BT1056 Btech Syll Biotech R2013 14

User Manual: BT1056

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B.TECH. (FULL-TIME) - BIOTECHNOLOGY
CURRICULUM & SYLLABUS
2013 – 2014
Volume – I
(all courses except open electives)
FACULTY OF ENGINEERING AND TECHNOLOGY
SRM UNIVERSITY
SRM NAGAR, KATTANKULATHUR – 603 203
1 Biotech-2013 SRM (E&T)
STUDENT OUTCOMES
The curriculum and syllabus for B.Tech programs (2013) conform to outcome
based teaching learning process. In general, ELEVEN STUDENT OUTCOMES (a-k)
have been identified and the curriculum and syllabus have been structured in such
a way that each of the courses meets one or more of these outcomes. Student
outcomes describe what students are expected to know and be able to do by the
time of graduation. These relate to the skills, knowledge, and behaviors that
students acquire as they progress through the program. Further each course in
the program spells out clear instructional objectives which are mapped to the
Student outcomes.
The Student outcomes are
(a) An ability to apply knowledge of mathematics, science, and engineering
(b) An ability to design and conduct experiments, as well as to analyze and
interpret data
(c) An ability to design a system, component, or process to meet desired
needs within realistic constraints such as economic, environmental, social,
political, ethical, health and safety, manufacturability, and sustainability
(d) An ability to function on multidisciplinary teams
(e) An ability to identify, formulate, and solve engineering problems
(f) An understanding of professional and ethical responsibility
(g) An ability to communicate effectively
(h) The broad education necessary to understand the impact of engineering
solutions in global, economic, environmental, and societal context
(i) A recognition of the need for, and an ability to engage in life-long learning
(j) A knowledge of contemporary issues
(k) An ability to use the techniques, skills, and modern engineering tools
necessary for engineering practice.
2 Biotech-2013 SRM (E&T)
B.Tech. Bio-Technology
Curriculum – 2013
(Applicable for students admitted from the academic year
2013-14 onwards)
SEMESTER I
Course
Code
Category
Course Name
L
T
P
C
PD1001
G
SOFT SKILLS I
1
0
1
1
MA1011
B
MATRICES AND CALCULUS
3
2
0
4
PY1001
B
PHYSICS
3
0
0
3
PY1002
B
PHYSICS LAB
0
0
2
1
CY1001
B
CHEMISTRY
3
0
0
3
CY1002
B
CHEMISTRY LAB
0
0
2
1
LE1002
G
VALUE EDUCATION
1
0
0
1
CE1001
E
BASIC CIVIL ENGINEERING
2
0
0
2
Courses from Table I
Student shall register for minimum 20 credits in I semester and minimum 20
credits in II semester. However student shall have registered for all the courses
enlisted under Semester I and II as well the courses in Table I by the time the
registration process is complete in II semester.
Keeping this in mind student shall register for the courses in I and II semesters.
Legend:
L- Number of lecture hours per week
T - Number of tutorial hours per week
P - Number of practical hours per week
C - Number of credits for the course
Category of courses:
G - General
B- Basic Sciences
E- Engineering Sciences and Technical Arts
P- Professional Subjects
3 Biotech-2013 SRM (E&T)
Course
Code
Category
Course Name
L
T
P
C
PD1002
G
SOFT SKILLS II
1
0
1
1
MA1012
B
MULTIPLE INTEGRALS AND
DIFFERENTIAL EQUATIONS
3
2
0
4
PY1003
B
MATERIAL SCIENCE
2
0
2
3
CY1003
B
PRINCIPLES OF
ENVIRONMENTAL SCIENCE
2
0
0
2
BT1002
P
HUMAN PHYSIOLOGY AND
HEALTH
2
0
0
2
BT1003
P
CELL BIOLOGY
3
0
0
3
BT1004
P
BIOCHEMISTRY
3
0
0
3
BT1005
P
BIOCHEMISTRY LABORATORY
0
0
4
2
LE1001
G
ENGLISH
1
2
0
2
TABLE I
COURSES WHICH CAN BE REGISTERED FOR EITHER IN I OR II SEMESTER
SEMESTER I / II
Course
Code
Category
Course Name
L
T
P
C
CS1001
G
PROGRAMMING USING
MATLAB
0
1
2
2
ME1001
E
BASIC MECHANICAL
ENGINEERING
2
0
0
2
EE1001
E
BASIC ELECTRICAL
ENGINEERING
2
0
0
2
EC1001
E
BASIC ELECTRONICS
ENGINEERING
2
0
0
2
ME1005
E
ENGINEERING GRAPHICS
0
1
4
3
ME1004
E
WORKSHOP PRACTICE
0
0
4
2
NC1001/NS1001/
SP1001/YG1001
G
*NCC/NSS/NSO/YOGA
0
0
1
1
4 Biotech-2013 SRM (E&T)
*NCC-National Cadet Corps
NSS-National Service Scheme
NSO-National Sports Organization (India)
SEMESTER III
Course
Code
Category
Course Name
L
T
P
C
LE1003/
LE1004/
LE1005/
LE1006/
LE1007
G
GERMAN LANGUAGE PHASE II /
FRENCH LANGUAGE PHASE II/
JAPANESE LANGUAGE PHASE II /
KOREAN LANGUAGE PHASE II /
CHINESE LANGUAGE PHASE II
2
0
0
2
PD1003
G
APTITUDE I
1
0
1
1
CH1051
E
CHEMICAL AND BIOCHEMICAL
PROCESS CALCULATION
3
0
0
3
BT1006
P
LAB SAFETY AND ANALYTICAL
TECHNIQUES
2
0
0
2
BT1008
P
MICROBIOLOGY
3
0
0
3
BT1010
P
IMMUNOLOGY
3
0
0
3
BT1012
P
GENETICS AND CYTOGENETICS
3
0
0
3
BT1007
P
LAB SAFETY AND ANALYTICAL
TECHNIQUES LAB
0
0
2
1
BT1009
P
MICROBIOLOGY LAB
0
0
4
2
BT1011
P
IMMUNOLOGY LAB
0
0
4
2
BT1013
P
CELL BIOLOGY LAB
0
0
4
2
TOTAL
17
0
15
24
Total No. of Contact Hours
32
SEMESTER IV
Course
Code
Category
Course Name
L
T
P
C
LE1008/
LE1009/
LE1010/
LE1011/
LE1012
G
GERMAN LANGUAGE PHASE II /
FRENCH LANGUAGE PHASE II/
JAPANESE LANGUAGE PHASE II /
KOREAN LANGUAGE PHASE II /
CHINESE LANGUAGE PHASE II
2
0
0
2
PD1004
G
APTITUDE II
1
0
1
1
5 Biotech-2013 SRM (E&T)
SEMESTER IV
Course
Code
Category
Course Name
L
T
P
C
MA1034
B
BIO-STATISTICS
4
0
0
4
CH1052
E
CHEMICAL ENGINEERING
PRINCIPLES I – MECHANICAL
OPERATIONS AND MOMENTUM
TRANSFER
3
0
0
3
CH1054
E
CHEMICAL AND BIOCHEMICAL
ENGINEERING
THERMODYNAMICS
3
0
0
3
BT1014
P
MOLECULAR BIOLOGY
3
0
0
3
BT1016
P
ENZYME ENGINEERING AND
TECHNOLOGY
3
0
0
3
BT1017
P
BIOPROCESS PRINCIPLES
3
0
0
3
CH1053
E
CHEMICAL ENGINEERING
PRINCIPLES LAB
0
0
2
1
BT1015
P
MOLECULAR BIOLOGY
LABORATORY
0
0
4
2
BT1018
P
BIOPROCESS AND ENZYME
TECHNOLOGY LABORATORY
0
0
2
1
P
Dep. Elective –I
3
0
0
3
TOTAL
25
0
9
29
Total No. of Contact Hours
34
SEMESTER V
Course
Code
Category
Course Name
L
T
P
C
PD1005
G
APTITUDE III
1
0
1
1
CH1055
E
CHEMICAL ENGINEERING
PRINCIPLES II -HEAT AND MASS
TRANSFER
3
0
0
3
CH1056
E
CHEMICAL ENGINEERING
PRINCIPLES II -HEAT AND MASS
TRANSFER LAB
0
0
2
1
BT1019
P
VECTOR BIOLOGY AND GENE
3
0
0
3
6 Biotech-2013 SRM (E&T)
SEMESTER V
Course
Code
Category
Course Name
L
T
P
C
MANIPULATION
BT1021
P
ANIMAL BIOTECHNOLOGY
3
0
0
3
BT1022
P
PLANT BIOTECHNOLOGY
3
0
0
3
BT1024
P
ENVIRONMENTAL
BIOTECHNOLOGY
3
0
0
3
BT1020
P
VECTOR BIOLOGY AND GENE
MANIPULATION LABORATORY
0
0
4
2
BT1023
P
PLANT BIOTECHNOLOGY
LABORATORY
0
0
4
2
BT1047
P
INDUSTRIAL TRAINING I (Training
to be undergone after IV semester)
0
0
1
1
P
Dep. Elective -II
3
0
0
3
Open Elective I
3
0
0
3
TOTAL
22
0
12
28
Total No. of Contact Hours
34
SEMESTER VI
Course
Code
Category
Course Name
L
T
P
C
PD1006
G
APTITUDE IV
1
0
1
1
BT1026
P
PHARMACEUTICAL
BIOTECHNOLOGY
3
0
0
3
BT1027
P
BIOPROCESS ENGINEERING
3
0
0
3
BT1025
P
ANIMAL BIOTECHNOLOGY LAB
0
0
4
2
BT1028
P
BIOPROCESS ENGINEERING
LABORATORY
0
0
2
1
BT1049
P
MINOR PROJECT
0
0
2
1
P
Dep. Elective III
3
0
0
3
Open Elective II
3
0
0
3
Open Elective III
3
0
0
3
TOTAL
16
0
9
20
Total No. of Contact Hours
25
7 Biotech-2013 SRM (E&T)
SEMESTER VII
Course
Code
Category
Course Name
L
T
P
C
BT1029
P
PROTEIN ENGINEERING AND PROTEOMICS
3
0
0
3
BT1030
P
BIOSEPARATION TECHNOLOGY
3
0
0
3
BT1032
P
ETHICAL ISSUES, RESEARCH
METHODOLOGY, AND INTELLECTUAL
PROPERTY RIGHTS
1
0
0
1
BT1031
P
BIOSEPARATION TECHNOLOGY LAB
0
0
2
1
BT1048
P
INDUSTRIAL TRAINING II (Training to be
undergone after VI semester)
0
0
1
1
P
Dep. Elective IV
3
0
0
3
P
Dep. Elective V
3
0
0
3
TOTAL
13
0
3
15
Total No. of Contact Hours
16
SEMESTER VIII
Course
Code
Category
Course Name
L
T
P
C
BT1050
P
MAJOR PROJECT / PRACTICE SCHOOL
0
0
24
12
TOTAL
0
0
24
12
Total No. of Contact Hours
24
8 Biotech-2013 SRM (E&T)
DEPARTMENT ELECTIVES
Course
Code
Category
Course Name
L
T
P
C
BT1051
P
CANCER BIOLOGY
3
0
0
3
BT1052
P
STEM CELL BIOLOGY
3
0
0
3
BT1053
P
DRUG AND PHARMACEUTICAL
BIOTECHNOLOGY
3
0
0
3
BT1054
P
COMPUTER SIMULATION AND
DRUG DESIGNING
3
0
0
3
BT1055
P
INDUSTRIAL FERMENTATION
TECHNOLOGY
3
0
0
3
BT1056
P
BIOREACTOR DESIGN
3
0
0
3
BT1057
P
FOOD AND BEVERAGE
FERMENTATION TECHNOLOGY
3
0
0
3
BT1058
P
BIOCHEMICAL REACTION
ENGINEERING
3
0
0
3
BT1059
P
BIOREMEDIATION TECHNOLOGY
3
0
0
3
BT1060
P
METAGENOMICS
3
0
0
3
BT1061
P
BIOENERGY
3
0
0
3
BT1062
P
ENVIRONMENTAL MICROBIOLOGY
3
0
0
3
BT1063
P
ANIMAL THERAPEUTICS
3
0
0
3
BT1064
P
TRANSGENIC ANIMALS
3
0
0
3
BT1065
P
VACCINE BIOTECHNOLOGY
3
0
0
3
BT1066
P
MARINE BIOTECHNOLOGY
3
0
0
3
BT1067
P
PHYTOCHEMICAL TECHNIQUES
3
0
0
3
BT1068
P
PLANT HORMONES AND SIGNAL
TRANSDUCTION
3
0
0
3
BT1069
P
PATHOGENESIS-RELATED
PROTEINS IN PLANTS
3
0
0
3
BT1070
P
REGULATION OF GENE
EXPRESSION IN PLANTS
3
0
0
3
BT1071
P
BIOBUSINESS
3
0
0
3
9 Biotech-2013 SRM (E&T)
SUMMARY OF CREDITS
SEMESTERS
Category
I
II
III
IV
V
VI
VII
VIII
Total
%
G
(Excluding open
and
departmental
electives)
6
2
3
3
1
1
16
B
( Excluding open
and
departmental
electives)
12
9
-
4
25
13.89
E
( Excluding open
and
departmental
electives)
7
6
3
7
4
27
15.00
P
( Excluding open
and
departmental
electives)
10
18
12
17
10
09
12
88
48.89
Open Elective
3
6
9
5.00
Dept. Elective
3
3
3
6
15
8.33
Total
25
27
24
29
28
20
15
12
180
100
10 Biotech-2013 SRM (E&T)
SEMESTER – I
PD1001
SOFT SKILLS-I
L
T
P
C
Total Contact Hours - 30
1
0
1
1
Prerequisite
Nil
PURPOSE
To enhance holistic development of students and improve their employability
skills.
INSTRUCTIONAL OBJECTIVES
1.
To develop inter personal skills and be an effective goal oriented team
player.
2.
To develop professionals with idealistic, practical and moral values.
3.
To develop communication and problem solving skills.
4.
To re-engineer attitude and understand its influence on behavior.
UNIT I - SELF ANALYSIS (4 hours)
SWOT Analysis, Who am I, Attributes, Importance of Self Confidence, Self Esteem
UNIT II - ATTITUDE (4 hours)
Factors influencing Attitude, Challenges and lessons from Attitude.
Change Management
Exploring Challenges, Risking Comfort Zone, Managing Change
UNIT III - MOTIVATION (6 hours)
Factors of motivation, Self talk, Intrinsic & Extrinsic Motivators.
UNIT IV - GOAL SETTING (6 hours)
Wish List, SMART Goals, Blue print for success, Short Term, Long Term, Life
Time Goals.
Time Management
Value of time, Diagnosing Time Management, Weekly Planner To do list,
Prioritizing work.
UNIT V - CREATIVITY (10 hours)
Out of box thinking, Lateral Thinking
11 Biotech-2013 SRM (E&T)
Presentation
ASSESSMENT
1. A practical and activity oriented course which has continuous assessment for
75 marks based on class room interaction, activities etc.
2. Presentation – 25 marks
TEXT BOOK
1. INSIGHT, 2012, Career Development Centre, SRM Publications.
REFERENCES
1. Covey Sean, “Seven Habits of Highly Effective Teens”, New York, Fireside
Publishers, 1998.
2. Carnegie Dale, “How to win Friends and Influence People”, New York: Simon
& Schuster, 1998.
3. homas A Harris, “I am ok, You are ok” , New York-Harper and Row, 1972
4. Daniel Coleman, “Emotional Intelligence”, Bantam Book, 2006
PD1001 - SOFT SKILLS-I
Course Designed by
Career Development Centre
1.
Student outcome
a
b
c
d
e
f
g
h
i
j
k
x
x
x
x
2.
Mapping of instructional
objectives with student
outcome
1
2
3
4
3.
Category
General(G)
Basic
Sciences (B)
Engineering
Sciences and
Technical Arts (E)
Professional
Subjects (P)
x
4.
Approval
23rd Meeting of Academic Council, May 2013
12 Biotech-2013 SRM (E&T)
MA1011
MATRICES AND CALCULUS
L
T
P
C
Total No. of Contact Hours =75 Hours
3
2
0
4
(Common to BT, BI, BME, BP, GE, FPE)
Prerequisite
Nil
PURPOSE
To impart analytical ability in solving mathematical problems as applied to the
respective branches of Engineering.
INSTRUCTIONAL OBJECTIVES
1.
To apply advanced matrix knowledge to Engineering problems.
2.
To improve their ability in trigonometry.
3.
To equip themselves familiar with the concepts of Differential calculus
4.
To expose to the concept of integral calculus
5.
To familiarize with the applications of differential and integral calculus
UNIT I - MATRICES (12 hours)
Review types of matrices, properties. Inverse matrix Cramer’s rule for solving a
system of linear equations. – Rank of Matrix – Consistency and Inconsistency of
a system of m linear equations in ‘n’ unknowns –Cayley Hamilton theorem –
Eigen values and Eigen vectors of a real matrix.
UNIT II - TRIGONOMETRY (12 hours)
Review of complex numbers. De Moiver’s theorem and its applications. Expansion
of
sin n , cos nθ θ
in terms of
sin θ
and
cos θ
.Expansion of
tan nθ
in
terms of
tan
.Expansion of
n
sin θ
and
n
cos θ
in terms of sines and
cosines of multiples of
. Hyperbolic functions and inverse hyperbolic functions.
UNIT III - DIFFERENTIAL CALCULUS (12 hours)
Differentiation and Derivatives of simple functions – Successive Differentiation –
Various forms of Algebraic and Trigonometric functions – Problems.
UNIT IV - INTEGRAL CALCULUS (12 hours)
Methods of integration – Definite integrals and its properties-Reduction formula
for
x
ax n n n n m
e x , sin , cos x, sin x cos x
(without proof)-Problems.
13 Biotech-2013 SRM (E&T)
UNIT V - APPLICATIONS OF DIFFERENTIAL CALCULUS & INTEGRAL
CALCULUS (12 hours)
Applications of differential calculus & integral calculus. Tangent & Normal-Radius
of curvature – Velocity and acceleration. Integral calculus – Length & Area.
TEXT BOOKS
1. Kreyszig.E, “Advanced Engineering Mathematics”, 10th edition, John Wiley &
Sons. Singapore, 2012.
2. Ganesan.K, Sundarammal Kesavan, Ganapathy Subramanian.K.S, &
Srinivasan.V, “Engineering Mathematics”, Gamma publications, Revised
Edition, 2013.
REFERENCES
1. Grewal.B.S, “Higher Engg Maths”, Khanna Publications,42nd Edition, 2012.
2. Veerajan.T, “Engineering Mathematics I”, Tata McGraw Hill Publishing Co.,
New Delhi, 5th edition, 2006.
3. Kandasamy.P, etal. “Engineering Mathematics”, Vol.I (4th revised edition),
S.Chand &Co., New Delhi, 2000.
4. Narayanan.S, Manicavachagom Pillay.T.K, Ramanaiah.G, “Advanced
Mathematics for Engineering students”, Volume I (2nd edition),
S.Viswanathan Printers and Publishers, 1992.
5. Venkataraman.M.K, “Engineering Mathematics” – First Year (2nd edition),
National Publishing Co., Chennai, 2000.
MA 1011 MATRICES AND CALCULUS
Course Designed by
Department of Mathematics
1.
Student outcome
a
b
c
d
E
f
g
h
i
j
k
x
x
2.
Mapping of instructional
objectives with student
outcomes
1-5
1-5
3.
Category
General(G)
Basic
Sciences (B)
Engg. Sci.&
Tech. Arts (E)
Professional
Subjects(P)
x
4.
Approval
23rd Meeting of Academic Council, May 2013
14 Biotech-2013 SRM (E&T)
PY1001
PHYSICS
L
T
P
C
Total Contact Hours-45
3
0
0
3
Prerequisite
Nil
1.
To understand the general scientific concepts required for technology
2.
To apply the Physics concepts in solving engineering problems
3.
To educate scientifically the new developments in engineering and
technology
4.
To emphasize the significance of Green technology through Physics
principles
UNIT I - MECHANICAL PROPERTIES OF SOLIDS AND ACOUSTICS (9 hours)
Mechanical properties of solids: Stress-strain relationship – Hooke’s law –
Torsional Pendulum – Young’s modulus by cantilever – Uniform and non-uniform
bending –– Stress-strain diagram for various engineering materials – Ductile and
brittle materials – Mechanical properties of Engineering materials (Tensile
strength, Hardness, Fatigue, Impact strength, Creep) – Fracture – Types of
fracture (Elementary ideas).
Acoustics: Intensity – Loudness – Absorption coefficient and its determination –
Reverberation – Reverberation time – Factors affecting acoustics of buildings and
their remedies – Sources and impacts of noise – Sound level meter – Strategies
on controlling noise pollution – Ultrasonic waves and properties – Methods of
Ultrasonic production (Magnetostriction and Piezoelectric) – Applications of
Ultrasonics in Engineering and medicine.
UNIT II - ELECTROMAGNETIC WAVES, CIRCUITS AND APPLICATIONS (9 hours)
Del operator – grad, div, curl and their physical significances - displacement
current –Maxwell’s equations (derivation) – Wave equation for electromagnetic
waves – Propagation in free space – Poynting theorem – Characteristic of
Transverse electric and magnetic waves – Skin depth – Rectangular and circular
waveguides – High powered vacuum-based cavity magnetrons – Applications
including radars, microwave oven and lighting systems.
15 Biotech-2013 SRM (E&T)
UNIT III - LASERS AND FIBER OPTICS (9 hours)
Lasers: Characteristics of Lasers – Einstein’s coefficients and their relations –
Lasing action – Working principle and components of CO2Laser, Nd-YAG Laser,
Semiconductor diode Laser, Excimer Laser and Free electron Laser – Applications
in Remote sensing, holography and optical switching – Mechanism of Laser
cooling and trapping.
Fiber Optics: Principle of Optical fiber – Acceptance angle and acceptance cone –
Numerical aperture – V-number – Types of optical fibers (Material, Refractive
index and mode) – Photonic crystal fibers – Fiber optic communication – Fiber
optic sensors.
UNIT IV - QUANTUM MECHANICS AND CRYSTAL PHYSICS (9 hours)
Quantum mechanics: Inadequacies of Classical Mechanics – Duality nature of
electromagnetic radiation – De Broglie hypothesis for matter waves –
Heisenberg’s uncertainty principle –Schrödinger’s wave equation – Particle
confinement in 1D box (Infinite Square well potential). Crystal Physics: Crystal
directions – Planes and Miller indices – Symmetry elements – Quasi crystals –
Diamond and HCP crystal structure – Packing factor – Reciprocal lattice –
Diffraction of X-rays by crystal planes – Laue method and powder method –
Imperfections in crystals.
UNIT V - GREEN ENERGY PHYSICS (9 hours)
Introduction to Green energy – Solar energy: Energy conversion by photovoltaic
principle – Solar cells – Wind energy: Basic components and principle of wind
energy conversion systems – Ocean energy: Wave energy – Wave energy
conversion devices – Tidal energy – single and double basin tidal power plants –
Ocean Thermal Electric Conversion (OTEC) – Geothermal energy: Geothermal
sources (hydrothermal, geo-pressurized hot dry rocks, magma) – Biomass:
Biomass and bio-fuels – bio-energies from wastages – Fuel cells: H2O2–
Futuristic Energy: Hydrogen – Methane Hydrates – Carbon capture and storage
(CCS).
* One problem sheet consisting of 10 to 15 problems is to be prepared for
each unit and discussed in the class.
* Few problems based on design considerations related to appropriate
branches of engineering can be incorporated in each problem sheet.
TEXT BOOKS
1. Thiruvadigal.J.D, Ponnusamy.S, Sudha.D. and Krishnamohan. M, “Physics
for Technologists”, Vibrant Publication, Chennai, 2013
2. Dattu R.Joshi, “Engineering Physics”, Tata McGraw- Hill, New Delhi, 2010.
16 Biotech-2013 SRM (E&T)
REFERENCES
1. Wole Soboyejo, “Mechanical Properties of Engineered Materials”, Marcel
Dekker Inc., 2003.
2. Frank Fahy, “Foundations of Engineering Acoustics”, Elsevier Academic
Press, 2005.
3. Alberto Sona, “Lasers and their applications”, Gordon and Breach Science
Publishers Ltd., 1976.
4. David J. Griffiths, “Introduction to electrodynamics”, 3rd ed., Prentice Hall,
1999.
5. Leonard. I. Schiff, “Quantum Mechanics”, Third Edition, Tata McGraw Hill,
2010.
6. Charles Kittel, "Introduction to Solid State Physics", Wiley India Pvt. Ltd, 7th
ed., 2007.
7. Godfrey Boyle, “Renewable Energy: Power sustainable future”, 2nd edition,
Oxford University Press, UK, 2004.
PY1001 PHYSICS
Course Designed by
Department of Physics and Nanotechnology
1.
Student outcome
a
b
c
d
e
f
G
h
i
j
k
x
x
x
x
2.
Mapping of instructional
objectives with student
outcome
1
4
2
3
3.
Category
General (G)
Basic
Sciences (B)
Engineering
Sciences and
Technical Arts (E)
Professional
Subjects(P)
--
x
--
--
4.
Approval
23rd Meeting of Academic Council, May 2013
17 Biotech-2013 SRM (E&T)
PY1002
PHYSICS LABORATORY
L
T
P
C
Total Contact Hours – 30
0
0
2
1
Prerequisite
Nil
PURPOSE
The purpose of this course is to develop scientific temper in experimental
techniques and to reinforce the physics concepts among the engineering students
INSTRUCTIONAL OBJECTIVES
1.
To gain knowledge in the scientific methods and learn the process of
measuring different Physical variables
2.
Develop the skills in arranging and handling different measuring instruments
3.
Get familiarized with experimental errors in various physical measurements
and to plan / suggest on how the contributions could be made of the same
order, so as to minimize the errors.
LIST OF EXPERIMENTS
1. Determination of Young’s modulus of a given material – Uniform / Non-
uniform bending methods.
2. Determination of Rigidity modulus of a given material – Torsion pendulum
3. Determination of dispersive power of a prism – Spectrometer
4. Determination of laser parameters – divergence and wavelength for a given
laser source –laser grating/ Particle size determination using laser
5. Study of attenuation and propagation characteristics of optical fiber cable
6. Calibration of voltmeter / ammeter using potentiometer
7. Construction and study of IC regulation properties of a given power supply
8. Study of electrical characteristics of a solar cell
9. Mini Project – Concept based Demonstration
TEXT BOOKS
1. Thiruvadigal.J.D, Ponnusamy.S, Sudha.D. and Krishnamohan.M, “Physics
for Technologists”, Vibrant Publication, Chennai, 2013
2. Shukla R.K. and Anchal Srivastava, “Practical Physics”, 1st Edition, New Age
International (P) Ltd, New Delhi, 2006.
REFERENCES
1. Souires.G.L, “Practical Physics:” 4th Edition, Cambridge University, UK,
2001.
2. Chattopadhyay.D, Rakshit P. C. and Saha.B, “An Advanced Course in
Practical Physics”, 2nd ed., Books & Allied Ltd., Calcutta, 1990.
18 Biotech-2013 SRM (E&T)
PY1002 PHYSICS LABORATORY
Course Designed by
Department of Physics and Nanotechnology
1.
Student outcome
a
b
c
d
e
f
g
H
i
j
k
x
x
x
2.
Mapping of instructional
objectives with student
outcome
1
3
2
3.
Category
General(G)
Basic
Sciences(B)
Engineering
Sciences and
Technical Arts (E)
Professional
Subjects (P)
--
x
--
--
4.
Approval
23rd Meeting of Academic Council, May 2013
CY1001
CHEMISTRY
L
T
P
C
Total Contact Hours – 45
3
0
0
3
Prerequisite
Nil
PURPOSE
To enable the students to acquire knowledge in the principles of chemistry for
engineering applications
INSTRUCTIONAL OBJECTIVES
1.
The quality of water and its treatment methods for domestic and industrial
applications.
2.
The classification of polymers, different types of polymerizations,
preparation, properties and applications of important polymers and FRPs.
3.
The phase rule and its application to one and two component systems.
4.
The principle, types and mechanism of corrosion and protective coatings.
5.
The classification and selection of lubricants and their applications.
6.
The basic principles, instrumentation and applications of analytical
techniques
UNIT I - WATER TREATMENT (9 hours)
Water quality parameters: Physical, Chemical & Biological significance -
Hardness of water - estimation of hardness (EDTA method) - Dissolved oxygen –
determination (Winkler’s method), Alkalinity - determination - disadvantages of
using hard water in boilers: Scale, sludge formation - disadvantages - prevention
- treatment: Internal conditioning - phosphate, carbon and carbonate conditioning
methods - External: Zeolite, ion exchange methods - desalination - reverse
osmosis and electrodialysis - domestic water treatment.
