MS/MS in a Metabolomics
Study of Acute Kidney Injury in Mice; Stephen Barnes1;
Landon Wilson1; Ali Arabshahi1; Wei Wu2; Sanjay Niggam2;
1
University of Alabama at Birmingham, Birmingham, AL;
2
University of California-San Diego, La Jolla, CA
On-line Detection of Human Stress by Real Time Mass
Spectrometric Monitoring of Skin Volatiles; Ernesto
Criado-Hidalgo1; Guillermo Vidal-de-Miguel1; Rafael BorrajoPelaez1, 2; 1SEADM S. L., Boecillo, Spain; 2University of
California, Irvine, CA

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Finding Potential Biologically Significant Metabolites in
C. Elegans Media Using Global Metabolomics; Yaoling
Long; Puneet Chowdhary; Rebecca Butcher; Nicolas Polfer;
David Powell; Department of Chemistry, University of
Florida, Gainesville, FL
A Metabolomic Analysis of the Effects of Environmental
Stress on Deinococcus radiodurans using LC-MS;
Jingyueh Jeng 1; Chunain Cheng2; Kuan-lin Yu1; 1Chia Nan
Univ of Pharmacy & Science, Tainan, Taiwan; 2National Sun
Yat-sen University, Kaohsiung, Taiwan
High Resolution Peptidomics Links Drug Resistance
to Impaired Hemoglobin Metabolism in the Malaria
Parasite Plasmodium falciparum; Ian A. Lewis; Katelynn
S. Baska; David H. Perlman; Manuel Llinas; Princeton
University, Princeton, NJ
Method for Analysis of Wine and Origin Grape Juice
Properties; Julie Lin1; Michael Athanas1; Mark Dreyer1;
Rose Herbold1; Paul Tarr2; 1Thermo Fisher Scientific, San
jose, Ca, CA; 2California Institute of Technology, Pasadena,
Ca
Untargeted Metabolomics Workflow Using UHPLC/
Quadrupole Orbitrap Mass Spectrometer and SIEVE
2.1; Junhua Wang; David Peake; Yingying Huang; Thermo
Fisher Scientific Inc, San Jose, CA
Metabolomics: Untargeted Metabolite
Profiling Applications, 383 – 419

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Evaluating the Effects of Penicillin Treatment on the
Urine and Plasma Metabolomes of Sprague-Dawley
Rats; Jinchun Sun 1; Laura Schnackenberg1; Sangeeta
Khare1; Xi Yang1; James Greenhaw1; William Salminen2;
Donna Mendrick1; Richard Beger1; 1NCTR / USFDA,
Jefferson, AR; 2PAREXEL International, Boston, MA
UPLC-MS Metabolic Profiling Reveals Involvement
of Novel Biological Pathways in the Progression of
Atherosclerosis; Panagiotis Vorkas1; Joseph Shalhoub2;
Giorgis Isaac3; Elizabeth Want1; Jeremy Nicholson1; Alun
Davies2; Elaine Holmes1; 1Biomolecular Medicine, Imperial
College, London, UK; 2Section of Vascular Surgery, Imperial
College, London, UK; 3Waters Corporation, Milford, MA
Determination of SIRT-3 Dependent Metabolic Changes
in Diabetic Nephropathy Using Novel Metabolomic
Approaches; Suma Ramagiri1; Hari Kosanam2; Kerri Thai3;
Dave Cox1; Lyle Burton1; Eva Duchoslav1; Ron Bonner1;
Andrew Advani3; Richard Gilbert3; 1AB SCIEX, Concord,
Canada; 2Mt.Sinai Hospital, Dept of Pathology and Lab
Med, Toronto, Canada; 3St.Michael’s Hospital, Dept of
Medicine, Toronto, Canada
Multi-platform Metabolomic Study of Burn Injury in a
Rat Model using NMR Spectroscopy and HILIC and
Reverse Phase LC-MS/MS; Sam Li1; Anna Karen Carrasco
Laserna1; Siong Chun Foo1; Shabbir Moochhala2; 1National
University of Singapore, Singapore, Singapore; 2DSO,
Singapore
Direct Analysis of Serum Lipids from Zucker Rats using
High Performance TOFMS – Resolution, Mass Accuracy
and Unsaturation; Jeffrey Patrick; Lucas Smith; Kevin
Siek; Stephanie Amaya; Joe Binkley; LECO Corporation, St.
Joseph, MI
Metabolomics of Opiate-Induced Changes in Murine
Brain by GC/Q-TOF; Manhong Wu1; Peyman Sahbaie1;
Ming Zheng1; David Clark1; Gary Peltz1; Sofia Aronova2;
Stephan Baumann2; 1Stanford University, Stanford, CA;
2
Agilent Technologies, Inc., Santa Clara, CA

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High Accuracy Prostate Cancer Detection Using
Human Blood Sera Metabolomic Profiling; Xiaoling
Zang1; Christina Jones1; Tran Long1; María Monge1;
Manshui Zhou1; L. DeEtte Walker1; Alexander Gray1; John
McDonald1; Nikhil Shah2; Rajesh Laungani2; Facundo
Fernández1; 1Georgia Institute of Technology, Atlanta, GA;
2
Piedmont Hospital, Atlanta, GA
Metabolomic Profiling of Human Breast Cancer
Tissues by UPLC-IM-MS; Kelly Hines1; Billy Ballard2;
Dana Marshall2; John McLean1; 1Vanderbilt University,
Nashville, Tennessee; 2Meharry Medical College, Nashville,
Tennessee
Metabolomic Response of Human Breast Cancer
Lines after Exposure to Estradiol; Liang Zhao; Shelly
Odwin-DaCosta; Mounir Bouhifd; Helena Hogberg; Lena
Smirnova; Andre Kleensang; James D. Yager; Thomas
Hartung; School of Public Health, Johns Hopkins University,
Baltimore, MD
Metabolite Phenotypes Predictive of Non-Small Cell
Lung Cancers; Ji-Won Park1; Hyobin Jeong2; Sujin Kim1;
Byeongsoo Kang2; Hark Kyun Kim3; Daehee Hwang2;
Tae Geol Lee1; 1KRISS, Daejeon, South Korea; 2postech,
Pohang, South Korea; 3NCC, Goyang, South Korea
Biomarkers of Pancreatic Cancer; Suhong Zhang4,
4
; Maya Khezam1, 4; Nathaniel Snyder2, 4; Clementina
Mesaros2, 4; Kenneth Yu3, 4; Ian Blair2, 4; 1Centers for
Excellence in Environmental Toxicology, Philadelphia,
PA; 2Cancer Pharmacology, University of Pennsylvania,
Philadelphia, PA; 3Memorial Sloan-Kettering Cancer Center,
New York, NY; 4, Philadelphia, PA
Metabolomics Investigation of Ovarian Cancer
Progression in a Dicer-Pten Double Knockout Mouse
Model; Christina Jones1; Maria Monge1; Jaeyeon Kim2;
Martin Matzuk2; John McDonald1; Facundo Fernandez1;
1
Georgia Institute of Technology, Atlanta, GA; 2Baylor
College of Medicine, Houston, TX
Metabolic Profiling of Gottingen Minipig Plasma Using
GC-MS and LC-MS; Jeffrey Mcguire; US Army ECBC,
Aberdeen Proving Ground, MD
Mass Spectrometry Metabolomics to Identify Novel
Diet-Dependent Plasma Metabolites; Masoumeh
Karimpour1; Izabella Surowiec1; Johan Trygg1; Angela
Zivkovic2; Malin Nording1; 1Department of Chemistry, Umea
University, Umea, Sweden; 2University of California, Davis,
CA
Effect of Exercise on Fatty Acid Metabolism in Aging
Brain; Nataliya Chorna; Ivan Santos; Sandra Pena de Ortiz;
University of Puerto Rico, San Juan, PR
Untargeted Metabolite Profiling of Porcine Urine
Samples: Individual’s Response to Stress During
Hemorrhage, Shock and Recovery; Monika TokminaLukaszewska1; Navid Movahed1; Kristine Mulier2; Nancy
Witowski2; Greg Beilman2; Brian Bothner1; 1Montana State
University, Bozeman, MT; 2Medical School, University of
Minnesota, Minneapolis, MN
Metabolite Profiling of Wild Yeast Strains for Brewing
Makgeolli Depending on the Strains and the in vitro
Physiological Activities; HyeRyun Kim; Jang-Eun Lee;
Jae Ho Kim; Byung Hak Ahn; Korea Food Research
Institute, Seongnamsi, Asia/Pacific Region
Expanding Metabolic Pathways in the Ovarian Tissues
Using Metal-assisted SIMS (MetA-SIMS); Tae Geol Lee1;
Ji-Won Park1; Su Jin Kim1; Byeongsoo Kang2; Hyobin
Jeong2; Hark Kyun Kim3; DaeHee Hwang2; 1KRISS,
Daejeon, South Korea; 2Postech, Pohang, South Korea;
3
NCC, Goyang, South Korea

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Fecal Metabolomics of the Mouse Digestive Tract to
Determine the Effect of Host Antimicrobial Peptides;
Samanthi I. Wickramasekara1; Chunxiao Guo1; Fereshteh
Zandkarimi1; Jeffrey Morré1; Richard L. Gallo2; Adrian F.
Gombart1; Claudia S. Maier1; 1Oregon State University,
Corvallis, OR; 2University of California, San Diego, CA
Exploration of Ethanol-induced Liver disease using
High Performance GC-TOF-MS and Robust Statistical
Analysis; Jeffrey Patrick1; Joe Binkley1; John Heim1; Jens
Hoefkens2; 1LECO Corporation, St. Joseph, MI; 2Genedata
(USA), lexington, MA
Untargeted Metabolomics Reveals Alteration of the
Sphinganine-Ceramide Pathway in Spinal Cord Injury;
Jaewoo Choi; Debbie J. Mustacich; Wendy I. Baltzer; Jan F.
Stevens; Oregon State University, Corvallis, OR
Analysis of Cerebrospinal Fluid to Investigate the Effect
of Iron Deficiency Anemia on the Central Nervous
System Metabolome; Farbod Fazlollahi1; Christopher
Coe2; Gabriele Lubach2; Kym Faull1; 1UCLA, Los Angeles,
CA; 2University of Wisconsin, Madison, WI
Metabolomic Profiling of Obese Pig Colon Mucosa
and Fecal Samples to Study the Effect of Consuming
Anthocyanin-rich Color-fleshed Potatoes; Lavanya
Reddivari1; Sridhar Radhakrishnan1; Sumit Shah2; Jairam
Vanamala1, 3; 1Colorado State University, Fort Collins, CO;
2
Agilent Technologies, Inc, Wakefield, MA; 3University of
Colorado Cancer Center, Aurora, CO
Untargeted Metabolomics Identifies Putrescine as a
Candidate Predictive Biomarker of L-Asparaginase
Response and as an Additive for Possible Combination
Therapy; Leslie Silva; Philip Lorenzi; David Hawke; John
Weinstein; MD Anderson Cancer Center, Houston, TX
Metabolomics of Asbestos Exposure; Clementina
Mesaros; Nathaniel W. Snyder; Anil Vachani; Ian A. Blair;
University of Pennsylvania, Philadelphia, PA
The Metabolomics of Oxidative Stress: Investigating
the Impact of a Sod1-null Mutant and Paraquat
Induced Stress Using Liquid Chromatography/Mass
Spectrometry; Jose M. Knee1; Teresa Z. Rzezniczak1;
Kevin K. Guo3; Aiko Barsch2; Gabriela Zurek2; Thomas
J. S. Merritt1; 1Dept. Chemistry&Biochemistry Laurentian
University, Sudbury, Ontario, Canada; 2Bruker Daltonik GmbH,
Bremen, Germany; 3Bruker Daltonics Inc., Billerica, MA
Untargeted Metabolomics for Profiling Multiple
Auxotrophic Yeast Strains by LC-QqTOF; Lekha Sleno1;
Audrey Ste-Rose1; Guri Giaever2; Corey Nislow2; 1UQAM,
Montreal, Canada; 2UBC, Vancouver, CA
Comprehensive Metabolomic Profiling of Lotus Seeds
from Different Cultivars Using GC-MS and LC- MS;
Ming-Zhi Zhu; Sha Chen; Shao-Hua Li; Ming-Quan Guo;
Wuhan Botanical Garden, Chinese Academy of Science,
Wuhan, China
Metabolomic Analysis of a Staphylococcus Variant
SG1 Cultured in the Absence and Presence of Butanol;
Feifei Fu; Yiman Wu; Victor Cheng; Joel Weiner; Liang Li;
University of Alberta, Edmonton, Canada
Untargeted Metabolomic Analysis of UV Stress
Response in Chlamydomonas reinhardtii Using GCQTOF and GC-TOF Mass Spectrometry; Zipora Tietel;
Kohei Takeuchi; Mine Palazoglu; Oliver Fiehn; UC Davis
Genome center, Metabolomics, Davis, CA
Untargeted Metabolomic Study on the Effect of in vitro
Mineral Nutrition on Raspberry (Rubus idaeus) Growth;
Soyoun Ahn 1, 2; Sukalya Poothong2; Barbara Reed2, 3;
Claudia Maier1, 2; 1EHSC Oregon State University, Corvallis,
OR; 2Department of Horticulture Oregon State University,
Corvallis, OR; 3USDA-ARS, Corvallis, OR

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Metabolomics of Hermaphroditic C. elegans via Isotopic
Ratio Outlier Analysis Using High-Resolution Accurate
Mass LC/MS/MS; Kevin J. McHale1; Mark Szewc1; Gregory
S. Stupp2; Chaevien Clendinen2; Ramadan Ajredini2; Arthur
S. Edison2; Chris Beecher3; 1Thermo Fisher, Somerset,
NJ; 2University of Florida, Gainesville, FL; 3NextGen
Metabolomics, Ann Arbor, MI
Natural Products Drug Discovery from Marine
Invertebrate-Associated Bacteria: Strain Selection
Using Principle Component Analysis of LC/MS Data;
Gregory A. Ellis1; Yanpeng Hou2; Thomas P. Wyche1; Doug
R. Braun1; Navid Adnani1; Emmanuel Vazquez-Rivera1; Tim
S. Bugni1; 1University of Wisconsin School of Pharmacy,
Madison, WI; 2PepsiCo, New Haven, CT
Untargeted Metabolomics for the Discovery of Small
Molecule Regulators of Thermogenesis; Jay Kirkwood;
Cristobal Miranda; Fred Stevens; Oregon State University,
Corvallis, OR
Metabolomics Study or Model Systems for Microbially;
Vincent Bonifay1; Whitney Smith1; Iwona Beech2; Jan
Sunner1; 1Oklahoma University, Norman, OK; 2University of
Portsmouth, Portsmouth, UK
Bacterial Nutritional Growth and Responses to Varying
Nitrogen Sources by IROA Protocol; Chris Beecher1;
Peng Jiang2; Alex Ninfa2; 1NextGen Metabolomics, Ann
Arbor, MI; 2University of Michigan Medical School, Ann
Arbor, MI
Metabolomics of Carbon Fixing Mutants of
Cyanobacteria by GC/Q-TOF; Dong hee Chung1; Christine
Rabinovitch-Deere1; Shota Atsumi1; Sofia Aronova2;
1
University of California, Davis, CA; 2Agilent Technologies,
Inc., Santa Clara, CA
Drug Metabolism: Quantitative Analysis, 420 – 451

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Investigating the Importance of Resolution and Scan
Speed for Qualitative/Quantitative Bioanalysis Using
a Benchtop HR/AM Orbitrap Mass Spectrometer; Brad
Yuska1; Ragu Ramanathan1; Tim Stratton2; Hongxia Wang2;
Frank Morris1; Patrick Bennett2; 1QPS, LLC, Newark, DE;
2
ThermoFisher, San Jose, CA
Analysis of Pharmaceutical Small Molecules Using a
Prototype Microfluidics Tandem Quadrupole LCMS
System; Yun W. Alelyunas1; Mark D. Wrona1; Catalin
Doneanu1; Stephen McDonald1; Paul D. Rainville1; Philip
Tiller2; 1Waters Corporation, Milford, MA; 2RMI laboratories,
North Wales, PA
Development of Ultrasensitive Nanoscale LC/MS
Techniques for Quantification of an HIV-1 Integrase
Inhibitor in Human Plasma; Miaoqing Shen1; Li Sun2;
Kevin Bateman2; Jack Henion1; 1Advion Bioanalytical
Lab, a Quintiles company, Ithaca, NY; 2Merck Research
Laboratories, West Point, PA
Parallel-Micro Liquid Chromatography - Mass
Spectrometry for the Quantification of Pharmaceuticals
using Dried Blood Spot Tube-based Sample Collection
Format; Kyoko Watanabe1, 3; Emmanuel Varesio1; Neil
Loftus2; Gérard Hopfgartner1; 1Université de Genève, Genève,
Switzerland; 2Shimadzu Corporation, MS/BU, Manchester,
UK; 3Shimadzu Corporation, GADC, Kyoto, Japan
Electrochemistry Coupled to LC-ICP-MS for the
Elucidation and Quantitative Assessment of the
Oxidation Pathway of Selected Isatins; Daniel Melles1;
Christoph A. Wehe2; Panupun Limpachayaporn1; Günter
Haufe2; Uwe Karst2; 1University of Münster-Graduate School
of Chemistry, Münster, DE; 2University of Münster, Münster,
DE

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A Novel Direct Analysis in Real Time (DART) Mass
Spectrometry Method for Determination of Imatinib
in Human Plasma; Kumari Ubhayasekera; Warunika
Aluthgedara; Tommy Lewander; Jonas Bergquist; Uppsala
University, Uppsala, Sweden
Evaluation of Centroid and Profile Mode Data Collection
Methods for High Resolution Mass Spectrometry Based
Integrated Qualitative and Quantitative Bioanalysis;
Eldho Raju; Dil Ramanathan; Kean University, Union, NJ
SWATH – A High Resolution Data Independent
Acquisiton Approach to Pharmaceutical/ Biotherapeutic
Quantitation and Retrospective Qualitative
Interrogation; Loren Olson 1, 2; Paul Clemens1, 2; Eva
Duchoslav1, 2; Gary Impey1, 2; 1AB SCIEX, Foster City, CA;
2
AB SCIEX, Toronto, Canada
SWATH Based Pharmacokinetic Quantification to
Increase Selectivity, Specificity and Signal-to-Noise
Ratio with the Benefits of Non-Targeted Approach on
UHPLC-HRMS; Ragu Ramanathan1; Suma Ramagiri2; Brad
Yuska1; Frank Morris1; Jiyi Wang1; Anthony Srnka1; Yves
LeBlanc2; Gary Impey2; Loren Olson2; Helen Shen1; 1QPS,
LLC, Newark, DE; 2AB SCIEX, Concord, Ontario, Canada
Parameter-Free Peak Area Integration for Multiple
Batches of LC/MS/MS Data; Yongdong Wang; Hongliang
(Leo) Xu; Ming Gu; Cerno Bioscience, Norwalk, CT
Pragmatic Approaches to Determine the Exposures of
Drug Metabolites in Pre-Clinical and Clinical Subjects;
Johanna Haglund1, 2; Åsa Brunnström1, 2; Göran Eklund1,
2
; Antti Kautiainen1, 2; Anna Sandholm1, 3; Magnus Halldin1;
Suzanne Iverson Hemberg1; 1AstraZeneca AB, Södertälje,
Sweden; 2MetaSafe AB, Södertälje, Sweden; 3Scandinavian
Development Services AB, Stockholm, Sweden
Evaluate and Overcome the Impact of Hemolysis on
the Quantitation Using LC-MS/MS - Is “Revising SOP”
the Solution? Jing Ke; Yijin Xiao; Kelly Lam; Harry Zhao;
Zhongping (John) Lin; Frontage Laboratories, Inc, Exton, PA
Automated, Empirical Method Development for SolidPhase Extraction of Pharmaceuticals from Biological
Fluids for LC-MS/MS Analysis; Kc Van Horne1; Phil
Dimson1; Luigi Chanco1; Bruce Redmond1; Jacob Christ2;
David Hall1; 1SPEware Corporation, Baldwin Park, CA;
2
ProLinear/Pontech, Inc., Rancho Cucamonga, CA
Quantitation of Amino Acids in Response to
L-Asparaginase Treatment in Ovarian Cancer; Preeti
Purwaha; Philip L. Lorenzi; David Hawke; John N.
Weinstein; MD Anderson Cancer Center, Houston, TX
UPLC-ESI+-MS/MS Method for Quantitation of
Circulating Levels of 13 Opiate and Opioid Analgesics
from Dried Blood Spot Samples; Melissa Goggin;
Richard Lundberg; Karla Walker; Gregory Janis; MedTox
Laboratories, New Brighton, MN
An LC-MS/MS Method for Quantification of
Debrisoquine and OH-debrisoquine in Dried Blood
Spots; Jason Barricklow; Hongying Gao; Pfizer, Groton, CT
A Sensitive and Selective Liquid ChromatographyTandem Mass Spectrometry Method for Quantitative
Analysis of Efavirenz in Human Dried Blood Spots;
Praveen Srivastava1; Ganesh Moorthy1; Vu Nguyen1;
Robert Gross2; Jeffrey Barrett1; 1The Children’s Hospital of
Philadelphia, Philadelphia, PA; 2University of Pennsylvanaia,
Philadelphia, PA
Quantitative Acetylation Analysis of Mitochondrial
Proteins in Type 2 Diabetic Mice and Treatment of
Metformin; Xiaolu Zhao1; Jie Dai2; Jianshuang Li1; Xiujuan
Zhu1; Ling Zheng1; Ole Nørregaard Jensen2; Lin Guo1;

61ST ASMS CONFERENCE ON MASS SPECTROMETRY

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Wuhan University, Wuhan, P.R.China; 2University of
Southern Denmark, Odense, Denmark
Determination of Norgestrel and Norgestimate in
Human Plasma by LC/MS-MS; Hongkun Liang; crystal
Nguyen; Angel Tseng; Vi Dan; Yuan-Chek Chen; Kumar
Ramu; QPS, LLC., Newark, DE
An LC-MS/MS Assay for Simultaneous Quantitation
of Docetaxel and its Prodrug-Conjugate for
Pharmacokinetic Studies of PRINT-Lipidized-Docetaxel
Nanoparticles in Mice; Allison N Schorzman; Kevin Chu;
Matthew Finniss; Charles Bowerman; Jennifer Kuijer;
Andrew Madden; Joseph DeSimone; William Zamboni;
UNC, Chapel Hill, NC
Characterization of Xylazine Metabolism in Rat Liver
Microsomes by HPLC-QqLIT MS; David St-Germain
Lavoie1; Floriane Pailleux1, 2; Pascal Vachon1; Francis
Beaudry1; 1Université de Montréal, Saint-Hyacinthe,
Canada; 2Université de Lyon, Villeurbanne, France
Validation of the Trans Stereoisomer Enclomiphene
in Human Serum by LC/MS/MS API5000; Adlai
Niggebrugge; Mario Pellerin; Ardeshir Khadang; PRACS
Institute, Fargo, ND
Simultaneous Determination of Pinitol and its
metabolites (Chiro-, Myo-inositol) in Rat Plasma by
LC-MS/MS; Yun Kyoung Choi1; In Young Choi1; Ji Hoon
Jeoung2; Hohyun Kim1; 1Korea Medicine Research Institute,
Inc., Seoungnam, South Korea; 2College of Medicine,
Chung-Ang University, Seoul, South Korea
Quantitation of Praziquantel and Its Metabolites
in Mouse Plasma Using Ultra-Performance
Liquidchromatography- Tandem Mass Spectrometry;
Amy Qiu Wang; Edward Kerns; Xin Xu; Gurmit Grewal;
Philip Sanderson; John Shen; John McKew; NCATS, NIH,
Rockville, MD
Study of the Brain-Uptake of a Non-Radioactive
Pseudo-Carrier for [18F]-AV-133 by Ultra-Performance
Liquid Chromatography Tandem Mass Spectrometry;
Xue Zhou1; Ai-Fang Deng1; Jinping Qiao1; Xian-Ying
Wu1; Yan Zhang1; Wei Yin1; Lin Zhu1; Hank Kung2;
1
Beijing Normal University, Beijing, China; 2Department of
Radiology,University of Pennsylvania, Philadelphia, PA
Highly Sensitive Determination of Desmopressin in
Human Plasma by UPLC-MS/MS; Yun Kyoung Choi1;
Jae Geun Lee1; Ji Hoon Jeoung2; Hohyun Kim1; 1Korea
Medicine Research Institute, Inc., Seoungnam, South
Korea; 2Chung-Ang University, Seoul, South Korea
A Simplified Method for Quantification of Gemcitabine
with LC-MS from Tissue Applied to Research on the
Surgical Delivery of Chemotherapy; Preston Sparks1;
Michael Roach1; Jesse Hines2; 1Eisenhower Army Medical
Center, Fort Gordon, GA; 2Perkin Elmer, Waltham, MA
Mometasone Furoate in Human Plasma by LC/MS/
MS with Column Switch; Allan Xu; Xiaohua Li; Vince
Windisch; Keystone Bioanalytical, North Wales, PA
A Sensitive and Robust Assay for Determination of
Clonidine in Human Plasma Using Derivatization and
LC-MS/MS Techniques; Yansheng Liu; Marsha Luna; Julie
Showalter; Rochelle Burke; Moo-Young Kim; KCAS LLC,
Shawnee, KS
The “Double edge sword” of Hydroxypropyl-betaCyclodextrin on the Quantitative Analysis of a
Lipoglycopeptide and its Hydroxylated Metabolites
by LC-MS/MS; Moucun Yuan; James Waltrip; Song
Zhao; William R. Mylott; Bruce Hidy; Rand Jenkins; PPD,
Richmond, VA
1

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Determination of CTP-499 and Its Major Metabolites
in Dog, Rat and Rabbit Plasma by LC-MS/MS; Xiaonan
Tang1; Jing Ke1; Halil Erol1; Chih Hsien Lin1; Harry Zhao1;
Zhongping (John) Lin1; Changfu Cheng2; 1Frontage
Laboratories, Inc., Exton, PA; 2CoNCERT Pharmaceuticals,
Inc., Lexington, MA
Diastereomeric Separation of Chiral Metabolites
Utilizing SFC-MS/MS; A Powerful Tool to Investigate
Stereoselective Metabolism? Chester L Bowen1;
Hermes Licea-Perez1; Tom DePhillipo2; Denise Heyburn2;
Paul Rainville2; Robert Plumb2; Christopher Evans1;
1
GlaxoSmithKline, King Of Prussia, PA; 2Waters, Milford,
MA
Small Molecules: Quantitative Analysis II, 452 – 477

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Detailed Characterization of Conjugation Pathways of
the Tetrahydro-Reduced Metabolites of Glucocorticoids
by Rat and Human Liver Fractions Using LC/ESI-MS/
MS; Kuniko Mitamura1; Mami Kamibayashi1; Kanta Sato1;
Sachi Fujioka1; Rika Satoh (née Okihara) 2; Takashi Iida2;
Shigeo Ikegawa1; 1Kinki University, Higashi-Osaka, Japan;
2
Nihon University, Tokyo, Japan
Quantitation of Testosterone and Nandrolone Using
Dried Blood Spots (DBS) for Steroid Pharmacological
Study; Gurmeet Kaur Surindar Singh1, 2; Reena Desai1;
Mark Jimenez1; David Handelsman1; 1ANZAC Research
Institute, University of Sydney, New South Wales, Sydney,
Australia; 2Faculty of Pharmacy, Universiti Teknologi MARA,
Kuala Selangor, Selangor, Malaysia
Quantitative Measurement of Fludarabine
Incorporation in Cellular DNA by Enzymology and
Mass Spectrometry; Ye Feng1; Lan Li1; Lili Liu2; Stanton L.
Gerson2; Yan Xu1, 2; 1Cleveland State University, Cleveland,
OH; 2Case Comprehensive Cancer Center, Cleveland, OH
Neurotransmitter Analysis in Rat Brain Microdialysis
Samples Using LC-MS/MS; Changyu Quang; Michael
V. Stoeling; William C. Nethero; Jonathan D. Toot; Eric S.
Bodle; Spencer J. Carter; WIL Research, Ashland, OH
Pharmacokinetic Studies of a Novel Thiazolidinedione
mitoNEET Ligand, NL-1, Using a Quantitative LC-MS/
MS Method in Dosed Mouse Serum and Brain ; Kiran
Pedada1; Xiang Zhou1; Harini Jogiraju1; Richard Carroll2;
Werner Geldenhuys2; Li Lin2; David Anderson1; 1Cleveland
State University, Cleveland, OH; 2Northeast Ohio Medical
University, Rootstown, OH
Simultaneous LC-ESI-MSMS-MRM Quantification of
Glutathione and Six Related Compounds; Alexander
Yoon; Stephen Shew; Joseph Watson; Kym Faull;
University of California, Los Angeles, CA
Comprehensive LC/MRM Assay for Determination
of Nerve Agent Therapeutics in Guinea Pig Brain
Microdialysate and African Green Monkey Plasma;
Benjamin Oyler; Tsung-Ming Shih; John McDonough;
Benedict Capacio; USAMRICD, Aberdeen Proving Ground,
MD
Low-Level Quantitative Analysis of Prostaglandins in
Human Serum and Urine by LC/MS/MS Utilizing Dual
Ion Funnel Technology; Yanan Yang; Kevin McCann;
Anabel Fandino; Caroline Chu; Mark Sartain; Na Pi; Agilent
Technologies, Inc, Santa Clara, CA
Application of a Highly Sensitive LC/MS/MS Assay
for the Comparison of Exposure to Nicotine and
its Metabolites; Kimberly Clark; Joshua Prey; Richard
O’Connor; Mark Travers; Gerald Fetterly; Roswell Park
Cancer Institute, Buffalo, NY

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Determination of Urinary Catecholamines and
Metanephrines in a Single Run by LC/MS/MS for Clinical
Research; Linda Cote1; Christophe Deckers1; Kevin
McCann2; 1Agilent Technologies Canada, Saint-Laurent,
Canada; 2Agilent Technologies, Santa Clara, CA
Quick Sample Preparation of Opiates from Urine for
UHPLC/MS analysis; Daniel Tran; Agilent Technologies,
Lake Forest, Ca, CA
High Throughput, Simultaneous Analysis, Separation
and Validation of Eight Opioids and Metabolites in
Human Urine by LC-MS/MS; Jianmei Wang; Ramiro
Cavazos; Toqueer Rizvi; Texas Medical Toxicology,
Houston, Texas
Fast and Sensitive Assay of Tobacco Specific
Nitrosamines by UHPLC-MS/MS; Mikael Levi; Maureen
Ramero; Stéphane Moreau; Shimadzu France, Noisiel,
France
Quantifying Metformin in Mouse Serum Using
Hydrophilic Interaction Liquid Chromatography and
Stable Isotope Dilution-Assisted Multiple Reaction
Monitoring Mass Spectrometry (HILIC-SID-MRM-MS);
Da-Qing Yang; Mikel R. Roe; Michael E. Grossmann; Nancy
K. Mizuno; Adrian D. Hegeman; Margot P. Cleary; University
of Minnesota, Austin, MN
Small Molecule, Big Challenges: Development and
Validation for the Determination of Mesalamine and Its
Metabolite in Human Plasma by HILIC-MS/MS; Jingguo
Hou; Ravi Orugunty; Xiaodong Zhu; Melvin Tan; Thomas
Horvath; Jing Zhou; Gregory Poch; Michael Sullivan;
Edward Wells; Steve Unger; WWCT, Austin, TX
Development and Validation of a HILIC Based UPLCESI-MS/MS Method for the Quantification of Free
Carnitine in Human Plasma; Tiffany Thomas; Roseann
Zott; Danielle Awad; Dawn Hershman; Serge Cremers;
Columbia University, New York, NY
Quantitation of Glutathione and Related Thiols in
Acid-Preserved Samples by Hydrophilic Interaction
Chromatography-Mass Spectrometry; Alan W. Taylor;
Deborah Hobbs; Debbie J. Mustacich; Balz Frei; Linus
Pauling Institute, Oregon State University, Corvallis, OR
Simultaneous Quantification of Metanephrine,
Normetanephrine, Histamine, Serotonin, and
3,4-dihydroxyphenylglycol in Dog plasma by LC-MS/MS;
Aihua Liu; Troy Voelker; Min Meng; Tandem Labs, Salt Lake
City, UT
Development of an Analytical Method for Hydroxyurea
in Rat Plasma, Amniotic Fluid, and Fetus by HILIC-MS/
MS; Michael S. Gardner1; Melanie A. Rehder Silinski1;
Reshan A. Fernando1; Veronica G. Robinson2; Suramya
Waidyanatha2; 1RTI International, Research Triangle Park,
NC; 2Division of National Toxicology Program, NIEHS,
Research Triangle Park, NC
Determination of S-ketamine in Rat Plasma by a ShortRun LC-MS/MS Method; Qingtao (Mike) Huang1; Eric De
Waal1; Naidong Weng1; Weimin Wang2, 2; Chih Hsien Lin2, 2;
Hsiaoju Lin2; Zhongping (John) Lin2; Harry Zhao2; 1Johnson
& johnson, Raritan, NJ; 2Frontage Lab, Exton, PA
Validation of (R,S)-Enantiomers of Amphetamine in
Human Plasma by SOLA-CX LC/MS/MS API4000; Adlai
Niggebrugge; Laura Baum; Sarah Maasjo; Dan Pederson;
David O’Connor; Mario Pellerin; Ardeshir Khadang; PRACS
Institute, Fargo, ND
(S)-(+)-Vigabatrin Determination in Plasma by LC/
MS with Two Methods: Chiral Column Without
Derivatization and Non-Chiral Column with Pre-Column
Derivatization; Shan Jin; Eric Britton; Steven Wiltshire;
Agilux Laboratories, Worcester, MA

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Analysis for Hydroxylated Polybrominated Diphenyl
Ethers (OH-PBDEs); Yan-Ping Lin1; Louis Maljers2; Helen
Sun2; Isaac N. Pessah1; Birgit Puschner1; 1University of
California, Davis, CA; 2Bruker Daltonics Inc., Fremont, CA
Determination of Valproic Acid in Human Plasma Using
Derivatization and LC-MS/MS Techniques; Moo-Young
Kim; Anika Pippin; Yu-Hui Ann Fu; Yansheng Liu; KCAS,
Shawnee, KS
A Novel LC-MS/MS Method for the Ultra-Sensitive
Isolation and Detection of 1a,25(OH)2-Vitamin D3 and Its
Common Metabolites in Serum Samples; Adam Latawiec;
Michael Jarvis; AB SCIEX, Concord, Canada
Chemical Derivatization of d6-bisphenol A Increases
Sensitivity in Trace Level Serum Evaluations; Nathan
C. Twaddle; Mona I. Churchwell; Daniel R. Doerge; NCTR/
FDA, Jefferson, AR
Lipids: Quantitative Analysis, 478 – 497

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High-speed Monitoring Method for Eicosanoids and
Related Compounds Using Liquid Chromatography /
Mass Spectrometry; Masaki Yamada1, 2; Yoshihiro Kita1;
Suzumi Tokuoka1; Takahiro Kohira1, 3; Takao Shimizu1; 1The
University of Tokyo, Tokyo, Japan; 2Shimadzu Corporation,
Kyoto, Japan; 3Japanese Red Cross Society, Tokyo, Japan
Global Analysis of Lipidome of Caenorhabditis elegans
Based on Shotgun Lipidomics Strategy; Tanxi Cai 1;
Jiaojiao Ma1; Charles C. Liu2; Fuquan Yang1; 1Institute of
Biophysics, CAS, Beijing, China; 2ASPEC Technologies
Limited, Beijing, China
A Novel UHPLC-Q-TOF Method for the Detection and
Quantification of Plasma Lipids; Carlos Leon; William
Wikoff; Tomas Cajka; Brian DeFelice; Dmitry Grapov; Oliver
Fiehn; UC Davis, Davis, CA
Differential Quantitation of TAG Isomers by
Mathematical Modeling of Neutral Losses Of Fatty
Acids; Haowei Song; Jack Ladenson; Fongfu Hsu; John
Turk; Washington University in St. Louis, School of Medi, St.
Louis, MO
Quantitative Analysis of Sulfatides in Mouse Plasma
Membrane Using UHPLC-MS-MS; Guannan Li1; Ana Lis
Moyano2; Jan-Eric Mansson3; Maria Irene Givogri2; Richard
B. van Breemen1; 1University of Illinois College of Pharmacy,
Chicago, IL; 2University of Illinois College of Medicine,
Chicago, IL; 3University of Gothenburg The Sahlgrenska
Academy, Gothenburg, Sweden
Quantitative Targeted Lipidomics in Urine:
Phosphatidylserine by UPLC-MS/MS; Sabrina Forni;
Lawrence Sweetman; Baylor Research Institute, Dallas, TX
Lipids Analysis in 9 Seconds Sample to Sample
with Surface Improved Plates and Vaporization
Enhancement Solution in LDTD-MS/MS; Pierre Picard1;
Gregory Blachon1; Serge Auger1; Réal Paquin2; 1Phytronix
Technologies, Quebec city, Canada; 2Université Laval,
Quebec City, Canada
Comprehensive Lipid Profiling of Drosophila
melanogaster (fruit fly) under Diverse Starvation
Conditions Using Metabolic 13C Isotope Labeling;
Vinzenz Hofferek; Max-Planck-Institute, Potsdam-Golm,
Germany
Shotgun Lipidomics Analysis of Diacylglycerol Species
in Biological Samples after One-step Derivatization;
Miao Wang; Huafeng Fang; Jacina Redden; Xianlin Han;
Sanford-Burnham Medical Research Institute, Orlando, FL

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Trimethylation Enhancement using Diazomethane
(TrEnDi): Rapid Methylation of Phospholipids to Permit
Quantitative Analysis Using Tandem Mass Spectrometry;
Karl Wasslen; Hyunmin Lee; Jeffrey Manthorpe; Jeffrey C.
Smith; Carleton University, Ottawa, Canada
Formation and the Use of [M+42] - Ion for the
Identification and Quantitation of sphingosine-1phosphate and Its Analogs after bis-Acetylation; Irina
Gorshkova; Evgeny Berdyshev; University of Illinois at
Chicago, Chicago, IL
LC-MS and MALDI-TOF Characterization of Glycolipidbearing Liposomes; Spiros Manolakos1, 2; Theresa EvansNguyen1, 2; Leila Albers1, 2; James Comolli1, 2; 1The Charles
Stark Draper Laboratory, Tampa, FL; 2The Charles Stark
Draper Laboratory, Cambridge, MA
A Rapid Serum Free Fatty Acids Profiling by MALDIFTICR MS; Yaping Zhang; Yujie Liu; Shuai Guo; Hui Liu;
Fenjie Li; Zhili Li; IBMS, CAMS&PUMC, Beijing, China
Profiling Biochemical Effects of Osteopathic
Manipulative Treatment on COPD Patients: Multi-Class
Determination of Bioactive Lipids in Plasma Samples;
Chen Zhang; Michigan State University, East Lansing, MI
Rapid Profiling of Oxylipins for Drug
Discovery&Development, Nutritional and Clinical
Research; Roy Martin1; Katrin Strassburg2, 3; Thomas
Hankemeier3; Giorgis Isaac1; James Langridge1; Claude
Mallet1; Rob Vreeken2, 3; Giuseppe Astarita1; 1Waters
Corporation, Milford, MA; 2Netherlands Metabolomics
Centre, Leiden, The Netherlands; 3Analytical BioSciences,
LACDR, Leiden, The Netherlands
Hydroxylated Metabolites of Docosahexaenoic
Acid are Substrates for 15-Hydroxyprostaglandin
Dehydrogenase (15-PGDH): Electrophile Formation and
Anti-inflammatory Signaling Actions; Stacy L. Gelhaus;
Franca Golin-Bisello; Sally Wenzel; Fernando Holguin;
Bruce A. Freeman; School of Medicine, University of
Pittsburgh, Pittsburgh, PA
Combined Proteomics and Lipidomics Analyses
Enable the Characterization of Phagosome Maturation
in Activated Macrophages; Christina Bell1; Guanghou
Shui2; Markus Wenk2; Michel Desjardins1; Pierre Thibault1;
1
University of Montreal, Montreal, Canada; 2National
University of Singapore, Singapore
Quantification of Lipids in Human Cancer Cells and
Culture Supernatants by LC-MS/MS; Finnur Eiriksson2;
Baldur Sigurdsson2; Sesselja Omarsdottir1; Kari Skulason1;
Helga Ogmundsdottir1; Margret Thorsteinsdottir1, 2;
1
University of Iceland, Reykjavik, Iceland; 2ArcticMass,
Reykjavik, Iceland
Identification of Lipid Bio-Markers for Dry Eye
Disease in Post-Menopausal Women Using Shotgun
Electrospray Mass Spectrometry; Mark Apsega1;
Jianzhong Chen1; Kelly Nichols2; Jason J. Nichols2; Kari
B. Green1; 1The Ohio State Universtiy, Columbus, OH;
2
Universtiy of Houston, Houston, TX
Phosphatidylserine Effects on Platelet-Activating
Factor Secretion from Platelets; Audrey Meyer; Secil
Koseoglu; Yiwen Wang; Joseph Dalluge; Christy Haynes;
University of Minnesota, Minneapolis, MN
Informatics: Quantification/Validation, 498 – 528

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Evaluation of Different Computational Algorithms for
Label-Free Protein Quantitation by Mass Spectrometry;
Francesco Mattia Mancuso; Cristina Chiva; Mireia Ortega;
Eduard Sabidó; Proteomics Unit, CRG/UPF, Barcelona,
Spain

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Integration of mProphet Chromatogram Peak
Identification Probability Model into Skyline; Brendan
Maclean1; Don Marsh1; Hannes Röst2; Lucia Espona
Pernas2; George Rosenberger2; Ruedi Aebersold2; Michael
MacCoss1; 1Univ of Washington, Seattle, WA; 2Institute of
Molecular Systems Biology, ETH Zurich, Zurich, Switzerland
The Use of QCONCAT Labeled Peptides to Validate
Label-Free Antigen Quantitation for Influenza Vaccines;
Daryl G.S. Smith; Genevieve Gingras; Yves Aubin; Terry D.
Cyr; Health Canada, Ottawa, Canada
PRiMe: Open Source Software for Visualization and
Quantitation of Large Scale Targeted Proteomics Using
Parallel Reaction Monitoring; Michael R. Hoopmann;
Samuel L. Bader; Robert L. Moritz; Institute for Systems
Biology, Seattle, WA
Tandem MS Epigenetics histones Analysis: A Novel
Medium Throughput Approach for Identification,
Labeled Quantification and Exploration; Alexandre
Masselot; Tobias Maile; Victoria Pham; Anita IzraelTomasevic; Robert Yauch; David Arnott; Genentech Inc.,
South San Francisco, CA
X-Quant: A Transplantable Tool for Label-Free
Quantification of Proteomics Based on MS/MS; Bo
Wen1; Haiyi Zhao1; Guilin Li1; Qiang Feng1; Quanhui Wang1,
2
; Siqi Liu1, 2; Jun Wang1; 1BGI-Shenzhen, Shenzhen, China;
2
Beijing Institute of Genomics, CAS, Beijing, China
iPiG: Proteogenomic Data Integration in Genome
Browsers; Mathias Kuhring; Bernhard Renard; Robert
Koch-Institute, Berlin, Germany
MRM Protein Quantification and Serum Sample
Classification; Pascal Szacherski1; Laurent Gerfault1;
Jean-François Giovannelli2; Audrey Giremus2; Pierre Mahé3,
4
; Tanguy Fortin3, 4; Geneviève Choquet-Kastylevsky3, 4;
Amna Klich5; Catherine Mercier5; Pascal Roy5; Arnaud
Salvador6; Jérôme Lemoine6; Jean-Philippe Charrier3, 4;
Bruno Lacroix3, 4; Pierre Grangeat1; 1CEA Leti, MINATEC
Campus, Grenoble, France; 2Univ. Bordeaux, IMS, UMR
5218, Talence, France; 3bioMérieux, Grenoble, France;
4
bioMérieux, Marcy l’Etoile, France; 5HCL, Service de
Biostatistique, Univ. Lyon I, CNRS, Lyon, France; 6Institut
des Sciences Analytiques,CNRS, Univ. Lyon, Lyon, France
Collisional Ion Trap Simulator (CITSIM) for Trajectory
Computation for Unsteady Flow Conditions Ranging
from Vacuum to Atmospheric Pressure; Sorin Mitran;
Bruno Coupier; J. Michael Ramsey; University of North
Carolina, Chapel Hill, NC
Detection and Correction of Interference in MS1
Quantitation of Peptides Using their Isotope
Distributions; Yifei Bao2; Jessica Chapman1; Joseph
Glavy2; Beatrix Ueberheide1; Manor Askenazi3; David
Fenyo1; 1New York University Langone Medical Center, New
York, NY; 2Stevens Institute of Technology, Hoboken, NJ;
3
The Ionomix Initiative, Arlington, MA
Accurate Multiplexed Proteomics at the MS2-Level
Using the Complement Reporter Ion Cluster; Martin
Wühr; Wilhelm Haas; Graeme C. McAlister; Leonid Peshkin;
Ramin Rad; Marc W. Kirschner; Steven P. Gygi; Harvard
Medical School, Boston, MA
Protein Cluster Identification and Quantitation with
Scaffold; Caleb J. Emmons; Brian C. Searle; Proteome
Software, Portland, OR
Deconvolution of Overlapping Peptide Isotopic
Peak Clusters with EM Algorithm for Label-free
Quantification; Lei Xin 1; M. Ziaur Rahman1; Weiwu Chen1;
Bin Ma2; 1Bioinformatics Solutions Inc., Waterloo, Canada;
2
University of Waterloo, Waterloo, Ontario

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INFORMATION
TUESDAY
POSTERS

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RIPPER: A New Software Framework for Biomarker
Discovery Using the Proportionality Paradigm and
Proximity-based Intensity Normalization (PIN); Susan
K. Van Riper1; Kathryn J. Doroschak2; Ebbing P. de Jong2;
LeeAnn Higgins2; Nelson L. Rhodus2; Frank G. Ondrey2;
John V. Carlis2; Timothy J. Griffin2; 1University of Minnesota
Rochester, Rochester, MN; 2University of Minnesota,
Minneapolis, MN
An Instrument Independent Demultiplexing Method
for Computationally Improving the Specificity of
Data Independent Acquisition; Dario Amodei1; Jarrett
Egertson2; Brendan McLean2; Richard Johnson2; Olga
Vitek3; Michael MacCoss2; Parag Mallick1; 1Stanford
University, Palo Alto, CA; 2University of Washington, Seattle,
WA; 3Purdue University, West Lafayette, IN
New Algorithm Utilizing All Ions MS/MS Data on TOF/QTOF and Accurate Mass MS/MS Libraries for Rapid
Development of Quant/Qual Methods; Frank Kuhlmann;
Stephen Madden; Bernhard Wuest; Maithilee Samant; Hong
Chen; Prerana Kapase; Agilent Technologies, Santa Clara, CA
Automated Quantification and Analysis of SILAC-iTRAQ
Dual-labeled Data; Getiria Onsongo; John Chilton; Michelle
Henderson; Timothy J. Griffin; Pratik Jagtap; Edgar Arriaga;
University of Minnesota, Minneapolis, MN
Refinements to Label-free Proteome Quantitation:
Applying Spectral Counting Strategies to Parent Ion
and Fragment Ion Intensities and Chromatographic
Peak Area; Ying Zhang; Zhihui Wen; Michael Washburn;
Laurence Florens; The Stowers Institute for Medical
Research, Kansas City, MO
Label-Free Inter-Sample Replicate Similarity Metrics
for LC-MS Data Using Intra-Sample Information; Rob
Smith; Dan Ventura; John Prince; Brigham Young University,
Provo, UT
A Simplified Method Development Interface for Routine
Quantification Applications on High-Resolution,
Accurate Mass Instrumentation; David Brant1; Catharina
Crone2; Tim Stratton1; Nick Duczak1; Patrick Bennett1;
1
Thermo Fisher Scientific, San Jose, CA; 2Thermo Fisher
Scientific GmbH, Bremen, Germany
ProDIA-id: An Automatic Tool to Extract MS/MS Spectra
for Protein Identification in Proteomic Experiments
Using Data-Independent Acquisition; Hui-Yin Chang1;
Nai-Yuan Chiang1; Chia-Feng Tsai2; Ya-Wen Tsai2; KeShiuan Lynn1; Chia-Ying Cheng1; Yu-Ju Chen2; Ting-Yi
Sung1; Wen-Lian Hsu1; 1Institute of Information Science,
Academia Sinica, Taipei, Taiwan; 2Institute of Chemistry,
Academia Sinica, Taipei, Taiwan
A Qualitative and Quantitative Ion Mobility Enabled Data
Independent SILAC Workflow; Andrew JK Williamson1;
Steven Ciavarini2; Scott J Geromanos2; Andrew Tudor3;
Barry Dyson3; Lee Gethings3; Kelly McMahon3; Robert
Tonge3; James I Langridge3; Anthony D Whetton1; Johannes
PC Vissers3; 1School of Cancer and Imaging Sciences,
Manchester, UK; 2Waters Corporation US, Milford, MA;
3
Waters Corporation UK, Manchester, UK
Critical Assessment of Proteome-Wide Label-Free
Absolute Quantification Strategies; Erik Ahrné; Timo
Glatter; Lars Molzahn; Alexander Schmidt; Proteomics Core
Facility, Biozentrum, Basel, Switzerland
MS1Probe – Implementation of a Statistical Tool for
MS1-based Quantitation in Skyline for High Throughput
Quantitative Analysis; Alexandria K. D’Souza1; Birgit
Schilling1; Julian Chytrowski1; Brendan MacLean2; Daniel
Broudy2; Nicholas J. Shulman2; Michael J. MacCoss2;
Bradford W. Gibson1; 1Buck Institute for Research on Aging,
Novato, CA; 2University of Washington, Seattle, Seattle, WA

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Validation of Label-Free Methods for Protein
Quantitation and Their Application to the
Characterization of the Exon Junction Complex; John
Leszyk; Guramrit Singh; Melissa J. Moore; Scott A. Shaffer;
University of Massachusetts Medical School, Worcester, MA
THOR: an Algorithm for Determining the Variance Cutoff
In Proteomics Count Data; Scott Walmsley1; Damian
Fermin1; Hyungwon Choi2; Alexey Nesvizhskii1; 1University
of Michigan Department of Pathology, Ann Arbor, MI;
2
National University of Singapore, Singapore, Singapore
Automatic Reprocessing, Analysis and Reporting in
High-Throughput Analytical Environments; Manuel
Perez Pacheco1; Carlos Cobas1; Felipe Seoane1; Santiago
Dominguez1; Mike Bernstein1; Chen Peng1; Agustin Barba1;
George Maydwell2; Scott Campbell2; 1Mestrelab Research,
Santiago De Compostela, Spain; 2Sierra Analytics, Modesto,
CA
New Functionality for the Trans-Proteomic Pipeline:
Tools for the Analysis of Proteomics Data; Luis
Mendoza1; David Shteynberg1; Joseph Slagel1; Michael
Hoopmann1; Terry Farrah1; Zhi Sun1; Brian Pratt2; Henry
Lam3; Jimmy K. Eng4; Alexey I. Nesvizhskii5; Eric W.
Deutsch1; Robert L. Moritz1; 1Institute For Systems Biology,
Seattle, WA; 2Insilicos, LLC, Seattle, WA; 3Hong Kong
University of Science and Technology, Clear Water Bay,
Hong Kong; 4University of Washington, Seattle, WA;
5
University of Michigan, Ann Arbor, MI
Capturing Multi-Dimensional Proteomes in an Online
Encyclopedia; Yasmeen Ahmad; Mark Larance; Tony Ly;
Kathryn Kirkwood; Dalila Bensaddek; Armel Nicolas; Angus
I. Lamond; Centre for Gene Regulation & Expression,
University of Dundee, UK
MZDASoft™ Parallel Peak Extractor™: A Software Tool
for LC/MS data Integration and Compression; Nelson
Ramirez; Zhiwei Wang; David M. Noriega; Yung Lai; Jianqiu
(Michelle) Zhang; UTSA, San Antonio, TX
Graph-based Time Alignment Algorithms for LC-MS
Datasets with Large Retention-Time Drifts; Jijie Wang;
Henry H. N. LAM; The Hong Kong University of Science and
Technology, Clear Water Bay, Kowloon, Hong Kong, China
Toxicology, 529 – 556

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High-Throughput Cotinine Determination in Human
Plasma, Urine and Saliva Using LDTD-MS/MS in 8
Seconds Sample to Sample; Sylvain Letarte1; Gregory
Blachon1; Serge Auger1; Pierre Picard1; Sarah Demers2;
1
Phytronix Technologies, Québec, Canada; 2Université
Laval, Québec, Canada
Cadmium Exposure Results in the Up-regulation of
DDAH I&II in Human Fibroblast Cells as Revealed by
SILAC-based Quantitative Proteomics; John Prins;
Yinsheng Wang; University of California, Riverside, CA
Stable Isotope Dilution NanoLC-Nanospray Ionization
Tandem Mass Spectrometry Analysis of Three Ethylated
Thymidine Adducts in Human Salivary DNA; Hauh-Jyun
Candy Chen; Chin-Ron Lee; National Chung Cheng Univ.,
Ming-Hsiung, Chia-Yi, Taiwan
High Throughput Liquid ChromatographyTandem MassSpectrometry Method for Analysis of
4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol(NNAL)
and its Glucuronides in Human Urine; Steven Carmella;
Xun Ming; Andrea Yoder; Elizabeth Vielguth; Stephen S.
Hecht; Univ. of Minnesota Cancer Center, Minneapolis, MN
Liquid Chromatography-Tandem Mass Spectrometry
Quantitationof DNA Adducts in Tissues of Rats Treated
Chronically with Enantiomers of the Carcinogen N’Nitrosonornicotine; Lijiao Zhao; Silvia Balbo; Mingyao

61ST ASMS CONFERENCE ON MASS SPECTROMETRY

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Wang; Peter Villalta; Pramod Upadhyaya; Stephen S.
Hecht; Univ. of Minnesota Cancer Center, Minneapolis, MN
Toxicological Analysis of Whole Blood Samples Using
Automated SPE/HPLC/MS/MS; Ken Lewis1; Robert
Sears2; Kim Gamble3; 1OpAns, LLC, Durham, NC; 2South
Carolina Law Enforcement Division, Columbia, SC; 3ITSP
Solutions, Hartwell, GA
Comprehensive Toxicological Screening Using Generic
MS/MSALL Acquisition on a Q-TOF Tandem Mass
Spectrometer; Michael J. Y. Jarvis; Jesse Seegmiller;
Jenny Moshin; Adrian Taylor; AB SCIEX, Concord, Canada
Automated Direct Sample Analysis (DSA/TOF) for
the Rapid Screening and Confirmation of Illicit Street
Drugs; Sean Daugherty1; Alun Hucthings2; Mark Upton1;
1
PerkinElmer, Bucks, UK; 2Cardiff Tox Lab, University
Hospital Llandough, Cardiff, Wales
Detection and Metabolic Characterization of the
Hallucinogenic Compound 25I-NBOMe in Biological
Samples via LC-MS; David Le1; An Nguyen1; Samuel J
Stellpflug2; Gregory Janis1; 1MedTox Laboratories, New
Brighton, MN; 2Regions Hospital Dept. of Emergency
Medicine, Saint Paul, MN
Chiral Separation and Quantification of
Methamphetamine Stereoisomers by Capillary
Electrophoresis/Triple Quadrupole Mass Spectrometry;
Flaubert Mbeunkui; Steven Cohen; Joseph Wiegel; Brent
Dixon; Physicians Choice Laboratory Services, Charlotte, NC
A Mixed Targeted and Untargeted LC-TOF Approach
for Monitoring Emerging Drugs of Abuse in Biological
Samples; An Nguyen; Gregory Janis; MedTox Laboratories,
New Brighton, MN
Qualitative and Quantitative Analysis of Illicit Drugs
in Biological Fluids by Turbulent-Flow LC Coupled to
an Exactive benchtop Orbitrap MS; Jérémy Pinguet1,
2
; Lucie Roche1; Pauline Herviou1; Damien Richard1, 2;
1
CHU Clermont Ferrand, Clermont Ferrand, France; 2UMR
INSERM 1107 Neurodol, Université d’Auvergne, Clermont
ferrand, France
Determination of Barbiturates and 11-nor-9-carboxyΔ9-THC in Urine Using Automated Disposable Pipette
Extraction (DPX) and LC/MS/MS; Oscar G. Cabrices; Fred
Foster; Edward Pfannkoch; Gerstel Inc., Linthicum, MD
Development of an LC-NSI-HRMS/MS-PRM Method for
Quantification of Attomole Levels of 7-Phenyl-Guanine
to Determine the Mechanism of Benzene-Induced
Cancer; Adam Zarth; Silvia Balbo; Guang Cheng; Stephen
Hecht; University of Minnesota, Minneapolis, MN
Selective Inhibition of Cytochrome P450 Isoform of
Hyperoside: Potent Effect on CYP2D6; Oh Kwang Kwon;
Miri Hong; Min Song; Sunju Kim; Ju Hee Sim; Jong-Sup
Bae; Sangkyu Lee; Kyungpook National University, Daegu,
Korea
Pain Management Drug Monitoring in Urine Using
HPLC/MS-MS; Jill Wolken; Thomas Doran; Paula Smith;
Anita Iwanski; Don Wiebe; University of Wisconsin Hospital
and Clinics, Madison, WI
An Improved Immunosuppressant Drug Research
Method based on a Novel SPLC-MS/MS System; Joseph
Di Bussolo; Christopher Esposito; Francois Espourteille;
Thermo Fisher Scientific, Franklin, MA
Comprehensive Clinical Toxicology Screening by a
Novel Ion Trap MSn Workflow; Markus Meyer1; Christoph
Gebhardt1; Birgit Schneider1; Sebastian Götz1; Laura M.
Huppertz2; Susanne Vogt2; Jürgen Kempf2; 1Bruker Daltonik,
Bremen, Germany; 2Institute of Legal Medicine, University
Freiburg, Freiburg, Germany

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High Throughput Analysis of the Polycyclic
AromaticHydrocarbon Metabolite Phenanthrene Tetraol
in Human Urine by Gas Chromatography-TandemMass
Spectrometry; Natalie Olvera; Claire Brookmeyer; Steven
Carmella; Stephen S. Hecht; Univ. of Minnesota Cancer
Center, Minneapolis, MN
devTOX quickPredict: A Rapid LC-MS-Based Metabolite
Biomarker Assay to Predict Developmental Toxicity
Using Human Cells; Paul R. West; Egnash Laura; Alan
Smith; Jessica Palmer; Kevin Conard; Mark Ross; Burr
Fontaine; Preeti Bais; Elizabeth Donley; Robert Burrier;
Stemina Biomarker Discovery, Madison, WI
Aristolactam N-sulfate: A Highly Reactive Metabolite
of Aristolochic Acid; Irina Zaitseva; Viktoriya Siderenko;
Sivaprasad Attaluri; Francis Johnson; Arthur P. Grollman;
Charles R. Iden; Stony Brook University, Stony Brook, NY
Analysis of All Citric Acid Cycle Metabolites by Liquid
Chromatography – Tandem Mass Spectrometry; Andrew
J. Worth; Sankha Basu; Clementina Mesaros; Nathaniel
W. Snyder; Ian A. Blair; University of Pennsylvania,
Philadelphia, PA
Rapid Determination of Tramadol and N-desmethyl
Tramadol in Human Urine by HPLC-MS-MS Optimized
Method; Mehdi Jalali; Pacific Toxicology Laboratory,
Chatsworth, CA
Transformation of Aflatoxin B1 in Soil; Mustafa Selim1;
James Starr2; 1East Carolina University, Greenville, NC;
2
U.S. Environmental Protection Agency, Research Triangle
Park, NC
DNA Adductomics Methodology Utilizing a High
Resolution Accurate Mass MSn Approach for Analysis
of Human DNA Samples; Peter Villalta; Silvia Balbo;
Pramod Upadhyaya; Stephen Hecht; University of
Minnesota, Minneapolis, MN
USP<467>: Benefits of Use Headspace GCMassSpectrometry System; Daniele Recenti1; Roberta
Lariccia1; Ilaria Ferrante1; Luigi Motti2; 1DANI, Cologno
Monzese, Italy; 2Dani SA, Contone, Switzerland
Automated Sample Preparation for Toxicology
Screenings Workflows on Linear Ion Trap Instruments;
Adrian Taylor1; Michael Jarvis1; Jesse Seegmiller1; Oscar
Cabrices2; 1AB SCIEX, Concord, Canada; 2GERSTEL, Inc.,
Linthicum, MD
Evaluation of Mitochondrial Function Based on
the Direct Single-Cell Molecular Analysis by Mass
Spectrometry; Sachiko Date1; Kiyoko Bando2; Jiro
Deguchi2; Izuru Miyawaki2; Juki Kimura2; Hitoshi
Funabashi2; Tsutomu Masujima1; 1Quantitative Biology
Center (QBiC), Riken, Osaka, Japan; 2Dainippon Sumitomo
Pharma Co., Ltd., Osaka, Japan

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Measurement of Thiopurine Metabolites as a
Companion Diagnostic Test to the Genotypic and
Phenotypic Thiopurine Methyltransferase Assays; Stacy
Dee; Yvonne Wright; Russell Grant; LabCorp, Burlington,
NC
Improved UPLC Tandem Mass Spectrometry Assay for
Uridine Diphosphate Galctose-4-epimerase Deficiency;
Jie Chen1; Gail A Ditewig Meyers1; Michael J Bennett1,
2 1
; Children’s Hospital of Philadelphia, Philadelphia, PA;
2
University of Pennsylvania, Philadelphia, PA
Determination of 3-Epi-25-hydroxyvitamin D2 in Human
Serum Using Liquid Chromatography-Tandem Mass
Spectrometry; Susan Tai; NIST, Gaithersburg, MD

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TUESDAY
POSTERS

TP 560

TP 561

TP 562

TP 563

TP 564

TP 565
TP 566

TP 567

TP 568

TP 569

TP 570

TP 571

TP 572

Development of an Improved Standard Reference
Material for Vitamin D Metabolites in Serum; Karen
Phinney; Mary Bedner; Susan Tai; Lane Sander; Katherine
Sharpless; Stephen Wise; National Institute of Standards
and Technology, Gaithersburg, MD
Results from the Initial Comparability Studies of the
NIST/NIH Vitamin D Metabolites Quality Assurance
Program; Mary Bedner; Katrice Lippa; Susan Tai; NIST,
Gaithersburg, MD
Reducing Systematic Errors in the LC-MS/MS
Determination of Vitamin D; Dietrich Volmer; Julia
Aspenleiter; Saarland University, Saarbrücken, Germany
A Novel Method for the Extraction of 1α, 25-dihydroxyVitamin D2/D3 and Analysis Using UHPLC-MS/MS; Alan
Edgington1; Lee Williams1; Rhys Jones1; Adam Senior1;
Helen Lodder1; Geoff Davies1; Steve Jordan1; Gavin Jones1;
Claire Desbrow1; Victor Vandell2; Frank Kero2; 1Biotage GB
Limited, Cardiff, UK; 2Biotage, Charlotte, NC
The Determination of Optimum Centrifugation
Parameters when Designing a Robust and Sensitive
25OH-Vitamin D Assay using UPLC/MS; Maria Cid; Stuart
Coleman; New York Presbyterian Hospital, New York, NY
The Search for 3-Epi-25 Hydroxy Vitamin D; Jonathan
Tang; William Fraser; University of East Anglia, Norwich, UK
Simple, Accurate Quantitation of Nicotinic Acid and
Nicotinamide in Human Plasma by Rapid Protein
Precipitation Using HPLC-MS/MS; Shuguang Li; Erica
Pike; Phenomenex, Torrance, CA
Evaluation of Acylcarnitines with Dicarboxylic Acid
Residues as Candidate Markers for Neurodegenerative
Syndromes; Andrea Raffaelli1; Riccardo Donzelli2;
Alessandro Saba3; Adriano Carpita2; Gabriele Siciliano3;
1
CNR ICCOM - UOS Pisa, Pisa, Italy; 2University of Pisa,
Department of Chemistry, Pisa, Italy; 3University of Pisa,
Department of Medicine, Pisa, Italy
Challenges in the Conversion of a Multianalyte GCMS Method to a High-Throughput LC-MS/MS Clinical
Diagnostic Assay; Lisa Ford; Qibo Zhang; Carolyn
Sheffield; Jonathan McDunn; Robert Wolfert; Metabolon,
Research Triangle Park, NC
Simultaneous and Fast Analysis of Amino Acids,
Acylcarnitines and Orotic Acid in Dried Blood Spots by
Triple Quadrupole LC-MS/MS; Scott Kuzdzal1; Hironori
Kobayashi2; Toshikazu Minohata3; Yuki Hasegawa2; Ichiro
Hirano3; Seiji Yamaguchi2; 1Shimadzu Scientific Instruments,
Inc., Columbia, MD; 2Shimane University Faculty of
Medicine, Izumo, Japan; 3Shimadzu Corporation, Kyoto,
Japan
Analysis of Dried Blood Spot Samples by High
Resolution Mass Spectrometry – Validation of a Novel
Method for Newborn Screening; Julia Denes1; Steven L.
Robinette1; Eszter Szabo2; Ildiko Szatmari2; Laszlo Szonyi2;
Ernst W. Rauterberg3; Zoltan Takats1; 1Imperial College
London, London, UK; 21st Dept. of Pediatrics, Semmelweis
University, Budapest, Hungary; 3Hesse Child Health Centre,
Giessen, Germany
Determination of Desmosterol, Campesterol,
Cholestanol, and β-sitosterol in Plasma Utilizing LCMS/MS Technology in Clinical Diagnostics; Jim Bruton;
Joseph McConnell; Daniel Hoefner; Tara Dall; Thomas
Dayspring; Health Diagnostic Laboratory, Richmond, VA
Characterizing Blood Bile Alcohols in Cerebrotendinous
Xanthomatosis (CTX); Promising Disease Markers
Detectable in a Dried Bloodspot LC-ESI-MS/MS Test for
CTX; Andrea E DeBarber; Robert D Steiner; Oregon Health
& Science University, Portland, OR

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TP 575

TP 576

TP 577

Simplified Extraction of 3 Steroids from Biological Fluid
for LC-MS/MS Analysis; Silvia Bächer1; Michael Vogeser1;
Christine Lehmann2; Robert Wohleb2; Roland Geyer2;
1
Clinical Chemistry, University Hospital Munich, Munich,
Germany; 2Tecan Schweiz AG, Männedorf, Switzerland
Performance of the AbsoluteIDQ® Stero17 Kit on
ABSciex, Waters and Thermo Scientific Triplequad Mass
Spectrometers for Steroid Hormones Analysis; Hai
Pham Tuan; Doreen Kirchberg; Therese Koal; BIOCRATES
Life Sciences, Innsbruck, Austria
Quantification of Immunosuppressants by LC-MS/
MS Ion Trap Analysis with a New Smart MRM Mode
and Compound Verification by Library Search; Andrea
Kiehne; Birgit Schneider; Markus Peer; Markus Meyer;
Bruker Daltonik GmbH, Bremen, Germany
Cross Validation between LDTD-MS/MS and LC-MS/MS
for the Determination of 4 Immunosuppressant Drugs in
Whole Blood; Gregory Blachon1; Kamisha Johnson-Davis2;
Jean Lacoursiere1; Pierre Picard1; Serge Auger1; Annick
Dion-Fortier1; 1Phytronix Technologies, Québec, Canada;
2
ARUP Laboratories, Salt Lake City, UT
High-Throughput Determination of 25-OH-Vitamin D2
and D3 in Plasma Using LDTD-MS/MS with Differential
Mobility Spectrometry in 9 seconds Per Sample; Alex
Birsan1; Pierre Picard1; Gregory Blachon1; Michael Jarvis2;
Serge Auger1; Adrian Taylor2; Jean Lacoursière1; 1Phytronix
Technologies Inc., Quebec, Canada; 2AB SCIEX, Concord,
Canada
Environmental Analysis:
Pharmaceuticals and Pesticides, 578 – 607

TP 578

TP 579

TP 580

TP 581

TP 582

TP 583

A Strategy for an automated Unknown Screening
Approach on Environmental Samples Using HRAM
Mass Spectrometry; Olaf Scheibner1, 3; Maciej Bromirski1,
3
; Patricia van Baar2; Florian Wode2; Uwe Dünnbier2; Kristi
Akervik1, 3; Jamie Humphries1, 3; 1Thermo Fisher Scientific,
Bremen, Germany; 2Berliner Wasserbetriebe, Berlin,
Germany; 3Thermo Fisher Scientific, Austin, TX
Screening Environmental Samples for a Diverse Range
of Compound Classes/Structures with Accurate Mass
LC-MS and an Integrated Scientific Information System;
Gareth Cleland; Lauren Mullin; Claude Mallet; Jennifer
Burgess; Waters Corporation, Milford, MA
Ultra-sensitive Detection of Pharmaceutical and
Personal Care Products (PPCP’s) in Water with an
Integrated On-Line Extraction (OLE)-UHPLC-MS/MS
System; Zicheng Yang; Helen Sun; Kefei Wang; Bruker,
Fremont, CA
Determination of Pharmaceuticals by Direct Aqueous
Injection-HPLC/MS/MS in Source and Drinking Waters
from 25 Municipal Treatment Plants; Edward T. Furlong1;
Mary C. Noriega1; Susan T. Glassmeyer2; Dana W. Kolpin3;
1
National Water Quality Lab, U.S. Geological Survey,
Denver, CO; 2U.S. Environmental Protection Agency,
Cincinnati, OH; 3U.S. Geological Survey, Iowa City, IA
Determination of Pharmaceutical Compounds from
Drinking and Surface Water at Low ng/L Levels Using
Direct Aqueous Injection Triggered MRM LC-QQQ-MS;
László Toelgyesi1; Andreas Wanke2; Thomas Glauner1;
Susanne Soelter1; 1Agilent Technologies, Waldbronn,
Germany; 2SMUL Sachsen, Nossen, Germany
Degradation Processes of Environmentally Relevant
Pharmaceuticals; Linyan Zhu1, 2; Beatrix SantiagoSchuebel1; Agnieszka Kraj3; Zhiliang Zhu2; Yanling Qiu2;
Stephan Kueppers1; 1Research Center Jülich, ZEA-3, Jülich,
Germany; 2Tongji University, Shanghai, China; 3Antec,
Zoeterwoude, The Netherlands