19 Biotech-2013 SRM (E&T)
UNIT II - POLYMERS AND REINFORCED PLASTICS (9 hours)
Classification of polymers - types of polymerization reactions - mechanism of
addition polymerization: free radical, ionic and Ziegler - Natta - effect of structure
on the properties of polymers - strength, plastic deformation, elasticity and
crystallinity -Preparation and properties of important resins: Polyethylene, PVC,
PMMA, Polyester, Teflon, Bakelite and Epoxy resins - compounding of plastics -
moulding methods - injection, extrusion, compression and calendaring -
reinforced plastics - FRP – Carbon and Glass- applications.
UNIT III - PHASE EQUILIBRIA, LUBRICANTS AND ADHESIVES (9 hours)
Phase rule: Statement - explanation of the terms involved - one component
system (water system only). Condensed phase rule - thermal analysis - two
component systems: simple eutectic, Pb-Ag; compound formation, Zn-Mg.
Lubricants: Classification –solid, semi solid, liquid, emulsion- properties –
selection of lubricants for different purposes, Adhesives: classification-natural,
synthetic, inorganic- Adhesive action - applications.
UNIT IV - CORROSION AND ITS CONTROL (9 hours)
Corrosion: Basic concepts - mechanism of chemical, electrochemical corrosion
- Pilling Bedworth rule – Types of Electrochemical corrosion - galvanic corrosion
- differential aeration corrosion - pitting corrosion - stress corrosion –
Measurement of corrosion (wt. loss method only) - factors influencing corrosion.
Corrosion control: Cathodic protection - sacrificial anodic method - corrosion
inhibitors. Protective coatings: surface preparation for metallic coatings - electro
plating (copper plating) and electroless plating (Nickel plating) - chemical
conversion coatings - anodizing, phosphating & chromate coating.
UNIT V - INSTRUMENTAL METHODS OF ANALYSIS (9 hours)
Basic principles, instrumentation and applications of potentiometry, UV - visible
spectroscopy, infrared spectroscopy, atomic absorption spectroscopy and flame
photometry.
TEXT BOOKS
1. Kamaraj.P & Arthanareeswari.M, “Applied Chemistry”, 9th Edition,
Sudhandhira Publications, 2012.
2. Dara.S.S, “A Text book of Engineering Chemistry”, 10th Edition, S.Chand &
Company Ltd., New Delhi, 2003
20 Biotech-2013 SRM (E&T)
REFERENCES
1. Jain.P.C and Monika Jain, "Engineering Chemistry", Danpat Rai publishing
company (P) Ltd, New Delhi, 2010.
2. Helen P Kavitha, “Engineering Chemistry – I”, Scitech Publications, 2nd
edition, 2008.
CY1001 CHEMISTRY
Course Designed by
Department of Chemistry
1.
Student outcome
a
b
c
d
e
f
g
H
i
j
k
x
x
x
x
x
2.
Mapping of instructional
objective with student
outcome
1-6
1,5
3
2
4
3.
Category
General(G)
Basic
Sciences(B)
Engineering
Sciences and
Technical Arts (E)
Professional
Subjects (P)
--
x
--
--
4.
Approval
23rd Meeting of Academic Council, May 2013
CY1002
CHEMISTRY LABORATORY
L
T
P
C
Total Contact Hours – 30
0
0
2
1
Prerequisite
Nil
PURPOSE
To apply the concepts of chemistry and develop analytical skills for applications in
engineering.
INSTRUCTIONAL OBJECTIVES
1.
To enable the students to understand the basic concepts involved in the
analyses.
LIST OF EXPERIMENTS
1. Preparation of standard solutions
2. Estimation of total, permanent and temporary hardness by EDTA method
3. Conductometric titration - determination of strength of an acid
4. Estimation of iron by potentiometry.
5. Determination of molecular weight of polymer by viscosity average method
6. Determination of dissolved oxygen in a water sample by Winkler’s method
21 Biotech-2013 SRM (E&T)
7. Determination of Na / K in water sample by Flame photometry
(Demonstration)
8. Estimation of Copper in ore
9. Estimation of nickel in steel
10. Determination of total alkalinity and acidity of a water sample
11. Determination of rate of corrosion by weight loss method.
REFERENCES
1. Kamaraj & Arthanareeswari, Sudhandhira Publications “Practical Chemistry”
(work book), 2011.
2. Helen P. Kavitha “Chemistry Laboratory Manual”, Scitech Publications, 2008.
CY1002 CHEMISTRY LABORATORY
Course Designed by
Department of Chemistry
1.
Student outcome
a
b
c
d
e
f
g
h
i
j
k
x
x
x
2.
Mapping of instructional
objective with student
outcome
1
1
1
3.
Category
General (G)
Basic
Sciences(B)
Engineering
Sciences and
Technical Arts(E)
Professional
Subjects(P)
--
x
--
--
4.
Approval
23rd Meeting of Academic Council, May 2013
LE1002
VALUE EDUCATION
L
T
P
C
Total Contact Hours- 15
1
0
0
1
Prerequisite
Nil
PURPOSE
To provide guiding principles and tools for the development of the whole person
recognizing that the individual is comprised of Physical, Intellectual, Emotional
and Spiritual dimensions.
INSTRUCTIONAL OBJECTIVES
1.
To help individuals think about and reflect on different values.
2.
To deepen understanding, motivation and responsibility with regard to making
personal and social choices and the practical implications of expressing them
in relation to themselves, others, the community and the world at large.
3.
To inspire individuals to choose their own personal, social, moral and
spiritual values and be aware of practical methods for developing and
deepening.
22 Biotech-2013 SRM (E&T)
UNIT I - INTRODUCTION (3 hours)
Definition, Relevance, Types of values, changing concepts of values
UNIT II - INDIVIDUAL AND GROUP BEHAVIOUR (3 hours)
Personal values – Self – Strengths (self-confidence, self-assessment, self-
reliance, self-discipline, determination, self-restraint, contentment, humility,
sympathy and compassion, gratitude, forgiveness) Weaknesses (Influences --
Peer pressure, familial and societal expectations, media)
UNIT III - SOCIETIES IN PROGRESS (3 hours)
Definition of society; Units of society; Communities – ancient and modern –
Agents of change – Sense of survival, security, desire for comfort and ease sense
of belonging, social consciousness and responsibility
UNIT IV - ENGINEERING ETHICS (3 hours)
Definition - Societies for engineers – Code of Ethics – Ethical Issues involved in
cross border research -- Ethical and Unethical practices – case studies –
situational decision making
UNIT V - SPIRITUAL VALUES (3 hours)
What is religion? -- Role of religion – Misinterpretation of religion – moral policing
– Consequences -- Religion as spiritual quest – Aesthetics and religion
TEXT BOOK
1. Department of English and Foreign Languages SRM University, “Rhythm of
Life”, SRM Publications, 2013.
REFERENCE
1. Values (Collection of Essays). Published by: Sri Ramakrishna Math,
Chennai-4. 1996.
LE1002 VALUE EDUCATION
Course Designed by
Department of English and Foreign Languages
1.
Student outcome
a
b
c
d
e
F
g
h
i
J
k
x
x
2.
Mapping of instructional
objectives with student
outcome
1-3
1-3
3.
Category
General (G)
Basic
Sciences (B)
Engineering
Sciences and
Technical Arts (E)
Professional
Subjects (P)
x
--
--
--
4.
Approval
23rd Meeting of Academic Council, May 2013
23 Biotech-2013 SRM (E&T)
CE1001
BASIC CIVIL ENGINEERING
L
T
P
C
Total Contact Hours=30
2
0
0
2
Prerequisite
Nil
PURPOSE
To get exposed to the glimpses of Civil Engineering topics that is essential for an
Engineer.
INSTRUCTIONAL OBJECTIVES
1.
To know about different materials and their properties
2.
To know about engineering aspects related to buildings
3.
To know about importance of surveying and the transportation systems
4.
To get exposed to the rudiments of engineering related to dams, water
supply, and sewage disposal
UNIT I - BUILDING MATERILAS (6 hours)
Introduction – Civil Engineering – Materials: Bricks – composition – classifications
– properties –uses. Stone – classification of rocks – quarrying – dressing –
properties –uses. Timber - properties –uses –ply wood. Cement – grades –types
– properties –uses. Steel – types – mild steel – medium steel – hard steel –
properties – uses – market forms. Concrete – grade designation – properties –
uses.
UNIT II - MATERIAL PROPERTIES (6 hours)
Stress – strain – types – Hook’s law – three moduli of elasticity – poisons ratio –
relationship – factor of safety. Centroid - center of gravity – problems in
symmetrical sections only (I, T and channel sections). Moment of inertia, parallel,
perpendicular axis theorems and radius of gyration (definitions only).
UNIT III - BUILDING COMPONENTS (6 hours)
Building – selection of site – classification – components. Foundations –functions
– classifications – bearing capacity. Flooring – requirements – selection – types
– cement concrete marble – terrazzo floorings. Roof – types and requirements.
UNIT IV - SURVEYING AND TRANSPORTATION (6 hours)
Surveying – objectives – classification – principles of survey. Transportation –
classification – cross section and components of road – classification of roads.
Railway – cross section and components of permanent way –functions. Water
way – docks and harbor – classifications – components. Bridge – components of
bridge.
24 Biotech-2013 SRM (E&T)
UNIT V - WATER SUPPLY AND SEWAGE DISPOSAL (6 hours)
Dams – purpose – selection of site – types –gravity dam (cross section only).
Water supply – objective – quantity of water – sources – standards of drinking
water – distribution system. Sewage – classification – technical terms – septic
tank – components and functions.
TEXT BOOKS
1. Raju.K.V.B, Ravichandran.P.T, “Basics of Civil Engineering”, Ayyappa
Publications, Chennai, 2012.
2. Rangwala,S.C, “Engineering Materials”, Charotar Publishing House, Anand,
2012.
REFERENCES
1. Ramesh Babu, “Civil Engineering”, VRB Publishers, Chennai, 2000.
2. National Building Code of India, Part V, “Building Materials”, 2005
3. Surendra Singh, “Building Materials”, Vikas Publishing Company, New Delhi,
1996.
CE1001 - BASIC CIVIL ENGINEERING
Course Designed by
Department of Civil Engineering
1.
Student outcome
a
b
c
d
e
f
g
h
i
j
k
x
x
x
2.
Mapping of instructional
objectives with student
outcome
1-4
1-4
2-4
3.
Category
General (G)
Basic
Sciences (B)
Engineering
Sciences and
Technical Arts (E)
Professional
Subjects (P)
x
4.
Approval
23rd meeting of academic council , May 2013
25 Biotech-2013 SRM (E&T)
SEMESTER – II
PD1002
SOFT SKILLS-II
L
T
P
C
Total Contact Hours – 30
1
0
1
1
Prerequisite
Nil
PURPOSE
To enhance holistic development of students and improve their employability
skills.
INSTRUCTIONAL OBJECTIVES
1.
To develop inter personal skills and be an effective goal oriented team player.
2.
To develop professionals with idealistic, practical and moral values.
3.
To develop communication and problem solving skills.
4.
To re-engineer attitude and understand its influence on behavior.
UNIT I - INTERPERSONAL SKILLS (6 hours)
Understanding the relationship between Leadership Networking & Team work,
Realizing Ones Skills in Leadership, Networking & Team Work, and Assessing
Interpersonal Skills Situation description of Interpersonal Skill.
Team Work
Necessity of Team Work Personally, Socially and Educationally
UNIT II - LEADERSHIP (4 hours)
Skills for a good Leader, Assessment of Leadership Skills
Change Management
Exploring Challenges, Risking Comfort Zone, Managing Change
UNIT III - STRESS MANAGEMENT (6 hours)
Causes of Stress and its impact, how to manage & distress, Understanding the
circle of control, Stress Busters.
Emotional Intelligence
What is Emotional Intelligence, emotional quotient why Emotional Intelligence
matters, Emotion Scales. Managing Emotions.
26 Biotech-2013 SRM (E&T)
UNIT IV - CONFLICT RESOLUTION (4 hours)
Conflicts in Human Relations – Reasons Case Studies, Approaches to conflict
resolution.
UNIT V - DECISION MAKING (10 hours)
Importance and necessity of Decision Making, process of Decision Making,
Practical way of Decision Making, Weighing Positives & Negatives.
Presentation
ASSESSMENT
1. A practical and activity oriented course which has a continuous assessment
for 75 marks based on class room interaction, activities etc.,
2. Presentation - 25 marks
TEXT BOOK
1. INSIGHT, 2009. Career Development Centre, SRM Publications.
REFERENCE
1. Covey Sean, “Seven Habit of Highly Effective Teens”, New York, Fireside
Publishers, 1998.
2. Carnegie Dale, “How to win Friends and Influence People”, New York: Simon
& Schuster, 1998.
3. Thomas A Harris, “I am ok, You are ok”, New York-Harper and Row, 1972
4. Daniel Coleman, “Emotional Intelligence”, Bantam Book, 2006
PD1002 - SOFT SKILLS-II
Course Designed by
Career Development Centre
1.
Student outcome
a
b
c
d
e
f
g
h
i
j
k
x
x
x
x
2.
Mapping of instructional
objectives with student
outcome
1
2
3
4
3.
Category
General(G)
Basic
Sciences(B)
Engineering
Sciences and
Technical Arts(E)
Professional
Subjects(P)
x
4.
Approval
23rd Meeting of Academic Council, May 2013
27 Biotech-2013 SRM (E&T)
MA 1012
MULTIPLE INTEGRALS AND DIFFERENTIAL
EQUATIONS
L
T
P
C
Total No. of Contact Hours - 75
3
2
0
4
(Common to Bio group)
Prerequisite
Nil
PURPOSE
To impart analytical ability in solving mathematical problems as applied to the
respective branches of Engineering.
INSTRUCTIONAL OBJECTIVES
1.
To understand maxima and minima of two and three variables.
2.
To expose to the concepts of Differential equations
3.
To expose to the concepts of Multiple integrals.
4.
To expose to the concept of vector calculus
5.
To expose to the concept of three dimensional analytical geometry.
UNIT I - FUNCTIONS OF SEVERAL VARIABLES (12 hours)
Functions of two variables – partial derivatives – total differentiation – Taylor’s
expansion – maxima and minima of functions of two and three variables -
Jacobians.
UNIT II - DIFFERENTIAL EQUATIONS (12 hours)
Differential equations of first order–Linear equations of second order with
constant coefficients and variable coefficients – method of variation of
parameters.
UNIT III - MULTIPLE INTEGRALS (12 hours)
Double integration in Cartesian and polar coordinates – Change of order of
integration –Triple integration in Cartesian coordinates.
UNIT IV - VECTOR CALCULUS (12 hours)
Review of Vector Algebra.Gradient, divergence and curl – solenoidal, and
irrotational fields – directional derivatives – line integrals – surface integrals –
volume integrals, Integral theorems (without proof) and its applications-cubes
and parallelepipeds only
28 Biotech-2013 SRM (E&T)
UNIT V - THREE DIMENSIONAL ANALYTICAL GEOMETRY (12 hours)
Direction cosines and direction ratios of a line – angle between two lines.
Equation of a plane – equation of straight line – shortest distance between two
skew lines – coplanar lines.
TEXT BOOKS
1. Kreyszig.E, “Advanced Engineering Mathematics”, 10th edition, John Wiley
& Sons. Singapore, 2012.
2. Ganesan.K, Sundarammal Kesavan, Ganapathy Subramanian.K.S, &
Srinivasan.V, “Engineering Mathematics”, Gamma publications, Revised
Edition, 2013.
REFERENCES
1. Grewal B.S, Higher “Engineering Mathematics”, Khanna Publications, 42nd
Edition , 2012.
2. Veerajan.T, “Engineering Mathematics I”, Tata McGraw Hill Publishing Co.,
New Delhi, 5th edition, 2006.
3. Kandasamy.P etal. “Engineering Mathematics”, Vol.I (4th revised edition),
S.Chand &Co., New Delhi, 2000.
4. Narayanan.S, Manicavachagom Pillay.T.K, Ramanaiah.G, “Advanced
Mathematics for Engineering students”, Volume I (2nd edition),
S.Viswanathan Printers and Publishers, 1992.
5. Venkataraman.M.K, “Engineering Mathematics” – First Year (2nd edition),
National Publishing Co., Chennai, 2000.
MA 1012 MULTIPLE INTEGRALS AND DIFFERENTIAL EQUATIONS
Course Designed by
Department of Mathematics
1.
Student outcome
a
b
c
D
E
f
g
h
i
j
k
x
x
2.
Mapping of instructional
objectives with student
outcomes
1-5
1-5
3.
Category
General
(G)
Basic
Sciences (B)
Engg. Sci.&
Tech. Arts (E)
Professional
Subjects(P)
x
4.
Approval
23rd Meeting of Academic Council, May 2013
29 Biotech-2013 SRM (E&T)
PY1003
MATERIALS SCIENCE
L
T
P
C
Total Contact Hours - 60
2
0
2
3
Prerequisite
Nil
PURPOSE
The course introduces several advanced concepts and topics in the rapidly
evolving field of material science. Students are expected to develop
comprehension of the subject and to gain scientific understanding regarding the
choice and manipulation of materials for desired engineering applications.
INSTRUCTIONAL OBJECTIVES
1.
To acquire basic understanding of advanced materials, their functions and
properties for technological applications
2.
To emphasize the significance of materials selection in the design process
3.
To understand the principal classes of bio-materials and their functionalities
in modern medical science
4.
To get familiarize with the new concepts of Nano Science and Technology
5.
To educate the students in the basics of instrumentation, measurement, data
acquisition, interpretation and analysis
UNIT I - ELECTRONIC AND PHOTONIC MATERIALS (6 hours)
Electronic Materials: Fermi energy and Fermi–Dirac distribution function –
Variation of Fermi level with temperature in intrinsic and extrinsic semiconductors
– Hall effect – Dilute Magnetic Semiconductors (DMS) and their applications
Superconducting Materials: Normal and High temperature superconductivity –
Applications.
Photonic Materials: LED – LCD – Photo conducting materials – Photo detectors
– Photonic crystals and applications – Elementary ideas of Non-linear optical
materials and their applications.
UNIT II - MAGNETIC AND DIELECTRIC MATERIALS (6 hours)
Magnetic Materials: Classification of magnetic materials based on spin – Hard
and soft magnetic materials – Ferrites, garnets and magnetoplumbites – Magnetic
bubbles and their applications – Magnetic thin films – Spintronics and devices
(Giant magneto resistance, Tunnel magneto resistance and Colossal magneto
resistance).
Dielectric Materials: Polarization mechanisms in dielectrics – Frequency and
temperature dependence of polarization mechanism – Dielectric loss – Dielectric
waveguide and dielectric resonator antenna – Piezoelectric, pyroelectric and
ferroelectric materials and their applications.
30 Biotech-2013 SRM (E&T)
UNIT III - MODERN ENGINEERING AND BIOMATERIALS (6 hours)
Modern Engineering Materials: Smart materials – Shape memory alloys –
Chromic materials (Thermo, Photo and Electro) – Rheological fluids – Metallic
glasses – Advanced ceramics – Composites.
Bio-materials: Classification of bio-materials (based on tissue response) –
Comparison of properties of some common biomaterials – Metallic implant
materials (stainless steel, cobalt-based and titanium-based alloys) – Polymeric
implant materials (Polyamides, polypropylene, Acrylic resins and Hydrogels) –
Tissue replacement implants – Soft and hard tissue replacements – Skin implants
– Tissue engineering – Biomaterials for organ replacement (Bone substitutes) –
Biosensor.
UNIT IV - INTRODUCTION TO NANOSCIENCE AND NANOTECHNOLOGY(6 hours)
Basic concepts of Nanoscience and Nanotechnology – Quantum wire – Quantum
well – Quantum dot – fullerenes – Graphene – Carbon nanotubes – Material
processing by chemical vapor deposition and physical vapor deposition –
Principle of SEM, TEM, AFM, Scanning near-field optical microscopy (SNOM) –
Scanning ion-conducting microscopy (SCIM) – Potential uses of nanomaterials in
electronics, robotics, computers, sensors, sports equipment, mobile electronic
devices, vehicles and transportation – Medical applications of nanomaterials.
UNIT V - MATERIALS CHARACTERIZATION (6 hours)
X-ray diffraction, Neutron diffraction and Electron diffraction– X-ray fluorescence
spectroscopy – Fourier transform Infrared spectroscopy (FTIR) – Ultraviolet and
visible spectroscopy (UV-Vis) – Thermogravimetric Analysis (TGA) – Differential
Thermal Analysis (DTA) – Differential Scanning Calorimetry (DSC).
PRACTICAL EXPERIMENTS (30 hours)
1. Determination of resistivity and band gap for a semiconductor material – Four
probe method / Post-office box
2. Determination of Hall coefficient for a semiconducting material
3. To study V-I characteristics of a light dependent resistor (LDR)
4. Determination of energy loss in a magnetic material – B-H curve
5. Determination of paramagnetic susceptibility – Quincke’s method
6. Determination of dielectric constant for a given material
7. Calculation of lattice cell parameters – X-ray diffraction
8. Measurement of glucose concentration – Electrochemical sensor
9. Visit to Advanced Material Characterization Laboratory (Optional)
31 Biotech-2013 SRM (E&T)
TEXT BOOKS
1. Thiruvadigal.J.D, Ponnusamy,S..Sudha.D and Krishnamohan.M, “Materials
Sciences”, Vibrant Publication, Chennai, 2013
2. Rajendran.V, “Materials Science”, Tata McGraw- Hill,New Delhi,2011
REFERENCES
1. Rolf E. Hummel, “Electronic Properties of Materials”, 4th ed., Springer, New
York, 2011.
2. Dennis W. Prather, “Photonic Crystals: Theory, Applications, and
Fabrication”, John Wiley & Sons, Hoboken, 2009.
3. James R. Janesick, “Scientific Charge-Coupled Devices”, Published by SPIE
- The International Society for Optical Engineering, Bellingham, Washington,
2001.
4. David M. Pozar, “Microwave Engineering”, 3rd ed., John Wiley & Sons, 2005.
5. Silver.F. and Dillion.C, “Biocompatibility: Interactions of Biological and
Implantable Materials”, VCH Publishers, New York, 1989.
6. Severial Dumitriu, “Polymeric Biomaterials” Marcel Dekker Inc, CRC Press,
Canada 2001.
7. Cao.G, “Nanostructures and Nanomaterials: Synthesis, Properties and
Applications”, Imperial College Press, 2004.
8. Pradeep.T, “A Text Book of Nanoscience and Nanotechnology”, Tata
McGraw Hill, New Delhi, 2012.
9. Sam Zhang, “Materials Characterization Techniques”, CRC Press, 2008.
PY1003 MATERIALS SCIENCE
Course Designed by
Department of Physics and Nanotechnology
1.
Student outcome
a
b
c
d
e
f
g
H
i
j
k
x
x
x
x
x
2.
Mapping of instructional
objectives with student
outcome
1
5
4
2
3
3.
Category
General(G)
Basic
Sciences (B)
Engineering
Sciences and
Technical Arts (E)
Professional
Subjects(P)
--
x
--
--
4.
Approval
23rd Meeting of Academic Council, May 2013
32 Biotech-2013 SRM (E&T)
CY1003
PRINCIPLES OF ENVIRONMENTAL SCIENCE
L
T
P
C
Total Contact Hours - 30
2
0
0
2
Prerequisite
Nil
PURPOSE
The course provides a comprehensive knowledge in environmental science,
environmental issues and the management.
INSTRUCTIONAL OBJECTIVES
To enable the students
1.
To gain knowledge on the importance of environmental education and
ecosystem.
2.
To acquire knowledge about environmental pollution- sources, effects and
control measures of environmental pollution.
3.
To understand the treatment of wastewater and solid waste management.
4.
To acquire knowledge with respect to biodiversity, its threats and its
conservation and appreciate the concept of interdependence.
5.
To be aware of the national and international concern for environment for
protecting the environment.
UNIT I - ENVIRONMENTAL EDUCATION AND ECOSYSTEMS (6 hours)
Environmental education: Definition and objective. Structure and function of an
ecosystem – ecological succession –primary and secondary succession -
ecological pyramids – pyramid of number, pyramid of energy and pyramid of
biomass.
UNIT II - ENVIRONMENTAL POLLUTION (6 hours)
Environmental segments – structure and composition of atmosphere - Pollution –
Air, water, soil , thermal and radiation – Effects – acid rain, ozone layer depletion
and green house effect – control measures – determination of BOD, COD, TDS
and trace metals.
UNIT III- WASTE MANAGEMENT (6 hours)
Waste water treatment (general) – primary, secondary and tertiary stages. Solid
waste management: sources and effects of municipal waste, bio medical waste -
process of waste management.
33 Biotech-2013 SRM (E&T)
UNIT IV- BIODIVERSITY AND ITS CONSERVATION (6 hours)
Introduction: definition - genetic, species and ecosystem diversity – bio diversity
hot spots - values of biodiversity: consumptive use, productive use, social,
ethical, aesthetic and option values - threats to biodiversity: habitat loss, poaching
of wildlife – endangered and endemic species of India, Conservation of
biodiversity: in-situ and ex-situ conservations.
UNIT V- ENVIRONMENTAL PROTECTION (6 hours)
National concern for environment: Important environmental protection acts in
India – water, air (prevention and control of pollution) act, wild life conservation
and forest act – functions of central and state pollution control boards -
international effort – key initiatives of Rio declaration, Vienna convention, Kyoto
protocol and Johannesburg summit.
TEXT BOOKS
1. Kamaraj.P & Arthanareeswari.M, “Environmental Science – Challenges and
Changes”, 4th Edition, Sudhandhira Publications, 2010.
2. Sharma.B.K. and Kaur, “Environmental Chemistry”, Goel Publishing House,
Meerut, 1994.
REFERENCES
1. De.A.K, “Environmental Chemistry”, New Age International, New Delhi, 1996.
2. Helen P Kavitha, “Principles of Environmental Science”, Sci tech
Publications, 2nd Edition, 2008.
CY1003 – PRINCIPLES OF ENVIRONMENTAL SCIENCE
Course Designed by
Department of Chemistry
1.
Student outcome
a
b
c
d
e
f
g
h
i
j
k
x
x
x
x
x
x
2.
Mapping of instructional
objective with student
outcome
5
2
4
1,3
3
2, 5
3.
Category
General(G)
Basic
Sciences(B)
Engineering
Sciences and
Technical Arts (E)
Professional
Subjects(P)
x
--
--
4.
Approval
23rd Meeting of Academic Council, May 2013
34 Biotech-2013 SRM (E&T)
BT1002
HUMAN PHYSIOLOGY AND HEALTH
L
T
P
C
Total No. of Contact Hours - 30
2
0
0
2
Prerequisite
Nil
PURPOSE
To provide a basic understanding of human physiological systems for a better
comprehension of the problems faced by human.
INSTRUCTIONAL OBJECTIVES
1.
To familiarize the students with the basic organization of organisms and
subsequent development to an organ system, and provide students with an
understanding of the function and regulation of the human body and
physiological integration of the organ systems to maintain homeostasis.
2.
The functional aspects of various organ systems will helpful for further
understanding of the cellular and molecular mechanisms of action in health
and disease.
UNIT I - PHYSIOLOGY OF CELLS AND MOLECULES (5 hours)
Functional organization of cell-Physiology of membranes- Signal transduction-
Regulation of gene expression- Action potential- Cellular physiology of skeletal,
cardiac and smooth muscle
UNIT II - CELLULAR PHYSIOLOGY OF THE NERVOUS SYSTEM (5 hours)
Organization and physiology of neurons-Circuits of the central nervous system-
Autonomic nervous system-Neuronal microenvironment
UNIT III - CARDIOVASCULAR AND RESPIRATORY SYSTEMS (7 hours)
Organization of the cardiovascular system-Arteries and veins-Cardiac
electrophysiology-Heart as a pump-Organization of respiratory system-Mechanics
of respiration-Acid/base physiology-Gas exchange in lungs
UNIT IV - GASTROINTESTINAL AND RENAL SYSTEMS (7 hours)
Organization of the GI system-Gastric function-Pancreas and salivary glands-
Hepatobiliary function-Organization of the urinary system-Glomerular filtration and
Renal blood flow-Integration of salt and water balance
UNIT V - ENDOCRINE AND REPRODUCTIVE SYSTEMS (6 hours)
Organization of the endocrine control-Endorine glands-Regulation of endocrine
glands-Male and female reproductive system-Fertilization, pregnancy, and
lactation
35 Biotech-2013 SRM (E&T)
TEXT BOOKS
1. Boron.W.F. and Boulpaep.E.L,“Medical physiology,”, Elsevier, 2005.
2. Khurana, “Essentials of Medical Physiology,” Elsevier India, 2008.
REFERENCE
1. Bruce M. Koeppen and Bruce A. Stanton, “Berne & Levy Physiology,”6th
Updated Edition, Mosby, 2009.
BT1002 HUMAN PHYSIOLOGY AND HEALTH
Course Designed by
Department of Biotechnology
1.
Student outcomes
a
b
c
d
e
f
G
h
i
j
k
x
x
2.
Mapping of instructional
objectives with student
outcomes
1
2
3.
Category
General(G)
Basic
Sciences (B)
Engg. Sci. &
Tech. Arts (E)
Professional
Subjects (P)
x
4.
Broad Area
Bio-
technology
Bioprocess Engineering
Chemical
Engineering
x
--
--
5.
Approval
23rd Meeting of Academic Council, May 2013
BT1003
CELL BIOLOGY
L
T
P
C
Total No. of Contact Hours – 45
3
0
0
3
Prerequisite
Nil
PURPOSE
To provide a basic understanding of human physiological systems for a better
comprehension of the problems faced by humans.
INSTRUCTIONAL OBJECTIVES
1.
To study cell structure and functions of organelles and understand the
mechanism of cellular transport within and outside the cell membrane
2.
To focus on different receptors and model of signaling and introduce the
concept of cell signaling and their role in diseases
UNIT I - AN OVERVIEW OF CELLS AND CELL RESEARCH (9 hours)
Origin and evolution of cells, cells as experimental models, tools of cell biology –
chemistry of cells – molecular composition of cells, central role of enzymes,
metabolic energy, biosynthesis of cell constituents, cell membrane.
36 Biotech-2013 SRM (E&T)
UNIT II - CELL STRUCTURE AND FUNCTION – I (9 hours)
Nucleus, Endoplasmic reticulum, Golgi apparatus and Lysosomes, Bioenergetics
and Metabolism – Mitochondria, Chloroplasts, Peroxisomes.
UNIT III - CELL STRUCTURE AND FUNCTION – II (9 hours)
The cytoskeleton and cell movement, cell surface – transport of small molecules,
Endocytosis, cell –cell interactions-Adhesion junctions-Tight junctions-Gap
junctions- Plasmodesmata
UNIT IV - CELL SIGNALING – CELL REGULATION (9 hours)
Signaling molecules and their receptors, functions, pathways of intracellular signal
transduction – the Cell Cycle –Mitosis and Meiosis –Cell death and cell renewal-
Programmed cell death-Stem cells- Embryonic stem cells and therapeutic cloning.
UNIT X - DISEASES OF CELLS (9 hours)
Epithelial cells and Cancer – Neurobiology and Neurodegenerative diseases
TEXT BOOK
1. Geoffrey M. Cooper and Robert E. Hausman,“The Cell: A Molecular
Approach,” Fifth Edition, ASM Press and Sinauer Associates, 2009.
REFERENCES
1. Channarayappa, “Cell biology,” Universities Press, 2010.
2. Rastogi.S.C, “Cell biology,” New Age International publishers, 2005.
3. Cecie Starr, “Biology: Concepts and applications,” Sixth edition, Thomson,
2006.
BT1003 CELL BIOLOGY
Course Designed by
Department of Biotechnology
1.
Student outcomes
a
b
c
d
e
f
G
h
I
j
k
x
x
2.
Mapping of instructional
objectives with student
outcomes
1
2
3.
Category
General(G)
Basic
Sciences(B)
Engg. Sci. &
Tech. Arts (E)
Professional
Subjects (P)
x
4.
Broad Area
Bio-
technology
Bioprocess
Engineering
Chemical
Engineering
x
--
--
--
5.
Approval
23rd Meeting of Academic Council, May 2013
37 Biotech-2013 SRM (E&T)
BT1004
BIOCHEMISTRY
L
T
P
C
Total No. of Contact Hours – 45
3
0
0
3
Prerequisite
Nil
PURPOSE
To provide an understanding of the functions of various biomolecules and their
metabolism.
INSTRUCTIONAL OBJECTIVES
1.
To study structural and functional properties of carbohydrates, proteins,
lipids and nucleic acids
2.
To emphasize the role of biomolecules by providing basic information on
specific metabolic diseases and disorders
UNIT I - INTRODUCTION TO BIOCHEMISTRY (12 hours)
Introduction-Chemical bonds-pH-Buffers-Carbohydrates-Lipids-Proteins
UNIT II - METABOLISM OF CARBOHYDRATES (8 hours)
Introduction to Metabolism-Glycolysis-Citric acid cycle-Gluconeogenesis-
Glycogen metabolism-Glycogenesis-Glycogenolysis-Biochemical aspects of
Diabetes Mellitus
UNIT III - PROTEIN METABOLISM (9 hours)
Introduction-Metabolism of amino acids-Transamination-Deamination-Metabolism
of ammonia-Urea cycle-Biosynthesis of amino acids-Disorders of tyrosine
(phenylalanine) metabolism
UNIT IV - FATTY ACID METABOLISM AND NUCLEIC ACID METABOLISM
(8 hours)
Introduction-Fatty acid oxidation-Ketone bodies & Ketogenesis-Biosynthesis of
Fatty acids-Eicosanoids-Cholesterol Biosynthesis-Lipoproteins-Disorders of Lipid
metabolism-Nucleic acids: Biosynthesis of Purine and Pyrimidines-Degradation of
purine nucleotides and pyrimidine nucleotides-Disorders of Purine and pyrimidine
metabolism
UNIT V - OXIDATIVE PHOSPHORYLATION (8 hours)
Introduction-Bioenergetics, High energy compounds, Biological oxidation-Electron
transport chain, Oxidative phospholyration, Chemiosmotic theory-Shuttle pathway
– Glycerol phosphate Shuttle, Malate aspartate Shuttle –Shunt pathways
38 Biotech-2013 SRM (E&T)
TEXT BOOKS
1. Jain, J L, Jain, Nitin, Sunjay Jain, “Fundamentals of Biochemistry”, S. Chand
Group, ISBN: 8121924537.
2. Satyanarayana.U & U. Chakrapani, “Biochemistry”,Books and Allied (p) Ltd.,
ISBN: 8187134801.
REFERENCES
1. David L. Nelson, Albert Lester Lehninger, Michael M. Cox, “Lehninger
Principles of Biochemistry”, Edition 5, illustrated, W. H. Freeman, 2008.
2. Jeremy M. Berg, John L. Tymoczko, Lubert Stryer, “Biochemistry”, Ed. 7, W.
H. Freeman, 2012.
BT1004 BIOCHEMISTRY
Course Designed by
Department of Biotechnology
1.
Student outcomes
a
b
c
d
e
f
G
h
i
j
k
x
x
2.
Mapping of instructional
objectives with student
outcomes
1
2
3.
Category
General (G)
Basic
Sciences(B)
Engg. Sci. & Tech.
Arts (E)
Professional
Subjects (P)
x
4.
Broad Area
Bio-
technology
Bioprocess
Engineering
Chemical
Engineering
x
--
--
--
5.
Approval
23rd Meeting of Academic Council, May 2013
BT1005
BIOCHEMISTRY LABORATORY
L
T
P
C
Total No. of Contact Hours – 60
0
0
4
2
Prerequisite
BT 1004
PURPOSE
To establish the basics of practical biochemistry and to provide a platform for
understanding and analyzing the biomolecules
INSTRUCTIONAL OBJECTIVES
1.
To teach laboratory safety and standard operating procedures of common
laboratory equipment’s
2.
To impart skills in preparation of solutions and biological buffers
3.
To extend knowledge in analysis, estimation and comparison of biomolecules
in normal and diseased conditions
4.
To offer exposure on modern separation techniques for biomolecules
39 Biotech-2013 SRM (E&T)
LIST OF EXPERIMENTS
1. Introduction to commonly used instruments (pH meter, Spectrophotometer,
Centrifuge, Microscopes etc..) and laboratory safety
2. pH measurements and preparation of buffers
3. Qualitative analysis of carbohydrates (Monosaccharide – Hexo, Pentose,
Aldo, Keto sugars, Disaccharides – Reducing and non-reducing sugars,
Polysaccharides)
4. Estimation of blood glucose and comparison of normal and diabetes mellitus
samples
5. Estimation of blood plasma proteins
6. Separation of amino acids on Thin layer chromatography
7. Quantification of cholesterol and triglycerides from blood
8. Biochemical estimation of nucleic acid using spectrophotometer
9. HPLC determination of caffeine in urine – Demo
10. Purification of biomolecules using FPLC - Demo
REFERENCE
1. Laboratory Manual
BT1005 BIOCHEMISTRY LABORATORY
Course Designed by
Department of Biotechnology
1.
Student outcomes
a
b
c
d
e
f
g
i
j
k
x
x
x
2.
Mapping of instructional
objective with student
outcomes
1
1
4
3.
Category
General(G)
Basic
Sciences(B)
Engg. Sci. &
Tech. Arts (E)
Professional
Subjects (P)
x
4.
Broad area
Bio-
technology
Bioprocess
Engineering
ChemicalEngineering
x
--
--
5.
Approval
23rd Meeting of Academic Council, May 2013
40 Biotech-2013 SRM (E&T)
LE1001
ENGLISH
L
T
P
C
Total Contact Hours-45
1
2
0
2
Prerequisite
Nil
PURPOSE
To help students achieve proficiency in English and develop their professional
communication skills to meet the demand in the field of global communication to
enable them to acquire placement anywhere with ease and confidence.
INSTRUCTIONAL OBJECTIVES
1.
To enable students improve their lexical, grammatical and communicative
competence.
2.
To enhance their communicative skills in real life situations.
3
To assist students understand the role of thinking in all forms of
communication.
4.
To equip students with oral and appropriate written communication skills.
5.
To assist students with employability and job search skills.
UNIT I - INVENTIONS (9 hours)
1. Grammar and Vocabulary – Tense and Concord:
2. Listening and Speaking – Common errors in Pronunciation (Individual
sounds); Process description (Describing the working of a machine, and the
manufacturing process)
3. Writing – Interpretation of data (Flow chart, Bar chart)
4. Reading -- (Reading Comprehension -- Answering questions)
UNIT II - ECOLOGY (9 hours)
1. Grammar and Vocabulary – Error Analysis – Synonyms and Antonyms,
Parallelisms
2. Listening and Speaking - Conducting Meetings
3. Writing – Notice, Agenda, Minutes , letters to the editor via email : Email
etiquette
4. D Reading Comprehension – Summarizing and Note-making
UNIT III - SPACE (9 hours)
1. Grammar and Vocabulary – tense and concord; word formation
2. Listening and Speaking – Distinction between native and Indian English
(Speeches by TED and Kalam) – accent, use of vocabulary and rendering;
3. Writing – Definitions and Essay writing
4. Reading Comprehension – Predicting the content
41 Biotech-2013 SRM (E&T)
UNIT IV - CAREERS (9 hours)
1. Grammar and Vocabulary –Homonyms and Homophones
2. Listening and Speaking – – Group Discussion
3. Writing .Applying for job, cover letter and resume
4. Reading, etymology (roots; idioms and phrases), Appreciation of creative
writing.
UNIT V - RESEARCH (9 hours)
1. Grammar and Vocabulary – Using technical terms, Analogies
2. Listening and Speaking -- Presentation techniques (Speech by the learner)
3. Writing – Project Proposal
4. Reading Comprehension -- Referencing Skills for Academic Report Writing
(Research Methodology – Various methods of collecting data) Writing a
report based on MLA Handbook
TEXTBOOK
1. Department of English and Foreign Languages. “English for Engineers”, SRM
University Publications, 2013.
REFERENCES
1. Dhanavel.S.P, “English and Communication Skills for Students of Science
and Engineering”,Orient Blackswan Ltd., 2009.
2. Meenakshi Raman and Sangeetha Sharma.“Technical Communication-
Principles and Practice”, Oxford University Press, 2009.
3. Day.R.A, Scientific English: “A Guide for Scientists and Other Professionals”,
2nd ed. Hyderabad: Universities Press, 2000.
LE1001 ENGLISH
Course Designed by
Department of English and Foreign Languages
1.
Student outcome
a
b
c
d
e
f
G
h
i
j
k
x
x
x
x
2.
Mapping of instructional
objectives with student
outcome
1-5
1-5
1-5
1-5
3.
Category
General
(G)
Basic
Sciences (B)
Engineering Sciences
and Technical Arts
(E)
Professional
Subjects (P)
x
--
--
--
4.
Approval
23rd Meeting of Academic Council, May 2013
42 Biotech-2013 SRM (E&T)
SEMESTER I/II
CS1001
PROGRAMMING USING MATLAB
L
T
P
C
Total Contact Hours - 45
0
1
2
2
Prerequisite
Nil
PURPOSE
This Lab Course will enable the students to understand the fundamentals and
programming knowledge in MATLAB.
INSTRUCTIONAL OBJECTIVES
1.
To learn the MATLAB environment and its programming fundamentals
2.
Ability to write Programs using commands and functions
3.
Able to handle polynomials, and use 2D Graphic commands
LIST OF EXPERIMENTS
1. Practicing MATLAB environment with simple exercises to familiarize
Command Window, History, Workspace, Current Directory, Figure window,
Edit window, Shortcuts, Help files.
2. Data types, Constants and Variables, Character constants, operators,
Assignment statements.
3. Control Structures: For loops, While, If control structures, Switch, Break,
Continue statements.
4. Input-Output functions, Reading and Storing Data.
5. Vectors and Matrices, commands to operate on vectors and matrices, matrix
Manipulations.
6. Arithmetic operations on Matrices, Relational operations on Matrices, Logical
operations on Matrices.
7. Polynomial Evaluation, Roots of Polynomial, Arithmetic operations on
Polynomials.
8. Graphics: 2D plots, Printing labels, Grid & Axes box, Text in plot, Bar and Pie
chart.
TEXT BOOK
1. Bansal.R.K, Goel.A.K, Sharma.M.K, “MATLAB and its Applications in
Engineering”, Pearson Education, 2012.
REFERENCES
1. Amos Gilat, “MATLAB-An Introduction with Applications”, Wiley India, 2009.
2. Stephen.J.Chapman, “Programming in MATLAB for Engineers”, Cengage
Learning, 2011.
43 Biotech-2013 SRM (E&T)
CS1001 PROGRAMMING USING MATLAB
Course Designed by
Department of Computer Science and Engineering
1.
Student outcome
a
b
c
d
e
f
g
h
i
j
k
x
x
x
2.
Mapping of instructional
objective with student
outcome
2,3
1-3
1
3.
Category
General(G)
Basic
Sciences(B)
Engineering
Sciences and
Technical Arts (E)
Professional
Subjects(P)
x
--
--
--
4.
Approval
23rd Meeting of Academic Council, May 2013
ME1001
BASIC MECHANICAL ENGINEERING
L
T
P
C
Total Contact Hours - 30
2
0
0
2
Prerequisite
Nil
PURPOSE
To familiarize the students with the basics of Mechanical Engineering.
INSTRUCTIONAL OBJECTIVES
1.
To familiarize with the basic machine elements
2.
To familiarize with the Sources of Energy and Power Generation
3.
To familiarize with the various manufacturing processes
UNIT I - MACHINE ELEMENTS– I (5 hours)
Springs: Helical and leaf springs – Springs in series and parallel. Cams: Types of
cams and followers – Cam profile.
UNIT II - MACHINE ELEMENTS– II (5 hours)
Power Transmission: Gears (terminology, spur, helical and bevel gears, gear
trains). Belt drives (types). Chain drives. Simple Problems.
UNIT III - ENERGY (10 hours)
Sources: Renewable and non-renewable (various types, characteristics,
advantages/disadvantages). Power Generation: External and internal combustion
engines – Hydro, thermal and nuclear power plants (layouts, element/component
description, advantages, disadvantages, applications). Simple Problems.
44 Biotech-2013 SRM (E&T)
UNIT IV - MANUFACTURING PROCESSES - I (5 hours)
Sheet Metal Work: Introduction – Equipments – Tools and accessories – Various
processes (applications, advantages / disadvantages). Welding: Types –
Equipments – Tools and accessories – Techniques employed -applications,
advantages / disadvantages – Gas cutting – Brazing and soldering.
UNIT V - MANUFACTURING PROCESSES– II (5 hours)
Lathe Practice: Types - Description of main components – Cutting tools – Work
holding devices – Basic operations. Simple Problems. Drilling Practice:
Introduction – Types – Description – Tools. Simple Problems.
TEXT BOOKS
1. Kumar.T, Leenus Jesu Martin and Murali.G, “Basic Mechanical Engineering”,
Suma Publications, Chennai, 2007.
2. PrabhuT.J, Jai Ganesh.V and Jebaraj.S, “Basic Mechanical Engineering”,
Scitech Publications, Chennai, 2000.
REFERENCES
1. Hajra Choudhary.S.K and HajraChoudhary.A.K, “Elements of Workshop
Technology”, Vols. I & II, Indian Book Distributing Company Calcutta, 2007.
2. Nag.P.K, “Power Plant Engineering”, Tata McGraw-Hill, New Delhi, 2008.
3. Rattan.S.S, “Theory of Machines”, Tata McGraw-Hill, New Delhi, 2010.
ME1001 BASIC MECHANICAL ENGINEERING
Course Designed by
Department of Mechanical Engineering
1.
Student outcome
a
b
c
d
e
f
g
h
i
j
k
x
x
2.
Mapping of instructional
objectives with student
outcome
1- 3
1- 3
3.
Category
General (G)
Basic
sciences(B)
Engineering
sciences and
technical art (E)
Professional
subjects (P)
--
--
x
--
4.
Approval
23rd Meeting of the Academic Council , May 2013
45 Biotech-2013 SRM (E&T)
EE1001
BASIC ELECTRICAL ENGINEERING
L
T
P
C
Total Contact Hours - 30
2
0
0
2
Prerequisite
Nil
PURPOSE
This course provides comprehensive idea about circuit analysis, working
principles of machines and common measuring instruments.
INSTRUCTIONAL OBJECTIVES
1.
Understand the basic concepts of magnetic circuits, AC & DC circuits.
2.
Explain the working principle, construction, applications of DC & AC
machines and measuring instruments.
3.
Gain knowledge about the fundamentals of wiring and earthling
UNIT I - FUNDAMENTALS OF DC CIRCUITS (6 hours)
Introduction to DC and AC circuits, Active and passive two terminal elements,
Ohms law, Voltage-Current relations for resistor, inductor, capacitor , Kirchhoff's
laws, Mesh analysis, Nodal analysis, Ideal sources –equivalent resistor, current
division, voltage division
UNIT II - MAGNETIC CIRCUITS (6 hours)
Introduction to magnetic circuits-Simple magnetic circuits-Faraday's laws,
induced emfs and inductances
UNIT III - AC CIRCUITS (6 hours)
Sinusoids, Generation of AC, Average and RMS values, Form and peak factors,
concept of phasor representation, J operator. Analysis of R-L, R-C, R-L-C
circuits. Introduction to three phase systems - types of connections, relationship
between line and phase values.
UNIT IV - ELECTRICAL MACHINES & MEASURING INSTRUMENTS (6 hours)
Working principle, construction and applications of DC machines and AC
machines (1 - phase transformers, single phase induction motors: split phase,
capacitor start and capacitor start & run motors). Basic principles and
classification of instruments -Moving coil and moving iron instruments.
46 Biotech-2013 SRM (E&T)
UNIT V - ELECTRICAL SAFETY, WIRING &INTRODUCTION TO POWER SYSTEM
(6 hours)
Safety measures in electrical system- types of wiring- wiring accessories-
staircase, fluorescent lamps & corridor wiring- Basic principles of earthing-Types
of earthing- Simple layout of generation, transmission & distribution of power.
TEXT BOOK
1. Dash.S.S, Subramani.C, Vijayakumar.K, “Basic Electrical Engineering”, First
edition, Vijay Nicole Imprints Pvt.Ltd,2013
REFERENCES
1. Smarajt Ghosh, “Fundamentals of Electrical & Electronics Engineering”,
Second edition, PHI Learning, 2007.
2. Metha V.K, Rohit Metha, “Basic Electrical Engineering”, Fifth edition,
S.Chand & Co, 2012.
3. Kothari. D. P and Nagrath.IJ, “Basic Electrical Engineering”, Second edition,
Tata McGraw - Hill, 2009
4. Bhattacharya.S.K, “Basic Electrical and Electronics Engineering”, First
edition, Pearson Education, 2011
EE1001 - BASIC ELECTRICAL ENGINEERING
Course Designed by
Department of Electrical and Electronics Engineering
1.
Student outcomes
a
b
c
d
e
f
g
h
i
j
k
x
x
2.
Mapping of instructional
objectives with student
outcome
1-3
1
3.
Category
General(G)
Basic
Sciences(B)
Engineering Sciences
and Technical
Arts(E)
Professional
Subjects(P)
--
--
x
--
4.
Approval
23rd Meeting of Academic Council, May 2013
47 Biotech-2013 SRM (E&T)
EC1001
BASIC ELECTRONICS ENGINEERING
L
T
P
C
Total Contact Hours – 30
2
0
0
2
Prerequisite
Nil
PURPOSE
This course provides comprehensive idea about working principle, operation and
characteristics of electronic devices, transducers, Digital Electronics and
Communication Systems.
INSTRUCTIONAL OBJECTIVES
At the end of the course students will be able to gain knowledge about the
1.
Fundamentals of electronic components, devices, transducers
2.
Principles of digital electronics
3.
Principles of various communication systems
UNIT I - ELECTRONIC COMPONENTS (4 hours)
Passive components – resistors, capacitors & inductors (properties, common
types, I-V relationship and uses).
UNIT II - SEMICONDUCTOR DEVICES (7 hours)
Semiconductor Devices - Overview of Semiconductors - basic principle,
operation and characteristics of PN diode, zener diode, BJT, JFET, optoelectronic
devices (LDR, photodiode, phototransistor, solar cell, optocouplers)
UNIT III - TRANSDUCERS (5 hours)
Transducers - Instrumentation – general aspects, classification of transducers,
basic requirements of transducers, passive transducers - strain gauge, thermistor,
Hall-Effect transducer, LVDT, and active transducers – piezoelectric and
thermocouple.
UNIT IV - DIGITAL ELECTRONICS (7 hours)
Number systems – binary codes - logic gates - Boolean algebra, laws & theorems
- simplification of Boolean expression - implementation of Boolean expressions
using logic gates - standard forms of Boolean expression.
UNIT V - COMMUNICATION SYSTEMS (7 hours)
Block diagram of a basic communication system – frequency spectrum - need for
modulation - methods of modulation - principles of AM, FM, pulse analog and
pulse digital modulation – AM / FM transmitters & receivers (block diagram
description only)
48 Biotech-2013 SRM (E&T)
TEXT BOOKS
1. Thyagarajan.T, SendurChelvi.K.P, Rangaswamy.T.R, “Engineering Basics:
Electrical, Electronics and Computer Engineering”, New Age International,
Third Edition, 2007.
2. Somanathan Nair.B, Deepa.S.R, “Basic Electronics”, I.K. International Pvt.
Ltd., 2009.
REFERENCES
1. Thomas L. Floyd, “Electronic Devices”, Pearson Education, 9th Edition, 2011.
2. Rajput.R.K, “Basic Electrical and Electronics Engineering”, Laxmi
Publications, First Edition, 2007.
EC1001 BASIC ELECTRONICS ENGINEERING
Course Designed by
Department of Electronics and Communication
Engineering
1.
Student outcome
a
b
c
d
e
f
g
h
i
j
k
X
2.
Mapping of instructional
objectives with student
outcome
1,2
,3
3.
Category
General
(G)
Basic
Sciences
(B)
Engineering
Sciences &
Technical Arts (E)
Professional
Subjects (P)
--
--
x
--
4.
Approval
23rd Meeting of Academic Council, May 2013
49 Biotech-2013 SRM (E&T)
ME1005
ENGINEERING GRAPHICS
L
T
P
C
Total Contact Hours - 75
0
1
4
3
Prerequisite
Nil
First Angle Projection is to be followed - Practice
with Computer Aided Drafting tools
PURPOSE
1.
To draw and interpret various projections of 1D, 2D and 3D objects.
2.
To prepare and interpret the drawings of buildings.
INSTRUCTIONAL OBJECTIVES
1.
To familiarize with the construction of geometrical figures
2.
To familiarize with the projection of 1D, 2D and 3D elements
3.
To familiarize with the sectioning of solids and development of
surfaces
4.
To familiarize with the Preparation and interpretation of building drawing
UNIT I - FUNDAMENTALS OF ENGINEERING GRAPHICS (2 hours)
Lettering – Two dimensional geometrical constructions – Conics – Representation
of three-dimensional objects – Principles of projections – Standard codes –
Projection of points.
UNIT II - PROJECTION OF LINES AND SOLIDS (4 hours)
Projection of straight lines – Projection of planes - Projection of solids – Auxiliary
projections.
UNIT III - SECTIONS AND DEVELOPMENTS (3 hours)
Sections of solids and development of surfaces.
UNIT IV - PICTORIAL PROJECTIONS (4 hours)
Conversion of Projections: Orthographic projection – Isometric projection of
regular solids and combination of solids.
UNIT V - BUILDING DRAWING (2 hours)
Plan, Elevation and section of single storied residential (or) office building with flat
RCC roof and brick masonry walls having not more than 3 rooms (planning /
designing is not expected in this course) with electrical wiring diagram.
PRACTICAL (60 hours)
50 Biotech-2013 SRM (E&T)
TEXT BOOKS
1. Venugopal.K and Prabhu Raja.V, “Engineering Graphics”, Eighth Edition
(Revised), New Age International Publishers, Chennai, 2007.
2. Natarajan.K.V, “A Text Book of Engineering Graphics”, 21st Edition,
Dhanalakshmi Publishers, Chennai, 2012.
3. Jeyapoovan.T, “Engineering Drawing and Graphics using AutoCAD”, Vikas
Publishing House Pvt. Ltd., New Delhi, 2010.
REFERENCES
1. Bethune.J.D, “Engineering Graphics with AutoCAD 2013”, PHI Learning
Private Limited, Delhi, 2013.
2. Bhatt.N.D, “Elementary Engineering Drawing (First Angle Projection)”,
Charotar Publishing Co., Anand, 1999.
3. Narayanan.K.L and Kannaiah.P, “Engineering Graphics”, Scitech
Publications, Chennai, 1999.
4. Shah.M.B and Rana.B.C, “Engineering Drawing”, Pearson Education
(Singapore) Pvt. Ltd., New Delhi, 2005.
ME1005 ENGINEERING GRAPHICS
Course Designed by
Department of Mechanical Engineering
1.
Student outcome
a
b
c
d
e
f
g
h
i
j
k
x
x
x
2.
Mapping of instructional
objectives with student
outcome
1-4
1-4
1-4
3.
Category
General(G)
Basic
sciences(B)
Engineering
sciences and
technical art (E)
Professional
subjects (P)
--
--
x
--
4.
Approval
23rd meeting of the Academic Council , May 2013
51 Biotech-2013 SRM (E&T)
ME1004
WORKSHOP PRACTICE
L
T
P
C
Total contact hours - 45
0
0
3
2
Prerequisite
Nil
PURPOSE
To provide the students with hands on experience on different trades of
engineering like fitting, carpentry, smithy, welding and sheet metal.
INSTRUCTIONAL OBJECTIVES
1.
To familiarize with the basics of tools and equipments used in fitting,
carpentry, sheet metal, welding and smithy
2.
To familiarize with the production of simple models in the above trades.
UNIT I - FITTING (9 hours)
Tools & Equipments – Practice in filing.
Making Vee Joints, Square, Dovetail joints and Key making - plumbing.
Mini project – Assembly of simple I.C. engines.
UNIT II - CARPENTRY (9 hours)
Tools and Equipments- Planning practice.
Making Half Lap, Dovetail, Mortise &Tenon joints.
Mini project - model of a single door window frame.
UNIT III - SHEET METAL (9 hours)
Tools and equipments– practice.
Making rectangular tray, hopper, scoop, etc.
Mini project - Fabrication of a small cabinet, dust bin, etc.
UNIT IV - WELDING (9 hours)
Tools and equipments -
Arc welding of butt joint, Lap joint, Tee fillet.
Demonstration of gas welding, TIG & MIG welding.
UNIT V - SMITHY (9 hours)
Tools and Equipments –
Making simple parts like hexagonal headed bolt, chisel.
52 Biotech-2013 SRM (E&T)
TEXT BOOK
1. Gopal.T.V, Kumar.T and Murali.G, “A first course on workshop practice –
Theory, Practice and Work Book”, Suma Publications, Chennai, 2005.
REFERENCES
1. Kannaiah.P and Narayanan.K.C, “Manual on Workshop Practice”, Scitech
Publications, Chennai, 1999.