61ST ASMS CONFERENCE ON MASS SPECTROMETRY

TUESDAY POSTERS

TP 584

TP 585

TP 586

TP 587

TP 588

TP 589

TP 590

TP 591

TP 592

TP 593

TP 594

Natural Attenuation of Emerging Contaminants in
the Critical Zone: Time of Flight Mass Spectrometry
Measurement Approaches; Rachel Maxwell1; Leif Abrell1;
Andrea Conine2; Shane Snyder1; Jon Chorover1; 1University
of Arizona, Tucson, AZ; 2Skidmore College, Saratoga
Springs, NY
LC-MS/MS for Screening and Quantifying Anti-Cancer
Drugs and Metabolites in Waste Water Rejected in
Mediterranean Sea; Thérèse Schembri1; Mikael Levi2;
François Gray1; Stéphane Moreau2; Claude Villard1; Pierre
Boissery3; Daniel Lafitte1; 1Aix Marseille Université, Inserm
UMR 911 CRO2, Marseille, France; 2Shimadzu France,
Noisiel, France; 3Agence de l’Eau Rhône Méditerranée &
Corse, Marseille, France
Determinaiton of Non-Steroidal Anti-Inflammatory
Drugs in Environmental Water by Dispersive
Liquid-Liquid Microextraction Coupled with Liquid
Chromatography-Tandem Mass Spectrometry; ShihShan Tai; Chung-Yu Chen; Maw-Rong Lee; National ChungHsing University, Taichung, Taiwan
Removal of Matrix Effects Using Ion-Exchange SPE
during Analysis of veterinary Antibiotics Present
in Manure by LDTD-APCI-MS/MS; Morgan Solliec1, 2;
Daniel Massé2; Sébastien Sauvé1; 1Université de Montréal,
Montréal, Canada; 2Agriculture and Agri-Food Canada,
Sherbrooke, Canada
Identification and Structural Elucidation of Ozonation
Transformation Products of Emerging Contaminants;
Pedro A. Segura; Angela Rodayan; Pearl Kaplan; Karim
Saadi; Rachel Benoît; Viviane Yargeau; McGill University,
Montréal, Canada
Routine, Targeted and Non-Targeted Analysis of
Environmental Contaminants of Emerging Concern –
Development and Validation of a UHPLC-Orbitrap MS
Method; Paul Yang1; Tung Vi Nguyen2; Vince Pileggi1;
Kristi Akervik3; Chunyan Hao1; Xiaoming Zhao1; Serei
Thach1; Jennifer Newman1; Yafang Lu1; Sonya Kleywegt1;
Shahram Tabe1; Ramin Farnood2; Charles Yang3; Jonathan
Beck3; Maciej Bromirski3; Dipankar Ghosh3; 1Ministry of the
Environment, Etobicoke, Canada; 2University of Toronto,
Toronto, Canada; 3Thermo Scientific, San Jose, CA
Simultaneous Determination of Cationic and Anionic
Pharmaceuticals Using an Online SPE LC and a
High-Speed Polarity Switching ESI MS/MS; Mitsuha
Yoshikane1; Tairo Ogura2; Ichiro Hirano2; Yayoi Suzuki3;
Shoji Nakayama3; 1The University of Tokyo, Kashiwa,
Japan; 2Shimadzu Corporation, Kyoto, Japan; 3National
Institute for Environmental Studies, Tsukuba, Japan
Results of a National Scale Survey Investigating the
Occurrence of Prescription Pharmaceuticals Present
in Wastewater Discharges; Angela Batt; Mitchell Kostich;
Jim Lazorchak; U.S. Environmental Protection Agency,
Cincinnati, OH
Paper Spray Ionization of Herbicides from Dried Blood
Spot Cards; Steven L. Reeber; Sneha Gadi; Gary L. Glish;
University of North Carolina at Chapel Hill, Chapel Hill, NC
Determination of Glucocorticoid- And
Mineralocorticoid-Active Compounds in Waste and
River Waters by LC-MS/MS and in vitro Testing;
Adrian A Ammann1; Petra Macikova2; Ksenia J Groh1;
Kristin Schirmer1; Marc J.-F. Suter1; 1Eawag, Duebendorf,
Switzerland; 2Masaryk University, Brno, CZ
Quantitative Determination of Antidepressants by
Solvent Microextraction LC ESI-MS/MS in Biosolids
Destined for Land Application; Melissa M. Schultz; Lydia
Niemi; Madigan Murphy; Katherine Stencel; The College of
Wooster, Wooster, OH

TP 595

TP 596

TP 597

TP 598

TP 599

TP 600

TP 601

TP 602

TP 603

TP 604

TP 605

TP 606

Analysis of Targeted and Non-Targeted Identified
Contaminants in Storm Water Retention Ponds Using
LC-HRMS with Online Solid Phase Extraction; Jonathan
Beck1; P. Lee Ferguson2; Gordon Getzinger2; 1Thermo Fisher
Scientific, San Jose, CA; 2Duke University, Durham, NC
Trace Level Analysis of Herbicides in Drinking and
Surface Water by Online-SPE LC/Triple Quadrupole
MS to the Lower ppt Range; Edgar Naegele; Agilent
Technologies, Waldbronn, Germany
Analysis of Diquat and Paraquat Using UHPLC-MS/MS
and UHPLC-Orbitrap MS – Method Development, Matrix
Effects and Performance; Paul Yang1; Chunyan Hao1;
Franca Morra1; Xiaoming Zhao1; Xiaodong Liu2; Charles
Yang2; Jonathan Beck2; Maciej Bromirski2; Dipankar Ghosh2;
1
Ministry of the Environment, Etobicoke, Canada; 2Thermo
Scientific, San Jose, CA
Multi-Residue Method for the Target Analysis of
Pesticides in Crops by Liquid ChromatographyTandem Mass Spectrometry; Nam-Sun Kim; SeongSoo
Park; Hwa-Mi Lee; Mi-Jung Noh; Hyun-Sook Lee; SungIl
Kim; SeungYoung Park; KeunHwa Choi; Dae Hyun Cho;
Regional Food and Drug Administration, Incheon, Korea
Rapid and Simultaneous Identification and Quantitation
of Pesticides in different Matrices Using High Sensitive
LC/MS/MS; Karsten Ott1; Ugo Chiuminatto2; Sebastian
Fabritz2; Jianru Stahl-Zeng2; 1bilacon GmbH, Berlin,
Germany; 2AB Sciex, Darmstadt, Germany
Sensitive Quantification of Pesticides at Low ppt Levels
in Drinking Water Using High Performance Triple
Quadrupole Mass Spectrometer; Guifeng Jiang; Jia Wang;
Marcus Miller; Terry Zhang; Jonathan Beck; Charles Yang;
Dipankar Ghosh; Thermo Fisher Scientific, San Jose, CA
High Throughput Analysis of Pesticide Residues in
Raw Agricultural Commodities; Leah Riter; Chad Wujcik;
Monsanto, St. Louis, MO
Improved Screening for 500 Pesticides in Matrix Using a
LC-triple Quadrupole Mass Spectrometer; Marcus Miller;
Mary Blackburn; Dipankar Ghosh; Oleg Silva; ThermoFisher
Scientific, San Jose, CA
High-Throughput Simultaneous Analysis of Pesticides
by Supercritical Fluid Chromatography/Orbitrap
Mass Spectrometry; Megumi Ishibashi1; Miho Sakai1, 2;
Takashi Ando2; Tomoko Hamasaka3; Shigeru Sakamoto3;
Eiichiro Fukusaki1; Takeshi Bamba1; 1Graduate School of
Engineering, Osaka University, Suita, Japan; 2Miyazaki
Agricultural Research Institute, Miyazaki, Japan; 3Thermo
Fisher Scientific, Yokohama, Japan
On-line SPE Coupled to UHPLC MS/MS for Analysis of
Multiple TOrCs in Water Using Simultaneous Positive
and Negative Electrospray Ionization; Tarun Anumol1;
Sheher Mohsin2; Sylvain Merel1; Shane Snyder1; 1University of
Arizona, Tucson, AZ; 2Agilent Technologies, Schaumburg, IL
Simultaneous Screening Target and Non-Target
Pesticides in Vegetable by GC/Q-TOF MS with Accurate
Mass Ion Formula Database and Deconvolution
Technique; Fang Zhang1; Yinlong Guo1; Chongtian Yu2;
zhe Cao2; Zhixu Zhang2; 1Shanghai insititue of organic
chemistry, Shanghai, China; 2Agilent Technologies(China)
Co., Ltd., Shanghai, China
High Speed TOFMS for GC and GCxGC Endocrine
Disrupting Compounds Characterization in Biological
Samples for Environmental Risk Factors Assessment;
Daniela Cavagnino1; Antonella Siviero1; Alessandra
Mantegazza1; Veronica Termopoli2; Pierangela Palma2;
Giorgio Famiglini2; Anna Maria Lavezzi3; Luigi Matturri3;
Achille Cappiello2; 1DANI Instruments, Cologno Monzese,

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Italy; 2LC-MS Laboratory, DiSTeVA, University of Urbino,
Urbino, Italy; 3Research Center “Lino Rossi”, University of
Milan, Milan, Italy
A Novel Screening Method for Anthropogenic Sewage
Pollutants in Waste Water, Ground Water and Drinking
Water Samples by LC–HRAM Analysis; Sebastian
Westrup; Nick Duczak; Michal Godula; Thermo Fisher
Scientific, San Jose, CA

Ion Mobility Applications, 619 – 661
TP 619

TP 620

Elemental Analysis, 608 – 618
TP 608

TP 609

TP 610

TP 611

TP 612

TP 613

TP 614

TP 615

TP 616

TP 617

TP 618

Development of Capillary Electrophoresis Inductively
Coupled Plasma Mass Spectrometry for Quantitative
Analysis of Phosphorylated Peptide with Metrological
Traceability; Kyoung-Seok Lee1; Jinil Kim2; Yong-Hyeon
Yim1; Su Kyeong Bang2; Tae Kyu Kim2; 1KRISS, YuseongGu, Korea; 2Department of Chemistry, Pusan National
University, Busan, Korea
Optimizing Cold Cell LA-ICP-MS Conditions for the
Analysis of Elemental Localization and Imaging of
Biological Tissues; Jason Hamilton; William Hoffman;
Guido Verbeck; University of North Texas, Denton, TX
Reducing Matrix Effect through Femtosecond Laser
Ablation and Ionization; Bochao Zhang; Wei Hang;
Xiamen University, Xiamen, China
Development of a Method Based on Tandem Inductively
Coupled Plasma Mass Spectrometry for Determination
of Calcium/Phosphorus Ratio in Teeth Samples;
Mohamed Amr1; Saeed Al-Meer1; Khalid Al-Saad1; Elham
Fawzi2; 1Qatar University, Doha, Qatar; 2The Queen Dental
Center, Doha, Qatar
The State of the Matter: Providing Insight through
Chemical Speciation; Craig Westphal; DuPont,
Wilmington, DE
Analysis of Phosphorus in Some Environmental
Samples by ESI - Mass Spectrometry and ICP - Mass
Spectrometry; Jerzy Mierzwa; Tennessee State University,
Nashville, TN
Determination of Iopromide in Environmental Waters
by Ion Chromatography-ICP-MS; Armando Durazo; Tarun
Anumol; Shane A. Snyder; University of Arizona, Tucson, AZ
Redox Speciation Analysis of Iron by IonChromatography and ICP-MS Based on Speciated
Isotope Dilution Mass Spectrometry (EPA Method 6800);
Mesay M. Wolle1; Timothy Fahrenholtz2; G. M. Mizanur
Rahman2; Matt Pamuku2; H. M. “Skip” Kingston1; 1Duquesne
University, Pittsburgh, PA, 2Applied Isotope Technologies,
Pittsburgh, PA
Rapid Detection of Metal Contaminants Using Ambient
Mass Spectrometry; Jamie Nizzia; Christopher Mulligan;
Illinois State University, Normal, IL
Ultra-fast LDTD-APCI-MS/MS Analysis of Steroid
Hormones Oxidized in Surface Water Using Potassium
Permanganate; Paul Fayad1; Michele Prevost2; Sebastien
Sauve1; 1Universite de Montreal, Montreal, Canada; 2Ecole
Polytechnique de Montreal, Montreal, Canada
Simultaneous Analysis of Heavy-Metals by ICP-MS:
Efficiency of Clay, TiO2 and SiO2 Nanoparticles for the
Removal of Toxic-Metals from Water; Khalid A. Al-Saad1;
Mohamed A. Amr1; Saeed H. Almeer1; Aisha N. Alsaygh1;
Esraa Y. Abbas1; Mohammed A Abdul-Hakim1; Mohammed
S. Muthana1; Siham S. Hersi1; Noor M. Bader1; Ahmed A.
Ramadan1; Sakthivel Sundaresan2; Narendra Agnihotra2;
1
Qatar University, Doha, Qatar; 2TCE QSTP-LLC, Doha,
Qatar

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TP 621

TP 622

TP 623

TP 624

TP 625

TP 626

TP 627

TP 628

TP 629

Using Ion Mobility Spectrometry to Screen Small
Molecule Inhibitors for the Alzheimer’s Disease Aβ42
Protein; Xueyun Zheng; Michael Bowers; University of
California Santa Barbara, CA
Separation of Isomeric Cationized Diterpene Glycosides
from Stevia Rebaudiana Bertoni Leaves by Traveling
Wave Ion Mobility Mass Spectrometry (TWIM-MS);
Alessandra Tata1; Giovana Anceski Bataglion1; Gustavo
Henrique Martins Ferreira Souza2; Marcos Nogueira
Eberlin1; 1University of Campinas UNICAMP, Campinas
(SP), Brazil; 2MS Applications & Develop Lab, Waters
Corporation, Sao Paulo, Brazil
Separation and Characterization of Polymeric
Architectures by Matrix Assisted Ionization Vacuum
(MAIV)-Ion Mobility Spectrometry (IMS)-Mass
Spectrometry (MS); Lorelie Imperial1; Barbara Larsen2;
Scott Grayson3; Sarah Trimpin1; 1Department of Chemistry,
Wayne State University, Detroit, MI; 2The DuPont Company,
Wilmington, DE; 3Department of Chemistry, Tulane
University, New Orleans, LA
Ion Mobility-Mass Spectrometry Analysis of Globular
Electrosprayed Polymer Ions Obtained via Charge
Control; Ernesto Criado Hidalgo1, 2; Juan Fernández
García1; Juan Fernández de la Mora1; 1Yale University, New
Haven, CT; 2SEADM S.L., Boecillo, Spain
Characterization of Amino Acid and Peptide Isomers
Using Traveling Wave Ion Mobility Spectrometry-Mass
Spectrometry; Tawnya Flick; Chul Yoo; Iain Campuzano;
Michael Bartberger; Amgen, Inc., Thousand Oaks, CA
Spontaneous Cold Ionization and Characterization of
Molecules from Surfaces by Matrix Assisted Ionization
Vacuum Ion Mobility Spectrometry Mass Spectrometry;
Ellen D. Inutan; Sarah Trimpin; Wayne State University,
Detroit, MI
Hadamard Transform Atmospheric Pressure Ion
Mobility Time-of-Flight Mass Spectrometry for Complex
Sample Analysis; Xing Zhang1; William Siems1; Stephan
Graf2; Richard Knochenmuss2; Herbert Hill1; 1Washington
State University, Pullman, WA; 2Tofwerk AG, Thun,
Switzerland
Determination and Characterization of PFOS in
Environmental Samples Using Travelling Wave Ion
Mobility Mass Spectrometry; Michael McCullagh1;
Kendon Graham1; Dominic Roberts1; Kieran J Neeson1;
Jeff Goshawk1; Leonard Dillon1; Mike Hodgkinson1; Ingrid
Ericson2; Bert van Bavel2; 1Waters Corporation, Manchester,
UK; 2MTM Research Centre, Örebro University, Örebro,
Sweden
A Novel Approach to the Reduction of False Positive
and Negative Identifications in Screening of Pesticide
Residues in Food Analysis; Séverine Goscinny1; Michael
McCullagh2; Kieran Neeson2; Jeff Goshawk2; David
Eatough2; Sara Stead2; Ramesh Rao2; Dominic Roberts2;
1
Scientific Institute of Public Health, Brussels, Belgium;
2
Waters, Manchester, UK
Effective Analysis of Explosives with IMS-MS Using
Corona Discharge Ionization; Jihyeon Lee1; Soo Gyeong
Cho2; Eun Mee Goh2; Sungman Lee3; Sung-Suk Koh3;
Jeongkwon Kim1; 1Chungnam National University, Daejeon,
South Korea; 2Agency for Defense Development, Daejeon,
South Korea; 3Sensor Tech Inc., Kyunggi-Do, South Korea
Ion Evaporation from Amine-Nitrate Nanodrops Yields
Singly-Charged “Magic” Octamer Cluster-Ion; Juan
Fernández García; Juan Fernández de la Mora; Yale
University, New Haven, CT

61ST ASMS CONFERENCE ON MASS SPECTROMETRY

TUESDAY POSTERS

TP 630

TP 631

TP 632

TP 633

TP 634

TP 635

TP 636

TP 637

TP 638

TP 639

TP 640

TP 641

TP 642

Characterization of Amyloid β / Neuropeptide
interactions using Ion Mobility - Mass Spectrometry
and Site-Direct Mutagenesis; Molly T. Soper; Brandon T.
Ruotolo; Department of Chemistry, University of Michigan,
Ann Arbor, MI
The Effects of Polar Side Chains and Multiple Charges
on Conformational Preferences of Peptide Ions;
Chunying Xiao; David H. Russell; Texas A&M University,
College Station, Texas
Ion Cluster Effects on Differential Mobility as a Function
of ESI Flow Rate; Thomas Covey; Bradley Schneider; Jay
Corr; AB SCIEX, Concord, Canada
Ion Mobility Study of Isomeric Carbohydrates as their
Group I Metal Cation Adducts: Evidence for IsomerSpecific Conformations; Yuting Huang; Eric D. Dodds;
University of Nebraska-Lincoln, Lincoln, NE
Separation and Identification of Isomeric Glycans by
Trapped Ion Mobility Spectrometry-Fourier Transform
Mass Spectrometry; Yi Pu1; Mark Ridgeway2; Melvin
Park2; Cheng Lin3; Catherine E Costello1, 3; 1Boston
University, Boston, MA; 2Bruker Daltonics, Billerica, MA;
3
Boston University School of Medicine, Boston, MA
High Pressure Liquid Chromatography of Sugars and
Pharmaceuticals using a single Ambient Pressure
Ion Mobility LC Detector; Stephen Davila; Cheng-Hui
Yuan; Hermann Wollnik; Gary Eiceman; New Mexico State
University, Las Cruces, NM
Origin of Conformers Produced During Electrospray
Ionization Revealed by Cryogenic Ion Mobility-Mass
Spectrometry: A Benchmark Study Using Substance
P; Joshua A. Silveira1; Kyle L. Fort1; Nicholas A. Pierson2;
David E. Clemmer2; David H. Russell1; 1Texas A&M
University, College Station, TX; 2Indiana University,
Bloomington, IN
Analyzing/Separating Isomers, Conformers, Isobaric
Compounds and Other Closely Related Small
Molecules: An IMS Case Study; Filip Lemiere1, 2; Frank
Sobott1, 2; Jasper Boschmans1; Eliane Goossens1; Debbie
Dewaele1; 1Biomolecular Mass Spec., University of Antwerp,
Antwerp, Belgium; 2Centre for Proteomics, University of
Antwerp, Antwerp, Belgium
Characterizing Conformation of Peptides in Low
Dielectric Media Using Ion Mobility Mass Spectrometry;
Suk-Joon Hyung; Matthew Teague; Justin Stroh; Michael
Shapiro; Xidong Feng; Pfizer Worldwide Research, Groton, CT
Exploring nanoESI-DMS-MS/MS as a Rapid Quantitative
Platform; Amol Kafle1; Stephen Coy1; Adam Hall2; Sunita
Yadav1; James Glick1; Paul Vouros1; 1Northeastern
University, Boston, MA; 2Boston University, School of
Medicine, Boston, MA
Improved Accuracy of Isobaric Tagging in Quantitative
Proteomics Using High Field Asymmetric Waveform
Ion Mobility Spectrometry (FAIMS); Eric Bonneil1; Dave
Barnett2; Christelle Pomiès1; Pierre Thibault1; 1Universite
de Montréal, Montreal, Canada; 2Atlantic Cancer Research
Institute, Moncton, Canada
The Effects of Protein Glycation on Structural
Dynamics of αB-Crystallin; Weston Struwe; Georg
Hochberg; Justin Benesch; University of Oxford, Oxford, UK
Separation and Relative Quantitation of Complex
Lipid Regioisomers in Biological Extracts using
Differential Mobility Spectrometry; J. Larry Campbell1;
Eva Duchoslav1; J. C. Yves Le Blanc1; Chris M. Lock1; Alan
T. Maccarone2; Stephen J. Blanksby2; Todd W. Mitchell2;
1
AB SCIEX, Concord, Canada; 2University of Wollongong,
Wollongong, NSW, Australia

TP 643

TP 644

TP 645

TP 646

TP 647

TP 648

TP 649

TP 650

TP 651

TP 652

TP 653

TP 654

TP 655

Hofmeister Salts Recover a Misfolded Multiprotein
Complex for Subsequent Structural Measurements in
the Gas Phase; Linjie Han; Brandon Ruotolo; University of
Michigan, Ann Arbor, MI
Combined Crosslinking and Ion Mobility-Mass
Spectrometry for Structural Analysis of Protein
Complexes; Billy Clifford-Nunn; Linjie Han; Yueyang
Zhong; Philip Andrews; Brandon Ruotolo; University of
Michigan, Ann Arbor, MI
Exploring the Potential of Ion Mobility-Mass
Spectrometry in Protein Tyrosine Kinase Inhibitor
Discovery; Jessica N. Rabuck1; Matthew Soellner2;
Brandon T. Ruotolo1; 1Department of Chemistry, University
of Michigan, Ann Arbor, MI; 2College of Pharmacy,
University of Michigan, Ann Arbor, MI
A Robotically-sampled Electrospray Ion Mobility-Mass
Spectrometry Protocol for Structural Proteomics;
Yueyang Zhong; Brandon Ruotolo; University of Michigan,
Ann Arbor, MI
Structural Analysis of Transmembrane Spanning
Peptides by Drift Tube Based Ion-Mobility
Spectrometry; Christian Klein; Christine Miller; Ruwan
Kurulugama; Alexander Mordehai; Bill Barry; George
Stafford; Agilent Technologies, Santa Clara, CA
Probing Secondary Structure of Insulin B-chain by MSCID-IM-MS; Nathanael F Zinnel; David H. Russell; Texas
A&M University, College Station, TX
Insight into the Structure of Peptoids and ThioamideContaining Peptoids by Ion-Mobility Mass Spectrometry
(IMS); Magdalena Zimnicka; Institute of Organic Chemistry,
PAS, Warsaw, Poland
Ion Mobility-Mass Spectrometry and Molecular
Dynamics Simulations Reveal Structural Changes
of Metallothionein: The Effects of Metal Binding on
Conformation; Shu-Hua Chen; Liuxi Chen; David Russell;
Texas A&M University, College Station, TX
Conformation and Binding Differences between
Chemokine Analogs and Heparin as Determined by
Ion Mobility Mass Spectrometry; Youjin Seo; Christian
Bleiholder2; Armann Andaya1; Julie Leary1; 1UC Davis,
Davis, CA; 2UC Santa Barbara, Santa Barbara, CA
Applying a High Throughput IMS-QTOF MS Platform to
Complex Samples for Increased Molecular Coverage;
Erin Baker1; Kristin Burnum-Johnson1; Yehia Ibrahim1;
Daniel Orton1; Elizabeth Torres1; William Danielson1; Kevin
Crowell1; Matthew Monroe1; Gordon Slysz1; Mary Lipton1;
Thomas Metz1; Ruwan Kurulugama2; Alex Mordehai2; Ed
Darland2; George Stafford2; Gordon Anderson1; Richard
Smith1; 1Pacific Northwest National Laboratory, Richland,
WA; 2Agilent Technologies, Santa Clara, CA
Structural Characterization of Disulfide-BridgedPeptides; Philippe Massonnet1; Loïc Quinton1; Nicolas
Smargiasso1; Nicolas Gilles2; Edwin De Pauw1; 1Laboratory
of Mass Spectrometry, Ulg, Liège, Belgium; 2CEA/DSV/
iBiTec-S/SIMOPRO, Gif sur Yvette, France
Investigation of the Prebiotically Plausible Formation
of Water-soluble Polyesters by Traveling Wave Ion
Mobility-Mass Spectrometry; Manshui Zhou1; Irena
Mamajanov1; Francis Joseph Schork1; Ramanarayanan
Krishnamurthy2; Martha A Grover1; Nicholas V. Hud1;
Facundo M. Fernandez1; 1Georgia Institute of Technology,
Atlanta, GA; 2Scripps Research Institute, La Jolla, CA
Isomeric Separation and Structure Characterization
of Polar Compounds in Petroleum by traveling Wave
Ion Mobility Mass Spectrometry; Priscila M. Lalli1, 2;
David C. Podgorski1, 3; Yuri E. Corilo1, 3; Marcos N. Eberlin2;

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TUESDAY
POSTERS

TP 656

TP 657

TP 658

TP 659

TP 660

TP 661

Ryan P. Rodgers1, 3; Alan G. Marshall1, 4; 1National High
Magnetic Field Laboratory, Tallahassee, FL; 2ThoMSon
MS Laboratory, University of Campinas, Campinas, Brazil;
3
Florida State University Future Fuels Institute, Tallahassee,
FL; 4Florida State University, Department of Chemistry,
Tallahassee, FL
Global Peptide Collison Cross-section Profiling on
a Travelling Wave Ion Mobility Mass Spectrometer;
Christopher B. Lietz; Chenxi Jia; Lingjun Li; University of
Wisconsin, Madison, WI
Collision Cross Sections and Reduced Mobilities of
Endogenous Steroids in a Drift Tube IM-MS Using
Nitrogen Bath Gas; Christopher Crutchfield1; Stephanie
Cologna1; Peter Backlund1; Christian Klein2; Ruwan
Kurulugama2; Ed Darland2; Alex Mordehai2; Alfred L. Yergey
1 1
; NIH, Columbia, MD; 2Agilent Technologies, Santa Clara,
CA
Influence of Drift Gas in the Separation of
Hydroxybenzoic Acid Isomers (tautomers) via Traveling
Wave Ion Mobility Mass Spectrometry (TWIM-MS);
Renan S. Galaverna; Giovana A. Bataglion; Gabriel Heerdt;
Nelson H. Morgon; Marcos N. Eberlin; State university of
campinas, Campinas, Brasil
The Effect of Ion Temperature on the Conformation(s)
of Gas-Phase Peptide Ions: An Ion Mobility-Mass
Spectrometry Study; Kyle L. Fort; Joshua A. Silveira;
David H. Russell; Texas A&M University, College Station, TX
Theoretical Investigation on the Ion Mobility Separation
of Metal-Coordinated Oligosaccharide Isomers; Yiqun
Huang1; Erin Baker2; Catherine E. Costello1; Cheng Lin1;
1
Boston University School of Medicine, Boston, MA; 2Pacific
Northwest National Laboratory, Richland, WA
A Novel Approach to Improve Quantitation Accuracy
and Proteome Coverage Upon Application of TWIMS
(Travelling Wave Ion Mobility Mass Spectrometry); Pavel
Shliaha; Laurent Gatto; Nick Bond; Michael Muelleder;
Floriana Capuano; Markus Ralser; Kathryn Lilley; University
of Cambridge, Cambridge, UK
Ambient Ionization: Applications I, 662 – 690

TP 662

TP 663

TP 664

TP 665

In situ Analysis of Single Plant Cells by Laser Ablation
Electrospray Ionization Mass Spectrometry with Ion
Mobility Separation; Linwen Zhang1; Bindesh Shrestha1;
Éric Maréchal2; Denis Falconet2; Akos Vertes1; 1George
Washington University, Washington, DC; 2Université Joseph
Fourier Grenoble, Grenoble, France
Metabolic Analysis of Small Cell Populations by Plume
Collimation in LAESI Mass Spectrometry with Ion
Mobility Separation; McKenzie Floyd; Akos Vertes; George
Washington University, Washington, DC
Metabolomic and Lipidomic Analysis of Live Microalgae
by Laser Ablation Electrospray Ionization Mass
Spectrometry with Ion Mobility Separation; Sylwia
Stopka1; Bindesh Shrestha 1; Denis Falconet 2; Éric
Maréchal2; Akos Vertes1; 1George Washington University,
Washington, District Of Columbia; 2Université Joseph
Fourier Grenoble, Grenoble, France
Ex vivo Analysis of Lymnaea Organs by Laser Ablation
Electrospray Ionization Mass Spectrometry with Ion
Mobility Separation; Laine Compton1; Zsolt Pirger2; Laszlo
Mark3; Zita Laszlo2; Bindesh Shrestha1; Akos Vertes1;
1
George Washington University, Washington, District of
Columbia; 2Hungarian Academy of Sciences, Tihany,
Hungary; 3University of Pecs, Pecs, Hungary

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TP 673

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TP 676

TP 677

TP 678

TP 679

LAESI Mass Spectrometry Imaging of Contact Lens
Spoilage; Holly Henderson; Brent Reschke; Matthew
Powell; Callee Walsh; Trust Razunguzwa; Protea
Biosciences Group, Inc., Morgantown, WV
Characterization of Drugs in Dried Blood Spots
Using Electrospray Laser Desorption Ionization Mass
Spectrometry; Chin-Hsiung Wang; Min-Zong Huang;
Jentaie Shiea; National Sun Yat-Sen Univ., Kaohsiung,
Taiwan
Adding Ammonium Salts as Co-Matrices for Improving
Analyte Detection and Sensitivity Using Laserspray
Ionization Inlet (LSII); Nicholas Chubatyi; Charles
McEwen; University of the Sciences, Philadelphia, PA
Rapid Breath Profiling by Thermal Desorption –
Electrospray Mass Spectrometry; James Reynolds;
Cristina Guallar-Hoyas; Modupe Jimoh; Colin Creaser; Paul
Thomas; Loughborough University, Loughborough, UK
Solid Phase Microextraction Coupled with Thermal
Desorption Electrospray Ionization Mass Spectrometry
for the Detection of Trace Chemical Compounds in
Liquids; Min-Zong Huang; Jo-Han Chou; Jentaie Shiea;
National Sun Yat-Sen Univ., Kaohsiung, Taiwan
Rapid Determination of Urinary Creatinine Levels
Using Atmospheric Pressure Thermal Desorption
Combined with Ion Mobility-Mass Spectrometry; Neil
Devenport1; James Reynolds1; Daniel Weston2; Colin
Creaser1; 1Loughborough University, Loughborough, UK;
2
AstraZeneca, Alderley Edge, UK
Qualitative Analysis of 1-OHP with Extractive
Electrospray Ionization Mass Spectrometry from a Wet
Surface; Jing Li; Eric Handberg; Huanwen Chen; East
China Institute of Tech., Nanchang, China
Detection of Exhaled Nitric Oxide by Extractive
Electrospray Ionization Mass Spectrometry; Susu Pan1;
Yan Zhang1; JianHua Ding1; Jiuyan Zhao2; Lanlan Zhu2;
Qian Zeng1; Xinglei Zhang1; Eric Handberg1; Huanwen
Chen1; 1East China Institute of Tech., Nanchang, China;
2
Nanchang University, Nanchang, China
Electrospray Charging of Quartz, Olivine, and
Chondritic Meteorite Microparticles; Daniel Austin; Terik
Daly; Jonathan Kerby; Brigham Young University, Provo, UT
Differentiation of Two Morphologically Similar
Amazonian Aniba Species by Electron Spray Ionization
Mass Spectrometry; Carlos H.V. Fidelis1; Renan S.
Galaverna1; Lauro E.S. Barata2; Paulo T. B. Sampaio3;
Marcos N. Eberlin1; 1State University of Campinas,
Campinas, SP; 2Federal University of Western Pará
(UFOPa), Santarém, PA; 3National Research Institute of
Amazon, Manaus, AM
Direct Analysis of Herbal Powders by Pipette-tip
Electrospray Ionization Mass Spectrometry; Haixing
Wang; Zhong-Ping Yao; The Hong Kong Polytechnic
University, Hong Kong, China
Electrostatic-Spray Ionization Mass Spectrometry; Liang
Qiao1; Hubert Girault1; Romain Sartor1; Natalia Gasilova1;
Elena Tobolkina1; Baohong Liu2; 1École Polytechnique
Fédérale de Lausanne, Lausanne, Switzerland; 2Fudan
University, Shanghai, China
The Fast Screening Analysis for Alkylphenol and
Alkylphenol Ethoxylates Using Mass Spectrometer;
Nam-Yong Cheong1; Eun-Ho Shin1; Seung-Woon Myung2;
1
KATRi, Seoul, South Korea; 2Kyonggi University, Su-Won,
Kyonggi-do, Korea
Shvo’s Catalyst in Chemoenzymatic Dynamic
Kinetic Resolution of Amines - Inner or Outer Sphere
Mechanism? Cintia Milagre1; Boniek Vaz2; Marcos Eberlin3;

61ST ASMS CONFERENCE ON MASS SPECTROMETRY

TUESDAY POSTERS

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TP 681

TP 682

TP 683

TP 684

TP 685

TP 686

TP 687

TP 688

TP 689

TP 690

Humberto Milagre1; 1UNESP, Araraquara, Brazil; 2Federal
University of Goiás, Goiânia, Brazil; 3UNICAMP, Campinas,
Brazil
Accelerated Reactions in Small Volumes; Ryan Bain;
Michael Wleklinski; R. Graham Cooks; Purdue University,
West Lafayette, IN
Simple, Direct and Reliable Analysis of Bull Semen
Extracts and Intact Sperm Cells by Easy Ambient SonicSpray Ionization Mass Spectrometry; Anna Maria A. P.
Fernandes1; Nicolas V. Schwab1; Alessandra Tata1; Athos A.
Pastore2; Rosana M. Alberici1; Marcos N. Eberlin1; Christina
R. Ferreira3; 1ThoMSon Mass Spectrometry Laboratory,
UNICAMP, Campinas, SP, Brazil; 2CRV Lagoa, Sertãozinho,
SP, Brazil; 3Aston Labs, Purdue University, West Lafayette,
IN
Quality Control Analysis of Cosmetic Compounds
by Easy Ambient Sonic-Spray Ionization Mass
Spectrometry; Soraya Elkhatib; Rosana Alberici; Marcos
N. Eberlin; ThoMson Laboratory University of Campinas,
UNICAMP, Campinas, SP, Brazil
Detection of Ginkgo Tablets Adulteration Using Easy
Ambient Sonic Spray Ionization Mass Spectrometry;
Endler Borges1; Dietrich Volmer2; Marcos Eberlin1;
1
Unicamp, Campinas, Brazil; 2Saarland University,
Saarbrücken, Germany
A Digital Microfluidic Surface Acoustic Wave
Nebulization Chip for Direct Phosphoproteomic
Analysis; Yue Huang1; Michael Wilson1, 2; Scott Heron1,
2
; John Chapman1; J. Scott Edgar3; Sung Hwan Yoon1, 2;
David R. Goodlett1, 2; 1University of Washington, Seattle,
WA; 2University of Maryland, Baltimore, MD; 3Deurion LLC,
Seattle, WA
Preparative Scale Paper Spray for Small Scale Chemical
Synthesis; Xin Yan1; Xin Li1; Rodinei Augusti2; R. Graham
Cooks*1; 1Purdue University, West Lafayette, IN; 2Federal
University of Minas Gerais, Belo Horizonte, brazil
In-field Agrochemical Analysis Using Ambient Ionization
and a Handheld Mass Spectrometer; Pu Wei1; Joshua S.
Wiley1; Jiangjiang Liu1; Chris Pulliam1; Ayanna U. Jackson2;
Holger Tank2; Jeffrey R. Gilbert2; Jim Gifford2; Kerrm Yau2;
John Whitteck2; Zheng Ouyang1; R. Graham Cooks1;
1
Purdue University, West Lafayette, IN; 2Dow AgroSciences,
Indianapolis, IN
In-situ Analysis of Corrosion Inhibitors Using Paper
Spray Ionization Mass Spectrometry; Fred Paul Mark
Jjunju1; Anyin Li2; Abraham Badu-Tawiah2; Pu Wei2; Iman
Roqan1; R. Graham Cooks2; 1CEMSE KAUST, Thuwah,
KSA; 2Department of Chemistry Purdue University, West
Lafayette, IN
Improvement of Quantitative Performance of Paper
Spray Mass Spectrometry by oxidative Treatment Of
Paper Substrates; Yuan Su; Jiangjiang Liu; R. Graham
Cooks; Zheng Ouyang; Purdue University, West Lafayette,
IN
Quantitative Analysis of Triglycerides and Fatty Acid
Profiling in Oils and Oil Seeds Using Ambient Mass
Spectrometry; Jiangjiang Liu1; Pu Wei1; Joshua Wiley1;
Ayanna Jackson2; Paresh Sanghani2; Jeffery Gilbert2; Brita
McNew2; Zheng Ouyang1; R. Graham Cooks1; 1Purdue
University, West Lafayette, IN; 2Dow AgroSciences,
Indianapolis, IN
Direct Identification of Glycosyl Flavonoids in Bergamot
Tissues by Leaf Spray Ambient Mass Spectrometry;
Fabio Mazzotti; Leonardo Di Donna; Domenico Taverna;
Donatella Aiello; Anna Napoli; Giovanni Sindona;
Dipartimento di Chimica Università della Calabria,
Arcavacata Di Rende, Italy

Carbohydrates I, 691 – 714
TP 691

TP 692

TP 693

TP 694

TP 695

TP 696

TP 697

TP 698

TP 699

TP 700

TP 701

TP 702

Method Development for Compositional Analysis of
Free HS and HS in Proteoglycans from Human Serum
and Saliva; Wei Wei1; Rebecca Miller1; Susan Fisher2; Julie
Leary1; 1University of California, Davis, CA; 2University of
San Francisco Medical Center, San Francisco, CA
High Temperature LC-MS Analysis of Native and
Permethylated Glycans Derived from Glycoproteins;
Shiyue Zhou; Yunli Hu; James Blcakmer; Yehia Mechref;
Texas Tech University, Lubbock, TX
Robust Relative Quantitation of Dual Isotope Labeled
Glycans by Mass Spectrometry; Weiqian Cao; Wei Zhang;
Fudan University, Shanghai, China
Isomeric Separation of Procainamide Labeled N-Glycans
by Using Novel Superficially Porous Particle HILIC Column;
Shujuan Tao1; Yining Huang1; Barry Boyes2; Ron Orlando1;
1
Complex Carbohydrate Research Center, UGA, Athens, GA;
2
Advanced Material Technology, Inc., Wilmington, DE
Confident Identification of Isomeric N-glycan Structures
by Combined Ion Mobility Mass Spectrometry and
Hydrophilic Interaction Liquid Chromatography; Yoshiki
Yamaguchi1; Kenji Hirose2; Wataru Nishima1; Suyong Re1;
Yuji Sugita1; 1RIKEN, Wako-Shi, Japan; 2Nihon Waters K.K.,
Osaka, Japan
Nano-HILIC-Orbitrap-MS Combined with Linkage
Specific Derivatization of Sialic Acid for Improved
Characterization of Isomeric Sialylated N-Glycans in
Cancer Biomarker Discovery; Fateme Tousi1; William
Hancock1; Marina Hincapie1; Jonathan Bones2; 1Barnett
Institute, Northeastern University, Boston, MA; 2NIBRT,
Dublin, Ireland
N-glycan Analysis of Immunoglobulin G by Enzymatic
Release with Remove-iT Endo S and LC-MS; Elizabeth
McLeod; Paula Magnelli; Alicia Beliek; Xiaofeng Shi; Ellen
Guthrie; New England Biolabs, Ipswich, MA
A Fully Automated Workflow for LC-MS Analysis of
Labeled and Native N-Linked Glycans Released From
Proteins; Udayanath Aich1; Julian Saba2; Xiaodong Liu1;
Sergei Snovida3; Yury Agroskin1; Srinivasa Rao1; Chris
Pohl1; 1Thermofisher Scientific, Sunnyvale, CA; 2Thermo
Fisher Scientific, San Jose, CA; 3Thermo Fisher Scientific
Pierce, Rockford, IL
Data Analysis and Processing Strategy for Large
Scale Mass Spectrometry N-linked Glycan Relative
Quantification Studies; Amber Taylor; S. Hunter Walker;
David C. Muddiman; North Carolina State University,
Raleigh, NC
Novel N-linked Glycan Relative Quantification Strategy
via Stable-Isotope Labeled Hydrazone Formation and
Application to Biomarker Discovery Efforts in Ovarian
Cancer; S. Hunter Walker1; Amber D. Taylor1; William
A. Cliby2; David C. Muddiman1; 1North Carolina State
University, Raleigh, NC; 2Mayo Clinic College of Medicine,
Rochester, MN
Quantitative Analysis of Carbohydrates and Artificial
Sweeteners in Food Samples Using LC/MS with Postcolumn Reagent Addition and APCI Interface; Jie Xing1;
Yin Ling Chew*2; Zhe Sun1; Zhaoqi Zhan1; 1Shimadzu
(Asia Pacific) Pte Ltd, Singapore, Singapore; 2Department
of Chemistry, Faculty of Science,, National University of
Singapore, Singapore
Profiling of Permethylated Glycans Released and
Collected from Mouse Brain Sections Fixed to
Microscopic Slides; Yunli Hu; Shiyue Zhou; Sarah Khalil;
Calvin Renteria; Yehia Mechref; Texas Tech University,
Lubbock, TX

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TUESDAY
POSTERS

TP 703

TP 704

TP 705

TP 706

TP 707

TP 708

TP 709

TP 710

TP 711

TP 712

Comparative N-glycomic Profiling Differentiates Primary
Hepatocellular Carcinoma Tissue from Cirrhotic and
Normal Liver Tissues; Christa L. Feasley1; Matthew B.
West1, 3; Nikhil Mirjankar2; Barry K. Levine2; Christopher M.
West1; Marie H. Hanigan1; 1University of Oklahoma HSC,
Oklahoma City, OK; 2Oklahoma State University, Stillwater,
OK; 3Hough Ear Institute, Oklahoma City, OK
Tissue O-glycans Change during Mouse Natural Aging;
Bum Jin Kim1; Hyoung Jin Jeong1; Serenus Hua1, 2; Sureyya
Ozcan1, 2; Lauren Dimapasoc3; Ik-Soon Jang4; Jong-Soon
Choi4; Hyun Joo An1, 2; 1GRAST, Chungnam National
University, Daejeon, South Korea; 2Cancer Research
Institute, Daejeon, South Korea; 3University of California,
Davis, CA; 4Korea Basic Science Institute, Daejeon, South
Korea
N-glycan Profiling of the Urinary Exosome for
Biomarker Discovery; Nayoung Yun1; Seunghyup Jeong1;
Serenus Hua1; Pyong-Gon Moon2; Moon Chang Baek2;
Hyun Joo An1; 1Chungnam National University, Daejeon,
Korea; 2Kyungpook National University, Daegu, Korea
Mass Spectra Analysis of Bacteria-Resistant bus-4
Caenorhabditus elegans Mutants Reveals Defects
in O-glycoslyation; Lisa Parsons1; Rahman Mizanur2;
Ewa Jankowska1; Jonathan Hodgkin3; Delia O’Rourke3;
Dave Stroud3; John Cipollo1; 1FDA, Bethesda, Md; 2army,
Bethesda, US; 3Department of Biochemistry, University of
Oxford, Oxford, UK
Structural Determination of N-Glycans from Viral
Glycoproteins by Ion Mobility Mass Spectrometry
and Negative Ion Fragmentation; David J. Harvey1;
Christopher Scanlan1; Max Crispin1; Camille Bonomelli1;
Thomas Bowden1; Bitto David1; Huiskonen Juha1; Matthew
Edgeworth2; James Scrivens2; 1University of Oxford, Oxford,
UK; 2University of Warwick, Coventry, UK
Structural Elucidation of N-glycans Originating from
Ovarian Cancer Cells Using High Vacuum MALDI
Mass Spectrometry; Matthew S. F. Choo1; Roberto
Castangia2; Matthew E. Openshaw2; Omar Belgacem2;
Stuart M. Haslam1; Anne Dell1; 1Faculty of Natural Sciences,
Imperial College, London, UK; 2MALDI Applications Group,
Shimadzu, Kratos, Manchester, UK
MALDI and ESI MS-based Quantitative Analysis of
N-linked Glycans Using Carbonyl-Reactive Tandem
Mass Tags; Yan Liu1, 2; Xuefei Zhong1; Sergei Snovida 3;
John C. Rogers 3; Lingjun Li1; 1University of Wisconsin,
Madison, WI; 2Xiamen University, Xiamen, China; 3Thermo
Fisher Scientific, Rockford, IL
Detection and Quantification of Carbohydrates in the
Murine Gastrointestinal Tract Following Antibiotic
Treatment and During Clostridium difficile Infection;
Li Zhang1; Casey Theriot2; Thekkelnaycke Rajendiran1;
Jaeman Byun1; Stephen Brown1; Vincent Young3; 1University
of Michigan, Metabolomics Core Facility, Ann Arbor, MI;
2
University of MIchigan, Dept of Internal Medicine, Ann
Arbor, MI; 3The University of Michigan, Dept of Microbiology,
Ann Arbor, MI
Homeostasis of Plasma N-linked Glycome as Defined
in the Domestic Hen Model of Spontaneous Ovarian
Adenocarcinoma; Amber Cook1; S. Hunter Walker1; Amber
D. Taylor1; Adam M. Hawkridge2; James N. Petitte1; David C.
Muddiman1; 1North Carolina State University, Raleigh, NC;
2
Virginia Commonwealth University, Richmond, VA
Method for the Analysis of 4-aminobenzoic Acid Ethyl
Ester Derivatized N-linked Oligosaccharides from
Cytopreservative Solutions; Francis Murphy; Michael
Finan; Rodney Rocconi; Lewis Pannell; University of South
Alabama, Mobile, AL

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Rapid Differentiation of Core- and AntennaeFucosylation in N-glycans Using Procainamide Labeling
and ESI-QTOF MS/MS; Charles Nwosu; Hoi Kei (Natalie)
Yau; Steven Becht; William Bakewell; PPD, Middleton, WI
O-glycan Analysis of Glycoprotein by UPLC-ESI QTOF
MS through Beta-Elimination and Reductive Amination;
Song Klapoetke; Hongwei Xie; KBI, Durham, NC
Glycoproteins I, 715 – 737

TP 715

TP 716

TP 717

TP 718

TP 719

TP 720

TP 721

TP 722

TP 723

TP 724

TP 725

TP 726

Multidimensional Tandem Mass Spectrometry
Strategies for Extracting Complementary Connectivity
Information on Glycosylated Peptide Ions; Venkata Kolli;
Eric D. Dodds; Univ of Nebraska Lincoln, Lincoln, NE
In-depth Characterization of Glycopeptides by
Combination of CID and ETD Fragmentation after
Charge State Enhancement; Andreas Brekenfeld; Kristina
Marx; Andrea Kiehne; Markus Meyer; Bruker Daltonik
GmbH, Bremen, Germany
Functional Glycan Epitopes: Sequential Mass
Spectrometry, Spectral Matching, and Application to
Biological Samples; David Ashline; Andrew Hanneman;
Hailong Zhang; Vernon Reinhold; University of New
Hampshire, Durham, NH
Linking Quantitative Glycan Profiling with Sequential
Mass Spectrometry and Spectrum Matching for Detailed
Structure; Andrew Hanneman1, 2; David Ashline1; Hailong
Zhang1; Vernon Reinhold1; 1University of New Hampshire,
Durham, NH; 2Glycan Connections, Lee, NH
Rapid N-linked Glycan Glycopeptide Analysis of the
Biotherapeutic Erythropoietin (EPO) Using HILIC UPLC/
FLR and Mass Spectrometry; Mark Hilliard1; Pauline
Rudd1; Jonathan Bones 1; Ying Qing Yu2; 1NIBRT, Dublin,
Ireland; 2Waters, Milford, Boston, MA
Characterization of Glycopeptides in Tryptic Mixtures by
2D-UPLC (High/Low pH) – nanoESI-QTof; Irina Perdivara;
Kenneth B. Tomer; NIEHS, Rtp, NC
Resolution of Sialylated Glycopeptides Using a
Pentafluorophenylpropyl (F5) Stationary Phase;
Catherine A. Formolo; Karen W. Phinney; National Institute
of Standards and Technology, Gaithersburg, MD
Ion Mobility Mass Spectrometry of IgG Fc
Glycopeptides from Different Subclasses; Michiko Tajiri1;
Feifei Zhu2; Maissa M. Gaya2; Yoshinao Wada1; David E.
Clemmer2; 1Osaka MCHRI, Izumi, Osaka, Japan; 2Indiana
University, Bloomington, IN
Demonstration of Informational Power of Chip-Based
Liquid Chromatography-Ion Mobility Spectrometry Mass
Spectrometry for Glycopeptidomics; Kshitij Khatri1; Qi
Wang1; Crystal K. Cody2; Ruwan Kurulugama2; Ed Darland2;
Catherine E. Costello1; Joseph Zaia1; 1Boston University,
Boston, MA; 2Agilent Technologies, Santa Clara, CA
A Robust LC-MS Based Workflow for Comparative
Glycoproteomics with Online Glycopeptide Enrichment
and Separation; Kshitij Khatri1; Nancy Leymarie1; Gregory
O. Staples2; Yu Huang1; Deborah R. Leon1; Joseph Zaia1;
1
Boston University, Boston, MA; 2Agilent Technologies,
Santa Clara, CA
Highly Selective Enrichment of Sialylated Glycopeptides
Using Titania Sol-Gels for MALDI-MS Applications; H.
Mehmet Kayılı; Ömür Çelikbıçak; Bekir Salih; Hacettepe
University, Department of Chemistry, Ankara, Turkey
Magnetic Nanoparticle Technology for Sequestering
Glycopeptides; Edward Bodnar; Hélène Perreault;
University of Manitoba, Winnipeg, Canada

61ST ASMS CONFERENCE ON MASS SPECTROMETRY

TUESDAY POSTERS

TP 727

TP 728

TP 729

TP 730

TP 731

TP 732

TP 733

TP 734

TP 735

TP 736

TP 737

Comparison of Hydrazide Capture and Lectin Affinity
Based Enrichment Methods for Glycoproteomics; Yue
Zhou; Peng Xue; Xiang Ding; Jun Wang; Fu quan Yang;
Institute of biophysics,CAS, Beijing, China
Sugar-azide Metabolic Labeling Combined with Alkynebead Capture for Efficient Isolation of Glycoproteins
Involved in the Epithelial-Mesenchymal Transition;
Stephen Roper; Arch Martin; Benjamin Neely; E. Ellen
Jones; Harry Drabkin; Robert Gemmill; Richard R Drake;
Medical University of South Carolina, Charleston, SC
Negative-Ion MALDI-QIT-TOF MSn of N-glycans
Derivatized with Pyrene Butanoic Acid Hydrazide;
Kazuko Hirose-Hachisu; Junko Amano; The Noguchi
Institute, Tokyo, Japan
The GlycoFilter: A Simple and Comprehensive Sample
Preparation Platform for Proteomics, N-Glycomics
and Glycosylation Site Assignment; Hui Zhou; John
Froehlich; Andrew Briscoe; Richard Lee; Boston Children’s
Hospital, Boston, MA
MALDI and ESI Evaluation of Glycopeptide Signal
Strengths for Quantitative Label-Free Glycoproteomics:
Demystifying Glycopeptide Ionisation Using
Synthetically Produced Sialylated N-glycopeptides;
Kathrin Stavenhagen1, 2; Hannes Hinneburg1; Morten
Thaysen-Andersen3; Laura Hartmann1; Daniel Varón Silva1;
Jens Fuchser4; Stephanie Kaspar4; Erdmann Rapp2; Peter
H. Seeberger1, 5; Daniel Kolarich1; 1Max Planck Institute
of Colloids and Interfaces, Berlin, Germany; 2MPI for
Dynamics of Complex Technical Systems, Magdeburg,
Germany; 3Macquarie University, Sydney, Australia; 4Bruker
Daltonics, Bremen, Germany; 5Free University Berlin,
Berlin, Germany
Mass Spectrometry Analysis of NXS/T Glycosylation
Sites in Recombinant Glycoproteins; Izabela
Sokolowska; Armand Ngounou Wetie; Urmi Roy;
Christopher Talbot; Alisa Woods; Costel Darie; Clarkson
University, Potsdam, NY
Top-Down Analysis of Plasma-Derived and
Recombinant Human Factor VII and Bovine
Prothrombin Reveal Extensive, Cell-Line Related
Heterogeneity of PTMs; Stephen Harvey; Julie Kirihara;
Lorraine Anderson; Matthew Wroblewski; Gary Nelsestuen;
University of Minnesota, Minneapolis, MN
Novel Strategy for Prediction of MSn Spectrum of
Glycans from its Structure; Hiromitsu Takaba1; Qi
Xiaofeng1; Hiroshi Setogawa1; Atsushi Ogiwara2; Kazuko
Hirose-Hachisu3; Mitsuhiro Kanazawa2; Junko Amano3;
1
Tohoku University, Sendai, Japan; 2Reifycs Inc., Tokyo,
Japan; 3The Noguchi Institute, Tokyo, Japan
Comparison of Trypsin and Nonspecific Digestions
for Site Specific Characterization of Protein Glycans
Utilizing New Software for Automated Matching and
Scoring; Evan Parker; Qiuting Hong; Andres Guerrero;
Michael Xin Sun; Jincui Huang; Carlito Lebrilla; UC,, Davis,
CA
GLIDE : GLycoprotein IDEntification software; Atsushi
Ogiwara1; Hisae Anyoji1; Mitsuhiro Kanazawa1; Kazuko
Hirose-Hachisu3; Hiromitsu Takaba2; Junko Amano3;
1
Reifycs Inc., Tokyo, Japan; 2Tohoku University, Sendai,
Japan; 3The Noguchi Institute, Tokyo, Japan
O-Glycomap-Sera: A Tool for Discovery of O-linked
Glycopeptides in Human Serum Samples; Jagadheshwar
Balan1; Anoop Mayampurath1; Chuan-Yih Yu1; Yehia
Mehcref2; Haixu Tang1; 1Indiana University Bloomington,
Bloomington, IN; 2Texas Tech University, Lubbock, TX

Food Safety, 738 – 772
TP 738

TP 739

TP 740

TP 741

TP 742

TP 743

TP 744

TP 745

TP 746

TP 747

TP 748

Method Development for Trace Level Detection of
N-Nitrosamines in Beer by GC-MS/MS; Lai Chin Loo1;
Cynthia Melanie Lahey1; Shao Hua Chia2; Fang Yan Li3;
Yai Fong Chew3; Gee Siang Ling1; Sheot Harn Chan3;
S. F. Y. Li2; 1Shimadzu Asia Pacific Pte. Ltd., Singapore;
2
National University of Singapore, Singapore; 3Food Safety
Laboratory, Health Science Authority, Singapore
Minimization of Carryover for High Throughput LCMS/MS Analysis of 14 Mycotoxins in Beer; Masayoshi
Tamura1; Keiko Matsumoto2; Jun Watanabe2; Junko Iida2;
Naoki Mochizuki1; 1Asahi Group Holdings, Limited, Ibaraki,
Japan; 2Shimadzu Corporation, Kyoto, Japan
Determination of 20 Phthalic Acid Esters in
Alcohol Drinks by Ultra High Performance Liquid
Chromatography/Tandem Mass Spectrometry; Hengtao
Dong; Jinting Yao; Hongyuan Hao; Luying Zhou; Qiang
Li; Yuling Song; Taohong Huang; Shin-ichi Kawano; Yuki
Hashi; Shimadzu (China) Co., Ltd., Shanghai, China
Determination of Industrial Dyes in Foods by LCMS-ITTOF; Xiaozhen Chen1; Liying Huang1; Jin Wang 1; Hui Cao1;
Luying Zhou2; Jinting Yao2; Hengtao Dong2; Hongyuan
Hao2; Taohong Huang2; Yuki Hashi2; 1Zhejiang Institute of
Quality Inspection Science, Hangzhou, China; 2Shimadzu
Global COE, Shimadzu (China) Co., Ltd, Shanghai, China
Determination of the Derivatives of Nitrofuran
Metabolites in Marine Products by Ultra High
Performance Liquid Chromatography/Triple Quadrupole
Mass Spectrometry; Xiongxiong Qiu; Jinting Yao; Song
Zhan; Taohong Huang; Shimadzu Global COE, Shimadzu
(China) Co., Ltd. Guangzhou, China
Ultra High performance Liquid Chromatography Tandem
Quadrupole-Time of Flight Mass Spectrometry for
Simultaneous Screening Hazardous Compounds in
Food Samples; Chuanqi Zheng; Agilent Technologies,
Guangzhou, China
Determination of Six Major Ergot Alkaloids and Their
Epimers in Wheat Using LC-MS/MS; Mike Roscoe;
Dainna Drul; Sheryl tittlemier; Canadian Grain Commission,
Winnipeg, Canada
Direct Analysis of 4-Methylimidazole in Foods using
Paper Spray Mass Spectrometry; Anyin Li1; Pu Wei1;
Hsu-Chen Hsu1; Linfan Li2; Zheng Ouyang2; R. Graham
Cooks1; 1Department of Chemistry, Purdue University, West
Lafayette, IN; 2Biomedical Engineering, Purdue University,
West Lafayette, IN
Rapid Simultaneous Assay of 25 Mycotoxines in a
Variety of Food Samples by UHPLC-MS/MS Using Fast
Polarity Switching; Eric Capodanno1; Stéphane Moreau2;
Mikael Levi2; 1Phytocontrol, Nimes, France; 2Shimadzu
France, Noisiel, France
Development and Application of an Exact Mass LCMS/MS Library for Screening of Mycotoxins and
Fungal Metabolites in Food and Feed; Elisabeth Varga1;
Thomas Glauner2; Bernhard Wuest2; Michael Sulyok 1;
Rainer Schuhmacher 1; Rudolf Krska 1; Franz Berthiller 1;
1
University of Natural Resources and Life Sciences, Tulln,
Austria; 2Agilent Technologies, Waldbronn, Germany
Identification and Quantification of 19 Phthalic Acid
Esters in Chinese Liquors Using GC-MS/MS; Xing
Jiangtao; Gao Peng; Wang Furong; Fan Jun; Shimadzu
Global COE, Shimadzu (China) Co., Ltd., Being, China

61ST ASMS CONFERENCE ON MASS SPECTROMETRY						

PAGE 117

TUESDAY
POSTERS
GENERAL
INFORMATION

TP 749

TP 750

TP 751

TP 752

TP 753

TP 754

TP 755

TP 756

TP 757

TP 758

TP 759

TP 760

TP 761

Identification and Quantitation of Beta-Agonists in Beef
and Pork Extracts Using Ultra-High Performance Liquid
Chromatography Tandem Mass Spectrometry with
Triggered Multiple Reaction Monitoring; Shan-An Chan;
Agilent, Taipei, Taiwan
Using Ion Mobility Mass Spectrometry to Identify
Multiple Protonation Sites and Different Fragmentation
Patterns Within the Fluoroquinolone Class of
Antibiotics; Michael McCullagh1; Sara Stead1; David
Eatough1; Kieran Neeson1; Jeff Goshawk1; Wouter de
Keizer2; Aldert Bergwerff2; 1Waters, Manchester, UK;
2
RnAssays BV, Utrecht, The Netherlands
Rapid Screening of Sorbic and Benzoic Acids in Soy
Sauce by Direct Analysis in Real Time Time-of-Flight
Mass Spectrometry; Xiaojing Ding1; Junwei Huang2; Shan
Zhao1; Jing Zhang1; Echo W. Jia2; Bing Shao1; Charles C.
Liu2; 1Beijing Centre for Disease Control and Prevention,
Beijing, China; 2ASPEC Technologies Limited, Beijing,
China
Multi Antibiotic Residue Detection - Status quo
and Challenges for Confirmatory and Screening
approaches; Nelli Jochim1; Lutz Hartig1; Scarlett Biselli1;
Sebastian Westrup2; 1Eurofins WEJ Contaminants,
Hamburg, Germany; 2Thermo Scientific, Dreieich, Germany
HighResolution Mass Spectrometric Characterization of
Toxic Jatropha Factors from Jatropha curcas: Possible
Contaminants in Animal Feed and Non-Food Grade
Glycerin; Hiranthi Jayasuriya; Upul Nishshanka; Renate
Reimschuessel; Chaitali Chattopadhaya; FDA, CVM, Laurel,
MD
Rapid, High Throughput Quantitation of Thujone in
Absinthe by UHPLC-MS-MS; Jared Russell; Jeffrey Dahl;
Shimadzu Scientific Instruments, Columbia, MD
Analysis of Non-steroidal Anti-inflammatory Drugs
in Food Matrices by Means of HPLC-MS/MS; Pavel
Metalnikov; Alexandre Komarov; Alexandre Panin; VGNKI,
Moscow, Russian Federation
Overcoming Challenges of Protein Sample Preparation
for Food Allergen Analysis; Rachel Lieberman1; Brian
Feild1; Scott Kuzdzal1; Kevin Meyer2; Nick Herold2;
1
Shimadzu Scientific Instruments, Columbia, MD; 2Perfinity
Biosciences, Inc., West Lafeyette, IN
Development and Evaluation of a Standardized Method
for Food Contaminant Analysis Based on Liquid-LiquidExtraction or QuEChERS, UHPLC and HRAM Platform;
Jinyuan Wang; Jonathan Beck; Charles Yang; Guifeng
Jiang; Jennifer Massi; Thermo Fisher Scientific, San Jose,
CA
High-Throughput Screening of Illegal Drugs in
Functional Foods by Ultra Performance Liquid
Chromatography Coupled with Quadrupole-Time Of
Flight Mass Spectrometry; Qiaozhen Guo; Jie Yin; Jing
Zhang; Bing Shao; Beijing Center for Disease Control and
Prevention, Beijing, China
Determination of 62 Non-Dioxin-Like PCBs and 7
indicatorPCBs in Food; Jungju Seo; Jijeong Ryu;
Seunghee Ahn; Korea Basic Science Institute, Seoul, South
Korea
Determination of Antibiotics in Honey by LC-MSMS
– The Replacement Three Methods with One Single
Method; Leena Saari; Finnish Food Safety Authority,
Helsinki, Finland
Determination of Arsenic Speciation in Rice Grain by ICICP-MS; Cheong-Tae Kim1; Youn-Jee Kim1; Dae-Hyun Kim1;
Seung-Il Yang2; Jung-Kun Lee1; 1NONGSHIM CO., LTD,
Seoul, South Korea; 2ThermoFisher Scientific-Korea, Seoul,
South Korea

PAGE 118					

TP 762

TP 763

TP 764

TP 765

TP 766

TP 767

TP 768

TP 769

TP 770

TP 771

TP 772

Comparison of Low-Resolution MSn Data and
High- Resolution Mass Spectrometric Data for NonTargeted Analysis Using Spectral Data Interpretation
Software; Carrie Sisk1; Ann Knolhoff2; Timothy Croley2;
1
Commonwealth of Virginia DCLS, Richmond, VA; 2FDA,
CFSAN, College Park, MD
Analysis of Antibiotics in Food Matrix Using LC High
Resolution Accurate Mass Spectrometry; Jia Wang;
Charles Yang; Dipankar Ghosh; Thermo Fisher Scientific,
San Jose, CA
Improving a Regulatory Method to Quantify
Triarylmethane Dyes in Fish Tissue; Sarah Pierce; Darin
Files; Haejung An; Eugene Chang; Han Paek; US Food &
Drug Administration, Irvine, CA
Extraction of Jatropha Factors from Glycerin for
Analysis using LC/MS; Bethany Subel; Jonathan Litzau;
FDA, Cincinnati, OH
Proteomic Analysis of Poor and Robust Colonizing
Campylobacter jejuni Isolates from Chick Cecum; Yuan
Gao1; Kidon Sung1; Saeed Khan1; Kelli Hiett2; Eric Line2;
Oh-Gew Kweon1; Carl Cerniglia1; Li-Rong Yu1; 1National
Center for Toxicological Research, US FDA, Jefferson, AR;
2
Agricultural Research Service, USDA, Athens, GA
Comparison Quantitation Ability of Quadrupole-Orbitrap
HR/AM MS and Triple Quadrupole MS in Food Additives
within Candies; Shu-Hui Lee; Hsin-Hung Huang; Wei-Shun
Lai; Mass Solutions Technology, New Taipei City, Taiwan
A Study of the Presence of Arecoline and Guvacoline in
Saliva of ‘Betel-Quid’ Chewer Using Ion Trap LC/MS; A.
F. M. Motiur Rahman; Mohamed W. Attwa; Adnan, A. Kadi;
King Saud University, Riyadh, SAUDI ARABIA
Direct Detection of Illegal Additives in Red Wine Using
MALDI-FTMS; Hai Pu; Nan Hu; Ow Saw Yen; Bruker,
Beijing, China
Identification of True and Fake Wines Using Single
Photon Ionization Mass Spectrometry; Cao Li1; Ya-Fei
Zhou1; Ya-Li Liu1, 3; Wei Gao2; Zhen Zhou2; Eric Handberg1;
Huanwen Chen1; 1East China Institute of Tech., Nanchang,
China; 2Shanghai University, Shanghai, China; 3Hebei
University of Technology, Tianjin, China
Nanotile based UPLC - Mass Spectrometry for Anabolic
Steroids Analysis in Food Safety; Arjen Gerssen1;
Eric O. van Bennekom1; Marco H. Blokland1; Saskia S.
Sterk1; Michel W.F. Nielen1, 2; 1RIKILT - Institute of Food
Safety, Wageningen UR, Wageningen, The Netherlands;
2
Laboratory of Organic Chemistry, Wageningen UR,
Wageningen, The Netherlands
Determination of Urethane in Chinese Rice Wine
by Supported Liquid Extraction Coupled and Gas
Chromatography-Mass Spectrometry; Suzi Qin; Jack Liu;
Wan Wang; Guotao Lu; Bonna-Agela Technologies, Tianjin,
China

61ST ASMS CONFERENCE ON MASS SPECTROMETRY

WEDNESDAY POSTERS

7:30-8:00 am.......................................... Set up all Wednesday posters
10:30 am-1:00 pm................................Odd-numbered posters present
12:00-2:30 pm.................................... Even-numbered posters present
7:30-8:00 pm....................................... Remove all Wednesday posters
Mass Spectrometry - History & Education.................................001-002
Nanomaterials...........................................................................003-012
Environmental Analysis: General II...........................................013-035
Environmental Analysis: Hydrocarbons and DOM....................036-044
Energy: Hydrocarbons and Petrochemical................................045-069
Small Molecules: Quantitative Analysis III.................................070-097
Diagnostic Clinical Chemistry: Small Molecules II..................... 098-116
Forensics - Drugs of Abuse....................................................... 117-135
Imaging MS: Method Development I.........................................136-157
Imaging MS: Software...............................................................158-169
Imaging MS: Pharmaceutical Applications................................170-193
Imaging MS: Small Molecules...................................................194-221
Informatics: Small Molecule ID and Characterization................222-233
Small Molecules: Qualitative Analysis.......................................234-251
Drug Metabolism: Qualitative Analysis......................................252-282
Drug and Metabolite Analysis: Novel Approaches for Dried
Biological Samples............................................................283-291
Metabolomics: Quantitative Analysis......................................... 292-311

Mass Spectrometry - History & Education, 001 – 002
WP 001 Origin, Growth, and Development of the Mass
Spectrometry Societies; P. Jane Gale1; Michael A.
Grayson2; 1Gale-Bentz Consulting, Southborough, MA;
2
Retired, St. Charles, MO
WP 002 Chem./Bio. 429 - Experimental Genomics and
Proteomics. An Interdisciplinary Upper-Division
Laboratory Course for Undergraduates; Charlotte
Platner; Jacquelyn Blake-Hedges; Samuel Clamons;
Ruth Dana; Adam Drici; Sophia Dudte; Gregory Ginsburg;
Veronica Gray; Alexandra Mellis; Allison Roberts; Charles
Thompson; Stephanie Wraith; Mark Forsyth; Margaret Saha;
Kurt Williamson; John Poutsma; College of William & Mary,
Williamsburg, VA
Nanomaterials, 003 – 012
WP 003 Functionalized Gold Nanoparticle Coated Surfaces for
the Detection of Biomolecules by Laser Desorption/
Ionization Mass Spectrometry; Alyssa L. M. Marsico;
Brian Creran; Bradley Duncan; Vikas Nandwana; Vincent
M. Rotello; Richard W. Vachet; University of Massachusetts,
Amherst, Ma
WP 004 Improving MS Sensitivity for Underivatized
Carbohydrates with Diamond Nanoparticles in MALDI;
Hsun Lee; Chia-Chen Wang; Chieh-Lin Wu; Yin-Hung Lai;
Jia-Der Lin; Yi-Sheng Wang*; Genomics Research Center,
Academia Sinica, Taipei 115, Taiwan, ROC
WP 005 Investigating the Impact of Nanoparticle Surface
Ligand Structures on Protein Adsorption by Mass
Spectrometry; Shang Zeng; Wenwan Zhong; University of
California, Riverside, CA
WP 006 Graphene/Polyaniline Nanocomposite Along
with MALDI-MS for Sensitive Detection of Small
Biomolecules; Nadnudda Rodthongkum1; Nipapan
Ruecha1; Voravee Hoven1; Richard Vachet2; Orawon
Chailapakul1; 1Chulalongkorn University, Bangkok, Thailand;
2
University of Massachusetts, Amherst, MA
WP 007 A Sol-Gel Derived Silver Nanoparticle Embedded Thin
Film for Mass Spectrometry-Based Biosensing; Roberto
Gamez; David Russell; Texas A&M University, College
Station, TX

Metabolomics: Clinical Applications..........................................312-323
Food “omics” MS Characterization of Food and Nutritional
Supplements.....................................................................324-355
Food Safety...............................................................................356-372
H/D Exchange, Software and Hardware...................................373-385
H/D Exchange: Protein Structure/Function II............................386-400
Proteins: Non-Covalent Interactions..........................................401-421
Antibody & Antibody Drug Conjugates......................................422-446
Analysis of Biosimilars...............................................................447-452
Biomarkers: Discovery..............................................................453-475
Biomarker Quantitation: New Methods......................................476-489
Proteins: Complexes and Aggregation......................................490-514
Proteins PTM I...........................................................................515-539
Peptides: PTM Identifications....................................................540-574
Informatics: Peptide Identification/Characterization I................575-596
Informatics: Post-Translational Modifications............................597-607
Peptides: Quantitative Analysis II..............................................608-643
Phosphopeptides: Enrichment Methods....................................644-668
Advances in Separation Techniques for Proteomic
Applications.......................................................................669-684
Interactions and Pathway Analysis............................................685-706
Ambient Ionization: Applications II.............................................707-734
Ion Mobility Fundamentals........................................................735-754

WP 008 Mass Spectrometric Analysis of Impurities in Crystalline
Organic Semiconductors; Anna Voloshenko1; Ke Jie Tan2;
Christian Kloc2; Rimma Shelkov1; Sergey Sladkevich1; Peter
Prikhodchenko1; Jenny Gun1; Ovadia Lev1; 1The Hebrew
University of Jerusalem, Jerusalem, Israel; 2Nanyang
Technological University, Singapore
WP 009 Mass Spectrometric Analysis of Species Evolution
in Mesoporous Silica Synthesis; Ivy Hwee Lim; Ferdi
Schüth; Wolfgang Schrader; Max-Planck-Institut für
Kohlenforschung, Mülheim An Der Ruhr, Germany
WP 010 Phenylboronic Acid-Decorated Lectins for Specific
Enrichment of Glycoproteins and Their Glycoproteomic
Application; Ying-Wei Lu1; Chih-Wei Chien1; Po-Chiao Lin2;
Sz-Wei Wu3; Chang-Yang Chen4; Chia-Li Han3; Kay-Hooi
Khoo3; Chun-Cheng Lin1; Yu-Ju Chen3; 1National Tsing
Hua University, Hsinchu, Taiwan; 2National Sun Yat-sen
University, Kaohsiung, Taiwan; 3Academia Sinica, Taipei,
Taiwan; 4National Taiwan Normal University, Taiperi, Taiwan
WP 011 Photocatalytic Nanoweb for Matrix-Free MALDI-TOF
Mass Spectrometry; Jo-Il Kim1; Su-Yeol Ryu2; Seung-Yeop
Kwak2; Min-Jung Kang3; Jae-Chul Pyun1; 1Yonsei University,
Seoul, Republic of Korea; 2Seoul National University,
Seoul, Republic of Korea; 3Korea Institute of Science and
Technology, Seoul, Republic of Korea
WP 012 TiO2 Nanowire Array for Matrix-Free MALDI-TOF Mass
Spectrometry; Jo-Il Kim1; Min-Jung Kang2; Jae-Chul Pyun1;
1
Yonsei University, Seoul, Republic of Korea; 2Korea Institute
of Science and Technology, Seoul, Republic of Korea
Environmental Analysis: General II, 013 – 035
WP 013 LC/QTOF Confirmation of Previously Unreported
Microcystins in Alberta Lake Waters; Ralph Hindle1;
Xu Zhang2; 1Vogon Laboratory Services Ltd., Cochrane,
Canada; 2Alberta Centre for Toxicology, Calgary, Canada
WP 014 Using LDTD-APCI-MS/MS for the Ultrafast Analysis of
Emerging Contaminants; Sébastien Sauvé; Université de
Montreal, Montreal, Canada
WP 015 The Comprehensive Analysis of CID MS/MS Spectra Of
Bisphenol A Derivatives; Wei Zou; Anupama Aditham; Qi
Gavin; Jianwen She; California Department of Public Health,
Richmond, CA