2. Venkatachalapathy.V.S, “First year Engineering Workshop Practice”,
Ramalinga Publications, Madurai, 1999.
3. Laboratory Manual.
ME1004 - WORKSHOP PRACTICE
Course Designed by
Department of Mechanical Engineering
1.
Student outcome
a
B
c
d
e
f
g
h
i
j
k
×
×
×
2.
Mapping of instructional
objectives with student
outcome
1, 2
1, 2
1, 2
3.
Category
General (G)
Basic
Sciences(B)
Engineering
Sciences and
Technical Art(E)
Professional
Subjects
(P)
x
4.
Approval
23rd meeting of the Academic Council , May 2013
NC1001/
NS1001/
SP1001/
YG1001
NATIONAL CADET CORPS (NCC)/
NATIONAL SERVICE SCHEME (NSS)/
NATIONAL SPORTS ORGANIZATION (NSO) /
YOGA
L
T
P
C
Total Contact Hours – 15 (minimum, but may
vary depending on the course)
0
0
1
1
Prerequisite
Nil
PURPOSE
To imbibe in the minds of students the concepts and benefits of
NCC/NSS/NSO/YOGA and make them practice the same
INSTRUCTIONAL OBJECTIVES
1.
To enable the students to gain knowledge about NCC/NSS/NSO/YOGA
and put the same into practice
53 Biotech-2013 SRM (E&T)
NATIONAL CADET CORPS (NCC)
Any student enrolling as a member of National Cadet Core (NCC) will have to
attend sixteen parades out of twenty parades each of four periods over a span of
academic year.
Attending eight parades in first semester will qualify a student to earn the credits
specified in the curriculum. Grading shall be done based on punctuality, regularity
in attending the parades and the extent of active involvement.
NATIONAL SERVICE SCHEME (NSS)
A student enrolling as member of NSS will have to complete 60 hours of training /
social service to be eligible to earn the credits specified in the curriculum.
Grading shall be done by the faculty member handling the course based on
punctuality, regularity in attending the classes and the extent of active
involvement.
NATIONAL SPORTS ORGANIZATION (NSO)
Each student must select one of the following games/sports events and practice
for one hour per week. An attendance of 75% is compulsory to earn the credits
specified in the curriculum. Grading shall be done by the faculty member handling
the course based on punctuality, regularity in attending the classes and the extent
of active involvement.
List of games/sports:
Basket Ball, Football, Volley Ball, Ball Badminton, Cricket, Throw-ball, Track
events
Field events or any other game with the approval of faculty member.
YOGA
Benefits of Agnai Meditation -Meditation - Agnai, Asanas, Kiriyas, Bandas,
Muthras
Benefits of santhi Meditation - Meditation Santhi Physical Exercises (I & II)
Lecture & Practice - Kayakalpa Yoga Asanas, Kiriyas, Bandas, Muthras
Analysis of Thought - Meditation Santhi Physical Exercises III & IV
Benefits of Thuriyam - Meditation Thuriyam Kayakalpa Asanas, Kiriyas, Bandas,
Muthras
Attitude - Meditation Thuriyam Kayakalpa Asanas, Kiriyas, Bandas, Muthras
Importance of Arutkappy & Blessings - Meditation Thuriyam Kayakalpa Asanas,
Kiriyas, Bandas, Muthras
Benefits of Blessings - Meditation Santhi Kayakalpa Asanas, Kiriyas, Bandas,
Muthras
54 Biotech-2013 SRM (E&T)
Assessment
An attendance of 75% is compulsory to earn the credits specified in the
curriculum. Grading shall be done by the faculty member handling the course
based on punctuality, regularity in attending the classes and the extent of active
involvement.
REFERENCES
1. Yogiraj Vethathiri Maharishi, "Yoga for Modern Age", Vethathiri Publishers,
1989
2. Vethathiri Maharishi.T, "Simplified Physical Exercises", Vethathiri Publishers,
1987.
NC1001/ NS1001/ SP1001/
YG1001
NATIONAL CADET CORPS (NCC)/
NATIONAL SERVICE SCHEME (NSS)/
NATIONAL SPORTS ORGANIZATION (NSO)/YOGA
Course Designed by
NCC/ NSS/ NSO/YOGA UNITS
1.
Student outcome
a
b
C
d
e
f
g
h
i
j
k
2.
Mapping of instructional
objectives with student
outcome
X
X
3.
Category
General
(G)
Basic
Sciences
(B)
Engineering
Sciences and
Technical Arts (E)
Professional
Subjects(P)
X
4.
Approval
23rd Meeting of Academic Council, May 2013
55 Biotech-2013 SRM (E&T)
SEMESTER- III
LE1003
GERMAN LANGUAGE PHASE I
L
T
P
C
Total Contact Hours – 30
2
0
0
2
Prerequisite
Nil
PURPOSE
Germany offers infinite opportunities for students of engineering for higher
studies, research and employment in Germany. B.Tech Students are offered
German Language during their second year. Knowledge of the language will be
helpful for the students to adjust themselves when they go for higher studies.
INSTRUCTIONAL OBJECTIVES
1.
To introduce the language, phonetics and the special characters in German
language
2.
To introduce German culture & traditions to the students.
3.
By the end of Phase – I, the students will be able to introduce themselves
and initiate a conversation.
4.
We endeavor to develop the ability among the students to read and
understand small texts written in German
5.
To enable the students to elementary conversational skills.
UNIT I (6 hours)
Wichtige Sprachhandlungen: Phonetics – Sich begrüßen - Sich und andere
vorstellen formell / informell - Zahlen von 1 bis 1 Milliarde - verstehen & sprechen
Grammatik: regelmäßige Verben im Präsens - “sein” und haben im Präsens -
Personalpronomen im Nominativ
UNIT II (6 hours)
Wichtige Sprachhandlungen Telefon Nummern verstehen und sprechen
Uhrzeiten verstehen und sagen Verneinung “nicht und kein” (formell und informell)
Grammatik : Wortstellung – Aussagesatz – W-Frage und Satzfrage (Ja/Nein
Frage) Nomen buchstabieren und notieren bestimmter und unbestimmter Artikel
und Negativartikel im Nom. & Akkusativ
UNIT III (6 hours)
Wichtige Sprachhandlungen Tageszeiten verstehen und über Termine sprechen
-Verabredungen verstehen - Aufgaben im Haushalt verstehen Grammatik
Personalpronomen im Akkusativ und Dativ - W-Fragen “wie, wer, wohin,wo, was
usw.- Genitiv bei Personennamen - Modalverben im Präsens “können, müssen,
möchten”
56 Biotech-2013 SRM (E&T)
UNIT IV (6 hours)
Wichtige Sprachhandlungen Sich austauschen, was man kann, muss –
Bezeichnungen Lebensmittel – Mengenangaben verstehen – Preise verstehen und
Einkaufzettel schreiben
Grammatik Wortstellung in Sätzen mit Modalverben – Konnektor ”und” – “noch”-
kein-------mehr – “wie viel, wie viele, wie alt, wie lange” –Possessivartikel im
Nominativ.
UNIT V (6 hours)
Wichtige Sprachhandlungen Freizeitanzeigen verstehen – Hobbys und Sportarten
Anzeigen für Freizeitpartner schreiben bzw. darauf antworten – Vorlieben und
Abneigungen ausdrucken
Grammatik Verben mit Vokalwechsel im Präsens – Modalverben im Präsens
dürfen, wollen und mögen- “haben und sein” im Präteritum – regelmäßige Verben
im Perfekt – Konnektoren “denn, oder, aber
TEXT BOOK
1. Studio d A1. Deutsch als Fremdsprache with CD.(Kursbuch und Sprach
training).
REFERENCES
1. German for Dummies
2. Schulz Griesbach
LE1003 GERMAN LANGUAGE PHASE I
Course Designed by
Department of English and Foreign Languages
1.
Student outcome
a
b
c
d
e
f
g
h
i
j
k
x
2.
Mapping of instructional
objectives with student
outcome
1-5
3.
Category
General
(G)
Basic
Sciences (B)
Engineering
Sciences and
Technical Arts (E)
Professional
Subjects (P)
x
--
--
--
4.
Approval
23rd Meeting of Academic Council, May 2013
57 Biotech-2013 SRM (E&T)
LE1004
FRENCH LANGUAGE PHASE I
L
T
P
C
Total Contact Hours - 30
2
0
0
2
Prerequisite
Nil
PURPOSE
To enable the student learners acquire a basic knowledge of the French language
and concepts of general French for everyday interactions and technical French at
the beginner’s level and also to get to know the culture of France.
INSTRUCTIONAL OBJECTIVES
1.
To enable students improve their grammatical competence.
2.
To enhance their listening skills.
3
To assist students in reading and speaking the language.
4.
To enhance their lexical and technical competence.
5.
To help the students introduce themselves and focus on their
communication skills.
UNIT I (6 hours)
1. Grammar and Vocabulary: Usage of the French verb “se presenter”, a verb
of self- introduction and how to greet a person- “saluer”
2. Listening and Speaking – The authentic sounds of the letters of the French
alphabet and the accents that play a vital role in the pronunciation of the
words.
3. Writing – correct spellings of French scientific and technical vocabulary.
4. Reading -- Reading of the text and comprehension – answering questions.
UNIT II (6 hours)
1. Grammar and Vocabulary – Definite articles , “prepositions de lieu” subject
pron ouns
2. Listening and Speaking – pronunciation of words like Isabelle, presentez and
la liaison – vous etes, vous appelez and role play of introducing each other –
group activity
3. Writing – particulars in filling an enrollment / registration form
4. Reading Comprehension – reading a text of a famous scientist and answering
questions.
58 Biotech-2013 SRM (E&T)
UNIT III (6 hours)
1. Grammar and Vocabulary – verb of possession “avoir’ and 1st group verbs
“er”, possessive adjectives and pronouns of insistence- moi, lui..and
numbers from 0 to 20
2. Listening and Speaking –nasal sounds of the words like feminine, ceinture ,
parfum and how to ask simple questions on one’s name, age, nationality,
address mail id and telephone number.
3. Writing –conjugations of first group verbs and paragraph writing on self –
introduction and introducing a third person.
4. Reading Comprehension – reading a text that speaks of one’s profile and
answering questions
UNIT IV (6 hours)
1. Grammar and Vocabulary –negative sentences, numbers from 20 to 69, verb
“aimer”and seasons of the year and leisure activities.
2. Listening and Speaking – To express one’s likes and dislikes and to talk of
one’s pastime activities (sports activities), je fais du ping-pong and nasal
sounds of words – janvier, champagne
3. Writing- conjugations of the irregular verbs – faire and savoir and their usage.
Paragraph writing on one’s leisure activity- (passé temps favori).Conj
4. Reading- a text on seasons and leisure activities – answering questions.
UNIT V (6 hours)
1. Grammar and Vocabulary – les verbes de direction- to ask one’s way and to
give directions, verbes- pouvoir and vouloir and 2nd group verbs , a droite, la
premiere a gauche and vocabulary relating to accommodation.
2. Listening and Speaking – to read and understand the metro map and hence
to give one directions – dialogue between two people.
3. Writing –paragraph writing describing the accommodation using the different
prepositions like en face de, derriere- to locate .
4. Reading Comprehension -- a text / a dialogue between two on location and
directions- ou est la poste/ la pharmacie, la bibliotheque?......
TEXT BOOK
1. Tech French
REFERENCES
1. French for Dummies.
2. French made easy-Goyal publishers
3. Panorama
59 Biotech-2013 SRM (E&T)
LE1004 FRENCH LANGUAGE PHASE I
Course Designed by
Department of English and Foreign Languages
1.
Student outcome
a
b
c
d
e
f
g
h
i
j
k
x
2.
Mapping of instructional
objectives with student
outcome
1-5
3.
Category
General
(G)
Basic
Sciences (B)
Engineering
Sciences and
Technical Arts (E)
Professional
Subjects (P)
x
--
--
--
4.
Approval
23rd Meeting of Academic Council, May 2013
LE 1005
JAPANESE LANGUAGE PHASE I
L
T
P
C
Total Contact Hours- 30
2
0
0
2
Prerequisite
Nil
PURPOSE
To enable students achieve a basic exposure on Japan, Japanese language and
culture. To acquire basic conversational skill in the language.
INSTRUCTIONAL OBJECTIVES
1.
To help students learn the Japanese scripts viz. hiragana and a few basic
kanji.
2.
To make the students acquire basic conversational skill.
3.
To enable students to know about Japan and Japanese culture.
4.
To create an advantageous situation for the students to have better
opportunity for employability by companies who have association with
Japan.
UNIT I (8 hours)
1. Introduction to Japanese language. Hiragana Chart 1 - vowels and
consonants and related vocabulary.
2. Self introduction
3. Grammar – usage of particles wa, no, mo and ka and exercises
4. Numbers (1-100)
5. Kanji – introduction and basic kanjis – naka, ue, shita, kawa and yama
6. Greetings, seasons, days of the week and months of the year
7. Conversation – audio
8. Japan – Land and culture
60 Biotech-2013 SRM (E&T)
UNIT II (8 hours)
1. Hiragana Chart 1 (contd.) and related vocabulary
2. Grammar – usage of kore, sore, are, kono, sono, ano, arimasu and imasu.
Particles – ni (location) and ga. Donata and dare.
3. Numbers (up to 99,999)
4. Kanji – numbers (1-10, 100, 1000, 10,000 and yen)
5. Family relationships and colours.
6. Conversation – audio
7. Festivals of Japan
UNIT III (5 hours)
1. Hiragana Charts 2&3, double consonants, vowel elongation and related
vocabulary
2. Lesson 3
3. Grammar - particles ni (time), kara, made and ne. Koko, soko, asoko and
doko.
4. Time expressions (today, tomorrow, yesterday, day before, day after)
5. Kanji – person, man, woman, child, tree and book
6. Directions – north, south, east and west
UNIT IV (5 hours)
1. Grammar - directions,-kochira, sochira, achira and dochira. Associated
vocabulary (mae, ushiro, ue, shita, tonari, soba, etc.)
2. Conversation – audio
3. Japanese art and culture like ikebana, origami, etc.
UNIT V (4 hours)
1. Kanji – hidari, migi, kuchi
2. Japanese sports and martial arts
TEXT BOOK
1. First lessons in Japanese, ALC Japan
REFERENCES
1. Japanese for dummies. Wiley publishing co. Inc., USA.
2. Kana workbook, Japan foundation
61 Biotech-2013 SRM (E&T)
LE1005 JAPANESE LANGUAGE PHASE I
Course Designed by
Department of English and Foreign Languages
1.
Student outcome
a
b
c
d
e
f
G
h
i
j
k
X
2.
Mapping of instructional
objectives with student
outcome
1- 4
3.
Category
General
(G)
Basic
Sciences
(B)
Engineering
Sciences and
Technical Arts (E)
Professional
Subjects (P)
x
--
--
--
4.
Approval
23rd Meeting of Academic Council, May 2013
LE1006
KOREAN LANGUAGE PHASE I
L
T
P
C
Total Contact Hours-30
2
0
0
2
Prerequisite
Nil
PURPOSE
To enable students achieve a basic exposure on Korea, Korean language and
culture. To acquire basic conversational skill in the language.
INSTRUCTIONAL OBJECTIVES
1.
To help students learn the scripts.
2.
To make the students acquire basic conversational skill.
3
To enable students to know about Korean culture.
4.
To create an advantageous situation for the students to have better
opportunity for employability by companies who have association with
Korea.
UNIT I (6 hours)
Lesson 1 < Introduction to Korean Language >, Lesson2 < Consonants and
Vowels >, <Basic Conversation, Vocabularies and Listening >
UNIT II (10 hours)
Lesson 3 < Usage of “To be” >, Lesson 4 < Informal form of “to be” >,
Lesson 5 <Informal interrogative form of “to be” >, Lesson 6 < To be, to have,
to stay >, < Basic Conversation, Vocabularies and Listening >
62 Biotech-2013 SRM (E&T)
UNIT III (10 hours)
Lesson 7 < Interrogative practice and Negation >, < Basic Conversation,
Vocabularies and Listening >
UNIT IV (4 hours)
Lesson 8 < Korean Culture and Business Etiquette >, < Basic Conversation,
Vocabularies and Listening
TEXT BOOK
1. Korean through English 1 (Basic Korean Grammar and Conversation).
REFERENCES
1. Bharati Korean (Intermediate Korean Grammar).
2. Hand-outs.
3. Various visual mediums such Movie CD, Audio CD.
4. Collection of vocabularies for engineering field.
LE1006 KOREAN LANGUAGE PHASE I
Course Designed by
Department of English and Foreign Languages
1.
Student outcome
a
b
c
d
e
f
g
h
i
j
k
x
2.
Mapping of
instructional
objectives with
student outcome
1-4
3.
Category
General (G)
Basic
Sciences
(B)
Engineering Sciences and
Technical Arts (E)
Professional
Subjects (P)
x
--
--
--
4.
Approval
23rd Meeting of Academic Council, May 2013
LE1007
CHINESE LANGUAGE PHASE I
L
T
P
C
Total contact hours- 30
2
0
0
2
Prerequisite
Nil
PURPOSE
To enable students achieve a basic exposure on China, Chinese language and
culture. To acquire basic conversational skill in the language.
63 Biotech-2013 SRM (E&T)
INSTRUCTIONAL OBJECTIVES
1.
To help students learn the Chinese scripts.
2.
To make the students acquire basic conversational skill.
3
To enable students to know about China and Chinese culture.
4.
To create an advantageous situation for the students to have better
opportunity for employability by companies who have association with
china.
UNIT I
Introduction of Chinese Language
UNIT II
Phonetics and Notes on pronunciation
a) 21 Initials:
b p m f d t n l g k h j q x z c s zh ch sh r
b) 37 Finals:
a o e i u ü
ai ou ei ia ua üe
an ong en ian uai üan
ang eng iang uan ün
ao er iao uang
ie uei(ui)
in uen(un)
ing ueng
iong uo
iou(iu)
c) The combination of Initials and Finals - Pinyin
UNIT III
Introduction of Syllables and tones
a) syllable=initial+final+tone
b) There are four tones in Chinese: the high-and-level tone, the rising tone,
the falling-and-rising tone, and the falling tone. And the markers of the
different tones.
UNIT IV
a) Tones practice
b) The Strokes of Characters
1. Introduction of Chinese Characters
2. The eight basic strokes of characters
64 Biotech-2013 SRM (E&T)
UNIT V
1. Learn to read and write the Characters:
八(eight) 不(not) (horse) 米(rice) 木(wood ).
2. classes are organized according to several Mini-dialogues.
TEXT BOOK
1. A New Chinese Course 1- Beijing Language and Culture University Press.
REFERENCES
1. New Practical Chinese Reader Textbook (1) – Beijing Language and Culture
University Press.
2. 40 Lessons For Basic Chinese Course I – Shanghai Translation Press.
3. My Chinese Classroom - East China Normal University Press.
LE1007 CHINESE LANGUAGE PHASE I
Course Designed by
Department of English and Foreign Languages
1.
Student outcome
a
b
c
d
e
f
g
h
i
j
k
x
2.
Mapping of instructional
objectives with student
outcome
1 -
4
3.
Category
General
(G)
Basic
Sciences
(B)
Engineering
Sciences and
Technical Arts (E)
Professional
Subjects (P)
x
--
--
--
4.
Approval
23rd Meeting of Academic Council, May 2013
PD1003
APTITUDE-I
L
T
P
C
Total Contact Hours - 30
1
0
1
1
Prerequisite
Nil
PURPOSE
To enhance holistic development of students and improve their employability
skills.
INSTRUCTIONAL OBJECTIVES
1.
To improve aptitude, problem solving skills and reasoning ability of the
student.
2.
To collectively solve problems in teams & group.
65 Biotech-2013 SRM (E&T)
UNIT I - NUMBERS (6 hours)
Types and Properties of Numbers, LCM, GCD, Fractions and decimals, Surds
UNIT II - ARITHMETIC – I (6 hours)
Percentages, Profit & Loss, Simple Interest & Compound Interest, , Clocks &
calendars
UNIT III - ALGEBRA – I (6 hours)
Logarithms, Problems on ages
UNIT IV - MODERN MATHEMATICS - I (6 hours)
Permutations, Combinations, Probability
UNIT V - REASONING (6 hours)
Logical Reasoning, Analytical Reasoning
ASSESSMENT
1. Objective type – Paper based / Online – Time based test
REFERENCE
1. Agarwal.R.S, “Quantitative Aptitude for Competitive Examinations”, S.Chand
Limited 2011
2. Abhijit Guha, “Quantitative Aptitude for Competitive Examinations”, Tata
McGraw Hill, 3rd Edition,2011
3. Edgar Thrope, “Test Of Reasoning for Competitive Examinations”, Tata
McGraw Hill, 4th Edition, 2012
4. “Other material related to quantitative aptitude”
PD1003 – APTITUDE-I
Course Designed by
Career Development centre
1.
Student outcome
a
b
c
d
e
f
g
h
i
j
k
x
x
2.
Mapping of instructional
objectives with Student
outcome
1
2
3.
Category
General(G)
Basic
Sciences(B)
Engineering
Sciences and
Technical Arts(E)
Professional
Subjects(P)
x
4.
Approval
23rd Meeting of Academic Council, May 2013
66 Biotech-2013 SRM (E&T)
CH1051
CHEMICAL AND BIOCHEMICAL PROCESS
CALCULATION
L
T
P
C
Total No. of Contact Hours - 45
3
0
0
3
Prerequisite
Nil
PURPOSE
This course prepares the students to formulate and solve material and energy
balances on chemical and biochemical process systems.
INSTRUCTIONAL OBJECTIVES
To familiarize
1.
Basic principles of process calculations
2.
Material and Energy balance calculations
3.
Biochemical calculations
UNIT I - INTRODUCTION (9 hours)
Units and dimensions: the mole unit- mole fraction (or percent) and mass
fraction (or percent)- analyses of a mixture- concentrations- Basis of
calculations: predicting P-V-T properties of gases using the following equations
of state: ideal gas law- Van der Waals equation- Redlich-Kwong equation-
calculation of density.
UNIT II - CHEMICAL EQUATION AND MATERIAL BALANCES (9 hours)
Basics of chemical equation and stoichiometry: limiting reactant- excess
reactant- conversion- selectivity- yield. Basic concepts involved in material
balance calculations: material balance problems without chemical reactions:
membrane separation- mixing- drying- crystallization. Basic concepts of recycle-
bypass and purge streams.
UNIT III - COMBUSTION, PARTIAL SATURATION AND HUMIDITY (9 hours)
Introduction to combustion: flue gas- Orsat analysis- theoretical air- excess air-
determination of products of combustion of solid- liquid and gaseous fuels-
calculation of excess air. Humidity calculations: Saturated gas- partial saturation-
dew point- molal humidity- humidity- saturation molal humidity- saturation
humidity- percentage humidity- relative humidity. Material balances involved in the
following processes: dehydration- humidification- condensation
67 Biotech-2013 SRM (E&T)
UNIT IV - ENERGY BALANCES (9 hours)
Thermodynamics: Heat capacity of gases- empirical equations for heat
capacities- mean heat capacities of gases- Kopp's rule- latent heats- calculation
of enthalpy from thermophysical properties.-Thermochemistry: Standard heat of
reaction- heat of formation- law of Hess- standard heat of combustion- heats of
formation calculated from heats of combustion- calculation of the standard heat
of reaction from heats of formation or combustion- effect of temperature on heat
of reaction- enthalpy changes in reactions with different temperatures- calculation
of theoretical flame temperature.
UNIT V - MATERIAL & ELEMENTAL BALANCES FOR BIOCHEMICAL
PROCESSES (9 hours)
Growth of stoichiometry and elemental balances: Energy balance for continuous
ethanol fermentation- Mass balance for production of penicillin -Conservation of
mass principle: Acetic acid fermentation process -Xanthan gum production-
Stoichiometric coefficient for cell growth -Embden–Meyerhoff–Parnas pathway.
TEXT BOOKS
1. David M. Himmelblau, "Basic Principles and Calculations in Chemical
Engineering", 6th Edn., Prentice-Hall of India, New Delhi, 1998.
2. Hougen.O.A, Watsen.K.M and Ragartz. R.A, "Chemical Process Principles",
Part-I, John Wiley and Asia Publishing Co., 1976.
REFERENCES
1. Najafpour.G.D, “Biochemical Engineering and Biotechnology”, Elsevier,
2007.
2. Richard M. Felder, Ronald W. Rousseau, "Elementary Principles of Chemical
Processes", 3rd Edition by John Wiley & Sons, Inc. Singapore, 2000.
3. Bhatt.B.I and Vora.S.M, "Stoichiometry", 3rd Edn., Tata McGraw-Hill
Publishing Company, New Delhi, 1996.
CH1051 CHEMICAL AND BIOCHEMICAL PROCESS CALCULATION
Course Designed by
Department of Chemical Engineering
1.
Student outcomes
a
b
c
d
e
f
g
h
i
j
k
x
x
x
2.
Mapping of instructional
objectives with student
outcomes
1
3
2
3.
Category
General(G)
Basic
Sciences (B)
Engg. Sci. &
Tech. Arts (E)
Professional
Subjects (P)
x
4.
Approval
23rd Meeting of Academic Council, May 2013
68 Biotech-2013 SRM (E&T)
BT1006
LAB SAFETY AND ANALYTICAL TECHNIQUES
L
T
P
C
Total No. of Contact Hours – 30
2
0
0
2
Prerequisite
Nil
PURPOSE
The purpose of this course is to provide an understanding of fundamental
concepts and underlying principles in the instruments used in biotechnology. In
addition, the course is expected to develop the analytical skill to enable them to
interpret the experimental data.
INSTRUCTIONAL OBJECTIVES
1.
To provide the basic knowledge in the safety aspects and ethics
2.
To impart sufficient scientific understanding of the basic concepts in
instrumentation used in Biotechnology.
3.
To provide experience in various bioanalytical techniques.
4.
To apply the concepts in the interpretation of the data.
UNIT I - LABORATORY SAFETY (3 hours)
General rules - personal precautions – lab safety- good laboratory practices-lab
maintenance. Apparatus, Materials and reagents, test systems, test and
REFERENCE substances and standard operating procedures.
UNIT II - BIOSAFETY AND ETHICS IN THE LABORATORY (5 hours)
Biosafety levels-containment levels-risk assessment – guidelines - Regulations
specific o the biotechnology labs- Hazardous materials used in biotechnology-
disposal of chemical and hazardous chemicals- controlling the exposure of
hazardous chemicals-biological agents –handling and disposal-ethical issues.
UNIT III - BASIC INSTRUMENTS (5 hours)
Theory, instrumentation and applications of pH meter, colorimetry and
calorimetry.Electrophoresis- General principles- electrophoresis, PCR Machines-
handling and maintenance.
UNIT IV - MICROSCOPY & SPECTROSCOPY (9 hours)
Principle, working and applications of Microscopy- Dark-field, Phase contrast,
Fluorescence, Confocal, Polarization microscopy; Electron microscopy: TEM &
SEM.
69 Biotech-2013 SRM (E&T)
Spectroscopy techniques-Measurement of transmittance and absorbance – Beer
and Lambert’s law – spectrophotometer analysis – qualitative and quantitative
absorption measurements - General Principles, instrumentation, applications of
spectrometers – UV – visible, fluorescence, Infrared Spectroscopy- Atomic
absorption and Mass spectrometry.
UNIT V - CHROMATOGRAPHY (8 hours)
Chromatographic methods- General principles, instrumentation, applications,
classification of chromatographic techniques - Ion exchange, Gel filtration,
Affinity, Gas chromatography techniques and High Performance Liquid
Chromatography (HPLC).
TEXT BOOKS
1. Weinberg.S, “Good Laboratory Practice Regulation” Drugs and Pharm. Sci.
Series,Vol. 124, 2nd Ed., Maracel Dekker Inc., N.Y.
2. Willard.H.H, Merrit.L.L, Dean.J.A, Settle.P.A, “Instrumental Methods of
Analysis”, Van Nostrand, C B S Publishers &Distributors (1986).
3. Skoog.D.A, Heller.F.J, Nieman.T.A, “Principles of Instrumental Analysis”, WB
Saunders
REFERENCES
1. Sharma.P. P, “How to practice GLP” Vandana Publication.
2. Day.R.A and Underwood.A.L, “Quantitative Analysis”, 6th ed., Prentice Hall
of India Pvt. Ltd,(1993).
3. Hunson.J.W, “Pharmaceutical Analysis”, Modern Methods, part A & B,
Marcel Dekker.
4. Schirmer.R.E, “Modern Methods of Pharmaceutical Analysis”, Vols 1, 2.
Boca Raton F.L., CRC Press.