61ST ASMS CONFERENCE ON MASS SPECTROMETRY						

PAGE 119

GENERAL
INFORMATION
WEDNESDAY
POSTERS

WP 016 Analysis of Naphthenic Acids in Tissue by Liquid
Chromatography Tandem Mass Spectrometry; Million
Woudneh; Coreen Hamilton; Guanghui Wang; Jonathan
Benskin; John Cosgrove; AXYS Analytical Services Ltd.,
Sidney, Canada
WP 017 High-Throughput LC-MS/MS assay of Phthalates; Hui
Qiao; Sha Joshua Ye; Changtong Hao; IONICS Mass
Spectrometry Group Inc, Bolton, Canada
WP 018 QuEChERS Extraction for the Determination of
Free Microcystins in Fish Muscle Using Liquid
Chromatography/Tandem Mass Spectrometry; Xu
Zhang; David Kinniburgh; ACFT, University of Calgary,
Calgary, Canada
WP 019 Analysis of Fish Tissue for Perfluorinated Compounds
by Reversed Phase High Performance Liquid
Chromatography Multiple Reaction Monitoring Tandem
Mass Spectrometry; Michael Stagliano; Joseph Colombo;
Paul Gulyas; Matthew Geiger; Bonnie Taffe; Mi. Dept. of
Community Health, Lansing, MI
WP 020 Cyanobacterial Toxins Analysis by Direct Aqueous
Injection High Performance Liquid Chromatography
– Quadrupole Linear Ion Trap Tandem Mass
Spectrometry; Curtis Hedman1; Stacy Tremintin2; William
Krick1; 1WI State Lab of Hygiene, Madison, WI; 2AB SCIEX,
Foster City, CA
WP 021 Full Scan Tandem Quadrupole Mass Spectrometry for
the Determination of Novel Chlorinated Environmental
Pollutants; Qian Wang; Gergana Georgieva; M. Paul
Chiarelli; Loyola University, Chicago, IL
WP 022 Drinking Water Disinfection by Peracetic Acid and
Disinfection Byproducts Studied by UFLC-MS/MS and
GC-MS; Honglan Shi1; Ruipu Mu1; Yongbo Dan1; Qihua
Wu1; Danielle West1; Yinfa Ma1; John Yang2; Bin Hua2; Enos
Inniss3; 1Missouri University of Science and Technology,
Rolla, MO; 2Linclon University, Jefferson City, MO;
3
University of Missouri, Columbia, MO
WP 023 Tandem Quadrupole Mass Spectrometry for the
Determination of Glucuronides Found in Surface and
Waste Water; Matthew Reichert; Deepika Panawennage;
Gergana Georgieva; M. Paul Chiarelli; Loyola University,
Chicago, IL
WP 024 Fast Analysis of Cyanobacterial Toxins in Water
by Online Preconcentration-Orbitrap MS and Flow
Injection-LC-MS/MS and Removal Properties of
Chlorination; Jaewon Choi1; Jeheon Jang1; Yuns Kim1;
Charles Yang2; Dipankar Ghosh2; 1Kwater, Daejeon, South
Korea; 2Thermofisher, San Jose, ca
WP 025 The Effects of Acid Pretreatment on the Measurement
of 28 VOC Metabolites in Urine by UPLC-ESI-MS/MS;
Liqun Wang; K. Udeni Alwis; Yu Qiu; Benjamin Blount;
Center for Disease Control and Prevention, Chamblee, GA
WP 026 Simultaneous Analysis of Alkylphenol Ethoxylates
Using Ultra-High Speed LC-MS/MS; Daisuke Kasai1; Jun
Watanabe2; Keiko Matsumoto2; Koji Takinami1; 1Nissenken
Quality Evaluation Center, Tokyo, Japan; 2Shimadzu
Corporation, Kyoto, Japan
WP 027 Determination of Ten Nitrosamines in Drinking Water
by Gas Chromatography/Electron Ionization Tandem
Mass Spectrometry; Peng Gao1; Jun Fan1; Changqing
Lin2; 1Shimadzu (China) Co.,Ltd, Shanghai, China; 2Putuo
Environmental Monitoring Station,Shanghai, Shanghai, China
WP 028 Analysis of Linear Alkylbenzene Sulfonate in
Environmental Water Using Online SPE LC System
Coupled with LC-MS/MS; Benjamin Figard1; Keiko
Matsumoto2; Jun Watanabe2; Yoshihiro Hayakawa2;
1
Shimadzu Scientific Instruments,INC., Columbia, MD;
2
Shimadzu Corporation, Kyoto, Japan

PAGE 120					

WP 029 From Source Water to Tap Water to Swimming Pool and
Spa Water: Effects of Disinfectants and Implications
for Exposure/Toxicity; Eric Daiber1; Susan Richardson1;
Sridevi Anduri1; David DeMarini2; Ernest Blatchley3;
Mehrnaz Afifi3; 1US EPA, NERL, Athens, GA; 2U.S. EPA,
NHEERL, RTP, NC; 3Purdue University, West Lafayette, IN
WP 030 A Comparison of the Use of Online SPE and Large
Volume Injection Using LC-MS/MS for the Detection of
Environmental Contaminants; Stephen J. Lock; Pamela
Stoddart; ABSCIEX, Warrington, UK
WP 031 Reliable Analysis of Priority Pollutants in Water by
GC/HRMS with Faster, Cheaper, and Safer Sample
Preparation; Olga Polyakova1; Dmitry Mazur1; Slava
Artaev2; Albert T. Lebedev1; 1Moscow State University,
Moscow, Russian Federation; 2Leco Corporation, St.
Joseph, MI
WP 032 Solid Phase Micro-extraction (SPME) with Gas
Chromatography/Mass Spectrometry (GC/MS) to
Quantify Polar Haloamides in Drinking Water; Brandon
Jessie; Christine N. Dalton; Carson-Newman College,
Jefferson City, TN
WP 033 Determination of Microcystins in Drinking Water by
Ultra High Performance Liquid Chromatography/Triple
Quadrupole Mass Spectrometry; Jinting Yao; Hongyuan
Hao; Yin Huo; Hengtao Dong; Taohong Huang; Shin-ichi
Kawano; Yuki Hashi; Shimadzu Global COE, Shimadzu
(China) Co., Ltd., Shanghai, China
WP 034 Quantitative Determination of Disinfection Byproduct
Haloacetic Acids in Drinking Water Using Liquid
Chromatography Tandem Mass Spectrometry; Jinyuan
Wang1, 2; Xiaodong Liu1, 2; Jonathan Beck1, 2; Charles
Yang1, 2; Guifeng Jiang1, 2; Richard Jack1, 2; 1Thermo Fisher
Scientific, San Jose, CA; 2Thermo Fisher Scientific,
Sunnyvale, CA
WP 035 N-nitrosodimethylamine (NDMA) Analysis in Water
Using GC Triple Quadrupole Mass Spectrometry in
Positive Chemical Ionization Mode; Anthony Macherone2;
Alandra Kahl1; Darryl Jones1; Lisa Lowe1; Shane Snyder1;
1
University of Arizona, Tuscon, AZ; 2Agilent Technologies,
Wilmington, DE
Environmental Analysis: Hydrocarbons and DOM, 036 – 044
WP 036 Sulfur Rich Crude Oil and Bitumen Analysis on
the Molecular Level by APPI and LDI FT-ICR Mass
Spectrometry; Matthias Witt; Jochen Friedrich; Bruker
Daltonik GmbH, Bremen, Germany
WP 037 Dissolved Organic Matter in Lake Superior: A Study
Combining Characterization by ESI FT-ICR MS, UVVisible Spectroscopy and Isotopic Analysis; Hongyu
Li; Elizabeth Minor; Large Lakes Observatory,University of
Minnesota, Duluth, MN
WP 038 Integrated Alkane, PAH, and Petroleum Biomarker
Analysis by Tandem GC/MS; Stephan Baumann; Agilent
Technologies, Inc., Santa Clara, CA
WP 039 Applying Differential Mobility Spectrometry with
Unique Gas-Phase Separations to the Analysis of
Naphthenic Acids; J. Larry Campbell1; Takeo Sakuma1;
Andre Schreiber1; Paul Winkler1; John V. Headley2; Kerry
M. Peru2; 1AB SCIEX, Concord, Canada; 2Water Sci. Tech.
Directorate, Environment Canada, Saskatoon, SK, Canada
WP 040 GCxGC Profiling of Naphthenic Acid Esters in Oil Sands
Composite Tailings; David Bowman1; David Alonso2; Lorne
Fell2; Joe Binkley2; Brian McCarry1; 1McMaster University,
Hamilton, Canada; 2Leco Corporation, St Joseph, Mi

61ST ASMS CONFERENCE ON MASS SPECTROMETRY

WEDNESDAY POSTERS

WP 041 Characterization of Carbonaceous Particulate Matter
Using Thermal Extraction Followed by Pyrolysis
with Gas Chromatography Mass Spectrometry; Alena
Kubatova; Josef Beranek; Richard Cochran; Haewoo
Jeong; Evguenii Kozliak; University of North Dakota, Grand
Forks, ND
WP 042 Characterization of 2.5 Micron Particulate Borne
Semivolatile Organic Compounds by GCxGC-TOFMS
and UHPLC-Orbitrap MS – Method Development,
Performance and Applications; Paul Yang1; Nicholas
Karellas1; Adrienne Boden1; Xiaoming Zhao1; Mike
Spencer1; Chunyan Hao1; Stephanie Lemanik1; Gerald
Ladwig1; Charles Yang2; Kristi Akervik2; Maciej Bromirski2;
Dipankar Ghosh2; 1Ministry of the Environment, Etobicoke,
Canada; 2Thermo Scientific, San Jose, CA
WP 043 Calibration of a Membrane Inlet Mass Spectrometer for
Environmental Monitoring; Simon Maher; Boris Brkic;
Stephen Taylor; University of Liverpool, Liverpool, UK
WP 044 Detection of Nitrated and Oxygenated Polycyclic
Aromatic Hydrocarbons Using Atmospheric
Pressure Chemical Ionization High Resolution Mass
Spectrometry; Richard Cochran; Alena Kubatova;
University of North Dakota, Grand Forks, ND
Energy: Hydrocarbons and Petrochemical, 045 – 069
WP 045 Oil Spill Source Identification by Principal Component
Analysis of Electrospray Ionization Fourier Transform
Ion Cyclotron Resonance Mass Spectra; Yuri E.
Corilo1, 2; David C. Podgorski1, 2; Amy M. McKenna1, 3;
Ryan P. Rodgers1, 2; Karin L. Lemkau4; Christopher M.
Reddy4; Alan G. Marshall1, 3; 1National High Magnetic
Field Laboratory - FSU, Tallahassee, FL; 2Future Fuels
Institute - FSU, Tallahassee, FL; 3Department of Chemistry
and Biochemistry - FSU, Tallahassee, FL; 4Woods Hole
Oceanographic Institute, Woods Hole, MA
WP 046 Improved Relative Abundance and Overall Sensitivity
by Optimized Modifier/Analyte Concentration in
Positive Ion Electrospray Crude Oil FT-ICR-MS; Brian M.
Ruddy1; Christopher L. Hendrickson2; Alan G. Marshall1, 2;
Ryan P. Rodgers1, 2; 1Florida State University, Tallahassee,
FL; 2National High Magnetic Field Laboratory, Tallahassee,
FF
WP 047 Development of High-Field Orbitrap FTMS-based
Platform for Petroleum Analysis; Konstantin O. Zhurov;
Anton N. Kozhinov; Yury O. Tsybin; Ecole Polytechnique
Fédérale de Lausanne, Lausanne, Switzerland
WP 048 Characterization of Petroleum Fractions Using Mass
Spectrometry Tools; Hung Pham1; Haiyan Wang1; Howard
Greenberg1; Matthew Unterfenger1; Wayne Rathbun1;
Jonathan Pierson1; Paul Adams1; Gil Jones1; Kendall
Guyer1; Dave Hindenlang2; 1UOP LLC, A Honeywell
Company, Des Plaines, IL; 2Honeywell International Inc.,
Morristown, NJ
WP 049 FT-ICR-MS – Studying the Effects of Ion Suppression
on Crude Oil Mass Spectral Response Using Standard
Compounds and Systems; Melisa Brown; Ning
Sanguantrakun; Ken Chanthamontri; Thomas Oldenburg;
Steve Larter; PRG, University of Calgary, Calgary, Canada
WP 050 Petroleomics at Moderate Mass Resolution; Fan Huang;
Kermit K. Murray; Louisiana State University, Baton Rouge,
LA
WP 051 Ionization of Hydrocarbons by Atmospheric Solid
Analysis Probe (ASAP) and Atmospheric Pressure
Gas Chromatography (APGC); Chunping Wu; Kuangnan
Qian; Kathleen Edwards; Clifford Walters; Anthony
Mennito; Christopher Jurtschenko; ExxonMobil Research &
Engineering Co., Annandale, NJ

WP 052 Comparisons and Characterization of Different
Asphaltenes Using Novel Ion Mobility-Mass
Spectrometry Comparison Software ; Eleanor Riches1;
Jeremie Ponthus2; 1Waters Corporation, Manchester, UK;
2
IFP Energies Nouvelles, Lyon, France
WP 053 Isolation and Characterization of Interfacial Material
from Athabasca Bitumen by Ultrahigh Resolution FTICR Mass Spectrometry; Amy Clingenpeel1; Jacqueline
Jarvis1; Winston Robbins2; Alan Marshall1, 3; Ryan Rodgers1,
3 1
; Florida State University Department of Chemistry,
Tallahassee, FL; 2Consultant, Brunswick, ME; 3Ion Cyclotron
Resonance Program, NHMFL, Tallahassee, FL
WP 054 Comparing LDI-FT-ICR and LDI-TOF/TOF Mass
Spectrometry to Characterize Vacuum Residue of
Colombian Crude Oils; Enrique Mejía-Ospino1; Rafael
Cabanzo1; Jorge Armando Orrego-Ruiz2; Andrea Gómez2;
Yustina Rodriguez2; 1Universidad Industrial de Santander,
Bucaramanga, Colombia; 2Instituto Colombiano de
Petróleos (ICP-Ecopetrol), Piedecuesta, Colombia
WP 055 Asphaltene Analysis by TLC MALDI-TOF-MS; Martha
L. Chacón1; Andrea Gómez-Escudero2; Cristian BlancoTirado1; Marianny Y. Combariza1; 1Escuela de Química,
Univ Industrial de Santander, Bucaramanga, Colombia;
2
Instituto Colombiano del Petróleo, Ecopetrol, Piedecuesta,
Colombia
WP 056 A CAD Study on Ionized Model Compounds of
Asphaltenes Containing Varying Alkyl Side Chains and
Different Aromatic Core Sizes; Mohammad Sabir Aqueel;
James Riedeman; Hilkka Kenttamaa; Purdue University,
Westlafayette, IN
WP 057 Examination of Solvent/Reagent Effects on Collisionally
Activated Dissociation of Ionized Asphaltenes Using
Atmospheric Pressure Chemical Ionization; Matthew
Hurt; Priya Murria; Hilkka Kenttamaa; Purdue University,
West Lafayette, IN
WP 058 Structural Comparison of Asphaltenes of Different
Origins by Using Tandem Mass Spectrometry; Weijuan
Tang; Purdue University, West Lafayette, IN
WP 059 Characterization of Nitrogen Containing Compounds
in Vacuum Gas Oils Resins by ESI FT-ICR MS and HTGCxGC/MS; Laure Boursier1; Jérémie Ponthus 1; Vincent
Souchon1; Cyril Dartiguelongue1; Didier Thiébaut2; 1IFP New
Energy, Solaize, France; 2UMR 7195 PESCA - ESPCI Paris
Tech, Paris, France
WP 060 Quantitative Analysis of Long Chain Fatty Acids
Present in a Type I Kerogen Using ESI-FT-ICR-MS and
Compared With GC-FID; Albert W. Kamga1; Francoise
Behar2; Patrick G. Hatcher1; 1Department of Chemistry and
Biochemistry, ODU, Norfolk, VA; 2TOTAL, Paris, France
WP 061 Quantitation of Asphaltene Inhibitors in Crude Oil by
LC-TOF MS; Steven Rowland1; Winston Robbins3; Ryan
Rodgers1, 2; 1Florida State University, Tallahassee, FL;
2
National High Magnetic Field Laboratory, Tallahassee, FL;
3
Future Fuels Institute, Tallahassee, FL
WP 062 High-Throughput Analysis Method for Straight Chain
Alkanes Using LDTD-MS/MS; Pascal Belisle; Gregory
Blachon; Annick Dion; Serge Auger; Pierre Picard; Phytronix
Technologies, Quebec City, Canada
WP 063 Targeted Petroleomics: Using High-Resolution TOF-MS
to Evaluate the Efficiency of Acid and Sulfur Compound
Removal from Crude Oil; Kevin Siek1; Julie Hernández2;
Clécio Klitzke3; Joe Binkley1; Jeffrey S. Patrick1; Rubens
Maciel-Filho2; Marcos Eberlin3; 1LECO Corporation, Saint
Joseph, MI; 2UNICAMP Separation Process Development
Laboratory, Campinas SP, Brazil; 3Thomson Mass
Spectrometry Laboratory UNICAMP, Campinas SP, Brazil

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WP 064 Characterization of Heteroatom-Containing Aromatics
in Crude Oil on a Research-Type High-Field Orbitrap MS
by Utilization of a Deuterated Derivatization Reation;
XuXiao Wang; Wolfgang Schrader; Max-Planck Inst für
Kohlenforschung., Mülheim / Ruhr, Germany
WP 065 Identification of Sulfur Compounds in Petroleum
Samples Using Derivatization with Mass Deficient
Reagents; Ting Wang1; Daniel Jupiter2; Laxman Devkota1;
Kevin Chambliss1; Kevin Pinney1; Touradj Solouki1; 1Baylor
Univerisy, Waco, TX; 2Texas A&M Health and Science
Center, Temple, TX
WP 066 Geotracers by FT-ICR MS; Hendrik Muller1; Khaled Arouri2;
Saroj Panda1; Adnan Al-Hajji1; 1Research and Development
Center, Saudi Aramco, Dhahran, Saudi Arabia; 2EXPEC
Advanced Research Center, Saudi Aramco, Dhahran, Saudi
Arabia
WP 067 Petroleum Biomarkers Analyzed by Atmospheric
Pressure Gas Chromatography Tandem Mass
Spectrometry (APGC/MS/MS); Douglas Stevens1; Quan
Shi2; Chang Samuel Hsu3, 4; 1Waters Corporation, Milford,
MA; 2China University of Petroleum, Beijing, China; 3Florida
State University, Tallahassee, FL; 4Petro Bio Oil Consulting,
Tallahassee, FL
WP 068 Investigating Polyaromatic Sulfur Heterocycles in
Model Systems and Crude Oil Using Atmospheric
Pressure Chemical Ionization Orbitrap Mass
Spectrometry; Nadim Hourani1; Ma’an Amad1; Jan
Andersson2; Mani Sarathy1; 1King Abdullah University Of
Science and Technology, Thuwal, Saudi Arabia; 2University
of Muenster, Muenster, Germany
WP 069 An Approach to Analysis and Visualization of Crude
Oil Samples; Manhoi Hur1; Yunju Cho2; Sungwhan Kim2;
Eve Syrkin Wurtele1; 1Iowa State University, Ames, IA;
2
Kyungpook National University, Daeku, South Korea
Small Molecules: Quantitative Analysis III, 070 – 097
WP 070 Method Development and Validation of an Assay for
the Quantitation of Balsalazide in Human Plasma by
Basic Reversed-Phase LC-MS/MS; Melissa Meyer; Sara
Clemens; Nancy Zheng; Zong-Ping Zhang; PPD, Middleton,
WI
WP 071 High Sensitivity and Low Sample Volume Method
Development for Quantitation of Fluticasone Propionate
and Salmeterol in Human Plasma by LC-MS/MS; Nancy
Zheng; Jun Wang; Zong-Ping Zhang; PPD Inc, Middleton,
WI
WP 072 Simultaneous Determination of Pioglitazone and
Celecoxib in Mouse Plasma by nanoLC-MS; Hong
Wang1; Hiroyuki Katayama1; Mark Schliekelman2; Sam
Hanash1; 1MD Anderson Cancer Center, Houston, TX; 2Fred
Hutchinson Cancer Research Center, Seattle, WA
WP 073 Development of a Mass Spectrometric Method for
Quantitating Sex Steroids in Human Serum; Kerry M.
Wooding; Chris A. Johnson; Joseph A. Hankin; Robert M.
Barkley; Andrew P. Bradford; Nanette Santoro; Robert C.
Murphy; University of Colorado Denver AMC, Aurora, CO
WP 074 Determination of Abiraterone in Human Plasma by LCMS/MS; Lan Li; Yuan-Shek Chen; Kumar Ramu; QPS, LLC,
Newark, DE
WP 075 Quantitative Determination of Irsogladine in Human
Plasma by Liquid Chromatography-Tandem Mass
Spectrometry; Haejong Jang; Yuchang Choi; Kyunghwan
Kim; Seungwoo Kang; International Scitntific Standard,
Chuncheon, South Korea

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WP 076 A Validated Method for the Determination of Adefovir in
Human Plasma by Liquid Chromatography-Electrospray
Ionization Tandem Mass Spectrometry; Won Seok Nam;
Seo Hyun Yoon; Kyung-Sang Yu; In-Jin Jang; Joo-Youn
Cho; Seoul National University College of Medicine, Seoul,
South Korea
WP 077 A Sub-Picogram LC-MS/MS Method for the Analysis
of Mometasone Furoate in Human Plasma; Veniamin
Lapko; Alan Dzerk; Karl Linderholm; Roger Coe; Brandon
Retke; Mike Merrill; Curtis Sheldon; Celerion, Inc, Lincoln,
NE
WP 078 Simultaneous Quantification of 15 Drugs of Abuse
in Oral Fluid and Plasma by Ultra High Performance
Liquid Chromatography/Tandem Mass Spectrometry;
Yuling Song; Jinting Yao; Xiongxiong Qiu; Taohong Huang;
Shin-ichi Kawano; Yuki Hashi; Shimadzu (China) Co., LTD,
Shanghai, China
WP 079 Sensitive LC-MS/MS Quantitation of Thyroid Hormones
in Serum; Changtong Hao; Hui Qiao; Chuck Jolliffe; Sha
Joshua Ye; IONICS Mass Spectrometry, Bolton, ON, Canada
WP 080 Highly Sensitive LC-MS/MS Quantification of
Underivatized 1a,25-dihydroxyvitamin D3 Comparing
Various Sample Extraction Methods; Sha Joshua Ye;
Changtong Hao; Hui Qaio; IONICS Mass Spectrometry,
Bolton, ON Canada
WP 081 Developing High Throughput 2D-LC-MS/MS Method
for Quantification of Vitamin D which Overcomes
Challenges of Chemiluminescent Immunoassay;
Sreekala Narayanan1; Anura .V Kurpad1; Siji Joseph2;
Sudha Rajagopalan2; Amit Kumar Mandal1; Suresh Babu
C.V2; 1St. John’s Research Institute, Bangalore, India;
2
Agilent Technologies, Bangalore, India
WP 082 Development and Validation for the Determination of
(E)-/(Z)-vitamin K1 Isomers in Human Plasma by LC-MS/
MS; Jingguo Hou; Melvin Tan; Ravi Orugunty; Xiaodong
Zhu; Thomas Horvath; Jing Zhou; Gregory Poch; Michael
Sullivan; Edward Wells; Steve Unger; WWCT, Austin, TX
WP 083 UHPLC-MS-MS Quantitation of Flavonoids, Terpene
Lactones, and Detection of Unwanted Pesticides and
Pharmaceuticals in Ginkgo Biloba Natural Dietary
Products; Frederic L Ciner1; Thomas Hayes1; Rachel
Lieberman2; Jeffrey Dahl2; 1Shimadzu Scientific Instruments,
SOE, Raleigh, NC; 2Shimadzu Scientific Instruments,
Columbia, MD
WP 084 An Alternative USP Method for the Analysis of
Impurities in Riboflavin (Vitamin B2) Using LC-MSMS; Nicolas J. Hauser1; Jenna E. Milliken2; Carmen
T. Santasania3; 1RTC/Sigma-Aldrich, Laramie, WY;
2
Department of Chemistry, University of Wyoming, Laramie,
WY; 3Supelco/Sigma-Aldrich, Bellefonte, PA
WP 085 Application of DBS for the Quantitative Determination
of Midazolam and Hydroxymidazolam Using an AB
Sciex 6500 QTrap LC-MS/MS System; Alexandre
Pimenov; Jeffry Plomley; Mohamed Makhloufi; Charles
River Laboratories, Senneville, Canada
WP 086 Automatic LC/MS/MS Method to Quantitate
Eicosapentaenoic acid (EPA) in Rat Plasma; Rachel Sun;
Jordan Nally; Tim Shoaf; BASi, West Lafayette, IN
WP 087 Quantification of Midazolam and 1-Hydroxymidazolam
in Human Plasma Using API-4000 LC-MS/MS Systems
with Higher Specificity and Lower Background Noise;
Guangchun Zhou; Nicole Roenker; Yong-Xi Li; Medpace,
Cincinnati, OH
WP 088 A Simple, Direct Quantification of Carboplatin in Human
Plasma Using Liquid Chromatography-Tandem Mass
Spectrometry; Tian-Sheng Lu; Elise Malinowski; Nicole
Roenker; Yong-Xi Li; Medpace, Cincinnati, OH

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WEDNESDAY POSTERS

WP 089 A Robust LC-MS/MS Analytical Method for
Quantification of β-Lapachone: A Novel
Chemotherapeutic Agent for the Treatment of Solid
Tumors; Claudia Meek1; Erling Beck1; David Boothman2;
David Gerber2; Richard Leff1; 1School of Pharmacy, Texas
Tech University HSC, Dallas, TX; 2Harold C. Simmons
Cancer Center, UT Southwestern, Dallas, TX
WP 090 Two-Dimensional Liquid Chromatography/In-Source
Fragmentation and Tandem Mass Spectrometry for
Quantification of 2-Hydroxypropyl-β-Cyclodextrin in
Human Plasma; Xuntian Jiang; Hui Jiang; Rohini Sidhu;
Jean E Schaffer; Daniel S Ory; Washington University, St.
Louis, MO
WP 091 Determination of Leelamine in Mouse Plasma by
Liquid Chromatography/Electrospray Tandem Mass
Spectrometry; Min Song; Miri Hong; Oh Kwang Kwon;
Doohyun Lee; Suyoun Lee; Taeho Lee; Sangkyu Lee;
Kyungpook National University, Daegu, Korea
WP 092 Development of a HPLC–MS/MS Assay to Measure
Irinotecan and Its Main Metabolites in Plasma.
Preliminary Pharmacokinetic Evaluation in Cancer
Patients; Elena Marangon; Elisa Mazzega; Giuseppe
Toffoli; National Cancer Institute of Aviano, Aviano, Italy
WP 093 Determination of Ceftiofur Metabolite Desfuroylceftiofur
Cysteine Disulfide in Bovine Ileum by LC-MS/MS;
Gajendiran Mahadevan; Shixia Feng; Oscar A. Chiesa;
Center for Veterinary Medicine, FDA, Laurel, MD
WP 094 Development and Validation of a Sensitive LC-MS/MS
Method for Analysis of Midazolam and Their Metabolites
in Human Plasma and Urine; Ganesh Moorthy; Praveen
Srivastava; Vu Nguyen; Jeffrey Barrett; Athena Zuppa; The
Children’s Hospital of Philadelphia, Philadelphia, PA
WP 095 Rapid and Robust Analysis Method for Quantifying
Antidepressants and Major Metabolites in Human
Serum by UHPLC-MS/MS; Vincent Goudriaan1; Christ
Pijnenburg2; Jacob Diepenbroek2; Jan Giesbertsen2;
Annemieke Vermeulen Windsant-v.d. Tweel2; 1Shimadzu
Benelux BV, ‘s-Hertogenbosch, Netherlands; 2ZANOB BV,
‘s-Hertogenbosch, Netherlands
WP 096 Quantitative Determination of Ultralow Level of
Azelastine and Its Metabolite, Desmethylazelastine in
Human Plasma via Two-Dimensional HPLC with MS/
MS Detection; Jingduan Chi; Zong-Ping Zhang; PPD Inc,
Madison, WI
WP 097 Development a UHPLC-MS/MS Method for
Determination of Clopidogrel, Clopidogrel Acid, and
Clopidogrel Active Metabolite H4 in Human Plasma;
Wenyi Hua; Michael Lesslie; Brian T. Hoffman; Daniel
Mulvana; Advion Bioanalytical Labs, a Quintiles Company,
Ithaca, NY
Diagnostic Clinical Chemistry: Small Molecules II, 098 – 116
WP 098 Sensitive Assay of Free Thyroid Hormones by Online
SPE-UHPLC-MS/MS in Human Plasma; Maureen Ramero;
Stéphane Moreau; Mikael Levi; Shimadzu France, Noisiel,
France
WP 099 Quantification of Testosterone from Dried Blood
Spots Using Liquid Chromatography Tandem Mass
Spectrometry; Richard E. Mathieu1; Catherine P. Riley1;
Carmen L. Wiley1, 2; 1Pathology Associates Medical
Laboratories, Spokane, WA; 2Providence Sacred Heart
Medical Center, Spokane, WA
WP 100 LC-ESI-MS/MS Multi-Target Quantification Method of
Derivatized Catecholamines and Serotonin Applied to
Clinical Analysis; Elias Tessaro1, 2; Giovana Bataglion1;
Phellipe Amaral1, 2; Gianfranco Zampieri3; Diogo Baldim3;

UNICAMP, Campinas, Brazil; 2LABMASS Laboratory,
Campinas, Brazil; 3Salomão & Zoppi Diagnósticos, São
Paulo, Brazil
Simultaneous Analysis of Urinary Metanephrines,
Catecholamines and Serotonin by ESI-LC-MS/MS with
Solid Phase Extraction Sample Preparation; Murat Celik;
Hasan Ozgen; Avni Cavdar; Zivak Technologies, Kocaeli, Turkey
Sensitive Liquid Chromatography Mass Spectrometry
Method for measuring Plasma Metanephrines;
Catherine Riley1; Richard E. Mathieu1; Carmen L. Wiley1, 2;
1
Pathology Associates Medical Laboratories, Spokane, WA;
2
Providence Sacred Heart Medical Center, Spokane, WA
Use of a 2 μm Ultra High Performance Liquid
Chromatography Column and High Resolution MS
in the Clinical Laboratory; Ling Bei1; Michael Schulz1;
Petra Lewits1; Patrik Appelblad1; Hans-Ake Lakso2; Joern
Schneede2; 1EMD Millipore, Billerica, MA; 2Dep Clinical
Pharmacology Umeå University Hospital, Umeå, Sweden
Diagnosis of Breast Cancer Based on Lipid Profiles
Obtained by MALDI-TOF Mass Spectrometry; Hung Su1;
Ya-Fei Bao1; Yi-Tzu Cho2; Jentaie Shiea 1; Pei-Yung Nien3;
Ya-Hui Chang3; Ming-Feng Hou3; 1National Sun Yat-Sen
Univ., Kaohsiung, Taiwan; 2Yuh-Ing Junior College of Health
Care & Management, Kaohsiung, Taiwan; 3Kaohsiung
Medical University Hospital, Kaohsiung, Taiwan
Development of a Method for the Diagnosis of
Adrenoleukodystrophy Using Liquid ChromatographyMass Spectrometry; Kazuhiro Kida1; Hideki Nakajima1;
Teruhiko Miwa1; Jun Watanabe2; Teruhisa Shiota3; Torayuki
Okuyama1; Masafumi Onodera1; Junichiro Fujioto1; 1National
Center for Child Health and Development, Tokyo, Japan;
2
Shimadzu Corporation, Kyoto, Japan; 3AMR, Inc., Tokyo, Japan
Determination of Polyalcohols (polyols) in Urine
by Gas Chromatography-Chemical Ionization Mass
Spectrometry; Charles Kroll; Mark Magera; Perry Loken;
Brenda Holmen; Dietrich Matern; Dimitar Gavrilov; Silvia
Tortorelli; Devin Oglesbee; Piero Rinaldo; Kimiyo Raymond;
Mayo Clinic, Rochester, MN
Mucopolysaccharide Quantitation in Urine by LC-MS/
MS; Jean M Lacey; Mark J Magera; Dimitar K Gavrilov;
Silvia Tortorelli; Devin Oglesbee; Piero Rinaldo; Kimiyo M
Raymond; Dietrich Matern; Mayo Clinic, Rochester, MN
Clinical Diagnostics Approaches of Lysosomal Storage
Diseases on DBSs by Fluorimetry and MRM-MS Using
Identical α-hydroxy-coumarin based substrates; Claudia
Cozma 1; Marius- Ionut Iurascu1; Gabriela Paraschiv1; Laura
Ion2; Alina Brandusa Petre2; Adolf Mühl3; Stefan Maeser3;
Michael Przybylski1; 1University of Konstanz, Konstanz,
Germany; 2Al.I. Cuza University, Iasi, Romania; 3Centogene
AG, Freiburg & Rostock, Germany
Nicotine and Metabolites: Evaluation of Supported
Liquid Extraction Approaches prior to UPLC-MS/MS
Analysis; Alan Edgington1; Lee Williams1; Adam Senior1;
Rhys Jones1; Helen Lodder1; Geoff Davies1; Steve Jordan1;
Claire Desbrow1; Gavin Jones1; Victor Vandell2; Frank Kero2;
1
Biotage GB Limited, Cardiff, UK; 2Biotage US, Charlotte, NC
Fast On-Line SPE-UHPLC-MS/MS Quantitative
Analysis of Multiclass Antibiotics in Human Plasma for
Emergency Diagnostic; Mikaël LEVI; Maureen Ramero;
Stephane Moreau; Shimadzu France, Marne La Vallee
Cedex 2, France
Quantification of Serum Voriconazole by Liquid
Chromatography and Tandem Mass Spectrometry;
Karina Helena Morais Cardozo; Jessica Silva Salgueiro;
Valdemir Melechco Carvalho; Fleury Group, São Paulo,
Brazil
1

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WP 116

Concentrations of Arsenic in Human Urine: A
Correlation between Total Arsenic by ICP-MS and
Speciated Arsenic by HPLC-ICP-MS; Indranil Sen; Wei
Zou; CA Dept of Public Health, Richmond, CA
Comparison of Two Sample Preparation Methods for
Analyzing Pain Management Drugs in Urine; Xuejun
Zang; Igor Gavin; Krishna Mallia; Asha Oroskar; Anil
Oroskar; Orochem Technologies Inc., Lombard, IL
An Enzyme Assay Mass Screening System for
Adenosine Deaminase Deficiency from Dried Blood
Spots Using a DART MS/MS; Hideki Nakajima1;
Teruhiko Miwa1; Kazuhiro Kida1; Jun Watanabe2; Teruhisa
Shiota3; Torayuki Okuyama1; Masafumi Onodera1;
Junichiro Fujimoto1; 1National Center for Child Health and
Development, Tokyo, Japan; 2Shimadzu Corporation, Kyoto,
Japan; 3AMR, Inc., Tokyo, Japan
Positive and Negative Mode PESI-MS for Cancer
Diagnostics; Mridul Kanti Mandal1; Kentaro Yoshimura2;
Subhrakanti Saha1; Md. Obaidur Rahman1; Yasuo Shida1;
Sen Takeda2; Hiroshi Nonami3; Kenzo Hiraoka1; 1CERC,
University of Yamanashi, Kofu, Japan; 2Faculty of Medicine,
University of Yamannashi, Chuo, Japan; 3Faculty of
Agriculture, Ehime University, Matsuyama, Japan
Catalytic Pyrolysis Metal Oxide Laser Ionization
(CP-MOLI MS) Fatty Acid Profiling for Bacterial
Identification; Kirk Jensen1; Casey McAlpin1; Christopher
Cox1; Robert Cody2; Jon Rees3; Kent Voorhees1; 1Colorado
School of Mines, Golden, CO; 2JEOL USA, Peabody, MA;
3
Centers for Disease Control, Atlanta, GA

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Forensics - Drugs of Abuse, 117 – 135
Method Scalability for Drugs of Abuse Extraction from
Urine using Supported Liquid Extraction prior to UPLCMS/MS Analysis; Lee Williams1; Rhys Jones1; Adam
Senior1; Helen Lodder1; Geoff Davies1; Kerry Stephens1;
Steve Jordan1; Gavin Jones1; Claire Desbrow1; Victor
Vandell2; Frank Kero2; 1Biotage GB Limited, Cardiff, UK;
2
Biotage, Charlotte, NC
WP 118 High Performance Cost Efficient LC-MS/MS Solution
for NIDA-5 Panel Using New Dual Channel Prelude
SPLC System and Quantum-Ultra Mass Spectrometer;
Haiqiang Yu; Kristine Van Natta; Marta Kozak;
ThermoFisher Scientific, San Jose, CA
WP 119 Direct Mass Imaging of Ketamine Distribution in Single
Scalp Hair by MALDI-CASI-FTMS; Ping Xiang1; Hai Pu2;
Min Shen1; 1Institute of Forensic Sciences, Shanghai,
China; 2Bruker, Beijing, China
WP 120 A Reversed-Phase LC-MS/MS Method for the
Quantitation of Ethyl Glucoronide and Ethyl Sulfate
in Human Urine; Frances Carroll; Sharon Lupo; Chris
Denicola; Ty Kahler; Paul Connolly; Restek Corporation,
Bellefonte, PA
WP 121 Rapid Screening and Semi-Quantitative Analysis for
Forensic Drugs in Blood Using Liquid Chromatography
Triple Quadrupole Mass Spectrometry; Thomas Hayes1;
Keiko Kudo2; Toshikazu Minohata3; Kiyotaka Usui4; Noriaki
Shima5; Munehiro Katagi5; Hitoshi Tsuchihasi6; Koichi
Suzuki6; Ichiro Hirano3; Noriaki Ikeda2; 1Shimadzu Scientific
Instruments, Inc., Columbia, MD; 2Kyushu University,
Fukuoka, Japan; 3Shimadzu Corporation, Kyoto, Japan;
4
Tohoku University Graduate School of Medicine, Sendai,
Japan; 5Osaka Prefectural Police, Osaka, Japan; 6Osaka
Medical Collage, Takatsuki, Japan
WP 122 Direct Analysis Using Paper-Spray Mass Spectrometry:
Method Development for the Rapid Screening of Drugs
of Abuse for Forensic Toxicology; Maria C. Prieto
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Conaway 1; Nicholas E. Manicke2; Marta Kozak1; 1Thermo
Fisher Scientific, San Jose, CA; 2Purdue University, West
Lafayatte, IN
Characterization and Classification of Heroin from
Illicit Heroin Seizures by GC/Q-TOF; Dmitry Koluntaev1;
Sergei Syromyatnikov2; Igor Sarychev2; Sofia Aronova3;
1
InterLab, Inc., Moscow, Russia; 2Federal Drug Control
Service of Russian Federation, Moscow, Russia; 3Agilent
Technologies, Inc., Santa Clara, CA
Cocaine and Metabolites: Method Development
Strategies Using Supported Liquid Extraction from
Urine Prior to UPLC-MS/MS Analysis; Rhys Jones1; Lee
Williams1; Adam Senior1; Helen Lodder1; Geoff Davies1;
Kerry Stephens1; Steve Jordan1; Gavin Jones1; Claire
Desbrow1; Victor Vandell2; Frank Kero2; 1Biotage GB
Limited, Cardiff, UK; 2Biotage, Charlotte, NC
Rapid and Sensitive Quantitation of THC and
Metabolites in Urine by Microflow LC-MS/MS; Daniel
Blake1; Julie Moriceau1; Sylvain Dulaurent2; Jean-Michel
Gaulier2; Aymeric Morla1; 1AB SCIEX, Warrington, UK;
2
CHU Dupuytren Limoges, Limoges, France
Direct Quantification of 11-nor-Δ9-tetrahydrocannabinol9-carboxylic Acid and Its Glucuronide in Urine Using
Liquid Chromatography-Tandem Mass Spectrometry;
Jin-Young Kim; Woonyong Kwon; SungIll Suh; Moon Kyo
In; Supreme Prosecutors’ Office, Seoul, Korea
Ultrafast, Ultra-selective High-Throughput Forensic
Drug Screening in Urine Using SPE/MS/MS; Vaughn
Miller; Michelle Romm; Kari Schlicht; Nikunj Parikh;
Mohamed Youssef; Maxcy Stroman; William LaMarr; Can
Ozbal; Agilent Technologies, Wakefield, MA
Rapid LC-MS/MS Screening Method for Fourteen JWHtype Synthetic and Natural Cannabinoids in Counterfeit
Samples; Philippe Lebel; Karen C. Waldron; Alexandra
Furtos; Université de Montréal, Montréal, Canada
Rapid Generation of Synthetic Cannabinoids’
“Metabolite Fingerprints” following Human Hepatocyte
Metabolism and High Resolution Mass Spectrometry
Analysis; Ariane Wohlfarth1; Adarsh Gandhi1; Shaokun
Pang2; Hua-fen Liu2; Mingshe Zhu3; Marilyn Huestis1; 1NIDA,
NIH, Baltimore, MD; 2AB Sciex, Foster City, CA; 3BristolMyers Squibb, Princeton, NJ
Rapid Analysis of Synthetic Cathinones (bath salts)
by LC/Triple Quadrupole Mass Spectrometry; Flaubert
Mbeunkui; Joseph Wiegel; Brent Dixon; Physicians Choice
Laboratory Services, Charlotte, NC
Analysis of Cathinones in Bath Salts by Direct Sample
Analysis TOF MS; Noelle Elliott1; Amanda Leffler2; Avinash
Dalmia1; Frank Dorman2; Carl Schwarz1; 1PerkinElmer,
Shelton, CT; 2Penn State University, University Park, PA
Implementation of Bench-Top Quadrupole Orbitrap
Ultra High Resolution Mass Spectrometer in
Quantitative Analysis of Synthetic Cathinones in Urine
Samples; Marta Kozak; Kristine Van Natta; Shijun Sheng;
Thermo Fisher Scientific, San Jose, CA
Trapping ‘Spice’: A Comprehensive Automated LC-Ion
Trap-MS Screening Approach for the Detection of 38
Synthetic Cannabinoids in Serum; Laura M. Huppertz;
Stefan Kneisel; Volker Auwärter; Jürgen Kempf; Institute of
Legal Medicine, University Freiburg, Freiburg, Germany
Confirmation and Quantification of Synthetic
Cannabinoids in a Sample of “Spice” by GC/TOF-MS;
Chiara Abate1; Ilaria Ferrante1; Luigi Motti2; 1DANI, Cologno
Monzese, Italy; 2Dani SA, Contone, Switzerland

61ST ASMS CONFERENCE ON MASS SPECTROMETRY

WEDNESDAY POSTERS

WP 135 Development of a LC-MS/MS Analytical Strategy Based
on Class-Characteristic Fragmentation Pathways to
Detect Synthetic Cannabinoids in Different Matrices;
Monica Mazzarino; Xavier de la Torre; Ilaria Fiacco;
Francesco Botrè; Antidoping laboratory, Rome, Italy
Imaging MS: Method Development I, 136 – 157
WP 136 Recombinant “IMS TAG” Proteins - A Method for
Validating MALDI - Ion Mobility Separation - Mass
Spectrometry Imaging (MALDI-IMS-MSI); Laura Cole1;
Khaled Mahmoud2; Gillian Tozer3; Simona Francese1; David
Smith1; Malcolm Clench1; 1Sheffield Hallam University,
Sheffield, UK; 2Al-Jouf University, Sakaka, Kingdom of
Saudi Arabia; 3Sheffield University, Sheffield, UK
WP 137 Optimization of A New Method for Spatial Profiling of
N-linked Glycan Expression in Tissues by MALDI Mass
Spectrometry Imaging; Thomas Powers1; E. Ellen Jones1;
Anand Mehta2; Richard R Drake1; 1Medical University
of South Carolina, Charleston, SC; 2Drexel Institute for
Biotechnology and Virology, Doylestown, PA
WP 138 MALDI Imaging Mass Spectrometry (MALDI-IMS)
of Colon Adenocarcinoma Formalin-Fixed ParaffinEmbedded Tissues; Irene (Eirini) Panderi (Panteri) 1, 2; Lulu
Cao2; Lelia Noble2; Kimberly Perez3; Dionysios Pantazatos2;
1
University of Athens, Pharmacy, Pharm.Chemistry, Athens,
Greece; 2COBRE Center for Cancer Research, Brown
Medical, Providence, RI; 3Rhode Island Hospital, Brown
Medical, Providence, RI
WP 139 Identification of Accumulated Ceramide Species in a
Farber Disease Mouse Model by MALDI-MS Imaging;
Shaalee Dworski1; Ellen Jones2; Abdulfatah Alayoubi1;
Jeffrey A. Medin1; Richard Drake2; 1University of Toronto,
Toronto Ontario, Canada; 2Medical University of South
Carolina, Charleston, SC
WP 140 Microwave-Assisted Enzymatic Digestion On-Tissue for
Membrane Protein Analysis with MALDI Imaging Mass
Spectrometry; Jamie L Wenke; Kevin L Schey; Department
of Biochemistry, Vanderbilt University, Nashville, TN
WP 141 The Effect of Heat-Induced Tissue Stabilization on the
MS- and Histo-Architecture of Mouse Brain; Ricardo J.
Carreira1; Cecilia Eriksson2; Walid M. Abdelmoula1; Reinald
Shyti1; René J.M. van Zeijl1; Sandra H. van Heiningen1;
Else A. Tolner1; Arn M.J.M. van den Maagdenberg1; Jouke
Dijkstra1; Per E. Andrén2; Liam A. McDonnell1; 1Leiden
University Medical Center, Leiden, Netherlands; 2Uppsala
University, Uppsala, Sweden
WP 142 Detection of Individual Cells in Tissue Using MALDITOF Imaging at 10 µm Pixel Size; Eckhard Belau1;
Jane-Marie Kowalski2; Janine Rattke1; Alice Ly3; SoerenOliver Deininger1; Detlev Suckau1; Axel Walch3; Marius
Ueffing3; Michael Becker1; 1Bruker Daltonik GmbH, Bremen,
Germany; 2Bruker Daltonics, Billerica, MA; 3HelmholtzZentrum München, Munich, Germany
WP 143 Identifying and Imaging Lipid Oxidation Products
by MALDI-MSn: A Multivariate Approach; Whitney L.
Stutts1; Gert B. Eijkel2; Ron M.A. Heeren2; Richard A. Yost1;
1
Chemistry Department, University of Florida, Gainesville,
FL; 2FOM Institute AMOLF, Amsterdam, NL
WP 144 Peptide Bead Arrays Measured by Mass Spectrometry
Imaging; Vladislav Bergo; Adeptrix Corp, Boston, MA
WP 145 MALDI Imaging of Rat Testis at 10µm Pixel Size and
200k Mass Resolution; Jens Fuchser; Eckhard Belau;
Soeren-Oliver Deininger; Michael Becker; Bruker Daltonik
GmbH, Bremen, Germany

WP 146 Novel Workflow Combining MALDI Imaging and
LC-MALDI for Obtaining Identification and Spatial
Localization of Proteins from Eye Lens Tissue; Sergei
Dikler; Jane-Marie Kowalski; D. Shannon Cornett; Bruker
Daltonics Inc., Billerica, MA
WP 147 Improved Sensitivity in the Detection of Low
Abundance Proteins in Virtual 2D Gels; Karen Lohnes;
Fred Kobzeff; Andrea Rivera; Robert Gunsalus; Joseph
Loo; Rachel Ogorzalek Loo; University of California, Los
Angeles, CA
WP 148 Imaging of Lipids in Rat Heart by MALDI-MS; Shelley
N Jackson; Ludovic M Muller; Kathrine Baldwin; Amina S
Woods; NIDA-IRP, NIH, Baltimore, MD
WP 149 Profiling of a Cell Population Using MALDI Mass
Spectrometry Imaging; Ta-Hsuan Ong; David Kissick;
Stanislav Rubakhin; Jonathan Sweedler; University of
Illinois, Urbana, IL
WP 150 Separation Effects Caused by the Dried-Droplet Sample
Preparation for MALDI Mass Spectrometry of Synthetic
Polymers; Stefan Johannes Gabriel1; Steffen Weidner1;
Ulrich Panne1; Clemens Schwarzinger2; 1Federal Institute
for Material Research BAM, Berlin, Germany; 2Johannes
Kepler University JKU, Linz, Austria
WP 151 Matrix Application Method Optimization for MALDIMS Imaging (MSI) of Metabolites during Nitrogen
Fixation in the Medicago truncatula–Sinorhizobium
meliloti Symbiosis; Erin Gemperline1; Vivian Hui Ye2;
Muthusubramanian Venkateshwaran3; Jean-Michel Ané3;
Lingjun Li1, 2; 1UW-Madison Department of Chemistry,
Madison, WI; 2UW-Madison School of Pharmacy, Madison,
WI; 3UW-Madison Department of Agronomy, Madison, WI
WP 152 Towards 3-Dimensional MALDI MS Molecular Imaging
of the Optic Chiasm; David M. G. Anderson1; Raf Van de
Plas1; Kevin L. Schey1; Anne Solga2; David H. Gutmann2;
Richard M. Caprioli1; 1Vanderbilt University Medical Center,
Nashville, TN; 2Washington University School of Medicine,
St. Louis, MO
WP 153 Fixation of Single Sections and Whole Organs in
Formal Lithium Improves in-situ Characterisation
and Imaging of Lipids by Mass Spectrometry; Rian L.
Griffiths; Joscelyn Sarsby; Emily J. Guggenheim; Alan M.
Race; Rory T. Steven; Andrew D. Palmer; Patricia Lalor;
Josephine Bunch; University of Birmingham, Birmingham,
UK
WP 154 High Spatial Resolution Imaging of Lipids in Formalinfixed Cardiac Tissue by MALDI Imaging MS; Peggi
Angel1; Andrey Zavalin1; H. Scott Baldwin2; Richard
Caprioli1; 1Dept Biochem, Vanderbilt University, Nashville,
TN; 2Dept Cell & Dev Biol, Peds, Vanderbilt University,
Nashville, TN
WP 155 Imaging and Accurate Mass Identifications of Intact
Proteins above 10 kDa Using Multiply Charged Ions
and High Resolution MS; David G. Rizzo; Jeffrey M.
Spraggins; Kristie L. Rose; Richard M. Caprioli; Vanderbilt
University, Nashville, TN
WP 156 1,5-Diaminonaphthelene Pre-Coated Targets for MALDI
Imaging of Lipids; Junhai Yang1; Richard Caprioli1,
2 1
; Department of Biochemistry, Vanderbilt University,
Nashville, TN; 2Pharmacology and Medicine, Vanderbilt
University, Nashville, TN
WP 157 Monitoring Time-Dependent Lipid Degradation on
Tissue Sections by MALDI Imaging Mass Spectrometry;
Heath Patterson; Aurélien Thomas; Pierre Chaurand;
University of Montreal, Montreal, Canada

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Imaging MS: Software, 158 – 169

Imaging MS: Pharmaceutical Applications, 170 – 193

WP 158 MSiReader: A Free Open Source Vendor-Neutral Matlab
Interface to View and Analyze High Resolving Power MS
Imaging Data; Kenneth P. Garrard; Guillaume Robichaud;
Jeremy A. Barry; David C. Muddiman; North Carolina State
University, Raleigh, NC
WP 159 Exploration of Tensor Decomposition for Imaging Mass
Spectrometry; Yousef El Aalamat1, 4; Raf Van de Plas2; Nico
Verbeeck1, 4; Bart De Moor1, 4; Etienne Waelkens3, 4; 1KU
Leuven, ESAT-SCD/ iMinds Future Health Dept., Leuven,
BE; 2Vanderbilt University,Nashville, TN; 3KU Leuven, Dept.
Cellular and Molecular Medicine, Leuven, BE; 4KU Leuven,
Sybioma, Leuven, BE
WP 160 Customizable Open-Source Mass Spectrometry Imaging
(MSI) Data Processing Tool for Use with the .mzxml Data
File Format; Cynthia Kaeser; A. Daniel Jones; Michigan
State University, East Lansing, MI
WP 161 Mass Spectrometry Imaging Software Assisting Labeled
Normalization and Quantitation with Standardized
Open Access Format; Patrik Källback; Anna Nilsson;
Mohammadreza Shariatgorji; Per E. Andrén; Uppsala
University, Uppsala, Sweden
WP 162 Pathology Interface for Mass Spectrometry (PIMS): A
Web-Based Collaborative Tool for Histology-Directed
Mass Spectrometry Experiments; Jeremy L. Norris1; Erin
H. Seeley1; Tina Tsui1; Alireza Sepehr2; Richard M. Caprioli1;
1
Vanderbilt University School of Medicine, Nashville, TN;
2
Harvard Beth Israel Deaconess Medical Center, Boston,
MA
WP 163 Going Beyond Imaging Mass Spectrometry: Fusing
Information Across Different Imaging Technologies; Raf
Van de Plas; Junhai Yang; Richard M. Caprioli; Vanderbilt
University, Nashville, TN
WP 164 Extensible Software for the Processing of Spectrometry
Imaging Data Sped Up Using GPGPU; Alan M. Race;
Andrew D. Palmer; Rory T. Steven; Joscelyn Sarsby; Rian
L. Griffiths; Iain B. Styles; Josephine Bunch; University of
Birmingham, Birmingham, UK
WP 165 An Intelligent Data Compression Workflow for the
Analysis of Biomedical Mass Spectrometry Images;
Andrew Palmer; Rory Steven; Rian Griffiths; Alan Race;
Joscelyn Sarsby; Emily Guggenheim; Patricia Lalor;
Iain Styles; Josephine Bunch; University of Birmingham,
Birmingham, UK
WP 166 Deeper Insights through Integration: Linking Imaging
Mass Spectrometry Data with Anatomical Data; Nico
Verbeeck1, 3; Junhai Yang2; Bart De Moor1, 3; Richard
Caprioli2; Etienne Waelkens3, 4; Raf Van de Plas2; 1ESATSISTA / iMinds Future Health Dept., KU Leuven, Leuven,
Belgium; 2Vanderbilt University, Nashville, TN; 3Sybioma,
KU Leuven, Leuven, Belgium; 4Dept. of Cellular & Molecular
Medicine, KU Leuven, Leuven, Belgium
WP 167 Targeted Ion Imaging MS: Evaluation of New Algorithms
to Reduce Acquisition and Processing Time; Paul
Murray; Keith Richardson; Emmy Hoyes; Chris Jones;
Richard Chapman; Jeff Brown; Waters Corporation,
Manchester, UK
WP 168 Investigation of Different Hierarchal Clustering
Approaches for Protein Identification Directly from
Tissue Section in a MALDI Imaging Experiment; Mark
Towers1; Laura M. Cole2; Malcolm R. Clench2; Emmanuelle
Claude1; 1Waters corporation, Manchester, UK; 2Biomedical
Research Centre, Sheffield Hallam Uni, Sheffield, UK
WP 169 A New 64-Bit Software Application for MS Image
Processing; Damon Barbacci; Thomas Egan; J. Albert
Schultz; Ionwerks, Inc., Houston, TX

WP 170 Imaging Mass Spectrometry in Three-Dimensional Cell
Culture Systems for Evaluation of Therapeutics; Xin Liu;
Amanda Hummon; University of Notre Dame, Notre Dame,
IN
WP 171 Imaging Analysis of the Brain Distribution of Verapamil
by Liquid Extraction Surface Analysis (LESA) Mass
Spectrometry; Kenichi Watanabe; Jun Tadano; Toichiro
Yamada; Chihiro Ishikawa; Takao Watanabe; Tetsuya
Nakagawa; Naruaki Nomura; Masashi Yabuki; Dainippon
Sumitomo Pharma Co., Ltd., Suita, Osaka, Japan
WP 172 Potential Markers of Tumour Viability and Necrosis
in CA-4-P Treated Fibrosarcomas Employing a
Multimodal Proteomic Approach; Laura Cole1; Jo Bluff2;
Vikki Carolan1; Martyn Paley2; Gillian Tozer2; Malcolm
Clench1; 1Sheffield Hallam University, BMRC, Sheffield, UK;
2
University of Sheffield, Sheffield, UK
WP 173 Semi-Quantitative Analysis for Distribution of CNS
Drugs and Metabolites in Rat Brain by Liquid Extraction
Surfaced Analysis Mass Spectrometry; Jun Tadano;
Toichiro Yamada; Kenichi Watanabe; Tetsuya Nakagawa;
Naruaki Nomura; Masashi Yabuki; Dainippon Sumitomo
Pharma Co., Ltd., Suita, Japan
WP 174 Imaging LA-ICP-MS as a Powerful Tool for the
Investigation of Pd-tagged Photosensitizers in Tumor
Spheroids; Ann-Christin Bülter; Christoph A. Wehe;
Franziska Blaske; Olga Reifschneider; Uwe Karst;
Westfälische Wilhelms-Universtität Münster, Münster,
Germany
WP 175 Extracting More from QWBA’s with Liquid Extraction
Surface Analysis (LESA): Identifying Drug and
Metabolites Directly from Whole Rat Sections; William
Hardesty; Jill Pirhalla; Stephen Castillino; GlaxoSmithKline,
King of Prussia, PA
WP 176 Investigating the Correlation between Plasma PK
Analysis with Tissue Abundance and Distribution
by using MS Imaging and Profiling; John G. Swales1,
2
; Peter Webborn1; Malcolm Clench2; Richard Goodwin1;
1
Astrazeneca, Macclesfield, UK; 2Sheffield Hallam
University, Sheffield, UK
WP 177 Validation of Observed Metabolite to Parent Drug
Abundance Ratios from IR-MALDESI MSI by Performing
LC-MS on Adjacent Tissue Sections; Kristin M.
Klinc1; Jeremy A. Barry1; Guillaume Robichaud1; Reid
Groseclose2; David Wagner2; Stephen Castellino2; David C.
Muddiman1; 1North Carolina State University, Raleigh, NC;
2
GlaxoSmithKline, Research Triangle Park, NC
WP 178 Mapping the Distribution of Intranasally Administered
Oxytocin (OXT) in Rat Brain Using MALDI Imaging
Mass Spectrometry; Bingming Chen; Hui Ye; Mohan
Gautam; Jingxin Wang; Robert Thorne; Lingjun Li; School of
Pharmacy,University of Wisconsin, Madison, WI
WP 179 High Spatial and Mass Resolution Imaging to Assess
Ocular Drug Delivery; Cristine Quiason1; Sheerin K.
Shahidi-Latham1; Katherine A. Kellersberger2; Brian J.
Dean1; 1Genentech Inc., South San Francisco, CA; 2Bruker
Daltonics, Billerica, MA
WP 180 Imaging Mass Spectrometry of Pharmaceutical Drugs
Using a High Mass Resolution MALDI-SpiralTOF-TOF;
Ayumi Kubo1; Takaya Satoh1; Robert A. DiPasquale2; Naoki
Moriguchi3; Hisanao Hazama3; Kunio Awazu3; Michisato
Toyoda4; 1JEOL Ltd., Tokyo, Japan; 2JEOL USA, Inc.,
Peabody, MA; 3Graduate School of Engineering, Osaka
University, Osaka, Japan; 4Graduate School of Science,
Osaka University, Osaka, Japan

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WEDNESDAY POSTERS

WP 181 Mass Spectrometry Imaging of Raclopride and
Fexofenadine in Whole Body Mouse Tissue Using Laser
Ablation Electrospray Ionization Mass Spectrometry
(LAESI-MS); Callee Walsh; Pamela Williams; Gregory
Boyce; Brent Reschke; Holly Henderson; Matthew Powell;
Trust Razunguzwa; Protea Biosciences, Morgantown, WV
WP 182 Mass Spectrometric Imaging of Potential Lipid
Biomarkers in Shiverer Mice by Desorption
Electrospray Ionization for Neurologic Diseases; Daniel
Waldon; Liyu Yang; Biogen idec, Cambridge, MA
WP 183 MALDI Mass Spectrometry Imaging (MALDI-MSI) of
Pyrazinamide, Pyrazinoic Acid and Moxifloxacin in
Clinical TB Lung Biopsies; Brendan Prideaux1; Markus
Stoeckli2; Dieter Staab2; Gregory Morandi2; Clifton E Barry3;
Laura E Via3; Danielle Weiner3; Veronique Dartois1; 1Public
Health Research Institute, UMDNJ, Newark, NJ; 2Novartis
Institutes for BioMedical Research, Basel, Switzerland;
3
Tuberculosis Research Section, NIAID, Bethesda, MD
WP 184 Blood-Brain Barrier Drug Targeting by Mass
Spectrometry Imaging in Early ADME Profiling; Anna
Nilsson; Richard Goodwin; Henrik Loden; Charlotta
Wallinder; Sergio Estrada; Niklas Marklund; Mats Larhed;
Per E. Andrén; Uppsala University, Uppsala, Sweden
WP 185 Development of Combined PK/PD Studies of RAF/MEK/
mTOR Inhibitors for the Treatment of Pediatric LowGrade Astrocytomas by MALDI Mass Spectrometry
Imaging; David Calligaris1, 2; Xiaohui Liu1, 2; Daniel
Feldman1, 2; Christopher J. Thompson3; Jennifer L. Ide1, 2;
Mark Marchionni4; Sara Buhrlage4; Michael L. Easterling3;
Nathanael Gray4; Charles D. Stiles4; Nathalie Y. Agar1,
2 1
; Brigham & Women’s Hospital, Boston, MA; 2Harvard
Medical School, Boston, MA; 3Bruker Daltonics, Inc.,
Billerica, MA; 4Dana Farber Cancer Institute, Boston, MA
WP 186 MALDI-Imaging Mass Spectrometry (MALDI-IMS)
Analysis of Mouse Liver Injected with Gold and Copper
Nanoparticles; Dionysios Pantazatos1, 2; Irene (Eirini)
Panderi (Panteri) 1, 4; Liangran Guo3; Wei Lu3; 1COBRE
Center for Cancer Research and Development, Providence,
RI; 2Warren Alpert Medical School, Brown University,
Providence, RI; 3University of Rhode Island, College or
Pharmacy, Kingston, RI; 4University of Athens, Pharmacy,
Pharm.Chemistry, Athens, Greece
WP 187 Developing Imaging Mass Spectrometry in 3D Cell
Cultures; Amanda B. Hummon; Eric Weaver; Xin Liu;
Haohang Li; Dorothy Ahlf; University of Notre Dame, Notre
Dame, IN
WP 188 MALDI-MS Imaging of LCL124 (SPG103) Tissue
Distribution and Molecular Effects on Lipids and
Glycans in a Prostate Tumor Xenograft Model; Ellen
Jones; Xiang Liu; James Norris; Richard Drake; Medical
University of South Carolina, Charleston, SC
WP 189 Pharmaco-Imaging Analysis of Anti-cancer Agents
in Tumor Tissues Using Mass Microscope; Shuichi
Shimma; Yuki Takashima; Akinobu Hamada; National
Cancer Center Research Institute, Tokyo, Japan
WP 190 Cosmetic Analysis Using MALDI-MSI – “Cosmetomics”;
Diogo De Oliveira; Sabrina de Bona Sartor; Mônica
Ferreira Siqueira; Rodrigo Ramos Catharino; INNOVARE
Biomarkers Lab, University of Campinas, Campinas, Brasil
WP 191 A nano-PALDI Protocol for Anticancer Drugs Tumor
Uptake and Distribution Studies; Enrico Davoli; Lavinia
Morosi; Pietro Spinelli; Maria G. Carrera; Raffaella Giavazzi;
Massimo Zucchetti; Maurizio D’Incalci; Mario Negri Institute,
Milano, Italy
WP 192 MALDI-MS Imaging of the Molecular Profile Changes
Resulting from Sphingosine Kinase Inhibition in an
Orthotopic Pancreatic Cancer Model; Peng Gao; E. Ellen

Jones; Thomas Powers; Stephen Roper; Benjamin Neely;
Drew Schoenling; Charles Smith; Richard R Drake; Medical
University of South Carolina, Charleston, SC
WP 193 Use of High Resolution MSI Combined with
Metabolomics Study to Evaluate Drug Efficacy and
Impact onto Biological Environment; David Bonnel1;
Gregory Hamm1; Guillaume Hochart1; Fred Fack2; Olivier
Keunen2; Fabien Pamelard1; Raphael Legouffe1; Simone
Niclou2; Jonathan Stauber1; 1ImaBiotech, MS Imaging
Department, Lille, France; 2CRP Santé, Luxembourg
Imaging MS: Small Molecules, 194 – 221
WP 194 Imaging of Molecular Distribution in Areca Nut by
Desorption Electrospray Ionization Mass Spectrometry
(DESI-MS); Amitava Srimany; R. G. Hemalatha; Danica
Glenda Pinto; Hemanta R. Naik; T. Pradeep; IIT Madras,
Chennai, India
WP 195 Small Molecules Detection with an Ultrashort Pulsed
Laser Ablation VUV Postionization TOF-MS; Yang Cui;
Chhavi Bhardwaj; Slobodan Milasinovic; Robert Gordon;
Luke Hanley; Univ. of Illinois at Chicago, Chicago, IL
WP 196 Laser Ablation Atmospheric Pressure Photoionization
Mass Spectrometry Imaging of Sage Leafs; Anu
Vaikkinen1; Bindesh Shrestha2; Risto Kostiainen1; Akos
Vertes2; Tiina J. Kauppila1; 1University of Helsinki, Helsinki,
Finland; 2George Washington University, Washington, DC
WP 197 Whole-Body DESI Imaging of Clozapine and Its
Metabolite; Jingzhou Liu; Zhiyang Zhao; Yohannes Teffera;
Amgen, Cambridge, MA
WP 198 Direct Coupling of TLC with MALDI-TOF Mass
Spectrometry for Analysis of Extracted Phospholipids
from DMXAA Treated Xenograft Tumor; Afnan Batubara1;
Malcolm Clench1; Paul Loadman2; Chris Sutton2; 1Sheffield
Hallam University, Sheffield, UK; 2University of bradford,
Bradford, UK
WP 199 MALDI Tissue Imaging: Identification of Amino Acid and
Neurotransmitter Metabolites; M. Lisa Manier; Jeffrey M.
Spraggins; Michelle L. Reyzer; Jeremy L. Norris; Richard M.
Caprioli; Vanderbilt University, Nashville, TN
WP 200 MALDI Imaging of Metabolites During the Germination
of a Corn Seed; Adam Feenstra1, 2; Andrew Korte1, 2;
Young Jin Lee1, 2; 1Iowa State University, Ames, IA; 2Ames
Laboratory/USDOE, Ames, IA
WP 201 MALDI Imaging of Forensic Samples by Using a
Spiral-Trajectory Ion Optics Time-of-Flight Mass
Spectrometer; Masaaki Ubukata; John Dane; Robert B.
Cody; Donna Guarrera; Masateru Shibata; JEOL USA, Inc.,
Peabody, MA
WP 202 Localization of Endogenous Metabolites in Diabetic
Mouse Brain Tissue Using MALDI Imaging Mass
Spectrometry; Michelle L. Reyzer1; Andre Kleinridders2;
Heather Ferris2; Jeffrey M. Spraggins1; C. Ronald Kahn2;
Richard M. Caprioli1; 1Vanderbilt University, Nashville, TN;
2
Joslin Diabetes Center, Harvard University, Boston, MA
WP 203 MALDI-IMS-MSI Examinaton of Emollient Treated Living
Skin Equivalent for Lipidomic and Small Molecule
Analysis; Christopher Mitchell; BMRC, Sheffield, UK
WP 204 Rat Skeletal Muscle Fiber Differentiation Using Mass
Spectrometric Imaging (MSI) and Tandem MS (MSn);
Yu-Hsuan Tsai1; Timothy Garrett2; Christy Carter3; Richard
Yost1; 1Department of Chemistry, University of Florida,
Gainesville, Fl; 2Department of Pathology, University of
Florida, Gainesville, Fl; 3Dept. Aging & Geriatric Research,
Univ of Florida, Gainesville, FL

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WP 205 Nanoparticle Assisted Laser Desorption Ionization
Mass Spectrometry for Chemical Imaging of Plant
Metabolites; Gargey Yagnik1, 2; Andrew Korte1, 2; YoungJin Lee1, 2; 1Iowa State University, Ames, IA; 2Ames lab US
DOE, Ames, IA
WP 206 Promethazine as a PET Probe for Amyloid Beta in
Alzheimer’s Disease Using MALDI Imaging Mass
Spectrometry; Chad Chumbley; Richard McClure; Michelle
Reyzer; Wellington Pham; Richard Caprioli; Vanderbilt
University, Nashville, TN
WP 207 Mass Spectrometry Imaging of Leaf Surface Using
Platinum Vapor Deposition Assisted Laser Desorption/
Ionization; Tomoyuki Ozawa; Hideya Kawasaki; Ryuichi
Arakawa; Kansai University, Osaka, Japan
WP 208 Spatial Correlation Combined with Hierarchal
Clustering Analysis for Reducing Complex MultiDimensional MALDI Imaging Dataset; Hernando Olivos1,
2
; Kieran Neeson1, 2; Emmanuelle Claude1, 2; Mark Towers1, 2;
1
Waters Corporation, Manchester, UK; 2Waters Corporation,
Beverly, MA
WP 209 Investigations into Adjuvant Efficacy upon the Surface
Distribution and Penetration of a Herbicide into Plant
Leaves by LAESI-MS Imaging; Stephen Rumbelow1;
Gregory Lindner1; Holly Henderson2; Alicia Morgan2;
Haddon Goodman2; 1Croda Inc, New Castle, DE; 2Protea
Biosciences Group Inc., Morgantown, WV
WP 210 MALDI-MS Imaging and Quantitation of Acetylcholine
in Mouse Brain after Administration of Cholinesterase
Inhibitor Using Deuterated CHCA as Matrix;
Mohammadreza Shariatgorji1; Nicoletta Schintu2; Per
Svenningsson2; Per. E Andrén1; 1Uppsala University,
Uppsala, Sweden; 2Karolinska Institute, Stockholm, Sweden
WP 211 Imprinting and MALDI-MS Imaging of Metabolites
from Soybean Leaves; Adam Klein1, 2; Gargey Yagnik1, 2;
Young-Jin Lee1, 2; 1Iowa State University, Ames, IA; 2Ames
Laboratory US-DOE, Ames, IA
WP 212 In situ Quantitative Protein-Metal Co-Localization
Using Imaging by Laser Ablation-Inductively Coupled
Plasma-Mass Spectrometry; Dominic Hare1, 2; Peng Lei2;
Scott Ayton2; Rudolf Grimm3; Jessica George2; Robert
Cherny2; Paul Adlard2; Ashley Bush2; David Finkelstein2;
Philip Doble1; 1University of Technology, Sydney, Broadway,
Australia; 2Florey Institute of Neuroscience and Mental
Health, Melbourne, Australia; 3Agilent Technologies, Santa
Clara, CA
WP 213 Carbon Nanodots as a Novel Matrix for the Analysis
of Small Molecules by MALDI-TOF MS; Chen Suming;
Nie Zongxiu; Institute of Chemistry Chinese Academy of
Sciences, Beijing, China
WP 214 Visualizing Metabolites in Plants and Insects with High
Resolution AP-SMALDI MS Imaging; Dhaka Bhandari;
Andreas Roempp; Bernhard Spengler; Justus Leibig
University Giessen, Giessen, Germany
WP 215 Distribution and Identification of Molecular Interactions
between Tomato Roots and Bacterial Biofilms; Delphine
Debois 1; Emmanuel Jourdan2; Nicolas Smargiasso1; Marc
Ongena3; Edwin De Pauw1; 1University of Liege, Liège,
Belgium; 2University of Liege - CWBI, Liege, Belgium;
3
University of Liege Gembloux Agro-Bio Tech, Gembloux,
Belgium
WP 216 Imaging of Lipids in Rat Sciatic Nerve; Roberto
Fernandez1; Javier Diez-Garcia2; Miguel Alaminos3; Begoña
Castro Feo2; Alejandro Garcia-Garcia2; Jose A. Fernandez1;
1
Universidad del Pais Vasco, Leioa, Spain; 2Histocell S. L.,
Derio, Sp; 3University of Granada, Granada, Spain

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WP 217 Imaging Mass Spectrometry: Insights into the
Interactive Metabolome of Pseudomonas aeruginosa;
Vanessa Phelan1; Wilna Moree1; Alexandra Koumoutsi2;
Suzanne Noble2; Pieter Dorrestein1; 1UC, San Diego, La
Jolla, CA; 2University of California, San Francisco, CA
WP 218 MALDI Imaging MS of Metabolites in Human Cancer
Tissues; Tim Dekker; Emrys Jones; René van Zeijl; Willem
Corver; Rob Tollenaar; André Deelder; Hans Morreau;
Wilma Mesker; Liam Mcdonnell; Leiden University Medical
Center, Leiden, Netherlands
WP 219 Identifying the Neuroanatomical Substrate Involved
in ICVNPY Inhibition of Reinstatement of CocaineInduced Behavior in Rats by MALDI Imaging; Leila
Hosseinzadehshahri; Buffalo, NY
WP 220 Complimentary Use of MALDI FTICR-MS and TOFSIMS Imaging Approaches in an Invertebrate; Manuel
Liebeke1; Jens Fuchser2; Katherine A. Kellersberger3; Sarah
Fearn4; David McPhail4; Jacob G. Bundy1; 1Department of
Surgery and Cancer, Imperial College, London, UK; 2Bruker
Daltonik, Gmbh, Bremen, DE; 3Bruker Daltonics, Inc.,
Billerica, MA; 4Department of Materials, Imperial College,
London, UK
WP 221 Structural Properties of Metabolites that Dominate the
Ionization Efficiency in MALDI with 9-Aminoacridine
as the Matrix; Daichi Yukihira; Daisuke Miura; Yoshinori
Fujimura; Mitsuru Shindo; Hiroyuki Wariishi; Kyushu
University, Fukuoka, Japan
Informatics: Small Molecule Identification
and Characterization, 222 – 233
WP 222 LC-LC-MS/MS Heart-Cut Approach for Software
Assisted Pharmaceutical Impurity Identification from
Non-MS Compatible LC Method Using Time of Flight
Mass Spectrometer; Siji Joseph; Ravindra Gudihal;
Suresh Babu C.V; Agilent Technologies, Bangalore, India
WP 223 Scoring Methods for Interpreting Mass Spectra of
Unknown Structures Using the MASSPEC Algorithm;
Marshall M. Siegel 1; Gary Walker1; Yongdong Wang2; 1MS
Mass Spec Consultants, Fair Lawn, NJ; 2Cerno Bioscience,
Norwalk, CT
WP 224 Fragmentation Outcome Modelling: Prototype Software
for Prediction of CID Fragment Ions for Small Molecule
Structures; Kirsten Hobby 1; Richard Gallagher2; Neil
Loftus1; 1Shimadzu MS/BU, Manchester, UK; 2AstraZeneca,
Macclesfield, UK
WP 225 Automated Tool for Substructure Annotation of
Accurate Mass MS/MS Spectra; Yan Ma; Tobias Kind;
Oliver Fiehn; University of California,Davis, CA
WP 226 Method for Assessing the Statistical Significance of
Mass Spectral Similarities by Using BLAST Statistics;
Fumio Matsuda; Hiroshi Tsugawa; Eiichiro Fukusaki; Osaka
Univeristy, Suita, Japan
WP 227 Accurate Mass Report Generation with Spectral
Accuracy Isotope Scoring within a High Throughput
Laboratory; Christopher Williams1; Yongdong Wang2; Leo
Xu2; Ming Gu2; 1Swansea University, Swansea, UK; 2Cerno
Bioscience, Norwalk, CT
WP 228 Increasing LC/MS Workflow Capacity with Data
Analysis by Exception Strategies; Timothy Dunne; Chan
C. K; Travis Mathewson; Holly Mckeith; Rosalia Gonzales;
Pfizer, Groton, CT
WP 229 Critical Assessment of Small Molecule Identification:
Results of the Inaugural CASMI Contest 2012; Emma
Schymanski; Steffen Neumann2; 1Eawag: Swiss Federal
Institute of Aquatic Science, Dübendorf, Switzerland; 2Leibniz
Institute of Plant Biochemistry, Halle (Saale), Germany

61ST ASMS CONFERENCE ON MASS SPECTROMETRY

WEDNESDAY POSTERS

WP 230 Towards a Workflow for the Automated Structural
Elucidation of Unknowns from MS/MS Spectra; Gerard
Hopfgartner1; Abhinandan KR1; Emmanuel Varesio1; Eva
Duchoslav2; Lyle Burton2; Ron Bonner2; 1University of Geneva,
Geneva, Switzerland; 2AB Sciex, Concord, ON, Canada
WP 231 Identification of Unknown Metabolites Using Tandem
MS: Improving the Quality of Fragmentation Trees; Kai
Dührkop; Kerstin Scheubert; Sebastian Böcker; FriedrichSchiller University Jena, Jena, Germany
WP 232 Integrating Datasets from Drug Metabolism and
Bioanalytical Studies and Fixing the Missing Link
for Quan/Qual; Mark D. Wrona; Craig Dorschel; Yun
W. Alelyunas; Kevin Cook; Stephen McDonald; Paul D.
Rainville; Waters Corporation, Milford, MA
WP 233 Characterization of Oxidative Forced Degradation
Products Using Fragment Ion Search; Chunang
(Christine) Gu 1; Jane Li1; Kate Comstock2; Alan Deese1;
1
Genentech, South San Francisco, CA; 2Thermo Fisher
Scientific, San Jose, CA
Small Molecules: Qualitative Analysis, 234 – 251
WP 234 Characteristic Retro-Diels-Alder Fragmentation of
Four Cephalosporins and Their Δ-3 Isomers in Positive
and Negative Mode: An Experimental and Theoretical
Study; Jian-Qin Qian1, 2; Chang-Qin Hu1; 1National Institutes
for Food and Drug Control, Beijing, China; 2Peking Union
Medical College, Beijing, China
WP 235 Fundamental Study of Mechanisms of CollisionActivated Dissociation of Ionized Asphaltenes’ Model
Compounds Using a Linear Quadrupole Ion Trap Mass
Spectrometer; James Riedeman; Nadine Njoya; David
Borton; Matt Hurt; Hilkka Kenttämaa; Purdue University,
West Lafayette, IN
WP 236 Structural Elucidation of Small Drug Molecules Using
Q-TOF, LTQ-Orbitrap and GC-EI-MS with Supersonic
Molecular Beams (SMB); Lena von Sydow1; Anja Ekdahl1;
Carina Leandersson1; Marie Tysk-Rönnqvist2; Aviv Amirav3;
1
AstraZeneca R&D, Mölndal, Sweden; 2AstraZeneca
Operations, Södertälje, Sweden; 3Tel Aviv University, Tel
Aviv, Israel
WP 237 Novel Glutathione Conjugates of Phenyl Isocyanate
Studied by Ultra-Performance Liquid Chromatography/
Electrospray Ionization Mass Spectrometry; Tove
Johansson Mali’n; Crister Åstot; Swedish Defense
Research Agency, Umeå, Sweden
WP 238 Mass Spectrometric Detection of Local Anesthetics
Masking Prohibited Practice of Inducing Limb Soring
in Walking Horses to Enhance Appeal; Szabolcs Szarka;
Laszlo Prokai; UNT Health Science Center, Fort Worth, TX
WP 239 Investigation of an Impurity in Carboplatin through a
Forced Degradation Study; Jeffrey Selenka1; Cynthia
Sanderson2; 1PPD Inc., Madison, WI; 2AB SCIEX,
Framingham, MA
WP 240 Unusual Degradation Products of Selective β-Amyloid
Aggregation Inhibitor BTB01473; Ludmila Alexandrova1;
Paul A. Novick2; Vijay S. Pande2; Allis Chien1; 1Stanford
University Mass Spectrometry, Stanford, CA; 2Stanford
University, Chemistry Department, Stanford, CA
WP 241 On-line Nanopore Optical Interferometry-Mass
Spectrometry for Screening and Quantifying Small
Molecule-Protein Interactions; Iain D G Campuzano; Paul
D Schnier; Klaus Michelsen; Amgen Inc., Thousand Oaks, CA
WP 242 Fast Analysis of Stereo and Structural Related Isomers
using Supercritical Fluid Chromatography-Mass
Spectrometry; Yuqin Dai; Lisa Zang; Agilent Technologies,
Santa Clara, CA

WP 243 Principal Component Analysis of Laser Desorption
Postionization Mass Spectrometry Data for Mixed/
Coculture Biofilms; Chhavi Bhardwaj1; Yang Cui1;
Theresa Hofstetter2; Suet Liu2; Hans C. Bernstein3; Ross
P. Carlson3; Musahid Ahmed2; Luke Hanley1; 1University
of Illinois at Chicago, Chicago, IL; 2Lawrence Berkeley
National Laboratory, Berkeley, CA; 3Montana State
University, Bozeman, MT
WP 244 New Methodology for the Analysis of Highly
Hydrophobic Calixarenes by MALDI-TOF Mass
Spectrometry; Vincent Guérineau1; Vincent Huc2; David
Touboul1; Baptiste Boutonnet2; Cyril Martini2; Alain Brunelle1;
1
CNRS, Institut de Chimie des Substances Naturelles, Gif-surYvette, France; 2Université Paris-Sud, ICMMO, Orsay, France
WP 245 Creation of Uniquely Deep and Rich Datasets for the
Structural Elucidation of Metabolites in Quan/Qual
Analyses; Jonathan L. Josephs 1; Timothy Stratton2;
William Humphreys1; 1Bristol-Myers Squibb, Pennington,
NJ; 2Thermo Scientific, San Jose, CA
WP 246 Application of Mass Spectrometry to Support
Authentication and Characterization of Counterfeit
Pharmaceuticals; Michael Peddicord; Charles Pathirana;
Holly Shackman; Mark Bolgar; Scott Miller; Bristol-Myers
Squibb, New Brunswick, NJ
WP 247 Application of MALDI-Mass Spectrometry to
Investigation of Active Layer Degradation in Organic
Solar Cells; Evgenia Akhmetova; Matthew McMahon;
Santhosh Narasimhachary; Charles L. Wilkins; University of
Arkansas, Fayetteville, AR
WP 248 LCMSMS Technique Reveals the Structure of New
Impurity in Valproic Acid, an Anticonvulsant Drug –
Unseen in GC Analysis!; Arugavur Ponnusamy Kannan1;
D. Easwaramoorthy1; Raman Palvannanathan2; Mohan
Kasi2; Saravanan Subramaniyan2; Janani Thyagarajan2;
Venkat Manohar2; 1Dept. of Chemistry B.S.Abdur Rahman
University, Chennai, India; 2IICMS, Chennai, India
WP 249 Understanding the role of Solvent Media towards
Peroxide Degradation Products of Lenalidomide, an
Anticancer Compound Using LCMSMS Technique;
Janani Thyagarajan1; Raman Palvannanathan1; Mohan
Kasi1; Govindarajan Chandramohan1; Saravanan
Subramaniyan1; Thaminum Ansari Abubacker2; Venkat
Manohar1; 1IICMS, Chennai, India; 2Muthurangam Govt.
Arts College, Vellore, Tamil Nadu, India
WP 250 Characterization of Hitherto Unknown Process
Related Impurities of Crizotinib through Multiple
Collision LCMSMS Analysis; Saravanan Subramaniyan1;
Thaminum Ansari Abubacker2; Mohan Kasi1; Govindarajan
Chandramohan1; Rampriya Uthayakumar1; Raman
Palvannanathan1; Arvind Thyagarajan1; Venkat Manohar1;
1
IICMS, Chennai, India; 2Muthurangam Govt. Arts College,
Vellore, Tamil Nadu, India
WP 251 Identification of an Unknown Photo-degradant in Active
Pharmaceutical Ingredient; Meng Xu; Hongfei Yue; John
Castoro; Bristol-Myers Squibb, New Brunswick, NJ
Drug Metabolism: Qualitative Analysis, 252 – 282
WP 252 Identification of Tamoxifen Metabolites in Human Serum
using the iHumite Workflow: Metabolite Prediction, LCHRMS and MS Vendor Independent Data Processing;
Peter L. Jacobs1, 2; Lars Ridder3; Marco Ruijken4; Hilde
Rosing5; Nynke G.L. Jager5; Jos H. Beijnen5; Richard R.
Bas1; William D. van Dongen1; 1TNO Triskelion, Zeist, The
Netherlands; 2MSam, Oss, The Netherlands; 3Wageningen
University, Wageningen, The Netherlands; 4MsMetrix,
Maarssen, The Netherlands; 5Slotervaart Hospital,
Netherlands Cancer Institute, Amsterdam, The Netherlands

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WEDNESDAY
POSTERS

WP 253 IPeaks: Isotope Pattern Matching for Fast and Sensitive
Drug Metabolite Detection using High Resolution Mass
Spectrometry; Marco Ruijken; MsMetrix, Maarssen,
Netherlands
WP 254 Evaluation of Xevo G2-S Q-ToF and UNIFI Software
for the Identification and Relative Quantitation of
Metabolites; Richard Clayton1; Richard Lock2; Lucy
Fernandes2; 1Covance, Harrogate, UK; 2Waters Ltd,
Manchester, UK
WP 255 Comparison of MS/MSall with SWATH™ and Information
Dependent Acquisition Methods for Increased
Throughput in Metabolic Soft-Spot Identification Using
HRMS; Veronica Zelesky1; Richard Schneider1; John
Janiszewski1; Yves LeBlanc2; Eva Duchoslav2; 1Pfizer Inc.,
Groton, CT; 2AB SCIEX, Concord, Canada
WP 256 Automated Metabolite Identification and Profiling in
Non-Specific Fragmentation High Resolution Accurate
Mass Spectrometry Data; Eva Duchoslav; Gordana
Ivosev; Ignat Shilov; Hesham Ghobarah; Lyle Burton; AB
SCIEX, Concord, Canada
WP 257 Increasing the Number of Identified Metabolites from
in-vitro and in-vivo Samples with All Ion Fragmentation
on an Orbitrap Mass Spectrometer; Joseph T. Marini; Jie
Ding; Donald L. McKenzie; Covance, Madison, WI
WP 258 Multiple Fragmentation Techniques for Comprehensive
Metabolite Identification; Jack Cunniff1; Kelly Wang2; Gene
Eiserberg2; Tim Stratton1; Kate Comstock1; 1Thermofisher
Scientific, San Jose, CA; 2Gilead Sciences, Inc., Foster City,
ca
WP 259 Using HRAM Survey Analysis Combined with Rapid
MS2 Data to Develop a Fragmentation Based Detection
Workflow for Structure ID Acquisition; Tim Stratton;
Thermo Fisher Scientific, San Jose, CA
WP 260 Electrochemically Initiated Reactions Upfront MS - EC/
MS an Unknown Panacea? Martin Eysberg; Agnieszka
Kraj; Hendrik-Jan Brouwer; Nico Reinhoud; Jean-Pierre
Chervet; Antec, Zoeterwoude, The Netherlands
WP 261 In vitro Mimicry of Metabolism of Xanthohumol by
Electrochemistry Combined with LC-DAD-MS/MS;
Andries P. Bruins1; Jan F. Stevens2; Ulrik Jurva3; 1University
of Groningen, Groningen, Netherlands; 2Oregon State
University, Corvallis, OR; 3AstraZeneca, Mölndal, Sweden
WP 262 Use of On-Line Electrochemistry/High-Resolution
Mass Spectrometry for the Estimation of the Site of
Glucuronidation; Kazuyoshi Nozaki1; Kenji Tabata1; Toshio
Teramura1; Mitsuo Takayama2; 1Astellas Pharma Inc.,
Tsukuba, Japan; 2Yokohama City University, Yokohama,
Japan
WP 263 Automation Strategies for an Electrochemistry/MS
Method for Metabolism Studies; Hannah Simon; Michael
Kießhauer; Uwe Karst; University of Münster, Münster,
Germany
WP 264 Utility of Data-Independent LC/MSE with Ion Mobility
to Increase Coverage of Nefazodone Metabolites from
in-vivo Matrices; Joseph T. Marini1; Andrew G. Baker2;
Jie Ding1; Donald L. McKenzie1; 1Covance, Madison, WI;
2
Waters Corporation, Pleasanton, CA
WP 265 Evaluation of Differential Mobility Techniques for
Quantitative and Qualitative Identification Workflows
in Pharmaceutical Environments; Keith Goodman; Paul
Clemens; James Ferguson; Loren Olson; AB SCIEX, San
Jose, CA
WP 266 Analysis of Urine Samples using Microflow LC Coupled
to Differential Ion Mobility Spectrometry; Carmai Seto;
Pauline Vollmerhaus; Alina Dindyal-Popescu; Deolinda
Fernandes; Takeo Sakuma; AB SCIEX, Concord, Canada

PAGE 130					

WP 267 A Novel Method for the Determination of the Site of
Glucuronidation by Ion Mobility Spectrometry-Mass
Spectrometry; Atsushi Shimizu; Taiho Pharmaceutical,
Tsukuba City, Japan
WP 268 Identification of Human Drug Metabolites with Poor
Mass Spectrometric Response Using LC-MS Assisted
by TopCount Radioactive Detection; Manfred Zell;
Christophe Husser; F. Hoffmann-La Roche Ltd, Basel,
Switzerland
WP 269 Investigation of Metabolism of Peptide Drug by
127
I-tagging Follow by Analyses Using Capillary UPLC
Coupled to ICP-MS and ESI-LTQ/Orbitrap; Heng-Keang
Lim; Janssen Pharmaceuticals R&D, Raritan, NJ
WP 270 Molecular Level Probing of the Mechanism and
Biological Activity of Metal-based Anticancer Drug
Candidates by ESI FT-ICR Mass Spectrometry; Zhihua
Yang; Dajena Tomco; Claudio N. Verani; Mary T. Rodgers;
Wayne State University, Detroit, MI
WP 271 Characterization of Bromopride and Metoclopramide
N-O-glucuronides in Human Hepatocytes by HPLC/ESI/
FTMS/MS and Hydrogen Deuterium Exchange; Jennifer
L. Bushee1; Christine E. Dunne2; Kevin Colizza1; Amanda
Cirello1; Upendra A. Argikar1; 1Novartis, Cambridge, MA;
2
Northeastern University, Boston, MA
WP 272 Mass Spectrometric Study of the Nitration and
Halogenation of the ß2-Agonist Albuterol; Larry Sallans
1
; Stephen Macha1; Kari Brown1; Dennis McGraw1, 2; Melinda
Butsch Kovacic1, 3; Sara Stigler1, 3; Bradley Britigan4, 5;
1
University of Cincinnati, Cincinnati, OH; 2Veterans Affairs
Medical Center, Cincinnati, OH; 3Cincinnati Children’s
Hospital, Cincinnati, OH; 4University of Nebraska Medical
Center, Omaha, NE; 5Veterans Affairs Medical Center - NE/
Western IA, Omaha, NE
WP 273 Investigations of Sulfation Phenotyping and Kinetics
of Raloxifene and the Active Metabolites of Tamoxifen;
Lori Coward1; Greg Gorman1; Teresa Wilborn2; Gwen
Nance2; 1Pharmaceutical Sciences Research Institute,
Samford University, Birmingham, AL; 2McWhorter School of
Pharmacy, Samford University, Birmingham, AL
WP 274 Turning Drug Glucosides into Glucuronides – Making
Fungal Incubations Work Together with Chemical
Derivatization; Axel Rydevik1; Ulf Bondesson1, 2; Mario
Thevis3; Mikael Hedeland1, 2; 1Uppsala University, Uppsala,
Sweden; 2National Veterinary Institute (SVA), Uppsala,
Sweden; 3German Sport University, Cologne, Germany
WP 275 Unusual Phase I and Phase II Metabolites Prepared
by Biotransformation and Their Unexpected MS/MS
Fragmentation; Andreas Fredenhagen; Juergen Kuehnoel;
Matthias Kittelmann; Kirsten Schroer; Stephan Luetz; Reiner
Aichholz; Lukas Oberer; Novartis Institutes for BioMedical
Research, Basel, Switzerland
WP 276 Evaluation of the Fungus Cunninghamella elegans as a
Model for the Formation of Reactive Metabolites Using
Glutathione Trapping and UHPLC/HRMS; Axel Rydevik2;
Anna Hellqvist2; Ulf Bondesson1; Mikael Hedeland1; 1Nat’l
Veterinary Institute, Uppsala, Sweden; 2Uppsala University,
Uppsala, Sweden
WP 277 UHPLC-MS-MS with Fast Precursor Ion and Neutral
Loss Scanning and Glutathione Trapping for Detecting
Reactive Metabolites of Licorice; Ke Huang; Richard B.
van Breemen; University of Illinois College of Pharmacy,
Chicago, IL
WP 278 A Reactive Metabolite Investigation of Fenclozic
Acid by LC-UV-MSMS; Scott Martin1; Malcolm clench2;
1
Astrazeneca, Macclesfield, UK; 2Sheffield Hallam university,
Sheffield, UK

61ST ASMS CONFERENCE ON MASS SPECTROMETRY

WEDNESDAY POSTERS

WP 279 Proteomic Characterization of Ocular S9 Fractions
for Biotransformation Studies in Ophthalmic Drug
Discovery; Joshua L. Johnson; Jennifer L. Bushee;
Upendra A. Argikar; Amin Kamel; Shawn Harriman; NIBR,
Cambridge, MA
WP 280 A Comparison of LC-MS and a Prototype MicrofluidicsMS Device in the Metabolite Identification of in-vitro
and in-vivo Samples; Philip Tiller1; Mark D. Wrona2;
Yun W. Alelyunas2; Catalin Doneanu2; Paul D. Rainville2;
1
RMI Laboratories, North Wales, PA; 2Waters Corporation,
Milford, MA
WP 281 Characterization of Long Lasting Plasma Radioactivity
in Monkey following Single Oral Dose of C-14 labeled
Merck Compound A; Yuexia Liang; Sheri Smith; Kelem
Kassahun; Thomayant Prueksaritanont; Dan Cui; PPDM,
Merck, West Point, PA
WP 282 LC-MSn Analysis of Metabolites of ST-255, a Novel AntiLassa Virus Compound; X. Steven Yan; Brian Furmanski;
Daniela Kropf; Dongcheng Dai; Jim Burgeson; Candace
Lovejoy; Sean Amberg; Shanthakumar Tyavanagimatt;
Janet Leeds; SIGA Technologies, Inc., Corvallis, OR
Drug and Metabolite Analysis: Novel Approaches for
Dried Biological Samples, 283 – 291
WP 283 Determination of Opiates and Opioids in Dried Blood
Spots Using Novel Flow-Through Technology Coupled
to LC/MS/MS; Dennis Nagtalon1; Kevin McCann1; Na Pi
Parra 1; Ken Lewis2; 1Agilent Technologies, Santa Clara,
CA; 2OpAns, Durham, NC
WP 284 Rapid Online LC-TOF-MS Analysis of Glycated
Hemoglobin from dried Blood Spots Using Automated
Direct Flow-Through Elution; Robert J. Seward1; Dhvani
Shah1; Jonathan Wilson1; Catherine Stacey1; Christel
Hempen2; 1PerkinElmer, Waltham, MA; 2Spark Holland,
Emmen, The Netherlands
WP 285 Advancing Quantitative Dried Blood Spot Analysis
Using Temperature-Enhanced Flow-Through Desorption
Coupled Online to Solid‑Phase Extraction and Mass
Spectrometry; Christel Hempen; Lena Knegt; Bert Ooms;
Spark Holland B.V., Emmen, Netherlands
WP 286 Application of Micro Fluidic LC/MS/MS for the
Quantification Rosuvastatin from Dried Blood Spots:
A Clinical Study Example; Robert Plumb2; Nicola Gray1;
Ian Wilson2; Paul Rainville1; 1Waters, Milford, MA; 2Imperial
College, London, UK
WP 287 Direct Automated Analysis of Dried Blood Spots (DBS)
by 2D LC-HRMS: Effects of Hematocrit on DBS Results;
Regina Oliveira1; Jack Henion1; Enaksha Wickremsinhe2;
1
Advion Bioanalytical Labs, a Quintiles Company, Ithaca,
NY; 2Drug Disposition, Eli Lilly and Company, Indianapolis,
IN
WP 288 Development of a Molecular Filtration Membrane
Substrate as an Alternative for DBS LC/MS
Bioanalyses; Robert Sturm1; Jack Henion1; Richard
Abbott2; Phillip Wang3; 1Advion Bioanalytical Labs, a
Quintiles company, Ithaca, NY; 2Shire Pharmaceuticals,
Basingstoke, UK; 3Shire Development, Wayne, PA
WP 289 Comparison of Proteins in Liquid and Dried Blood
Spot Samples by HPLC/ESI-MS/MS; Andrew Chambers1;
Andrew Percy1; Darryl Hardie1; Christoph Borchers1, 2;
1
University of Victoria-Genome BC Proteomics Centre,
Victoria, Canada; 2Dept of Biochemistry and Microbiology, U
Victoria, Victoria, Canada
WP 290 Heat Stabilized Blood Spots as Alternative to Standard
DBS Sampling – Analyte Stability and Coextraction
of Matrix Proteins; Karl Skold1; David Zeeberg1; Daniel
Blessborn2; Karnrawee Kaewkhao2; Olof Sköld1; Martin

Ahnoff3; 1Denator AB, Uppsala, Sweden; 2Mahidol
University, Bangkok, Thailand; 3University of Gothenburg,
Gothenburg, Sweden
WP 291 Determination of Eight Metabolically Unstable Drugs
in Blood by Heat-Stabilized DBS and LC-MS/MS; Olof
Skold1; Karl Sköld1; David Zeeberg1; Gunnar Hägglund4;
Eskil Hermansson4; Peter Abrahamsson2; Martin Ahnoff3;
1
Denator AB, Gothenburg, Sweden; 2Agilent Technologies,
Gothenburg, Sweden; 3University of Gothenburg,
Gothenburg, Sweden; 4Q&Q labs AB, Gothenburg, Sweden
Metabolomics: Quantitative Analysis, 292 – 311
WP 292 Targeted Ion Mobility and Liquid Chromatography-Mass
Spectrometry Metabolomic Strategies for Glucose
Quantitation in Exhaled Breath Condensate for Cystic
Fibrosis Studies; María Monge1; Jose Perez1; Prabha
Dwivedi1; Manshui Zhou1; Arlene Stecenko2; Facundo
Fernández1; 1Georgia Institute of Technology, Atlanta, GA;
2
Emory University School of Medicine, Atlanta, GA
WP 293 Quantitative Analysis of Small Molecule
Neurotransmitters Secreted by hESCs Derived
Serotonergic Neurons via Capillary ElectrophoresisElectrospray Ionization-Multiple Reaction Monitoring;
Xuefei Zhong; Hui Ye; Jianfeng Lu; Su-chun Zhang; Lingjun
Li; University of Wisconsin, Madison, WI
WP 294 Quantification of AQC Derivatized Polyamines in
Bovine Intraluminal Fluids by UPLC-MS/MS after Solid
Phase Extraction; Maxim Maheux; Claude-Paul Lafrance;
TransBIOTech, Levis, Canada
WP 295 The Potential of Two Dimensional Liquid
Chromatography in Mass Spectrometric Assays of
the Primary Metabolome; Kristaps Klavins1, 2; Dinh
Binh Chu1; Stefan Neubauer1; Stephan Hann1, 2; Gunda
Koellensperger1, 2; 1BOKU - Vienna, Vienna, Austria;
2
Austrian Centre of Industrial Biotechnology (ACIB), Vienna,
Austria
WP 296 Simultaneous Analysis of Hydrophilic Metabolites on
Central Carbon Metabolic Pathway, Amino Acids and
Nucleotides by Triple Quadrupole LC/MS/MS; Tsuyoshi
Nakanishi1; Takako Hishiki2, 3; Makoto Suematsu2, 3;
1
Shimadzu Corporation, Kyoto, Japan; 2School of Medicine,
Keio University, Tokyo, Japan; 3JST ERATO Suematsu Gas
Biology Project, Tokyo, Japan
WP 297 Differential Analysis for Quantitative Metabolomics
Using Isotope-Labeling and LC-HRMS: Data Processing
Strategies; Michel Wagner1; Yasmin Boukhedimi1; Leanne
Ohlund1; Tze Chieh Shiao1; Amelie Vezina1; Borhane
Annabi1; Alex P. Parker2; Sarah Jenna1; Rene Roy1; Lekha
Sleno1; 1UQAM, Montreal, Canada; 2University of Montreal,
Montreal, CA
WP 298 Mild Base Catalyzed Deuteration of Polyphenolics for
Improving their Quantification in Cold Hardy Wines
by Multiple Reaction Monitoring Mass Spectrometry;
Cecilia Gentle1, 2; Mikel Roe1; Adrian Hegeman1; Jerry
Cohen1; 1University of Minnesota, St. Paul, MN; 2AnokaRamsey Community College, Coon Rapids, MN
WP 299 An Isotope Label Free Quantification Method for Plant
Secondary Metabolites by New Developed Make-Up
Liquid Chromatography System; Che-I Liao; Ya-an Lin;
Min-Jane Chen; Kuo-Lung Ku; National Chiayi University,
Chiayi City, Taiwan
WP 300 Separation and Complementary ESI-MS/MS and ICPDRC-MS Detection of Coenzyme A Compounds; Stefan
Neubauer; Dinh Binh Chu; Kristaps Klavins; Stephan Hann;
Gunda Koellensperger; BOKU - Vienna, Vienna, Austria

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WEDNESDAY
POSTERS

WP 301 Addressing the Bottlenecks in Metabolomics: Making
an Expedient Transition from Global Profiling to
Targeted Quantitation; Mark Sanders1; Kevin McHale1;
Adam Takvam2; Michael Athanas3; Mark Szewc1; Jamie
Humphries2; 1Thermo Fisher Scientific NJ, Somerset, NJ;
2
Thermo Fisher Scientific TX, Austin, TX; 3Thermo Fisher
Scientific CA, San Jose, CA
WP 302 Development, Validation and Application of a Novel
UPLC-ESI/MS/MS Method for Simultaneous Quantitative
Profiling of 14 Endocannabinoids in Biological Matrices;
Sandra Gouveia; Malin Nording; Department Chemistry,
Umea University, Umea, Sweden
WP 303 Quantitative and Qualitative Metabolomics of Neuronal
Cell Culture Challenged with Illicit Drugs: A Unified
GC/MS/MS and LC/MS/MS approach; Maria Wenner;
Catherine Rawlinson; Joel Gummer; Ian Mullaney; Garth
Maker; Robert Trengove; Murdoch University, Murdoch,
Australia
WP 304 Use of CI and EI for Enhanced Selectivity and
Sensitivity for the Analysis of Phytohormones; Catherine
Rawlinson1; Lars Kamphuis2; Paul Wynne4, 5; Karam Singh2;
Riki Kitano3; Bruce Fraser4, 5; Robert Trengove 1; 1Murdoch
University, Murdoch, Australia; 2CSIRO Plant Industry, Perth,
Australia; 3Shimadzu Corporation, Tokyo, Japan; 4Shimadzu
Scientific Instruments (Oceania), Palmerston North, New
Zealand; 5Shimadzu Scientific Instruments (Oceania),
Melbourse, Australia
WP 305 Screening of Nandrolone Misuse in Horses by GC-MS/
MS Steroid Profiling and Confirmation by UPLC-MS/
MS Steroid Esters Detection in Blood; Zied Kaabia1, 2;
Gaud Dervilly-Pinel1; Marie-Agnès Popot2; Ludovic BaillyChouriberry2; Philippe Plou2; Yves Bonnaire2; Bruno Le
Bizec1; 1LABERCA, Nantes, France; 2LCH, Paris, France
WP 306 Highly Sensitive Method for Quantification of Estradiol,
Estrone, and Keto-Androgen Metabolites from Human
Serum; Lisa Bottalico1, 2; Kannan Rangiah3; Jasbir Arora4;
Clementina Mesaros1, 2; Ian A. Blair1, 2; 1Center for Cancer
Pharmacology, Philadelphia, PA; 2University of Pennsylvania
School of Medicine, Philadelphia, PA; 3NCBS, Center for
Cellular and Molecular Platforms, Bangalore, India; 4HFL
Sport Science, LGC Health Sciences, KY
WP 307 Comprehensive Analysis of Neurotransmitters from
Planarian Extract Using UHPLC-MS/SRM Method;
Kannan Rangiah1; Dasaradhi Palakodeti2; 1Scientist,
C-CAMP, Bangalore, India; 2Scientist, inSTEM, Bangalore,
India
WP 308 Metabolomics Investigation of Ovalbumin-Induced
Murine Asthmatic Model; Jun Yang; Jennifer Bratt; Lisa
Franzi; Nicholas Kenyon; Bruce Hammock; University of
California, Davis, CA
WP 309 Investigation of Gender Differences in the Hepatic
Metabolome of Genotyped Sockeye Salmon
(Oncorhynchus nerka) Using a Targeted Metabolomics
Approach; Jonathan Benskin1, 2; Michael Ikonomou2; Ralf
Bogumil3; John Cosgrove1; 1AXYS Analytical Services Ltd.,
Sidney, Canada; 2Institute of Ocean Sciences, Sidney,
Canada; 3BIOCRATES Life Sciences AG, Innsbruck, Austria
WP 310 Dynamics of Acylsugar Biosynthesis and Metabolism in
Solanum Glandular Trichome Development; Zhenzhen
Wang; A.Daniel Jones; Michigan State University, East
Lansing, MI
WP 311 Targeted Metabolomic Analysis of Nucleosides
in Biological Fluids by Isotope Dilution Liquid
Chromatography Electrospray Ionization Tandem Mass
Spectrometry; Jaeman Byun; Anna Mathew; Subramaniam
Pennathur; University of Michigan, Ann Arbor, MI

PAGE 132					

Metabolomics: Clinical Applications, 312 – 323
WP 312 Metabolomic Profiling Reveals Biochemical Pathways
Associated with Ethnic Disparity in Breast Cancer;
Nagireddy Putluri1; Atsushi Terunuma2, 3; Tim D. Veenstra4;
Prachi Mishra2, 3; Ewy A. Mathe2, 3; Tiffany H. Dorsey4; Ming
Yi4; Tiffany A. Wallace4; Haleem J. Issaq4; J. Keith Killian4;
Holly S. Stevenson4; Edward D. Karoly5; King Chan4;
Susmita Samanta1; Daniel C. Edelman4; Jacob Wulff4;
Adrienne M. Starks2, 3; Yinmeng Yang2, 3; Rick A. Kittles6;
Harry G. Yfantis7; Dong H. Lee7; Rachel Schiff1; Robert
M. Stephens4; Paul S. Meltzer4; Arun Sreekumar1; Stefan
Ambs4; 1Baylor College of Medicine, Houston, TX; 2National
Institutes of Health, Bethesda, MD; 3National Institutes of
Health, Bethesda, MD; 4National Cancer Institute, Bethesda,
MD; 5Metabolon Inc, Durham, NC; 6University of Illinios,
Chicago, IL; 7Pathology and Laboratory Medicine, Baltimore,
MD
WP 313 Application of Metabolomics to Characterize
Differences between Plasma and Nipple Aspirate
Fluid, a Potential Source of Novel Breast Cancer
Biomarkers; Jessica Miller1; Patricia Thompson1; Andrew
Baker2, 3; Steven Lai2, 3; H-H Sherry Chow1; 1University of
Arizona Cancer Center, Tucson, AZ; 2Waters Corporation,
Pleasanton, CA; 3Waters Corporation, Milford, MA
WP 314 Metabolomic Comparison of Serum Changes in Focal
Segmental Glomerulosclerosis (FSGS) – Preliminary
Study; Chih-Chuan Yu1; Chen-Chin Chang1; Lai-Chuan
Chang 1; Hung-Chun Chen2; 1Biotech Total Solutions
Co., Ltd., Taipei, Taiwan; 2Kaohsiung Medical University,
Kaohsiung, Taiwan
WP 315 MALDI-TOF MS Quantitation of Targeted Metabolite
Disease Markers from Human Plasma; Nivedita
Bhattacharya1; Ajeet Singh1; Avinash Ghanate1; Gaurav
Bharadwaj2; Trayambak Basak2; Shantanu Sengupta2;
Venkateswarlu Panchagnula1; 1CSIR-National Chemical
Laboratory, Pune, India; 2CSIR-Institute of Genomics and
Integrative Biology, New Delhi, India
WP 316 Metabolomic Study of Malaria-Borrelia Co-Infection in
Murine Model; Izabella Surowiec1; Maria Nelson2; Sven
Bergström2; Johan Trygg1; Johan Normark2; 1Department of
Chemistry, Umeå University, Umeå, Sweden; 2Department
of Molecular Biology, Umeå University, Umeå, Sweden
WP 317 A Global LC-MS Metabolomics Approach for Biomarker
Identification in Patients with Nonalcoholic Fatty
Liver Disease; Rainey Patterson1; Romina Lomonaco2;
Nishanth Sunny2; Kenneth Cusi2; Timothy Garrett3; David
Powell1; Richard Yost1; 1Department of Chemistry, University
of Florida, Gainesville, FL; 2Division of Endocrinology,
University of Florida, Gainesville, FL; 3Department of
Pathology, University of Florida, Gainesville, FL
WP 318 Evaluation of Home Sampling DBS and Micro Fluidic
LC/MS for Monitoring the Effects of Rosuvastatin on
Cholesterol and Triglyceride Levels; Robert Plumb1; Ian
Wilson1; Nicola Gray1; Paul Rainville2; 1Imperial College,
London, UK; 2Waters, Milford, MA
WP 319 Determination of Hydroxyeicosatetraenoic Acids in
Prostate Cancer Serum Samples Using UHPLC-MS/
MS; Giovanny Rodríguez-Blanco1; Peter Burgers1; Lennard
Dekker1; Jan Ijzerman2; Mirella Vredenbregt-van den Berg3;
Ellen Schenk3; Guido Jenster3; Theo Luider1; 1Neurology
Department, Erasmus Medical Center, Rotterdam,
Netherlands; 2Department of Surgery, Erasmus Medical
Center, Rotterdam, Netherlands; 3Urology Department,
Erasmus Medical Center, Rotetrdam, Netherlands
WP 320 Plasma Metabolites Associated with Acute
Exacerbations of Chronic Obstructive Pulmonary
Disease; Makedonka Gulcev1; Cavan Reilly1; Steven

61ST ASMS CONFERENCE ON MASS SPECTROMETRY

WEDNESDAY POSTERS

Harvey1; Joseph Dalluge1; Prescott Woodruff2; Christine
Wendt1; 1University of Minnesota, Minneapolis, MN;
2
University of California, San Francisco, CA
WP 321 Assessment of Gut Microbiome Using Metabolomics
Analysis of Body Fluids; Shucha Zhang; Karen Corbin;
Xueqing Zhao; Steven Zeisel; UNC Chapel Hill, Kannapolis,
NC
WP 322 Identification of Metabolites Cleared by the Kidney with
High Efficiency Using Orbitrap Metabolomics Platform;
Pavel Aronov1; Tammy Sirich2; Natalie Plummer2; Allis
Chien3; Timothy Meyer2; 1Thermo Scientific, San Jose, CA;
2
Department of Medicine, Stanford University, Stanford,
CA; 3Mass Spectrometry Laboratory, Stanford University,
Stanford, CA
WP 323 Metabolomics Input in a Search for Chronic Kidney
Disease Targets Utilizing Clinical Cross-Platform Omics
Data Integration; Vladimir Tolstikov; Alexander Nikolayev;
Dennis Laska; Ming-Shan Kuo; Kevin Duffin; Eli Lilly and
Company, Indianapolis, IN
Food “omics” MS Characterization of Food and
Nutritional Supplements, 324 – 355
WP 324 An Advanced CE-QTOF Technique for the Rapid
Characterization of Amino Acids in Herbal Medicines;
Tao Bo; Zhengxiang Zhang; Xiaorong Ran; Jianzhong Li;
Agilent Technologies, Beijing, China
WP 325 Sake-omics: Development and Application of Advanced
GC-MS Methods for Speciation of Quality Components
in Sake Varietals; Doug D. Carlton Jr; Kevin A. Schug; The
University of Texas at Arlington, Arlington, TX
WP 326 Rapid Analysis of Triglycerides and Fatty Acids in
Food Oils Using DART-MS with High-Speed Polarity
Switching; Shun Wada1; Jun Watanabe2; Keiko
Matsumoto2; Teruhisa Shiota3; Shingo Toda3; 1Japan Inst.
of Oil & Fats, Other Foods Inspection, Tokyo, Japan;
2
Shimadzu Corporation, Kyoto, Japan; 3AMR, Inc., Tokyo,
Japan
WP 327 Quantitative Analysis of α- and β- acids in Hops by
Paper Spray Ionization; Gregg Hasman; Andre Venter;
Western Michigan University, Kalamazoo, MI
WP 328 Rapid Amino Acid Content Analysis in Soybeans
and Other Foodstuffs Utilizing Microwave Hydrolysis
Coupled with Desorption Electrospray Ionization
Mass Spectrometry; Jonathan R. Person; Christopher C.
Mulligan; Department of Chemistry, Illinois State University,
Normal, Il
WP 329 New Method for the Analysis of Antioxidants in
Vegetable Oils Using an Hybrid SFC/UHPLC System
with MS Detection; Patric Hoerth1; Maria RamblaAlegre2; Martin Vollmer1; Gerd Vanhoenacker2; 1Agilent
Technologies, Waldbronn, Germany; 2Research Institute for
Chromatography, Kortrijk, Belgium
WP 330 Use of Supercritical Fluid Chromatography /Mass
Spectrometry for Rapid Separation of Fat Soluble
Vitamins, A, D, E and K ; Jennifer Van Anda1; Terry
Berger2; 1Agilent Technologies, Little Falls, DE; 2SFC
Solutions, Englewood, FL
WP 331 Analysis of Water-Soluble B Vitamins in Infant Formula
Using Automated Online Sample Preparation with LC/
MS; Yang Shi; Thermo Fisher Scientific, Franklin, MA
WP 332 Queued and Ready to Run? Testing the Stability
of Vitamin Extracts While in Queue Using Triple
Quadrupole LC/MS/MS Analysis; Jeremy Post 1; Susan
Leonard2; Christopher Gilles1; Scott Kuzdzal1; 1Shimadzu
Scientific Instruments, Columbia, MD; 2Shimadzu Scientific
Instruments., Marlborough, MA

WP 333 Characterization of Flavored Tobacco with GCxGCTOFMS and GC-HR-TOFMS; Elizabeth Humston-Fulmer;
Jeff Patrick; Joe Binkley; LECO, St. Joseph, MI
WP 334 High Throughput Profiling of Phytic Acid, Inositol
Phosphates and Inorganic Phosphate in Seed Extracts
with Flow Injection Electrospray Mass Spectrometry;
David Mccaskill; Josh Flook; Scott Greenwalt; Beth
Blakeslee; Dow AgroSciences, Indianapolis, IN
WP 335 LC-MS Analysis of Food and Food Additives with
Monolithic Silica Columns; David Lentz1; Stephan
Altmaier2; Egidijus Machtejevas2; Karin Cabrera2; 1EMD
Millipore, Billerica, MA; 2Merck Millipore Merck KGaA,
Darmstadt, Germany
WP 336 Characterization and Quantitation of Capsaicin and
Related Pungent Agents in Chili Peppers and Hot
Sauces by LC/MS/MS; Seyed Sadjadi; J Preston; Sky
Countryman; Zeshan Aqeel; Phenomenex, Inc, Torrance,
CA
WP 337 Comprehensive Analysis of Caecal Contents of the
Human Flora-associated (HFA) Mice by High Resolution
LC-QTOF Mass Spectrometry; Masahiko Takino1; Motoi
Tamura2; 1Agilent Technologies Japan, Tokyo, Japan; 2the
National Food Research Institute, Tsukuba, Japan
WP 338 Elemental Non-Targeted Profiling of 66 Whiskies Using
ICP-MS; Helene Hopfer1, 2; Thomas S. Collins1, 3; Jenny
Nelson2, 4; Susan Ebeler1, 2; 1UC Davis, Davis, CA; 2Food
Safety and Measurement Facility, Davis, CA; 3Treasury
Wine Estates, Napa, CA; 4Agilent Technologies, Santa
Clara, CA
WP 339 Metabolic Profiling of Wines from Various Geographic
Regions and Chateaux Using UHPLC-ESI/QTOF-MS
Technique Combined with Principle Components
Analysis; Shen Han1; Jinhua Wang1; Ying Liu1; Qi Zhou1;
Meiling Lu2; 1Beijing Entry-Exit Bureau of Inspect. and
Quarant., Beijing, CN; 2Agilent Technologies, Beijing, CN
WP 340 Application of Non-Targeted High Resolution Mass
Spectrometry to Monitoring Tea Fermentation Level and
Origin; Karl Fraser2; Don Otter2; Geoff Lane2; Siew-Young
Quek1; Yacine Hemar1; 1University of Auckland, Auckland,
New Zealand; 2AgResearch, Palmerston North, New
Zealand
WP 341 A Novel Strategy for in situ Label-Free Imaging of a
Bioactive Polyphenol; Yoshinori Fujimura1; Yoon Hee
Kim2; Takatoki Hagihara2; Masako Sasaki2; Daichi Yukihira2;
Tatsuhiko Nagao2; Daisuke Miura1; Shinichi Yamaguchi3;
Kazunori Saito4; Hiroyuki Wariishi2; Koji Yamada2; Hirofumi
Tachibana2; 1ICMRN, Kyushu University, Fukuoka, Japan;
2
Faculty of Agriculture, Kyushu University, Fukuoka, Japan;
3
Shimadzu Corporation, Kyoto, Japan; 4Bruker Daltonics
K.K., Yokohama, Japan
WP 342 Identification of Structural Isomers of Methylated
Flavonols by UHPLC Coupled High Resolution QTOF
Mass Spectrometry; ChengYing Ma1; Haipeng Lv1;
Xingzhong Zhang1; Zongmao Chen1; Jiang Shi1; Zhi Lin1;
Meiling Lu2; Shan Zhou2; 1Tea Research Institute, CAAS,
Hangzhou, CN; 2Agilent Technologies, Beijing, CN
WP 343 A Global Proteomics Approach for the Detection and
Characterization of Gluten in Food; Katherine L. Fiedler;
Sara C. McGrath; John H. Callahan; Mark M. Ross;
CFSAN, U.S. FDA, College Park, MD
WP 344 Characterization and Quantification of Peanut
Allergens Using Ion Mobility Data Independent Label
Free Strategies; Philip Johnson2; Lee A Gethings1;
Justin Marsh2; James Langridge1; Clare Mills2; 1Waters,
Manchester, UK; 2University of Manchester, Manchester, UK

61ST ASMS CONFERENCE ON MASS SPECTROMETRY						

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GENERAL
INFORMATION
WEDNESDAY
POSTERS

WP 345 Site-Specific Detection of Radicals on α-lactalbumin
after riboflavin-Sensitized Reaction, Detected by
Immuno-Spin Trapping, ESR and MS; Trine Dalsgaard1;
Mathilde Triquigneaux2; Leesa Deterding2; Fiona Summers2;
Kalina Ranguelova2; Grith Mortensen1; Ronald Mason2;
1
Aarhus University, Tjele, Denmark; 2NIEHS/NIH, Research
Triangle Park, NC
WP 346 Identification of AGE Modifications to Peanut Allergens
Using LC-ESI Based Mass Spectrometry; Katina L.
Johnson 1; Geoffrey A. Mueller1; Soheila Maleki2; Allison
Schrozman3; Anna Pomes4; Lori Edwards1; Hajeung Park5;
Leesa Deterding1; Kenneth B. Tomer1; Robert London1;
Jason G. Williams1; 1National Institute of Environmental
Health Science, Reseach Triangle Park, NC; 2USDA, New
Orleans, LA; 3University of North Carolina at Chapel Hill,
Chapel Hill, NC; 4INDOOR Biotechnologies, Charlottesville,
VA; 5The Scripps Research Institute, Jupiter, FL
WP 347 Rapid Throughput Extraction of Human Milk
Oligosaccharides to Allow Studies on Larger Cohorts;
Lauren M. Dimapasoc; Sarah Totten; Carol Stroble; L.
Renee Ruhaak; Carlito B. Lebrilla; University of California,
Davis, CA
WP 348 Milk Protein Identification and Relative Quantification
by Capillary LC Coupled with Novel Hybrid High
Resolution Mass Spectrometer; Terry Zhang; David
Horn; Guifeng Jiang; Charles Yang; Dipankar Ghosh;
ThermoFisher, San Jose, CA
WP 349 Mass Spectrometry Based Glycan Arrays for
Determining Specificity of Glycosidases in Bacteria;
Sarah Totten; Santiago Ruiz-Moyano; David Mills; Carlito
Lebrilla; University of California, Davis, CA
WP 350 Digestomics of Human Milk Proteins in Term and
Premature Infants; David Dallas1; Andres Guerrero1; Nora
Khaldi2; Bruce German1; Daniela Barile1; Mark Underwood1;
Carlito Lebrilla1; 1University of California, Davis, CA; 2UC
Dublin, Dublin, Ireland
WP 351 Metabolite Fingerprinting Using High Resolution Mass
Spectrometry of Feces from Rats Fed Resistant Starch;
Tim Anderson; R. Sam Houk; Roger Jones; Diane Birt;
Yinsheng Zhao; John McClelland; Iowa State University,
Ames, IA
WP 352 Determination of fortified and endogenous folates
in food-based Standard Reference Materials by
isotope-dilution liquid chromatography-tandem mass
spectrometry; Johanna Camara; Mark Lowenthal; Karen
Phinney; NIST, Gaithersburg, MD
WP 353 Analysis of Triglycerides in Plant Oils by Direct
Analysis in Real Time; Igor Gavin; Anil Oroskar; Asha
Oroskar; Orochem Technologies Inc., Lombard, IL
WP 354 A New, Sensitive Method for Lignan Metabolite
Detection of Flaxseed-Fed Mice Using LC-MS/MS; Rong
Tsao1; Honghui Zhu1; Sha Joshua Ye2; Lisa M. Cousins
2 1
; Guelph Food Research Centre, Agriculture & Agri-F,
Guelph, ON, Canada; 2IONICS Mass Spectrometry, Bolton,
ON, Canada
WP 355 Identification of Wax Esters by LCMS in Cloudy Canola
Oil; Susan Seegers; Tiffanie West; Bunge North America,
Bradley, IL

WP 358

WP 359

WP 360

WP 361

WP 362

WP 363

WP 364

WP 365

WP 366

WP 367

Food Safety, 356 – 372
WP 356 Determination of 3-chloro-1,2-propanediol in Soy Sauce
Samples with Supported Liquid Extraction and GC-MS;
Suzi Qin; Jack Liu; Wan Wang; Guotao Lu; Bonna-Agela
Technologies, Tianjin, China
WP 357 Direct Detection of Chloramphenicol in Honey by
Neutral Desorption-Extractive Electrospray Ionization
Mass Spectrometry; Xi Zhang1, 2; Li-Ping Luo2; Xi-Mo Dai1,

PAGE 134					

; Xiao-Wei Fang1; Eric Handberg1; Huanwen Chen1; 1East
China Institute of Technology, Nanchang, China; 2Nanchang
University, Nanchang, China
Rapid Screening of Sulfur fumigated Chinese Star
Anise by Surface Desorption Atmospheric Pressure
Chemical Ionization Mass Spectrometry; Xi-Mo Dai1,
2
; Li-Ping Luo1; Xi Zhang1, 2; Ya-Li Liu2, 3; Xiao-Wei Fang2;
Eric Handberg2; Huanwen Chen2; 1Nanchang University,
Nanchang, China; 2East China Institute of Technology,
Nanchang, Chinia; 3Hebei University of Technology, Tianjin,
China
Cadmium-Lead Chemical Signatures Characteristic to
the Harvest Areas of the American Oyster, by ICP-MS: A
Regulatory and Environmental Monitoring Tool; Marc E.
Engel; FDACS, Tallahassee, FL
Liquid Chromatography – Mass Spectrometry Method
for the Quantitative Determination of Residues of
Selected Veterinary Hormones in Powdered MilkBased Commodities; Stefan Ehling; Murali Reddy; Abbott
Nutrition, Columbus, OH
Direct-EI/LC-MS in Food Safety Applications.
Multicomponent Analysis of Environmental
Contaminant Residues in Milk Based Raw Materials;
Achille Cappiello1; Fabiana Capriotti1; Giorgio Famiglini1;
Pierangela Palma1; Veronica Termopoli1; Nicholas Cellar2;
1
University of Urbino, Urbino, Italy; 2Abbott Nutrition,
Columbus, OH
Rapid Quantitative Detection of Residual Malachite
Green in Drinking and Aquiculture Water Samples by
Extractive Electrospray Ionization Mass Spectrometry
(EESI-MS); Xiaowei Fang; Susu Pan; Liang Zhu; Xinglei
Zhang; Eric Handberg; Huanwen Chen; East China Institute
of Tech., Nanchang, China
Coupling Neutral Desorption to Dielectric Barrier
Discharge Ionization Mass Spectrometry for Direct
Analysis of Oil Samples; Yafei Zhou1; Zhongchen Wu2;
Cao Li1; Nannan Wang1; Saijin Xiao1; Xinglei Zhang1; Eric
Handberg1; Huanwen Chen1; 1East China Institute of Tech.,
Nanchang, China; 2Shandong University, Weihai, China
Desorption Atmospheric Pressure Chemical Ionization
Mass Spectrometry and Pattern Classification to
Identify the Molecular Cause of Aging in Lotus Seeds;
Ximo Dai1, 3; Liping Luo1, 1; Xi Zhang1, 3; Yongzhong Ouyang2;
Eric Handberg3; Huanwen Chen3; 1Nanchang University,
Nanchang, China; 2Hebei University of Technology, Tianjin,
China; 3East China Institute of Tech., Nanchang, China
Analysis of α-dicarbonyl Process Contaminants in
High Fructose Corn Syrup and Carbonated Soft Drinks
by UHPLC-DAD-ESI-MS/MS; Sabrina Gensberger;
Monika Pischetsrieder; University of Erlangen-Nuremberg,
Erlangen, Germany
Multi-Target Screening for 138 Veterinary Drugs in
Meat Using Liquid Chromatography High Resolution
Mass Spectrometry; Feng Qin1; Xiaoyan Li1; Ke Wang1;
Chengyuan Cai2; Yongming Xie2; Huaien Zhu2; 1Shanghai
Institute of Food and Drug Control, Shanghai, China;
2
ABSCIEX, Shanghai, China
Rapid Identification of Veterinary Drugs from Different
Matrices Using High Resolution LC/MS/MS and Library
Search; Franziska Spitzbarth1; Günther Kempe1; Jianru
Stahl-Zeng2; Alexander Eilfeld2; 1LUA Sachsen, Chemnitz;
2
AB Sciex, Leipzig, Germany
Determination of 68 Veterinary Drugs in Marine
Products by Ultra High Performance Liquid
Chromatography/Triple Quadrupole Mass
Spectrometry; Lingling Shen; Jinting Yao; Caiyong Lin;
Xiongxiong Qiu; Qisheng Zhong; Song Zhan; Taohong
2

WP 368

61ST ASMS CONFERENCE ON MASS SPECTROMETRY

WEDNESDAY POSTERS

WP 369

WP 370

WP 371

WP 372

Huang; Shimadzu Global COE, Shimadzu (China) Co., Ltd.,
Guangzhou, China
Analysis of Multiclass Veterinary Drug Residues in
Baby Food by Ultra Fast Chromotagraphy with High
Performance Triple Quadropole Mass Spectrometry;
Charles T. Yang; Mary Blackburn; Dipankar Ghosh; Thermo
Fisher Scientific, San Jose, CA
Multi-residue Screening and Confirmation of Veterinary
Drugs in Tissue Samples by LC-MS/MS with New
Triggered MRM Acquisition; Guenther Kempe2; Thomas
Glauner1; Franzika Spitzbarth2; 1Agilent TechnologiesGmbH,
Waldbronn, Germany; 2LUA Saxony, Chemnitz, Germany
Automated Solid Phase Extraction (SPE)-LC/MS/
MS Method for the Determination of Acrylamide in
Brewed Coffee Samples; Fred Foster; John Stuff; Edward
Pfannkoch; Gerstel, Inc., Linthicum, MD
Organizing the Masses; Daniel L. Sweeney; MathSpec,
Inc., Arlington Heights, IL
H/D Exchange, Software and Hardware, 373 – 385

WP 373 Peptide-Dependent Amide Back Exchange Rates Limit
the Utility of Subtractive Analysis as a Method for
Increased HDX-MS Resolution; Joey Sheff; University of
Calgary, Calgary, Canada
WP 374 Assessing Lab-to-lab Reproducibility of Deuterium
Measurement in Hydrogen Deuterium Exchange Mass
Spectrometry Analysis; Barbara Sullivan; Waters, Beverly, MA
WP 375 Online SCX and RP extraction method for H/D
Exchange Mass Spectrometry of Samples Containing
Macromolecular Crowding Agents; Farai Rusinga; David
Weis; University of Kansas, Lawrence, KS
WP 376 An Improved HDX Platform Workflow for Enhanced
Separation, Digestion, and Data Analysis; Joomi
Ahn1; Michael Eggertson1; Keith Fadgen1; Han Joo Lee1;
John Engen2; 1Waters Corp, Milford, MA; 2Northeastern
University, Boston, MA
WP 377 Applications of an Automated Hydrogen Deuterium
Exchange Platform to Epitope Mapping of AntibodyAntigen Complexes; Jon Fitchett; Kai Zhang; Bryan E
Jones; Lilly Biotech Center-San Diego, San Diego, CA
WP 378 Overcoming Peak Capacity Limitations Imposed by
Hydrogen Exchange Quench Conditions; Bradley
B. Stocks1; Thomas E. Wales1; Martha Stapels2; Keith
Fadgen2; Michael Eggertson2; Geoff Gerhardt2; John R.
Engen1; 1Northeastern University, Boston, MA; 2Waters
Corporation, Milford, MA
WP 379 A Single-Droplet Digital Microfluidics System for
Hydrogen-Deuterium Exchange Mass Spectrometry;
Huijiang Ding; Puneet Souda; Christopher M. Ryan; Kym
Faull; Julian Whitelegge; University of California, Los
Angeles, CA
WP 380 Fully Automated HDX-MS on a Microfluidic Platform
– Solving Problems Related to Small Volume Sample
Preparation, Protein Adsorption, and Carryover; Yunan
Miao1; Gregory Staples2; Reid A. Brennen2; Hongfeng
Yin2; Kevin Killeen2; Terry Lee1; 1City of Hope, Duarte, CA;
2
Agilent Laboratories, Santa Clara, CA
WP 381 Software for Automated HDX-MS Data Analysis and
Visualization; Seungjin Na1; Jae-Jin Lee2; Kong-Joo Lee2;
Eunok Paek1; 1Hanyang University, Seoul, Korea; 2Ewha
Womans University, Seoul, Korea
WP 382 How to Obtain Conformational Structures of Protein
in Solution from Higher Charge States in HDX and
Top-Down ECD ESI MS? Teerapat Rojsajjakul; Fred
King; Department of Chemistry, West Virginia University,
Morgantown, WV

WP 383 H/D Exchange Mass Spectrometry in Atmospheric
Pressure ESI-MS Interface for Enumeration of Labile
Hydrogens in Complex Mixtures; Yury Kostyukevich1,
4
; Alexey Kononikhin1, 2; Igor Popov2, 4; Oleg Kharybin1,
3
; Eugene Nikolaev1, 3; 1Institute for Energy Problems of
Chemical Physics, Moscow, Russia; 2Emanuel Institute of
Biochemical Physics, Moscow, Russia; 3Orekhovich Institute
of Biomedical Chemistry, Moscow, Russia; 4Moscow
Institute of Physics and Technology, Moscow, Russia
WP 384 Improvements to the HDX Workbench Software for High
Throughput Analysis of HDX MS Data; Bruce D. Pascal;
Michael J. Chalmers; Graham M. West; Scott Novick;
Devrishi Goswami; David Marciano; Patrick R. Griffin; The
Scripps Research Institute, Scripps Florida, Jupiter, FL
WP 385 Binomial Fitting Provides a Powerful Method for the
Analysis of H/D Exchange Data; Miklos Guttman; Kelly
Lee; University of Washington, Seattle, WA
H/D Exchange: Protein Structure/Function II, 386 – 400
WP 386 Structural Confirmation of Potential Cancer
Therapeutic: Pyruvate Kinase Activator Restores
Active Conformation to M2 Isoform; Graham M West 1;
Dimitrios Anastasiou2; Bruce Pascal1; Michael Chalmers1;
Lewis Cantley3; Patrick Griffin1; 1Scripps Research Institute,
FL, Jupiter, FL; 2Division of Physiology and Metabolism,
MRC-NIMR, London, UK; 3Dpt of Systems Biology, Harvard
Medical School, Boston, MA
WP 387 Using Hydrogen-Deuterium Exchange to Probe the
Structure of Phosphorylase Kinase, a Complex with 325
kDa of Unique Sequence; Mary Ashley Rimmer; Antonio
Artigues; Maria T. Villar; Gerald M. Carlson; University of
Kansas Medical Center, Kansas City, KS
WP 388 Substrate Channeling in PhosphodiesteraseProtein Kinase A interactions Mediates cAMP Signal
Termination: Monitoring Transient Ternary Complexes
by HDXMS; Srinath Krishnamurthy; NUS, Singapore
WP 389 Structural Dynamics and Ligand Depended Activation
of IDH1 R132H Probed by HDX-MS; Devrishi Goswami1;
Michael Chalmers1; Carlos Perez2; Stephen Antonysamy2;
Bruce Pascal1; Jeffrey Dodge2; Patrick Griffin1; 1The Scripps
Research Institute, Jupiter, FL; 2Lilly Research Laboratories,
Eli Lilly and company, Indianapolis, IN
WP 390 H/DX Mass Spectrometry Reveals Features of SecA
Dimeric Interface and a Conformational Change from
Open to Closed Forms upon Dimerization; Yuetian Yan1;
Andy Wowor2; Jun Zhang3; James Cole4; Debra Kendall5;
Michael Gross1; 1Dept of Chemistry, Washington University,
Saint Louis, MO; 2Dept of Chem and Biochem, Colorado
College, Colorado Springs, CO; 3Department of Drug
Product Development, Amgen Inc, Seattle, WA; 4Department
of Chemistry, University of Connecticut, Storrs, CT; 5Dept of
Pharmaceutical Sciences, U. of Connecticut, Storrs, CT
WP 391 Thermodynamic Stability of Protective Antigen
Measured by His-HDX-MS; Vennela Mullangi1, 3; James
Bann2; David Anderson1; Masaru Miyagi3; 1Cleveland State
University, Cleveland, OH; 2Wichita State University, Wichita,
KS; 3Case Western Reserve University, Cleveland, OH
WP 392 Characterizing Protein Dynamics and Higher Order
Structure in a Conformer-Specific Fashion with TopDown HDX MS/MS: A Case of Ubiquitin; Guanbo Wang;
Rinat R. Abzalimov; Igor A. Kaltashov; University of
Massachusetts, Amherst, MA
WP 393 Effect of Ligand binding on Conformational Dynamics
of DAHP Synthase Using Microfluidics Enabled
Hydrogen/ Deuterium Exchange; Tamanna Rob1; Naresh
Balachandran2; Paul Berti2; Derek Wilson1; 1York University,
Toronto, Canada; 2McMaster University, Hamilton, ON, Canada

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WEDNESDAY
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WP 394 HDX-MS in Pharmaceutical Analysis: Defining the
Epitopes of Drug-Bound Proteins; Rebecca Rose;
Hannah Maple; John Porter; Richard Taylor; Rachel Garlish;
UCB, Slough, UK
WP 395 Pinpointing Conformational Differences between
Protein Variants by HDX-MS and ETD (HDX-ETD); Signe
T. Seger1, 2; Mette D. Andersen2; Jens Breinholt2; Christine
B. Schjødt2; Johan Faber2; Kasper D. Rand1; 1University of
Copenhagen, Copenhagen, Denmark; 2Novo Nordisk A/S,
Biopharmaceuticals Research Unit, Måløv, Denmark
WP 396 Solution-Phase H/D Exchange for Charge State +12 and
+13 Ions of Bovine Ubiquitin Revealed by Top-down
ECD ESI FTICR MS; Xiaqing Xu; Teerapat Rojsajjakul; Fred
King; Department of Chemistry, West Virginia University,
Morgantown, WV
WP 397 Analysis of cGMP/cAMP Binding to the PKGI Beta
Regulatory Domain by HDX Using High Resolution
Orbitrap Mass Spectrometer; Sheng Li; Bryant Kou; Virgil
Woods, Jr; Darren E. Casteel; UCSD, La Jolla, CA
WP 398 Probing Inhibition of Insulin Fibrillation by 1, 2-Bis[4(3-sulfonatopropoxyl)phenyl]-1,2-Diphenylethene with
Hydrogen/Deuterium Exchange – Mass Spectrometry;
Matthew Cummings; Teerapat Rojsajjakul; Fred King;
Department of Chemistry, West Virginia University,
Morgantown, WV
WP 399 A HDX/MS Analysis of the Interaction between Human
Tumor Necrosis Factor-Alpha (TNF-alpha) and anti-TNFalpha Agents; Shiori Nakazawa1, 2; Noritaka Hashii2; Nana
Kawasaki1, 2; 1Hokkaido Univ., Sapporo, Japan; 2Natl. Inst.
Health Sci., Tokyo, Japan
WP 400 Suicide Inhibition of Oncogenic K-Ras G12C Proceeds
via Shift to the Inactive Conformation; Rane Harrison1;
Sang Min Lim2, 3; Kenneth Westover4; Nathanael Gray2,
3
; John Engen1; 1Northeastern University, Boston, MA;
2
Harvard Medical School, Boston, MA; 3Dana-Farber Cancer
Institute, Boston, MA; 4University of Texas Southwestern
Medical Center, Dallas, TX
Proteins: Non-Covalent Interactions, 401 – 421
WP 401 Assembly of the Bacteriophage T7 Replisome Probed
by Native Electrospray Ionization Top-Down Mass
Spectrometry; Hao Zhang; Jamie R. Wallen; Weidong Cui;
Robert E. Blankenship; Thomas E. Ellenberger; Michael L.
Gross; Washington University, St. Louis, MO
WP 402 Probing the Molecular Mechanism of Photoprotective
Quenching in Cyanobacteria by Native Mass
Spectrometry and Protein Cross-linking; Hao Zhang;
Haijun Liu; Mindy Prado; Michael L. Gross; Robert E.
Blankenship; Washington University, Saint Louis, MO
WP 403 Nanodiscs Can Fly: Investigating the Ionization
and Dissociation Mechanisms of Lipoprotein
Macromolecules; Michael Marty1; Hao Zhang2; Weidong
Cui2; Robert Blankenship2; Michael Gross2; Stephen Sligar1;
1
University of Illinois Urbana-Champaign, Urbana, IL;
2
Washington University St. Louis, St. Louis, MO
WP 404 Binding Affinities Determination of the Norovirus P
Particle with HBGA Oligosaccharides; Ling Han1; Elena
Kitova1; Ming Tan2; Xi Jiang2; John Klassen1; 1University of
Alberta, Edmonton, Canada; 2Cincinnati Children’s Hospital
Medical Center, Cincinnati, OH
WP 405 Quantification of Protein Binding to Cell Receptors
by Electrospray Ionization Mass Spectrometry; Hong
Lin; Yixuan Zhang; Elena N. Kitova; John S. Klassen;
Department of Chemistry, Univrsity of Alberta, Edmonton,
Canada

PAGE 136					

WP 406 Dissociation Pathways Observed for Multisubunit
Protein-Ligand Complexes in the Gas Phase; Yixuan
Zhang; Lu Deng; Elena Kitova; John Klassen; U of Alberta,
Edmonton, Canada
WP 407 A Novel Method for Determining the Binding Site
Location of FGFR1 Kinase Inhibitors; Helen Beeston1;
Jan Griesbach2; Jason Breed2; Richard Norman2; Julie
Tucker2; Geoff Holdgate2; Alison E. Ashcroft1; 1Faculty
of Biological Sciences,University of Leeds, Leeds, UK;
2
Astrazeneca UK Ltd, Macclesfield, UK
WP 408 Probing Interactions of Different Glycoforms of
Antithrombin-III with Heparin Octasaccharides Using
Native Electrospray Ionization Mass Spectrometry ;
Rinat Abzalimov; Burcu Baykal; Stephen Eyles; Paul Dubin;
UMASS, Amherst, MA
WP 409 Investigation of the Interaction between Gadolinium and
Transferrin by Mass Spectrometric Analysis; Kristina
Wentker; Christine Brauckmann; Olga Reifschneider;
Helene Faber; Christoph A. Wehe; Uwe Karst; University of
Münster, Münster, Germany
WP 410 Determination of Non-Covalent Bound Ligands and
Metals to Transferrin in Clinically Relevant Samples;
Jake W. Pawlowski; Cedric E. Bobst; Igor A. Kaltashov;
UMASS, Amherst, MA
WP 411 Mass Spectrometry Reveals Synergistic Binding
of Nucleotides, Lipids and Drugs to a Multidrug
Resistance Efflux Pump; Julien Marcoux1; Sheila Wang1;
Argyris Politis1; Jerome Ma1; Philip Biggin1; Geoffrey
Chang2; Nina Morgner1; Carol V. Robinson1; 1University of
Oxford, Oxford, UK; 2Scripps Research Institute, La Jolla,
CA
WP 412 Pulsed and Continuous Infrared Laser
Photodissociation of Soluble and Membrane Protein
Complexes in a Modified QToF Mass Spectrometer;
Victor A. Mikhailov1; Todd Mize1; Matt Bush2; Carol
Robinson1; 1University of Oxford, Oxford, UK; 2University of
Washington, Seattle, US
WP 413 Improved Structural Characterization of Stable NonCovalent Protein Complexes by Surface Induced
Dissociation (SID); Xin Ma; The Ohio State University,
Columbus, OH
WP 414 Probing Protein-Ligand Interactions Involved in
Neurodegenerative Disease Using Native Electrospray
Ionization Top-Down Mass Spectrometry; Piriya
Wongkongkathep; Sheng Yin; Becky Chan; Madhuri
Chattopadhyay; Joan Valentine; Gal Bitan; Joseph Loo;
UCLA, Los Angeles, CA
WP 415 Structural Characterization of Protein Complexes by
Electron Capture Dissociation and Top-Down Native
Mass Spectrometry; Jiang Zhang; G. Reza Malmirchegini;
Robert Clubb; Joseph Loo; Univ. California, Los Angeles,
CA
WP 416 Fourier Transform Ion Cyclotron Resonance Mass
Spectrometry of Protein Complexes; Paul Spier1; Lindsay
Morrison2; Jeremy Wolff1; Christopher Thompson1; Vicki
Wysocki2; 1Bruker Daltonics, Billerica, MA; 2Ohio State
University, Columbus, OH
WP 417 Native Salt-Bridge Structure of Proteins by ETD
followed by CID; Zhe Zhang; Shaynah Browne; Vachet
Richard; University of Massachusetts, Amherst, MA
WP 418 Direct Coupling of Ion Exchange Chromatography and
Native Electrospray Mass Spectrometry for Routine
Analysis of Biological Complexes at Endogenous
Levels; Zachary Quinkert; Paul D. B. Olinares; Júlio C.
Padovan; Brian T. Chait; The Rockefeller University, New
York, NY

61ST ASMS CONFERENCE ON MASS SPECTROMETRY

WEDNESDAY POSTERS

WP 419 Molecular Weight Analysis of Macromolecular
Complexes by LiquiScan-ES; Elisbeth Loecken; Sherrie
Elzey; TSI, Inc., Shoreview, MN
WP 420 Native Mass Spectrometry and Global H/D Exchange of
Whole Proteins and Noncovalent Protein Complexes by
Surface Acoustic Wave Nebulization; Lucas Monkkonen;
J. Scott Edgar; Scott Heron; Eri Nakatani; Carlos E.
Catalano; David R. Goodlett; University of Washington,
Seattle, WA
WP 421 Role of Histidine Rich Epitopes in the Formation of
Non-Covalent Complexes; Aurelie Roux; Ludovic M.
Muller; Luciana Tovo Rodrigues; Amina S. Woods; NIH/
NIDA IRP, Baltimore, MD
Antibody & Antibody Drug Conjugates, 422 – 446
WP 422 Native Orbitrap Mass Spectrometry Yields Higher
Resolution and Potential for Relative Quantitation
of Complex Antibody Mixtures; Natalie Thompson 1;
Sara Rosati1; Linda J.A. Hendriks2; John de Kruif2; Mark
Throsby2; Albert J.R. Heck1; 1Utrecht University, Utrecht,
Netherlands; 2Merus, Utrecht, Netherlands
WP 423 Using MALDI-TOF MS to Screen for Monoclonal
Gammopathies in Serum and Urine; David Barnidge1; Tim
Griffin2; Tom Krick2; David Murray1; 1Mayo Clinic, Rochester,
MN; 2University of Minnesota, St. Paul, MN
WP 424 Investigating Structure/ Function Relationships of
Immunoglobulin Molecules Using Shape Selective
Mass Spectrometry; Matthew Edgeworth; James Scrivens;
University of Warwick, Coventry, UK
WP 425 Rapid Disulfide Bond Analysis of a Recombinant
Monoclonal IgG Using Electron Transfer Dissociation;
Daniel Clark; Eden Go; Heather Desaire; University of
Kansas, Lawrence, KS
WP 426 Development of a Peptide Affinity Column for anti-TNFalpha Monoclonal Antibodies; Noritaka Hashii; Ryosuke
Kuribayashi; Akira Harazono; Shiori Nakazawa; Nana
Kawasaki; National Institute of Health Sciences, Tokyo,
Japan
WP 427 Improved Characterization of the Serum Antibody
Response through Selective Enrichment and 193 nm
Photodissociation of IgG Heavy Chain CDR3 Peptides;
Victoria Cotham; Yariv Wine; George Georgiou; Jennifer
Brodbelt; University of Texas, Austin, TX
WP 428 Simultaneous Peptide Mapping, Posttranslational
Modifications and Major N-glycosylation
Characterization of Trastuzumab by Sheathless CEESI-MS/MS - Comparison to nanoLC-MS/MS; Rabah
Gahoual1; Alicia Burr1; Jean-Marc Busnel2; Lauriane
Kuhn3; Philippe Hammann3; Alain Beck4; Yannis Francois1;
Emmanuelle Leize-Wagner1; 1LSMIS, University of
Strasbourg, Strasbourg, France; 2Beckman Coulter Inc.,
Brea, CA; 3IBMC, University of Strasbourg, Strasbourg,
France; 4Centre d’immunologie Pierre Fabre, Saint-Julienen-Genevois, France
WP 429 CE-UV/MALDI-MS: A New Platform for Proteomic and
Intact Protein Characterization; Michael Biacchi1; Anja
Resemann2; Pierre-Olivier Schmit3; Alain Beck4; Yannis
Francois1; Emmanuelle Leize1; 1LSMIS, University of
Strasbourg, Strasbourg, France; 2Bruker Daltonik GmbH,
Bremen, Germany; 3Bruker Daltonique S.A, Wissembourg,
France; 4Centre d’immunologie Pierre Fabre, Saint-Julienen-Genevois, France
WP 430 Complementary Glycan Quantitation Strategies Based
on High Sensitivity NanoLC/MS; Mellisa Ly; Gregory
Staples; Hongfeng Yin; Kevin Killeen; Agilent Labs, Agilent
Technologies, Santa Clara, CA