5. Mann.C.K, et al., “Instrumental Analysis “Harper & Row.
6. Eving.G.W, “Instrumental Methods of Chemical Analysis”, 5th ed., Mc-Graw
Hill Book Company (1985)
7. Silverstein, “Spectrometric identification of Organic Compounds”, 6th Ed.,
John Wiley& Sons, Inc., 1996.
8. Vogel.A.I, “Textbook of Quantitative Chemical Analysis”, 5th ed., Addison
Wesley Longman Singapore (1999).
70 Biotech-2013 SRM (E&T)
BT1006 LAB SAFETY AND ANALYTICAL TECHNIQUES
Course Designed by
Department of Biotechnology
1.
Student outcomes
a
b
c
d
e
f
g
h
i
j
k
x
x
x
x
x
2.
Mapping of
instructional
objectives with
student outcomes
1
2
3
4
3.
Category
General (G)
Basic
Sciences B)
Engg. Sci. &
Tech. Arts (E)
Professional
Subjects (P)
x
4.
Broad Area
Biotechnology
Bioprocess
Chemical
Engineering
x
--
--
--
5.
Approval
23rd Meeting of Academic Council, May 2013
BT1008
MICROBIOLOGY
L
T
P
C
Total No. of Contact Hours – 45
3
0
0
3
Prerequisite
Nil
PURPOSE
Introducing the fundamentals of microbiology through the study of the
characteristics of microorganisms, multiplication, growth in different media and
various metabolic pathways. Knowledge of these principles will enable students to
understand how they react under different conditions and how they cause
different diseases and their control
INSTRUCTIONAL OBJECTIVES
1.
To highlight the roles and characteristics of microorganisms
2.
To study in detail the growth of microorganisms and impact of environment
on their growth
3.
To evaluate explicitly, the metabolic pathways, role of microbes in public
health; insight into the physical and chemical control of microorganisms
UNIT I - INTRODUCTION TO MICROBIOLOGY (9 hours)
Basic of microbial existence: History of Microbiology, classification, and
nomenclature of microorganisms. Microscopy: Light and Electron microscopy.
Microscopic examination of microorganisms-morphology and fine structure of
bacteria
71 Biotech-2013 SRM (E&T)
UNIT II -MICROBIAL NUTRITION, GROWTH AND METABOLISM (9 hours)
Nutritional requirements of bacteria: Growth curve and Different methods to
quantitative bacterial growth.Aerobic and anaerobic bioenergetics- utilization of
energy. Biosynthesis of important molecules
UNIT III - MICROBIAL PHYSIOLOGY AND GENETICS (9 hours)
Fungi-Importance, characteristics, morphology, reproduction, physiology
cultivation,and Classification of fungi.Molds and repair association with other
organisms.Bacteriophages- General characteristics, Morphology and
structure.Classification and Nomenclature-Bacteriophages of E.coli.Replication-
Viruses of plants, animals,Structure, and Replication
UNIT IV - MICROBIAL INFECTIONS, TRANSMISSION, AND THEIR MODE OF
ACTION (9 hours)
Sources of infection: Portals of entry and Exit of microbes. Epidemiological
terminologies-Infectious diseases caused by Vibrio cholerae, Basidiomycetes,
and Sexually transmitted diseases- AIDS.Antimicrobial agents:Antibiotics-
Penicillins and Cephalosporins.Broad spectrum antibiotics: Antibiotics from
Prokaryotes. Antibacterial, Antifungal, and Antiviral agents- Mode of action.
Lantibiotics
UNIT V - APPLIED MICROBIOLOGY (9 hours)
Microbial metabolites:Microbial applications in agricultural, biotechnological,
pharmaceutical, and environmental applications. Physical, chemical, and
biological control of microorganisms.Host-microbe interactions such as plant-
microbe interaction& animal-microbe interaction
TEXT BOOKS
1. Pelczar et al., “Microbiology”,7th ed., Mc Graw Hill, 2011.
2. Madigan et al., “Brock Biology of microorganisms”, 12th ed., Prentice Hall,
2008.
3. Davis et al., “Microbiology”, 6th ed., Lippincott Williams and Wilkins, 2010.
4. Joklik et al., “Zinsser’s Microbiology”, 11th ed., Mc Graw-Hill Professional,
2010.
5. Stainer Ry et al., “General Microbiology”, 5th ed., Prentice Hall 1986.
REFERENCES
1. Prescott et al., “Microbiology”, 11th ed., Mc Graw Hill, 2011.
2. Brooks et al., “Medical Microbiology”, 26th ed., Lange Med. 2012.
72 Biotech-2013 SRM (E&T)
BT1008 MICROBIOLOGY
Course Designed by
Department of Biotechnology
1.
Student outcomes
a
b
c
d
e
F
g
h
i
j
K
x
x
x
2.
Mapping of
instructional objectives
with student outcomes
1
2
3
3.
Category
General (G)
Basic
Sciences(B)
Engg. Sci. &
Tech. Arts (E)
Professional
Subjects (P)
x
4.
Broad Area
Biotechnology
Bioprocess
Engineering
Chemical
Engineering
x
--
--
5.
Approval
23rd Meeting of Academic Council, May 2013
BT1010
IMMUNOLOGY
L
T
P
C
Total No. of Contact Hours - 45
3
0
0
3
Prerequisite
Nil
PURPOSE
Aimed at introducing the science of immunology and a detailed study of various
types of immune systems and their classification, structure, and mechanism of
immune activation.
INSTRUCTIONAL OBJECTIVES
To familiarize students with
1.
The immune system ,their structure and classification, genetic control of
antibody production, cellular immunology, mechanism of activation in
hypersensitive immune reaction
2.
The role of the immune molecules in infectious diseases, autoimmunity,
and cancer will be discussed
UNIT I - OVERVIEW OF THE IMMUNE SYSTEM (10 hours)
Introduction: overview of the immune system-Lymphatic system, Lymphoid
organs, Cells of the immune system and their functions-Immune system. Innate
and Acquired immunity: Cells and processes of Innate immunity—Cells and
organs of the Acquired immunity-Anatomical and Physiological barriers; Innate
immune response and their recognition structures; Pathogen elimination.
Comparative immunity.Plant Immune system. Immunogens and Antigens:
Requirements for immunogenicity; major classes of antigens; antigen recognition
by B and T lymphocytes
73 Biotech-2013 SRM (E&T)
UNIT II - ANTIBODY STRUCTURE AND FUNCTIONS, B CELL FUNCTION
(10 hours)
Immunoglobulins: Structure and function-- Monoclonal antibodies. B Cell
generation and differentiation: BCR--Antibody diversity: Genetic basis—T-
dependent activation of B cells-B-lymphocyte signal transduction.
Cytokines.Complement.
UNIT III - ANTIGEN – ANTIBODY INTERACTIONS (8 hours)
Antigen- antibody interaction: antibody affinity and activity- Isolation of lymphoid
cells from blood and lymphoid organs--precipitation reaction, agglutination
reaction --Radioimmunoassay, ELISA, Western Blot, Immunoprecipitation-
Immunofluoresence, flow cytometry. Cell culture and experimental animal
models. Analysis of gene expression
UNIT IV - T CELL MATURATION, ACTIVATION, & DIFFERENTIATION (9 hours)
MHC, antigen processing and presentations: T-cell receptors--T-cell maturation,
activation and differentiation-Cell mediated effector responses-Function of CD8+
T cells
UNIT V - IMMUNE SYSTEM IN HEALTH & DISEASE (8 hours)
Hypersensitive reactions--Immune responses to infectious diseases--Tumor
Immunology-Vaccines-Autoimmunity
TEXT BOOKS
1. Richard Coico, Geoffrey Sunshine, “Immunology: A short course” 6th Edition.
Wiley-Blackwell. 2009.
2. Kenneth Murphy, “Janeway’s Immunobiology,” 8th Edition, Garland, 2011.
REFERENCES
1. Sudha Gangal and Shubhangi Sontakke, “Textbook of basic and clinical
immunology,” Universities Press, 2013.
2. Thomas J. Kindt, Barbara A. Osborne, Richard A. Goldsby, “Kuby
Immunology,” Sixth edition, W. H. Freeman and Company, 2006.
74 Biotech-2013 SRM (E&T)
BT1010 IMMUNOLOGY
Course Designed by
Department of Biotechnology
1.
Student outcomes
a
b
c
d
e
f
g
h
i
j
k
x
x
2.
Mapping of instructional
objectives with student
outcomes
1
2
3.
Category
General (G)
Basic
Sciences(B)
Engg. Sci. &
Tech. Arts (E)
Professional
Subjects (P)
x
4.
Broad Area
Biotechnology
Bioprocess
Engineering
Chemical Engineering
x
--
--
5.
Approval
23rd Meeting of Academic Council, May 2013
BT1012
GENETICS AND CYTOGENETICS
L
T
P
C
Total No. of Contact Hours - 45
3
0
0
3
Prerequisite
Nil
PURPOSE
This course introduces the fundamentals of genetics. It discusses the pattern of
inheritance, chromosome structure, sex linked genes and inherited disorders,
construction of linkage maps and population analysis.
INSTRUCTIONAL OBJECTIVES
1.
To provide knowledge on the basic laws governing the pattern of inheritance
familiarize the students with the basic concepts and principles of nucleic
acids in prokaryotic and eukaryotic organisms
2.
To understand the concepts and experiments in preparation of linkage map.
3
To provide knowledge on inherited disorders and population genetics.
UNIT I - MENDELIAN GENETICS (10 hours)
Mendel’s experiments, Mendel’s laws, Gene interaction - Allelic and non-allelic –
epistasis, Multiple allelism – ABO and Rh factor inheritance, cytoplasmic
inheritance, sex determination, pedigree analysis – autosomal, sex linked,
cytoplasmic.
75 Biotech-2013 SRM (E&T)
UNIT II - LINKAGE AND RECOMBINATION MAPPING (9 hours)
Chromosome structure and organization, giant chromosomes, Linkage and
crossing over, cytological basis of crossing over – Sterns experiment, Mapping –
two and three factor cross, preparation of linkage map, somatic cell hybridization,
CGH.
UNIT III - MUTATION AND HUMAN CYTOGENETICS (10 hours)
Changes in chromosome and number, Non-disjunction, Aneuploids in humans –
Autosomal - Downs, Patau and Edwards syndrome; Allosomes - Klinefelter and
Turner syndrome, mosaics, position effect, chromosome preparation –
leucocytes, bone marrow, amniotic fluid, chorionic villi, Banding, karyotype
preparation and analysis, FISH, Prenatal diagnosis.
UNIT IV - RECOMBINATION AND MAPPINGIN BACTERIA (8 hours)
Mechanisms of recombination, Mapping – transformation, Transduction mapping
– generalized and specialized transduction, conjugation – interrupted mating
analysis, Fine structure in merozygotes.
UNIT V - POPULATION GENETICS (8 hours)
Hardy Weinberg equilibrium, calculating allelic frequency, Application of Hardy
Weinberg equilibrium, Random genetic drift, founders effect, genetic equilibrium.
TEXT BOOK
1. Gardner, Simmons, Sunstad, “Principles of Genetics,” 8th edition – John
Wiley and Sons, Inc., 2003.
REFERENCE
1. Monroe W. Strickberger, “Genetics,” 3rd edition – Phi Learning, 2008.
BT1012 GENETICS AND CYTOGENETICS
Course Designed by
Department of Biotechnology
1.
Student outcomes
a
b
c
d
e
f
g
h
I
j
k
x
x
2.
Mapping of instructional
objectives with student
outcomes
1
2
3.
Category
General (G)
Basic
Sciences (B)
Engg. Sci. &
Tech. Arts (E)
Professional
Subjects (P)
x
4.
Broad Area
Biotechnology
Bioprocess
Engineering
Chemical Engineering
x
--
--
5.
Approval
23rd Meeting of Academic Council, May 2013
76 Biotech-2013 SRM (E&T)
BT1007
LAB SAFETY AND ANALYTICAL TECHNIQUES LAB
L
T
P
C
Total No. of Contact Hours – 30
0
0
2
1
Prerequisite
BT1006
PURPOSE
The PURPOSE of this course is to give a comprehensive understanding of the
various techniques used in the analysis of compounds and drugs by different
branches of biotechnology. The student will gain thorough information on the
principles of the techniques.
INSTRUCTIONAL OBJECTIVES
1.
To impart knowledge about the working of the instruments
2.
To teach the application of techniques in biotechnology and related fields
3.
To apply the concepts in the interpretation of the data.
LISTOF EXPERIMENTS
1. Studies on pH titration curves of amino acids/ acetic acid and determination
of pKavalues.
2. Separation of serum protein by horizontal submerged gel electrophoresis.
3. Determination of concentration of dye by Colorimetry
4. Study of UV absorption spectra of macromolecules (protein, nucleic acid,
bacterial pigments).
5. Determination of functional groups of protein by FT-IR
6. Separation of bacterial lipids/amino acids/sugars/organic acids by TLC or
Paper Chromatography.
7. HPLC –Demonstration
8. FPLC-Demonstration
9. LC-MS Demonstration
10. Principles of Microscopy-SEM and TEM-Demonstration
11. Atomic Adsorption Spectroscopy – Demonstration
REFERENCE
1. Lab Manual
77 Biotech-2013 SRM (E&T)
BT1007 LAB SAFETY AND ANALYTICAL TECHNIQUES LAB
Course Designed by
Department of Biotechnology
1.
Student outcomes
a
b
c
d
e
f
g
h
i
j
k
x
x
x
2.
Mapping of instructional
objectives with student
outcomes
1
2
3
3.
Category
General(G)
Basic
Sciences(B)
Engg. Sci. &
Tech Arts (E)
Professional
Subjects (P)
x
4.
Broad Area
Biotechnology
Bioprocess
Engineering
Chemical Engineering
x
--
--
5.
Approval
23rd Meeting of Academic Council, May 2013
BT1009
MICROBIOLOGY LABORATORY
L
T
P
C
Total No. of Contact Hours – 60
0
0
4
2
Prerequisite
BT1008
PURPOSE
Provides an opportunity to experimentally verify the theoretical concepts studied.
It also helps in understanding the theoretical principles in a more explicit and
concentrated manner.
INSTRUCTIONAL OBJECTIVES
1.
To enable the students to understand the basic concepts involved in the
isolation, identification and characterization of different kinds of
microorganisms
2.
To impart the proper handling experience of microorganisms
3.
To provide the complete practical experience on microbiological methods
and getting useful microbial products.
LIST OF EXPERIMENTS
1. Aseptic technique and Media preparation
2. Culturing of microorganisms– in broth and in plates (pour plates, streak
plates, isolation, and preservation of bacterial cultures)
3. Growth Kinetics (Bacterial Growth Curve)
4. Isolation, enumeration and purification of microbes from a given sample
78 Biotech-2013 SRM (E&T)
5. Staining Techniques (Simple, Gram staining, and spore staining)
6. Motility test by Hanging drop method
7. Biochemical Characterization of Bacteria
a. Oxidation/Fermentation Test
b. Catalase, Oxidase, and Urease Tests
c. IMViC test
d. Hydrogen Sulfide Test and Nitrate Reduction Test
e. Casein and Starch Hydrolysis
8. Identification of bacteria using 16s-rRNA method
9. Kirby-Bauer assay
10. Screening and characterization of bioactive molecules from bacteria
REFERENCES
1. Russell Bey, “Microbiology Laboratory Manual”, Thomson Learning, 2000.
2. Tabo.N,“Laboratory Manual in Microbiology”, Rex Bookstore, Inc 2004.
BT1009 MICROBIOLOGY LABORATORY
Course Designed by
Department of Biotechnology
1.
Student outcomes
a
b
c
d
e
f
g
h
i
J
k
x
x
x
x
2.
Mapping of instructional
objective with student
outcomes
1
2
3
1
3.
Category
General (G)
Basic
Sciences(B)
Engg. Sci. &
Tech. Arts (E)
Professional
Subjects (P)
x
4.
Broad Area
Biotechnology
Bioprocess
Engineering
Chemical Engineering
x
--
--
5.
Approval
23rd Meeting of Academic Council, May 2013
BT1011
IMMUNOLOGY LABORATORY
L
T
P
C
Total No. of Contact Hours - 60
0
0
4
2
Prerequisite
BT1010
PURPOSE
A laboratory course with an opportunity to experimentally verify the theoretical
concepts already studied.
79 Biotech-2013 SRM (E&T)
INSTRUCTIONAL OBJECTIVES
1.
To enable the students to understand the theoretical concepts in Immunology.
2.
To provide students with some experience in methods used in immunology,
particularly the use of specific antibody in biomolecular applications.
3.
To understand various methods and their applications, and interpretation of
results
LIST OF EXPERIMENTS
1. Blood grouping
2. Leukocyte counting – Total leukocyte and differential leukocyte
3. Isolation of peripheral blood mononuclear cells (PBMC)
4. Antigen-antibody reaction -Haemagglutination,
5. Precipitation reaction-Widal and VDRL
6. Immunodiffusion – Single Radial Immuno Diffusion (SRID)
7. Immunodiffusion – Double Immuno Diffusion (DID)
8. Immunoelectrophoresis – Rocket Immunoelectrophoresis
9. Immunoelectrophoresis – Counter Current Immunoelectrophoresis
10. ELISA
11. Immunoprecipitation
12. Western blotting
13. Flow cytometry
REFERENCES
1. Immunology Laboratory manual.
2. Arti Nigam,Archana Ayyagari, “Lab Manual in Biochemistry, Immunology and
Biotechnology”, Mc Graw Hill Education, India, 2007.
BT1011 IMMUNOLOGY LABORATORY
Course Designed by
Department of Biotechnology
1.
Student outcomes
a
b
c
d
e
f
g
h
i
j
k
x
x
x
2.
Mapping of instructional
objective with student
outcomes
1
3
2
3.
Category
General
(G)
Basic
Sciences (B)
Engg. Sci. &
Tech. Arts (E)
Professional
Subjects (P)
x
4.
Broad area
Biotechnology
Bioprocess
Engineering
Chemical
Engineering
x
--
--
5.
Approval
23rd Meeting of Academic Council, May 2013
80 Biotech-2013 SRM (E&T)
BT1013
CELL BIOLOGY LABORATORY
L
T
P
C
Total No. of Contact Hours - 60
0
0
4
2
Prerequisite
BT1003
PURPOSE
Provides an opportunity to experimentally verify the theoretical concepts. It also
helps in understanding the theoretical principles in a more explicit and
concentrated manner.
INSTRUCTIONAL OBJECTIVES
1.
To impart practical knowledge about cell growth and cell differentiation
2.
To develop skill in isolation and identification of cell organelles using
advanced tools
3.
To learn about cancer cell culture and to check the cell toxicity of different
products
4.
To provide practical skill in handling molecular techniques like PCR and
western blotting
LIST OF EXPERIMENTS
1. Cell cycle – Mitosis and Meiosis
2. Cell organelles – Isolation of mitochondria, chloroplast and lysosome
3. Cell morphology – Staining of hepatocytes, adipocytes and osteocytes
4. Cell toxicity – Quantification of mitochondrial dehydrogenase and plasma
membrane lactate dehydrogenase
5. Cancer cells – Culture of tumor cells and transformed cell lines
6. Mutation – Isolation of genetic variants
7. Mendelian principles – Genetic crosses in fruit fly
8. Chromosome preparation - Karyotyping
9. Nucleus – Isolation of nuclear proteins by western blotting
10. Heterochromatin – Polytene and lampbrush chromosome
REFERENCES
1. John Davey, Mike Lord, “Essential Cell Biology: A Practical Approach”,
Oxford University Press, 2003.
2. Robin Harris, John Graham, David Rickwood, “Cell Biology Protocols”, John
Wiley & Sons, 2006.
3. Thomas Robert Mertens, Robert L Hammersmith, “Genetics Laboratory
Investigations”, Benjamin Cummings, 2006.
81 Biotech-2013 SRM (E&T)
Course Designed by
Department of Biotechnology
1.
Student outcome
a
b
c
d
e
f
g
h
i
j
k
x
x
2.
Mapping of instructional
objectives with student
outcome
1
1
3.
Category
General
(G)
Basic
Sciences(B)
Engineering Sciences
and Technical Arts (E)
Professional
Subjects(P)
x
4.
Broad Area
Biotechnology
Bioprocess
Engineering
Chemical
Engineering
x
-
-
5.
Approval
23rd Meeting of Academic Council, May 2013
82 Biotech-2013 SRM (E&T)
SEMESTER – IV
LE1008
GERMAN LANGUAGE PHASE II
L
T
P
C
Total Contact Hours- 30
2
0
0
2
Prerequisite
LE1003-German Language Phase I
PURPOSE
Familiarity in German language will be helpful for the students in preparing their
resumes in German. Proficiency in the language will be an added asset for the
students to have an edge in the present day highly competitive and global job
market.
INSTRUCTIONAL OBJECTIVES
1.
To enable the students to speak and understand about most of the activities
in the day to day life.
2.
The students will be able to narrate their experiences in Past Tense.
3.
The students will be able to understand and communicate even with German
Nationals.
4.
By the end of Phase – II the students will have a reasonable level of
conversational skills.
UNIT I (6 hours)
Wichtige Sprachhandlungen: Zimmersuche, Möbel
Grammatik: Verben mit trennbaren Vorsilben im Präsens und Perfekt. Verben mit
trennbaren Vorsilben und Modalverben imPräsens. Verben mit untrennbaren
Vorsilben im Perfekt. Unregelmäßige und gemischte Verben im Perfekt.
UNIT II (6 hours)
Wichtige Sprachhandlungen: Kleidung ,Farben , Materialien.
Grammatik : formelle Imperativsätze mit “Sie” informelle Imperativsätze
Vorschläge mit “wir” – “sollen/wollenwir”—Soll ich? Modalpartikeln “doch” “mal”
“doch mal.
UNIT III (6 hours)
Wichtige Sprachhandlungen : Sehenswürdigkeite (Prater, Brandenburger
Tör,Kolossium, Eifeltürm)
Grammatik : Ortsangaben mit Akk. und Dativ “alle”,”man” Indefinitepronomen
“etwas”, “nichts”,
83 Biotech-2013 SRM (E&T)
UNIT IV (6 hours)
Wichtige Sprachhandlungen : Wegbeschreibung/ Einladung interkulturelle
Erfahrung.
Grammatik : Verwendung von Präsens für zukünftigen Zeitpunkt.
UNIT V (6 hours)
Wichtige Sprachhandlungen: Essen und Trinken im Restaurant ,
Partyvorbereitung und Feier
Grammatik: Nomen aus Adjektiven nach “etwas”und “nichts” Nomen aus dem
Infinitiv von Verben, zusammegesetzte Nomen und ihre Artikel. Adjektive im Nom.
und Akk. nach unbestimmten Artikel, Negativartikel und Possessivartikel.
TEXT BOOK
Studio d A1. Deutsch als Fremdsprache with CD.(Kursbuch und Sprachtraining).
REFERENCES
1. German for Dummies
2. Schulz Griesbach
LE01008 GERMAN LANGUAGE PHASE II
Course Designed by
Department of English and Foreign Languages
1.
Student outcome
a
b
c
d
e
f
g
h
i
j
k
x
2.
Mapping of instructional
objectives with student
outcome
1-4
3.
Category
General (G)
Basic
Sciences (B)
Engineering
Sciences and
Technical Arts (E)
Professional
Subjects (P)
x
--
--
--
4.
Approval
23rd Meeting of Academic Council, May 2013
84 Biotech-2013 SRM (E&T)
LE1009
FRENCH LANGUAGE PHASE II
L
T
P
C
Total Contact Hours- 30
2
0
0
2
Prerequisite
LE1004- French Language Phase I
PURPOSE
To enable the students communicate effectively with any French speaker and
have a competitive edge in the international market.
INSTRUCTIONAL OBJECTIVES
1.
To enable students access information on the internet
2.
To receive and send e mails
3.
To assist students in gaining a certain level of proficiency to enable them to
give the level 1 exam conducted by Alliance Française de Madras.
4.
To enhance their lexical and technical competence.
UNIT I (6 hours)
1. Grammar and Vocabulary: The second group verbs: Finir, rougir, grossir,
grandir . “Les preposition de temps”: à, en, le, de 7h à 8h, jusqu’ à, vers.
2. Listening and Speaking – the semi- vowels: Voilà, pollutant. Writing –the
days of the week. Months, technical subjects, time, “les spécialités
scientifiques et l’ année universitaire, paragraph writing about time table.
3. Reading -- Reading of the text and comprehension – answering questions
UNIT II (6 hours)
Grammar and Vocabulary – The adjectives, the nationality, feminine & masculine
noun forms “les métiers scientifiques”.
Listening and Speaking – Vowels: soirée, année, près de, très.
Writing – Countries name, nationality, “les métiers scientifiques”, numbers from:
69 to infitive and some measures of unit.
Reading Comprehension – reading a text.
UNIT III (6 hours)
Grammar and Vocabulary – near future, The demonstrative adjectives, Express
the aim by using the verb, Listening and Speaking –“La liaison interdite – en
haut”. Writing – some scientific terms, French expressions to accept an invitation.
Sentence framing. Reading Comprehension – reading a text.
85 Biotech-2013 SRM (E&T)
UNIT IV (6 hours)
Grammar and Vocabulary –the verbs: manger, boire , the partitive articles
Listening and Speaking – “le ‘e’ caduc Writing- the food, the ingredients, fruits,
vegetables, expression of quantity, paragraph writing about food habits. Reading –
reading a text.
UNIT V (6 hours)
Grammar and Vocabulary – “ les prepositions de lieu”: au à la, à l’, chez, the
reflexives verbs, verbs to nouns. Listening and Speaking – “le ‘e’ sans accents ne
se prononce pas. C’est un “e” caduc. Ex: quatre, octobre. “ les sons (s) et (z)-
salut , besoin. Writing –paragraph writing about one’s everyday life, French
culture. Reading Comprehension -- reading a text or a song.
TEXT BOOK
1. Tech French
REFERENCES
1. French for Dummies
2. French made easy: Goyal publishers
3. Panorama
LE1009 FRENCH LANGUAGE PHASE II
Course Designed by
Department of English and Foreign Languages
1.
Student outcome
a
b
c
d
e
f
g
h
i
j
k
x
2.
Mapping of instructional
objectives with student
outcome
1-4
3.
Category
General (G)
Basic
Sciences (B)
Engineering
Sciences and
Technical Arts (E)
Professional
Subjects (P)
x
--
--
--
4.
Approval
23rd Meeting of Academic Council, May 2013
86 Biotech-2013 SRM (E&T)
LE 1010
JAPANESE LANGUAGE PHASE II
L
T
P
C
Total Contact Hours- 30
2
0
0
2
Prerequisite
LE1005- Japanese Language Phase I
PURPOSE
To enable students to learn a little advanced grammar in order to improve their
conversational ability in Japanese.
INSTRUCTIONAL OBJECTIVES
1.
To help students learn Katakana script (used to write foreign words)
2.
To improve their conversational skill.
3
To enable students to know about Japan and Japanese culture.
4.
To improve their employability by companies who are associated with
Japan.
UNIT I (8 hours)
Introduction to Verbs; Ikimasu, okimasu, nemasu, tabemasu etc.
Grammar – usage of particles de, o, to, ga(but) and exercises
Common daily expressions and profession.
Katakana script and related vocabulary.
Religious beliefs, Japanese housing and living style.
Conversation – audio
UNIT II (8 hours)
Grammar :Verbs –Past tense, negative - ~mashita, ~masen deshita..
i-ending and na-ending adjectives - introduction
Food and transport (vocabulary)
Japanese food, transport and Japanese tea ceremony.
Kanji Seven elements of nature (Days of the week)
Conversation – audio
UNIT III (6 hours)
Grammar - ~masen ka, mashou
Adjectives (present/past – affirmative and negative)
Conversation – audio
UNIT IV (4 hours)
Grammar – ~te form
Kanji – 4 directions
Parts of the body
Japanese political system and economy
Conversation – audio
87 Biotech-2013 SRM (E&T)
UNIT V (4 hours)
Stationery, fruits and vegetables
Counters – general, people, floor and pairs
TEXT BOOK
1. First lessons in Japanese, ALC Japan
REFERENCES
1. Japanese for dummies. Wiley publishing co. Inc., USA.
2. Kana workbook, Japan foundation
LE1010 JAPANESE LANGUAGE PHASE II
Course Designed by
Department of English and Foreign Languages
1.
Student outcome
a
b
c
d
e
f
g
h
i
j
k
x
2.
Mapping of instructional
objectives with student
outcome
1-4
3.
Category
General
(G)
Basic
Sciences
(B)
Engineering
Sciences and
Technical Arts (E)
Professional
Subjects (P)
x
--
--
--
4.