WP 431 Identification of Pyroglutamate and O-linked
Glycosylation on Anti-IL17A Peptide Anti-IL22 Antibody
Bispecific Genetic Fusion; Eric Sousa1; Xiaotian Zhong1;
Elizabeth Kieras1; Aaron D’Antona1; J. Christian Baber1;
Joel Desharnais2; Lauren Wood2; Deborah Luxenberg1;
Mark Stahl1; Ronald Kriz1; Laura Lin1; Will Somers1; Lori
Fitz1; Jill Wright1; Tao He1; 1Pfizer, Cambridge, MA; 2CovX,
San Diego, CA
WP 432 Characterization of Hydrophobic Interaction
Chromatography (HIC) Fractionated Antibody
Bioconjugates; Michael Bacica; Ryan Preston; Robert
Murphy; Pfizer/CovX, San Diego, CA
WP 433 Quantitative Profiling of NHS Drug Conjugation Sites
on IgG1 Based Antibody Drug Conjugates using Data
Independent Analysis; Dan Rock1; Kelli Jonakin2; Eric
Johansen2; 1Amgen Inc, Seattle, WA; 2ABSCIEX, Foster
City, CA
WP 434 Optimizing the Enzymatic Subunit Generation with
IdeS for High Throughput Structure Verification
of Therapeutic Antibodies by Middle-Down Mass
Spectrometry; Fredrik Olsson1; Linda Andersson1; Matthew
Willetts2; Wolfgang Jabs3; Anja Resemann3; Waltraud
Evers3; Carsten Baessmann3; Detlev Suckau3; 1Genovis AB,
Lund, Sweden; 2Bruker Daltonics Inc, Billerica, MA; 3Bruker
Daltonik GmbH, Bremen, Germany
WP 435 Combination of Online Fractionation and ETD-UHR
QTOF to Enhance Middle-Down Monoclonal Antibodies
Characterization; Guillaume Tremintin1; Wolfgang Jabs2;
1
Bruker Daltonics, Fremont, CA; 2Bruker Daltonik, Bremen,
Germany
WP 436 Rapid Analysis of Intact Antibody-drug
Conjugates(ADCs) by UPLC Q-TOF MS; Wei Jia1;
ChuanFei Yu2; Kai Gao2; 1Waters ShangHai, Beijing, China;
2
ChinaNational institutes for food and drug control, Beijing,
China
WP 437 Paired Acquisition of Spectra for Monoclonal Antibody
Sequencing; Natalie Castellana; Digital Proteomics, LLC.,
San Diego, CA
WP 438 Analytical Solutions for Pharmacokinetic Analysis of
Antibody Drug Conjugates; Kan Zhu; Roxana Garcia
Caro; Karen Wang; Novartis, Cambridge, MA
WP 439 Advanced LC-MS Methods for Characterization
and Heterodimer Purity Assessment of Bispecific
Antibodies; Jeremy Woods1; Thomas Spreter von
Kreudenstein2; Gordon Ng2; Surjit B. Dixit2; Hongwei Xie1;
1
KBI Biopharam, Durham, North Carolina; 2Zymeworks, Inc.,
Vancouver, BC, Canada
WP 440 FC antibody Fragments Analysis Using MALDI ISD;
Sega Ndiaye1, 2; Angélique Boedec1; François Gray2;
Florence Lhospice1; Claude Villard2; Rima Ait-Belkacem2;
Christian Belmant1; Daniel Lafitte2; 1Innate Pharma,
Marseille, Fr; 2Aix-Marseille Université, Marseille, France
WP 441 Direct Coupling of Protein-A HPLC with Mass
Spectrometry: A Useful Approach to Analyze
Monoclonal IgG Antibody-Maytansinoid Conjugates
from Complex Matrices; Megan Ellis; Lintao Wang;
Alexandru C. Lazar; ImmunoGen, Inc., Waltham, MA
WP 442 Intact Mass Analysis of Monoclonal Antibody (MAb)
Charge Variants Separated Using Linear pH Gradient;
Shanhua Lin; Zhiqi Hao; Wim Decrop; Julia Baek; Udayanath
Aich; Patrick Bennett; Srinivasa Rao; Yury Agroskin; Chris
Pohl; Thermo Fisher Scientific, Sunnyvale, CA
WP 443 Rapid Peptide Mapping via Automated Integration of
On-line Digestion, Separation and Mass Spectrometry
for the Analysis of Therapeutic Proteins; Esther Lewis;
Zhiqi Hao; Patrick Bennett; Thermo Fisher Scientific, San
Jose, CA

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WEDNESDAY
POSTERS

WP 444 Characterization of Monoclonal Antibody Glycoforms
Using a Novel Glycan Column Technology and BenchTop Orbitrap LC-MS/MS; Zhiqi Hao1; Udayanath Aich2;
Julian Saba1; Rosa Viner 1; Xiaodong Liu2; Srinivasa Rao2;
Chris Pohl2; Andreas Huhmer1; Patrick Bennett1; 1Thermo
Fisher Scientific, San Jose, CA; 2ThermoFisher Scientific,
Sunnyvale, CA
WP 445 Characterization of Disulfide-linked and Glycosylated
Intact Monoclonal Antibodies by Ultrahigh Resolution
ETD with LC-MS Topdown Approach; Shiaw-Lin Wu1;
Zhiqi Hao2; David Horn2; Andreas FR Hühmer2; Barry L.
Karger1; 1Northeastern University, Boston, MA; 2Thermo
Fisher Scientific, San Jose, CA
WP 446 IgG1 Thioether Bond Formation in vivo; Qingchun
Zhang; Matthew R. Schenauer; John D. McCarter; Amgen,
Thousand Oaks, CA
Analysis of Biosimilars, 447 – 452
WP 447

WP 448

WP 449

WP 450

WP 451

WP 452

Applying Multiple Orthogonal Analytical Methodologies
for Comprehensive Biosimilar Comparability
Assessment; Henry Shion; Vera Ivleva; Ying Qing Yu; Tom
Wheat; Weibin Chen; Waters Corp., Milford, MA
N-linked Glycan Profile Comparison between the
Innovator and a Biosimilar Etanercept; Ying-Qing Yu;
Waters Corporation, Milford, MA
Determination of O-Glycosylation Site and O-glycan
Profile at the Site on Etanercept Using UPLC-MS/MS;
Jung-Keun Suh1; Hyong-Ha Kim2; 1Korean German Institute
of Technology, Seoul, South Korea; 2Korea Research
Institute of Standards and Science, Seoul, Korea
Qualitative and Quantitative Characterization of
Therapeutic Antibody Using High Speed and High
Resolution Mass Spectrometry; Byung-Hee Shin1; Eric
Johansen2; Justin Lim3; Jason Neo3; 1AB Sciex Korea Ltd,
Seoul, South Korea; 2AB Sciex, Foster City, CA; 3AB Sciex
Ltd., Singapore
Utilizing a Novel Compact Mass Spectrometer (CMS) in
the Real-Time Monitoring of a Continues Solution Phase
Peptide Synthesis; Daniel Eikel1; Shahnaz Ghassemi2;
Simon Prosser1; 1Advion Inc., Ithaca, NY; 2Synpure LLC,
Charlottesville, VA
Optimization of Qualitative and Quantitative Follicle
Stimulating Hormone Analyses by High Performance
Mass Spectrometry; Dipankar Malakar; Annu Uppal; Faraz
Rashid; Manoj Pillai; AB Sciex, India, Gurgaon, India
Biomarkers: Discovery, 453 – 475

WP 453 Utilizing Mass Spectrometry-Based Profiling System
to Identify Cellular Response Proteins Induced by
Silk Fibroin Surface-Modified Biomaterials; Ming-Hui
Yang1; Tze-Wen Chung1; Yu-Chang Tyan 2; 1National
Yunlin University of Science & Technology, Yunlin, Taiwan;
2
Kaohsiung Medical University, Kaohsiung, Taiwan
WP 454 Aptamer-Based Tool for Lung Cancer Biomarker
Discovery; Yury Glazyrin1; Olga Kolovskaya1; Galina
Zamay1; Anna Zamay1; Evgeny Erkaev1; Alexey Krat2;
Maxim Berezovski3; Yaroslav Lyutvinskiy4; Roman Zubarev4;
Tatyana Zamay1; 1Krasnoyarsk State Medical University,
Krasnoyarsk, Russia; 2Krasnoyarsk Regional Clinical
Oncological Center, Krasnoyarsk, Russia; 3University of
Ottawa, Ottawa, Canada; 4Karolinska Institutet, Stockholm,
Sweden
WP 455 Comparison of Pancreas-Specific Proteins Using
an Accurate Mass and Time Tag Approach in Hu-14
Depleted and Un-Depleted Pancreatic Juice; Jana
Rocker1; Lee Thompson2; Dean Billheimer3; Lewis Pannell1;
1
Mitchell Cancer Institute, Mobile, AL; 2Mobile Infirmary
Medical Center, Mobile, AL; 3University of Arizona, Tucson, AZ

PAGE 138					

WP 456 Development of Methods for Information-Driven MS/MS
(ID-MS/MS) for Increased Identification Rates in BottomUp Proteomics of Human Blood Serum; Peter Brechlin1;
Stuart Pengelley1; Pierre-Olivier Schmit2; Ow Sawyen3; Dirk
Wunderlich1; 1Bruker Daltonik GmbH, Bremen, Germany;
2
Bruker Daltonique S.A., Wissembourg, France; 3Bruker
Daltonics Inc, Beijing, China
WP 457 Detection of Cellular Response to an in vitro Challenge
with Bacterial Gram-Negative Lipopolysaccharides
(LPS) in Peripheral Blood Mononuclear Cells (PBMCs);
David A Sarracino 1; Jennifer Sutton1; Maryann Vogelsang1;
Bryan Krastins1; Gregory Byram1; Amol Prakash1; Gouri
Vadali1; Vineet Gupta2; Mary F Lopez1; 1Thermo Fisher
Scientific, Cambridge, MA; 2Rush University Medical Center,
Chicago, Il
WP 458 Proteomics Analysis of Leishmania exosomes; Brajesh
Singh; Jason Weirather; Patrick Kelly; Yalan Li; R. Marshall
Pope; Mary Wilson; University of Iowa, Iowa City, IA
WP 459 Quantitative and Facile Analysis of the ATP-binding
Proteome of Mycobacterium tuberculosis: Disease
State Biomarkers and Novel Therapeutic Targets; Lisa
Wolfe1, 2; Jessica Prenni2; Karen Dobos1; 1Colorado State
University, Fort Collins, CO; 2Proteomics and Metabolomics
Facility, Fort Collins, CO
WP 460 LC-MS Based Detection and Quantification of N-glycans
in Human Serum Samples; Tsung-Heng Tsai1; Minkun
Wang1; Cristina Di Poto1; Yi Zhao1; Yunli Hu2; Shiyue Zhou2;
Yehia Mechref2; Habtom Ressom1; 1Georgetown University,
Washington, DC; 2Texas Tech University, Lubbock, TX
WP 461 Quantification of the Airway Mucin-Interactome
in the Beta ENaC-transgenic Mouse Using Mass
Spectrometry; Rui Cao; Alessandra Livraghi-Butrico;
Tiffany Wang; Wanda O’Neal; Mehmet Kesimer; University
of North Carolina, Chapel Hill, NC
WP 462 Comparative Analysis of the Proteomic Changes of
Amniotic Fluid in Different Gestational Age for Lung
Development; Jingxin Wang1; Shigetoshi Yokoyama2;
Robert Cunningham3; Xin Sun2; Lingjun Li3; 1Neuroscience
Training Program, UW, Madison, WI; 2Laboratory of
Genetics, UW, Madison, WI; 3School of Pharmacy, UW,
Madison, WI
WP 463 Probing Phosphatidylcholine Metabolites and
Diagnostic Biomarkers for Early Stage Lung Cancer
Using nanoMate-FTICR MS; Yumei Guo; Zhili Li; IBMS,
CAMS&PUMC, Beijing, China
WP 464 Quantitative Proteomics in Non-Case versus Control
Studies; Lauren Devine1; Ingo Ruczinski2; Keith West2;
Kerry Schulze2; Robert Cole1; 1Johns Hopkins Mass Spec
and Proteomics Facility, Baltimore, MD; 2Johns Hopkins
School of Public Health, Baltimore, md
WP 465 An Adductomic Approach to Measure and identify
Hemoglobin Adducts of Possible Genotoxic
Compounds Using LC-MS; Henrik Carlsson; Hans von
Stedingk; Ulrika Nilsson; Margareta Törnqvist; Stockholm
University, Stockholm, Sweden
WP 466 Altered Expression of Sialylated Glycoproteins in
Ovarian Cancer Using a Lectin Array and LC-MS/MS;
Jing Wu1; Xiaolei Xie2; Song Nie1; Ronald Buckanovich1;
David Lubman1; 1University of Michigan, Ann Arbor, MI;
2
Caprion Proteomics US LLC, Menlo Park, CA
WP 467 Potential Lipid Biomarker Identification in
Hepatocellular Carcinoma; Guangxiang Wu1; Yiyun
(Sherry) Wang2; Nicholas J. Skill3; Mary A. Maluccio3;
Patrick L. Love2; 1Biomarker Center of Excellence, Covance,
Greenfield, IN; 2In Vivo Pharmacology-Receptor Occupancy,
Covance, Greenfield, IN; 3Indiana University School of
Medicine, Indianapolis, IN

61ST ASMS CONFERENCE ON MASS SPECTROMETRY

WEDNESDAY POSTERS

WP 468 Discovery of Glyco-Biomarkers of Complications in
Diabetes; Di Wu1; Helen Colhoun2; Michael Ferguson1;
1
College of Life Sciences, University of Dundee, Dundee,
UK; 2Medical Research Institute, University of Dundee,
Dundee, UK
WP 469 Mass-Spectrometry Based Analysis of Human Blood
Sera Peptidome for a Search of Socially Significant
Disease Biomarkers; Georgy Arapidi1, 2; Rustam
Ziganshin1; Sergey Kovalchuk1; Igor Azarkin1; Olga
Ivanova1; Nikolay Anikanov1; Dmitry Kamaev1; Vadim
Govorun1; Vadim Ivanov1; 1Institute of Bioorganic Chemistry,
RAS, Moscow, Russian Federation; 2Moscow Institute of
Physics and Technology, Moscow, Russian Federation
WP 470 A Novel Quantification Model for Discovering
Glycopeptide Biomarkers; Anoop Mayampurath 1;
Ehwang Song2; Chuan-yih Yu1; Yehia Mechref2; Haixu
Tang1; 1Indiana University, Bloomington, IN; 2Texas Tech
University, Lubbock, TX
WP 471 Biomarker Discovery for Radiation Induced Tissue
Damage Via Un-Targeted Mass Spectrometry Based
Metabolomics; Jace W. Jones; Alexander Bennett; Ann M.
Farese; Thomas J. MacVittie; Maureen A. Kane; University
of Maryland, Baltimore, MD
WP 472 Metformin Decreases Glyco-Oxidation Markers: A Study
Utilizing Multiple Reaction Monitoring; Owen Kinsky1,
6
; Michael Kimzey1, 6; Serena Allred2, 6; Tarun Anumol3, 6;
Hussein Yassine4, 6; Craig Stump4, 6; George Tsaprailis1,
6
; Shane Snyder3, 6; Dean Billheimer5, 6; Terrence Monks1,
6
; Serrine Lau1, 6; 1SWEHSC, Dept. of Pharm/Tox, College
of Pharmacy, Tucson, AZ; 2Division of Epidemiology
and Biostatistics, Tucson, AZ; 3Dept. of Chemical &
Environmental Engineering, Tucson, AZ; 4College of
Medicine, Tucson, AZ; 5AZ Stat. Cons. Lab, Dept. of Ag. and
Biosys. Eng., Tucson, AZ; 6University of Arizona, Tucson,
AZ
WP 473 MALDI TOF/TOF Determination of Serum Plasminogen
Sialylation Profile from Patients with Gastric
Precancerous Lesions; Catarina Gomes1; Andreia
Almeida2; Alexandre Ferreira2; Celso Reis1, 3; Hugo Osorio1,
3 1
; IPATIMUP, Porto, Portugal; 2Department of Chemistry,
University of Aveiro, Aveiro, Portugal; 3Faculty of Medicine,
University of Porto, Porto, Portugal
WP 474 Integrating Targeted Strategies for Characterization and
Quantification Using Orbitrap Technology and Novel
Software for Targeted Glycoprotein/Peptide Studies;
Sucharita Dutta1; Julian Saba2; Scott Peterman2; Sergei
Snovida3; Lifang Yang1; Julius Nyalwidhe1; Oliver Semmes1;
1
Leroy T. Canoles Cancer Center - EVMS, Norfolk, VA;
2
Thermo Fisher Scientific, San Jose, CA; 3Thermo Fisher
Scientific -Rockford, Rockford, IL
WP 475 Biomarker Screening for Drug-Induced Nephrotoxicity
in Rats Using UPLC-MSE; Liuxi Chen1; Brad Williams2;
Jonathan Phillips1; Scott Geromanos2; Vladimir Papov1;
1
Boehringer Ingelheim Pharmaceuticals, Inc, Ridgefield, CT;
2
Waters Corporation, Milford, MA
Biomarker Quantitation: New Methods, 476 – 489
WP 476 Application of DiLeu Isobaric Tandem-Mass Tags to
Quantitative Proteomic Analyses of Cerebrospinal Fluid
from Alzheimer’s Disease Patients; Dustin Frost; Jingxin
Wang; Robert Cunningham; Cynthia Carlsson; Lingjun Li;
University of Wisconsin, Madison, WI
WP 477 Extraction and Quantitation of Biomarkers from Human
Plasma in the Low Nanogram Range with a Rapid and
Economical Method; Jun Wang1; Lingjun Li2; Zong-Ping
Zhang1; 1PPD, Middleton, U.S; 2University of Wisconsin,
Madison, WI

WP 478 Utilizing MFLC/MS/MS for Large Molecule Quantitative
Bioanalysis; Casey Johnson; Jennifer Zimmer; Chad
Christianson; Shane Needham; Alturas Analytics, Moscow,
ID
WP 479 Improved Throughput and Reproducibility for Targeted
Protein Quantification Using a New High Performance
Triple Quadrupole Mass Spectrometer; Reiko Kiyonami;
Mary Blackburn; Andreas Hühmer; ThermoFisher Scientific,
San Jose, CA
WP 480 Ultrathroughput Multiple Reaction Monitoring Mass
Spectrometry for Protein Biomarker Validation in
Nondepleted Serum; Mary Joan Castillo; Adam Jay
McShane; Xudong Yao; University of Connecticut, Storrs,
CT
WP 481 Defining Expectations for iTRAQ Analysis of Urinary
Proteins by a Common, Cost-Conscious Approach;
Yun Jiang1; Matthew Wroblewski1; Yan Zhang2; Gary
Nelsestuen1; 1University of Minnesota, Minneapolis, MN;
2
University of Rochester, Rochester, NY
WP 482 TMTcalibrator – A Novel Method Delivering Low ng/ml
Sensitivity for Targeted MS Assays in Biological Fluids;
Ian Pike1; Emma Lahert1; Claire Russell1; Christopher
Lößner2; Stephan Jung2; Sasa Koncarevic2; Malcolm Ward1;
1
Proteome Sciences plc, London, UK; 2Proteome Sciences
R&D GmbH & Co. KG, Frankfurt, Germany
WP 483 Effective Coupling of CITP/CZE with nanoESI-MS Using
Advanced Interface Technologies for High Sensitivity
Sample Quantification; Keqi Tang1; Chengcheng Wang2;
Cheng S. Lee2; Richard D. Smith1; 1Pacific NW National
Laboratory, Richland, WA; 2University of Maryland, College
Park, MD
WP 484 Targeted Mass Spectrometric Approach Coupled with
Long Gradient Separation Enables Highly Sensitive,
Large Scale Protein Quantification in a Single Analysis;
Tujin Shi1; Thomas L. Fillmore2; Rui Zhao2; Athena A.
Schepmoes1; Carrie D. Nicora1; Yuqian Gao1; Ronald J.
Moore1; Tao Liu1; Karin D. Rodland1; Keqi Tang1; Richard D.
Smith1; David G. Camp1; Wei-Jun Qian1; 1PNNL, Richland,
WA; 2Environmental Molecular Sciences Laboratory, PNNL,
Richland, WA
WP 485 Metal-tag Labeling Coupled with Multiple Reaction
Monitoring-Mass Spectrometry for Absolute
Quantitation of Proteins; Yangjun Zhang; Xueying Wang;
Xin Wang; Hongjun Lin; Xiaohong Qian; Beijing Proteome
Research Ctr, Beijing, China
WP 486 Evaluating the Ruggedness of Nanospray on a Curtain
Gas-Triple Quadrupole MS Equipped with Emitter
Rinsing; Amanda Berg; Helena Svobodova; Ben Ngo; Gary
Valaskovic; New Objective, Inc., Woburn, MA
WP 487 Automation of Immunoprecipitation via Magnetic Beads
on the Perkin Elmer Janus Platform for Biomarker
Analyses; Richard Wong; Baomin Xin; Timothy Olah;
Bristol-Myers Squibb, Pennington, NJ
WP 488 Targeted Protein Quantification for Human Plasma
Samples by MRM and MRM-HR; Xiaomin Song1; Thiri
Zaw1; Ardeshir Amirkhani1; Chris Hodgkins2; Mark Molloy1;
1
APAF, Macquarie University, Sydney, Australia; 2ABSCIEX,
Sydney, Australia
WP 489 A High-Throughput and Reproducible Workflow for
MRM Analysis of Biological Samples; Qin Fu*(equal
contribution) 1; Michael Kowalski* (equal contribution) 2;
Weihua Ji1; Jie Zhu1; Graham Threadgill3; Christie Hunter4;
Jennifer Van Eyk1; 1Johns Hopkins University, Baltimore,
MD; 2Beckman Coulter Life Sciences, Indianapolis, IN;
3
Beckman Coulter, Inc., Fullerton, CA; 4AB Sciex, Foster
City, CA

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WEDNESDAY
POSTERS

Proteins: Complexes and Aggregation, 490 – 514
WP 490 Development of an Online Size Exclusion
Chromatography-Mass Spectrometry Method for
Characterization of Highly Heterogeneous Protein
Samples; Khaja Muneeruddin; Rinat Abzalimov; Igor A.
Kaltashov; University of Massachusetts, Amherst, MA
WP 491 Online- Bioaffinity- Mass Spectrometry for “Top-Down”
Structure and Affinity Determination of α-Synuclein
Aggregation; Michael Przybylski1; Stefan Slamnoiu1;
Mihaela Stumbaum1, 2; Camelia Vlad1, 2; Kathrin Lindner1;
Christiaan Karreman1; Marcel Leist1; Bastian Hengerer3;
1
Universitat Konstanz, Konstanz, Germany; 2SAWInstruments GmbH, Bonn, Germany; 3Boehringer Ingelheim
GmbH & Co KG, ZNS Research, Biberach, Germany
WP 492 Phosphorylation of the Sae2 Endonuclease Regulates
Its Solubility and Activity in DNA Repair; Qiong Fu; Chiafang Lee; Julia Chow; Maria D. Person; Tanya T. Paull; The
University of Texas, Austin, TX
WP 493 Mapping synphilin-1 Binary Interactions Using
Isotopically Tagged Cross-Linking and Mass
Spectrometry; Xiaobin Xu1; Han Hu2; Anatoli B. Meriin2;
Nava Zaarur2; Nancy Leymarie2; Yi Pu1; Mark E. McComb2;
Michael Y. Sherman2; Catherine E. Costello1, 2; 1Boston
University, Boston, MA; 2Boston University School of
Medicine, Boston, MA
WP 494 Mapping Protein-DNA Interactions Using UV Crosslinking and Mass Spectrometry; Fiona Flett1; David
Clarke2; Pat Langridge Smith2; Logan Mackay2; Heidrun
Interthal1; 1School of Biology, University of Edinburgh,
Edinburgh, UK; 2School of Chemistry, University of
Edinburgh, Edinburgh, UK
WP 495 Protein Structures and Protein-Protein Interactions:
Identifying Links; James Bruce; Juan Chavez; Chunxiang
Zheng; Chad Weisbrod; Arti Navare; Xia Wu; Jimmy Eng;
Sayaka Shibata; Shaday Michan; Richard Harkewicz;
University of Washington, Seattle, WA
WP 496 A Combination of CHiP Seq and Mass Spectrometry
Methods Provides Complementary Proteomic and
Genomic Data; Clive S. D’Santos1; Hisham Mohammed2;
Christopher Taylor1; Aurelian Serandour2; Gordon D.
Brown2; H. Raza Ali2; Kelly Holmes2; Jessica Robinson2;
Amel Saadi2; John Stingl2, 3; Carlos Caldas2, 3; Jason S.
Carroll2, 3; 1Proteomic Core Facility, CRUK Cambridge
Institute, Cambridge, CB20RE; 2CRUK Cambridge Institute,
Cambridge, UK; 3Department of Oncology, University of
Cambridge, Cambridge, UK
WP 497 Protein Cross-Linking of Multi-Protein Complex of
S100A8 and S100A9 with TLR4/MD2: Considerations
Regarding Chemistry and Efficiency; Alena Dreiling;
Thomas Vogl; Johannes Roth; Simone Koenig; University of
Muenster, Muenster, Germany
WP 498 Identification of Stress-Dependent Interactors of the
MAP Kinase Sty1 in Schizosaccharomyces pombe;
Guadalupe Espadas1; Esther Paulo2; Francesco M.
Mancuso1; Elena Hidalgo2; Eduard Sabidó1; 1Proteomics
Unit CRG/UPF, Barcelona, Spain; 2Universitat Pompeu
Fabra, Barcelona, Spain
WP 499 Topology of the Anaphase Promoting
Complex/Cyclosome Studied by CBDPS
(cyanurbiotindipropionylsuccinimide) Crosslinking;
Nicole Sessler1; Taka-Aki Ichu2; Evgeniy Petrotchenko1;
Christoph Borchers1, 3; 1University of Victoria-Genome BC
Proteomics Centre, Victoria, Canada; 2University of Victoria,
Victoria, Canada; 3Dept of Biochemistry and Microbiology, U
Victoria, Victoria, Canada

PAGE 140					

WP 500 Determination of Outer Dynein Arm Protein Complex
Topology using Chemical Crosslinking and LC/MS/
MS Analysis; Kevin Blackburn 1; Andrew Argo1; Lawrence
Ostrowski2; Michael B. Goshe1; 1North Carolina State
University, Raleigh, NC; 2University of North Carolina,
Chapel Hill, NC
WP 501 Chaperones Identified from Affinity Purification-MS/MS
Facilitate Epilepsy-Associated Mutant GABAA Receptor
Folding in the Endoplasmic Reticulum; Yajuan (Megan)
Wang; Xiao-Jing Di; Mark R. Chance; Ting-Wei Mu; Case
Western Reserve University, Cleveland, OH
WP 502 Fluorescence Complementation Affinity Proteomics to
Study Kinase Substrate Interactions; Lingfei Zeng; ChihChao Hsu; Chang-Deng Hu; Andy Tao; Purdue University,
West Lafayette, IN
WP 503 Applications of the Fc-III Tagged Protein Expression
System for Studying Protein Complexes; Shan Feng;
Gulishana Adelijiang; Yiyi Gong; Lixiao Gu; Haiteng Deng;
Tsinghua University, Beijing, China
WP 504 Magic Lysis Buffer Improves the Efficiency of
Immunoprecipitation-LC/MS/MS (IP-MS) with Less NonSpecific Interactions and Stronger Retention of Binding
Protein Partners; Susanne Breitkopf1; Min Yuan1; John
Neveu3; John M Asara1, 2; 1Beth Israel Deaconess Medical
Center, Boston, MA; 2Harvard Medical School, Boston, MA;
3
ESI Source Solutions, Woburn, MA
WP 505 iTRAQ Stable Isotope Labeling and Multiple
Immunoaffinity Matrices for Enhanced Mass
Spectrometric Identification of Protein Complex
Constituents; Sricharan Bandhakavi1; Michael Early1;
Jonathan Kohn1; Ebbing de Jong2; Timothy Griffin2; 1Bio-Rad
Laboratories, Hercules, CA; 2University of Minnesota, MN
WP 506 ARL13B, PDE6D, and CEP164 Form a Functional
Network for INPP5E Ciliary Targeting; Melissa Humbert;
R. Marshall Pope; Yalan Li; Val C. Sheffield; Seongjin Seo;
University of Iowa, Iowa City, IA
WP 507 Single-step Affinity Isolation and Rapid Non-Denaturing
Elution of Endogenous Protein Complexes with
Subsequent LC-MS Characterization; Paul Dominic B.
Olinares; Zachary T. Quinkert; Amelia D. Dunn; Julio C.
Padovan; Brian T. Chait; The Rockefeller University, New
York, NY
WP 508 An Improved MS Strategy for Probing Protein-Protein
Interaction and Its Application in the Study of Tumor
Cell Chemotaxis; Ruibing Chen; Yanping Wang; Ning
Zhang; Tianjin Medical University, Tianjin, China
WP 509 A High-Throughput, Mass-Spectrometry-Based Platform
for Rapid Profiling of Human Protein Interaction
Networks; Edward L. Huttlin1; Lily Ting1; Raphael Bruckner1;
Melanie Gygi1; Robert Obar1; Virginia Guarani-Pereira1;
Ramin Rad1; Deepak Kolippakkam1; Bo Zhai1; Stanley Tam1;
Fana Gebreab1; Myriam Boukhali1; Joao Paulo1; Timothy
Harris2; Spyros Artavanis-Tsakonas1; Mathew Sowa1; J.
Wade Harper1; Steven P. Gygi1; 1Harvard Medical School,
Boston, MA; 2Biogen, Cambridge, MA
WP 510 Defining DNA Sensing Mechanisms during Host Innate
Immunity and Viral Immunosuppression; Benjamin
Diner; Tuo Li; John Fuesler; Ileana M. Cristea; Princeton
University, Princeton, NJ
WP 511 Quantitation of Proteins in Ribosomes and Ribosome
Assembly Complexes by LC-MSE; Romel Dator;
Kirk Gaston; Patrick Limbach; University of Cincinnati,
Cincinnati, OH
WP 512 Evolution of the Protein Stoichiometry in the L12
Stalk of Bacterial and Organellar Ribosomes; Ingo
Wohlgemuth1; Iakov Davydov I. 2; Irena I. Artamonova3;

61ST ASMS CONFERENCE ON MASS SPECTROMETRY

WEDNESDAY POSTERS

Alexander G. Tonevitsky4; Marina V. Rodnina1; Henning
Urlaub1, 5; 1MPI for Biophysical Chemistry, Goettingen,
Germany; 2SRC Bioclinicum, Moscow, Russia; 3Russian
Academy of Science, Moscow, Russia; 4Lomonosov
Moscow State University, Moscow, Russia; 5University
Medical Center Göttingen, Göttingen, Germany
WP 513 Mass Spectrometric Binding Study on Novel Anticancer
Agents as Tubulin Depolymerizer; Sool Yeon Cho 1;
Benjamin S. Hoffman2; Amol Padgaonkar1; Stephen C.
Cosenza1; Venkat Palella3; Muralidhar R. Mallireddigari 3;
D.R.C. Venkata Subbaiah1; Revathi Patti3; M. V. Ramana
Reddy1; E. Premkumar Reddy1; John Roboz1; 1Ichan
School of Medicine at Mount Sinai, New York, NY; 2The
Fels Cancer Institute, Temple University, Philadelphia, PA;
3
Onconova Therapeutics, Inc., Newtown, PA
WP 514 Role of Lysine Residues in the Interaction of Blood
Coagulation Factor VIII with Its Clearance Receptor
Low-Density Lipoprotein Receptor-Related Protein;
Maartje Van Den Biggelaar1; Johan H Faber2; Marleen
Zuurveld1; Carmen van der Zwaan1; Jesper J Madsen2; Ole
H Olsen2; Henning R Stennicke2; Koen Mertens1; Alexander
B Meijer1; 1Sanquin Research, Amsterdam, Netherlands;
2
Novo Nordisk, Kopenhagen, Denmark
Proteins PTM I, 515 – 539
WP 515 A Suitability Study of Commonly-Used Isolation
Techniques for Microtubule Associated Protein Tau
by LC-MS; Robert Pelot1, 2; Jon Reed1; Gogce Crynen1;
Corbin Bachmeier 1; James Evans1; Laila Abdullah1; Fiona
Crawford1; 1Roskamp Institute, Bradenton, FL; 2The Open
University, Milton Keynes, UK
WP 516 Oxidative Post-Translational Modifications of
Amyloidogenic Light Chain Proteins from a Patient with
Amyloid Light Chain Amyloidosis; Yanyan Lu; Yan Jiang;
Tatiana Prokaeva; Yang Mao; Lawreen Connors; Catherine
Costello; Boston University, Boston, MA
WP 517 Analysis of PTM Crosstalk in Photosynthetic Model
Organisms Using a 2D Gel-Based Approach; Silas
Rodrigues; Leslie Hicks; Donald Danforth Plant Science
Center, Saint Louis, MO
WP 518 Analysis of Protein Isoform in HEK293T Using New
N-terminome Strategy; Jeonghun Yeom1, 2; Cheolju Lee1,
2 1
; Korea institute science and technology, Seoul, Korea;
2
University of of Science and Technology, Daejeon, Korea
WP 519 a-N-methylation of DDB2 and Its Function in Nucleotide
Excision Repair; Qian Cai; Yinsheng Wang; University of
California, Riverside, CA
WP 520 Identification of indole-3-acetic Acid Modified Proteins
of Arabidopsis; Peng Yu1; Jutta Ludwig-Müller2; Adrian
Hegeman1; Jerry Cohen1; 1University of Minnesota, Falcon
Heights, MN; 2TU-Dresden, Dresden, Germany
WP 521 Characterization of Triose Phosphate Isomerase in
Drosophila Presenilin Mutant; Jong Bok Seo1; Soo Young
Kim1; Young Ho Koh2; 1Korea Basic Science Institute, Seoul,
South Korea; 2Hallym University, Anyang, Republic of Korea
WP 522 Probing the Transmural Molecular Heterogeneity of
the Heart Using High-Resolution Top-Down Mass
Spectrometry; Zachery Gregorich; Wei Guo; Timothy
Hacker; Ying Ge; UW, Madison, WI
WP 523 Qualitative Examination of the Diversity of Protein
Post-Translational Modifications Present in Model
Prokaryotic and Eukaryotic Organisms; Ritin Sharma2;
Rachel Adams2; Paul Abraham2; Robert Hettich1; 1Oak
Ridge National Laboratory, Oak Ridge, TN; 2University of
Tennessee, Knoxville, TN

WP 524 Characterization of Extensive Post-translational
Modification of Endogenous Human p53; Caroline
DeHart1; Jasdave S. Chahal2; S. J. Flint1; David H.
Perlman3; 1Dept. of Molecular Biology, Princeton University,
Princeton, NJ; 2Whitehead Institute for Biomedical
Research, MIT, Cambridge, MA; 3Proteomics and Mass
Spec. Core, Princeton Univ., Princeton, NJ
WP 525 Discovering the Role of Post-translational Modifications
in Regulation of Protein Activities in Diabetes using an
in vivo SILAC approach; Soraya Hoelper; Hendrik Nolte;
Thomas Braun; Marcus Krüger; Max-Planck-Institute for
Heart and Lung Research, Bad Nauheim, Germany
WP 526 Comparative Analysis of RNA Polymerase II Reveals
Potential Evolutionary Conserved Posttranslational
Modified Sites Amongst Schizosacharomyces pombe
and Saccharomyces cerevisiae; Selene Swanson1;
Charles Banks1; Zhihui Wen1; Brad Groppe1; Laurence
Florens1; Michael Washburn1, 2; 1stowers institute for
medical research, Kansas City, mo; 2University of Kansas
Medical Center, Kansas City, KS
WP 527 Deep Characterization of Combinatorial PostTranslational Modifications in a Natural Microbial
Community; Zhou Li1, 2; Yingfeng Wang2; Nicholas Justice3;
Tae-Hyuk Ahn2; Robert Hettich1, 2; Jillian Banfield3; Chongle
Pan1, 2; 1University of Tennessee, Knoxville, TN; 2Oak
Ridge National Laboratory, Oak Ridge, TN; 3University of
California, Berkeley, CA
WP 528 Calorie Restriction and SIRT3 Trigger Global
Reprogramming of the Mitochondrial Protein
Acetylome; Kristin Dittenhafer-Reed1; Alex Hebert1; Wei
Yu1; Derek Bailey2; Ebru Selin Selen3; Joshua Carson3;
Melissa Boersma1; Michael Westphall5; David Pagliarini3;
Tomas Prolla7; Fariba Assadi-Porter3, 6; Sushmita Roy4;
Joshua Coon1, 5; John Denu1; 1Department of Biomolecular
Chemistry, Madison, WI; 2Department of Chemistry,
Madison, WI; 3Department of Biochemistry, Madison, WI;
4
Dept of Biostatistics and Medical Informatics, Madison,
WI; 5Genome Center of Wisconsin, Madison, WI; 6National
Magnetic Resonance Facility at Madison, Madison, WI;
7
Department of Genetics and Medical Genetics, Madison, WI
WP 529 Radical Acetylation: Possible Routes of Epigenetic
Modifications of Proteins; Atecla Nunciata Lopes
Alves1; Sheila Barreto Guterres1; Emanuel Carrilho2; Maria
Aparecida Juliano1; Etelvino Jose Henriques Bechara1;
Nilson Antonio Assunção1; 1Unifesp, Sao Paulo, Br;
2
Universidade de Sao Paulo, Sao Paulo, Br
WP 530 Comprehensive Profiling of Protein Lysine Acetylation
in Escherichia coli; Kai Zhang1; Shuzhen Zheng1; Jeong
Soo Yang2; Yingming Zhao2; Yue Chen2; Zhongyi Cheng2;
1
Nankai University, Tianjin, China; 2The University of
Chicago, Chicago, IL
WP 531 Quantitative Profiling of Lysine Acetylation in Mouse
Tissues by AcetylScan; Hongbo Gu1; Matthew Stokes1;
Ailan Guo1; Kimberly Lee1; Jianmin Ren1; Xiaoying Jia1;
Meghan Duncan2; Vipin Suri2; Jeffrey Silva1; 1Cell Signaling
Technology, Danvers, MA; 2Sirtris, A GSK Company,
Cambridge, MA
WP 532 Enhanced Ionization Efficiency in ESI by Dimethylation
of Amines Compared to Acetylation of Amines;
Kyungcho Cho; JeongWon Kang; JiHye Hong; KwangPyo
Kim; Konkuk university, Seoul, Korea
WP 533 Distinct Lysine Methyation Profiles of Outer Membrane
Protein B in Virulent and Avirulent Rickettsiae Revealed
by LCMS; Guanghui Wang1; Amila Abeykoon2; ChienChung Chao3; Wei-Mei Ching3; David Yang2; Marjan
Gucek1; 1NHLBI, NIH, Bethesda, MD; 2Georgetown
University, Washington, DC; 3Naval Medical Research
Center, Silver Spring, MD

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WEDNESDAY
POSTERS

WP 534 A Dual-Enzyme and Dual-Activation Strategy for
Comprehensive and Accurate Characterization of
Protein Arginine-Methylation in Trypanosoma burcei
Mitochondrion; Jun Li; Chengjian Tu; Bo An; Jun Qu;
University at Buffalo, Buffalo, NY
WP 535 Proteome-Wide Screening of Lysine Succinylation in
Escherichia coli Reveals Its Broad Roles in Cellular
Metabolism; Minjia Tan1, 2; Yue Chen 1; Zhongyu Xie1; Zhike
Lu1; Yingming Zhao1; 1University of Chicago, Chicago, IL;
2
Shanghai Institute of Materia Medica, Shanghai, China
WP 536 The First Mammalian Succinylome Analysis Reveals
SIRT5-mediated Lysine Desuccinylation and Its Roles
in Diverse Cellular Pathways; Yue Chen 1; Chao Peng1;
Minjia Tan1, 2; Lunzhi Dai1; Zhongyu Xie1; Yingming Zhao1;
1
University of Chicago, Chicago, IL; 2Shanghai Institute of
Materia Medica, Shanghai, China
WP 537 Statistical Approaches to Infer Kinase Pathway
Activation from Mass Spectrometry-Based
Phosphoproteomics Data; Pedro R. Cutillas; Imperial
College London, London, UK
WP 538 In-gel Visualization and Identification of
Phosphoproteomes; Linna Wang; Weiguo Andy Tao;
Purdue University, West Lafayette, IN
WP 539 Low pH Differential Thiol Labeling Agents for Studying
Cellular Redox-based Regulation Using MS; Christopher
A Bonham; Aaron J Steevensz; Qiudi Geng; Panayiotis
O Vacratsis; Dept. of Chem. and Biochem., University of
Windsor, Windsor, ON, Canada

WP 547

WP 548

WP 549

WP 550

WP 551

Peptides: PTM Identifications, 540 – 574
WP 540 Highly Efficient Ionization of Phosphopeptides at
Low pH by Desorption Electrospray Ionization Mass
Spectrometry; Ning Pan1; Pengyuan Liu1; Weidong Cui2;
Bo Tang3; Jingmin Shi3; Hao Chen1; 1Ohio University,
Athens, OH; 2Washington University, St. Louis, MO;
3
Shandong Normal University, Jinan, China
WP 541 Electron-Transfer and Higher-Energy Collision
Dissociation, EThcD, Provides for Full Peptide
Sequence Coverage and Unambiguous Phosphosite
Localization; Christian Frese1; Dirk Nolting Nolting2; Jens
Griep-Raming2; Henk van den Toorn1; Houjiang Zhou1;
Thomas Taus3; Karl Mechtler3; Maarten Altelaar1; Albert J.
R. Heck1; Shabaz Mohammed1; 1Utrecht University, Utrecht,
Netherlands; 2Thermo Fisher Scientific, Bremen, Germany;
3
IMP - Research Institute of Molecular Pathology, Vienna,
Austria
WP 542 Extending the Phosphoproteomics Toolkit; Amanda
Patrick; Nicolas Polfer; University of Florida, Gainesville, FL
WP 543 Data Independent Analysis – A New Strategy for
Discovery of Phosphopeptides in Complex Proteome
Samples; Joerg Dojahn; Christian Baumann; AB SCIEX,
Darmstadt, Germany
WP 544 Investigation and Characterization of Potential
Dimetallic Tags for the Selective Recognition and
Protection of Phosphate Ester Groups in CAD
Activation; Simon Svane; Christine J. McKenzie; Frank
Kjeldsen; University of Southern Denmark, Odense M,
Denmark
WP 545 Coupling Immobilized Alkaline Phosphatase-based
Automated Diagonal Capillary Electrophoresis to
Tandem Mass Spectrometry for Phosphopeptide
Analysis; Si Mou; Liangliang Sun; Norman Dovichi;
University of Notre Dame, Notre Dame, IN
WP 546 Nucleus Phosphoproteome Reveals that EGF Regulates
Alternative Splicing through mTORC1 Pathway in MDAMB-468 Cells; Xianwei Chen1; Dan Guo1; Xiaomin Lou1;

PAGE 142					

WP 552

WP 553

WP 554

WP 555

WP 556

WP 557

Ju Zhang1; Jin Zi2; Jun Zhang1; Quanhui Wang1, 2; Haidan
Sun1; Zhaohui Wang1; Yuan Wang1; Weixin Guo1; Jiao Guo1;
Feng Xian1; Jia Zhang3; Yang Li3; Yusheng Dong3; Liang
Lin2; Siqi Liu1, 2; 1Beijing Institute of Genomics, CAS, Beijing,
China; 2BGI-Shenzhen, Shenzhen, China; 3Beijing Protein
Innovation, Beijing, China
Optimization of Lectin Enrichment of Glycopeptides
for Identification of Site-Specific Core-Fucosylation in
Human Serum; Zhijing Tan; University of Michiagan, Ann
Arbor, MI
Quantitative Site-Specific Glycosylation on HIV-1
Envelope Glycoprotein; Tsung-Ping Lin; Chein-Hung
Chen; Jennifer M. Lo; Che Alex Ma; Chung-Hsuan Chen;
Genomics Research Center, Academia Sinica, Taipei,
Taipei, Taiwan
Automatic Glycopeptide Sequencing by Y1 Ion (AGSY);
Chein-Hung Chen1; Hsin-Yu Hsieh1; Pang-Hung Hsu2;
Chung-Hsuan Chen1; 1Academia Sinica, Taipei, Taiwan;
2
National Taiwan Ocean University, Keelung, Taiwan
Identification of Prostate Specific Antigen Glycosylation
in Clinical Urine Samples by Mass Spectrometry; ChunJen Hsiao1, 2; Chein-Hung Chen1; Hsin-Yu Hsieh1; Wen
Horng Yang3; Tzong-Shin Tzai3; Chung Hsuan (Winston)
Chen1, 2; 1Academia Sinica, Taipei, Taiwan; 2National YangMing University, Taipei, Taiwan; 3National Cheng Kung
University Hospital, Tainan, Taiwan
Characterization of Sialylated Glycopeptides in
Caseinoglycomacropeptide by Tandem Mass
Spectrometry with Electron Transfer Dissociation
and High Energy Collision Dissociation; Haiying Li;
Finn Kirpekar; University of Southern Denmark, Odense,
Denmark
Modifications of Cysteine and MS Data Complexity;
Jens T Vanselow; Andreas Schlosser; Rudolf-VirchowZentrum, University Wuerzburg, Wuerzburg, Germany
Improvements in the Mass Spectrometric Detection
of S-Glutathionylated Peptides Using Multiple
Fragmentation Approaches; Susana Comte-Walters;
Jennifer Rutherford Bethard; Lauren Ball; Joachim Uys;
Medical Univ of S Carolina, Charleston, SC
Capturing Reversibly Oxidized Cysteines in the
Myocardium Using Thiol-Disulfide Exchange; Jana
Paulech; Nestor Solis; Max Puckeridge; Kiersten Liddy;
Melanie White; Stuart Cordwell; The University of Sydney,
Sydney, Australia
Defining Novel Redox-Regulated Targets of Growth
Factor Signaling Using Differential Alkylation,
Thiopropyl Sepharose Enrichment, and Label-Fee
Quantitative Proteomics; Jason Held; Tara Srinivasan;
Alexandria D’Souza; Birgit Schilling; Gary Scott; Christopher
Benz; Bradford Gibson; Buck Institute for Age Research,
Novato, CA
Characterization of a Post-translational Oxidative
Modification in a Fetal Hemoglobin (γ-V68M→D)
Associated with the Blue Baby Syndrome; Michael
Strader1; Wayne Hicks1; Ah-Lim Tsai2; Gang Wu2; John
Olson3; Mitchell Weiss4; Todd Mollan1; Abdu Alayash1; 1FDA/
CBER, Rockville, Md, MD; 2University of Texas-Houston
Medical School, Houston, TX; 3Rice University, Houston, TX;
4
The Children’s Hospital of Philadelphia, Philadelphia, PA
Stable Isotope Labeling with 18O to Examine Oxidative
Processes in Fetal Hemoglobin with a Met to Asp
Conversion; Wayne Hicks; Michael Strader; Todd Mollan;
Abdu Alayash; Food and Drug Administration, Gaithersburg,
MD

61ST ASMS CONFERENCE ON MASS SPECTROMETRY

WEDNESDAY POSTERS

WP 558 Mass Spectrometry Characterization of Acrolein Protein
Targets in the Liver: Focus On Site-Specific Analysis;
Yiying Zhu; Carthene Bazemore-Walker; Brown University,
Providence, RI
WP 559 A Simple Work Flow for Identification of Acylated
Proteins by LC MS/MS Using Sequentially Connected
C4 and C18 Columns; Wei Chen; Colin Gottlieb; Maurine
Linder; Robert Sherwood; Hong Jiang; Hening Lin; Sheng
Zhang; Cornell University, Ithaca, NY
WP 560 Mass Spectral Enhanced Detection of Ubls Using
SWATH Acquisition: MEDUSATM -Utilizing the Chemical
Derivatization Dependent Generation of Isopeptide
Diagnostic Ions; Navin Chicooree1, 2; John Griffiths1;
Yvonne Connolly 1; Thomas Knapman3; Christie Hunter4;
Duncan Smith1; 1Paterson Institute for Cancer Research,
Manchester, UK; 2School of Chemistry, University of
Manchester, Manchester, UK; 3AB SCIEX, Phoenix House,
Warrington, UK; 4AB SCIEX, Foster City, CA
WP 561 Identification of Ubiquitinated Synaptic Proteins and
Discovery of Lys29 Poly-Ubiquitin Function Using
Ubiquitin K29R Mutant Cells; Chan-Hyun Na; Drew
Jones; Yanling Yang; Xusheng Wang; Yanji Xu; Junmin
Peng; St Jude Children’s Research Hospital, Memphis, TN
WP 562 Large-scale Global Identification of Protein Lysine
Methylation in vivo; Xing-Jun Cao1; Anna M. Arnaudo1,
2
; Benjamin A. Garcia1; 1University of Pennsylvania,
Philadelphia, PA; 2Princeton University, Princeton, NJ
WP 563 Pitfalls in Identification of Lysine/Arginine Methylation
by MS - Influence of Sample Preparation; Bettina
Sarg1; Shadab Allipour Birgani2; Gerald Brosch2; Klaus
Faserl1; Leopold Kremser1; Herbert Lindner1; 1Div. of Clin.
Biochemistry, Biocenter Innsbruck, Innsbruck, Austria;
2
Division of Molecular Biology, Biocenter, Innsbruck, Austria
WP 564 Differentiation of Symmetric/Asymmetric Dimethylated
Arginine-containing Peptides Using MALDI Tandem
Mass Spectrometry; Matthew Openshaw1; Yuzo
Yamazaki2; Omar Belgacem1; Takeshi Kawamura3; 1Kratos
Analytical, Manchester, UK; 2Shimadzu Corporation, Kyoto,
Japan; 3University of Tokyo, Tokyo, Japan
WP 565 Identifying Citrullinated Peptides in Complex Mixtures:
Comparison of Label-Free and Chemical Modification
Methods; Manolo D. Plasencia1; Henry W. Rohrs2; Michael
L. Gross2; Emil R. Unanue1; 1Washington University School
of Medicine, St. Louis, MO; 2Washington University, St.
Louis, MO
WP 566 Direct Identification of Tyrosine Sulfation in Peptide
Anions using 193 nm Ultraviolet Photodissociation;
Michelle Robinson; Jennifer Brodbelt; University of Texas at
Austin, Austin, TX
WP 567 Side–Chain Losses in Electron Capture Dissociation
Improves the Identification of Pt(II)-modification Sites
on Peptides and Proteins; Huilin Li; Jonathon Snelling;
Mark Barrow; James Scrivens; Peter Sadler; Peter
O’Connor; University of Warwick, Coventry, UK
WP 568 S- to N-palmitoyl Migration during Proteomic Sample
Preparation; Yuhuan Ji; Catherine E. Costello; Cheng
Lin; Biochem Dept, Boston University School of Medicine,
Boston, MA
WP 569 Sensitive Peptide Identification with Multiple
Unexpected Modifications; June Snedecor; Nuno
Bandeira; UCSD, La Jolla, CA
WP 570 Posttranslational Modifications in Human Synaptic
Microdomains of Human Brain Tissue Discovered
Utilizing ABSciex Protein Pilot; Guy Uechi; Matthew
MacDonald; Mani Balasubramani; Robert Sweet; Nathan
Yates; University of Pittsburgh, Pittsburgh, PA

WP 571 Identification of Phosphorylation Sites in Chk2
Kinase; Henry W. Rohrs1; Ilan Geerlof-Vidavskiy2; Manolo
Plasencia1; Hao Zhang1; Alan Davis1; Petra ErdmannGilmore1; Anurag Agarwal1; Reid Townsend1; Helen PiwnicaWorms1; 1Washington University, St Louis, MO; 2FDA, St.
Louis, MO
WP 572 A large Synthetic Phosphopeptide Library for Mass
Spectrometry Based Proteomics; Harald Marx1; Simone
Lemeer1; Jan Schliep1; Lucrece Matheron2; Shabaz
Mohammed2; Juergen Cox3; Matthias Mann3; Albert Heck2;
Bernhard Kuster 1; 1Technical Universitiy Munich, Freising,
Germany; 2Utrecht University, Utrecht, NL; 3Max-Planck
Institute for Biochemistry, Munich, DE
WP 573 Elucidation of Direct Substrates of Abelson Tyrosine
Kinase in Cancer Cells Through Multiple Drug
Treatments and Sensitive Kinase Assay LinkedPhosphoproteomics; Justine Arrington; Liang Xue; W.
Andy Tao; Purdue University, West Lafayette, IN
WP 574 Titanium Dioxide Photocatalytic Oxidation of
Phosphopeptides for Simulation of in vivo Oxidation
Reactions; Miina Ruokolainen; Elisa Ollikainen; Tiina
Sikanen; Risto Kostiainen; Tapio Kotiaho; University of
Helsinki, Helsinki, Finland
Informatics: Peptide Identification/Characterization I,
575 – 596
WP 575 Improved Recovery of Information from Mass
Spectrometric Data When the Amount of Sample is
Severely Limited; Himanshu Grover1; Sarah Keegan1;
Jonathan Giuffrida1; Siyang Li2; Vladimir Brusic3; Shashi
Murthy2; Barry L. Karger2; Alexander R. Ivanov2; David
Fenyo1; 1New York University, New York, NY; 2Northeastern
University, Boston, MA; 3Dana-Farber Cancer Institute,
Boston, MA
WP 576 Untargeted Peptide Identification in SWATHTM-MS Using
Spectral Library Search; Jian Wang1; Monika Tuchoslka2;
Brett Larsen2; Stephen Tate3; Anne-Claude Gingras2;
Nuno Bandeira1; 1UCSD, La Jolla, CA; 2Samuel Lunenfeld
Research Institute at Mount Sinai, Toronto, Canada; 3ABSCIEX, Concord, Canada
WP 577 De novo Sequencing of Toxins from Predatory Sea
Snails; Yong Kil1; Wilfred Tang1; Chris Becker1; Marshall
Bern1; Julita Imperial2; Baldomera Olivera2; David Fenyo3;
Beatrix Ueberheide3; 1Protein Metrics Inc., San Carlos,
CA; 2University of Utah, Salt Lake City, UT; 3New York
University, New York, NY
WP 578 Comprehensive Characterization of Porcine and Bovine
Trypsin Digestion; Scott Walmsley1; Paul Rudnick2; Yuxue
Liang2; Qian Dong2; Stephen Stein2; Alexey Nesvizhskii1;
1
University of Michigan, Ann Arbor, MI; 2National Institute of
Standards and Technology, Gaithersburg, MD
WP 579 Peptide de novo Sequencing Result Validation; Lian
Yang1; Baozhen Shan1; Bin Ma2; 1Bioinformatics Solutions
Inc., Waterloo, Ontario; 2University of Waterloo, Waterloo,
Canada
WP 580 Whole Protein de novo Sequencing with LC-MS/
MS; Lian Yang1; Baozhen Shan1; Mingjie Xie1; Bin Ma2;
1
Bioinformatics Solutions Inc., Waterloo, ON; 2University of
Waterloo, Waterloo, Canada
WP 581 Computational Methods for Untargeted Protein
Identification Using Data Independent SWATH
Acquisition; Chih-Chiang Tsou1; Monika Tucholska2;
Brett Larsen2; Anne-Claude Gingras2; Alexey Nesvizhskii1;
1
University of Michigan, Ann Arbor, MI; 2Samuel Lunenfeld
Research Institute, Toronto, Canada

61ST ASMS CONFERENCE ON MASS SPECTROMETRY						

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GENERAL
INFORMATION
WEDNESDAY
POSTERS

WP 582 Hypothesis-driven Analysis: An Alternative Approach
to Handle Data-Independent Acquisition Data of
Peptides from a Novel Hybrid Orbitrap (Q-OT-qIT) Mass
Spectrometer; Ying Sonia Ting 1; Jarrett D. Egertson1;
Gennifer E. Merrihew1; Richard S. Johnson1; Lukas Käll2;
Jesse D. Canterbury3; Reiko Kiyonami3; Michael Senko3;
Vlad Zabrouskov3; Brendan MacLean1; William Stafford
Noble1; Michael J. MacCoss1; 1University of Washington,
Seattle, WA; 2Royal Institute of Technology, Solna, Sweden;
3
Thermo Fisher Scientific, San Jose, CA
WP 583 Fragmentation Patterns of EThcD Spectra of
Phosphopeptides and Glycopeptides; Marshall Bern1;
Yong J. Kil1; Wilfred Tang1; Chris Becker1; Christian Frese2;
Maarten Altelaar2; Shabaz Mohammed2; Albert Heck2; John
Syka3; Ryan Bomgarden3; Rosa Viner3; 1Protein Metrics Inc.,
San Carlos, CA; 2Utrecht University, Utrecht, Netherlands;
3
Thermo Fisher Scientific, San Jose, CA
WP 584 Annotating the R. norvegicus Genome Using Mass
Spectrometry; Jennifer Teubl1; Manor Askenazi3; Meera
Prasad1; Peter Lobel2; David Fenyo1; 1NYU Langone
Medical Ctr, Ny, NY; 2Rutgers University, Piscataway, NJ;
3
The Ionomix Initiative, Arlington, MA
WP 585 Identifying Proteins in Zebrafish Embryos Using
Spectral Libraries Generated from Dissected Adult
Organs and Tissues; Suzanne J. van der PlasDuivesteijn1; Yassene Mohammed1; Hans Dalebout1;
Annemarie H. Meijer2; Alex A. Henneman1; André M.
Deelder1; Herman P. Spaink 2; Magnus Palmblad1; 1Leiden
University Medical Center, Leiden, The Netherlands; 2Leiden
University, Leiden, The Netherlands
WP 586 Integrative Genome, Transcriptome and Proteome
Analysis of Rat Livers from Two Different Genetic
Backgrounds; Teck Yew Low1; Sebastian van Heesch2;
Henk van den Toorn1; Piero Giansanti1; Alba Cristobal1; Bas
van Breukelen1; shabaz Mohammed1; Victor Guryev3; Edwin
Cuppen2; Albert J.R. Heck1; 1University of Utrecht, Utrecht,
Netherlands; 2Hubrecht Institute, Utrecht, Netherlands;
3
University of Groningen, Groningen, Netherlands
WP 587 iPRG-2013: Proteome Informatics Research Group
Study: Using RNA-Seq Data to Refine Proteomic Data
Analysis; Robert Chalkley1; Nuno Bandeira2; Matthew
Chambers3; John Cottrell4; Eric Deutsch5; Eugene Kapp6;
Henry Lam7; Thomas Neubert8; Rui-Xiang Sun9; Olga
Vitek10; Susan Weintraub11; 1UCSF, San Francisco, CA;
2
University of California, San Diego, CA; 3Vanderbilt
University Medical Center, Nashville, TN; 4Matrix Science
Ltd, London, UK; 5Institute for Systems Biology, Seattle,
WA; 6Walter & Eliza Hall Institute of Medical Research,
Melbourne, Australia; 7University of Science and
Technology, Hong Kong, China; 8New York University
School of Medicine, New York, NY; 9Chinese Academy
of Sciences, Beijing, China; 10Purdue University, West
Lafayette, IN; 11University of Texas Health Science Center,
San Antonio, TX
WP 588 Impact of Amino Acid Substitutions on Peptide
Fragmentation Pattern in Tandem Mass Spectrometry;
Chao Ji; Randy Arnold; Haixu Tang; Predrag Radivojac;
Indiana University, Bloomington, IN
WP 589 A Proteogenomic Workflow to Enhance the Annotation
of Novel Microbial Genomes: Case Study of T.
thermohydrosulfuricus WC1; Tobin J. Verbeke; Vic Spicer;
Richard Sparling; David Levin; Oleg V. Krokhin; University of
Manitoba, Winnipeg, Canada
WP 590 Using Orthogonal Techniques for Protein-Peptide
Separation to Generate Comprehensive HDMSe Mass
Spectral Libraries from an E. coli Model System; Justin
D. Topp3; Michael Nold5; Ezra S. Abrams2; Charles L.
Farnsworth1; Scott Geromanos5; Manor Askenazi4; Jeffrey

PAGE 144					

WP 591

WP 592

WP 593

WP 594

WP 595

WP 596

C. Silva1; 1Cell Signaling Technology, Danvers, MA; 2Sage
Science Inc., Beverly, MA; 3Gordon College, Wenham, MA;
4
The Ionomix Initiative, Arlington, MA; 5Waters Corporation,
Milford, MA
Importing Data into Protein Prospector’s MS-Viewer;
Peter R Baker; Alma Burlingame; Robert Chalkley; UCSF,
San Francisco, CA
Development of High Resolution MS/MS Library of
Peptides from Protein Digestion; Xiaoyu Yang; Pedatsur
Neta; Lisa Kilpatrick; Yuri Mirokhin; Yuxue Liang; Dmitrii
Tchekhovskoi; Jeri Roth; Stephen Stein; NIST, Gaithersburg, MD
Combining Demultiplexing and Label-free Quantification
for High-resolution Data-independent Acquisition
LC-MS/MS Analyses; Aivett Bilbao1, 2; Ying Zhang1;
Dario Bottinelli1; Bandar Alghanem1; Frédéric Nikitin2;
Jeremy Luban3; Caterina Strambio De Castillia3; Markus
Mueller2; Frédérique Lisacek2; Emmanuel Varesio1; Gérard
Hopfgartner1; 1University of Geneva, Geneva, Switzerland;
2
Swiss Institute of Bioinformatics, Geneva, Switzerland;
3
University of Massachusetts, Worcester, MA
Optimization of MS/MS Spectral Library Searching for
High Mass Accuracy Spectra of Peptides; Kan Zhu;
Wenguang Shao; Yingwei Hu; Henry Lam; The Hong Kong
University of Science and Technology, Hong Kong, China
OpenSWATH: Automated, Targeted Analysis of Mass
Spectrometric Data Generated by Data-Independent
Acquisition; Hannes Roest1; George Rosenberger1;
Pedro Navarro1; Ludovic Gillet1; Sasa Miladinovic1, 2; Olga
Schubert1; Witold Wolski4; Johan Malmstroem3; Lars
Malmstroem1; Ruedi Aebersold1; 1ETH Zurich, Zurich,
Switzerland; 2Biognosys AG, Schlieren, Switzerland;
3
Department of Immunotechnology, Lund University, Lund,
Sweden; 4SyBIT project of SystemsX.ch, Zurich, Switzerland
Software for Integrated and Interactive Visualization of
LC-MS Data and Peptide Identification Results; Zefeng
Zhang; Bioinformatics Solutions Inc., Waterloo, Canada

Informatics: Post-Translational Modifications, 597 – 607
WP 597 Identification of Putative PTM Cross-Talk Motifs from
Large-Scale Experimental Datasets; Mao Peng; Arjen
Scholten; Albert J.R. Heck; Bas van Breukelen; Utrecht
University, Utrecht, Netherlands
WP 598 GlycoMap_Align: An Application for Annotation of
Glycoproteins through Alignment of Glycomaps;
Abhinav Mathur1; Anoop Mayampurath1; Chuan-Yih Yu1;
Ehwang Song2; Yehia Mechref2; Haixu Tang1; 1Indiana
University, Bloomington, IN; 2Texas Technical University,
Lubbock, TX
WP 599 Characterization of a-N-methylation of Centromere
Protein CENP-B; Xiaoxia Dai1; Zi Wang1; Koichiro Otake2;
Changjun You1; Qian Cai1; Hiroshi Masumoto2; Yinsheng
Wang1; 1University of California, Riverside, CA; 2Kazusa
DNA Research Institute, Kisarazu, Japan
WP 600 Synthesis, Fragmentation and RPLC Separation of
S-Palmitoyl Peptides; Zhiyu Li; Vikas Pejaver; Randy
Arnold; Suchetana Mukhopadhyay; David Clemmer; Predrag
Radivojac; Indiana University - Bloomington, Bloomington, IN
WP 601 An Informatics Workflow for the Analysis of the Heavily
N-glycosylated gp120; Audra Hargett1; Milan Raska1,
2
; Stacy Hall1; Qing Wei1; Katerina Zachova2; Zhi-Qiang
Huang2; Lydie Czernekova2; Zina Moldoveanu1; Jan Novak1;
Amol Prakash3; Chris Becker4; Marshall Bern4; Scott
Peterman3; Mattew B. Renfrow1; 1University of Alabama
at Birmingham, Birmingham, AL; 2Palacky University in
Olomouc, Olomouc, Czeck Republic; 3ThermoFisher
Scientific, San Jose, CA; 4Protein Metrics, San Carlos, CA

61ST ASMS CONFERENCE ON MASS SPECTROMETRY

WEDNESDAY POSTERS

WP 602 A Phospho-peptide Spectrum Library for Improved
Targeted Assays; Barbara Frewen1; Scott Peterman1;
Bryan Krastins1; Gregory Byram1; David Sarracino1; John
Sinclair2; Claus Jorgensen2; Amol Prakash1; Mary Lopez1;
1
Thermo Fisher Scientific, BRIMS, Cambridge, MA; 2The
Institute of Cancer Research, London, UK
WP 603 Sipros/ProRata: A Software Package for Identification
and Quantification of Proteins, Modifications and
Stable Isotope Incorporation in Microbial Communities;
Yingfeng Wang; Tae-Hyuk Ahn; Zhou Li; Chongle Pan; Oak
Ridge National Lab, Oak Ridge, TN
WP 604 Detecting Drug Induced Protein Adducts with Tandem
Mass Spectrometry; Markus Muller1; Paola Antinori
Malaspina2, 3; Adelina Acosta Martin2, 3; Youssef Daali4;
Denis Hochstrasser4; Pierre Lescuyer2, 4; Alexandre Scherl2,
3 1
; SIB, Geneva, Switzerland; 2Biomedical Proteomics
Research Group, Geneva, Switzerland; 3Swiss Center of
Applied Human Toxicology, Geneva, Switzerland; 4Geneva
University Hospitals, Geneva, Switzerland
WP 605 STRAP PTM: Differential Characterization by PTM
Counting and Much More; Jean L. Spencer; Vivek N.
Bhatia; Stephen A. Whelan; Christian F. Heckendorf;
Catherine E. Costello; Mark E. McComb; Boston University
School of Medicine, Boston, MA
WP 606 A Robust Mechanism to Capture Protein Evidences
and PTMs in UniprotKB; Pierre-Alain Binz 1; Edouard
de Castro1; Nicole Redaschi1; Delphine Baratin1; Severine
Duvaud1; Lydie Bougueleret1; Ioannis Xenarios1; Alan
Bridge1; The UniProt Consortium1, 2; 1Swiss Institute of
Bioinformatics, Geneva 4, Switzerland; 2EBI and PIR,
Hinxton and Washington, UK and DC
WP 607 Unbiased Phosphopeptide Analysis Using the
Distributions of All Theoretically Possible Peptides;
Rovshan Sadygov; University of Texas, Galveston, TX

WP 614

WP 615

WP 616

WP 617

WP 618

WP 619

WP 620

Peptides: Quantitative Analysis II, 608 – 643
WP 608 NeuQuant: An Open-Access Software Toolbox
for Neutron Encoded (NeuCode) Quantification
Technologies; Anna E. Merrill; Alexander S. Hebert; Derek
J. Bailey; Michael S. Westphall; Joshua J. Coon; University
of Wisconsin, Madison, WI
WP 609 Direct Comparison of Metabolic Labeling by SILAC and
Chemical Labeling by Stable Isotope Dimethyl Labeling
in Single Runs; Ho-Tak Lau; Hyongwon Danny Suh; ShaoEn Ong; Univ of Washington, Seattle, WA
WP 610 Absolute Quantification of Cellular Ras Isoform
Abundance Using PSAQ and Dynamic SILAC Coupled
with SRM; Craig Mageean1; John Griffiths2; Yvonne
Connolly2; Michael Clague1; Duncan Smith2; Ian Prior1;
1
University of Liverpool, Crown Street, UK; 2Paterson
Institute for Cancer Research, Manchester, UK
WP 611 SILAC Labeling and Mass Spectral Analysis Reveals
Temporal Changes in Nbn Protein Interactions and
PTMs in Response to DNA Damage; Andrea Matlock1;
Philip Compton2; Dina Bai3; Jeffrey Shabanowitz3; Patrick
Concannon4; Donald Hunt3; 1UCLA, Los Angeles, CA;
2
Northwestern, Evanston, IL; 3University of Virginia,
Charlottesville, VA; 4University of Florida, Gainsville, FL
WP 612 Study on the Mechanism of Palmitate-Induced Insulin
Resistance in C2C12 Myoblasts Using SILAC Based
Quantitative Proteomic Analysis; Xiulan Chen; Shasha
Wei; Fuquan Yang; Institute of Biophysics, CAS, Beijing,
China
WP 613 Incorporation Rate of Heavy Isotope-labeled Lysine in
Non-Generational Metabolic Labeling in Mice; Tasha
Agreste1; Michael Ford2; Richard Jones2; Kevin Millis1;

WP 621

WP 622

WP 623

John C. Rogers 3; 1Cambridge Isotope Laboratories,
Andover, MA; 2MS Bioworks, Ann Arbor, MI; 3Thermo Fisher
Scientific, Rockford, IL
Quantitative Dimethyl Labeling Strategy for the
Investigation of the Global Effects of Aneuploidy on
the Proteome; Leigh Weston1; Kerry Bauer1; Darawalee
Wangsa2; Thomas Ried2; Amanda Hummon1; 1University of
Notre Dame, Notre Dame, IN; 2National Institutes of Health,
Bethesda, MD
Cross Validation of MALDI-TOF MS Label Free Profiling
and LC/MS Based Stable Isotopic Labeling Strategies
for Peptide Quantitation; Sarah Dowd; Elena Romanova;
Jonathan Sweedler; University of Illinois at UrbanaChampaign, Urbana, IL
Development of Novel 8-plex N,N-dimethylated Leucine
(DiLeu) Isobaric Labels for Quantitative Proteomics and
Peptidomics; Tyler Greer; Dustin Frost; Feng Xiang; Zhidan
Liang; Lingjun Li; University of Wisconsin, Madison, WI
Improving High Throughput in Relative Protein
Quantitation from 6 to 10 Plex; Rosa Viner1; Ryan
Bomgarden2; Michael Blank1; John Rogers2; 1ThermoFisher
Scientific, San Jose, CA; 2Thermo Fisher Scientific,
Rockford, IL
Assessing Non-Mitotic Pathways of an Aurora Kinase
Inhibitor Using Chemical Labelling and Label-Free MS
Approaches; Matthew McKay; Judith Nicholson; Mark
Molloy; APAF, Macquarie University, Sydney, Australia
Application of Microbore Hollow Fiber Enzymatic
Reactor (mHFER)-based 18O-labeling Approach to
Quantitative Proteomics; Sun Young Lee; So-Young Kim;
Dukjin Kang; Korea Research Institute of Standards and
Science, Daejeon, South Korea
ABRF-sPRG 2013 Study: Development and
Characterization of a Stable Isotope Labeled Peptide
Standard for Quantitative Proteomics Applications;
Christopher Colangelo 1; Craig Dufresne2; Alexander
Ivanov3; Antonius Koller4; Brett Phinney5; Kristie Rose6; Paul
Rudnick7; Brian Searle8; Scott Shaffer9; 1Yale University,
New Haven, CT; 2Thermo Fisher Scientific, West Palm
Beach, FL; 3Northeastern University, Boston, MA; 4Stony
Brook University, Stony Brook, NY; 5University of California,
Davis, CA; 6Vanderbilt University, Nashville, TN; 7National
Institute of Standards and Technology, Gaithersburg,
MD; 8Proteome Software, Portland, OR; 9University of
Massachusetts Medical School, Worcester, MA
Trimethylation Enhancement using Diazomethane
(TrEnDi): Rapid On-Column Methylation of Peptides and
Proteins to Permit Quantitative Analysis Using Tandem
Mass Spectrometry; Karl Wasslen; Stephen Wood;
Jeffrey Manthorpe; Jeffrey C. Smith; Carleton University,
Department of Chemistry, Ottawa, Canada
Intestinal Proteome Study in Insulin-Resistant Patients
by a Combination of iTRAQ, MRM and SWATH; Sylvie
Bourassa1; Isabelle Kelly1; Benjamin Nehmé1; Frédéric
Fournier1; André J. Tremblay2; Benoit Lamarche2; Patrick
Couture2; Arnaud Droit1, 3; 1CHU de Quebec Research
Center, Laval University, Quebec, Canada; 2INAF, Laval
University, Quebec, Canada; 3Department of Molecular
Medicine, Laval University, Quebec, Canada
Quantitative Assessment of Differential Protein
Expression in the Hemicellulolytic Bacterium
Clostridium stercorarium Using iTRAQ and SWATH
approaches; Peter D. Mcqueen1, 2; John Schellenberg1; Vic
Spicer1; Richard Sparling1; David Levin1; John Wilkins1, 2;
Oleg Krokhin1, 2; 1University of Manitoba, Winnipeg, Canada;
2
Manitoba Centre for Proteomics and Systems Biology,
Winnipeg, Canada

61ST ASMS CONFERENCE ON MASS SPECTROMETRY						

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INFORMATION
WEDNESDAY
POSTERS

WP 624 Highly Sensitive Determination of Therapeutic Peptides
in Human Plasma Using Orthogonal HILIC-RP Column
Switching and Tandem Mass Spectrometric Detection;
Eric W. Ma; Moucun Yuan; Michael Tingler; William Mylott
Jr; Bruce Hidy; Rand Jenkins; PPD, Richmond, VA
WP 625 Improved Identification and Relative Quantification
of Sites of Oxidation in Model Peptides and Protein
Systems by Electron-Transfer Dissociation (ETD);
Xiaoyan Li; Joshua S. Sharp; Complex Carbohydrate
Research Center, UGA, Athens, GA
WP 626 Comparison of Peptide Fragmentation and Bioanalysis
among Different LC/MS Approaches for the
Quantification of Glucagon and Its Analogs in Plasma;
Hang Zeng 1; Zhenmin Liang1; Catherine Bentzley2; David
Moore1; 1HL Roche, Inc., Nutley, NJ; 2University of the
Sciences, Philadelphia, PA
WP 627 An Augmented Label-Free Differential Analysis
Workflow Enhances Peptide Identifications and
Understanding of Alcohol Preference; Scott Goulding1;
Nicholas Bateman 2; Nicholas Shulman3; Michael MacCoss3;
Karen Szumlinski4; Christine Wu2; 1University of Colorado
Anschutz Medical Campus, Aurora, CO; 2University of
Pittsburgh, Pittsburgh, PA; 3University of Washington,
Seattle, WA; 4University of California, Santa Barbara, CA
WP 628 Proteomics Profiling of Cancer Cell Lines Using High
Flow Chromatography and Electrospray Ionization
Technique; Vadiraja B. Bhat 1; Dawn Stickle1; Anne E.
Blackwel1; Umesh T. Sankpal2; 1Agilent Technologies,
Wilmington, DE; 2MD Anderson Cancer Center Orlando,
Orlando, FL
WP 629 Liver Mitochondria Proteomics Employing High
Resolution MS Technology; Jenny T.C. Ho1; Loïc Dayon2;
John Corthésy2; Umberto De Marchi2; Antonio Núñez2;
Andreas Wiederkehr2; Rosa Viner3; Michael Blank3; Steven
Danielson3; Madalina Oppermann1; Martin Hornshaw1;
Martin Kussmann2, 4; 1Thermo Fisher Scientific, Hemel
Hempstead, UK; 2Nestlé Institute of Health Sciences,
Lausanne, Switzerland; 3ThermoFisher Scientific, San Jose,
CA; 4Ecole Polytechnique Fédérale Lausanne (EPFL),
Lausanne, Switzerland
WP 630 Method Optimization for Cardiovascular Proteomic
Mass SpectrometryAnalysis of Reversible Cysteine
Oxidation in CatTG Mice; Chunxiang Yao1, 2; Jessica
Behring2; Deborah A. Siwik3; Catherine E. Costeool1; Wilson
Colucci3; Richard A. Cohen2; Mark E. McComb1, 2; Markus
M. Bachschmid1, 2; 1CPC and CBMS, BUSM, Boston, MA;
2
Viscular BIology Section, BUSM, Boston, MA; 3Myocardial
BIology Unit, BUSM, Boston, MA
WP 631 Large Molecule Quantification by HRAMS: “Sensitive
Calcitonin Bioanalysis Using Targeted Selected Ion
Monitoring and High Resolving Power”; Jean-Nicholas
Mess1; Louis-Philippe Morin1; Gene Ciccimaro2; Maroun El
Khoury3; Fabio Garofolo 1; 1Algorithme Pharma Inc., Laval,
Quebec, Canada; 2Thermo Scientific, Sommerset, NJ;
3
Thermo Scientific, Montreal, Quebec, Canada
WP 632 Comprehensive Cancer Cell Proteomics: Providing a
Global Counterpoint to Genomic Approaches; Corey
Bakalarski1; Richard Neve1; Mamie Yu1; Suresh Selvaraj1;
Anthony Possemato2; Sean Beausoleil2; Peng Yue1; David
Dornan1; Richard Bourgon1; William Forrest1; Donald
Kirkpatrick1; 1Genentech, South San Francisco, CA; 2Cell
Signaling Technology, Danvers, MA
WP 633 Reduced Abundance of Protein Phosphatase 1
Regulatory Subunit 12B in Diabetes Revealed by
Targeted Proteomics; Monique Lewis; Danjun Ma; Michael
A. Caruso; Xiangmin Zhang; Zhengping Yi; Wayne State
University, Detroit, MI

PAGE 146					

WP 634 The Analysis of Human Parathyroid Hormone 1-34
(Teriparatide) by LC-MS/MS: Challenges and Lessons
Learned; Erin E. Chambers1; Mary Lame1; Jon Bardsley2;
Eileen Collins2; Sally Hannam2; Elizabeth Thomas2; Kenneth
J. Fountain1; 1Waters Corporation, Milford, MA; 2ICON PLC,
Manchester, UK
WP 635 Identification and Quantification of Peptide Hormones
in Sea Lamprey Brain Tissues by Electrospray
Ionization Tandem Mass Spectrometry; Huiyong Wang;
Yu-Wen Chung-Davidson; Ke Li; Weiming Li; Michigan State
University, East Lansing, MI
WP 636 Casein Kinase I δ Substrates Associated with Migraine;
Huan Kang; Emily Bates; John Prince; Brigham Young
University, Provo, Utah
WP 637 A Detergent Free, Label Free Quantification Method
with High Sensitivity and Throughput for CYP Enzymes
via LC/MS/MS; Ji Zhang; Jimmy Li; Bingli Ma; Cindy Xia;
Jing-Tao Wu; Matt Jones; Millennium :The Takeda Oncology
Company, Cambridge, MA
WP 638 Proteomic Analysis of Rhizome Specificity across
Plant Kingdom; Fernanda Salvato; University of Missouri,
Columbia, MO
WP 639 Quantitation of Low Levels of Heat Shock Protein 90 in
Serum of Cervical Cancer Patients by Selected Reaction
Monitoring; Coskun Guzel 1; Natalia I. Govorukhina2;
Klaske A. ten Hoor3; Lennard J.M. Dekker1; Harry Hollema3;
Harry G. Klip3; Ate G.J. van der Zee3; Alexander Boichenko
‎ Boichenko ‎2; Rainer Bischoff 2; Theo M. Luider1; 1Erasmus
Medical Center, Rotterdam, the Netherlands; 2University of
Groningen, Groningen, the Netherlands; 3University Medical
Centre Groningen, Groningen, the Netherlands
WP 640 Challenge in Trying to Reach Femtogram per Milliliter
(fg/mL) Sensitivity in Plasma for the Quantification of
a Cyclic Peptide: Desmopressin; Louis-Philippe Morin1;
France Landry1; Jean-Nicholas Mess1; Kelli Jonakin2; Mauro
Aiello2; Xavier Misonne2; Gary Impey2; Johnny Cardenas2;
Fabio Garofolo 1; 1Algorithme Pharma Inc., Laval, Quebec,
Canada; 2AB Sciex, Concord, Ontario, Canada
WP 641 Absolute Quantitation of Yeast Kinases by Means of
LC-MS/MS Using QconCat and SRM Technologies;
Philip J Brownridge1; Victoria Harman1; Simon Cubbon2;
Johannes PC Vissers2; Craig Lawless3; Simon J Hubbard3;
Robert J Beynon1; 1Protein Function Group, University of
Liverpool, Liverpool, UK; 2Waters Corporation, Manchester,
UK; 3Faculty of Life Sciences, University of Manchester,
Manchester, UK
WP 642 Detection of HIV Peptides Using Selective Reaction
Monitoring Mass Spectrometry: An in vitro Study;
Xiaolin Li; John C Tilton; Daniela M Schlatzer; Case
Western Reserve University, Cleveland, OH
WP 643 Glucagon Bioanalysis by LC-MS: “Unprecedented Level
of Sensitivity (10pg/mL) for a Novel Formulation”; JeanNicholas Mess1; Louis-Philippe Morin1; Mauro Aiello2; Xavier
Misonne2; Gary Impey2; Johnny Cardenas2; Josee Michon1;
Fabio Garofolo 1; 1Algorithme Pharma Inc., Laval - Quebec,
Canada; 2AB SCIEX, Concord - Ontario, Canada
Phosphopeptides: Enrichment Methods, 644 – 668
WP 644 Application of Immobilized Metal Ion Affinity
Chromatography (IMAC) Enrichment for Bacterial
Phosphopeptide Analysis; Yi Qu; Si Wu; Rui Zhao; Erika
Zink; Daniel Orton; Ronald Moore; Da Meng; Therese
Clauss; Joshua Aldrich; Mary Lipton; Ljiljana Paša-Tolić;
PNNL, Richland, WA

61ST ASMS CONFERENCE ON MASS SPECTROMETRY

WEDNESDAY POSTERS

WP 645 Differentiation of Ion Exchange Materials for
Phosphopeptide Fractionation; Qing-Run Li; QingQing Wu; Rong Zeng; Shanghai Institutes for Biological
Sciences, Shanghai, China
WP 646 The Phosphopeptide Shootout: A Study of
Reproducibility in IMAC Phosphopeptide Enrichment;
Nicholas M. Riley; Gregory K. Potts; Michael S. Westphall;
Joshua J. Coon; University of Wisconsin, Madison, WI
WP 647 An Enzyme Assisted RP-RPLC Approach for In-Depth
Human Liver Phosphoproteome Analysis; Yangyang
Bian1; Chunxiao Song1; Mingming Dong1; Wenhai Jin2; Lihai
Guo2; Yongming Xie2; Mingliang Ye1; Hanfa Zou1; 1Dalian
Institute of Chemical Physics, Dalian, Liaoning Province,
China; 2Asia Pacific Application Support Center, AB SCIEX,
Shanghai, China
WP 648 Reducing Sample Size and Improving Numbers of
Identified Proteins: Phosphoproteomic Studies with
SCX-IMAC and IMAC-RP Methods; Xiaoshan Yue;
Amanda Hummon; Notre Dame, Notre Dame, IN
WP 649 Comparison of Resins for Metal Oxide Affinity
Chromatography with Mass Spectrometry Detection
for the Determination of Phosphopeptides; Ales Tichy1;
Barbora Salovska2; Ivo Fabrik1; Jirina Vavrova1; 1University
of Defence, Hradec Kralove, Czech Republic; 2Faculty of
Medicine, Hradec Kralove, Czech Republic
WP 650 Dimetal Phosphate Ester Stabilization and StrongCation Exchange Chromatography (DIMPES-SCX):
A Novel Approach for Phosphopeptide Enrichment;
Thiago Verano-Braga; Simon Svane; Christine McKenzie;
Frank Kjeldsen; University of Southern Denmark, Odense,
Denmark
WP 651 A Streamlined Protocol for High Content
Phosphoproteomics; Francesca Zappacosta; Gilbert
Scott; Michael Huddleston; Dean McNulty; Timothy Sikorski;
Roland Annan; GlaxoSmithKline, Collegeville, PA
WP 652 Enhanced Phosphopeptide Identification in Bacteria
by Stepwise Hydroxy Acid-Modified Metal Oxide
Chromatography with Elevated Sample Loading
Capacity; Miao-Hsia Lin; Yasushi Ishihama; Kyoto
university, Kyoto, Japan
WP 653 Highly Specific Phosphopeptide Enrichment Using
a Novel Tantalum-based Sol-gel for MALDI-MS
Applications; Ömür Çelikbıçak; Mehmet Atakay; Ülkü
Güler; Bekir Salih; Hacettepe University, Department of
Chemistry, Ankara, Turkey
WP 654 A Mild Phosphopeptide Desorption Strategy in Anion
Exchange Based Enrichment Applications for Mass
Spectrometry Analysis; Mehmet Atakay; Ömür Çelikbıçak;
Bekir Salih; Hacettepe University, Department of Chemistry,
Ankara, Turkey
WP 655 Close Examination of Tyrosine Phosphopeptide
Enrichment and Its Application to Syk and Lyn
Signaling Pathways; Keerthi Jayasundera; Anton Iliuk;
Shenrui Mahorney; Liang Xue; Andrew Nguyen; Robert
Geahlen; W. Andy Tao; Purdue University, West Lafayette,
IN
WP 656 Improved Identification of Akt Substrate Motif
Phosphorylation in LC-MS/MS with a Tandem Affinity
Enrichment Approach; Taylur Ma; Victoria Pham; Jennie
Lill; Kebing Yu; Genentech, Inc., South San Francisco, CA
WP 657 Targeted Phosphoproteomics Analysis of
Immunoaffinity Enriched Tyrosine Phosphorylation in
Mouse tissue; Ravi Kumar Krovvidi1; Leo Bonilla1; Charles
L Farnsworth 2; Jeffrey C Silva2; 1Agilent Technologies India
Pvt. Ltd, Bangalore, India; 2Cell Signaling Technology, Inc,
Danvers, CT

WP 658 Complementation of Ti, Zr and Fe-based PolyMAC
for In-Depth Phosphoproteome Analysis of B cell
Signaling; Anton Iliuk1; Keerthi Jayasundera2; Wen-horng
Wang2; Robert Geahlen2; Weiguo Andy Tao2; 1Tymora
Analytical Operations, West Lafayette, IN; 2Purdue
University, West Lafayette, IN
WP 659 Quantitative Profiling of Signaling Pathways Using
Immunoaffinity Purification and LC-MS/MS; Matthew P.
Stokes; Jian Min Ren; Kimberly A. Lee; Xiaoying Jia; Jeffrey
C. Silva; Cell Signaling Technology, Danvers, MA
WP 660 A Novel Strategy Employing a Phosphatase Trapping
Mutant for the Enrichment of Phosphoarginine, an
Unconventional Type of Protein Phosphorylation;
Débora Broch Trentini; Tim Clausen; Karl Mechtler; Institute
of Molecular Pathology (IMP), Vienna, AUSTRIA
WP 661 Sunny-side Up: First UV MALDI-ToF-MS
Phosphopeptide Analysis Using a Solidified Ionic
Liquid Matrix (SILM); Gargee Mukherjee1; Claudia
Röwer1; Manuela Russ1; Chris Protzel2; Oliver Hakenberg2;
Cornelia Koy1; Michael O. Glocker 1; 1Proteome Center
Rostock, Rostock, Germany; 2Urology Clinic and Polyclinic,
University Medicine, Rostock, Germany
WP 662 Old Tools in a New Jacket: Phosphopeptide Enrichment
by TiO2 and IMAC Columns; Simone Lemeer; Benjamin
Ruprecht; Heiner Koch; Max Mundt; Bernhard Kuster;
Technische Universität München, Freising, Germany
WP 663 The Phosphoproteome of Chlamydomonas reinhardtii
Determined by TiO2-HILIC and HILIC-PolyMAC
Workflows Coupled to nanoLC-MS/MS; Brian Gau;
Hongxia Wang; Leslie Hicks; Donald Danforth Plant Science
Center, St. Louis, MO
WP 664 Optimization of the β-Elimination/Michael Addition
Chemistry on Reversed-Phase Supports for
Comprehensive Phosphoprotein Characterization by
Mass Spectrometry; Heinz Nika1; David H. Hawke2; Ruth
Hogue Angeletti1; 1Albert Einstein College of Medicine,
Bronx, NY; 2UT- M.D. Anderson Cancer Center, Houston, TX
WP 665 Robust Enrichment Methods for Single-Shot
Phosphoproteomics of Cancer Cell Lines Enable
Signaling Network Analysis; Sander Piersma; Koen
van der Mijn; Bharath Sampadi; Inge de Reus; Jaco Knol;
Richard de Haas; Thang Pham; Henk Broxterman; Henk
Verheul; Connie Jimenez; VU University Medical Center,
Amsterdam, Netherlands
WP 666 Comprehensive Phosphorylation Site Analysis of α- S2
Casein Using Microwave-Assisted Acid Hydrolysis and
Phosphopeptide Enrichment; Zhendong Li; Nan Wang;
Liang Li; UofA, Edmonton, Canada
WP 667 Maximizing Phosphoproteome Profiling Using
Mascot, PEAKS Studio, Proteome Discoverer and
OMSSA Software Packages; Jayme Wiederin1; Melinda
Wojtkiewicz1; Pawel Olszowy2; Pawel Ciborowski1;
1
University of Nebraska Medical Center, Omaha, NE;
2
Nicolaus Copernicus University, Torun, Poland
WP 668 Motif Antibody Enrichment Enables the Identification
of a Large Discrete and Complementary Set Of
Phosphorylation Sites ; Anthony Possemato1; Sean
Beausoleil1; Mike Aguiar1; Kim Lee1; Steven Gygi2; 1Cell
Signaling Technology, Danvers, MA; 2Harvard Medical
School, Boston, MA
Advances in Separation Techniques for
Proteomic Applications, 669 – 684
WP 669 Detection of Biomarker of Oxidative Stress by Using
HPLC-MS/MS and a Microfluidic Electrochemical Array;
Boya Song; Shenmin Pan; Chi Tang; Dandan Li; James
Rusling; University of Connecticut, Storrs, CT

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WEDNESDAY
POSTERS

WP 670 Improved Sensitivity in Proteomics Experiments Using
DMSO in nanoESI-LC-MS/MS; Hannes Hahne1; Guillaume
Medard1; Stefan K. Maier1; Dominic Helm1; Matthias Wilm2;
Bernhard Kuster1; 1Technische Universitaet Muenchen,
Freising, Germany; 2University College Dublin, Dublin,
Ireland
WP 671 Zeptomole-level Proteomic Analysis of Limited
Availability Clinical Samples Using Monolithic and
Porous Layer Open Tubular Columns in Ultralow Flow
LC/MS; Alexander R. Ivanov; Siyang Li; Xianzhe Wang;
Barry L. Karger; Barnett Institute, Northeastern University,
Boston, MA
WP 672 A Comparison of Proteomic Data Sets Obtained from
Varied Experimental Approaches; Susan Slade1; James
Langridge3; Nisha Patel2; Joanne B. Connolly3; James
Scrivens1; 1Univ of Warwick, Coventry, UK; 2Department
of Chemistry, University of Oxford, Oxford, UK; 3Waters
Corporation, Manchester, UK
WP 673 Proteomic Studies on Enriched Cell Populations by
Linking Cell Sorting with Microfluidic Online Sample
Preparation and LC/MS; Jeffrey Martin; Tomas Rejtar;
Stephen Martin; Novartis Institutes for Biomedical Research,
Cambridge, MA
WP 674 The BluePippin Automated Size-Fractionation System
for Proteins; Ezra Abrams; Chris Boles; Sage Science,
Inc., Beverly, MA
WP 675 Comprehensive Genome-Wide Proteomic Analysis of
Human Placental Tissue for the Chromosome-Centric
Human Proteome Project; Hyoung-Joo Lee1; Seul-Ki
Jeong1; Keun Na1; Min Jeong Lee1; Sun Hee Lee1; JongSun Lim1; Hyun-Jeong Cha1; Jin-Young Cho1; Ja-Young
Kwon2; Hoguen Kim2; Si Young Song2; Jong Shin Yoo3;
Young Mok Park3; Hail Kim4; William S. Hancock 5; YoungKi Paik1; 1Yonsei Proteome Research Center, Seoul, South
Korea; 2Yonsei University College of Medicine, Seoul,
South Korea; 3Korea Basic Science Institute, Ochang,
South Korea; 4Korea Advanced Institute of Science
and Technology, Daejeon, South Korea; 5Northeastern
University, Boston, MA
WP 676 High Sensitivity Microproteomic Analysis of Rare
Samples by Porous Layer Open Tubular (PLOT)
Columns Coupled with Mass Spectrometry; Siyang Li;
Xianzhe Wang; Somak Ray; Barry L. Karger; Alexander R.
Ivanov; Barnett Institute, Northeastern University, Boston,
MA
WP 677 Comparison of Gas-Phase Fractionation and DataDependent Acquisition for Identification of Posttranslational Modifications in Glioma-Derived Stem-Like
Cells; Cheryl F. Lichti 1; Huiling Liu1; Erick P. Sulman2;
Frederick F. Lang2; Charles A. Conrad2; Carol L. Nilsson1;
1
UTMB-Galveston, Galveston, TX; 2The University of Texas
MD Anderson Cancer Center, Houston, TX
WP 678 Bottom-up Proteomics by Capillary Electrophoresis
and Mass Spectrometry; Anthonius A.M. Heemskerk;
Guinevere S.M. Kammeijer; Ekaterina Mostovenko; Bart
Schoenmaker; Rico J.E. Derks; André M. Deelder; Magnus
Palmblad; Oleg A. Mayboroda; Leiden University Medical
Center, Leiden, Netherlands
WP 679 Fully Automatable Multidimensional Liquid
Chromatography Systems for Shotgun Proteomics;
Yun Zhao1; C. H. Law1; Ricky P. W. Kong1, 3; Guohui Li1;
Herman C. Lam1; Jason Neo4; Simon M. Y. Lee2; C.Y. Ma1;
Ivan K. Chu1; 1The University of Hong Kong, Hong Kong,
China; 2The University of Macau, Macau, China; 3AB SCIEX
Hong Kong, Hong Kong, China; 4AB SCIEX Singapore,
Singapore, Singapore

PAGE 148					

WP 680 Bottom-Up Proteome Analysis of E. coli Using Capillary
Zone Electrophoresis-Tandem Mass Spectrometry with
an Electrokinetic Sheath-Flow Electrospray Interface;
Xiaojing Yan; David Essaka; Liangliang Sun; Guijie Zhu;
Norman Dovichi; University of Notre Dame, Notre Dame,
U.S.
WP 681 Single-Shot Capillary Zone Electrophoresis
Electrospray Ionization-Tandem Mass Spectrometry
Produces More Than 1,250 E. coli Peptide
Identifications in a 50-Minute Separation; Guijie Zhu;
Liangliang Sun; Xiaojing Yan; Norman Dovichi; University of
Notre Dame, Notre Dame, IN
WP 682 Integrated CZE-ESI-MS/MS System with Immobilized
Trypsin Microreactor for Picogram of RAW 264.7 Cell
Lysate Analysis; Liangliang Sun; Guijie Zhu; Norman J.
Dovichi; University of Notre Dame, South Bend, IN
WP 683 Precise Column Temperature Control Enables
Improved Protein Identifications in Proteomics ShotGun Sequencing Applications; Xiaoyue Jiang; Yi Zhang;
Andreas Huhmer; Thermo Fisher Scientific, San Jose, CA
WP 684 CE-ESI-MS for Top Down Proteomics; Yihan Li; John C.
Tran; Ioanna Ntai; Kenneth R. Durbin; Adam D. Catherman;
Philip D. Compton; Paul M. Thomas; Neil L. Kelleher;
Northwestern University, Evanston, IL
Interactions and Pathway Analysis, 685 – 706
WP 685 Rapid Identification of Differential Interactomes by
Affinity Purification Coupled with Data Independent
Mass Spectrometry Acquisition (AP-SWATHTM); JeanPhilippe Lambert1; Amber L. Couzens1; Gordana Ivosev2;
Brett Larsen1; Mikko Taipale3; Zhen-Yuan Lin1; Quan
Zhong4; Susan Lindquist3; Marc Vidal4; Ruedi Aebersold5;
Tony Pawson1; Ron Bonner2; Stephen Tate2; Anne-Claude
Gingras1; 1Samuel Lunenfeld Research Institute, Mount
Sinai H, Toronto, Canada; 2AB Sciex, Concord, Canada;
3
Whitehead Institute for Biomedical Research, Cambridge,
MA; 4Dana-Farber Cancer Institute, Boston, MA; 5Institute of
Molecular Systems Biology, ETH, Zurich, Switzerland
WP 686 Temporal Proteomics Unveils Ignicoccus hospitalis’s
Response to the Superficial Attachment and Growth
Progression of Its Commensal Partner, Nanoarchaeum
equitans; Richard J. Giannone; Louie L. Wurch; Mircea
Podar; Robert L. Hettich; Oak Ridge National Laboratory,
Oak Ridge, TN
WP 687 High-Resolution Interactome of the HSP90 Machinery
Reveals Specificity for Targets; Brett Larsen1; Mikko
Taipale2; Zhen-Yuan Lin1; George Tucker3; Guoci Teo4;
Hyungwon Choi4; Susan Lindquist2, 3; Anne-Claude
Gingras1, 5; 1SLRI, Toronto, Canada; 2Whitehead Institute for
Biomedical Research, Cambridge, MA; 3MIT, Cambridge,
MA; 4National University of Singapore, Singapore,
Singapore; 5Mount Sinai Hospital, Toronto, Canada
WP 688 Towards a Deep and Temporal Representation of
Protein Interaction Networks via AP-SWATH; Ben C.
Collins1; Ludovic C. Gillet1; George Rosenberger1; Hannes
L. Röst1; Matthias Gstaiger1; Ruedi Aebersold1, 2; 1ETH
Zurich, Zurich, Switzerland; 2University of Zurich, Zurich,
Switzerland
WP 689 Dynamic Analysis of HIV-Human Protein-Protein
Interactions During Infection; Jeffrey Johnson1; Shannon
Eliuk2; Amnon Golan1; Tasha Johnson1; Vlad Zabrouskov2;
Nevan Krogan1; 1UCSF, San Francisco, CA; 2Thermo Fisher
Scientific, San Jose, CA
WP 690 Quantitative Analysis of 6-Thioguanine-Induced
Changes in the Proteome of Jurkat-T Human Leukemia
Cells; Fan Zhang; Yinsheng Wang; University of California,
Riverside, CA

61ST ASMS CONFERENCE ON MASS SPECTROMETRY

WEDNESDAY POSTERS

WP 691 Quantitative Proteomic Analysis Reveals Chromiuminduced Perturbation of Multiple Cellular Pathways
in GM00637 Human Skin Fibroblast Cells; Lei Guo;
Yinsheng Wang; University of California, Riverside, CA
WP 692 Sphingosine-1-Phosphate Mediated Chemotaxis of
Osteoclast Precursors Investigated Using Targeted
Proteomics via Mass Spectrometry; Nathan Manes1;
Eunkyung An1; Virginie Sjoelund1; Jing Sun1; Bastian
Angermann1; Masaru Ishii2; Martin Meier-Schellersheim1;
Ronald Germain1; Aleksandra Nita-Lazar1; 1NIH, Bethesda,
MD; 2Osaka University, Osaka, Japan
WP 693 Dynamic Pathways in Acute Autophagy Elucidated by
Quantitative Label-free and SILAC-based Proteomics;
Robin Mathew1, 2; Saw Kyin2; Henry Shwe2; Eileen White1;
David H. Perlman2; 1The Cancer Institute of New Jersey,
New Brunswick, NJ; 2Princeton University, Princeton, NJ
WP 694 Towards a Comprehensive Understanding of Platelet
Activation and Platelet-Monocyte Interaction: Multiple
Proteomic Approaches in the Study of Atherosclerosis;
Jiqing Huang; Chengcheng Zhang; Ru Li; Juergen Kast;
BRC, Univ. of British Columbia, Vancouver, Canada
WP 695 Using Label-Free Mass Spectrometry Workflows to
Quantitatively Model Signal Transduction Pathways in
Cellular Systems and Clinical Samples; Jordy J. Hsiao;
Brandon H. Ng; Melinda M. Smits; Jiahui Wang; Michael E.
Wright; University of Iowa, Iowa City, IA
WP 696 MS-based Quantitative Analysis of RanBP2 in
Nucleocytoplasmic Transport; Samir Karaca1; Ketan
Thakar2; Ralph Kehlenbach2; Henning Urlaub1; 1Max Planck
Institute for Biophysical Chemistry, Goettingen, Germany;
2
Georg-August-University of Goettingen, Goettingen,
Germany
WP 697 Defining the Role for miR-27a in the Regulation of
Adipogenesis; Rebecca Leon; Bruce D. Pascal; Caitlin
Steckler; Patrick R. Griffin; Michael J. Chalmers; Scripps,
Jupiter, Fl
WP 698 Quantitative Analysis of Changes in Ubiquitination,
Protein Synthesis and Degradation Caused by Protein
Folding Stress Due to Inhibition of Hsp90; Manfredo
Quadroni1; Alexandra Potts1; Ivo Fierro-Monti1; Celine
Hernandez1, 2; Patrice Waridel1; Pablo Echeverria3; Didier
Picard3; 1University of Lausanne, Epalinges, Switzerland;
2
Swiss Institute of Bioinformatics, Lausanne, Switzerland;
3
University of Geneva, Geneva, Switzerland
WP 699 Investigation of Hepatocytes Transfected with
Cytochrome P450: Data Independent LC-MS Approach
to Identify and Quantify on a Multi-omic Scale; Suzanne
Geenen1; Lee A Gethings2; Cristian Cojocariu2; Janet
Hammond2; Giorgis Isaac3; Lucy Fernandes2; Robert
Tonge2; Johannes P.C. Vissers2; James Langridge2; Ian
Wilson1; Mark McDowall2; 1AstraZeneca, Macclesfield, UK;
2
Waters, Manchester, UK; 3Waters Corp, Milford, MA
WP 700 Understanding Oncoprotein Networks in Cancer Cells
Using Knock-In and Knock-Out AP-MS; Jing Song;
Zhenghe Wang; Rob Ewing; Case Western Reserve
University, Cleveland, OH
WP 701 Integrative Systems Approach towards Elucidation of
Action Mechanism for a Novel, First-In-Class ERK/AKT
Dual Inhibitor Anti-Cancer Drug; Giridharan Gokulrangan
1
; Daniela Schlatzer1; Neil Dhawan2; Eric Yuan3; Sahar
Mazhar3; Avi Ma’ayan2; Michael Ohlmeyer2; Mark Chance1;
Goutham Narla3; 1Center for Proteomics and Bioinformatics,
CWRU, Cleveland, OH; 2Mount Sinai School of Medicine,
New York, NY; 3Case Comprehensive Cancer Center,
Cleveland, OH

WP 702 Unraveling Metabolic Regulation by Real-Time Mass
Spectrometry of Living Cells; Tobias Fuhrer; Hannes
Link; Andreas Kühne; Uwe Sauer; Nicola Zamboni; ETH
Zürich, Zürich, Switzerland
WP 703 Proteome-Wide Analysis of Stress Response in E.
coli Using Super-SILAC Approach; Boumediene Soufi;
Andreas Harst; Karsten Krug; Boris Macek; Proteome
Center Tuebingen, Tuebingen, Germany
WP 704 Simple Quantitative Secretome Analysis of Conditioned
Media from Human Endothelial Stromal Cells Under
Hypoxic Conditions Characterizing Synthetic Progestin
Effects; John Shapiro3; Philip Gafken1; Michael Freitas2;
Ozlem Kayisli3; Umit Kayisli3; Saeed Faramarzi3; Murat
Basar3; Frederick Schatz3; Charles Lockwood3; 1Fred
Hutchinson Cancer Research Center, Seattle, WA; 2Ohio
State University, Columbus, OH; 3Ohio State University
College of Medicine, Columbus, OH
WP 705 Development and Application of a Multiplexed Active
Small GTPase Pull-down Assay Using Multiple Reaction
Monitoring; Chengcheng Zhang; Juergen Kast; University
of British Columbia, Vancouver, Canada
WP 706 Global Remodelling of Cellular Microenvironment
Due to Loss of Collagen VII; Victoria Kuettner1; Leena
Bruckner-Tuderman2; Joern Dengjel1; 1Freiburg University,
Freiburg, Germany; 2University Freiburg Medical Center,
Freiburg, Germany
Ambient Ionization: Applications II, 707 – 734
WP 707 Rapid Screening of Plasticisers in Gaskets for Glass
Food Jar Lids Using Atmospheric Pressure Solids
Analysis Probe-High Resolution Mass Spectrometry;
Malcolm Driffield1; Dennis Speck1; Mita Parmar1; Jennifer
Leak1; Liam Lister1; Emma Bradley1; Dominic Roberts2;
Sara Stead2; 1Food and Environmental Research Agency
(Fera), York, UK; 2Waters Corporation, Manchester, UK
WP 708 ASAP-HRMS: A Convenient Technique for
Characterizing Unexpected Insoluble Materials
Observed during the Development of Cosmetic
Formulae; Natali Budimir; Georges Hussler; L’Oréal
France, Aulnay Sous Bois, France
WP 709 Forensic Analysis Using Rapid Ambient Ionization
Techniques with High Resolution Mass Spectrometers;
Eshwar Jagerdeo; Jay Clark; Louis Reda; Jeffrey Leibowitz;
FBI, Springfield, VA
WP 710 Rapid Detection of Pomegranate Juice Adulteration
with Grape and Apple Juice Using DSA/TOF with
Minimal Sample Preparation and No Chromatography;
Avinash Dalmia; George Perkins; Craig Whitehouse;
Perkinelmer, Shelton, CT
WP 711 Tunable Desorption/Ionization with Plasma-based
Ambient Mass Spectrometry: Unraveling Mysteries
of Lithium-Ion Battery Degradation; Jake Shelley;
Christopher Kuhlmann; Britta Vortmann; Sascha Nowak;
Carsten Engelhard; University of Muenster, Muenster, Germay
WP 712 Fast Quantitation of bisphenol-A (BPA) in Plastic
Materials Using Desorption Corona Beam Ionization
and Probe Tip Column Electrospray Ionization Sources;
Chao Gao1; Yanjiao Wang2; Xiaoqiang Zhang1; Xiang Li2;
Wenjian Sun 1; 1Shimadzu Research Laboratory (Shanghai)
Co., Ltd., Shanghai, China; 2Fudan University, Shanghai,
China
WP 713 Overcoming Matrix effects: Quantitation of Explosives
via Ambient Ionization with Direct Sample Analysis;
Joshua A. Wilhide; Laura M. Nevin; Gregory T. Winter;
William R. LaCourse; Univeristry of Maryland Baltimore
County, Baltimore, MD

61ST ASMS CONFERENCE ON MASS SPECTROMETRY						

PAGE 149

GENERAL
INFORMATION
WEDNESDAY
POSTERS

WP 714 Analysis of Additives in Biodegradable Polymers Using
Direct Sampling Analysis (DSA) Time-of-Flight Mass
Spectrometry; Sharanya Reddy1; Rafael Auras2; Sergey
Rakov1; Craig Whitehouse1; George Perkins1; 1PerkinElmer,
Shelton, CT; 2Michigan State University, East Lansing, MI
WP 715 Rapid Screening of Parabens in Personal Care Products
using DSA/TOF with No Sample Preparation; Avinash
Dalmia; Thomas White; Fabian Oteiza; Carl Schwarz; Blas
Cerda; George Perkins; Perkinelmer, Shelton, CT
WP 716 Rapid Measurement of Olive Oil Adulteration with
Soybean Vegetable Oil with Minimal Sample Preparation
Using DSA/TOF; Avinash Dalmia; Nicola Vosloo; George
Perkins; Blas Cerda; Craig Whitehouse; Perkinelmer,
Shelton, CT
WP 717 Rapid Differentiation Between Natural and Artificial
Vanilla Flavorings Using DSA/TOF with no Sample
Preparation; Avinash Dalmia; George Perkins; Craig
Whitehouse; Perkinelmer, Shelton, CT
WP 718 Use of Sorbent Coated Metal Probes with Direct
Analysis in Real Time (DART) Ionization for Rapid
Analysis of Herbal Supplements; Joseph LaPointe;
Robert Goguen; Brian Musselman; Ionsense Inc., Saugus,
MA
WP 719 Characterizing Toothpastes: Direct Fingerprinting of
Key Volatile Flavor and Marker Non-volatile Compounds
by DART QToF Mass Spectrometry; Elizabeth Crawford1;
Brian Musselman2; Jerry Zweigenbaum3; 1Institute of
Chemical Technology Prague, Prague, Czech Republic;
2
IonSense, Inc., Saugus, MA; 3Agilent Technologies,
Wilmington, DE
WP 720 Pyrolysis for Rapid Screening of Contaminated Heparin
by DART Mass Spectrometry; Peter Nemes1; William
Hoover1; David Keire2; 1US FDA, CDRH, Silver Spring, MD;
2
US FDA, CDER, St. Louis, IL
WP 721 Rapid Screening of ‘White Powders’ for Unknown
Agents Using a DART-Equipped Compact Mass
Spectrometer; Jack Henion1; Brian Musselman2; Nigel
Sousou1; 1Advion, Inc., Ithaca, NY; 2IonSense, Saugus, MA
WP 722 High Resolution Accurate Mass (HRAM) Phthalate
Screening Using Direct Analysis in Real Time (DART)
Ambient Ionization; Catharina Crone1; Elizabeth
Crawford2; Yue Xuan1; Markus Kellmann1; 1Thermo Fisher
Scientific, Bremen, Germany; 2IonSense Inc., Saugus, MA
WP 723 Sensitive Screening of Abused Drugs in Raw Urine and
Blood by Direct Analysis in Real Time Triple Quadrupole
Mass Spectrometry; Wenfang Zhang1; Zong Yang2; Ping
Li3; Yong Chen4; Dazhou Chen2; Charles C. Liu5; 1Forensic
Science Service Public Security Bureau, Beijing, China;
2
National Institute of Metrology, Beijing, China; 3Lumtech
Technologies Limited, Beijing, China; 4Labcare Solutions,
Shanghai, China; 5ASPEC Technologies Limited, Beijing,
China
WP 724 Quantitation by DART-Orbitrap Mass Spectrometer:
Preliminary Analysis of Pesticides in Water by Internal
Standards; Jaewon Choi; Wonseok Choi; Jeheon Jang;
Yunduck Kim; Kwater, Daejeon, South Korea
WP 725 Exact and Quantitative Analysis of Deuterated Pyrene:
New Method for the Rapid, Convenient HydrogenDeuterium Exchange of Polycyclic Aromatic Hydrocarbons;
Mark Domin; Boston College, Chestnut Hill, MA
WP 726 Rapid Quantitative Analysis of Trimethyl Phosphate
in Water with Direct Analysis in Real Time Mass
Spectrometry; Xiaowei Wang1; Liping Liu1; Bing Shao1;
Jingfu Liu2; Charles C. Liu3; 1Beijing Center for Disease
Control and Prevention, Beijing, China; 2Chinese Academy
of Sciences, Beijing, China; 3ASPEC Technologies Limited,
Beijing, China

PAGE 150					

WP 727 Desorption Atmospheric Pressure PhotoionizationMass Spectrometry for the Direct Analysis of
Atmospheric Aerosols Collected on Quartz Filters;
Jevgeni Parshintsev1; Anu Vaikkinen1; Vladimír Vrkoslav2;
Josef Cvacka2; Risto Kostiainen1; Tapio Kotiaho1; MarjaLiisa Riekkola1; Tiina J Kauppila1; 1University of Helsinki,
Helsinki, Finland; 2Czech Academy of Sciences, Prague,
Czech Republic
WP 728 Implementation of Reactive Transmission Mode
Desorption Electrospray Ionization – Ketone and
Aldehyde Derivatization with Girard’s T Reagent; Alex
Bishop; Jennifer Brodbelt; University of Texas, Austin, TX
WP 729 Normal Phase Liquid Chromatography Coupled to
Continuous Flow – Extractive Desorption Electrospray
Ionization – Mass Spectrometry for Phospholipid
Analysis; Li Li; Kevin Schug; Univ of Texas, Arlington, TX
WP 730 Coupling Free-Flow Electrophoresis with Desorption
Electrospray Ionization Mass Spectrometry (DESI-MS)
for Proteomic Analysis; Sarah Anciaux; Michael Bowser;
University of Minnesota, Minneapolis, MN
WP 731 Using Desorption Electrospray Ionization Mass
Spectrometry to Detect Specific Decomposition
Pathways of Ruthenium Catalysts during C-H Activation
Reactions; Cornelia Flender; Jennifer Roizen; Eric McNeill;
Justin Du Bois; Richard Zare; Stanford University, Stanford,
CA
WP 732 Detection of Explosive Molecular Adduct Ions with
Flowing Atmospheric-Pressure Afterglow Mass
Spectrometry; G. Asher Newsome1, 2; Lauryn E. DeGreeff2,
3
; Christopher J. Katilie1, 2; Kevin J. Johnson2; 1Nova
Research, Inc., Alexandria, VA; 2U.S. Naval Research
Laboratory, Washington, DC; 3National Research Council,
Washington, DC
WP 733 Analysis of Organic Light-Emitting Diodes (OLED)
Using an Atmospheric Pressure MALDI Source Coupled
to an Orbitrap-based Mass Spectrometer; Maxie Kohler1;
Kerstin Strupat2; Thorsten Umbach1; Heike Klesper1; Klaus
Meerholz1; 1University of Cologne, Cologne, Germany;
2
Thermo Fisher Scientific, Bremen, Germany
WP 734 ESI and MALDI Sample Introduction, Preparation
Unified By Electric Induction? Drew Sauter 1; Andrew
Sauter III1; Alexander Scheeline2; Andrew Grange3; Gary
Groenewold4; 1Nanoliter, LLC, Henderson, NV; 2University of
Illinois, Urbana, IL; 3USEPA, Las Vegas, NV; 4Idaho National
Lab, Idaho Falls, ID
Ion Mobility Fundamentals, 735 – 754
WP 735 Separation of Isomeric Nitro-PAH by TWIM-MS Using
Polarizable Drift Gases: The Effects of Ion Charge
Distribution on the Resolution; Maíra Fasciotti1; Caroline
Franco2; Gabriel Heerdt3; Annibal D. Perreita Netto2;
Nelson H. Morgon3; Romeu J. Daroda1; Marcos N. Eberlin4;
1
INMETRO, Rio de Janeiro, BR; 2Federal Fluminense
University, Niterói, Brazil; 3UNICAMP, Campinas, BR;
4
ThoMSon Mass Spectrometry Laboratory, Campinas, BR
WP 736 Structure of Polyphenol Clusters – An Ion Mobility
Study; Frédéric Poussigue1, 2; Arnaud Vernier1, 3; Jérôme
Lemoine1, 2; Philippe Dugourd1, 3; Fabien Chirot1, 2;
1
Université Lyon 1, Villeurbanne, France; 2CNRS, UMR
5280 ISA, Villeurbanne, France; 3CNRS, UMR 5306 ILM,
Villeurbanne, France
WP 737 Ion Mobility Mass Spectrometry of Small Molecule,
Polymer, and Native Protein Complex Anions; Samuel
J. Allen; Alicia M. Schwartz; Matthew F. Bush; University of
Washington, Seattle, WA

61ST ASMS CONFERENCE ON MASS SPECTROMETRY

WEDNESDAY POSTERS

WP 738 Travelling Wave Ion Mobility Calibration with
Phosphoric Acid Clusters; Helene Lavanant; Vincent
Tognetti; Carlos Afonso; Normandie Univ UMR 6014, FR
3038; Univ Rouen; CNRS, Mont St Aignan, France
WP 739 Ion Mobility-Mass Spectrometry of Iodide Salt Cluster
Ions in Air and Comparison to Density Functional
Theory Structural Predictions; Chris Hogan; Hui Ouyang;
Carlos Larriba-Andaluz; Derek Oberreit; University of
Minnesota, Minneapolis, Minnesota
WP 740 Determination of Collision Cross Sections for Ion
Standards using a New Commercial Drift Tube for IMMS using Nitrogen Bath Gas; Peter Backlund1; Stephanie
Cologna1; Christopher Crutchfield1; Christian Klein2; Ruwan
Kurulugama2; Ed Darland2; Alex Mordehai2; Alfred L. Yergey
1 1
; NIH, Bethesda, MD; 2Agilent Technologies, Santa Clara,
CA
WP 741 Towards Predicting Differential Mobility Based Upon
Molecular Structure; Brad Schneider1; Erkinjon Nazarov2;
Goran Ristic1; Thomas Covey1; 1AB SCIEX, Concord,
Canada; 2Draper Laboratories, Tampa, FL
WP 742 Calculations of Ion Mobilities for Biological
Macromolecules Using the Electronic Surface
Representation; Yuri Alexeev1; Dmitri G. Fedorov2;
Alexandre A. Shvartsburg 3; 1Argonne National Laboratory,
Argonne, IL; 2Nanosystem Research Institute, Tsukuba,
Japan; 3Pacific Northwest National Laboratory, Richland,
WA
WP 743 A New Paradigm for Electrospray Ion Mobility-Mass
Spectrometry of Proteins; Kent Gillig; Yu-Ling Chang;
Chung-Hsuan Chen; Academia Sinica, Taipei, Taiwan
WP 744 Multiplexed High Pressure Ion Mobility-TOFMS: High
Resolution, Sensitivity and Structural Information in
One Package; Richard Knochenmuss; Stephan Graf; Katrin
Fuhrer; Marc Gonin; Tofwerk, Seftigen, Switzerland
WP 745 Selected Accumulation Ion Mobility Spectrometry
(SAIMS) Hyphenated with a Fourier Transform Mass
Spectrometer (FTMS); Melvin A. Park; Desmond Kaplan;
Mark Ridgeway; Bruker Daltonics, Inc., Billerica, MA
WP 746 Maximizing Gas Phase Peak Capacity while Minimizing
Analysis Time through DIMS/TIMS/MS; Mark Ridgeway;
Desmond Kaplan; Kevin Dixon; Melvin Park; Bruker
Daltonic, Billerica, MA
WP 747 Development of a Spatially Multiplexed 8-Channel Ion
Mobility-Mass Spectrometer: Vacuum System, Ion
Source, and Interfacing Ion Funnel Arrays; Katrina
L. Leaptrot; Jody C. May; John A. McLean; Vanderbilt
University, Nashville, TN
WP 748 Electrical Mobilities of Near-Spherical, Multiply-Charged
Ionic Liquid Nanodrops in Air: Influence of Drift-Gas
Temperature and Ion–Induced Dipole Interactions;
Juan Fernández García; Juan Fernández de la Mora; Yale
University, New Haven, CT
WP 749 Measuring Reduced Ion Mobilities of
Tetraalkylammonium Cations in Intermediate Field
Using a Double Slit Differential Mobility Analyzer (DMA);
John van Nostrand; Udo Verkerk; K. W. Michael Siu; York
University - CRMS, Toronto, Canada
WP 750 The Inability of Hard Sphere Specular Scattering to
Predict Ion Mobility in Diatomic Gases in the 5-100kDa
Range; Carlos Larriba Andaluz; Christopher Hogan;
University of Minnesota, Minneapolis, MN

WP 751 Distance Geometry: A Time Efficient Approach for
Sampling Conformational Space in Support of Ion
Mobility Structural Mass Spectrometry; Sarah M. Stow1;
Cody R. Goodwin1; Michal Kliman1; Ruwan Kurulugama2;
Ed Darland2; Brian O. Bachmann1; Terry P. Lybrand1; John
A. McLean 1; 1Department of Chemistry at Vanderbilt
University, Nashville, TN; 2Agilent Technologies Inc., Santa
Clara, CA
WP 752 Imaging the Ion Beam Inside a Drift Tube Ion Mobility
Spectrometer Using a Pixelated Detector; Harikrishnan
Sukumar1; Stephen Davila1; John Stone2; Gary Eiceman1;
1
New Mexico State University, Las Cruces, NM; 2Queen’s
University, Kingston, Ontario, Canada
WP 753 Development of a New Ion Mobility-Quadrupole Timeof-Flight Mass Spectrometer for High-Resolution
and High-Throughput Biological Sample Analyses;
Ruwan Kurulugama1; Alexander Mordehai1; Nathan
Sanders1; Christian Klein1; Yehia Ibrahim2; Erin Baker2;
Richard Smith2; George Stafford1; John Fjeldsted1; 1Agilent
Technologies, Santa Clara, CA; 2Pacific Northwest National
Laboratory, Richland, WA
WP 754 Reduced Ion Mobilities: A Need for Parameterization of
Chemical Analyte Properties? Philipp Cochems1; Walter
Wissdorf2; Yessica Brachthaeuser2; Christine Polaczek2;
Thorsten Benter2; Stefan Zimmermann1; 1Leibniz University
Hannover, Hannover, Germany; 2University of Wuppertal,
Wuppertal, Germany

61ST ASMS CONFERENCE ON MASS SPECTROMETRY						

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GENERAL
INFORMATION
THURSDAY
POSTERS

7:30-8:00 am.............................................. Set up all Thursday posters
10:30 am-1:00 pm................................Odd-numbered posters present
12:00-2:30 pm.................................... Even-numbered posters present
2:30-3:00 pm........................................... Remove all Thursday posters
Ion Mobility – FAIMS.................................................................001-021
Imaging MS: Large Molecules...................................................022-025
Imaging MS: Quantitative Analysis............................................026-030
Imaging MS: Method Developoment II......................................031-051
Imaging MS: Instrumentation....................................................052-072
Instrumentation: General...........................................................073-107
LC-MS Instrumentation.............................................................108-120
LC-MS Sample Preparation (Proteins & Peptides)...................121-139
Advances in Sample Preparation Methods for Improved
Protein Identification and Quantification............................140-169
High Throughput Analysis/Robotics...........................................170-185
GCMS: Instrumentation & Applications.....................................186-214
High Mass Accuracy/High Performance MS: Instrumentation...215-229
High Mass Accuracy/High Performance Applications................230-249
Peptides: General......................................................................250-262
Peptidomics...............................................................................263-271
Ion Mobility – FAIMS, 001 -021
ThP 001 Parameters Characterization and Optimization in
Differential Mobility Spectrometer Relative to Uses of
LDTD Ion Source; Sarah Demers1; Réal Paquin1; Gregory
Blachon2; Pierre Picard2; Serge Auger2; 1Université Laval,
Quebec City, Canada; 2Phytronix Technologies, Quebec
City, Canada
ThP 002 Performance Characterization of a Differential Ion
Mobility Spectrometer Operated in Laminarized LowPressure Subsonic Flows; Dimitris Papanastasiou1;
Ioannis Orfanopoulos1; Diamantis Kounadis1; Alexander
Lekkas1; Ioannis Nikolos2; Roger Giles3; Andrew Entwistle3;
Emmanuel Raptakis1; 1Fasmatech, Athens, GR; 2Technical
University of Crete, Chania, GR; 3Shimadzu Research
Laboratory, Manchester, UK
ThP 003 Application of Differential Ion Mobility Technology to
Improve the Quantitation of Small Molecules by LC-MS/
MS; Richard Grater; Naveed Shaik; Ellen Rohde; Lawrence
Gan; BiogenIdec, Cambridge, MA
ThP 004 Identification of Compounds in Organic Aerosols Using
Differential Ion Mobility Spectrometry and High Mass
Accuracy Tandem Mass Spectrometry; Sandra Spencer;
Samantha Isenberg; Gary Glish; University of North
Carolina, Chapel Hill, NC
ThP 005 Investigation of Vitamin K2 Structures Using Differential
Ion Mobility Spectrometry and DFT Calculations; David
Crizer; Samantha Isenberg; Beth Marbois; Gary Glish;
University of North Carolina, Chapel Hill, NC
ThP 006 Comparison of Electrospray, Nano-electrospray,
and Low Temperature Plasma Ionization for Use
with Differential Ion Mobility Spectrometry; Brandon
Santiago; Gary Glish; University of North Carolina, Chapel
Hill, NC
ThP 007 Differential Mobility Separation Pre-filtration on an
Agilent ESI Mass Spectrometer; Theresa Evans-Nguyen;
Spiros Manolakos; Francy Sinatra; James Alberti; Kevin
Hufford; Draper Laboratory, Tampa, FL
ThP 008 Improving the LC-MS/MS Selectivity of
Hexabromocyclododecane Diastereomers with
Differential Mobility Spectrometry; Changqing Lin1;
YI Pan1; Chen Zheng2; Yongming Xie2; 1Shanghai Putuo
Environmental Monitoring Station, Shanghai, China;
2
Shanghai AB Sciex Analytical Instrument Trading Co,
Shanghai, China

PAGE 152					

Peptides: Sequence Analysis....................................................272-278
Phosphopeptides: Quantitative Analysis...................................279-306
Protein: PTM II..........................................................................307-328
Glycoproteins II.........................................................................329-357
Carbohydrates II........................................................................358-383
Biomarker Quantitation: Glycans, Lipids & Metabolites............384-410
Biomarker Discovery: Cancer and Neuroscience...................... 411-442
Proteomics: Clinical Applications...............................................443-476
Proteins: Membrane..................................................................477-485
Microorganisms: Identification and Characterization.................486-519
Homeland Security....................................................................520-527
Food Safety - Pesticides...........................................................528-558
Lipids: Profile Analysis...............................................................559-591
Small Molecules: Quantitative Analysis IV................................592-619
Ambient Ionization: Fundamentals............................................620-633
Ionization Mechanisms..............................................................634-651
Energy: Biofuels........................................................................652-664
Informatics: Pathway Analysis...................................................665-668
Informatics: Peptide Identification/Characterization II...............669-693
Ion Spectroscopy.......................................................................694-710
Ion Structure / Energetics.......................................................... 711-727
ThP 009 A Sensitive and Selective LC-Differential MobilityMass Spectrometric Analysis of Allopregnanolone
and Its Isomers in Human Plasma; Wen Jin1; Michael
Jarvis1; Michal Weinstock1; Margaret Altemus2; 1AB SCIEX,
Concord, Canada; 2New York Presbyterian Hospital and
Cornell University, New York, NY
ThP 010 Improving Protein and Peptide Detection by Combining
Differential Mobility and Atmospheric Proton Transfer
Reaction; J.C. Yves Leblanc; J. Larry Campbell; Igor
Chernushevich; Stephen Tate; AB SCIEX, Concord, On,
Canada
ThP 011 Improving Speed and Selectivity of Targeted Peptide
Quantification Using FAIMS; Susan E. Abbatiello1;
Lindsay Pino1; Michael Belford2; Eric Kuhn1; Nathan Yates3;
Steven A. Carr1; 1The Broad Institute of Harvard and MIT,
Cambridge, MA; 2Thermo Fisher Scientific, San Jose, CA;
3
University of Pittsburgh, Pittsburgh, PA
ThP 012 High-Throughput Analysis of Drugs in Biological
Matrices with Enhanced Selectivity for Quantitation
Using FAIMS SPE/MS/MS; Michael Ugarov 1; Yuqin Dai1;
Kari Schlicht2; Vaughn Miller2; 1Agilent Technologies, Santa
Clara, CA; 2Agilent Technologies, Wakefield, MA
ThP 013 Faster Reaction Monitoring of Reductive Amination
Using Chip-Based FAIMS-MS; Lauren Brown1; Celine
Laine1; Danielle Toutoungi1; Shelly Li2; Gilles Goetz2;
Guilong Cheng2; 1Owlstone Ltd, Cambridge, UK; 2Pfizer
Global R&D, Groton, CT
ThP 014 Separation of Isomers Using Modifier Gases on Chipbased FAIMS / Triple Quadrupole MS; Christopher
Beekman1; Timothy J. Garrett1; Michael Ugarov2;
George Stafford2; Richard A. Yost1; 1University of Florida,
Gainesville, FL; 2Agilent Technologies, Santa Clara, CA
ThP 015 Electrospray/ High-field Asymmetric Waveform Ion
Mobility Spectrometry/ Mass Spectrometry of Transition
Metals: Potential for Environmental and Nuclear
Applications; Jared Boock; Richard Yost; University of
Florida, Gainesville, FL
ThP 016 Using Gas Additives to Improve Signal Intensity and
Selectivity of a Cylindrical FAIMS Device; Randy W.
Purves1; Allison R. Ozog1; Stephen J. Ambrose1; Michael
Belford2; Satendra Prasad2; Jean-Jacques Dunyach2;
1
National Research Council, Saskatoon, Canada; 2Thermo
Fisher, San Jose, CA

61ST ASMS CONFERENCE ON MASS SPECTROMETRY

THURSDAY POSTERS

ThP 017 Ion Mobility Separations of Protein Conformers with
Resolving Power up to 400 Using Hydrogen-Rich Gas
Buffers; Alexandre A. Shvartsburg; Richard D. Smith;
Pacific Northwest National Laboratory, Richland, WA
ThP 018 Effect of Electrode Geometry on FAIMS Gas Flow With
Regard to Sensitivity and Resolution; Michael Belford;
Satendra Prasad; Jean-Jacques Dunyach; Thermo Fisher
Scientific, San Jose, CA
ThP 019 Exploring the Effects of Carrier Gas Modifiers Using
Chip-Based Field Asymmetric Waveform Ion Mobility
Spectrometry Combined with Mass Spectrometry;
Robert Smith1; Danielle Toutoungi2; James Reynolds1;
Ashley Sage3; Billy Boyle2; Colin Creaser1; 1Loughborough
University, Loughborough, UK; 2Owlstone Ltd, Cambridge,
UK; 3Agilent Technologies, Stockport, UK
ThP 020 Identification of Amino-Sulfonamide Isomers
Using Chip-Based FAIMS-MS Approaches; Danielle
Toutoungi1; Lauren Brown1; Billy Boyle1; Samantha J
Barry2; Jean-Claude Wolff2; 1Owlstone Ltd, Cambridge, UK;
2
GlaxoSmithKline, Stevenage, UK
ThP 021 Analysis of Intact Protein Ions by Chip-Based-FAIMSMS; Lauren Brown1; Danielle Toutoungi1; Billy Boyle1; Colin
Creaser2; 1Owlstone Ltd., Cambridge, UK; 2Loughborough
University, Loughborough, UK
Imaging MS: Large Molecules, 022 – 025
ThP 022 DESI Detection of Surface Proteins with MS Imaging
and MVA Analysis; Wei Rao; Adam Celiz; David Scurr;
Morgan Alexander; David Barrett; University of Nottingham,
Nottingham, UK
ThP 023 Quantitation of Peptides by MALDI Imaging Using
Labeled Peptide; Guillaume Hochart; David Bonnel;
Gregory Hamm; Raphael Legouffe; Fabien Pamelard;
Jonathan Stauber; ImaBiotech, MS Imaging Department,
Lille, France
ThP 024 Imaging of Nanoparticle Biodistributions in vivo Using
Laser Desorption/Ionization Mass Spectrometry; Bo Yan;
Sung Tae Kim; Chang Soo Kim; Krishnendu Saha; Daniel F.
Moyano; Vincent M. Rotello*; Richard W. Vachet*; University
of Massachusetts, Amherst, MA
ThP 025 MALDI Imaging and In Source Decay Indentification of
Glioma Biomarkers up to 80kDa; Rima Ait-Belkacem1;
Caroline Berenguer1; Claude Villard1; Sega Ndiaye1;
L’Houcine Ouafik1; Dominique Figarella-Branger1; Olivier
Chinot2; Daniel Lafitte1; 1AIX Marseille Universite, Marseille,
France; 2Assistance publique hopitaux de Marseille,
Marseille, France
Imaging MS: Quantitative Analysis, 026 – 030
ThP 026 Grid Method: A Novel Workflow for Dissection and
LC-MS/MS Analysis to Study Ocular Drug Distribution;
Josh Rowe; Julie Whitcomb; Chris Huntington; Jinsong Ni;
Allergan, Inc., Irvine, CA
ThP 027 Quantitative Bioimaging of Drugs in Thin Tissue
Sections; Olga Reifschneider1; Christoph A. Wehe1;
Michael Sperling1, 2; Uwe Karst1; 1University of Münster,
Münster, Germany; 2European Virtual Institute for Speciation
Analysis, Münster, Germany
ThP 028 A Quantitative Study of Peptide Release by Mass
Spectrometry Imaging of Microfluidic Microchannels;
Callie Croushore1, 2; Stanislav Rubakhin1, 2; Jonathan
Sweedler1, 2; 1Beckman Institute, UIUC, Urbana, IL;
2
Department of Chemistry, UIUC, Urbana, IL
ThP 029 Quantitative DESI& MALDI Imaging Applied on
Ophthalmic Related Compound Distribution Study;
Raphael Legouffe1; Joseph H Kennedy2; Gregory Hamm1;

Fabien Pamelard1; Justin Wiseman2; Jonathan Stauber1;
1
ImaBiotech, MS Imaging Department, Lille, France;
2
Prosolia, Inc., Indianapolis, IN
ThP 030 Spatially-Aware Feature-Sparse Clustering for Mass
Spectrometry Imaging; Kyle Bemis1; Livia Eberlin2;
Christina Ferreira1; R. Graham Cooks1; Olga Vitek1; 1Purdue
University, West Lafayette, IN; 2Stanford University, Palo
Alto, CA
Imaging MS: Method Developoment II, 031 – 051
ThP 031 MALDI Imaging MS of Intact Pollen Grains and Pollen
Mixtures; Steffen M. Weidner1; Bernd Enthaler2; Benjamin
C. Krause3; 1Federal Inst.for Materials Research & Testing,
1.3, Berlin, Germany; 2University of Hamburg, Institute of
Food Chemistry, Hamburg, Germany; 3Humboldt-University,
Physical Chemistry, Berlin, Germany
ThP 032 Development of the Technique for Visualizing the Plant
Metabolites Distribution Using MALDI-MS Imaging;
Junya Nakamura1; Maiko Kaku2; Yoshinori Fujimura2;
Katsutoshi Takahashi3; Daisuke Miura2; Hiroyuki Wariishi4;
1
Grad. Sch. Biores. Bioenviron. Sci., Kyushu Univ., Fukuoka,
Japan; 2ICMRN, Kyushu Univ., Fukuoka, Japan; 3AIST,
Tokyo, Japan; 4Fac. Arts and Sci., Kyushu Univ., Fukuoka,
Japan
ThP 033 Pre-coated Targets with Matrix and Trypsin for in-situ
Protein Digestion in Imaging Mass Spectrometry; Faizan
Zubair; Junhai Yang; Jeremy L. Norris; Richard M. Caprioli;
Paul E. Laibinis; Vanderbilt University, Nashville, TN
ThP 034 The Challenge of On-Tissue Digestion for MALDI-IMS a
Comparison of Different Protocols to Improve Imaging
Experiments; Hanna Diehl1; Julian Elm1; Judith Baronner1;
Dennis Trede2; Herbert Thiele2; Helmut E. Meyer1; Corinna
Henkel1; 1Medizinisches Proteom-Center, Ruhr-University,
Bochum, Germany; 2Steinbeis Innovation Center SCiLS,
Bremen, Germany
ThP 035 High Resolution MALDI Imaging at 25 µm Pixel Size for
Peptides after On-Tissue Digestion; Andreas Roempp;
Katharina Huber; Yvonne Schober; Thorsten Schramm;
Bernhard Spengler; Justus Liebig University, Giessen,
Germany
ThP 036 Acquisition and Analysis of 3D MALDI Imaging Data
Sets; Shannon Cornett1; Janina Oetjen2; Dennis Trede3,
4
; Michaela Aichler5; Jan Strehlow6; Stefan Heldmann7;
Judith Berger7; Michael Gottschalk8; Klaus Steinhorst3;
Jan Hendrik Kobarg3, 4; Stefan Wirtz6; Stefan Schiffler3, 4;
Herbert Thiele3; Axel Walch5; Peter Maass3, 4; Theodore
Alexandrov3, 4; Detlev Suckau9; Michael Becker9; 1Bruker
Daltonics, Billerica, MA; 2University of Bremen, MALDI
Imaging Lab, Bremen, Germany; 3Steinbeis Innovation
Center SCiLS, Bremen, Germany; 4Univ. Bremen, Center
for Industrial Mathematics, Bremen, Germany; 5HelmholtzZentrum München, Dept. of Pathology, Munich, Germany;
6
Fraunhofer MEVIS Inst. for Medical Image Computing,
Bremen, Germany; 7Fraunhofer MEVIS Project Group
Image Registration, Lübeck, Germany; 8Bruker Biospin
MRI GmbH, Ettlingen, Germany; 9Bruker Daltonik GmbH,
Bremen, Germany
ThP 037 Polyhydroxyflavonoids as a Novel Family of Matrices
for MALDI Tissue Imaging; Xiaodong Wang1; Jun Han1;
Albert Chou1; Juncong Yang1; Jingxi Pan1; Christoph
Borchers1, 2; 1University of Victoria-Genome BC Proteomics
Centre, Victoria, Canada; 2Dept of Biochemistry and
Microbiology, U Victoria, Victoria, Canada
ThP 038 2D Graphene as a MALDI IMS Matrix for Brain Tissue;
William Friesen; Brian Schultz; Joe Steet; Sarbajit Banerjee;
Troy Wood; SUNY at Buffalo, Buffalo, NY

61ST ASMS CONFERENCE ON MASS SPECTROMETRY						

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GENERAL
INFORMATION
THURSDAY
POSTERS

ThP 039 Imaging MALDI Mass Spectrometry in Microscope
Mode with Infrared Lasers – Breaking the Diffraction
Limit on Biological Samples; Jens Soltwisch; Julia
Jungmann; Donald F. Smith; Andras Kiss; Shane Ellis; Ron
Heeren; FOM Institute AMOLF, Amsterdam, the Netherlands
ThP 040 Correlated Imaging Mass Spectrometry and Raman
Spectroscopy for Oncology and Drug Resistance;
Dorothy Ahlf; Eric Weaver; Rachel Masyuko; Haohang Li;
Paul Bohn; Amanda Hummon; University of Notre Dame,
Notre Dame, IN
ThP 041 Silver Assisted LDI for High Spatial Resolution Imaging
MS of Olefins from Thin Tissue Sections; Martin
Dufresne1; Aurelien Thomas1; Julien Breault-Turcot2; JeanFrançois Masson2; Pierre Chaurand1; 1Pierre Chaurand
Group, Montréal, Canada; 2Jean-François Masson,
Montreal, Canada
ThP 042 Novel Bioinformatics Platform for Interactive
Interrogation of DESI-mass Spectrometry Imaging
Datasets in Clinical Research Settings; Kirill Veselkov1;
Reza Mirnezami1; Nicole Strittmatter1; James Kinross1;
Robert Goldin1; Abigail Speller1; Tigran Abramov2; Ara
Darzi1; Zoltan Takats1; 1Imperial College London, London,
UK; 2Sevastopol National Technical University, Streletskaya
Bay, Crimea, Ukraine
ThP 043 Characterizing and Imaging Glycerophosphocholine
Lipids by Lithiation and C60-SIMS; Anita Durairaj; Lauren
M. Jackson; Nicholas Winograd; The Pennsylvania State
University, University Park, PA
ThP 044 Blotting Assisted by Heating and Solvent Extraction for
DESI-MS Imaging of Biological Tissues; Elaine Cristina
Cabral1; Mario Francesco Mirabelli2; Consuelo J. Perez1;
Demian Rocha Ifa1; 1York University, Toronto, Canada;
2
University of Calabria, Cosenza, Italy
ThP 045 The Evolution of 3D Biological Imaging to FIB-TOF
Tomography; Gregory L Fisher; John S Hammond; Scott R
Bryan; Physical Electronics, Chanhassen, MN
ThP 046 High-Sensitivity Bio-Molecular Imaging and Protein
Identification with a C60 Ion Microprobe; John
Hammond1; Gregory Fisher1; Mark Jansen2; Luke
MacAleese2; Ron Heeren2; 1Physical Electronics,
Chanhassen, MN; 2FOM/AMOLF, Amsterdam, The
Netherlands
ThP 047 Molecular Imaging and Analysis of Drugs by Laser
Ablation Atmospheric Pressure Chemical Ionization
Mass Spectrometry (LA/APCI-MS); Christina Herdering;
Christoph A. Wehe; Olga Reifschneider; Michael Sperling;
Uwe Karst; University of Münster, Münster, Germany
ThP 048 Visualization of Lipid Species on Human Retina Using
Mass Microscope; Takahiro Hayasaka1; Naoko GotoInoue2; Noritaka Masaki1; Mitsutoshi Setou1; 1Hamamatsu
University School of Medicine, Hamamatsu, Japan; 2Tokyo
Metropolitan University, Hachioji, Japan
ThP 049 Mass Spectrometry Analysis and Imaging of Lipids
and Proteins in Human Liver via MALDI and Liquid
Extraction Surface Analysis; Joscelyn Sarsby; Rian L.
Griffiths; Rory Steven; Alan Race; Emily Guggenheim; Trish
Lalor; Helen J. Cooper; Josephine Bunch; University of
Birmingham, Birmingham, UK
ThP 050 Microscope Mode Mass Spectrometry – An Approach
for Improved Imaging over Multiple Mass Ranges;
Benjamin Winter; Edward Halford; Simon-John King;
Alexandra Lauer; Claire Vallance; Mark Brouard; University
of Oxford, Oxford, UK
ThP 051 Laserspray Ionization on an Orbitrap Exactive :
Performing Imaging Mass Spectrometry at Ultra High
Mass Resolution; Andrew F. Harron; Khoa Hoang; Charles
McEwen; USP, Philadelphia, PA