Approval
23rd Meeting of Academic Council, May 2013
LE1011
KOREAN LANGUAGE PHASE II
L
T
P
C
Total Contact Hours-30
2
0
0
2
Prerequisite
LE1006-Korean Language Phase I
PURPOSE
To enable students achieve a basic exposure on Korea, Korean language and
culture. To acquire basic conversational skill in the language.
INSTRUCTIONAL OBJECTIVES
1.
To help students learn the scripts.
2.
To make the students acquire basic conversational skill.
3
To enable students to know about Korean culture.
4.
To create an advantageous situation for the students to have better
opportunity for employability by companies who have association with
Korea.
88 Biotech-2013 SRM (E&T)
UNIT I (9 hours)
Lesson 1 <Review of Vowels and Consonants>, Lesson2 < Various Usages of
“To be”>, Lesson3 < Informal form of “to be”> <Basic Conversation,
Vocabularies and Listening>
UNIT II (9 hours)
Lesson 4 < Informal interrogative form of “to be”>, Lesson 5 < To be, to have,
to stay>, Lesson 5 < Advanced Interrogative practice>, Lesson 6 < Types of
Negation>, <Basic Conversation, Vocabularies and Listening>
UNIT III (9 hours)
Lesson 7 < Honorific forms of noun and verb2>, Lesson8 < Formal
Declarative2>, Lesson 9 < Korean Business Etiquette>, <Basic Conversation,
Vocabularies and Listening>
UNIT IV (3 hours)
Lesson 10 <Field Korean as an Engineer1>, <Field Korean as an Engineer2>
<Basic Conversation, Vocabularies and Listening>
TEXT BOOK
1. Korean through English 2 (Basic Korean Grammar and Conversation)
REFERENCES
1. Bharati Korean (Intermediate Korean Grammar)
2. Hand-outs
3. Various visual media such Movie CD, Audio CD, and music
4. Collection of vocabularies for engineering field.
LE1011 KOREAN LANGUAGE PHASE II
Course Designed by
Department of English and Foreign Languages
1.
Student outcome
a
b
c
d
e
f
g
h
i
j
k
x
2.
Mapping of instructional
objectives with student
outcome
1-4
3.
Category
General
(G)
Basic
Sciences(B)
Engineering Sciences
and Technical Arts (E)
Professional
Subjects (P)
x
--
--
--
4.
Approval
23rd Meeting of Academic Council, May 2013
89 Biotech-2013 SRM (E&T)
LE1012
CHINESE LANGUAGE PHASE II
L
T
P
C
Total Contact Hours-30
2
0
0
2
Prerequisite
LE1007-Chinese Language Phase I
PURPOSE
To enable students achieve a basic exposure on China, Chinese language and
culture. To acquire basic conversational skill in the language.
INSTRUCTIONAL OBJECTIVES
1.
To help students learn the Chinese scripts.
2.
To make the students acquire basic conversational skill.
3
To enable students to know about China and Chinese culture.
4.
To create an advantageous situation for the students to have better
opportunity for employability by companies who have association with
china.
UNIT I
1. Greetings
Questions and answers about names
Introducing oneself
Receiving a guest
Making corrections
New words: （you） 好（good，well）
工作（work，job）人 （personnel，staff member） （May I
ask…） （expensive ，valuable） 姓（one’s family name is ）
2. Questions and answers about the number of people in a family
Expressing affirmation/negation
Questions and answers about the identity of a person same or not.
New words: 家（family，home） 有（have） 几（several）
爸爸 (father）(mother) 哥哥 (elderly brother）
UNIT II
A. About places
B. About numbers
C. if one knows a certain person
D. Expressing apology
E. Expressing affirmation/negation
F. Expressing thanks.
90 Biotech-2013 SRM (E&T)
New Words:
客人（guest,visitor） （here）中文（Chinese） （right, correct）
生（student） 多（many, a lot）
Grammar:Sentences with a verbal predicate
UNIT III
Introducing people to each other
A. Exchanging amenities
B. Making/Negating conjectures
C. Questions and answers about nationality
Grammar: Sentences with an adjectival predicate
UNIT IV
A) About places to go
Indicating where to go and what to do
Referring to hearsay.
Saying good-bye
B) Making a request
Questions and answers about postcodes and telephone numbers
Reading dates postcodes and telephone numbers
Counting Renmibi
Grammar:Sentences with a subject-verb construction as its predicate
Sentences with a nominal predicate
UNIT V
A. Asking and answering if someone is free at a particular time
B. Making proposals
C. Questions about answers about time
D. Making an appointment
E. Telling the time
F. Making estimations
TEXT BOOK
1. New Chinese Course 1- Beijing Language and Culture University Press
REFERENCES
1. New Practical Chinese Reader Textbook (1) – Beijing Language and Culture
University Press
2. 40 Lessons For Basic Chinese Course I – Shanghai Translation Press
3. My Chinese Classroom - East China Normal University Press
91 Biotech-2013 SRM (E&T)
LE1012 CHINESE LANGUAGE PHASE II
Course Designed by
Department of English and Foreign Languages
1.
Student outcome
a
b
c
d
e
f
g
h
i
j
k
x
2.
Mapping of instructional
objectives with student
outcome
1 - 4
3.
Category
General
(G)
Basic
Sciences (B)
Engineering
Sciences and
Technical Arts (E)
Professional
Subjects (P)
x
--
--
--
4.
Approval
23rd Meeting of Academic Council, May 2013
PD1004
APTITUDE-II
L
T
P
C
Total Contact Hours - 30
1
0
1
1
Prerequisite
Nil
PURPOSE
To enhance holistic development of students and improve their employability
skills.
INSTRUCTIONAL OBJECTIVES
1.
To improve verbal aptitude, vocabulary enhancement and reasoning ability
of the student.
UNIT I (6 hours)
Critical Reasoning – Essay Writing
UNIT II (6 hours)
Synonyms – Antonyms - Odd Word - Idioms & Phrases
UNIT III (6 hours)
Word Analogy - Sentence Completion
UNIT IV (6 hours)
Spotting Errors - Error Correction - Sentence Correction
92 Biotech-2013 SRM (E&T)
UNIT V (6 hours)
Sentence Anagram - Paragraph Anagram - Reading Comprehension
ASSESSMENT
1. Objective type – Paper based /Online – Time based test
TEXT BOOK
1. Personality Development -Verbal Work Book, Career Development Centre,
SRM Publications
REFERENCES
1. Green Sharon Weiner.M.A & Wolf Ira K.Barron’s New GRE,19th Edition.
Barron’s Educational Series, Inc, 2011.
2. Lewis Norman, Word Power Made Easy, Published by W.R.Goyal Pub, 2011.
3. Thorpe Edgar and Thorpe Showich, Objective English. Pearson Education
2012.
4. Murphy Raymond, Intermediate English Grammar, (Second Edition),
Cambridge University Press, 2012.
PD1004 - APTITUDE-II
Course Designed by
Career Development Centre
1.
Student outcome
a
b
c
d
e
f
g
h
i
j
k
x
2.
Mapping of instructional
objectives with student
outcome
1
3.
Category
General(G)
Basic
Sciences(B)
Engineering
Sciences and
Technical Arts(E)
Professional
Subjects(P)
x
4.
Approval
23rd Meeting of Academic Council, May 2013
MA1034
BIOSTATISTICS
L
T
P
C
Total No. of Contact Hours =60 Hours
4
0
0
4
Prerequisite
Nil
PURPOSE
To develop an understanding of the methods of probability andstatistics which are
used to model engineering problems.
93 Biotech-2013 SRM (E&T)
INSTRUCTIONAL OBJECTIVES
1.
To gain knowledge in measures of central tendency and dispersion.
2.
To appropriately choose, define and/or derive probability distributions such as
the Binomial, Poisson and normal distribution to solve engineering problems.
3.
To learn how to formulate and test the hypotheses about means, proportions
and standard deviation to draw conclusions based on the results of statistical
tests in large sample.
4.
To learn how to formulate and test the hypotheses about means, variances for
small samples using t and F test for small sample and have knowledge on
ANOVA.
5.
To understand the fundamentals of quality control and the methods used to
control systems and processes.
UNIT I - INTRODUCTION TO BIO-STATISTICS (NUMERICAL PROBLEMS ONLY)
(12 hours)
Handling univariate and bivariate data - Measures of central tendency - Measures
of dispersion -Skewness & Kurtosis - Correlation and Regression.
UNIT II - PROBABILITY & THEORETICAL DISTRIBUTIONS (12 hours)
Probability concepts - conditional probability - Baye's theorem - one - dimensional
random variables - expectation, variance, moments. Theoretical distributions :
Binomial, Poisson, Normal (Problems only).
UNIT III - TESTING OF HYPOTHESIS (12 hours)
Introduction - Large sample tests based on normal distribution - Test for single
mean, difference between means - proportion, difference between proportion -
standard deviation, difference between standard deviation -Chi-square test for
goodness of fit - Independence of attributes.
UNIT IV - ANALYSIS OF VARIANCE (12 hours)
Small sample tests based on t and F distribution - Test for, single mean,
difference between means, Paired t-test, test for equality of variances. ANOVA-
one -way classification, Two-way classification.
UNIT V - STATISTICAL QUALITY CONTROL (12 hours)
Introduction - Process control - control charts for variables - X and R, X and s
charts control charts for attributes: p chart, np chart, c chart.
94 Biotech-2013 SRM (E&T)
TEXT BOOK
1. Gupta.S.C and Kapoor.V.K, “Fundamentals of Mathematical Statistics, 11th
extensively revised edition”, Sultan Chand & Sons, 2007.
REFERENCES
1. Gupta.S.C & Kapoor.V.K, “Fundamentals of Applied Statistics”, Sultan Chand
and Sons, New Delhi, 2003.
2. Ewans.W & Grant.G, “Statistical Methods in Bio informatics - An
Introduction”, Springer, 2nd edition,2005.
MA 1034 - BIOSTATISTICS
Course Designed by
Department of Mathematics
1.
Student outcome
a
b
c
d
e
f
g
h
i
j
k
x
x
2.
Mapping of instructional
objectives with student
outcomes
1-5
1-5
3.
Category
General
(G)
Basic Sciences
(B)
Engg. Sci.&
Tech. Arts (E)
Professional
Subjects(P)
x
4.
Approval
23rd Meeting of Academic Council, May 2013
CH1052
CHEMICAL ENGINEERING PRINCIPLES I -
MECHANICAL OPERATIONS AND MOMENTUM
TRANSFER
L
T
P
C
Total No. of Contact Hours - 45
3
0
0
3
Prerequisite
Nil
PURPOSE
This course is concerned with filtration and agitation operations and behavior of
fluids
INSTRUCTIONAL OBJECTIVES
1.
To To understand the basic concepts of filtration and agitation and mixing
2.
To study the nature of fluids and flow characteristics.
3.
To teach knowledge about the fluid transportation and metering devices.
UNIT I - FILTRATION (9 hours)
Introduction: cake filters- Discontinuous pressure filter: principle and working of
filter press- Continuous vacuum filter: principle and working of rotary drum
95 Biotech-2013 SRM (E&T)
filters- Centrifugal Filter: principle and working of suspended batch centrifuges-
filter media- filter aids- principles of cake filtration- pressure drop through filter
cake- compressible and incompressible filter cakes- filter-medium resistance-
constant pressure filtration- continuous filtration- constant rate filtration- working
principle of centrifugal filters.
UNIT II - AGITATION AND MIXING OF LIQUIDS (9 hours)
Dimensional analysis: Buckingham's Πtheorem. -Principles of agitation:
agitation equipment- flow patterns: prevention of swirling- draft tubes. Standard
turbine design- power consumption- power correlation- significance of
dimensionless groups- effect of system geometry- calculation of power
consumption in Newtonian liquids.Blending and mixing: blending of miscible
liquids- blending in process vessels- stratified blending in storage tanks- jet
mixers- motionless mixers- mixer selection.
UNIT III - FLUID FLOW PHENOMENA (9 hours)
Nature of fluids: incompressible and compressible- hydrostatic equilibrium-
manometers- potential flow- boundary layer- the velocity field- laminar flow-
Newtonian and non-Newtonian fluids: Newton's-law of viscosity- turbulence-
Reynolds number and transition from laminar to turbulent flow- Eddy viscosity-
Flow in boundary layers: laminar and turbulent flow in boundary layers-
boundary-layer formation in straight tubes.
UNIT IV - KINEMATICS OF FLOW & FLOW PAST IMMERSED BODIES (9 hours)
Streamlines and stream tubes: equation of continuity- Bernoulli equation- pump
work in Bernoulli equation. Flow of incompressible fluids in conduits and thin
layers- Hagen-Poiseuille equation- von Karman equation- roughness parameter-
friction losses in Bernoulli equation- couette flow. Drag coefficients- drag
coefficients of typical shapes- Ergun equation- terminal settling velocity- Free and
hindered settlings: Stokes' law- Newton's law- criterion for settling regime-
Fluidization: conditions for fluidization- minimum fluidization velocity.
UNIT V - TRANSPORTATION & METERING OF FLUIDS (9 hours)
Introduction to pipe and tubing: joint and fittings- stuffing boxes- mechanical
seals- gate valves and globe valves- plug cocks and ball valves- check valves.-
Classification and selection of pumps: Reciprocating and rotary pumps –
Centrifugal pump– Pump characteristics– Fans- blowers and compressors–Steam
jet ejector.Types of metering devices: Application of Bernouli equation to venturi
meter and orifice meter- flow rate calculations from the readings of venture meter-
orifice meter and pitot tube.
96 Biotech-2013 SRM (E&T)
TEXT BOOKS
1. Warren L. Mccabe, Julian C. Smith and peter Harriott, "Unit Operations of
Chemical Engineering", 6th Edn., McGraw Hill International Edition, New
York, 2001.
2. Coulson.J.M, Richardson.J.F, Backhurst.J.R and Harker.J.M, "Coulson &
Richardson's Chemical Engineering", Vol. II, 4th Edn., Butter worth
Heinemann, Oxford, 1996.
REFERENCES
1. Anup K Swain, Hemalata Patra , Roy.G.K, “Mechanical operations”, Tata -
McGraw Hill, 2010.
2. Noel de Nevers, "Fluid Mechanics for Chemical Engineers", 2nd Edn., McGraw
Hill International Editions.
3. White.F.M, “Fluid Mechanics”, 4th Edn, McGraw-Hill Inc, 1999.
4. Narayanan.C.L & Bhattacharya, "Mechanical Operation for Chemical
Engineering", 1993.
5. Darby.R,”Chemical Engineering Fluid Mechanics”, Marcel Dekker, 1998.
CH1052 CHEMICAL ENGINEERING PRINCIPLES I –
MECHANICAL OPERATIONS AND MOMENTUM TRANSFER
Course Designed by
Department of Chemical Engineering
1.
Student outcomes
a
b
c
d
e
f
g
h
I
j
k
x
x
x
2.
Mapping of instructional
objectives with student
outcomes
1
2
3
3.
Category
General (G)
Basic
Sciences (B)
Engg. Sci. &
Tech. Arts (E)
Professional
Subjects(P)
x
4.
Broad Area
Biotechnology
Bioprocess
Engineering
Chemical Engineering
--
--
--
5.
Approval
23rd Meeting of Academic Council, May 2013
97 Biotech-2013 SRM (E&T)
CH1054
CHEMICAL AND BIOCHEMICAL ENGINEERING
THERMODYNAMICS
L
T
P
C
Total No. of Contact Hours - 45
3
0
0
3
Prerequisite
Nil
PURPOSE
This course helps the students to obtain a proficiency in applying thermodynamic
principles to the solution of a variety of energy flow and equilibrium problems in
chemical and biochemical processes.
INSTRUCTIONAL OBJECTIVES
1.
To understand the basics of First and second laws of thermodynamics
2.
To familiarize the concept of volumetric properties of pure fluids and
vapor/liquid equilibrium
3.
To learn the concept of biochemical thermodynamics and applications
UNIT I - FIRST AND SECOND LAWS OF THERMODYNAMICS (9 hours)
Basic concepts: work, energy, internal energy- First law of thermodynamics:
energy balance for closed systems- equilibrium- the reversible process- constant-
v and constant-p processes- enthalpy- heat capacity- energy balances for steady-
state flow processes. Second law of thermodynamics: statements- heat engines-
Carnot's theorem- ideal-gas temperature scale; Carnot's equations- concept of
entropy- entropy changes of an ideal gas undergoing a mechanically reversible
process in a closed system- mathematical statement of the second law.
UNIT II - VOLUMETRIC PROPERTIES OF PURE FLUIDS (9 hours)
PVT behavior of pure substances- virial equations of state- the ideal gas-
Equations for process calculations: isothermal process- isobaric process-
isochoric process- adiabatic process- and polytropic process. Application of the
virial equations- Introduction to cubic equations of state: van der Waals
equation- Redlich/Kwong equation- theorem of corresponding states.
UNIT III - VAPOR/LIQUID AND CHEMICAL REACTION EQUILIBRIA (9 hours)
The nature of equilibrium- phase rule: Duhem's theorem- Pxy and Txy diagrams-
simple models for VLE- Raoult's law- Dewpoint and bubblepoint calculations with
Raoult's law for binary mixtures- Henry's law- VLE by modified Raoult's law- VLE
from K-value correlations- Flash calculations. Reaction coordinate- application of
equilibrium criteria to chemical reactions- Standard Gibbs-energy change and the
equilibrium constant- Relation of equilibrium constants to composition: gas-
phase reactions- liquid-phase reactions- Equilibrium conversions for single
reactions: single- phase reactions.
98 Biotech-2013 SRM (E&T)
UNIT IV - BIOCHEMICAL THERMODYNAMICS (9 hours)
Bioenergetics: energetics of metabolic pathways- energy coupling (ATP &
NADH)- Stoichiometry and energetic analysis of cell growth and product
formation: i.) elemental balances - degree of reduction concepts- available
electron balances- ii) yield coefficients- iii) oxygen consumption and heat
evolution in aerobic culture- iv) Thermodynamic efficiency of growth.-
Thermodynamics of oxidation:-reduction reactions- Energetics of protein
folding : enzyme -ligand binding.
UNIT V - BIOCHEMICAL APPLICATIONS OF THERMODYNAMICS (9 hours)
Acidity of solutions- Ionization of biochemicals- solubilities of weak acids- bases
and pharmaceuticals as function of pH- Protein concentration in an
ultracentrifuge- Thermodynamic analysis of fermenters and other bioreactors.
TEXT BOOKS
1. Smith.J.M, Van Ness.H.C and Abbott.M.M, "Introduction to Engineering
Thermodynamics", 6th Edn., McGraw Hill International Edition, Singapore
2001.
2. Rao.Y.V.C, "Chemical Engineering Thermodynamics", University Press,
1997.
REFERENCES
1. Stanley I. Sandler, "Chemical and Engineering Thermodynamics", 4th Edn.,
John Wiley & Sons, USA, 2006.
2. Kyle.B.G, "Chemical Process Thermodynamics", 2nd Edn., Prentice Hall of
India Pvt. Ltd., New Delhi, 2000.
CH1054 CHEMICAL AND BIOCHEMICAL ENGINEERING THERMODYNAMICS
Course Designed by
Department of Chemical Engineering
1.
Student outcomes
a
b
c
d
e
f
g
h
i
j
k
x
x
x
2.
Mapping of instructional
objectives with student
outcomes
2
1
3
3.
Category
General(G)
Basic
Sciences (B)
Engg. Sci. &
Tech. Arts (E)
Professional
Subjects (P)
x
4.
Approval
23rd Meeting of Academic Council, May 2013
99 Biotech-2013 SRM (E&T)
BT1014
MOLECULAR BIOLOGY
L
T
P
C
Total No. of Contact Hours - 45
3
0
0
3
Prerequisite
Nil
PURPOSE
To provide the fundamental mechanisms of gene expression and regulation at
molecular level
INSTRUCTIONAL OBJECTIVES
1.
To familiarize the students with the basic concepts and principles of nucleic
acids in prokaryotic and eukaryotic organisms
2.
To understand the structure and machinery of nuclear functions responsible
for cell functioning
UNIT I - INTRODUCTION TO MOLECULAR BIOLOGY– DNA AND RNA (9 hours)
Scope and history -Structure of DNA: Nucleoside – Nucleotide - Base pairing -
Base stacking - Double helix - Features of Watson and crick model - Major and
minor groove - Supercoiling – Twist - Writhe and linking number - Forms of DNA -
A, B, Z - Structure and function of RNAs – mRNA rRNA – tRNA - Secondary
structures in RNA.
UNIT II - REPLICATION AND REPAIR (9 hours)
Replication in prokaryote and eukaryote: Types and function of DNA
polymerases - Proof reading activity - 5΄- 3΄exonuclease activity -
Topoisomerase activity - Telomeric DNA replication and Plasmid replication -
Theta model - Strand replacement model - Rolling circle model - DNA repair:
Nucleotide excision repair - Mismatch repair - Photo-reactivation - Recombination
repair - SOS repair.
UNIT III - TRANSCRIPTION AND POST TRANSCRIPTIONAL MODIFICATIONS
(9 hours)
Fine structure of prokaryotic and eukaryotic genes: Structure and function of the
promoters in mRNA, rRNA, tRNA genes - RNA polymerases in prokaryote and
eukaryote - Types and function of mRNA, rRNA and tRNA genes in prokaryote and
eukaryote - Post transcriptional processing of mRNA: 5’ capping - Splicing
(including different types) - Polyadenylation.
UNIT IV - TRANSLATION AND POST TRANSLATIONAL MODIFICATIONS
(9 hours)
Genetic code and wobble hypothesis-Translation in prokaryote and eukaryote -
Post translational modifications: Principles - Protein sorting - Targeting into
endoplasmic reticulum – Mitochondria - Chloroplast and Nucleus.
100 Biotech-2013 SRM (E&T)
UNIT V - GENE REGULATION (9 hours)
Principles of gene regulation -Transcriptional and post transcriptional gene
regulation: Activators – Co-activators – Suppressors – Co-suppressors –
Moderators – Silencers – Enhancers – Operons:lac operon - trp operon -
araoperon - gal operon.
TEXTBOOK
1. James D Watson, “Molecular Biology of Gene,”Pearson Education, 2011.
REFERENCE
1. Robert Weaver, “Molecular Biology”, McGraw-Hill, 2011.
BT1014 MOLECULAR BIOLOGY
Course Designed by
Department of Biotechnology
1.
Student outcomes
a
b
c
d
e
f
g
h
i
j
K
x
x
2.
Mapping of
instructional objectives
with student outcomes
1
2
3.
Category
General
(G)
Basic
Sciences (B)
Engg. Sci. &Tech.
Arts (E)
Professional
Subjects (P)
x
4.
Broad Area
Biotechnology
Bioprocess
Engineering
Chemical
Engineering
x
--
--
5.
Approval
23rd Meeting of Academic Council, May 2013
BT1016
ENZYME ENGINEERING AND TECHNOLOGY
L
T
P
C
Total No. of Contact Hours - 45
3
0
0
3
Prerequisite
Nil
PURPOSE
The purpose of this course is to provide an opportunity to understand the
theoretical concepts of enzyme technology principles and applications.
INSTRUCTIONAL OBJECTIVES
1.
To understand the basics and mechanisms of enzyme catalysis
2.
To impart knowledge on reaction kinetics of free and immobilized enzymes
3.
To study about the sources, production and industrial applications of
enzymes
101 Biotech-2013 SRM (E&T)
UNIT I - INTRODUCTION TO ENZYMES (8 hours)
Classification of enzymes- Characteristics of enzymes - Structural Components
of Enzymes: Role of Coenzymes and Cofactors- specificity of enzyme action,
Factors affecting enzyme activity: pH- temperature, Enzyme substrate complex
formation models: lock and key- induced fit- Various mechanisms of enzyme
catalysis: acid base- covalent bonding- proximity
UNIT II – ENZYME KINETICS I (10 hours)
Kinetics of single substrate reactions: Michaelis–Menten Kinetics – Evaluation of
Michaelis –Menten parameters- Line Weaver Burk plot- Eadie Hofstee plot -
Hanes woolf plot - Eisenthal and Cornish Bowdon plot - turnover number,
Kinetics of multi-substrate reactions: Ternary-complex mechanisms- Ping–pong
mechanisms.
UNIT III - ENZYME KINETICS II (10 hours)
Kinetics of Enzyme Inhibition: Reversible and irreversible enzyme inhibition -
competitive, uncompetitive and non competitive enzyme inhibition – substrate
and feedback inhibition, Allosteric enzymes: MCW model and KNF model,
Methods of immobilization of enzymes,Kinetics of immobilized enzymes:
Effects of external mass transfer and intra - particle diffusion, Enzyme
Deactivation kinetics.
UNIT IV - PRODUCTION, PURIFICATION AND CHARACTERIZAION OF ENZYMES
(9 hours)
Enzyme sources: Extraction from plant, animal and microbial sources -
Production and purification of intracellular and extracellular industrial
enzymes –Comprehensive flow sheet for enzyme purification: bioseparation
techniques, Analysis of yield, purity and activity of enzymes -Determination of
molecular weight of enzymes: ultracentrifugation, gel filtration, electrophoresis,
MALDI-TOF methods
UNIT V - INDUSTRIAL APPLICATIONS OF ENZYMES (9 hours)
Enzyme reactors-Application of enzymes in food industries: brewing, baking-
Food processing: High fructose corn syrup production- Detergent industry-
Textile industry – leather - pulp and paper industry - Medical and diagnostic
applications of enzymes: Biosensors.
TEXT BOOKS
1. Trevor Palmer and Philip L Bonner. “Enzymes: Biochemistry, Biotechnology,
Clinical Chemistry”, East- West Press, 2004.
2. Shuler, M.L. and F. Kargi, “Bioprocess Engineering: Basic Concepts” 2nd
Edn, Pearson, 2002.
102 Biotech-2013 SRM (E&T)
REFERENCES
1. Blanch.H.W and Clark.D.S, “Biochemical Engineering”. Marcel & Dekker,
Inc., 1997.
2. Bailey.J.E and Ollis.D.F, “Biochemical Engineering Fundamentals”, 2nd
Edition,McGraw-Hill, 1986.
3. Nicholas.C, Price and Lewis Stevens, “Fundamentals of Enzymology”, Oxford
University Press, 1982.
4. Alan Wiseman, “Handbook of Enzyme Biotechnology”, 3rd Ed, Ellis Harwood
Publications, 1999.
BT1016 ENZYME ENGINEERING AND TECHNOLOGY
Course Designed by
Department of Biotechnology
1.
Student outcomes
a
b
c
d
e
f
g
h
i
j
k
x
x
x
2.
Mapping of instructional
objectives with student
outcomes
2
3
1
3.
Category
General
(G)
Basic
Sciences
(B)
Engg. Sci.
&Tech. Arts
(E)
Professional
Subjects
(P)
x
4.
Broad Area
Biotechnology
Bioprocess
Engineering
Chemical
Engineering
--
x
--
5.
Approval
23rd Meeting of Academic Council, May 2013
BT1017
BIOPROCESS PRINCIPLES
L
T
P
C
Total No. of Contact Hours - 45
3
0
0
3
Prerequisite
Nil
PURPOSE
This subject emphasizes on the basic engineering principles of bioprocess. It also
highlights the modern application of biotechnological process and the role of
biotechnology industry.
INSTRUCTIONAL OBJECTIVES
1.
To study the historical development of bio process technology , design of
fermenter and types of fermentation process
2.
To gain knowledge about formulation of medium and principles of sterilization
3.
To study the stoichiometry and energetics of cell growth and product formation
4.
To evaluate the kinetics and mechanism of microbial growth
103 Biotech-2013 SRM (E&T)
UNIT I - INTRODUCTION TO BIOPROCESS (8 hours)
Historical development of bioprocess technologies -role of bioprocess engineer
in the biotechnology industry, Outline of an integrated bioprocess: upstream and
downstream, unit operations involved in bioprocesses, generalized process flow
sheets - A brief survey of organisms -processes and products, Process
economics: market analysis relating to modern industrial biotechnology-
economics of citric acid manufacture.
UNIT II - FERMENTER & FERMENTATION PROCESS (9 hours)
Basic design and construction of fermenter and ancillaries: Tasks of fermenter
-General requirements of fermentation processes: Isolation - preservation and
improvement of industrially important microorganisms - inoculum development
for industrial fermentations. Types of fermentation: An overview of aerobic and
anaerobic fermentation processes and their application in the biotechnology
industry - submerged and solid-state fermentation and its applications.
UNIT III - MEDIA DESIGN AND STERILIZATION KINETICS (9 hours)
Formulation of media for fermentation processes: Types of media- design and
usage of various commercial media for industrial fermentations, Media
optimization: Plackett Burman screening method- Response surface
methodology (RSM), Sterilization: Thermal death kinetics of micro organisms -
batch and continuous heat sterilization of liquid media - filter sterilization of liquid
media and air.