PAGE 154					

Imaging MS: Instrumentation, 052 – 072
ThP 052 Robotic Plasma Probe Ambient Ionization Mass
Spectrometry Imaging of Non-Planar Surfaces; Ezequiel
M. Morzan1, 2; Rachel V. Bennett2; Facundo M. Fernandez2;
1
Universidad de Buenos Aires, Buenos Aires, Argentina;
2
Georgia Institute of Technology, Atlanta, GA
ThP 053 Near-Field Laser Ablation for Mass Spectrometry of
Single Cells; Yonathan Merid; Kermit K. Murray; Louisiana
State University, Baton Rouge, LA
ThP 054 Rapid Imaging of Unprocessed Chicken Bone Marrow
by LAESI-MS with T-Wave Ion Mobility Separation Using
a Synapt G2-S; Emmanuelle Claude1; Michel W.F Nielen2,
3
; Brent R. Reschke4; Hilary Major1; 1Waters Corporation,
Manchester, UK; 2RIKILT, Wageningen, The Netherlands;
3
Wageningen University, Lab of Organic Chemistry,
Wageningen, The Netherlands; 4Protea Biosciences,
Morgantown, US
ThP 055 Mass Imaging Analysis of Oligonucleotides and
Peptides Microarrays by Using Microscopic MALDI
Imaging Mass Spectrometry; Joo Yeon Oh1; Sohee Yoon1;
Jeong Hee Moon2; Sang Yun Han1; Tae Geol Lee1; 1Korea
Res. Inst. of Standards and Science, Daejeon, South
Korea; 2Korea Res. Inst. of Bioscience and Biotechnology,
DaeJeon, South Korea
ThP 056 Fast Survey Scan Acquisition and Multiple Detector
Utilization for Elemental Mass Spectrometric
Bioimaging; Christoph Alexander Wehe1; Olga
Reifschneider1; Ann-Christin Bülter1; Michael Kieshauer1;
Michael Sperling1, 2; Uwe Karst1; 1University of Münster,
Münster, Germany; 2European Virtual Institute for
Speciation Analysis, Münster, Germany
ThP 057 A Method For Rapid Matrix Sublimation for MALDI Lipid
Ion Imaging; Vijanaka Fernando2; Vladimir Collado1; Victor
Spicer1; Werner Ens1; 1University of Manitoba, Winnipeg,
Canada; 2The Open University of Sri Lanka, Colombo, Sri
Lanka
ThP 058 Atmospheric Pressure MALDI Imaging Mass
Spectrometry with High Spatial Resolution; Berk Oktem;
Konstantin Novoselov; Jianhua Tang; Vladimir Doroshenko;
MassTech Inc., Columbia, MD
ThP 059 The Implementation of the Time-Stamping, Multi-Hit
PImMS Sensor in Combination with a Commercially
Available Time-Of-Flight Mass Spectrometer; Edward
Halford1; Samuel Coles1; Alexandra Lauer1; Benjamin
Winter1; Jason W. L. Lee1; Mark Mills2; Steve Thompson2;
Claire Vallance1; Mark Brouard1; 1University of Oxford,
Oxford, UK; 2SAI, Manchester, UK
ThP 060 Fundamental Characterization of Infrared MatrixAssisted Laser Desorption Electrospray Ionization
(IR-MALDESI) for Mass Spectrometry Tissue Imaging
Using Ice as a Matrix; Guillaume Robichaud; Jeremy A.
Barry; David C. Muddiman; North Carolina State University,
Raleigh, NC
ThP 061 Protein and Lipid Tissue Imaging at 5 µm Spatial
Resolution, Using Commercial Bruker MALDI TOFMS
Instrument with Gaussian Laser Beam; Andre Zavalin
1
; Junhai Yang1; Andreas Haase2; Armin Holle2; Richard
Caprioli3; 1Vanderbilt University, Nashville, TN; 2Bruker
Daltonik GmbH, Bremen, Germany; 3Vanderbilt University
School of Medicine, Nashville, TN
ThP 062 Differential Mobility-Enhanced Ambient Mass
Spectrometry Imaging; Chaminda M. Gamage1; Rachel
V. Bennett1; Asiri S. Galhena2; Facundo M. Fernandez1;
1
Georgia Institute of Technology, Atlanta, GA; 2The CocaCola Company, Atlanta, GA

61ST ASMS CONFERENCE ON MASS SPECTROMETRY

THURSDAY POSTERS

ThP 063 Rapid Prototyping of a Low-Temperature Plasma Mass
Imaging System (LTP-MSI) by Using Phidgets and
OpenMZxy; Mauricio Maldonado-Torres; Pedro JiménezSandoval; Robert Winkler; CINVESTAV Unidad Irapuato,
Irapuato, Mexico
ThP 064 Ion Microscopy with the Timepix Active Pixel Detector:
Ultrahigh Spatial Resolution SIMS and MALDI Analysis
of Complex Surfaces; Julia H. Jungmann1; Andras Kiss1;
Donald F. Smith1; Luke MacAleese2; Ron M. A. Heeren1;
1
FOM-Institute Amolf, Amsterdam, The Netherlands; 2Institut
Lumiere Matiere, Universite Lyon 1-CNRS, Villeurbanne
Cedex, France
ThP 065 Tissue Imaging with Scanning Probe Electrospray
Ionization; Yoichi Otsuka1; Junpei Naito1; Masafumi
Kyogaku1; Ryuichi Arakawa2; Hiroyuki Hashimoto1; 1Frontier
Research Center, Canon Inc., Tokyo, Japan; 2Kansai
University, Osaka, Japan
ThP 066 Development of New Stigmatic Imaging Mass
Spectrometer and Its Application to Metal Cation
Distribution in Fish; Jun Aoki; Hisanao Hazama; Kunio
Awazu; Michisato Toyoda; Osaka University, Osaka, Japan
ThP 067 Pushing the Limits of Secondary Ion Mass
Spectrometry by FT-ICR MS; Donald F. Smith1; Andras
Kiss1; Franklin E. Leach2; Errol W. Robinson2; Ljiljana
Paša-Tolić2; Ron M.A. Heeren1; 1FOM Institute AMOLF,
Amsterdam, Netherlands; 2Environmental Molecular
Sciences Laboratory, PNNL, Richland, WA
ThP 068 The Pixel Imaging Mass Spectrometry (PImMS) Sensor
– A Versatile High-Speed Position-Sensitive Detector for
Imaging Mass Spectrometry; Jason Lee1; Andrew Clark2;
Jamie Crooks2; Iain Sedgwick2; Jaya John John1; James
Bull1; Edward Wilman1; Laura Hill1; Andrei Nomerotski1;
Renato Turchetta2; Richard Nickerson1; Mark Brouard1;
Claire Vallance1; 1University of Oxford, Oxford, UK;
2
Rutherford Appleton Laboratory, Harwell, UK
ThP 069 Imaging of Biological Systems Using Laser Ablation
and a “Flying Droplet” Interface for Analyte Capture;
Jonathan Brauer; Jan Sunner; University of Oklahoma,
Norman, OK
ThP 070 Laser Ablation-Based Bioimaging with Simultaneous
Elemental and Molecular MS: Towards Spatially
Resolved Speciation Analysis; Uwe Karst; Christina
Herdering; Christoph A. Wehe; Olga Reifschneider;
Franziska Blaske; Ann-Christin Bülter; Michael Sperling;
University of Münster, Münster, Germany
ThP 071 Variable Magnification Mass Microscope Image of Multimode Mass Chemical Microscopic Molecular Imaging
System; Sohee Yoon1; Jeong Hee Moon2; Joo Yeon Oh1;
Tae Geol Lee1; 1KRISS, Daejeon, South Korea; 2KRIBB,
Daejeon, South Korea
ThP 072 Infrared Laser Ablation for Electrospray Ionization
Tissue Imaging; Sung-Gun Park; Kermit K. Murray;
Louisiana State University, Baton Rouge, Louisiana
Instrumentation: General, 073 – 107
ThP 073 3D Simulation of Quadrupole Mass Filter Performance
with Realistic Ion Input Conditions; David Langridge;
Waters, Manchester, UK
ThP 074 Simulation of Resonant Excitation in Quadrupole Linear
Ion Traps Using a High Accuracy FDM Field Solver;
Matthew Gill; Roger Giles; Shimadzu Research Laboratory
(Europe), Manchester, UK
ThP 075 The Effective Potential of a Linear Quadrupole Ion Trap
Calculated from Ion Displacements Caused by Applied
Dipole DC; Cong Gao; Donald Douglas; University of British
Columbia, Vancouver, Canada

ThP 076 Design and Performance of Quadrupole Mass Filter
Operating in Stability Zones 1 and 3; Sarfaraz Uddin
Ahmed Hashmi Syed; Simon Maher; Thomas J Hogan;
Mariya Juno Antony Joseph; Stephen Taylor; University of
Liverpool, Liverpool, UK
ThP 077 Mitigation of High Pressure Effects in Miniature Toroidal
Ion Trap for Improved Quantitative Performance; Steve
Lammert 1; Ed Lee1; Joe Oliphant1; Jeff Jones1; Randy
Waite1; Rich Prunier2; Steve Ritzau2; 1Torion Technologies,
Inc, American Fork, UT; 2Photonis, USA, Sturbridge, MA
ThP 078 Electro-Hydrodynamic Simulations for Mass
Spectrometers in Transitional Flow Regime; Xiaoyu
Zhou; Ouyang Zheng; Biomedical Engineering School,
Purdue University, West Lafayette, IN
ThP 079 Ion Tracing in Gas Dynamic Flow Fields: A Case Study
on the Ion Funnel; Athanasios Zacharos1; Alexander
Lekkas1; Michael Sudakov1; Dimitris Papanastasiou1;
Diamantis Kounadis1; Ioannis Nikolos2; Emmanuel
Raptakis1; 1Fasmatech, Athens, Greece; 2Technical
University of Crete, Chania, GR
ThP 080 Ion Carpets for Large Mass Ions; Staci Anthony; Deven
Shinholt; Martin Jarrold; Indiana University, Bloomington, IN
ThP 081 New Ion Source, Ion Transfer, and Ion Accumulation
for a 9.4 Tesla FT-ICR Mass Spectrometer; Yu Chen 1;
Franklin E. Leach III2; John P Quinn1; Nathan K Kaiser1;
Gregory T. Blakney1; Tong Chen3; Steven C Beu1; Yehia
Ibrahim2; Randolph Norheim2; Gordon Anderson2; Richard
D Smith2; Christopher L Hendrickson1, 3; Alan G Marshall1,
3 1
; National High Magnetic Field Laboratory, Tallahassee,
FL; 2Pacific Northwest National Laboratory, Richland, WA;
3
Florida State University, Tallahassee, FL
ThP 082 Observation of Fine Structure in Isotopic Peak
Distributions in 4.7T Magnet FT-ICR Mass Spectra
Obtained by Using Dynamically Harmonized
Cell; Konstantin Nagornov1; Gleb Vladimirov1; Yury
Kostyukevich1, 4; Igor Popov2, 4; Eugene Nikolaev1, 3; 1Institute
for Energy Problems of Chemical Physics, Moscow, Russia;
2
Emanuel Institute of Biochemical Physics, Moscow, Russia;
3
Orekhovich Institute of Biomedical Chemistry, Moscow,
Russia; 4Moscow Institute of Physics and Technology,
Moscow, Russia
ThP 083 Multiplexed Electrospray System for the Chemical
Patterning of Surfaces Under Ambient Conditions;
Zane Baird; Michael Wleklinski; Hsu-Chen Hsu; R. Graham
Cooks; Purdue University, West Lafayette, IN
ThP 084 Evaluation of Sensitivity Improvements of a Tandem
Mass Analyzer; Satendra Prasad1; Eloy Wouters1; JeanJacques Dunyach1; Alexander Makarov2; 1Thermo Fisher
Scientific, San Jose, CA; 2Thermo Fisher Scientific (Bremen)
GmbH, Bremen, Germany
ThP 085 Effect of Electroosmotic Flow on the Function of LiquidJunction Electrospray Interface between Capillary
Electrophoresis and Mass Spectrometry; Karel Kleparnik;
Jaroslav Luksch; Anna Tarantova; Frantisek Foret; Institute
of Analytical Chemistry ASCR, Brno, Czech Republic
ThP 086 Optimization of Electrospray Ionization (ESI)
Parameters Using Design of Experiment in LC-ESI-TOF
Analysis of Analytes in Various Matrices; Jana Rousova;
Richard Cochran; Nagaraju Dongari; Paige Kuplic; Kari
Kusler; Kacie Lundgren; Eric Nelson; Alena Kubatova;
University of North Dakota, Grand Forks, ND
ThP 087 Probing the High Mass Transmission Characteristics
of a Conjoined Ion Guide Enabled Quadrupole / Ion
Mobility / Time-of Flight Instrument; Kevin Giles; Jason
Wildgoose; Jonathan Williams; Martin De Cecco; Waters
Corporation, Manchester, UK

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POSTERS

ThP 088 Improvement of MALDI-TOFMS Ion Source for Higher
Resolving Power over Wider Mass Range; Kei Kodera;
Sadanori Sekiya; Makoto Hazama; Shinichi Iwamoto; Koichi
Tanaka; Shimadzu Corporation, Kyoto, Japan
ThP 089 Novel Acquisition Strategies for TOF and IMS-TOF Mass
Spectrometers; Keith Richardson1; Jason Wildgoose1;
Martin Green1; Stephen Platt1; Martin Palmer1; Mark
Wrona2; Asish Chakraborty2; Arkadiusz Grzyb3; 1Waters
Corporation, Manchester, UK; 2Waters Corporation, Milford,
MA; 3Inquiry Software, Bialogard, Poland
ThP 090 Preliminary Tests of an ESI QqTOF Mass Spectrometer
Prototype; Vladimir Montero Collado; Victor Spicer;
Ken Standing; University of Manitoba, Dept. of Physics,
Winnipeg, Canada
ThP 091 Factorial Experimental Designs Elucidate Significant
Factors Affecting Data Acquisition on a Quadruple
Orbitrap Mass Spectrometer; Shan M. Randall1; Helene
L. Cardasis2; David C. Muddiman1; 1North Carolina State
University, Raleigh, NC; 2Thermo Fisher Scientific, San
Jose, CA
ThP 092 GPU Based Ion Cloud Dynamics Simulation in Orbitrap
with Accounting for Space Charge Shielding by the
Inner Electrode; Pavel Ryumin; Gleb Vladimirov; Eugene
Nikolaev; The Institute for Energy Problems of Chemical
Phys, Moscow, Russian Federation
ThP 093 Robustness and System-Health Study on Triple
Quadrupole Mass Spectrometers; Mary L. Blackburn;
Harald Oser; Jean-Jacques Dunyach; Philip M. Remes;
Michael W. Belford; Josh Maze; Thermo Fisher Scientific,
San Jose, CA
ThP 094 Advances in Sensitivity, Robustness, Speed, and
Dynamic Range on a Newly Developed Triple
Quadrupole Mass Spectrometer; Harald Oser; Ethan
Chan; Oleg Silivra; Joshua Maze; Satendra Prasad; JeanJacques Dunyach; Michael Belford; Eloy Wouters; Huy
Nguyen; Terry Olney; Thermo Fisher Scientific, San Jose, CA
ThP 095 Mass and Resolution Calibration Method For New
Quadrupole Mass Spectrometers; Rob Grothe; Thermo
Fisher Scientific, San Jose, CA
ThP 096 High-Speed Mass Measurement of Nanoparticle and
Virus; Huan-Chang Lin1, 2; Jung-Lee Lin1; Jia-Tsrong Jan1;
Chung-Hsuan Chen1, 2; 1GRC, Academia Sinica, Taipei,
Taiwan; 2BIME, National Taiwan University, Taipei, Taiwan
ThP 097 Quantitative Analysis of Protein Adsorption on Porous
Polymer Particles by Using Ion Trap Particle Mass
Spectrometry; Zongxiu Nie; Caiqiao Xiong; Institute of
Chemistry Chinese Academy of Sciences, Beijing, China
ThP 098 Design, Installation and Validation of a Nitrogen
Generation System in a Clinical LC-MS/MS Lab; Brett
Holmquist; Donald Walt Chandler; Esoterix, a LabCorp
Company, Calabasas Hills, CA
ThP 099 New Optimization Scheme for Ion Stalling Devices;
Byungchul Cha; Joshua Maze; Oleg Silivra; Harald Oser;
Thermo Fisher Scientific, San Jose, CA
ThP 100 Comparison of Dipolar Direct Current and Orifice
Voltage Induced Collision Induced Dissociation in a
Linear Ion Trap System; Kilyoung Kim; Cong Gao; Donald
Douglas; Univ of British Columbia, Vancouver, Canada
ThP 101 Implementation of a Multipurpose Glow Discharge
Ion Source for the Introduction of Reagent/Calibrant
Ions into a Hybrid Mass Spectrometer; Lee Earley1;
John Syka1; Christopher Mullen1; Jean-Jacques Dunyach1;
Don Hunt2; Jeffrey Shabonowitz2; Michelle English2; Philip
Compton3; 1Thermo Fisher Scientific, San Jose, CA;
2
University Of Virginia, Charlottesville, VA; 3Northwestern
University, Evanston, IL

PAGE 156					

ThP 102 An Advanced Detection System for Ion Trap Mass
and Quadrupole Mass spectrometers; Raman Mathur;
Michael Senko; Philip M. Remes; Robert A. Grothe; Jean
Jacques Dunyach; Harald Oser; Satendra Prasad; Eloy R.
Wouters; Thermo Fisher Scientific, San Jose, CA
ThP 103 Chemical Analysis of Functionalized Fullerenes and
Detection of Stable Giant Fullerenes by Extreme
Ultraviolet Laser Ablation Mass Spectrometry; G.L.
Gasper 1; I.Y. Kuznetsov1; C. Oster1; D. Carlton3; W.
Chao3; E.H. Anderson3; E.R. Bernstein1, 2; D.C. Crick1, 4;
J.J. Rocca1; C.S. Menoni1; 1NSF ERC for EUV Science,
Colorado State University, Fort Collins, CO; 2Department
of Chemistry, Colorado State University, Fort Collins, CO;
3
Lawrence Berkeley National Laboratory, Berkeley, CA;
4
CVMBS, Colorado State University, Fort Collins, CO
ThP 104 High-Pressure CIT Mass Spectrometry with a SolidState CTIA Detector; Derek W. Wolfe1; Travis M. Falconer1,
2
; Roger P. Sperline3; M. Bonner Denton3; J. Michael
Ramsey1; 1University of North Carolina, Chapel Hill, NC;
2
Forensic Chemistry Center, U.S. FDA, Cincinnati, OH;
3
University of Arizona, Tucson, AZ
ThP 105 Preparative Scale Mass Spectrometry: A Modernized
Electromagnetic Isotope Separator; Kevin Hart; Brian
Egle; W. Scott Aaron; Oak Ridge National Laboratory, Oak
Ridge, TN
ThP 106 A Mathematica 3D-Histogram for Improved Energy and
Charge State Determinations from STJ Cryodetector
MS Data; Fan Wang; Dave M. Sipe; Mark E. Bier; Carnegie
Mellon University, Pittsburgh, PA
ThP 107 Online ESI-MS Analysis of HPTLC-Separated
Compounds with a New Compact Single Quadrupole
Mass Spectrometer; Frank Porbeck2; Ines Klingelhoefer1;
Mark Allen2; Gertrud Morlock1; 1Justus-Liebig-University,
Giessen, Germany; 2Advion Ltd., Harlow, UK
LC-MS Instrumentation, 108 – 120
ThP 108 SFC-APLI-TOF(MS) - A Novel Hyphenation to
Atmospheric Pressure Laser Ionization Mass
Spectrometry; Dennis Klink1; Oliver J. Schmitz2; 1University
of Wuppertal, Wuppertal, Germany; 2University of DuisburgEssen, Essen, Germany
ThP 109 Hybrid Microfluidic Electrospray Interfacing for CE-MS;
Frantisek Foret; Jana Krenkova; Jan Partyka; Jakub Grym;
Institute of Analytical Chemistry ASCR, v.v.i., Brno, Czech
Republic
ThP 110 Development of a Novel Geometry API Source Probe
Capable of both HESI and APCI; Joshua Maze; Belford
Michael; Terry Olney; Thermo Fisher Scientific, San Jose, CA
ThP 111 Evaluating the Dynamic Range of Quantitation of a
Novel Hybrid, Q-OT-qIT Mass Spectrometer; Mark E.
Hardman; Thermo Fisher Scientific, Sunnyvale, CA
ThP 112 A Comparison of Two Different LC-MS/MS Technologies
for the Determination of Peptides in Biological Fluids;
Floriane Pailleux1, 2; Arnaud Salvador1; Francis Beaudry2;
Jérôme Lemoine1; 1Université de Lyon, Vileurbanne,
France; 2Université de Montréal, Saint-Hyacinthe, Canada
ThP 113 Electrospray Inlet Ionization (ESII): A Highly Sensitive
Ionization Technique for Liquid ChromatographyMass Spectrometry; Shubhashis Chakrabarty; Vincent S.
Pagnotti; Sarah J. Saylor; Charles N. McEwen; University of
the Sciences, Philadelphia, PA
ThP 114 Comparison between Mechnisms Occuring in Paper
Spray Ionization (PSI), Liquid Extraction Surface
Analysis (LESA) and Desorption Electrospray Ionization
(DESI); Wejdan Alsaggaf; Rob O’Brien; Chemistry
Department, Kelowna, Canada

61ST ASMS CONFERENCE ON MASS SPECTROMETRY

THURSDAY POSTERS

ThP 115 Development and Evaluation of NanoESI Coupled to a
Triple Quadrupole Massspectrometer for Quantitative
Proteomics Research; Shannon Cook1; Hideki Yamamoto2;
Tairo Ogura2; Yusuke Osaka2; Ichiro Hirano2; 1Shimadzu
Scientific Instruments, Inc., Columbia, MD; 2Shimadzu
Corp., Kyoto, Japan
ThP 116 Strategies for Structure Elucidation Using Ultrafast
Mass Spectrometry (UFMS): Using nMS2 as an
Alternative to MS3; Paul Wynne1, 2, 3; Nigel Grieves1, 2, 3;
Bruce Fraser1, 2, 3; 1Shimadzu Australasia, Sydney, Australia;
2
Shimadzu Australasia, Palmerston North, New Zealand;
3
Shimadzu Australasia, Melbourne, Australia
ThP 117 On-Chip LC Separations for Inlet Ionization Based
Mass Spectrometry Detection; Berk Oktem1; Vladimir M.
Doroshenko1; Eric L. Kendall2; Don L. DeVoe2; 1MassTech
Inc., Columbia, MD; 2University of Maryland, College Park,
MD
ThP 118 An Integrated LC/MS Platform for Microscale
Applications; Angela Doneanu; Jim Murphy; Jay Johnson;
Steve Cohen; Giusseppe Astarita; Waters Corp., Milford,
MA
ThP 119 Maximizing Triple Quadrupole Mass Spectrometry
Productivity Through the Automated Use of an
Expanded Dual-Channel HPLC System with Online
Sample Cleanup; Kevin McCann; Sameer Nene; Doug
McIntyre; Edmond Neo; Dennis Nagtalon; Dorothy Yang;
Agilent Technologies, Santa Clara, CA
ThP 120 Extension of RExIC Ion Preselection to Low-Resolution
Ion Trap MudPIT Chromatography; Peter Leopold1;
Samantha Peacock2; Tahmid Hassan2; Keith Rivera2; Darryl
Pappin2; Cristian I. Ruse2; 1BioAnalyte Inc., Portland, ME;
2
Cold Spring Harbor Laboratory, Cold Spring Harbor, NY
LC-MS Sample Preparation (Proteins & Peptides), 121 – 139
ThP 121 The Effect of Protein Extraction Bias on the Biological
Interpretation of Biofilm Metaproteomes; Dagmar
Hajkova Leary2; William Judson Hervey IV. 1; Gary Vora1;
1
Naval Research Laboratory, Washington, DC; 2National
Research Council, Washington, DC
ThP 122 Specific and Efficient N-propionylation of histones with
Propionic acid N-hydroxysuccinimide Ester for Histone
Marks Characterization by LC-MS; Rijing Liao1; Yanyan
Yu1; shaolian zhou1; wei yi1; huili zhai2; 1China Novartis
Institutes for Biomedical Research, Shanghai, China;
2
Novartis Institutes for BioMedical Research, Inc., Boston,
MA
ThP 123 A New Sample Preparation Method for Tissue
Proteomics; Ying-Hua Chang1; Albert Chen1; Wei Guo1;
Qiang Xiong2; Jianyi Zhang2; Ying Ge1; 1University of
Wisconsin, Madison, WI; 2University of Minnesota Medical
School, Minneapolis, MN
ThP 124 An Optimized Method for Preparing Yeast and Human
Protein Extracts for Mass Spectrometry Method
Development and Instrument Validation; Sergei Saveliev;
Ethan Strauss; Mike Rosenblatt; Marjeta Urh; Promega
Corporation, Madison, WI
ThP 125 The Use of An Acid and Heat-Labile Surfactant for
Several Mass Spectrometry Sample Preparation
Methods; Michael Rosenblatt; Sergei Saveliev; Marjeta
Urh; Promega Corp, Madison, WI
ThP 126 Enhanced Protein Mass Spectrometry Analysis with
Trypsin/Lys-C Mix; Marjeta Urh1; Sergei Saveliev1; Ethan
Strauss1; Mike Rosenblatt1; Richard Jones2; Michael Ford
2
; Dave Allen2; 1Promega, Madison, WI; 2MSBioworks LLC,
Ann Arbor, MI

ThP 127 Recovery and Identification of High pI-High Charge
Peptides Separated from Proteins on Spin Filters Using
Elevated Organic Elution; Tatiana N. Boronina 1; AeRyon
Kim2; Yuri Poluektov2; Nelson Song2; Robert N. Cole1;
1
MSF, Johns Hopkins School of Medicine, Baltimore, MD;
2
Pathology, Johns Hopkins School of Medicine, Baltimore,
MD
ThP 128 Electroelution for Sample Preparation Enabling Top
Down Proteomics of Native and Denatured Proteins;
Luis Henrique Ferreira Do Vale1; Adam Catherman1;
John Tran1; Philip Compton1; Paul Thomas1; Edivaldo
Ximenes Filho2; Marcelo Valle de Sousa2; Neil Kelleher1;
1
Northwestern University, Evanston, IL; 2Universidade de
Brasilia, Brasilia, Brazil
ThP 129 Proteomic Analysis of the Murine Presynaptic Active
Zone by Fractionation at High pH and nLC-ESI-MS/MS;
Benjamin F. Mueller1; Melanie Lassek2; Marion Rohmer1;
Dominic Baeumlisberger3; Jens Weingarten2; Walter
Volknandt2; Michael Karas1; 1Goethe-University, Institute of
Pharm. Chemistry, Frankfurt am Main, Germany; 2GoetheUniversity, Institute of Neuroscience, Frankfurt am Main,
Germany; 3SunChrom GmbH, Friedrichsdorf, Germany
ThP 130 Effects of Matrix Age on Protein Binding Results
Extracted with a Prototype Phospholipid Removal Plate
and Analyzed Using MFLC-MS/MS; Chad Christianson;
Casey Johnson; Sharon Cox; Shane Needham; Alturas
Analytics, Moscow, ID
ThP 131 Critical Evaluation of the Effects of Various Sample
Clean Up Approaches for Micro Fluidic LC/MS in
Bioanalysis; Paul Rainville; Jim Murphy; Catalin Doneanu;
Waters, Milford, MA
ThP 132 Fast “Load-Wash-Elute” SPE Method with No Dry Down
Steps for Peptide Extraction from Plasma and Serum
Prior to LC-MS/MS Analysis; Victor Vandell1; Frank Kero1;
Wendy Hartsock1; Lee Williams2; Adam Senior2; Rhys
Jones2; Geoff Davies2; Alan Edgington2; Steve Jordan2;
1
Biotage, Charlotte, NC; 2Biotage GB Limited, Cardiff, UK
ThP 133 Robust Targeted Protein Quantification by LC-MS
Enabled by a Versatile Sample Preparation Platform
for Automated Protein Digestion and Cleanup; Jason
Russell; Michael Bovee; Zachary Van Den Heuvel; Scott
Fulton; Steve Murphy; Agilent Technologies, Inc., Madison,
WI
ThP 134 A Robust Human Plasma IgG1 Assay Using a microLCMS/MS System with Online Digestion; Hao Yang1; Nicole
Hebert1; David Neyer1; Tina Settineri1; Remco van Soest1;
Christie Hunter2; 1Eksigent, part of AB SCIEX, Dublin, CA;
2
AB SCIEX, Foster City, CA
ThP 135 An Optimized Sample Preparation Procedure for
Shotgun Proteomic Analyses of Complex Samples by
Mass Spectrometry; Babu Antharavally1; Xiaoyue Jiang2;
Robert Cunningham1; Ryan Bomgarden1; Yi Zhang2; Rosa
Viner2; John C. Rogers1; 1ThermoFisher Scientific, Rockford,
IL; 2Thermo Fisher Scientific, San Jose, CA
ThP 136 Needle-and-Frit-Aided In-Gel Digestion: An Improved
and More Reliable Method for Protein Identification in
Gel Approaches; Keding Cheng; Angela Sloan; Robert
Vendramelli; Stuart McCorrister; Lisa Podhorodecki; Kristen
M Avery; Lise Lamoureux; Garrett Westmacott; Sharon
Simon; Debra Godal; David Knox; Public Health Agency of
Canada, Winnipeg, Canada
ThP 137 Integrated Bead Elution to FASP Digestion Protocol for
Increased Protein Identification and Time Savings in
Affinity Enrichment Experiments; Anna Okumu1; Yujie
Tang2; Toshie Saito2; Allis Chien1; Chris Adams 1; 1Stanford
University Mass Spectrometry, Stanford, CA; 2Stanford
University, Stanford, CA

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ThP 138 Appropiate Digestion Protocol Ensures High Accuracy
and Precision in Protein Quantitation; Cristina Chiva;
Mireia Ortega; Eduard Sabidó; Proteomics Unit CRG/UPF,
Barcelona, Spain
ThP 139 Comparison of Protein Extraction, Digestion, and
Fractionation Methods for Discovery-Based, BottomUp Proteomics; Kerry Bauer; Leigh Weston; Amanda
Hummon; University of Notre Dame, Notre Dame, IN
Advances in Sample Preparation Methods for Improved
Protein Identification and Quantification, 140 – 169
ThP 140 Surface-Modified Nanoparticles as a Proteomics-Based
Diagnostic Tool; Carly N. Ferguson; Rolando E. Yanes;
Angela A. Hwang; Courtney R. Thomas; Jeffrey I. Zink;
Fuyuhiko Tamanoi; Joseph A. Loo; University of California,
Los Angeles, CA
ThP 141 Development of an On-line SDS Removal Platform
Using Asymmetrical Field-Flow Fractionation for
GELFrEE and Direct Analysis with Mass Spectrometry;
Ki Hun Kim1; John C. Tran1; Ryan T. Fellers1; Philip D.
Compton1; Paul M. Thomas1; Myeong Hee Moon2; Neil L.
Kelleher1; 1Northwestern Univeristy, Evanston, IL; 2Yonsei
University, Seoul, South Korea
ThP 142 Proteomic Analysis of Redox-Sensitive Cysteine
Residues Using Novel Chemical Probes; Yeon-seung
Park; Seulki Ha; Heejung Kim; Kong-Joo Lee; College of
Pharmacy, Ewha Womans Univ., Seoul, South Korea
ThP 143 “Gel-Aided Sample Preparation” (GASP) and “Charge
State Separation” (CSS) Enable Robust Sample
Generation and Data Acquisition for Deep Proteome
Coverage in Proteomics; Roman Fischer; Benedikt
Kessler; University of Oxford, UK, Oxford, UK
ThP 144 Optimizing Experimental Parameters for de-novo
Target Identification of Bioactive Molecules by
Chemoproteomics; Jason Murphy; Jason Thomas; David
Schwalb; Jane Nagel; Scott Brittain; Markus Schirle; Novartis
Institutes for BioMedical Research, Inc., Cambridge, MA
ThP 145 New Proteomics Approaches by Direct MALDI-MS
Analysis from Dry Polyacrylamide Gels and PVDF
Membranes Using Stain-Free Protein Detection; Stefan
Slamnoiu1; Christopher Schneider1; Bogdan Bernevic1;
Bernd Müller- Zülow2; Heinrich Spiecker2; Michael
Przybylski1; 1University of Konstanz, Konstanz, Germany;
2
LaVision-Biotec GmbH, Bielefeld, Germany
ThP 146 Primary Amine Modification with Sulfophenyl
Isothiocyanate for Negative Mode Peptide
Charge Enhancement and Enhanced 193 nm UV
Photodissociation; Joe R. Cannon; Sylvester M. Greer;
Jennifer S. Brodbelt; Univ. of Texas at Austin, Austin, TX
ThP 147 An Integrated Microfluidic Device for On-Line Trypsin
Digestion and LC/MS Analysis of Proteins; Roger
Moore1; Denise Keen1; Gabriel Gugiu1; Terry Lee1; Gregory
Staples2; Hongfeng Yin2; Reid Brennen2; Kevin Killeen2;
1
City of Hope, Duarte, CA; 2Agilent Technologies, Santa
Clara, CA
ThP 148 Aminoethylation of Hair Protein Cysteines in Parallel
with Carbamidomethylation for Improved Proteomic
Coverage; Richard A. Eigenheer; Robert H. Rice; Brett S.
Phinney; UC Davis, Davis, CA
ThP 149 Orthogonal-Specificity Proteases Double Proteome
Coverage; Jesse Meyer; Nuno Bandeira; Elizabeth
Komives; University of California, San Diego, CA
ThP 150 Fast and Efficient Proteolysis of Proteins by Pepsinencapsulated Magnetic Sol-Gel for Mass Spectrometry
Based Proteomics Applications; H. Mehmet Kayılı;
Selim Gerişlioğlu; Ömür Çelikbıçak; Bekir Salih; Hacettepe
University, Department of Chemistry, Ankara, Turkey

PAGE 158					

ThP 151 Global Proteomic Screening of Photocleavable BeadArrays Using Synchronized MALDI-MS and Fluorescent
Imaging; Mark Lim; Ziying Liu; Karen Braunschweiger;
Amany Awad; Kenneth Rothschild; AmberGen, Watertown,
MA
ThP 152 Streamlining Bottom-up Protein Identification Based on
Selective UVPD of Chromophore Tagged Histidine and
Tyrosine Containing Peptides; Julia Aponte; Lisa Vasicek;
Jagannath Swaminathan; Jennifer Brodbelt; University of
Texas, Austin, TX
ThP 153 Development of an Optimized Metaproteomic
Approach for Unraveling Inter-Individual Variation in
the Premature Infant Gut Microbiome; Weili Xiong2;
Jacque Young2; Paul Abraham2; Richard Giannone1; Robert
Hettich1; 1Oak Ridge National Laboratory, Oak Ridge, TN;
2
Univ. of Tennessee, Knoxville, TN
ThP 154 Tissue Sample Preparation Procedures for Low Scale
Shotgun Proteomics and MALDI Profiling; Rémi
Longuespée; Gabriel Mazzucchelli; David Calligaris;
Nicolas Smargiasso; Marie Alice Meuwis; Edwin De Pauw;
Mass Spectrometry Laboratory, 4000 Liège (Sart Tilman),
Belgium
ThP 155 Novel Aqueous Two-Phase Systems for Extraction of
Membrane Proteins in Human Embryonic Stem Cells;
James Mccord; Emine Gokce; Shuang Liang; Shan Randall;
David C. Muddiman; Morteza Khaledi; NC State University,
Raleigh, NC
ThP 156 An Improved Stable-Isotope N-ter-labeling Approach
with Light/Heavy TMPP to Automate Proteogenomics
Data Validation; Diego Bertaccini; Sebastien Vaca;
Christine Carapito; Alain Van Dorsselaer; Christine
Schaeffer-Reiss; LSMBO, Strasbourg, France
ThP 157 Use of Iron Oxide Nanoparticle Pellicles for Enrichment
of Plasma Membrane Proteins from Suspended Cells;
Waeowalee Choksawangkarn1; Sung-Kyoung Kim1; Lauren
Graham1; Nathan Edwards2; Sang Bok Lee1, 3; Suzanne
Ostrand-Rosenberg4; Catherine Fenselau1; 1University
of Maryland, College Park, MD; 2Georgetown University
Medical Center, Washington, DC; 3Korea Advanced Institute
of Science and Technology, Daejeon, Korea; 4University of
Maryland, Baltimore County, Baltimore, MD
ThP 158 A Novel Enrichment Strategy for N-terminal-oriented
Proteogenomics Challenges Dogma Related to the
Conservation of Translation Initiation amongst Closely
Related Species; Celine Bland; Bernard Fernandez; JeanCharles Gaillard; Jean Armengaud; CEA, Bagnols Sur
Ceze, France
ThP 159 Development and Applications of In-Gel MicrowaveAssisted Acid Hydrolysis (MAAH) of Proteins for
Mapping Protein Sequences; Difei Sun; Nan Wang; Liang
Li; University of Alberta, Edmonton, Canada
ThP 160 A Novel Method of the Enzyme Immobilization for the
Biological Applications; He-Hsuan Hsiao1; Henning
Urlaub2; 1NCHU, Department of Chemistry, Taichung,
Taiwan; 2MPIbpc, Bioanalytical Mass Spectrometry Group,
Göttingen, Germany
ThP 161 iFASP: Combining Isobaric Mass Tagging with FilterAided Sample Preparation; Gary McDowell; Hanno Steen;
Boston Children’s Hospital, Boston, MA
ThP 162 Digestion and Depletion of Abundant Proteins Improves
Proteome Coverage and Quantitation; Bryan Fonslow;
Jeffrey Savas; Navin Rauniyar; John Yates III; The Scripps
Research Institute, La Jolla, CA
ThP 163 Genetic Modification of the Urease Activity Enables Full
Compatibility of Fission Yeast with SILAC Labeling;
Alejandro Carpy Gutierrez Cirlos1; Avinash Patel2; Tay
Ye Dee2; Iain Hagan2; Boris Macek1; 1Proteome Center

61ST ASMS CONFERENCE ON MASS SPECTROMETRY

THURSDAY POSTERS

ThP 164

ThP 165

ThP 166

ThP 167

ThP 168

ThP 169

Tuebingen, Tuebingen, Germany; 2Paterson Institute for
Cancer Research, Manchester, UK
Novel Approach for the Absolute Quantification and
Multiplexing of Histone Post-Translational Modifications
(PTM) by Mass Spectrometry (MS); Leila Afjehi-Sadat1,
2
; Benjamin A Garcia1, 2; 1University of Pennsylvania,
Philadelphia, PA; 2Department of Biochemistry and
Biophysics, Philadelphia, PA
Sequential Acetyl Lysine Immunoprecipitation
Platform to Quantitatively Assess the p300
Dependent Acetylome; Timothy Sikorski; Roland Annan;
GlaxoSmithKline, Collegeville, PA
A Mass Spectrometry-Based Approach for Mapping
and Quantitation of Both Nitrosation and Oxidation of
the Cysteome; Sujeewa C. Piyankarage; Yue-Ting Wang;
Shuai Wang; Gregory R. J. Thatcher; Dept. of Medicinal
Chemistry and Pharmacognosy, Chicago, IL
Comparative Metaproteomics for the Canine Gut
Microbiome; Seijin Park; Cadie Tillotsen; Ryan Elizabeth;
Kenneth Reardon; Colorado State University, Fort Collins, CO
Exploring Nucleotide-Binding Proteins in Human Cell
Proteome with an Affinity-Labeled Nucleotide Probe;
Yongsheng Xiao; Yinsheng Wang; University of California,
Riverside, CA
Comparison of Proteins Bound to the Yeast UASGAL
Region Under Different Growth Conditions Using
GENCAP Technology; Prahlad Rao1, 2; Avinash Jadhav1,
2
; Hector Ahlers1, 2; Amy Ludwig-Kubinsky1, 2; Regina Cole1,
2
; Yuan Yuan1, 3; Mark Levenstein1, 3; Michael Shortreed1,
3
; Lloyd Smith1, 3; Michael Olivier1, 2; 1Wisconsin Center of
Excellence in Genomics Science, Milwaukee, WI; 2Medical
College of Wisconsin, Milwaukee, WI; 3University of
Wisconsin, Madison, WI
High Throughput Analysis/Robotics, 170 – 185

ThP 170 High-Throughput Validated Method for the Quantation
of 10, 11-dihydro-10-hydroxycarbamazepine in Serum
Using Ultra Fast SPE-MS/MS; Matthew Bjergum;
Darlington Danso; Eric Korman; Robert Enger; Paul Jannetto
Ph.D; Loralie Langman Ph.D; Mayo Clinic, Rochester, MN
ThP 171 High- Throughput Validated Method for the Quantitation
of Voriconazole in Serum Using Ultra-fast SPE-MS/MS;
Darlington Danso; Matthew Bjergum; Eric Korman; Robert
Enger; Paul Jannetto Ph.D; Loralie Langman Ph.D; Mayo
Clinic, Rochester, MN
ThP 172 Reducing Matrix Effect in Double-Sink PAMPA Analysis
by LC-MS/MS; Xianmei Cai; Chris Mayer; Anthony Paiva;
Ying.W. Li; John Herbst; Harold Weller; Wilson Shou;
Bristol-Myers Squibb.Co, Wallingford, CT
ThP 173 High-Throughput Validated Method for the
Quantification of Lamotrigine in Serum Using Ultra
Fast SPE-MS/MS; Matthew Bjergum; Darlington Danso;
Eric Korman; Robert Enger; Loralie Langman Ph.D; Paul
Jannetto Ph.D; Mayo Clinic, Rochester, MN
ThP 174 High-Throughput Validated Method for the
Quantification of Felbamate in Serum Using Ultra
Fast SPE-MS/MS; Matthew Bjergum; Darlington Danso;
Eric Korman; Robert Enger; Loralie Langman Ph.D; Paul
Jannetto; Mayo Clinic, Rochester, U.S
ThP 175 Laser Ablation Transfer with a Remote Sampling Arm;
Chinthaka A. Seneviratne; Kermit K. Murray; Louisiana
State University, Baton Rouge, LA
ThP 176 Fast Separation Method Development for ScaleUp Preparative Two-Dimensional (2D) SFC/SFC/MS
Separations; Yinong Zhang; Catherine Pham; Lu Zeng;
Takeda California, Inc., San Diego, CA

ThP 177 New Extraction Tips Technique for Direct Elution on
Plate used in LDTD-MS/MS Analysis; David Dube1; Serge
Auger2; Veronique Marceau1; Alex Birsan2; Annick Dion2;
Pierre Picard2; 1Silicycle, Quebec, Canada; 2Phytronix
Technologies, Quebec, Canada
ThP 178 Fast Compound Optimization and High-Throughput
Analysis Workflow by LDTD-MS/MS; Annick Dion; Serge
Auger; Pierre Picard; Phytronix Technologies, Quebec City,
Canada
ThP 179 A Fully Automated Method for High Throughput Draft
Level Protein Interactomics; Lola Fagbami1; Jinal Patel1;
Yashaswi Shrestha1; Jesse S. Boehm1; Zachary Van Den
Heuvel2; Steve Murphy2; Steven A. Carr1; Jacob D. Jaffe1;
1
Broad Institute of MIT and Harvard, Cambridge, MA;
2
Agilent Technologies, Inc., Santa Clara, CA
ThP 180 Rapid detection and Quantitation of Perchlorate in
Human Urine by Nanoelectrospray-Tandem Mass
Spectrometry; Amanda Woods; Chris Nixon; Shane
Wyatt; Commonwealth of Virginia Division of Consolidated,
Richmond, VA
ThP 181 Continuously Stirred Tank Reactor as a Flow
Injection Analysis Device for Non-covalent Binding
Determinations with ESI-MS; Kevin Schug1; Hui Fan1; Petr
Fryčák2; Sabra Ramirez1; 1University of Texas Arlington,
Arlington, TX; 2Palacký University, Olomouc, Czech
Republic
ThP 182 Mass Spectrometry Based Hit Triage: A Case Study on
a Protease Using RapidFire Mass Spectrometry; Juncai
Meng1; Gregory Adam1; Keith Rickert1; Anthony Kreamer1;
Daniel Stugan1; Justin Murray1; Edward Hudak1; Robert
Liehr1; Alex Wolicki1; Ming-Tain Lai3; Jay Grobler3; Paul
Zuck1; Eric Johnson2; Victor Uebele1; Jeffrey Hermes1;
1
Screening and Protein Sciences, Merck, North Wales, PA;
2
In Vitro Pharmacology, Merck, West Point, PA; 3Infectious
Disease, Merck, West Point, PA
ThP 183 High Through-put HPLC-MS Using Active Flow
Technology Chromatography Columns; Ross Shalliker;
Danijela Kocic; Arianne Soliven; University of Western
Sydney, North Paramatta, Australia
ThP 184 Facile Modifications to Commercially Available
HPLC System Enabling Medium Throughput Mass
Spectrometry Based Screening; Stefan Thibodeaux;
David Yurek; Rebecca Butler; Ming-Shang Kuo; Eli Lilly,
Indianapolis, IN
ThP 185 Chromatographic Optimization, Storage, and re-Use in
a combined High-Throughput Compound Optimization
Workflow Using a Dual Arm Autosampler; Wayne
Lootsma1; Nick Levitt2; Brendon Kapinos3; Veronica
Zelesky3; 1Sound Analytics, LLC, Niantic, CT; 2TwoCenter
Technologies LLC, Cambridge, MA; 3Pfizer Inc., Groton, CT
GCMS: Instrumentation & Applications, 186 – 214
ThP 186 Classification of Conventional and Organic Basils
Using Gas Chromatography/Mass Spectrometry and
Chemometric Analysis; Zhengfang Wang1; Pei Chen2;
Liangli Yu3; Peter Harrington1; 1Ohio University, Athens, OH;
2
United States Department of Agriculture, Beltsville, MD;
3
University of Maryland, College Park, MD
ThP 187 Development of an Expedited Field Study Method
for PCBs in Sediments and Soils Using Portable GC/
MS; Mengliang Zhang1; Peter Harrington1; Natalie Kruse1;
Jennifer Bowman1; Stephen Lammert2; Edgar Lee2;
Glen Jackson1, 3; 1Ohio University, Athens, OH; 2Torion
Technologies Inc, American Fork, UT; 3West Virginia
University, Morgantown, WV

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ThP 188 Sample Identification by GC-MS and How to Improve
it; Aviv Amirav1, 2; Alexander Fialkov1; Tal Alon1, 2; 1Tel-Aviv
University, Tel-Aviv, Israel; 2Aviv Analytical LTD, Tel Aviv,
Israel
ThP 189 Determination of 55 Residual Pesticides in Onion and
Leek Samples Using GC-MS/MS; Feifei Tian; Peng Gao;
Furong Wang; Jun Fan; Shimadzu Global COE, Shimadzu
(China) Co., Ltd, Beijing, China
ThP 190
ThP 191 Applications of Accurate Mass Gas Chromatography/
APCI/Mass Spectrometry on a Quadrupole Timeof-Flight Instrument; Jeffrie Godbey; Jeffrey Gilbert;
Brita McNew; Mary Evenson; Ayanna Jackson; Dow
AgroSciences, Indianapolis, IN
ThP 192 Flavor Profiles of Imported and Domestic Beers over
Time by Purge and Trap Thermal Desorption GC/MS;
Ronald Shomo; Robert Frey; Christopher Baker; John
Manura; Scientific Instrument Services, Ringoes, NJ
ThP 193 Determination of Aromatic Amines in Mainstream
Smoke from Major US Brand Cigarettes Using SPE-GCMS/MS; Bryan Hearn1; Yanfeng Chen1, 2; Jennye Ward1;
Jacki Janecek1; Yan Ding1; Clifford Watson1; 1Centers for
Disease Control and Prevention, Atlanta, GA; 2Battelle,
Atlanta, GA
ThP 194 Enhanced Method Development Capability with
Automated SPME Extraction Optimization; Roger
Pearson1; Douglas Doster1; Tom Flug2; Guenter Boehm2;
1
Aspen Research Corporation, Maple Grove, MN; 2CTC
Analytics, Geneva, Switzerland
ThP 195 Coupling Post-Column Cryogenic Trapping with
Conventional GC/MS for the Analysis of Volatile Organic
Compounds; Abayomi Olaitan1; Behrooz Zekavat1; David
LaBrecque2; Touradj Solouki1; 1Baylor University, Waco, TX;
2
University of Maine, Orono, ME
ThP 196 Gas Chromatography Tandem Mass Spectrometry of
Odor-Active Pyrazines in Wine; Anna K. Hjelmeland1,
3
; Phillip L. Wylie2; Susan E. Ebeler1, 3; 1Department of
Viticulture and Enology, UC Davis, Davis, CA; 2Agilent
Technologies, Wilmington, DE; 3Food Safety and
Measurement Facility, UC Davis, Davis, CA
ThP 197 Spectral Accuracy Approach to Counting Sulfurs in
Unknown Compounds by Unit Mass Resolution Single
Quadrupole Systems; Hongliang (Leo) Xu; Yongdong
Wang; Ming Gu; Cerno Bioscience, Norwalk, CT
ThP 198 Nitrogen as an Alternative GC/MS Carrier Gas; Adam
J. Patkin; Andrew Tipler; Ruben Garnica; PerkinElmer,
Shelton, CT
ThP 199 Method Development for Fast, Automated Home-Made
Explosives Identification following Sample Introduction
on a Man Portable GC/MS; Gareth Dobson; Edward
Kissel; Michael Mark; Nickesha Chung; Eric Diken; Smiths
Detection, Danbury, CT
ThP 200 Analysis of Residual Ethylene Oxide in Intraocular
Lenses Using HS-GCMS; Dheeraj Handique; Durvesh
Sawant; Ankush Bhone; Prashant Hase; Sanket
Chiplunkar; Jitendra Kelkar; Ajit Datar; Pratap Rasam;
Shimadzu Analytical (India) Pvt. Ltd., Andheri (E), Mumbai,
Maharashtra, India
ThP 201 Determination of Fatty Acids in Foods Using Gas
Chromatography with Positive-ion Chemical Ionization
Tandem Mass Spectrometry; Shuichi Kawana1; Yukihiko
Kudo1; Yuki Sakamoto1; Katsuhiro Nakagawa1; Laura
Chambers2; Richard Whitney2; Haruhiko Miyagawa1;
1
Shimadzu, Kyoto, Japan; 2Shimadzu Scientific Instruments,
Columbia, MD

PAGE 160					

ThP 202 Comparison of Performance between Photoionization
and Field Ionization by Using GC-HRTOFMS; Koji
Okuda1; Kiyotaka Konuma1; Jun Onodera1; Tetsuo Higuchi1;
Yukinori Yahata1; Jonathon Bunn2; Akihiko Kusai1; 1JEOL
Ltd., 1-2 Musashino 3-Chome Akishima, Japan; 2JEOL
USA, Inc., Peabody, MA
ThP 203 Automated Sample Preparation for the Analysis of
Estrone by GC Triple Quadrupole Mass Spectrometry;
Peter Mrozinski1; Selene Hernandez-Ruiz2; Anthony
Macherone1; 1Agilent Technologies, Wilmington, DE;
2
University of Arizona, Tuscon, AZ
ThP 204 Microfabricated Multi-layered Columns for 2D Gas
Chromatography Mass Spectrometry; Sanggoo Kim;
Sung Min Lim; Korea Basic Sci. Institute, Seoul, South
Korea
ThP 205 Quantitation of Pyrethroids in Rat Plasma and Tissues
Using Gas Chromatography Negative Chemical
Ionization Mass Spectrometry; Darren Gullick; University
of Georgia, Athens, GA
ThP 206 Identification of Errors in EI Mass Spectral Databases
and Their Potential Impact on the Identification
of Unknowns Using Mass Spectrometry; O. David
Sparkman; Ryan Moffett; Mathew Curtis; Patrick Batoon;
University of the Pacific, Stockton, CA
ThP 207 Characteristics of Charge Exchange Chemical
Ionization (CI) in an Atmospheric Pressure Gas
Chromatography (APGC) Source and Applied Uses;
Steven Lai1; Rhys Jones2; David Douce2; Jody Dunstan
2
; Douglas Stevens3; 1Waters Corporation 1, Beverly,
MA; 2Waters Corporation 2, Manchester, UK; 3Waters
Corporation 3, Milford, MA
ThP 208 Development of a High-Sensitivity GC-MS/MS Method
for the Absolute Quantitation of TMS-Derivatized
Steroids; Matt Sweeney; Karolina M. Krasinska; Allis
S. Chien; SU Mass Spectrometry, Stanford University,
Stanford, CA
ThP 209 Optimizing GCMS Performance for Lowest Detection
Limits and Highest Dynamic Range; Barbara Bolton;
Brian Hom; Jim Oppenheimer; Agilent Technologies, Santa
Clara, CA
ThP 210 Testing the Limits of a New, Extremely Accurate
Retention Prediction Methodology for GC (www.
retentionprediction.org); Michael Wilson; Brian Barnes;
Paul Boswell; University of Minnesota, Saint Paul, MN
ThP 211 A Fast, Easy Way to Measure Your GC Instrument and
Column Suitability with a Mass Spectrometer (www.
checkyourgc.org); Joe Kell; Mike Wilson; Paul Boswell;
University of Minnesota, St. Paul, MN
ThP 212 Isotope Analysis in Reforming Reaction to Verify
the Carbon Source; Hyokeun Park; WooSung Jeon;
SeungJae Lee; InHyuk Son; Samsung Advanced Institute of
Technology, Yongin, South Korea
ThP 213 An Unusual Fragmentation Mechanism Deduced in the
Process of Identifying an Unknown from Its EI Mass
Spectrum; Dazhou Xang; Patrick Batoon; Liang Xue; O.
David Sparkman; Mathew Curtis; University of the Pacific,
Stockton, CA
ThP 214 On-line Micro-Reactors for Gas Chromatography
Isotope Ratio Mass Spectrometry; Herbert Tobias; Calvin
Patten; J. Thomas Brenna; Cornell University, Ithaca, NY

61ST ASMS CONFERENCE ON MASS SPECTROMETRY

THURSDAY POSTERS

High Mass Accuracy / High Performance
MS: Instrumentation, 215 – 229
ThP 215 In-Cell Accumulation of Ions for Control of TOF
Mass Discrimination in External Source FT-ICR
Mass Spectrometry; Steve Beu1; Nathan Kaiser2; Chris
Hendrickson2, 3; Alan Marshall2, 3; 1S C Beu Consulting,
Austin, TX; 2National High Magnetic Field Laboratory,
Tallahassee, FL; 3Florida State University, Tallahassee, FL
ThP 216 Experimental Evaluation of Current State of the Art
FT-ICR Cell Technology; Nathan Kaiser 1; Tong Chen1;
John Quinn1; Steve Beu2; Christopher Hendrickson1; Alan
Marshall1, 3; 1National High Magnetic Field Laboratory,
Tallahassee, FL; 2S C Beu Consulting, Austin, TX; 3Florida
State University, Tallahassee, FL
ThP 217 Advanced Experimental Event Sequences and Hardware
for Highest Mass Accuracy of Complex Mixtures by FTICR MS; Greg T. Blakney1; Nathan Kaiser1; Brian Ruddy2;
Ryan P. Rodgers1, 2; Alan G. Marshall1, 2; 1National High
Magnetic Field Laboratory, Tallahassee, FL; 2Florida State
University, Tallahassee, FL
ThP 218 A Simplifying Strategy for Tuning High-Order
Compensation Traps in FTMS; Don L. Rempel; Sergio
Castro; Michael L. Gross; Washington University, St Louis,
MO
ThP 219 Advanced Signal Processing Methods for FTMS:
Implementation and Characterization; Anton N.
Kozhinov1; Tagir Aushev2; Yury O. Tsybin1; 1Ecole
Polytechnique Fédérale, Lausanne, Switzerland; 2Institute
for Theoretical and Experimental Physics, Moscow, Russia
ThP 220 Improved Sensitivity and Resolution for Twodimensional FT-ICR MS; Maria van Agthoven1; David
Kilgour1; Lionel Chiron2; Marie-Aude Coutouly3; Marc-André
Delsuc2, 3; Mark Barrow1; Peter O’Connor1; 1Department
of Chemistry, University of Warwick, Coventry, UK;
2
IGBMC, Illkirch-Graffenstaden, France; 3NMRTEC, IllkirchGraffenstaden, France
ThP 221 Enabling Accurate Mass Elemental Composition
Determination on a New Compact Mass Spectrometer
– Application to Detection and Identification of
Radiopharmaceuticals; Simon J. Prosser1; Daniel Eikel1;
Thien Dinh1; Frederick Chin2; Ming Gu3; YongDong Wang3;
1
Advion, Inc., Ithaca, NY; 2Stanford University Medical
Center, Stanford, CA; 3Cerno Biosciences, Norwalk, CT
ThP 222 An Induced Dual-Nanospray Internal Calibration Ion
Source for Mass Calibration with Simultaneously
Detected Reference Ions and Analyte Ions; Yafeng Li1,
3
; Yiming Zhang2; Ning Zhang1, 3; Jianing Wang1, 3; Yueming
Zhou1, 3; Caiqiao Xiong1, 3; Suming Chen1, 3; Zongxiu Nie1, 4;
Li Zhou2; Xiang Pan2; Zhaogui Liu2; 1Institute of Chemistry
Chinese Academy of Sciences, Beijing, China; 2Jiangsu
Skyray Instrument Co., Ltd, Kunshan, Suzhou, China;
3
Beijing National Laboratory for Molecular Sciences, Beijing,
China; 4Beijing Center for Mass Spectrometry, Beijing, China
ThP 223 Radical Directed Dissociation of Peptides and
Proteins by UV Photodissociation and High Resolution
FT-ICR MS; Xing Zhang1; Benjamin Moore1; Piriya
Wongkongkathep2; Jiang Zhang2; Shijun Cheng1; Zhong
Chen1; Rachel Loo2; Joseph Loo2; Daniel Gallie1; Ryan
Julian1; 1University of California, Riverside, CA; 2University
of California, Los Angeles, CA
ThP 224 Taking High Resolution Data LC/MS Reduction to the
Next Level for Reduced False Positive Detection and
Increased Mass Accuracy; Mark A. Bayliss1; Stephane
Murphy1; Joseph Simpkins1; Ann Knolhoff2; Timothy Croley2;
John Callahan2; 1Virscidian Inc, Cary, NC; 2FDA, Center for
Food Safety & Applied Nutrition, College Park, MD

ThP 225 Compound ID and Structure Elucidation in Drug
Discovery - Medicinal Chemistry by Automated FTICR,
Accurate Mass Measurement, and MSn Methodologies;
Charles W. Ross III; Vincent Van Nostrand; Merck & Co.
Inc., West Point, PA
ThP 226 Evaluation of a Hybrid Quadrupole-Orbitrap Mass
Spectrometer (Q Exactive) for Quantitative Bioanalytical
Support of in vitro Screening Assays; Jennifer Maloney1;
Keeley Murphy2; Jeremy Stewart1; John Herbst1; Dieter
Drexler1; Harold Weller1; Wilson Shou1; Jun Zhang1; 1BristolMyers Squibb, Wallingford, CT; 2ThermoFisher Scientific,
San Jose, CA
ThP 227 Maximizing Spectrum Identification Rate in Shotgun
Proteomics on the Q Exactive Mass Spectrometer; Yue
Xuan; Eugen Damoc; Andreas Kuehn; Catharina Crone;
Markus Kellmann; ThermoFisherScientific, Bremen, Germany
ThP 228 A High Resolution Accurate Mass Approach for Ultra
High Throughput Screening Plasma Protein Binding;
Keeley Murphy 1, 2, 3; Patrick Bennett1, 2, 3; Maciej Bromirski1,
2, 3
; Francois Espourteille1, 2, 3; 1Thermo Fisher Scientific,
Bremen, Germany; 2Thermo Fisher Scientific, San Jose,
CA; 3Thermo Fisher Scientific, Franklin, MA
ThP 229 Data Independent Acquisition (DIA) Analysis
on the Q Exactive Mass Spectrometer; Yue
Xuan1; Reiko Kiyonami3; Jarrett Egertson2; Michael
MacCoss2; Andreas Kühn1; Andreas Hühmer3; Markus
Kellmann1; 1ThermoFisherScientific Bremen, Bremen,
Germany; 2University of Washington, Seattle, CA;
3
ThermoFisherScientific San Jose, San Jose, CA
High Mass Accuracy / High
Performance Applications, 230 – 249
ThP 230 Mass Spec Quantification of a Steroid Hormone that
Regulates Development and Aging in C. elegans; TieMei Li1, 3; Jie Chen2; Xiangke Li1; Xiao-Jun Ding1; She Chen1;
Xiaoguang Lei1, 2; Meng-Qiu Dong1; 1National Institute of
Biological Sciences, Beijing, China; 2Tianjin University,
Tianjin, China; 3Beijing Normal University, Beijing, China
ThP 231 Neutron-Encoded Signatures to Distinguish N and
C-terminal Product Ions; Alicia Richards; Catherine E.
Vincent; Christopher M. Rose; Michael S. Westphall; Joshua
J. Coon; University of Wisconsin, Madison, WI
ThP 232 Increased SILAC Multiplexing via Neutron Encoding
(NeuCode) Tracks Proteome Remodeling during Murine
Myogenic Differentiation; Timothy W. Rhoads; Alexander
S. Hebert; Anna E. Merrill; Amelia J. Still; David J. Pagliarini;
Michael S. Westphall; Joshua J. Coon; University of
Wisconsin, Madison, WI
ThP 233 Comparison of HRMS to Triple Quadrupole Mass
Spectrometer: Quantitation of Monatin and Its
Metabolite Using Q Exactive and API 4000; Hui Tao;
Changyu Quang; Brett Dunbar; Spencer Carter; WIL
Research, Ashland, OH
ThP 234 HPLC-Q/TOF Screening for Substituted Cathinones
in Legal Highs - The Case of 3,4-methylenodioxy
Derivatives; Emilia Fornal; The John Paul II Catholic
University of Lublin, Lublin, Poland
ThP 235 Enhanced Occupational Drug Screening Using High
Resolution Accurate Mass LCMS; Jeremy Cook2; Bob
Gray1; Simon Hudson1; 1HFL Sport Science, Fordham, UK;
2
LGC, Teddington, UK
ThP 236 Identification of Shikimate Kinase (MtSK) Inhibitors
among anti-Mycobacterium tuberculosis Compounds
by LC-MS; Johayra Simithy1; Nathaniel Reeve1; Judith
Hobrath2; Robert Reynolds2; Angela Calderon1; 1Auburn
University, Auburn, AL; 2Southern Research Institute,
Birmingham, AL

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ThP 237 Identification, Quantification and Confirmation of Nontargeted Potato Glycoalkaloid Contaminants in Dog
Food Using a High Resolution/Accurate Mass LC/MS;
Jack J. Lohne; Sherri B. Turnipseed; Wendy C. Andersen;
Mark Madson; US Food and Drug Administration, Denver, CO
ThP 238 Elucidation of MS/MS Ion Fragments of Veterinary
Drugs for Qualitative Regulatory Purposes Using ESIQ-TOF; Alberto Nuñez 1; Lucía Geis-Asteggiante2; Steven
Lehotay1; 1USDA-ARS-ERRC, Wyndmoor, PA; 2University
of Maryland, College Park, MD
ThP 239 Examination of Urinary Biochemical Complexation with
Hg(II) by Electrospray Ionization FT-ICR and Tandem
Mass Spectrometry; Troy Wood; Zachary Fine; University
at Buffalo, Buffalo, NY
ThP 240 Chelomics: Discovery and Identification of Organic
Metal Chelating Compounds in Natural Samples and
Biological Media by High Resolution LC-MS; Oliver
Baars; David H. Perlman; Francois M. M. Morel; Princeton
University, Princeton, NJ
ThP 241 Identification of the Interaction of Trivalent Arsenicals
with Metallothionein by Use of Ultrahigh Resolution
Mass Spectrometry; Shanshan Feng1; Shi-Jian Ding1;
Puttappa R Dodmane1; Jenna Scotcher2; Lora L Arnold1;
Nicolas L. Young2; Alan G. Marshall2; Samuel M Cohen1;
1
Univ of Nebraska Med Center, Omaha, NE; 2Florida State
University, Tallahassee, FL
ThP 242 Middle-down Proteomics Workflow Targeting 3-7 kDa
peptides for Clinical Applications; Ünige A. Laskay1;
Kristina Srzentić1; Anna A. Lobas2; Tanja Panić-Janković3;
Michel Monod4; Mikhail V. Gorshkov2; Goran Mitulović3; Yury
O. Tsybin1; 1Ecole Polytechnique Fédérale de Lausanne,
Lausanne, Switzerland; 2Institute for Energy Problems of
Chemical Physics, Moscow, Russia; 3Medical University of
Vienna, Vienna, Austria; 4Centre Hospitalier Universitaire
Vaudois, Lausanne, Switzerland
ThP 243 Screening and Characterization of Reactive
Compounds with in vitro Peptide-Trapping and Liquid
Chromatography-High Resolution Accurate Mass
Spectrometry (LC-HRMS); Cong Wei; Louis S. Chupak;
Thomas Philip; Benjamin M. Johnson; Robert Gentles;
Dieter M. Drexler; Research&Development, Bristol-Myers
Squibb Company, Wallingford, CT
ThP 244 Application of Differential Mobility Spectrometry
Technology and HR/AM Quadrupole-Orbitrap and
Quadrupole-TOF Mass Spectrometry in High-throughput
Quantitative Bioanalysis; Yao Shi1; Keeley Murphy2;
Patrick Bennett2; Xiangyu Jiang1; Douglas Fast1; 1Covance
Inc., Madison, WI; 2Thermo Fisher Scientific, San Jose, CA
ThP 245 High Throughput Quantitative Analysis for LogD
Determination: Comparison of High Resolution LCMS
to LCMSMS; Joseph Pease1; Baiwei Lin1; Kate Comstock2;
1
Genentech, Inc., South San Francisco, CA; 2Thermo Fisher
Scientific, San Jose, CA
ThP 246 A Benchtop High Resolution Mass Spectrometry
System for Rapid Identification of Pharmaceutical
Impurities; Baiwei Lin1; Kate Comstock2; Joseph Pease1;
1
Genentech, South San Francisco, CA; 2Thermo Fisher
Scientific, San Jose, CA
ThP 247 Sensitive Quantification of Key Oxysterols in Biological
Matrix Using Liquid Chromatography with High
Resolution Accurate Mass Spectrometry; Daniel Arndt;
Philip Morris International R&D, Neuchatel, Switzerland
ThP 248 Employing Advanced High Resolution Mass
Spectrometry Techniques to Study Metabolism of Crop
Protection Products, Actives, and Leads without RadioLabels ; Yelena A. Adelfinskaya; Jesse L. Balcer; Jeffrey R
Gilbert; Gerrit DeBoer; Olena Castello; Dow AgroSciences,
Indianapolis, IN

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ThP 249 Ultrahigh Mass Accuracy and Mass Resolution FT-ICR
MS: Identification of All Possible CcHhNnOoSs13Ccc34Sss
Compositions in Complex Mixtures; Yuan Mao1; Nicolas
L. Young2; Christopher L. Hendrickson2; Alan G. Marshall1,
2 1
; Florida State University, Tallahassee, FL; 2National High
Magnetic Field Laboratory, Tallahassee, FL
Peptides: General, 250 – 262
ThP 250 Enhancement of Protonation for ESI on Non-Basic
Peptides; Changgeng Feng; Carolyn Cassady; The
University of Alabama, Tuscaloosa, AL
ThP 251 MALDI-MS Based Identification of Proteins
and Peptides in Fingermarks; Ekta Patel1; Peter
Marshall2; Andy West2; Malcolm Clench1; Simona
Francese1; 1Biomedical Research Centre, Sheffield, UK;
2
GlaxoSmithKline, Stevenage, UK
ThP 252 In-a-tip Omics Using Mass Spectrometer with a NanoElectrospray Ionization; Ai Fujita1; Iwao Sakane2; Tsutomu
Masujima1; 1Riken, Suita, Japan; 2Itoen, Makinohara, Japan
ThP 253 A Post-Column Solvent Make-Up Device in LC-ESI-MS
for Increasing the Detection Number of Proteotypic
Peptides; Hao-Lun Huang; Shin-Ying Dai; Sheng-Huang
Wu; Kuo-Lung Ku; National Chiayi University, Chiayi City,
Taiwan
ThP 254 Translating Retention Times of Target Peptides Across
LC-MS Proteomic Platforms; James J Walters; Kevin Ray;
Sigma-Aldrich, St. Louis, MO
ThP 255 Identification and Quantification of Carbohydrate
Binding Epitope Structures in Galectins by CREDEX-MS
and HDX-MS; Frederike Eggers1; Adrian Moise1; Claudia
S. Maier2; Michael Przybylski1; 1University of Konstanz,
Konstanz, Germany; 2Oregon State University, Corvallis, OR
ThP 256 Collision Induced Dissociation of Protonated and
Metalated Beta-Peptides; Nicole Burke1; Samuel Gellman2;
Timothy Zwier1; Scott McLuckey1; 1Purdue University,
Lafayette, IN; 2University of Wisconsin, Madison, WI
ThP 257 Proton Affinity of Short Oligopeptides Containing
Lysine and Lysine Homologs; Patrickhenry Batoon;
Robert Harper; Jianhua Ren; University of the Pacific,
Stockton, CA
ThP 258 MSn Characterization of Peptide Prodrugs Containing
Fully Protected, Esterase-labile Phosphothreonine;
Christopher Lai; Wen-Jian Qian; Terrence Burke, Jr; James
Kelley; National Cancer Institute, NIH, FNLCR, Frederick, MD
ThP 259 Sequence Tag and de novo Approaches for Peptide
Matching and Protein Identification for the Burmese
Python; LeeAnn Higgins 1; Charles Determan2; Todd
Markowski1; Gregory Beilman3; 1University of Minnesota
TC-StP, St. Paul, MN; 2University of Minnesota D, Duluth,
MN; 3University of Minnesota TC-MPLS, Minneapolis, MN
ThP 260 Improving Peptide Detection with Precise Nanofluidic
Control and Mixing of Solution Additive Post-Column;
Nicole Hebert2; J.C. Yves Leblanc1; Stephen Tate1; Thomas
Covey1; 1AB SCIEX, Concord, On, Canada; 2Eksigent, a
part of AB Sciex, Dublin, CA
ThP 261 Characterizing D-Amino Acid-Containing Peptides in
Aplysia californica; Itamar Livnat; Stanislav S. Rubakhin;
Elena V. Romanova; Jonathan V. Sweedler; University of
Illinois at Urbana-Champaign, Urbana, IL
ThP 262 Automation of Metal-Ion Binding Site Localization
Procedure in Peptides; Maria Indeykina1, 2; Dmitry
Podgrudkov4; Igor Popov1, 3; Alexey Kononikhin1, 2; Eugene
Nikolaev1, 2; 1Emanuel Institute of Biochemical Physics,
Moscow, Russia; 2Institute for Energy Problems of Chemical
Physics, Moscow, Russia; 3Moscow Institute of Physics and
Technology, Moscow, Russia; 4Lomonosov Moscow State
University, Moscow, Russia

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Peptidomics, 263 – 271
ThP 263 Modern-day MS Based Unlabeled Secretome Analysis
of conditioned Culture Media Reveals Novel Aspects of
Cell Biology, from Microorganisms to Human; Martijn W.
Pinkse; Peter D. Verhaert; Delft University of Technology,
Delft, Netherlands
ThP 264 Analysis of the Plasma Peptidome-Degradome Using
Phospholipid Extraction Plates and Mass Spectrometry;
Tony Tegeler; Michael Syring; Konstantinos Petritis;
Translational Genomics Research Institute, Phoenix, AZ
ThP 265 Extensive Identification and Quantitation of Milk
Endogenous Peptides by Mass Spectrometry; Andres
Guerrero1; Dave C. Dallas2; Nora Khaldi3; Daniela Barile2; J.
Bruce German2; Carlito B. Lebrilla1; 1UC Davis, Chemistry
Department, Davis, CA; 2UC Davis, Food Science
Department, Davis, CA; 3Food for Health Ireland, University
College Dublin, Belfield, Ireland
ThP 266 The Hunt for Novel Proteins Encoded by Small Open
Reading Frames; Amanda Nouwens; Nur Zainal; Wai Ning
Ng; Lexie Friend; Sumaya Al-Mansoori; Joe Rothnagel; The
University of Queensland, St Lucia, Australia
ThP 267 The Investigation of Neuropeptides in Crustacean to
Reveal the Neurotoxicity of Nanoparticles by MALDIMS; Chuanzi OuYang1; Hui Ye2; Grover Chang2; Lingjun Li1,
2 1
; Department of Chemistry, UW, Madison, WI; 2School of
Pharmacy, UW, Madison, WI
ThP 268 Data Independent Acquisition and Quantitation of
Isotopically Labeled Neuropeptides in Low Temperature
Stressed Cancer irroratus; Kevin Hayes; Claire
Schmerberg; Lingjun Li; University of Wisconsin, Madison, WI
ThP 269 Mass Spectral Characterization of the Neuropeptidome
of the Crayfish Orconectes rusticus; Zhidan Liang; Claire
Schmerberg; Lingjun Li; UW, Madison, WI
ThP 270 Mass Spectrometric Characterization of the Neuropeptidome
in the Dungeness Crab (Cancer magister); Qing Yu; Chenxi
Jia; Lingjun Li; University of Wisconsin, Madison, WI
ThP 271 A Multi-scale Strategy for Quantitative Neuropeptidomic
Analysis of Food Intake; Chenxi Jia; Qing Yu; Christopher
Lietz; Lingjun Li; UW, Madison, WI
Peptides: Sequence Analysis, 272 – 278
ThP 272 ISD High-Throughput Platform for the Sequencing of
Animal Toxins; Michel Degueldre1; Loïc Quinton1; Nicolas
Smargiasso1; Gabriel Mazzucchelli1; Pierre Escoubas2; Eric
Opsomer3; Nicolas Vandewalle3; Edwin De Pauw1; 1Laboratory
of Mass Spectrometry, ULg, Liège, Belgium; 2VenomeTech,
Valbonne, France; 3GRASP, ULg, Liège, Belgium
ThP 273 Rapid Protein Sequencing Using TripleTOF™ 5600
System with MRMPilot™ and ProteinPilot™ Software;
Yan Ke; Nicole Roenker; Elise Snider; Yong-Xi Li; Medpace,
Cincinnati, OH
ThP 274 Reversed-phase HPLC and Mass-Spectrometry Analysis
of Cyclolinopeptides; Ying W. Lao1; Kim MacKenzie2;
William Vincent2; Oleg V. Krokhin1; 1University of Manitoba,
Winnipeg, Canada; 2Shape Foods Inc., Brandon, Canada
ThP 275 Identification of Mutated Peptides/Proteins Driving
Cancer Phenotype Utilizing Improved Shotgun
Proteomics and Data Analysis Approaches; Gurkan
Bebek; Giridharan Gokulrangan; Hua Xu; Mark Chance; Case
Western Reserve University, Cleveland, OH
ThP 276 Mass Spectrometric Deconvolution of Nonribosomally
Synthesized Microbial Microheterogeneous Lipopeptide
Library; Khyati Pathak1; Hareshkumar Keharia2; Kallol
Gupta1; 1Molecular Biophysics Unit,IISC, Bangalore,
India; 2BRD School of Biosciences, S.P.University,
Vallabhvidyanagar, India