UNIT IV - METABOLIC STOICHIOMETRY AND ENERGETICS (9 hours)
Stoichiometry of cell growth and product formation: elemental balances,
degrees of reduction of substrate and biomass available, electron balances - yield
coefficient of biomass and product formation, maintenance coefficients -
Energetics analysis of microbial growth and product formation: oxygen
consumption and heat evolution in aerobic cultures - thermodynamic efficiency of
growth.
UNIT V - MICROBIAL GROWTH AND PRODUCT FORMATION KINETICS
(10 hours)
Phases of cell growth in batch cultures - Simple unstructured kinetic models for
microbial growth: Monod model, growth of filamentous organisms. Growth
associated (primary) and non-growth associated (secondary) product
formation kinetics: Leudking - Piret models - substrate and product inhibition on
cell growth and product formation.
104 Biotech-2013 SRM (E&T)
TEXT BOOKS
1. Pauline.M.Doran, "Bioprocess Engineering Principles", Academic press,
2012.
2. Stanbury.P.F, Whitaker.A and Hall.S.J, “Principles of Fermentation
Technology”, 2nd Edition, Butterworth– Heinemann, 1995.
REFERENCES
1. Najafpour.G.D, “Biochemical Engineering and Biotechnology”, Elsevier,
2007.
2. Shuler.M.L and Kargi.F, “Bioprocess Engineering: Basic Concepts” 2nd
Edition, Pearson, 2002.
3. Bailey.J.E and Ollis.D.F, “Biochemical Engineering Fundamentals”, 2nd
Edition, McGraw-Hill, 1986.
4. Blanch.H.W and Clark.D.S, “Biochemical Engineering”. Marcel & Dekker,
Inc., 1997.
BT1017 BIOPROCESS PRINCIPLES
Course Designed by
Department of Biotechnology
1.
Student outcomes
a
b
c
d
e
f
g
h
i
j
k
x
x
x
x
2.
Mapping of instructional
objectives with student
outcomes
3
2
4
1
3.
Category
General (G)
Basic
Sciences (B)
Engg. Sci. &
Tech. Arts (E)
Professional
Subjects (P)
x
4.
Broad Area
Biotechnology
Bioprocess Engineering
Chemical
Engineering
--
x
--
5.
Approval
23rd Meeting of Academic Council, May 2013
105 Biotech-2013 SRM (E&T)
CH1053
CHEMICAL ENGINEERING PRINCIPLES-I –
MECHANICAL OPERATIONS AND MOMENTUM
TRANSFER LABORATORY
L
T
P
C
Total No. of Contact Hours - 30
0
0
2
1
Prerequisite
PURPOSE
This course helps the students to experimentally verify the theoretical concepts
they learnt in the course: Chemical Engineering Principles –I
INSTRUCTIONAL OBJECTIVES
1.
To make the students to experimentally evaluate the concepts of unit
operations and momentum transfer.
LIST OF EXPERIMENTS
1. Screening Efficiency
2. Size reduction using Jaw Crusher
3. Leaf Filtration
4. Pressure Filtration
5. Size reduction using Ball Mill
6. Rotary Vacuum Filtration
7. Sink and Float Separation
8. Flow measurement using Orifice Meter
9. Flow measurement using Venturi Meter
10. Performance characteristics of single stage Centrifugal pump
11. Pressure drop study in fluidized bed
12. Drag study
REFERENCE
1. Laboratory manual
106 Biotech-2013 SRM (E&T)
CH1053 CHEMICAL ENGINEERING PRINCIPLES-I – MECHANICAL OPERATIONS AND
MOMENTUM TRANSFER LABORATORY
Course Designed by
Department of Chemical Engineering
1.
Student outcomes
a
B
c
d
e
f
g
h
i
j
k
x
x
x
2.
Mapping of instructional
objective with student
outcomes
1
1
1
3.
Category
General(
G)
Basic
Sciences (B)
Engg. Sci. &
Tech. Arts (E)
Professional
Subjects (P)
x
4.
Approval
23rd Meeting of Academic Council, May 2013
BT1015
MOLECULAR BIOLOGY LABORATORY
L
T
P
C
Total No. of Contact Hours - 60
0
0
4
2
Prerequisite
BT1014
PURPOSE
To provide an opportunity to experimentally verify the theoretical concepts of
nucleic acids
INSTRUCTIONAL OBJECTIVE
1.
The students will perform various experiments to understand the role of
nucleic acids through different techniques.
LIST OF EXPERIMENTS
1. Isolation of genomic DNA from bacteria
2. Plasmid DNA isolation
3. Agarose gel electrophoresis of DNA
4. Polyacrylamide gel electrophoresis of DNA
5. Isolation of RNA
6. Formaldehyde gel electrophoresis of RNA
7. Quantitative analysis of DNA and RNA
8. Restriction digestion of Plasmid DNA
9. Ligation of digested DNA
10. UV mutation
REFERENCE
1. Sambrook et al., “Molecular Cloning” A Laboratory Manual.
107 Biotech-2013 SRM (E&T)
BT1015 MOLECULAR BIOLOGY LABORATORY
Course Designed by
Department of Biotechnology
1.
Student outcomes
a
b
c
d
e
f
g
h
i
j
k
x
x
2.
Mapping of instructional
objectives with student
outcomes
1
2
3.
Category
General (G)
Basic Sciences
(B)
Engg. Sci. &
Tech. Arts (E)
Professional
Subjects (P)
x
4.
Broad Area
Bio-
technology
Bioprocess Engineering
Chemical
Engineering
x
--
--
5.
Approval
23rd Meeting of Academic Council, May 2013
BT1018
BIOPROCESS AND ENZYME TECHNOLOGY
LABORATORY
L
T
P
C
Total No. of Contact Hours - 30
0
0
2
1
Prerequisite
BT1017
PURPOSE
Enables the student to develop their skills in the field of bioprocess to understand
the basic principles using biocatalysts, optimization of parameters for maximum
enzyme activity, kinetic studies, inhibition studies, enzyme immobilization and
microbial fermentation for production of industrial products
INSTRUCTIONAL OBJECTIVES
1.
To develop practical skills in enzyme kinetics and immobilization techniques.
2
To produce various marketable bio products through microbial fermentation
LIST OF EXPERIMENTS
1. Isolation and screening of microorganisms for industrial enzymes
2. Enzyme Kinetics - Batch Study
3. Effect of pH on enzyme activity
4. Effect of temperature on enzyme activity
5. Effect of inhibitors on enzyme activity
6. Immobilization of enzymes – Entrapment Method
7. Comparison of free and immobilized enzyme kinetics
108 Biotech-2013 SRM (E&T)
8. Bioreactor operation – Demonstration
9. Batch Experiment for production of viable bio products
10. Ethanol fermentation in an immobilized cell reactor using Saccharomyces
cerevisiae
11. Production of Citric acid by Aspergillus niger by Solid Substrate Fermentation
REFERENCE
1. Laboratory Manual
BT1018 BIOPROCESS AND ENZYME TECHNOLOGY LABORATORY
Course Designed by
Department of Biotechnology
1.
Student outcomes
a
b
c
d
e
f
g
h
i
j
k
x
x
2.
Mapping of instructional
objective with student
outcomes
1
2
3.
Category
General (G)
Basic
Sciences (B)
Engg. Sci.
&Tech. Arts (E)
Professional
Subjects (P)
x
4.
Broad area
Biotechnology
Bioprocess
Engineering
Chemical Engineering
--
x
--
5.
Approval
23rd Meeting of Academic Council, May 2013
109 Biotech-2013 SRM (E&T)
SEMESTER - V
PD1005
APTITUDE-III
L
T
P
C
Total Contact Hours - 30
1
0
1
1
Prerequisite
Nil
PURPOSE
To enhance holistic development of students and improve their employability
skills.
INSTRUCTIONAL OBJECTIVES
1.
Understand the importance of effective communication in the workplace.
2.
Enhance presentation skills – Technical or general in nature.
3.
Improve employability scope through Mock GD, Interview
UNIT I (6 hours)
Video Profile
UNIT II (6 hours)
Tech Talk / Area of Interest / Extempore / Company Profile
UNIT III (6 hours)
Curriculum Vitae
UNIT IV (6 hours)
Mock Interview
UNIT V (6 hours)
Group Discussion / Case Study
ASSESSMENT
1. Objective type – Paper based / Online – Time based test
2. 50% marks based on test, 50 % based on Continuous Communication
assessment
REFERENCE
1. Bovee Courtland and Throill John, Business Communication Essentials: A
skills-Based Approach to Vital Business English. Pearson Education Inc.,
2011
2. Dhanavel.S.P, English & Communication Skills for Students of Science and
Engineering. Orient Black Swan, 2009
3. Rizvi M. Ashraf Effective Technical Communication, Tata McGraw-Hill
Publishing Company Limited, 2006.
110 Biotech-2013 SRM (E&T)
PD1005 – APTITUDE-III
Course Designed by
Career Development Centre
1.
Student outcome
a
b
c
d
e
f
g
h
i
j
k
x
x
x
2.
Mapping of instructional
objectives with student
outcome
1,2,3
1,2
2,3
3.
Category
General(G)
Basic
Sciences(B)
Engineering
Sciences and
Technical Arts(E)
Professional
Subjects(P)
x
4.
Approval
23rd Meeting of Academic Council, May 2013
CH1055
CHEMICAL ENGINEERING PRINCIPLES II -
HEAT AND MASS TRANSFER
L
T
P
C
Total No. of Contact Hours - 45
3
0
0
3
Prerequisite
Nil
PURPOSE
This course explains the fundamentals of heat and mass transfer operations.
INSTRUCTIONAL OBJECTIVES
1.
o To understand the basic concepts of conductive and convective heat transfer
and heat exchange equipment’s.
2.
To familiarize the mass transfer operations like diffusion, drying and
distillation
3.
To understand the principles extraction and adsorption processes involved in
industries.
UNIT I - CONDUCTIVE & CONVECTIVE HEAT TRANSFER (9 hours)
Introduction to various modes of heat transfer: Fourier's law of heat conduction,
effect of temperature on thermal conductivity- steady-state conduction-
compound resistances in series- heat flow through a cylinder. Concept of heat
transfer by convection: natural and forced convection- application of dimensional
analysis for convection- heat transfer to fluids without phase change: heat transfer
coefficient calculation for natural and forced convection- Heat transfer to fluids
with phase change: heat transfer from condensing vapours- dropwise and film-
type condensation- Heat transfer coefficients calculation for film:-type
condensation.
111 Biotech-2013 SRM (E&T)
UNIT II - HEAT-EXCHANGE EQUIPMENTS (8 hours)
Typical heat exchange equipment: counter current and parallel-current flows-
Enthalpy balances: heat exchanges- total condensers. -Double pipe exchanger-
single-pass 1-1 exchanger- 1-2 parallel-counterflow exchanger- 2-4 exchanger-
heat-transfer coefficients in shell-and-tube exchanger- coefficients for crossflow-
correction of LMTD for crossflow.-Condensers: shell-and-tube condensers-
kettle-type boilers- Calculation of number of tubes in heat exchangers.
UNIT III - DIFFUSION (8 hours)
Molecular diffusion: steady state molecular diffusion in fluids at rest and in
laminar flow- molecular diffusion in gases-steady state diffusion: of A through non
diffusing B- equimolal counter diffusion- in multicomponent mixtures. Molecular
diffusion in liquids-steady state diffusion: of A through nondiffusing B- equimolal
counter diffusion. Effect of temperature and pressure on diffusivity.
UNIT IV - DRYING & DISTILLATION (10 hours)
Importance of drying in processes: principles of drying- critical moisture content
and falling-rate period- porous solids and flow by capillarity- calculation of drying
time under constant drying conditions.-Classification of dryers: solids handling in
dryers- Equipments for batch and continuous drying processes: working
principle of tray driers- tower driers- rotary driers- spray driers. Concept of freeze
drying. -Basic concepts of various methods of distillation: batch- continuous-
flash- steam- azeotropic and vacuum distillations- Design calculations by
McCabe-Thiele and Ponchon-Savarit methods.
UNIT V - EXTRACTION & ADSORPTION (10 hours)
Extraction-basics:working principle of extraction equipments: mixersettlers- spray
and packed extraction towers- agitated tower extractors. General principles of
leaching: working principle of moving-bed leaching equipments: Bollman
extractor- Hildebrandt extractor. Percentage extraction calculation for single stage
and multistage crosscurrent operations when liquids are insoluble.Minimum
solvent rate and number of theoretical stages for continuous countercurrent-
multistage extraction operation when liquids are insoluble.Introduction to
adsorption: adsorbents and adsorption processes- adsorption equipment: fixed-
bed adsorbers- gas-drying equipment. Pressure-swing adsorption- adsorption
from liquids- adsorption isotherms.
112 Biotech-2013 SRM (E&T)
TEXT BOOKS
1. Warren L. Mccabe, Julian C. Smith and Peter Harriott, "Unit Operations of
Chemical Engineering", 6thEdn., McGraw Hill, New York, 2001.
2. Robert E. Treybal, "Mass-Transfer Operations",3rd Edn., McGraw Hill
International Ed., Singapore, 1980.
REFERENCES
1. Coulson.J.M, Richardson. J.F, Backhurst.J.R and Harker.J.M, "Coulson &
Richardson's Chemical Engineering", Vol. I, 6th Edn., Butter worth
Heinemann,1999.
2. Binay K.Dutta “Heat Transfer Principles and Applications”, Prentice Hall of
India, 2001.
3. Kern.D.Q, “Process Heat Transfer”, McGraw-Hill, 1999.
CH1055 CHEMICAL ENGINEERING PRINCIPLES II - HEAT AND MASS TRANSFER
Course Designed by
Department of Chemical Engineering
1.
Student outcomes
a
b
c
d
e
f
G
h
I
j
k
x
x
x
2.
Mapping of instructional
objectives with student
outcomes
3
2
1
3.
Category
General(G)
Basic Sciences
(B)
Engg. Sci. &
Tech. Arts (E)
Professional
Subjects (P)
x
4.
Approval
23rd Meeting of Academic Council, May 2013
113 Biotech-2013 SRM (E&T)
CH1056
CHEMICAL ENGINEERING PRINCIPLES -II
HEAT AND MASS TRANSFER LABORATORY
L
T
P
C
Total No. of Contact Hours - 30
0
0
2
1
Prerequisite
Nil
PURPOSE
This course helps the students to experimentally verify the theoretical concepts
they learnt in the course: Chemical Engineering Principles –II
INSTRUCTIONAL OBJECTIVES
1.
To make the students to experimentally evaluate the concepts of hear
transfer process and mass transfer operations
LIST OF EXPERIMENTS
1. Natural and forced convection heat transfer
2. Heat transfer in a jacketed kettle
3. Study of single effect evaporator
4. Study of shell and tube heat exchanger
5. Heat transfer in agitated vessel
6. Extraction
7. Leaching
8. Batch adsorption
9. Diffusion
10. Air drying
REFERENCE
1. Laboratory manual
CH1056 CHEMICAL ENGINEERING PRINCIPLES-II – HEAT AND MASS TRANSFER
LABORATORY
Course Designed by
Department of Chemical Engineering
1.
Student outcomes
a
b
c
d
E
f
g
h
i
j
k
x
x
x
2.
Mapping of instructional
objective with student
outcomes
1
1
1
3.
Category
General(G)
Basic
Sciences (B)
Engg. Sci. &
Tech. Arts (E)
Professional
Subjects (P)
x
4.
Approval
23rd Meeting of Academic Council, May 2013
114 Biotech-2013 SRM (E&T)
BT1019
VECTOR BIOLOGY AND GENE MANIPULATION
L
T
P
C
Total No. of Contact Hours - 45
3
0
0
3
Prerequisite
Nil
PURPOSE
To provide the basic knowledge about genetic engineering for cloning and
expression of proteins
INSTRUCTIONAL OBJECTIVES
1.
To familiarize the students with the basic concepts and principles of
utilization of different expression vectors for cloning in prokaryotic and
eukaryotic organisms
2.
To better understand the different strategies of gene cloning and construction
of genomic and cDNA libraries for applications of recombinant DNA
technology
UNIT I - INTRODUCTION TO CLONING (9 hours)
Overview of cloning: Cell based DNA cloning - Cell free DNA cloning - Plasmid
vectors: Phage vectors – Cosmids – YAC- Expression vectors.
UNIT II - GENOMIC AND CDNA LIBRARIES (9 hours)
Genomic DNA library: Overlapping and non-overlapping DNA fragments - Choice
of vectors - Evaluation of genomic DNA library - cDNA library: Purification and
separation of RNAs - cDNA library construction - Screening libraries -
Polymerase chain reaction (PCR): Semi quantitative PCR - Real time PCR and
Applications.
UNIT III - DNA SEQUENCING AND NUCLEIC ACIDS LABELING (9 hours)
Principles of DNA sequencing: Sanger’s Dideoxy sequencing method - Maxam
and Gilbert’s chemical sequencing method - Labeling of nucleic acids: Random
priming - Nick translation - End labeling - RNA labeling - Non-isotopic labeling
methods.
UNIT IV - ANALYSIS AND MANIPULATION OF GENE EXPRESSION AND
FUNCTION (9 hours)
Analysis of gene expression: Transcription and translation - Analysis of gene
function -Manipulation of gene expression: Small RNAs – siRNAs - MicroRNAs
-Expression in prokaryotic and eukaryotic host cells:in vitro mutagenesis.
115 Biotech-2013 SRM (E&T)
UNIT V - APPLICATIONS OF CLONING (9 hours)
Medical applications: Vaccines - Human and genetic diseases - Embryonic stem
cells - Over-expression - Gene knock-in - Gene knock-out.
TEXTBOOK
1. Jeremy W. Dale and Malcolm von Schantz, “From Genes to Genomes,” John
Willey and Sons Publications, 2002.
REFERENCE
1. Old.R.W and Primrose.S.B, “Principles of Gene Manipulation, An Introduction
to Genetic Engineering,” Blackwell Scientific Publications.
BT1019 VECTOR BIOLOGY AND GENE MANIPULATION
Course Designed by
Department of Biotechnology
1.
Student outcomes
a
b
c
d
e
f
g
h
i
J
k
x
x
2.
Mapping of instructional
objectives with student
outcomes
1
2
3.
Category
General (G)
Basic
Sciences (B)
Engg. Sci.
&Tech. Arts (E)
Professional
Subjects (P)
x
4.
Broad Area
Bio-
technology
Bioprocess Engineering
Chemical
Engineering
x
--
--
5.
Approval
23rd Meeting of Academic Council, May 2013
BT1021
ANIMAL BIOTECHNOLOGY
L
T
P
C
Total No. of Contact Hours - 45
3
0
0
3
Prerequisite
Nil
PURPOSE
To provide a basic understanding of animal biotechnology and its applications
INSTRUCTIONAL OBJECTIVES
1.
To impart knowledge on production of transgenic animals and how to
improve the meat and milk production.
2.
To inculcate the understanding of cell culture technique, significance of its
cultivation and its application in the production of valuable products.
3
To develop an understanding on basic pattern of animal breeding, controlling
characters and disorders.
116 Biotech-2013 SRM (E&T)
UNIT I - ANIMAL BREEDS (7 hours)
Introduction: Breed: Species-different types of breeding, upgrading, Economic
traits- Genetic characterization of live stock breeds - Quantitative trait loci- Marker
assisted selection. Genetic disorders - Chromosomal aberrations in farm
animals.
UNIT II - EMBRYO TRANSFER AND TRANSGENIC ANIMALS (8 hours)
Embryo transfer:Artificial insemination, Superovulation, Embryo transfer, In vitro
fertilization - Pregnancy diagnosis - Sexing of embryos, Embryo splitting;
Cryopreservation of embryo; Cloning for conservation of endangered species -
Transgenic animals: Therapeutic protein expression using transgenic animals -
Transgenic fish - Animal as bioreactors.
UNIT III - ANIMAL CELL CULTURE (12 hours)
Principles of sterile techniques and cell propagation;Primary cell culture,
secondary cell culture, continuous cell lines, suspension cultures - Chemically
defined and serum free media for cell culture -Scaling up of animal cell
cultures;Contamination : sources, types and eradication -Preservation of
animal cells -organotypic culture -Application of animal cell culture for in
vitro testing of drugs: Cytotoxicity and viability assays - Cell culture as source
of valuable products - Protein production by genetically engineered mammalian
cell lines.
UNIT IV - RECOMBINANT VACCINES FOR ANIMAL HEALTH (8 hours)
Common viral, bacterial and parasitic diseases affecting animals-Types of
Vaccines - Live vaccines, killed vaccines- Conjugate vaccines – Anti-Idiotypic
vaccine - Subunit vaccines- Recombinant vaccines - DNA vaccines.
UNIT V - BIOTECHNOLOGY IN ANIMAL PRODUCTION (10 hours)
Manipulation of Growth hormone -somatotropic hormone-Thyroid hormone;
Probiotics as growth promoters - Ideal characteristics of probiotics, Mode of
action-uses of probiotics-Manipulation of lactation – Lactogenesis-
galactopoiesis - Manipulation of wool growth-Manipulation of rumen microbial
digestive system.
117 Biotech-2013 SRM (E&T)
TEXTBOOKS
1. Freshney.R.I, “Culture of Animal cells: A manual of basic technique”, Fifth
edition, Wiley Publishers, 2010.
2. Ramadass.P, “Animal Biotechnology: Recent concepts and Developments”,
MJP Publications, India, 2008.
REFERENCES
1. Leach.C.K, “In vitro cultivation of Animal cells”, Butterworth and
Heinnmamm Ltd., 1994.
2. Renaville.R and Burny.A, “Biotechnology in Animal husbandry”, Kluwer
Academic Publishers, 2001.
BT1021 ANIMAL BIOTECHNOLOGY
Course Designed by
Department of Biotechnology
1.
Student outcomes
a
b
C
d
e
f
g
h
i
J
k
x
x
x
x
2.
Mapping of instructional
objectives with student
outcomes
1,3
3
2
2
3.
Category
General
(G)
Basic
Sciences (B)
Engg. Sci.
&Tech. Arts (E)
Professional
Subjects (P)
x
4.
Broad Area
Bio-
technology
Bioprocess Engineering
Chemical
Engineering
x
--
--
5.
Approval
23rd Meeting of Academic Council, May 2013
BT1022
PLANT BIOTECHNOLOGY
L
T
P
C
Total No. of Contact Hours - 45
3
0
0
3
Prerequisite
Cell Biology, Biochemistry, Molecular Biology
PURPOSE
The course is tailored to provide an understanding of the basic concepts and state
of art techniques and methods underlying plant biotechnology research including
the genetic basis of several important plant properties and the molecular basis of
plant breeding. The students will gain an understanding of theoretical principles
enabling them to employ the knowledge to solve problems related to plant
production and protection through biotechnological approaches.
118 Biotech-2013 SRM (E&T)
INSTRUCTIONAL OBJECTIVES
1.
To explore the structural complexity and diversity of plants
2.
To present an overview of plant tissue culture and genetic manipulation of
plants
3.
To impart knowledge in principles underlying plant metabolism
4.
To understand the modern technologies underlying plant breeding and plant
protection
5.
To appreciate the utility of plants as production systems
UNIT I - FROM CELLS TO PLANTS (9 hours)
Evolution of plant diversity - variation in plant populations and species –speciation
origins of reproductive isolating mechanisms -species concepts -morphology
anatomy and embryology - overview of plant phylogeny -phylogenetic
relationships of angiosperms- molecular systematics
UNIT II - TECHNIQUES FOR GENETIC MANIPULATION OF PLANTS (9 hours)
Introduction- Agrobacterium mediated gene transfer –Ti-plasmid-process of T-
DNA transfer and integration, transformation in plant, Direct gene transfer
methods. Binary vectors- basic features of vectors-optimization-clean gene
technology.
UNIT III - METABOLIC PLANT PHYSIOLOGY (9 hours)
Overview of photosynthesis.- Light absorption and energy conversion; the
reaction center complex; the photosystem - Carbon reactions in C3plants –
Photorespiration - Variations in mechanisms of CO2fixation- Carbohydrate
metabolism- sucrose and starch- cell wall polysaccharides- non-starch storage
polysaccharides Nitrogen and sulphur metabolism- Transport processes
UNIT IV - PLANT BREEDING AND PLANT PROTECTION (9 hours)
Plant reproductive systems- germplasm - variation- types and origin - Plant
genetic resources for plant breeding- Sexual hybridization and wide crosses-
Mutagenesis - Polyploidy- selected breeding objectives- Cultivar release and
commercial seed production. Biotic stress factors- plant-pathogen interactions-
natural disease resistance pathways- abiotic stress factors - tolerance
mechanisms
119 Biotech-2013 SRM (E&T)
UNIT V - PLANTS AS PRODUCTION SYSTEMS (9 hours)
Plant tissue culture-plasticity and totipotency, culture environment, growth
regulators, media regulators, culture types, plant regeneration - Hairy root
cultures - production of secondary metabolites-carbohydrate and lipid production-
molecular pharming of proteins - emerging applications for producing fine
chemicals, drugs, and alternative fuels.
TEXT BOOKS
1. Taiz. L and Zeigler.E, “Plant Physiology,” . Panima Publishing Corporation,
New Delhi, Third edition. 2003.
2. Salisbury. F.B and Ross.C.W, “Plant Physiology”, Wadsworth Publishing
Company Fourth edition 1992.
3. Slater. A, Scott.N.W and Fowler.M.R, “Plant Biotechnology - The genetic
manipulation of plants”, Oxford University press 2008.
4. Robert Wayne Allard John, “Principles of Plant Breeding”, Wiley & Sons
Second edition 1999.
REFERENCES
1. Murray.D.R, “Advanced methods in plant breeding and biotechnology” CAB
International 1991.
2. Stephanopolous.G.N, Aristidou. A.A and Neilsen.J, “Metabolic engineering-
Principles and Methodologies,” Academic Press 1998.
3. Smolke.C, “The metabolic pathway engineering- Tools and applications” -
CRC Press 2009.
BT1022 PLANT BIOTECHNOLOGY
Course Designed by
Department of Biotechnology
1.
Student outcomes
a
b
c
d
E
f
g
h
i
j
k
x
x
x
x
x
2.
Mapping of instructional
objectives with student
outcomes
1-5
1-5
1-5
1-5
1-5
3.
Category
General
Subjects (G)
Basic
Sciences(B)
Engg. Sci. &
Tech. Arts(E)
Professional
Subjects(P)
x
4.
Broad Area
Biotechnology
Bioprocess Engineering
Chemical
Engineering
x
5.
Approval
23rd Meeting of Academic Council, May 2013
120 Biotech-2013 SRM (E&T)
BT1024
ENVIRONMENTAL BIOTECHNOLOGY
L
T
P
C
Total No. of Contact Hours – 45
3
0
0
3
Prerequisite
Nil
PURPOSE
The purpose of this course is to provide an understanding of fundamental
concepts and underlying principles in the Environmental sciences. In addition, the
course covers the application of biology-based technologies for bioenergy and
bio-remediation.
INSTRUCTIONAL OBJECTIVES
1.
To understand the role of various environmental pollutants and its effects.
2.
To focus the involvement of microbes in waste water treatments.
3.
To focus the role of microorganisms involved in toxic compound
degradations.
4.
To focus the role of environmental enzymes in environmental applications
5.
To focus the status of solid waste management’s.
UNIT I - WASTE & POLLUTANTS (9 hours)
Source of Waste and Pollutants; Hazardous from Waste and Pollutants; Waste
Treatment- Biofilters, Treatment of Liquid wastes, Treatment of Solid wastes,
Contributions of Biotechnology to waste treatment and Environmental
Managements.
UNIT II - WASTE WATER BIOTREATMENT (9 hours)
Characteristics of Waste Waters; Aerobic and Anaerobic waste water treatment:
Activated Sludge Process and Natural Treatment Systems; Stoichiometry and
Bioenergetics ; Anaerobic Digestion; Nitrogen Removal and Anammox;
Phosphorus Removal and EBPR.
UNIT III - BIODEGRADATIONOF XENOBIOTIC COMPOUNDS (9 hours)
Xenobiotic compounds: Types of Recalcitrant xenobiotic compounds.
Biodegradation of Xenobiotics. Hydrocarbons and their derivatives: Aliphatic,
Aromatic, Polycyclic compounds. Methods of biodegradation of xenobiotics.
Reductive/oxidative/hydrolytic.
UNIT IV - ENVIRONMENTAL ENZYMES AND BIOCATALYSTS (9 hours)
Biocatalyst Discovery: Sources and Techniques: Isolated Enzymes versus whole
cell systems; Biocatalyst Engineering, Industrial applications of enzyme based
121 Biotech-2013 SRM (E&T)
biocatalysis. Classification of enzymes: Oxidoreductases, Transferases,
Hydrolases, Lyases, Isomerases, Ligases. Advantages and Disadvantages of
Biocatalysis vs. Chemical Catalysis;
UNIT V - SOLID WASTE MANAGEMENT (9 hours)
Definition of solid wastes –– types of domestic solid wastes – collection –
transportation – characteristics of solid waste–segregation – types of disposal
methods – sanitary land fill – incineration – composting – Vermicompost –
recovery of energy from solid wastes. Biocontrol agents- Bioherbicides &
Biopesticides, Biofertilizers.