ThP 277 Utilization of a2b2 Ions as a Filter of Peptide Candidates
Prior to Database Searching; Fedor Kryuchkov; Thiago
Verano-Braga; Frank Kjeldsen; University of Southern
Denmark, Odense, Denmark
ThP 278 SS bonds Oxidation for the Efficient de novo ESI-MS/
MS Sequencing of Non-Tryptic Disulfide-Containing
Peptides; Tatiana Samgina1; Yegor Vorontsov1; Vladimir
Gorshkov1; Konstantin Artemenko2; Konstantin Karandashev1;
Albert T. Lebedev1; 1Moscow State University, Moscow,
Russian Federation; 2Uppsala University, Uppsala, Sweden
Phosphopeptides: Quantitative Analysis, 279 – 306
ThP 279 Electron Capture Dissociation Can Quantify the Relative
Concentration of Phosphopeptides in a Solution;
Soeren Bak1; Kim F. Haselmann2; 1Analytical Biosciences;
Department of Pharmacy; Fa, København Ø, Denmark;
2
Department of Chemistry, Univ of Southern Denmark,
Odense, Denmark
ThP 280 Quantitative Global Phosphoprotemics of a MAPK-AKT
Dual Pathway Inhibitor Anti-Cancer Drug; Daniela M
Schlatzer 1; Giridharan Gokulrangan1; Neil Dhawan2; Michael
Ohlmeyer2; Avi Ma’ayan2; Sahar Mazhar1; Mark R. Chance1;
Goutham Narla1; 1Case Western Reserve University,
Cleveland, OH; 2Mount Sinai School of Medicine, New York
City, New York
ThP 281 Identification of Downstream mTORC1/2 Activity
Markers in Breast Cancer by Means of Label-Free
Phosphoproteomics; Edmund Wilkes1, 2; Pedro Cutillas1, 2;
1
MRC Clinical Sciences Centre, London, UK; 2Barts Cancer
Institute, London, UK
ThP 282 Mass Spectrometry Reveals Alternative in vivo AutoActivation Mechanisms of the S Phase Checkpoint
Kinase Rad53; Eric Sheng-Wen Chen1; Nicolas Hoch2;
Shun-Chang Wang1; Achille Pellicioli3; Jörg Heierhorst2; MingDaw Tsai1; 1Academia Sinica, Taipei, Taiwan; 2St. Vincent’s
Institute, Melbourne, Australia; 3University of Milan, Milan, Italy
ThP 283 New Strategy for Selective 18O labeling of
Phosphopeptides; Waleed Alghamdi2; Simon Gaskell1;
Jill Barber3; 1Queen Mary University, London, UK; 2King
Abdulaziz City for Science and Technology, Riyadh, Sudi
Arabia; 3University of Manchester, Manchester, UK
ThP 284 Site-Specific Kinetic Analysis of Wildtype Sic1
Phosphorylation by Liquid Chromatography Fourier
Transform-Ion Cyclotron Resonance Mass Spectrometry;
Wendi A. Hale; Lian Zhu; Xiaoxia Nina Lin; Kristina
Hakansson; University of Michigan, Ann Arbor, MI
ThP 285 Sheathless Capillary Electrophoresis Electrospray Mass
Spectrometry (CESI-MS): An Alternative Method for
Quantitative Phosphoproteomics; Klaus Faserl; Martin
Müller; Leopold Kremser; David Teis; Bettina Sarg; Herbert
Lindner; Biocenter, Innsbruck Medical University, Innsbruck,
Austria
ThP 286 Mass Spectrometry-based Quantitative
Phosphoproteomics Identifies Insulin Signaling
Components in C. elegans; James Moresco1; Andrew
Dillin2; John R Yates 3rd1; 1The Scripps Research Institute, La
Jolla, CA; 2University of California, Berkeley, CA
ThP 287 Use of TIQUAS Label-Free Phosphoproteomic
Technology in Drug Profiling and Biomarker Discovery in
Primary Breast Tissue; Iolanda Vendrell1; Marcus Dawson1;
Heather Turner1; Louise Jones2; Bart Vanhaesebroeck1;
Pedro Cutillas1; Neil Torbett1; 1Activiomics Ltd., London, UK;
2
Barts Cancer Institute, London, UK
ThP 288 Discovery of Colon Cancer Metastasis Biomarkers
by Quantitative Phosphoproteomics; Alissa Schunter;
Amanda B Hummon; University of Notre Dame, South Bend,
IN

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ThP 289 Label-free Quantification of Phosphorylation Dynamics
in PDGF Stimulated NIH 3T3 Wild Type and MEK1
Depleted Cell Lines; Laura Edwards; Kyle Grant; Kevin
Blackburn; Jason Haugh; Michael Goshe; North Carolina
State University, Raleigh, NC
ThP 290 Quantitative Phosphoproteomics Analysis of
Alzheimer’s Disease Brains by Multiplexed Isobaric
Labeling; Haiyan Tan; Zhiping Wu; Bing Bai; Xusheng
Wang; Yanji Xu; Junmin Peng; St.Jude Children’s Research
Hospital, Memphis, TN
ThP 291 A Mass Spectrometry Based View at the Origin and
Role of Tyrosine Phosphorylation in Multi-Cellularity;
A.F. Maarten Altelaar1; Jeffrey Ringrose1; Henk van den
Toorn1; Michael Eitel2; Harm Post1; Pieter Neerincx1;
Bernd Schierwater2; Albert Heck1; 1Utrecht University,
Utrecht, Netherlands; 2Tierärztliche Hochschule, Hannover,
Germany
ThP 292 Fuelling the Knowledge of Blood Coagulation Signaling
with Time Resolved Quantitative Phosphoproteomics
of Thrombin-Stimulated Endothelial Cells; Maartje Van
Den Biggelaar1; Juan-Ramon Hernandez2; Alexander B
Meijer1; Koen Mertens1; Sara Zanivan2; 1Sanquin Research,
Amsterdam, The Netherlands; 2Beatson Institute for Cancer
Research, Glasgow, UK
ThP 293 Tyrosine Phosphoproteomics Analysis of Human
Skeletal Muscle; Danjun Ma1; Michael Caruso1; Monique
Lewis1; Xiangmin Zhang1; Zaher Msallaty1; Berhane
Seyoum1; Jeffrey Horowitz2; Zhengping Yi1; 1wayne state
university, Detroit, MI; 2Division of Kinesiology, University of
Michigan, Ann Arbor, MI
ThP 294 Elucidation and Validation of Cell Signaling Activated
by Ischemic Preconditioning in the Rat Myocardium
by Phosphoproteomics: The Role of mTOR; Kiersten
Liddy; Melanie White; Benjamin Parker; Nestor Solis; Brett
Hambly; Stuart Cordwell; The University of Sydney, Sydney,
Australia
ThP 295 Impact of the Degree of Peptide Phosphorylation on
Quantitation by Liquid Chromatography ICP- and ESIMS; Guillaume Ballihaut; W. Clay Davis; NIST, Charleston,
SC
ThP 296 Triple SILAC Phosphoproteomics Reveals Drug Targets
in Multiple Myeloma Cells: A Case for CID over HCD
Using the Orbitrap Elite; Susanne Breitkopf1; Min Yuan1;
John M Asara1, 2; 1Beth Israel Deaconess Medical Center,
Boston, MA; 2Harvard Medical School, Boston, MA
ThP 297 Global Phosphorylation Profiling Reveals Pathways
in Cardio-Protective Signaling Induced by Fibroblast
Growth Factor 2 (FGF2) during Cardiac Ischemia/
Reperfusion Injury; Aruna Wijeratne; Janet Manning; Jo El
Schultz; Ken Greis; University of Cincinnati, Cincinnati, OH
ThP 298 Implementing Multiplexed SID-MRM-MS Assays to
Quantify Phosphorylated Peptides in the DNA Damage
Response Pathway; Jacob Kennedy; Richard Ivey;
Jeffrey Whiteaker; ChenWei Lin; Uliana Voytovich; Amanda
Paulovich; Fred Hutchinson CRC, Seattle, WA
ThP 299 Parallel Reaction Monitoring Assays for
Phosphorylation Sites of AKT Isoforms in PatientDerived Breast Cancer Xenografts with PI3K-AKT
Pathway Aberrations; Matthew Meyer1; Petra ErdmannGilmore1; Kelly V. Ruggles2; Jeanne Rumsey1; Jeremy
Hoog1; Jacqueline Snider1; Robert Kitchens1; Shunqiang Li1;
Sherri R. Davies1; David Fenyo2; Brigitte Simons3; Jason
Held4; Matthew J. Ellis1; R. Robert Townsend1; 1Washington
University School of Medicine, St. Louis, Missouri; 2New
York University, New York, NY; 3AB Sciex, Toronto, CA;
4
Buck Institute, Novarto, CA

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ThP 300 A SILAC-based Phosphoproteomic Analysis of Human
Cervical Cancer Cells upon Staurosporine-induced
Apoptosis; Weitao Jia1, 2; Armann Andaya2; Julie Leary2;
1
Campus Mass Spectrometry Facilities, U.C.Davis, Davis,
CA; 2Dept. of Molecular and Cellular Biology, U.C.Davis,
Davis, CA
ThP 301 Quantification of Phosphorylation on Eukaryotic
Initiation Factors; Armann Andaya; Nancy Villa; Nick
Mahoney; Weitao Jia; Christopher Fraser; Julie Leary; Dept.
of Molecular and Cellular Biology, UC, Davis, CA
ThP 302 Profiling the Phosphoproteome of Healthy Mouse
Brain: From Discovery to Targeted Quantitation; Jenny
M Armenta1; Brad J. Williams1; Erik J. Soderblom2; Brenna
M. Richardson2; Meredith E. Turner2; J. Will Thompson2; M.
Arthur Moseley2; LeRoy Martin1; Michael J. Nold1; 1Waters,
Beverly, MA; 2Duke University Medical Center, Durham, NC
ThP 303 Discovering Immediate-early Events of Hedgehog
Signal Transduction in Tumorigenesis and Cerebellar
Development; Teresa Purzner; Stanford University, Stanford, CA
ThP 304 Capturing Native Protein States in Real-Time Using
a Novel MS Compatible Phosphatase and Protease
Inhibitor Formulation; Jeff Turner; Gordon Nicol; Tina
Kornmeier; Lillian Vickery; Pegah Jalili; John Dapron; Henry
Duewel; Sigma-Aldrich Corporation, St. Louis, MO
ThP 305 Mass Spectrometry Analysis of c-Jun N-Terminal
Kinase-Mediated Mitochondrial Protein Phosphorylation
in Liver Injury; Li-Rong Yu1; Sehwan Jang2; Mohamed
Abdelmegeed2; Yuan Gao1; Atrayee Banerjee2; ByoungJoon Song2; 1National Center for Toxicological Research,
FDA, Jefferson, AR; 2National Institute on Alcohol Abuse
and Alcoholism, Bethesda, MD
ThP 306 PiTRAQ, a Strategy to Simultaneously Correlate
Protein Expression and Phosphorylation Stoichiometry
between Different Samples: Evaluation on Different
Mass Spectrometers; Pieter Glibert1; Maarten Dhaenens1;
Filip Van Nieuwerburgh1; Lennart Martens 2, 3; Dieter
Deforce1; 1Pharmaceutical Biotechnology, Ghent University,
Ghent, Belgium; 2Department of Medical Protein Research,
VIB, Ghent, Belgium; 3Department of Biochemistry, Ghent
University, Ghent, Belgium
Protein: PTM II, 307 – 328
ThP 307 Characterization of Mitochondrial Ubiquitin Substrates
of Parkin and USP30 by Mass Spectrometry; Lilian
Phu; Joy Tea; Christian Cunningham; Daisy Bustos; Corey
E. Bakalarski; Qinghua Song; William F. Forrest; Jacob
Corn; Morgan Sheng; Baris Bingol; Donald S. Kirkpatrick;
Genentech, South San Francisco, CA
ThP 308 Characterization of a Segmentally 15N-Labeled
Branched Ubiquitin Trimer; Yan Wang; Emma Dixon;
Carlos Castaneda; Tanuja Kashyap; David Fushman;
University of Maryland, College Park, MD
ThP 309 Quantitative Assessment of Proteome and
Ubiquitinome Regulation of Skeletal Muscle following
Denervation-Induced Atrophy Using in vivo SILAC;
Sriram Aravamudhan; Thomas Braun; Marcus Krüger;
Max Planck Institute for Heart and Lung Research, Bad
Nauheim, Germany
ThP 310 A Proteomic Investigation of Proteasome
Malfunctioning in Drosophila; Karen Sap; Karel
Bezstarosti; Dick Dekkers; Olaf Voets; Erikjan Rijkers; Peter
Verrijzer; Jeroen Demmers; Erasmus University Medical
Center, Rotterdam, Netherlands
ThP 311 Novel Mass Spectrometry Approach to Reveal
Oxidation-Derived Carbonyl-Groups in vivo; Ralf
Hoffmann; Universität Leipzig, Leipzig, Germany

61ST ASMS CONFERENCE ON MASS SPECTROMETRY

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ThP 312 Development of Mass Spectrometry Sample Preparation
Methods for Localization and Quantitation of Protein
Carbonyls in Biological Matrices; David Simpson; Suresh
Narayanasamy; Lara Lewellyn; Mike Grotewiel; Scott
Gronert; VA Commonwealth University, Richmond, VA
ThP 313 Investigation of Protein Carbonylation in Human Plasma
Collected from Patients with Chronic Kidney Disease
on Dialysis; Chelsea Coffey; Scott Gronert; Virginia
Commonwealth University, Richmond, VA
ThP 314 Streptavidin Affinity Enrichment and Mass
Spectrometric Quantitation of Oxidatively Modified
Drosophila melanogaster Proteins; Suresh
Narayanasamy1; David Simpson1; Lara Lewellyn2; Michael
Grotewiel2; Scott Gronert1; 1Department of Chemistry,
Virginia Commonwealth Uni, Richmond, VA; 2Department of
Human & Molecular Genetics, VCU, Richmond, VA
ThP 315 Protein Ascorbylation of Human Glutaredoxin-1 by a
Reactive Degradation Product of Oxidized Ascorbate;
Klaus Klarskov1; Aurore Flandrin2; Francois-Olivier McDuff1;
Richard J. Wagner1; 1University of Sherbrooke, Sherbrooke,
Canada; 2ENSIAC, Toulouse, France
ThP 316 Mass Spectrometry Based Quantitative Redox
Proteomics in Hypoxic Cardiomyocyte; Kuan-Ting Pan1;
Yi-Yun Chen2; Chun-Yi Yang1; Tzu-Ching Meng1, 2; Kay-Hooi
Khoo1, 2; 1IBS, National Taiwan University, Taipei, Taiwan;
2
Institute of Biological Chemistry, Academia Sinica, Taipei,
Taiwan
ThP 317 Enhanced Protein/Peptide Characterization Using
Electrochemically Assisted Disulfide Bond Reduction;
Jean-Pierre Chervet; Agnieszka Kraj; Hendrik-Jan Brouwer;
Nico Reinhoud; Antec, Zoeterwoude, The Netherlands
ThP 318 Unraveling Modifications of Human Skeletal Muscle
Troponin by Top-down Mass Spectrometry; Yi-Chen
(Ivy) Chen1; Marius Sumandea2; Ying Ge1; 1University
of Wisconsin, Madison, WI; 2Eli Lily and Company,
Indianapolis, IN
ThP 319 Identification and Quantitation of Cysteine Sulfoxidation
Sites; Chia-Fang Lee; Tanya Paull; Maria Person; The
University of Texas, Austin, TX
ThP 320 Site-specific Quantitation Strategy for Characterizing
the Dynamic Change of S-nitrosoproteome and
Glutathionylome; Yi-Ju Chen1; Sheng-Huang Lin2; WenYing Shen2; Yu-Ju Chen1; Chun-Hung Lin2; 1Institute of
Chemistry, Academia Sinica, Taipei City, Taiwan; 2Institute of
Biological Chemistry, Academia Sinica, Taipei City, Taiwan
ThP 321 Iodo-based Labeling Reagent: Permanent Quantitative
Labeling of S-nitrosylation Coupled with Mass
Spectrometry; Heaseung Sophia Chung1; Christopher
Murray1; Ryan Bomgarden2; Vidya Venkatraman1; John
Rogers2; Jennifer Van Eyk1; 1School of Medicine, Johns
Hopkins University, Baltimore, MD; 2Thermo Fisher
Scientific, Rockford, IL
ThP 322 A Novel Method to Detect Protein S-nitrosothiols;
Jaimeen Majmudar; Brent Martin; University of Michigan,
Ann Arbor, Michigan
ThP 323 Post-Translational Nitration and Nitrosylation of
Salivary Proteins Identified by Immunoprecipitation
Coupled with NanoLC-NSI/MS/MS; Wen-Peng Lin; HauhJyun Candy Chen; Natl. Chung Cheng Univ., Chia-Yi,
Taiwan
ThP 324 Impact of Histone Modifications on Global Protein
Expression in Saccharomyces cerevisiae; Linan Wang;
Neha Rastogi; Mark Parthun; Michael A. Freitas; Ohio State
University, Columbus, OH

ThP 325 CID and ETD Based Profiling of Posttranslational
Modifications of Histones in Human Monocyte Derived
Macrophages; Pawel Olszowy1, 2; Pawel Ciborowski1;
1
University of Nebraska Medical Center, Omaha, NE;
2
Nicolaus Copernicus University, Torun, Poland
ThP 326 Novel Language for the Histone Code: Glutamine
Polyaminylation; Chi-Chi Chou1; Cheng-Han Yu2; GeenDong Chang2; Kay-Hooi Khoo1, 2; 1Academia Sinica, Taipei,
Taiwan; 2National Taiwan University, Taipei, Taiwan
ThP 327 Decipher the Histone Code in the Induced Pluripotent
Stem Cell Reprogramming Process; Miao Liu; Changhai
Tian; Hong Peng; Shi-Jian Ding; Univ of Nebraska Med
Center, Omaha, NE
ThP 328 Precursor Ion Scanning for Identification of ADPRibosylation Sites of CD38 Mutants; Robert Sherwood;
Hong Jiang; Xuling Zhu; Qun Liu; Hening Lin; Sheng Zhang;
Cornell University, Ithaca, NY
Glycoproteins II, 329 – 357
ThP 329 MALDI Mass Spectrometry Analysis of Sialylated
Glycoprotein by in Gel Derivatization for Sialic Acids;
Kaoru Kaneshiro; Chikako Hamana; Takashi Nishikaze;
Shin-ichirou Kawabata; Koichi Tanaka; Shimadzu
Corporation, Kyoto, Japan
ThP 330 Enzymatic Sialylation of IgA1 Hinge-Region: Toward
the Understanding of Pathogenic Role of Sialic Acid
in IgA Nephropathy; Kazuo Takahashi1; Milan Raska2;
Milada Horynova-Stuchlova2; Alena Kasperova2; Stacy D.
Hall3; Yoshiyuki Hiki1; Yukio Yuzawa1; Zina Moldoveanu3;
Bruce A. Julian3; Matthew B. Renfrow3; Jan Novak3; 1Fujita
Health University School of Medicine, Toyoake, Japan;
2
Palacky University in Olomouc, Olomouc, Czech Republic;
3
University of Alabama, Birmingham, AL
ThP 331 Glycoform Determination of a Recombinant IgG
Prepared from Transgenic Silkworms; Junko Amano;
Kazuko Hachisu; Takashi Shirai; The Noguchi Institute,
Itabashi, Japan
ThP 332 Anti-citrullinated Protein Antibodies Show IgG-type
Specific Changes Compared to Matched Controls in
Human Serum and Synovial Fluid; Susanna Lundström;
Cátia Cerqueira; Elena Ossipova; Karin Lundberg;
Lars Klareskog; Roman Zubarev; Karolinska Institutet,
Stockholm, Sweden
ThP 333 Characterization of N-linked Glycosylation Sites of
Human Clusterin in Renal Cell Carcinoma Plasma
Samples Using Nano-LC-MS/MS Based Platform;
Francisca Gbormittah1; Fateme Tousi1; Marina Hancapie1;
Shiaw-Lin Wu1; William Hancock1; Othon Iliopoulos2, 3;
1
Barnett Institute, Northeastern University, Boston, MA;
2
Harvard Medical School, Boston, MA; 3Cancer Center,
Massachusetts General Hospital, Boston, MA
ThP 334 Glycoproteomics of Hepatic Metastasis in Colorectal
Cancer; Sheng-Ta Tsai1; Chein-Hung Chen1; Hsin-Yu
Hsieh1; Wei-Chao Chang2; Chung-Hsuan Chen1; 1Genomics
Research Center, Taipei, Taiwan; 2China Medical University,
Taichung, Taiwan
ThP 335 Quantitative N-linked Glycoproteomic Profiling of
Human Induced Pluripotent Cells, Embryonic Stem
Cells, and Somatic Cells; Putty-Reddy Sudhir; Madireddy
Pavana Kumari; Hung-Chih Kuo; Chung-Hsuan Chen;
Genomics Research Center, Academia Sinica, Taipei,
Taiwan
ThP 336 Cell Surface Chemoproteomics for Capturing States
of Cardiac Differentiation from Pluripotent Stem Cells;
Subarna Bhattacharya; Sandra Chuppa; Rebekah Gundry;
Medical College of Wisconsin, Milwaukee, WI

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ThP 337 Mass Spectrometry Characterization of a Novel Form of
the Retinoic Acid Receptor Responder Protein-1; Haeri
Seol; Kristy Brown; Joseph Devaney; Brennan Harmon;
Roger Packer; Yetrib Hathout; Children’s National Medical
Center, Washington, DC
ThP 338 MALDI MS Analysis of N-glycan Structures of a
Cell Adhesion Molecule, CADM1, in Various Cancer
Cells; Mika Sakurai-Yageta1; Tomoko Maruyama1; Kaoru
Kaneshiro2; Sadanori Sekiya2; Shinichi Iwamoto2; Koichi
Tanaka2; Yoshinori Murakami1; 1The University of Tokyo,
Tokyo, Japan; 2Shimadzu Corporation, Kyoto, Japan
ThP 339 Qualitative and Quantitative Investigation of
Glycans Attached to Prostate-specific Antigen (PSA)
Glycoprotein of Healthy and Cancer Samples; Ulrike
Schweiger-Hufnagel1; Kristina Marx1; Daniel Kolarich2;
Wolfgang Jabs1; Anja Resemann1; 1Bruker Daltonik GmbH,
Bremen, Germany; 2Max Planck Institute of Colloids and
Interfaces, Berlin, Germany
ThP 340 Glycosylation Analysis of Cucumicin, a Subtilisin-Like
Serine Protease from Cucumis melo L. Using MALDIQIT-TOF MS; Shuuichi Nakaya1; Yuzo Yamazaki1; Ami
Sotokawauchi3; Yohei Kamijyo3; Kazutaka Murayama2;
Kazunari Arima3; 1Application Development Center,
Shimadzu Corp., Kyoto, Japan; 2Tohoku University, Sendai,
Japan; 3Kagoshima University, Kagoshima, Japan
ThP 341 Determination of Extensive Glycosylation on
Glycoproteins and Glycolipids in High-density
Lipoprotein; Jincui Huang; Hyeyoung Lee; Angela
Zivkovic; Jennifer Smilowitz; Bruce German; Carlito Lebrilla;
UC, Davis, CA
ThP 342 Large Scale Characterization of Intact Sialylated
Glycopeptides Reveals Extensive Plasma Sialylation
and Modulation of Surface Sialylation upon EGF
Stimulation; Peter Højrup; Sara Eun Lendal; Giuseppe
Palmisano; Martin R. Larsen; Univ. Southern Denmark,
Odense, Denmark
ThP 343 MRM Quantification of Site-Specific Core-Fucosylation
of Potential Biomarkers in Liver Diseases; Haidi Yin;
Zhenxin Lin; Andy Lo; Jianhui Zhu; David M. Lubman;
Uiversity of Michigan, Medical School, Ann Arbor, MI
ThP 344 Label-free Quantification of Site-Specific CoreFucosylation of alpha-2-macroglobulin in Pancreatic
Diseases; Zhenxin Lin; Haidi Yin; Andy Lo; David M.
Lubman; University of Michigan, Ann Arbor, MI
ThP 345 Mass Spectrometry Identification of CoImmunoprecipitated N-linked Glycoproteins from Rat
Brain in vivo; Norelle Wildburger1, 2; Cheryl Lichti1; Mark
Emmett3, 4; Carol Nilsson1, 3; 1Department of Pharmacology
& Toxicology, Galveston, TX; 2Neuroscience and Cell
Biology, Galveston, TX; 3Sealy Cancer Center, Galveston,
TX; 4Department of Biochemistry and Molecular Biology,
Galveston, TX
ThP 346 Targeted Glycoproteomic Analysis of Serum
Glycoproteins Enables Site-Specific Glyco-Biomarker
Discovery; Serenus Hua1; Injung Ji1; Myung Jin Oh1;
Sung-Hyeon Lee2; Rudolf Grimm1, 3; Jung Hoe Kim2; Hyun
Joo An1; 1Chungnam National University, Daejeon, Korea;
2
Korea Advanced Institute of Science and Technology,
Daejeon, Korea; 3Agilent Technologies, Santa Clara, CA
ThP 347 HCD Product Ion Triggered ETD MS/MS Facilitates
the Detection of O-GlcNAc Modified Residues of
Insulin Receptor Substrate 2; Lashanda Waller; Jennifer
Rutherford Bethard; Mary Berkaw; Lauren Ball; Medical
Univ of S Carolina, Charleston, SC
ThP 348 High Efficiency LC/MS Analysis of O-GlcNAc Modified
Synthetic Peptides; Barry Boyes1, 2; Alex Harvey3; Ron
Orlando2; 1Advanced Materials Technology Inc, Wilmington,

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ThP 349

ThP 350

ThP 351

ThP 352

ThP 353

ThP 354

ThP 355

ThP 356

ThP 357

DE; 2Complex Carbohydrate Research Center, Athens, GA;
3
Glycoscientific, Athens, GA
Analysis of GalNAc-transferase Site-Specificity
by ETD Tandem Mass Spectrometry; Tyler Stewart;
Kazuo Takahashi; Koshi Yamada; Milan Raska; Milada
Stuchlova Horynova; Jan Novak; Matthew Renfrow; UAB,
Birmingham, AL
Entamoeba O-phosphodiester-linked Glycans and
Phosphopeptides Studied with Mass Spectrometry;
Edwin M. Motari1; John R. Haserick1, 3; Andrea Carpentieri2;
Catherine E. Costello3, 4; Philips W. Robbins1; John
Sameulson1; 1Boston University School of Dental Medicine,
Boston, MA; 2Università di Napoli Federico II, Napoli, Italy;
3
Boston University School Medicine, Boston, MA; 4Boston
University, Boston, MA
MS-based Characterization of Site-specific Protein
O-glycosylations by Combining Glycan Release and
Non-release Methods; Shu-Hui Chen; Li-Juan Huang;
National Cheng Kung University, Tainan, Taiwan
Simultaneous Mapping of N- and O-linked Glycosylation
Sites in Renal Cell Carcinoma Cells; Xiaoying Ye; DaRue
A. Prieto; Josip Blonder; SAIC-Frederick, Inc., Frederick, MD
High Performance Ultraviolet Photodissociation of
O-Linked Glycopeptide Anions in an Orbitrap Mass
Spectrometer; Scott A. Robotham; Jennifer S. Brodbelt;
University of Texas, Austin, TX
MS3 (MRM3) Quantitative O-glycopeptide Analysis;
Miloslav Sanda; Julius Benicky; Radoslav Goldman;
Georgetown University, Lombardi Cancer Center,
Washington, DC
O-linked Glycopeptide Analysis by Automated Scoring
of ETD Mass Spectra; Zhikai Zhu; Eden Go; David Hua;
Heather Desaire; Chemistry Department, University of
Kansas, Lawrence, KS
Comprehensive Study of O-linked Glycans of
Erythropoietin; Nannan Tao; Ulrike Schweiger-Hufnagel;
Kristina Marx; Stephanie Kaspar; Anja Resemann; Bruker
Daltonics Inc., Billerica, MA
LC-MS/MS Identification of the O-Glycosylation and
Hydroxylation of Amino Acid Residues of Collagen α-1
(II) chain from Bovine Cartilage; Ehwang Song; Yehia
Mechref; Texas Tech University, Lubbock, TX
Carbohydrates II, 358 – 383

ThP 358 Improved Sensitivity and Sulfate Stability in Mass
Spec Analysis of Highly Sulfated GAGs Using a
Procainamide Label; David Fischler; Joshua S. Sharp;
Complex Carbohydrate Research Center, UGA, Athens, GA
ThP 359 Automated Identification of MS/MS Spectra from
Heparan Sulfate (HS) Glycosaminoglycan; Yulun Chiu;
Rongrong Huang; Ron Orlando; Joshua S. Sharp; CCRC,
University of Georgia, Athens, GA
ThP 360 Separation and Sequencing of a Synthesized HeparinLike Tetramers Library Using Chemical Derivatization
and LC-MS/MS with an In-House Developed Sequencing
Program; Rongrong Huang; Yulun Chiu; Ron Orlando;
Joshua S. Sharp; CCRC, University of Georgia, Athens, GA
ThP 361 A Simple Method for Early Age Phenotype Confirmation
Using Toe Tissue from a Mouse Model of MPS IIIA;
Paul J. Trim; Stephen K. Duplock; Adeline A. Lau; Kim M.
Hemsley; John J. Hopwood; Marten F. Snel; Lysosomal
Diseases Research Unit, SA Pathology, North Adelaide,
Australia
ThP 362 Optimization of Tissue Surface Digestion by
Glycosidase Enzymes; Lilla Turiak; Chun Shao; Joseph
Zaia; Boston University School of Medicine, Boston, MA

61ST ASMS CONFERENCE ON MASS SPECTROMETRY

THURSDAY POSTERS

ThP 363 Development of a Chemical Inkjet Printer and Liquid
Microjunction Extraction Strategy for Improving Mass
Spectrometric Profiling of Glycosaminoglycans on
Tissue Sections; Chun Shao; Lilla Turiak; Yu Huang;
Joseph Zaia; CBMS, Boston University, Boston, MA
ThP 364 Determination of the Effect of Depolymerization
Methods on Highly-Sulfated HS Domains Using LC/
MS; Yang Mao; Yu Huang; Joseph Zaia; Boston University
School of Medicine, Boston, MA
ThP 365 Efficient Electron Detachment Dissociation (EDD) of
Highly Sulfated Heparin Oligosaccharides on an LC
Time Scale; Yu Huang; Xiang Yu; Yang Mao; Cheng Lin;
Joseph Zaia; Boston University School of Medicine, Boston,
MA
ThP 366 Structural Characterization of Chemoenzymatically
Synthesized Longer (dp5-dp11) Heparan Sulfate
Glycosaminoglycans Using Electron Detachment
Dissociation; Yuejie Zhao1; Isaac Agyekum1; John
Muchena1; Yongmei Xu2; Jian Liu2; Lingyun Li3; Robert
Linhardt3; Jon Amster1; 1University of Georgia, Athens, GA;
2
University of North Carolina, Chapel Hill, NC; 3Rensselaer
Polytechnic Institute, Troy, NY
ThP 367 ESI-MS Analysis of Sulfated Glycans Using Ionic Liquid;
Tianjiao Yang; Yehia Mechref; Texas Tech University,
Lubbock, Texas
ThP 368 Confirming the Presence of “Charge-localization
isomers” in the Disulfated GAG-Type Disaccharide; Yoko
Ohashi1; Yuya Otsuka2; Toshikazu Minamisawa2; Takashi
Hirano1; 1The University of Electro.-Communications, Chofu,
Tokyo, Japan; 2Seikagaku Corporation, Tokyo, Japan
ThP 369 Polysaccharide Structures, Containing Charged
Polysulfated/Polycarboxylated Moieties, Elucidated
Using the MASSPEC Algorithm for Analysis of ExactMass ESI Negative Ionization MSMS Data; Marshall M.
Siegel 1; Gary Walker 1; Lingyun Li2; Robert J. Linhardt2;
1
MS Mass Spec Consultants, Fair Lawn, NJ; 2Rensselaer
Polytechnic Institute, Troy, NY
ThP 370 Quantitative Analysis of Oligosaccharides Derived from
Sulfated Glycosaminoglycans by Affinity Purification
and MALDI MS; Chih-Che Wu; Department of Applied
Chemistry, National Chi Nan, Puli, Taiwan
ThP 371 Biomimetic Reagents for Selective Free Radical and
Acid-Base Chemistry of Glycans: Application to Glycan
Structure Determination by Mass Spectrometry; Jinshan
Gao; Daniel Thomas; Chang Ho Sohn; J. L. Beauchamp;
CCE at Caltech, Pasadena, CA
ThP 372 Charge Carrier Effect to the Ionization and
Fragmentation Efficiency of Glycans; Yaping Lin1; ChiaLin Wu1; Chein-Hung Chen1; Jung-Lee Lin1; Pang-Hung
Hsu2; Chung-Hsuan Chen1; 1Academia sinica, Taipei,
Taiwan; 2National Taiwan Ocean University, Keelung,
Taiwan
ThP 373 Statistical Analysis Model for Classifying Stereo
Structures of Oligosaccharides; Y. Melodie Du; Chiharu
Konda; Yu Xia; Zheng Ouyang; Purdue University, West
Lafayette, IN
ThP 374 Collision-Induced Dissociation of Reducing-End
Modified Small Oligosaccharides; Chiharu Konda1;
Tammy Fang2; Jia Ren1; Brad Bendiak2; Yu Xia1; 1Purdue
University, West Lafayette, IN; 2University of Colorado
Denver, Aurora, CO
ThP 375 Glycan Structural Elucidation On A Novel Quadrupole
Dual Cell Linear Ion Trap Orbitrap Hybrid Mass
Spectrometer; Julian Saba1; Shannon Eliuk1; Sergei
Snovida2; 1Thermo Fisher Scientific, San Jose, CA;
2
Thermofisher Scientific, Rockford, IL

ThP 376 Novel Bioinformatics Approaches to Glycan Profiling
in Liquid Chromatography-Mass Spectrometry; ChuanYih Yu1; Yunli Hu2; Anoop Mayampurath1; Yehia Mehcref1,
2
; Haixu Tang1; 1Indiana University, Bloomington, IN; 2Texas
Tech University, Lubbock, TX
ThP 377 Detailed Structural Investigation of Beta-Glucans from
Yeast Cell Walls by Electron-Transfer Dissociation;
Liang Han1; Catherine E. Costello2; 1Boston University,
Boston, MA; 2Boston University School of Medicine, Boston,
MA
ThP 378 Comparison of ETD and ECD for Analysis of
Permethylated Glycans; Mengdi Fan1; Yi Pu1; Catherine
E Costello1, 2; 1Boston University, Boston, MA; 2Boston
University School of Medicine, Boston, MA
ThP 379 Structural Characterization of Singly Charged
Glycan Anions via Electronic Excitation Tandem
Mass Spectrometry; Jordan C. Ernst; Di Gao; Kristina
Hakansson; University of Michigan, Ann Arbor, MI
ThP 380 Ion fragility of Permethylated Glycans and
Glycoconjugates in Hybrid Ion Trap-Fourier Transform
Mass Spectrometers; Ming-Yi Ho; Kay-Hooi Khoo; Institute
of Biological Chemistry, Academia Sinica, Taipei, Taiwan
ThP 381 Linkage and Anomeric Differentiation in
Oligosaccharides by Sequential Fragmentation and
Variable-wavelength Infrared Photodissociation
Fingerprints; Yanglan Tan; Nicolas Polfer; Department of
Chemistry, University of Florida, Gainesville, FL
ThP 382 Determination of Isomeric Oligosaccharides by Photo
Dissociation with Visible Light; Andrea Hahn; Jurgen
Grotemeyer; Christian-Albrechts-Univ, Kiel, Germany
ThP 383 Computer Assisted Algorithm for the Automated
Annotation of Glycosaminoglycan MS/MS; Jiana Duan;
Jon Amster; University of Georgia, Athens, GA
Biomarker Quantitation: Glycans,
Lipids & Metabolites, 384 – 410
ThP 384 Isobaric Protein-Level Labeling for Serum Glycoprotein
Quantification Analysis on an Orbitrap Elite; Song Nie;
Andy Lo; Jianhui Zhu; David M. Lubman; Department of
Surgery, University of Michigan, Ann Arbor, MI
ThP 385 Targeted Quantification of O-Linked Glycosylation
Site for Glycan Distribution Determination; Scott
Peterman1; Amol Prakash1; Julian Saba2; Mary Lopez1;
Jennifer Cushing3; Audra Ann Harget3; Matthew Renfrow3;
1
Thermo Fisher Scientific BRIMS, Cambridge, MA; 2Thermo
Fisher Scientific, San Jose, CA; 3University of Alabama
Birmingham, Birmingham, AL
ThP 386 Identification and Absolute Quantification of Amadoripeptides in Human Plasma as Potential Diabetes Type
2 Biomarkers; Andrej Frolov; Universität Leipzig, Leipzig,
Germany
ThP 387 Evaluation of Lyso-Gb3 Analogues as Novel Biomarkers
for Fabry Disease; Pamela Lavoie; Michel Boutin;
Christiane Auray-Blais; Université de Sherbrooke/CRCCHUS, Sherbrooke, Canada
ThP 388 A Sensitive HILIC-MS/MS Method for Simultaneously
Measuring Carnitine, PalmitoylCarnitine and
StearoylCarinine as Potential Biomarkers of Fatty Acid
β-Oxidation in Mice; Xiaolin Zhang; Xiao Ding; Georgia
Hatzivassiliou; Mark Merchant; Kirsten Messick; Brian Dean;
Genentech, South San Francisco, CA
ThP 389 Quantification of DNA Interstrand Crosslinks Induced
by CENUs in L1210 Cells Using Liquid Chromatography
Electrospray Ionization Tandem Mass Spectrometry; Lili
Li; Xuechai Chen; Guohui Sun; Lijiao Zhao; Rugang Zhong;
Beijing University of Technology, Beijing, China

61ST ASMS CONFERENCE ON MASS SPECTROMETRY						

PAGE 167

GENERAL
INFORMATION
THURSDAY
POSTERS

ThP 390 Quantitation of 8-iso-PGF2α in Human Urine Using
UHPLC-MS-MS; Yongchao Li2; Jeff Dahl1; Jerry White2;
Richard B. van Breemen2; 1Shimadzu, Columbia, MD;
2
University of Illinois College of Pharmacy, Chicago, IL
ThP 391 Detection of Low Levels of Estradiol with the Use
of Micro Flow LC Coupled to a Sensitive Mass
Spectrometer System; Alexandre Wang; Jesse Seegmiller;
Hua-fen Liu; AB SCIEX, Foster City, CA
ThP 392 Monitoring Steroidal Analogues in Clinical and
Environmental Chemistry: One Model for Exposomics;
Anthony Macherone; Melissa Churley; Agilent Technologies,
Wilmington, DE
ThP 393 Determination of 1,25-Dihydroxylvitamine D3(DHD3)
and 1,25-Dihydroxyvitamine D2 (DHD2) in Human
Plasma by Immunoaffinity Extraction, Diels-Alder
Derivatization and Methylamine Adduction LC/MS/
MS; Xiaohua Li; Vincent Windisch; Allan Xu; Keystone
Bioanalytical, North Wales, PA
ThP 394 Quantification of 25-hydroxyvitamin D3 in Rat Serum
Using Derivatization to Enhance LC-MS/MS Sensitivity;
Yinghe Li; Yifan Shi; Meng Fang; Pamela Rogers; Alliance
Pharma, Inc., Malvern, PA
ThP 395 A Quantitative Stable Isotope LC-MS/MS Method to
Measure Niacin in Blood and Plasma; Lulu Yang; Ann
Qin; Allan Jaochico; Justin Ly; YuZhong Deng; Brian Dean;
Xiaorong Liang; Genentech Inc., South San Francisco, CA
ThP 396 Measurement of Serotonin Concentration Changes in
a Rat Osteoporosis Model after Dosing a Bone Growth
Promoter; Elizabeth A. Mahan; Suzie Yeh; Emily Adarayan;
Rena Zhang; Scott Fauty; Han Gerrits; Freek Bourgoudien;
Benno Ingelse; Merck & Co., West Point, PA
ThP 397 Development of a High Throughput Multi-analyte Assay
for the Quantification of Green Tea – Derived Catechins
in Human Plasma; John Bannister; Deborah Mawson;
Keon Jeffery; Phillip Teale; Bob Gray; Phillip Grace; LGC
Health Sciences, Teddington, UK
ThP 398 LC-MS/MS Quantification of Free Desmosines in
Plasma; Tasso Miliotis1; Sven Kjellström2; 1AstraZeneca
R&D Molndal, Molndal, Sweden; 2Biochemistry and
Structural Biology, Lund, Sweden
ThP 399 Development of an in vivo Quantitative Assay for
Covalently Modified Serum Albumin: Monitoring
Acetaminophen Toxicity; André LeBlanc; Souade Ben
Haddou; Tze Chieh Shiao; René Roy; Lekha Sleno; UQÀM,
Montréal, Canada
ThP 400 Screening Serum Albumin Adducts of Carcinogenic
Arylamines under Different Proteolytic Digestion
Systems; Lijuan Peng; Robert Turesky; Wadsworth Center,
NYS Department of Health, Albany, NY
ThP 401 Simultaneous Profiling of Sixteen Biomarkers of
Occupational Exposure and Endogenous Metabolites
in Urine; Lucie Rimnacova1; Petr Simek1; Petr Husek1;
Jaroslav Mraz2; 1Biology Centre, Czech Academy of
Sciences, Ceske Budejovice, Czech Republic; 2National
Institute of Public Health, Prague, Czech Republic
ThP 402 A LC-MS/MS Method for Determination of
1-Hydroxypyrene, 3-hydroxybenzo[a]pyrene
and 3-hydroxybenz[a]anthracene: Application to
Biomonitoring of Human Smoke Polycyclic Aromatic
Hydrocarbon Exposure; Hongwei Hou; Xiaotao Zhang;
Wei Xiong; Qingyuan Hu; China National Tobacco Quality
Supervision & Test, Zhengzhou, China
ThP 403 HPLC-ESI--MS/MS Quantification of Urinary Metabolites
of 1,3-butadiene in Smokers to Identify Ethnic
Differences in Metabolism; Srikanth Kotapati1; Lani Park2;
Amanda Esades1; Loic Le Marchand2; Natalia Tretyakova1;

PAGE 168					

University of Minnesota, Minneapolis, MN; 2University of
Hawai’i, Honolulu, HI
Characterization of Aromatic Amine Exposure in U.S.
Smokers and Non-Smokers: NHANES 2005-2006;
Tiffany Seyler; Elizabeth Cowan; Jenny Kim; Rey DeCastro;
Benjamin Blount; Lanqing Wang; CDC, Atlanta, GA
Human Exposure Assessment to the Plasticizer
di(isononyl)cyclohexane-1,2-dicarboxylate (DINCH)
Using Urinary Metabolites Identified in Rats; Manori
Silva; Ella Samandar; James Preau; Antonia Calafat;
Centers for Disease Control and Prevention, Atlanta, GA
Comparative Analysis of Acid, Base and BetaGlucuronidase Hydrolysis of Conjugated
4-aminobiphenyl in Fortified Urine; Jenny G. Kim1, 2;
Elizabeth A. Cowan1; Tiffany H. Seyler1; Lanqing Wang1;
Benjamin Blount1; 1Centers for Disease Control and
Prevention, Atlanta, GA; 2ORISE, Oak Ridge, TN
Long Term Stability of Volatile Nitrosamines in Human
Urine; James Hodgson1, 2; Tiffany Seyler2; Lanqing Wang2;
1
Oak Ridge Institute for Science and Education, Oak Ridge,
TN; 2Centers for Disease Control and Prevention, Atlanta,
GA
LC-MS/MS Analysis of Mercapturic Acids: Addressing
Selectivity and Matrix Effect Issues; Alan Dzerk;
Veniamin Lapko; Ridha Nachi; Kirk Newland; Curtis
Sheldon; Celerion, Inc, Lincoln, NE
Rapid Quantitation of Diastereomeric CEdG-A Potential
Biomarker for Diabetes in Human Urine by LC-MS/MS;
Jing Ke1; Kelly Lam1; Yijin Xiao1; Harry Zhao1; Zhongping
(John) Lin1; Daniel Tamae2; Gerald E. Wuenschell2; John
Termini2; 1Frontage Laboratories, Inc, Exton, PA; 2City of
Hope Medical Center, Duarte, CA
Validation of a Method of Measuring Amino Acids
Composition of Peptides and Proteins by Gas
Chromatography/Mass Spectrometry; Ayat H.
BaniRashaid; Peter de B. Harrington; Glen P. Jackson; Ohio
University, Athens, OH
1

ThP 404

ThP 405

ThP 406

ThP 407

ThP 408

ThP 409

ThP 410

Biomarker Discovery: Cancer and Neuroscience, 411 – 442
ThP 411 Label-free Shotgun Proteomic Characterization of
Laser Capture Microdissected Formalin Fixed Paraffin
Embedded Melanoma Biopsies; Owen E. Branson; John
P. Shapiro; Joseph Markowitz; Sara B. Peters; William
E. Carson III; Michael A. Freitas; Ohio State University,
Columbus, OH
ThP 412 Novel Diagnostic and Prognostic Biomarker Candidates
of Hepatocellular Carcinoma Revealed by a Quantitative
2D-DIGE and Label-Free Proteome Analysis; Wael
Naboulsi1; Dominik Megger1; Thilo Bracht Bracht1; Kristin
Rosowski Rosowski1; Birgit Korte1; Stephanie Tautges1;
Don Marvin Voß1; Michael Kohl1; Maike Ahrens 1; Sacha
Hagemann2; Frank Weber4; Hideo Baba2; Jörg F Schlaak3;
Martin Eisenacher1; Christian Stephan1; Helmut Meyer1;
Barbara Sitek 1; 1MPC, Ruhr-Universität Bochum, Bochum,
Germany; 2Pathologie, Universitätsklinikum Essen, Essen,
Germany; 3Hepatologie, Universitätsklinikum Essen, Essen,
Germany; 4Universitätsklinikum Essen, Essen, Germany
ThP 413 A Study Combining Label-Free Proteomics and
2D-DIGE Revealed Novel Biomarker Candidates for
Cholangiocellular Carcinoma; Juliet Padden1; Dominik
Megger1; Thilo Bracht1; Stephanie Tautges1; Don Marvin
Voss1; Kristin Rosowski1; Birgit Korte1; Michael Kohl1;
Martin Eisenacher1; Hideo A. Baba2; Jörg F. Schlaak3;
Christian Gerges4; Brigitte Schumacher4; Horst Neuhaus4;
Helmut E. Meyer1; Barbara Sitek1; 1Medizinisches ProteomCenter, Ruhr-Universität Bochum, Germany; 2Institut für
Pathologie, Universitätsklinikum Essen, Germany; 3Klinik

61ST ASMS CONFERENCE ON MASS SPECTROMETRY

THURSDAY POSTERS

ThP 414

ThP 415

ThP 416

ThP 417

ThP 418

ThP 419

ThP 420

ThP 421

für Gastroenterologie und Hepatologie, Universitätsklinikum
Essen, Germany; 4Evangelisches Krankenhaus Düsseldorf,
Düsseldorf, Germany
Metabolic Profiling of Hepatocellular Carcinoma and
Hepatitis C Using GC-MS, LC-TOF-MS and LC-MS/
MS methods; Hamid Baniasadi 1; G. A. Nagana Gowda3;
Siwei Wei1; Jeremiah Bowers1; Nicholas Skill2; Mary
Maluccio2; Daniel Raftery1, 3; 1Department of Chemistry,
Purdue University, West Lafayette, IN; 2Department of
Surgery, Indiana University, Indianapolis, IN; 3University of
Washington, Seattle, WA
Investigation into the Mechanisms of Prostate Cancer
Androgen Independence Using Label-Free DataIndependent Quantitative LC-IM-DIA-MS and Pathway
Analysis; Brian Morrisey1; Robert Tonge2; Lee A Gethings2;
Johannes PC Vissers2; Stephen Pennington1; 1UCD Conway
Institute, University College Dublin, Dublin, Ireland; 2Waters
Corporation, Manchester, UK
Development of a 4 Protein Signature that Predicts
Outcome to Tamoxifen Treatment in Recurrent Estrogen
Receptor Positive Breast Cancer; Tommaso De Marchi1;
Ning Qing Liu1; Christoph Stingl1; Marcel Smid1; Maxime
Look1; Rene Braakman1; Mark Opdam2; Sabine Linn2; Fred
Sweep3; Paul Span3; John Martens1; John Foekens1; Arzu
Umar1; 1Erasmus University Medical Center, Rotterdam, The
Netherlands; 2Netherlands Cancer Institute, Amsterdam,
The Netherlands; 3Radboud University Nijmegen Medical
Center, Nijmegen, The Netherlands
A Proteomics Profile Associated with Neoadjuvant
Chemotherapy Sensitivity in Triple-Negative Breast
Cancer; Rene Braakman1, 3; Christoph Stingl1; Lennart
Mulder2, 3; Marcel Smid1; Esther Lips2, 3; John Martens1,
3
; Theo Luider1; Sjoerd Rodenhuis2, 3; John Foekens1, 3;
Arzu Umar1, 3; 1Erasmus Medical Center, Rotterdam, The
Netherlands; 2Netherlands Cancer Institute, Amsterdam,
The Netherlands; 3Center for Translational Molecular
Medicine, Eindhoven, The Netherlands
Genome Wide Proteomics of ERBB2 and EGFR
Pathways in Inflammatory Breast Cancer; Yue Zhang1;
Massimo Cristofanilli2; Fredika Robertson3; James Reuben3;
Zhaomei Mu2; Hogune Im4; Michael Snyder4; Matan Hofree5;
Trey Ideker5; Gilbert Omenn6; Susan Fanayan7; Seul-Ki
Jeong8; Young-ki Paik8; Shiaw-Lin Wu1; William Hancock1;
1
Barnett Institute, Northeastern University, Boston, MA;
2
Thomas Jefferson University, Philadelphia, PA; 3M D
Anderson Cancer Center, Houston, TX; 4Department of
Genetics, Stanford University, Stanford, CA; 5University
of California, La Jolla, CA; 6University of Michigan, Ann
Arbor, MI; 7Macquarie University, Sydney, Australia; 8Yonsei
University, Seoul, Korea
A Novel Proteomic Approach for the Routine Screening
for Ovarian Cancer Using PAP samples; Lewis Pannell1;
Lindsay Schambeau1; Meghan Tanner1; Dean Billheimer2;
Rodney Rocconi1; Michael Finan1; 1Mitchell Cancer Institute,
Mobile, AL; 2University of Arizona, Tucson, AZ
Comparison of Label-Free and SILAC Quantitative
Analysis of Breast Cell Lines Glycoproteomes; TenYang Yen; Alejandro Corona; Roger Yen; Chris AlleyneChin; Leslie Timpe; Bruce Macher; San Francisco State
University, San Francisco, CA
Large-Scale Comparative Proteomic Analysis of Colon
Cancer Cells Isolated from Multiple Patients Using an
Extensive Ion Current –Based Approach; Chengjian Tu;
Jun Li; Shichen Shen; Eslam Nouri-Nigjeh; Wilfrido Mojica;
Jun Qu; University at Buffalo, Buffalo, NY

ThP 422 Validation of Early Serum Biomarkers of Colorectal
Cancer Using Selective Reaction Monitoring Mass
Spectrometry; Melanie M. Ivancic; Amy A. Irving; Jennifer
K. Pleiman; Linda Clipson; William F. Dove; Michael R.
Sussman; University of Wisconsin, Madison, WI
ThP 423 Proteomic Analysis of Perineural Invasion in
Pancreatic Adenocarcinoma Reveals Up-regulation of
Neurosecretory Protein VGF in Invaded Nerves; Richard
Jones1; Wasfi Alrawashdeh2; Ravi Amunugama1; Michael
Ford1; David Allen1; Nilukshi Wijesuriya3; Pedro Cutillas2;
Tatjana Crnogorac-Jurcevic2; 1MS Bioworks, LLC, Ann
Arbor, MI; 2Barts Cancer Institute, QMUL, London, UK;
3
Department of Pathology, Royal London Hospital, London,
UK
ThP 424 Target Proteomic Profiling of Frozen Pancreatic CD24+
Adenocarcinoma Tissues by Immuno-Laser Capture
Microdissection and Nano-LC-MS/MS; Jianhui Zhu; Song
Nie; Jing Wu; David M. Lubman; University of Michigan
Medical Center, Ann Arbor, MI
ThP 425 Global Analysis of the Phosphoproteome of Human
Blasts Reveals Predictive Phosphorylation Markers for
the Treatment of Acute Myeloid Leukemia with AC220;
Christoph Schaab1, 2; Felix Oppermann1; Martin Klammer1;
Heike Pfeifer3; Andreas Tebbe1; Thomas Oellerich3; Jürgen
Krauter4; Mark Levis5; Alexander E. Perl Perl6; Henrik Daub1;
Björn Steffen3; Klaus Godl1; Hubert Serve3; 1Evotec Munich,
Martinsried, Germany; 2Max Planck Institute of Biochemistry,
Martinsried, Germany; 3Department of Medicine, Goethe
University, Frankfurt, Germany; 4Medizinische Hochschule
Hannover, Hannover, Germany; 5Sidney Kimmel
Comprehensive Cancer Center, Baltimore, MD; 6Abramson
Cancer Center, PA
ThP 426 Identification of SLPI as a Progression-Associated
Protein in Oral Pre-Cancerous Lesions by Quantitative
Proteomics of Non-Invasively Collected Brushed
Biopsies; Ya Yang1; Nelson Rhodus2; Frank Ondrey3;
Patricia Fernandes3; YaQin Zhu1; Timothy Griffin4; 19th
People’s Hospital,Shanghai JiaoTong University, Shanghai,
China; 2School of Dentistry, University of Minnesota,
Minneapolis, MN; 3Dept of Otolaryngolo,University
of Minnesota, Minneapolis, MN; 4Department of
BMBB,University of Minnesota, Minneapolis, MN
ThP 427 Rapid Phenotyping Renal Cell Carcinoma from Fine
Needle Aspirates Using DESI-MS; Joseph H Kennedy
1
; Matthew T Olson2; Justin M Wiseman1; 1Prosolia, Inc.,
Indianapolis, IN; 2The John Hopkins Hospital, Baltimore, MD
ThP 428 CD180 : A New Marginal Zone B-cell Lymphoma
Biomarker Discovered by Plasma Membrane
Microparticle Proteomic Analysis; Sarah Lennon1;
Laurent Miguet2; Christine Carapito1; Luc Fornecker1;
Laurent Mauvieux2; Alain Van Dorsselaer1; Sarah
Cianférani-Sanglier1; 1Laboratoire de Spectrométrie
de Masse Bioorganique, Strasbourg, France; 2Institut
d’hématologie et d’immunologie, Strasbourg, France
ThP 429 Screening Biomarkers of Thyroid Cancer by a
Combination of Tissue Imaging and Serum Metabolites
Profiling Using MALDI-FTICR MS; Shuai Guo; Hui
Liu; Yumei Guo; Yaping Zhang; Fang Li; Zhili Li; IBMS,
CAMS&PUMC, Beijing, China
ThP 430 Selective Sampling Strategy and Quantitative
Proteomic Analysis Reveals New Mechanisms of
Oxygen-Regulated Solid Tumor Growth in Mouse
Model; Shujia Dai1; Dmitriy Lukashev2; Somak Ray1; Barry
Karger1; Michail Sitkovsky2; 1Barnett Institute, Northeastern
University, Boston, MA; 2Bouve College of Health Sciences
Northeastern Univ, Boston, MA

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GENERAL
INFORMATION
THURSDAY
POSTERS

ThP 431 Quantitative Proteomic Analysis Reveals a Molecular
Triad Signature as Biomarker Candidates for
Astrocytomas and Oligodendrogliomas; Jose Cesar
Rosa4; Suely Kazue Nagahashi Marie1; Sueli Oba-Shinjo1;
João Bosco de Oliveira2; Andreia Otake3; Roger Chammas3;
Clarice Izumi4; Anelisa Ramao4; Helen Julie Laure4; Marcela
Gimenez4; 1Dept. of Neurology, Medical School of Sao
Paulo, Sao Paulo, Brazil; 2Dept. of Laboratory Medicine,
Clinical Center, NIH, Besthesda, MD; 3Experimental
Oncology, Medical School of Sao Paulo, Sao Paulo, Brazil;
4
Cell & Molecular Biology, FMRP-Univ.Sao Paulo, Ribeirao
Preto, Brazil
ThP 432 CSF Proteome Characterisation: Dynamics of Plasma
Proteins and CNS Specific Proteins; Jill Anette Opsahl1,
2
; Elise Aasebø2; Yngvild Bjørlykke 2; Hilde Garberg 1; Astrid
Guldbrandsen2; Frode S. Berven1, 2; 1Proteomics Unit at
University of Bergen, Bergen, Norway; 2The KG Jebsen
Centre for MS-Research, Bergen, Norway
ThP 433 Comparison of Cuprizone and Experimental
Autoimmune Encephalomyelitis Multiple Sclerosis
Models Using TMT and Label-Free Quantitative
Proteomics and Translation to Patients; Eystein
Oveland2, 3; Stig Wergeland1, 3; Harald Barsnes1, 2; KjellMorten Myhr1, 3; Lars Bø1, 3; Frode Berven2, 3; 1University of
Bergen, Bergen, Norway; 2Proteomics Unit at University of
Bergen, Bergen, Norway; 3Haukeland University Hospital,
Bergen, Norway
ThP 434 Selection and Quantification of Neurotrauma Markers in
Cerebrospinal Fluid (CSF) by Mass Spectrometry; Sean
Shen; Ina Wanner; Gregg Czerwieniec; Joseph A. Loo;
University of California, Los Angeles, CA
ThP 435 Using Neuroblastoma as an Alzheimer’s Disease Model
to Study the Effect of Angiotensin Converting Enzyme
Inhibitors; Yu-Chang Tyan 1; Ming-Hui Yang2; 1Kaohsiung
Medical University, Kaohsiung, Taiwan; 2National Yunlin
University of Science & Technology, Yunlin, Taiwan
ThP 436 MALDI-TOF MS Investigation of Analyte Release from
Regions of the Mammalian Peripheral Sensory-Motor
System; Stanislav Rubakhin1; Jonathan Sweedler2;
1
Beckman Institute, UIUC, Urbana, IL; 2Department of
Chemistry, UIUC, Urbana, IL
ThP 437 Proteomic Investigation of Saliva from Children with
Autism Spectrum Disorder (ASD) and Matched Controls
during Circadian Rhythmicity; Katherine M. Beglinger1;
Armand G. Ngounou Wetie1; Kelly L. Wormwood1; Jarrod
W. Mattingly1; Urmi Roy1; Jeanne P. Ryan2; Alisa G.
Woods1; Costel Darie1; Sokolowska Sokolowska1; 1Clarkson
University, Potsdam, NY; 2State University of New York,
Plattsburgh, NY
ThP 438 A TransOmics study of the Saliva of Children with
Autism Spectrum Disorder Using High Definition Mass
Spectrometry; Alisa G. Woods1; Joanne B. Connolly 2; Lee
Gethings2; Armand G. Ngounou Wetie1; Cristian Cojocariu2;
Janet Hammond2; Jeanne P. Ryan3; Costel C. Darie1;
1
Clarkson University, Potsdam, NY; 2Waters, Manchester,
UK; 3State University of New York, Plattsburgh, NY
ThP 439 Proteomic Investigation of Sera and Saliva from
Children with Autism Spectrum Disorder and Matched
Controls; Kelly L. Wormwood1; Armand G. Ngounou
Wetie1; Izabela Sokolowska1; Katherine M. Beglinger1;
Jarrod W. Mattingly1; Urmi Roy1; Jeanne P. Ryan2; Alisa G.
Woods1; Costel Darie1; 1Clarkson University, Potsdam, NY;
2
State University of New York, Plattsburgh, NY
ThP 440 Proteomic Quantification of Characteristic Markers of
Human Oligodendrocyte Differentiation; Raghothama
Chaerkady 1; Candace Kerr1, 2; Robert Cole1; 1Johns
Hopkins University, Baltimore, MD; 2Department of
Biochemistry, University of Maryland, Baltimore, MD

PAGE 170					

ThP 441 Quantitative Proteomic Techniques: Exploring Protein
Pathways and Potential Biomarkers in Dorsal Region
of Rat Spinal Cord Associated with Neuropathic Pain;
Ping Sui; Hiroyuki Watanabe; Georgy Bakalkin; Konstantin
Artemenko; Uppsala University, Uppsala, Sweden
ThP 442 Mass Spectrometry-Based Biomarker Discovery:
toward the Development of Fundamental
Neurochemistry Knowledge Essential for the
Development of New Pain Medicines; Floriane Pailleux1,
2
; Pascal Vachon1; Jérôme Lemoine2; Francis Beaudry1;
1
Université de Montréal, Saint-Hyacinthe, Canada;
2
Université de Lyon, Villeurbanne, France
Proteomics: Clinical Applications, 443 – 476
ThP 443 miR-27b-regulated TCTP as a Novel Plasma Biomarker
for Oral Cancer: From Quantitative Proteomics to
Post-Transcriptional Study; Wan-Yu Lo1; Huang-Joe
Wang1; Chih-Wei Chiu2; Sung-Fang Chen2; 1China Medical
University, Taichung, Taiwan; 2National Taiwan Normal
University, Taipei, Taiwan
ThP 444 Direct ESI-LC-MSMS Microorganism Identification
and Monitoring in Endotracheal Samples from VAP
Suspected Patient; Chloé Bardet1; Christelle Compagnon1;
Marie Cécile Ploy2; Jerôme Lemoine3; Marc Rodrigue1;
Tanguy Fortin1; 1Biomerieux, Marcy L’etoile, France;
2
UMR-S 1092, INSERM Université de Limoges, Limoges,
France; 3UMR 5180, CNRS Université de Lyon 1, Lyon,
France
ThP 445 Changes in the Human Hippocampus Proteome during
Alzheimer’s Disease; David C. Hondius1, 2; Roel C. van der
Schors2; Jeroen J.M. Hoozemans1; Pim van Nierop2; Saskia
M. van der Vies1; Ka Wan Li2; Annemieke J.M. Rozemuller1;
August B. Smit2; 1Dept. of Pathology, VU University
Medical Center, Amsterdam, NL; 2Neuroscience Campus
Amsterdam, VU University, Amsterdam, NL
ThP 446 Creating Reference Materials for Clinically-Relevant
Proteins via QconCAT Peptides; Tyler A Zimmerman;
Mark Lowenthal; Meiyao Wang; Karen Phinney; National
Institute of Standards and Technology, Gaithersburg, MD
ThP 447 AUY922 Generates a Proteomic Fingerprint in Leukemia
Cells that is Highly Conserved among Structurally
Diverse Hsp90 Inhibitors; Sudhakar Voruganti 1; Jeff
LaCroix2; Chelsea Rogers1; Janet Rogers1; Liang Sun1;
Robert L. Matts1; Steven D. Hartson1; 1Oklahoma State
University, Stillwater, OK; 2East Central University, Ada, OK
ThP 448 Top-Down Proteomics of Chronic Lymphocytic
Leukemia: A Pilot Project; Emma Doud1; Vivian Bin Liu2, 3;
Shuo Ma2, 3; Steven Rosen2, 3; Paul Thomas1; Neil Kelleher1;
1
Northwestern University, Evanston, Illinois; 2Robert H. Lurie
Comprehensive Cancer Center, Chicago, IL; 3Feinberg
School of Medicine, Chicago, IL
ThP 449 Towards the Mechanism of EGFR Inhibitor Resistance
in Non-Small Lung Cancer Cells; Michael Blank1; Ryan
Bomgarden2; John Rogers2; Ryan Jacobs3; Jason Fong3;
Neelu Puri3; Vlad Zabrouskov1; Rosa Viner1; 1ThermoFisher
Scientific, San Jose, CA; 2Thermo Fisher Scientific,
Rockford, IL; 3University of Illinois at Chicago, Rockford, IL
ThP 450 Proteomic Analysis of Oxidative Stress-Induces
Monocyte Necrosis; Haiping Tang1; Enbing Tian2; Shan
Feng1; Qingtao Wang2; Chongdong Liu2; Haiteng Deng1;
1
Tsinghua University, Beijing, China; 2Chaoyang Hospital
Affiliated to Capital Medical Un, Beijing, China
ThP 451 Oxacillin Resistance Study on Methicillin Resistant
and Susceptible Staphylococcus aureus by Label Free
Quantitative Proteomics; Xiao-Fen Liu1; Ying-Wei Hu1;
Pei-Jing Pai1; Dai-Jie Chen2; Henry Lam1; 1Hong Kong

61ST ASMS CONFERENCE ON MASS SPECTROMETRY

THURSDAY POSTERS

ThP 452

ThP 453

ThP 454

ThP 455

ThP 456

ThP 457

ThP 458

ThP 459

ThP 460

ThP 461

University of Science and Technology, Hong Kong, China;
2
China State Institute of Pharmaceutical Industry, Shanghai,
China
In-depth Characterization of the Cerebrospinal
Fluid Proteome including Glycosylation Patterns
and Molecular Weights as a Resource for Targeted
Proteomics Assays; Astrid Guldbrandsen; Heidrun
Vethe; Yehia Farag; Hilde Garberg; Magnus Berle; Eystein
Oveland; Jill Anette Opsahl; Harald Barsnes; Frode Berven;
University of Bergen, Bergen, Norway
Comparison of Five Serum Depletion or Fractionation
Methods Applied for Clinical Biomarkers Discovery
Studies; Gabriel Mazzucchelli1; Nicolas Smargiasso1;
Dominique Baiwir2; Edouard Louis3; Edwin De Pauw1; MarieAlice Meuwis3; 1MS Lab, GIGA-R, University of Liege, Liege,
Belgium; 2GIGA proteomic facility, Liege, Belgium; 3Dpmt of
Gastroenterology, University Hospital, CHU, Liege, Belgium
Skin Aging - Identification of Protein Factors Secreted
by Human Dermal Fibroblasts Using a Quantitative
Proteome Approach; Daniel Waldera-Lupa1; Gereon
Poschmann1; Faiza Khalfallah2; Fritz Boege2; Kai Stühler1;
1
Heinrich-Heine Universität Düsseldorf, Düsseldorf,
Germany; 2Universitätsklinikum Düsseldorf, Düsseldorf,
Germany
Dried Blood Spot Proteomics: Automated Surface
Sampling and Sample Preparation; Nicholas J.
Martin; Josephine Bunch; Helen J. Cooper; University of
Birmingham, Birmingham, UK
Super-SILAC Based Quantitative Proteomics for
Comparison of Different Acute Myeloid Leukaemia Cell
Lines; Elise Aasebø1; Gro Gausdal2; Olav Mjaavatten1;
Arthur van der Burgh1; Bjørn Tore Gjertsen3; Stein Ove
Døskeland2; Øystein Bruserud3; Frode Selheim1; Frode
S. Berven1; 1Proteomics Unit, IBM, University of Bergen,
Bergen, Norway; 2Department of Biomedicine, University of
Bergen, Bergen, Norway; 3Institute of Medicine, University
of Bergen, Bergen, Norway
Comparative Proteomics of Androgen and Antiandrogen Treatment in Prostate Cells; Arum Park1;
Jiyeong Lee1; Hee-Joung Lim2; Byung Heun Cha1; Tag Keun
Yoo3; HooKeun Lee4; Hee-Gyoo Kang1; 1Eulji University,
Seongnam, Korea; 2Korea University, Seoul, Korea;
3
Department of Urology and Pathology, Eulji University,
Daejeon, Korea; 4Lee Gil Ya Cancer and Diabetes Institute,
Incheon, Korea
Compare the Change of Proteome Profiling in Prostate
Cells by Disulfiram and Bicalutamide Using In-gel
Digestion; Anne Seok1; Hee-Joung Lim2, 3; JuHwan Lee1;
JiYeong Lee1; Sung Hee Hyun4; Jong-Hoon Kim2; Kwang
Ho Kim3; Hee-Gyoo Kang1; 1Eulji University, Seongnam,
Korea; 2Korea University, Seoul, Korea; 3Kairos Co. Ltd,
Seongnam, Korea; 4Department of Biomedical Laboratory
Science, Eulji University, Daejeon, Korea
Sarcomere Protein Expression Studies Suggest
Mutation-Specific Disease Mechanisms in Human
Hypertrophic Cardiomyopathy; Richard Jones1; Michael
Ford1; Ravi Amunugama1; David Allen1; Frank Davis2; Adam
Helms2; Sarah Bartolone2; Sharlene Day2; 1MS Bioworks,
LLC, Ann Arbor, MI; 2University of Michigan, Ann Arbor, MI
The Peptidome and the Degradome of the Juvenile
Idiopathic Arthritis (JIA) Synovial Fluid; Cristina Clement;
Ginger Janow; Myrasol Callaway; Edward Nieves; Steven
Porcelli; Laura Santambrogio; Albert Einstein College of
Medicine, Bronx, NY
Cellular Senescence and an Inflammatory SenescenceAssociated Secretory Phenotype in Human
Preadipocytes; Yi Zhu; Mayo Clinic, Rochester, MN

ThP 462 Top-Down Sequencing via MALDI-ISD for Clinical
Determination of Protein Variants; Roger Theberge;
Christian Heckendorf; Stephen Whelan; Catherine E
Costello; Mark E McComb; Boston University School of
Medicine, Boston, MA
ThP 463 Smooth Muscle Cell TGF-beta Signaling Study and
Multi-Target Quantification upon TGF-beta Stimulation;
Xiaoqian Liu1; Sarah Parker1; Harry (Hal) Dietz1; Brigitte
Simons2; Jennifer Van Eyk1; 1Johns Hopkins University,
Baltimore, MD; 2AB SCIEX, Concord, ON
ThP 464 Clinical Proteomics Improves Subtyping of Pituitary
Adenomas; Jason D Theis; Surendra Dasari; Julie Vrana;
Ken Johnson; Catarina Giannini; Mark Jentoft; Ahmet
Dogan; Mayo Clinic, Rochester, MN
ThP 465 Optimization of Mass Spectrometry-based Detection
of Beta-Amyloid Variants and the Proteome Profiles
from Alzheimer’s Disease Senile Plaques; Ko-Yi Chien;
Ina Caesar; Sam Gandy; Rong Wang; Mount Sinai Medical
Center, New York, NY
ThP 466 Proteome Measurement Repeatability and Depth of
Protein Coverage in Lymphoma Cell Lines; Kenneth L.
Johnson; Carrie J. Heppelmann; Surendra Dasari; Jason
D. Theis; Roman Zenka; H. Robert Bergen, III; Andrew L.
Feldman; Ahmet Dogan; Mayo Clinic, Rochester, MN
ThP 467 Preliminary Large Scale Quantitative Proteomic
Analysis of Bortezomib Resistant Multiple Myeloma;
Zhiping Wu1; Xusheng Wang1; Haiyan Tan1; Megan
Schertzer1; Dharminder Chauhan2; Kenneth Anderson2;
Junmin Peng1; 1ST. Jude, Memphis, TN; 2DanaFarberCancer Institute, Harvard Medical Sch, Boston, MA
ThP 468 Quantitative Proteomics Analysis of Human Central
Memory T Cells for Assessing Protein Expression
Profile of HIV-Infect