TEXT BOOKS
1. Bruce E. Rittmann, Perry L. McCarty, “Environmental Biotechnology:
Principles and Applications” McGraw-Hill, 2001.
2. Michael D. LaGrega,Phillip L. Buckingham, Jeffrey C. Evans, “Hazardous
Waste Management,” Waveland Pr Inc; Reissue edition, 2010.
3. Chatterjee.A.K, “Introducton to Environmental Biotechnology,” Prentice-Hall
of India, 2004.
4. Jogdand.S.N, “Environmental biotechnology: industrial pollution
management,” Himalaya Publishing, 2005.
REFERENCE
1. Leslie Grady Jr C. P., Glen T. Daigger, Nancy G. Love, Carlos D. M. Filipe,
“Biological Wastewater Treatment,” Third Edition, CRC Press, 2011.
BT1024 ENVIRONMENTAL BIOTECHNOLOGY
Course Designed by
Department of Biotechnology
1.
Student outcomes
a
b
c
d
e
f
g
h
i
J
k
x
x
2.
Mapping of instructional
objectives with student
outcomes
1
4
2
3.
Category
General
Subjects (G)
Basic
Sciences B)
Engg. Sci. &
Tech. Arts (E)
Professional
Subjects (P)
x
4.
Broad Area
Biotechnology
Bioprocess
Engineering
Chemical Engineering
x
--
--
5.
Approval
23rd Meeting of Academic Council, May 2013
122 Biotech-2013 SRM (E&T)
BT1020
VECTOR BIOLOGY AND GENE MANIPULATION
LABORATORY
L
T
P
C
Total No. of Contact Hours - 60
0
0
4
2
Prerequisite
BT1019
PURPOSE
To provide an opportunity to experimentally verify the theoretical concepts of gene
cloning and protein expression
INSTRUCTIONAL OBJECTIVE
1.
The students will perform various experiments on gene cloning and protein
expression through different techniques.
LIST OF EXPERIMENTS
1. Preparation of DNA fragments by PCR
2. Restriction enzyme digestion of vector DNA
3. Purification of DNA fragments/digested vector DNA by column purification
4. Preparation of target DNA by linker/adapters/alkaline phosphatase treatment
for cloning
5. Ligation of DNA fragment with cloning vector
6. Preparation of E. coli competent cells
7. Bacterial transformation with recombinant vector
8. Preparation of recombinant and non-recombinant vector DNAs
9. Confirmation of insert DNA in recombinant vector
10. Mammalian cell transfection
11. Polyacrylamide gel electrophoresis for protein
12. Western blot analysis
REFERENCE
1. Sambrook et al., ‘Molecular Cloning’ A Laboratory Manual’
123 Biotech-2013 SRM (E&T)
BT1020 VECTOR BIOLOGY AND GENE MANIPULATION LABORATORY
Course Designed by
Department of Biotechnology
1.
Student outcome
a
b
c
d
e
f
g
h
i
j
k
2.
Mapping of instructional
objectives with student
outcome
x
x
x
x
3.
Category
General(G)
Basic
Sciences(B)
Engineering
Sciences and
Technical Arts (E)
Professional
Subjects(P)
x
4.
Broad Area
Biotechnology
Bioprocess
Engineering
Chemical Engineering
x
--
--
5.
Approval
23rd Meeting of Academic Council, May 2013
BT1023
PLANT BIOTECHNOLOGY LABORATORY
L
T
P
C
Total No. of Contact Hours – 60
0
0
4
2
Prerequisite
BT1022
PURPOSE
To facilitate understanding of the practical use of and theory behind the emerging
techniques in the field of plant biotechnology enabling practice of the gained
knowledge to solve problems related to plant production through biotechnological
approaches.
INSTRUCTIONAL OBJECTIVES
1.
To give students hands-on experience and training in representative plant
tissue culture techniques and an insight to explore the applications.
2.
To develop strategies and models to solve problems relating to plant
biotechnology by using fundamental principles in plant biotechnology.
3.
To give a practical hand-on experience related to advanced techniques and
equipment used in plant biotechnology.
4.
To employ advanced technologies in plant biotechnology such as genetic
modification and molecular genetics.
5.
To put into perspective and discuss the potential applications of plant
biotechnology.
124 Biotech-2013 SRM (E&T)
LIST OF EXPERIMENTS
1. Preparation of tissue culture medium and callus induction
2. Demonstration of direct and indirect organogenesis
3. In vitro and in vivo embryogenesis
4. Protoplas isolation, electrofusion and regeneration
5. Agrobacterium mediated transformation
6. Demonstration of electroporation
7. Extraction and detection of nucleic acids from plants
8. 2-D Gel electrophoresis for separation of plant proteins and peptides
9. Understanding plant pathogen interactions using confocal microscopy
10. Production of secondary metabolites in suspension cultures
11. Purification and quantitation of secondary metabolites using TLC and HPLC
12. SNP based multiplex PCR
REFERENCES
1. Plant Biotechnology Laboratory Manual.
2. Protocols in Plant Biotechnology.
BT1023 PLANT BIOTECHNOLOGY LABORATORY
Course Designed by
Department of Biotechnology
1.
Student outcomes
a
b
c
d
e
F
G
h
i
j
k
2.
Mapping of instructional
objective with Student
outcomes
1
1
1
3.
Category
General
Subjects (G)
Basic
Sciences (B)
Engg. Sci. &
Tech. Arts(E)
Professional
Subjects (P)
x
4.
Broad area
Biotechnology
Bioprocess
Engineering
Chemical Engineering
x
--
5.
Approval
23rd Meeting of Academic Council, May 2013
125 Biotech-2013 SRM (E&T)
BT1047
INDUSTRIAL TRAINING I
(Training to be undergone after IV semester)
L
T
P
C
2 weeks practical training in industry
0
0
1
1
Prerequisite
Nil
PURPOSE
To provide hands-on experience by working in biotechnology related industries
INSTRUCTIONAL OBJECTIVES
1.
Students have to undergo practical training in bioengineering industries or
training institutes so that they become aware of the practical application of
theoretical concepts studied in the class rooms
Students have to undergo two-weeks practical training in biotechnology related
project of their choice but with the approval of the department. At the end of the
training student will submit a report as per the prescribed format to the
department.
Assessment process
This course is mandatory and the student has to pass the course to become
eligible for the award of degree. The student shall make a presentation before a
committee constituted by the department which will assess the student based on
the report submitted and the presentation made. Marks will be awarded out of 100
and appropriate grades assigned as per the regulations.
BT1047 INDUSTRIAL TRAINING I
Course Designed by
Department of Biotechnology
1.
Student outcome
a
b
c
d
e
f
g
h
i
j
k
x
x
x
x
x
x
2.
Mapping of instructional
objective with student
outcome
1
1
1
1
1
1
3.
Category
General
Subjects (G)
Basic
Sciences (B)
Engg. Sci. &
Tech. Arts(E)
Professional
Subjects (P)
x
4.
Broad area
Biotechnology
Bioprocess
Engineering
Chemical Engineering
x
--
5.
Approval
23rd Meeting of Academic Council, May 2013
126 Biotech-2013 SRM (E&T)
SEMESTER - VI
PD1006
APTITUDE-IV
L
T
P
C
Total Contact Hours - 30
1
0
1
1
Prerequisite
Nil
PURPOSE
To enhance holistic development of students and improve their employability
skills.
INSTRUCTIONAL OBJECTIVES
1.
To improve aptitude, problem solving skills and reasoning ability of the
student.
2.
To collectively solve problems in teams & group.
UNIT I - ARITHMETIC - II (6 hours)
Ratios & Proportions, Averages, Mixtures & Solutions
UNIT II - ARITHMETIC – III (6 hours)
Time, Speed & Distance, Time & Work
UNIT III - ALGEBRA – II (6 hours)
Quadratic Equations, Linear equations & inequalities
UNIT IV - GEOMETRY (6 hours)
2D Geometry, Trigonometry, Mensuration
UNIT V - MODERN MATHEMATICS – II (6 hours)
Sets & Functions, Sequences & Series, Data Interpretation, Data Sufficiency
ASSESSMENT
1. Objective type – Paper based / Online – Time based test
REFERENCES
1. Agarwal.R.S , “Quantitative Aptitude for Competitive Examinations”, S Chand
Limited 2011
2. Abhijit Guha, “Quantitative Aptitude for Competitive Examinations”, Tata
Mcgraw Hill, 3rd Edition
3. Edgar Thrope, “Test Of Reasoning For Competitive Examinations”, Tata
Mcgraw Hill, 4th Edition
4. “Other material related to quantitative aptitude”
127 Biotech-2013 SRM (E&T)
PD1006 - APTITUDE-IV
Course Designed by
Career Development Centre
1.
Student outcome
a
b
c
d
e
f
g
h
i
j
k
x
x
2.
Mapping of instructional
objectives with student
outcome
1
2
3.
Category
General(G)
Basic
Sciences(B)
Engineering Sciences
and Technical Arts(E)
Professional
Subjects(P)
x
4.
Approval
23rdMeeting of Academic Council, May 2013
BT1026
PHARMACEUTICAL BIOTECHNOLOGY
L
T
P
C
Total No. of Contact Hours – 45
3
0
0
3
Prerequisite
Nil
PURPOSE
The PURPOSE of this course is to provide basic concepts of pharmacology and
the role of biotechnological products in pharmaceutical industries. The course
ensures to impart brief knowledge on current technologies, requirements and
futuristic demand in pharmaceutical sector.
INSTRUCTIONAL OBJECTIVES
1.
To highlight the parameters considered for drug action and drug discovery
process.
2.
To understand the current procedures for the manufacture of various
chemicals, biological and pharmaceutical products.
3.
To realize the potential avenues and requirements from the biotechnologists
in pharmaceutical industries.
UNIT I - GENERAL PHARMACOLOGY (9 hours)
Introduction, Pharmacokinetics – Absorption, Distribution, Metabolism, Excretion
and Toxicology. Pharmacodynamics – signal transduction, GPCR’s, Ion channels,
Steroid receptors and peptide receptors. Efficacy vs Potency, therapeutic window
and dosage calculation.
UNIT II - INDUSTRIALLY RELEVANT MICROBIAL METABOLITES (8 hours)
Process technology for the production of both primary and secondary
metabolites; organic solvent – alcohol, acid – lactic acid and citric acid, amino
acids – glutamic acid and lysine, vitamins – riboflavin and vit. B12, nucleotides –
cAMP and cGMP.
128 Biotech-2013 SRM (E&T)
UNIT III - CHEMOTHERAPEUTICS (9 hours)
Structure, Mechanism of Action and production of antibiotics – Penicillin and
Cephalosporins (beta lactam antibiotics), Griseofulvin, Streptomycin, Rifampicin,
Amphotericin B and Mitomycin C.
UNIT IV - GENETICALLY ENGINEERED BIOPHARMACEUTICALS (9 hours)
Industrial production of (A) interferon, interleukins (regulatory proteins) (B)
Erythropoietin (blood products) (C) Hepatitis B vaccine (D) insulin hormone.
Various routes of administration, controlled and targeted drug delivery of
therapeutic proteins and peptides.
UNIT V - IMMUNOBIOTECHNOLOGY (8 hours)
Hybridoma technology – selection, screening and fusion methods for myeloma
cells and B lymphocytes. Production, purification and application of monoclonal
antibodies.Introduction to second generation antibodies and lymphokines.
TEXTBOOKS
1. Tripathi.C.P, “Essentials of Medical Pharmacology,” 6th Edition, Jaypee
publications, 2008.
2. Hugo..W.B and Russel.A.D, “Pharmaceutical Microbiology”, 6th Edition,
Blackwell Science, 2003.
3. Crommelin.D.J.A, Robert D. Sindela, Bernd Meibohm “Pharmaceutical
Biotechnology: fundamentals and applications”, Informa Healthcare, 2008.
REFERENCES
1. Gary Walsh, “Pharmaceutical Biotechnology-Concepts and Applications,”
Wiley, 2007.
2. Stanbury.P.F, Whitaker.A and Hall.S.J, “Principles of Fermentation
Technology”, 2nd Edition, Aditya Books (P) Ltd, 1995.
BT1026 PHARMACEUTICAL BIOTECHNOLOGY
Course Designed by
Department of Biotechnology
1.
Student outcomes
a
b
c
d
e
f
g
h
i
J
k
x
x
x
2.
Mapping of instructional
objectives with Student
outcomes
1
2
3
3.
Category
General
Subjects (G)
Basic
Sciences B)
Engg. Sci. &
Tech. Arts (E)
Professional
Subjects (P)
x
4.
Broad Area
Biotechnology
Bioprocess Engineering
Chemical
Engineering
x
--
--
5.
Approval
23rd Meeting of Academic Council, May 2013
129 Biotech-2013 SRM (E&T)
BT1027
BIOPROCESS ENGINEERING
L
T
P
C
Total No. of Contact Hours - 45
3
0
0
3
Prerequisite
BT1017
PURPOSE
This subject deals with the design, analysis monitoring , modeling and simulation
aspect of bioreactors
INSTRUCTIONAL OBJECTIVES
1.
To strengthen the knowledge on design, performance and stability of
bioreactors
2.
To understand the mass transfer process and bioreactor scale up
3.
To learn about the methods of on line and off line monitoring of bio process
4.
To acquire knowledge about the fundamentals of modeling and simulations
of bio process
UNIT I - DESIGN AND ANALYSIS OF BIOREACTORS (9 hours)
Introduction to ideal reactors: performance equations, Non-ideal reactors:
Tanks-in-series and Dispersion models-applications to design of continuous
sterilizers, Design and operation of novel bioreactors:Air-lift loop reactors;
Fluidized bed bioreactors, Stability analysis of bioreactors.
UNIT II - BIOREACTOR SCALE-UP (10 hours)
Transport phenomena in Bioprocess systems: Oxygen transfer in fermentation
broth, Rheological effects, Regime analysis of bioreactor processes,
Correlations for oxygen transfer; Scale-up: Criteria for bioreactors based on
oxygen transfer and power consumption.
UNIT III - MONITORING OF BIOPROCESSES (9 hours)
On-line data analysis for measurement of physico-chemical and biochemical
parameters: Methods of on-line and off-line biomass estimation; microbial
calorimetry, Flow injection analysis for measurement of substrates, products and
other metabolites; State and parameter estimation: Observer, Kalman filters,
ANN, Computer-based data acquisition: monitoring and control-LABVIEW
Software.
130 Biotech-2013 SRM (E&T)
UNIT IV - RECOMBINANT CELL CULTIVATION (8 hours)
Recombinant cell culture processes: Guidelines for choosing host-vector
systems, plasmid stability and instability model, limits to over expression,
Modeling of recombinant bacterial cultures; Bioreactor strategies for maximizing
product formation. Bioreactor configurations for cultivation of animal and plant
cells: Secondary metabolites from plant and animal cell cultures.
UNIT V - MODELLING AND SIMULATION OF BIOPROCESSES (9 hours)
Formulation of model: Study of Structured Models – Willam’s two compartment
model- Ramakrishna model- Metabolic model- Single cell model. Simulation
software packages: Model simulation using MATLAB, SIMULINK and ISIM,
Dynamic simulation studies: Batch, continuous and fed batch fermentation
process.
TEXT BOOKS
1. Shuler.M.L and Kargi. F, “Bioprocess Engineering : Basic Concepts” 2nd
Edition. Pearson, 2002.
2. Blanch.H.W and Clark.D.S. “Biochemical Engineering”. Marcal & Dekker,
Inc., 1997.
REFERENCES
1. Najaf pour.G.D, “Biochemical Engineering and Biotechnology”, Elsevier,
2007.
2. James M Lee. “Biochemical Engineering”, Prentice – Hall, 1992.
3. Bailey.J.E and Ollis.D.F, “Biochemical Engineering Fundamentals”, 2nd
Edition, McGraw-Hill, 1986.
4. Pauline.M.Doran, "Bioprocess Engineering Principles"; Academic press,
1995.
5. Alan.H.Scragg, "Bioreactors in Biotechnology- A Practical approach”, Ellis
Harwood, 1991.
6. Aiba.S, Humphrey.E and Milli.N.R, "Biochemical Engineering" Academic
Press, 1973.
131 Biotech-2013 SRM (E&T)
BT1027 BIOPROCESS ENGINEERING
Course Designed by
Department of Biotechnology
1.
Student outcomes
a
b
c
d
e
f
g
h
i
j
k
x
x
x
x
2.
Mapping of instructional
objectives with student
outcomes
1
2
4
3
3.
Category
General
Subjects (G)
Basic
Sciences (B)
Engg. Sci. &
Tech. Arts (E)
Professional
Subjects (P)
x
4.
Broad Area
Biotechnology
Bioprocess Engineering
Chemical
Engineering
--
x
--
5.
Approval
23rd Meeting of Academic Council, May 2013
BT1025
ANIMAL BIOTECHNOLOGY LABORATORY
L
T
P
C
Total No. of Contact Hours - 60
0
0
4
2
Prerequisite
BT1021
PURPOSE
Provides an opportunity to experimentally verify the theoretical concepts on
animal cell culture.
INSTRUCTIONAL OBJECTIVES
1.
To enable the students to understand the theoretical concepts in animal
biotechnology.
2.
To gain hands on experience on cell culture techniques
3.
To understand the significance of cultivation of the cells in vitro.
LIST OF EXPERIMENTS
1. Preparation of culture media and sterilization
2. Primary cell culture - Culture of chick embryo fibroblast cells
3. Culturing of spleen/liver cells
4. Passaging of cell lines
5. Maintenance of adherent and suspension cell cultures
6. Cryopreservation of cells
7. Cell revival
8. Live cell counting – Determining cell density of culture using
haemocytometer
9. Determining the differentiation of monolayer cells using fluorescence staining
technique.
10. Determining cell toxicity using MTT assay
132 Biotech-2013 SRM (E&T)
REFERENCES
1. Freshney.R.I, “Culture of Animal cells”, Fifth edition, Wiley Publishers, 2010.
2. Leach.C.K, “In vitro cultivation of Animal cells”, Butterworth and
Heinnmamm Ltd., 1994.
BT1025 ANIMAL BIOTECHNOLOGY LABORATORY
Course Designed by
Department of Biotechnology
1.
Student outcomes
a
b
c
d
e
f
g
h
i
J
k
x
x
2.
Mapping of instructional
objective with student
outcomes
2
2
3.
Category
General
Subjects (G)
Basic
Sciences (B)
Engg. Sci. &
Tech. Arts (E)
Professional
Subjects (P)
x
4.
Broad area
Biotechnology
Bioprocess
Engineering
Chemical
Engineering
x
--
--
5.
Approval
23rd Meeting of Academic Council, May 2013
BT1028
BIOPROCESS ENGINEERING LABORATORY
L
T
P
C
Total No. of Contact Hours - 30
0
0
2
1
Prerequisite
BT1027
PURPOSE
Provides an opportunity to experimentally verify the theoretical concepts studied in
Bioprocess Engineering. It also helps in understanding the theoretical principles in
a more explicit and concentrated manner.
INSTRUCTIONAL OBJECTIVE
1.
To enable the students to understand the basic concepts involved in the
bioprocess engineering such as sterilization kinetics, groeth kinetics and
effect of mass transfer in fermentation process.
LIST OF EXPERIMENTS
1. Sterilization kinetics- determination of holding time
2. Temperature effect on growth-estimation of energy of activation and
Arrhenius constant for microorganisms.
3. Growth kinetics of bacteria- evaluation of specific growth rate, yield
coefficient and doubling time
133 Biotech-2013 SRM (E&T)
4. Growth kinetics of yeast- evaluation of specific growth rate, yield coefficient
and doubling time
5. Screening of Medium composition – Plackett -Burman design
6. Estimation of Monod parameters
7. KLa determination by sulphite oxidation method
8. KLa determination by dynamic gassing method
9. Power correlation analysis
10. KLa determination by power correlation analysis
11. Study of rheology of fermentation broth
REFERENCE
1. Laboratory Manual
BT1028 BIOPROCESS ENGINEERING LABORATORY
Course Designed by
Department of Biotechnology Engineering
1.
Student outcomes
a
b
c
d
e
f
g
h
i
j
k
x
x
x
2.
Mapping of instructional
objective with Student
outcomes
1
1
1
3.
Category
General
(G)
Basic
Sciences (B)
Engg. Sci. &
Tech. Arts (E)
Professional
Subjects (P)
x
4.
Broad area
Biotechnology
Bioprocess
Engineering
Chemical
Engineering
--
--
x
--
--
5.
Approval
23rd Meeting of Academic Council, May 2013
BT1049
MINOR PROJECT
L
T
P
C
Total Contact Hours - 30
0
0
2
1
Prerequisite
Nil
PURPOSE
To carry out a design project in one of the specializations of the program with
substantial multidisciplinary component
INSTRUCTIONAL OBJECTIVES
1.
To guide the students in such a way so that they carry out a work on a topic
as a forerunner to the full fledged project work to be taken subsequently in VIII
semester. The project work shall consist of substantial multidisciplinary
component
134 Biotech-2013 SRM (E&T)
The students will carry out a project in one of the specializations of program under
study with substantial multidisciplinary component
Student groups will be formed and a faculty member will be allocated to guide
them. Assessment will be based on internal reviews. Based on the reviews marks
will be allotted out of 100.
BT1049 MINOR PROJECT
Course Designed by
Department of Biotechnology Engineering
1.
Student outcome
a
b
c
d
e
f
g
h
i
j
k
x
x
x
x
x
x
x
x
x
x
x
2.
Mapping of instructional
objectives with student
outcome
1
1
1
1
1
1
1
1
1
1
1
3.
Approval
23rd Meeting of Academic Council, May 2013
135 Biotech-2013 SRM (E&T)
SEMESTER - VII
BT1029
PROTEIN ENGINEERING AND PROTEOMICS
L
T
P
C
Total No. of Contact Hours – 45
3
0
0
3
Prerequisite
Nil
PURPOSE
The course aims at imparting knowledge on proteins through a detailed study of
protein structure, its characteristics property and significance in biological
systems with strategies for modifying the structures for desirable properties in
industry. It briefs about the different analytical techniques for elucidation of protein
structure.
INSTRUCTIONAL OBJECTIVES
1.
To appreciate the structure function correlation and the prediction of
properties of protein based on its sequence.
2.
To observe the similarities in structure at basal level in a group of having
similar function, thereby predicting the strategies to modify and design novel
proteins.
3.
To emphasize the role of analytical methods to determine protein structure
and protein – protein interactions
UNIT I - STRUCTURE FUNCTION DYNAMICS CORRELATION (9 hours)
Basic structural concepts – Primary, secondary, tertiary and quaternary
structures. Ramachandran plot, super secondary structures – motif and domain.
Protein folding and mechanisms.
UNIT II - STRUCTURE FUNCTION ENGINEERING (10 hours)
The correlation of structure and function in – transcription factors, serine
proteinases, membrane proteins, signal transduction proteins and recognition in
immune system.
UNIT III - PREDICTION AND DESIGN OF PROTEINS (10 hours)
Examples of designed proteins (enzymes) with enhanced stability and efficiency,
playing a significant role in industries. A case study for – introduction of disulfide
bonds (T4 lysozyme), reduction of free sulfhydryl groups, removal of metal
requirements in certain proteins, streptokinase, introduction of complementary
determining region in antibodies and to increase enzyme activity.
136 Biotech-2013 SRM (E&T)
UNIT IV - PROTEIN STRUCTURE CHARACTERIZATION (8 hours)
Proteomes, Analytical proteomics, Protein digestion and separation techniques.
Role of Mass spectrometry in protein identification – peptide mass fingerprinting,
Tandem MS and SALSA.
UNIT V - PROTEOMICS APPLICATION (8 hours)
Mining proteomes, protein expression profiling, identifying protein – protein
Interactions and protein complexes, mapping- protein identification, new
directions in proteomics.
TEXTBOOKS
1. Carl Brandon & John Tooze, “Introduction to Protein Structure,” “2nd Edition”
Garland Publishing, 1999
2. Daniel C. Liebler, “Introduction to Proteomics – Tools for the New Biology,”
Humana Press, 2001
REFERENCES
1. Paul R. Carey, “Protein Engineering and Design,” Academic Press, 1996.
2. Engelbert Buxbaum, “Fundamentals of Protein Structure and Function,”
Springer, 2007.
3. Amit Kessel & Nir Ben-Tal, “Introduction to Proteins: Structure, Function and
Motions,” CRC press, 2010.
4. Malcolm Campbell & Laurie J. Heyer, “Discovering Genomics, Proteomics &
Bioinformatics,” 2nd Edition by 2006.
BT1029 PROTEIN ENGINEERING AND PROTEOMICS
Course Designed by
Department of Biotechnology
1.
Student outcomes
a
b
c
d
e
f
g
h
i
j
k
x
x
x
x
2.
Mapping of instructional
objectives with student
outcomes
1
2
3
3
3.
Category
General(G)
Basic
Sciences (B)
Engg. Sci. &
Tech. Arts (E)
Professional
Subjects (P)
x
4.
Broad Area
Biotechnology
Bioprocess
Engineering
Chemical
Engineering
x
--
--
5.
Approval
23rd Meeting of Academic Council, May 2013
137 Biotech-2013 SRM (E&T)
BT1030
BIOSEPARATION TECHNOLOGY
L
T
P
C
Total No. of Contact Hours - 45
3
0
0
3
Prerequisite
BT1027
PURPOSE
The course provides an opportunity to understand the importance of the
Bioseparation process, economics and process design of bioproducts.
INSTRUCTIONAL OBJECTIVES
1.
To understand the importance of bioseparation processes and solid- liquid
separation processes
2.
To gain knowledge about isolation of desired product and purification
strategies
3.
To learn about the unit operations involved in product finishing process
UNIT I - INTRODUCTION TO BIOSEPARATION PROCESS (9 hours)
Role and importance of bioseparation in biotechnological processes: RIPP
scheme, Problems and requirements of bioproducts purification - Properties of
Biomolecules - Characteristics of fermentation broth - Biological activity, Analysis
of purity-Process economics: Capital and operating cost analysis.
UNIT II - REMOVAL OF INSOUBLES (9 hours)
Cell disruption methods for intracellular products: Physical, chemical and
mechanical - Removal of insolubles: Biomass and particulate debris separation
techniques - flocculation - sedimentation - centrifugation and filtration methods.
UNIT III - ISOLATION OF PRODUCTS (9 hours)
Adsorption: Principles - Langumir- Freundlich isotherms - Extraction:Basics-
Batch and continuous, aqueous two-phase extraction - supercritical extraction -
in situ product removal - Precipitation: Methods of precipitation with salts -
organic solvents and polymers - Membrane based separations: Micro and ultra
filtration - theory - design and configuration of membrane separation equipment -
applications.
UNIT IV - PURIFICATION OF BIOPRODUCT (9 hours)
Basic principles of Chromatographic separations: GC - HPLC - gel permeation -
ion-exchange - affinity - reverse phase and hydrophobic interaction
chromatography - Electrophoretic separation techniques: capillary - isoelectric
focusing - 2D gel electrophoresis - Hybrid separation technologies: GC-MS and
LC-MS.
138 Biotech-2013 SRM (E&T)
UNIT V - PRODUCT POLISHING (9 hours)
Crystallization: Principles-Nucleation-Crystal growth-Kinetics-Batch
crystallizers: Scale-up and design, Drying: Principles-Water in biological solids-
Heat and mass transfer-Drying equipments: description and operation-Vacuum
shelf - rotary dryer-Freeze dryer-Spray dryer.
TEXT BOOKS
1. Roger G. Harrison, Paul Todd, Scott R. Rudge, Demetri P. Petrides, "Bio
separation Science and Engineering" Oxford University press, 2003.
2. Belter PA and Cussler E, "Bioseparations", Wiley, 1985.
REFERENCES
1. Raja Ghosh, “Principles of Bioseparations Engineering”,World Scientific
Publishing, 2006.
2. Ladisch.M.R, "Bioseparation Engineering: Principles, Practice and
Economics", John Wiley & sons, New York, 2001.
3. Asenjo.J.M, "Separation processes in Biotechnology" Marcel Dekker
Inc.1993.
BT1030 BIOSEPARATION TECHNOLOGY
Course Designed by
Department of Biotechnology
1.
Student outcomes
a
b
c
d
e
f
g
h
i
j
k
x
x
x
2.
Mapping of instructional
objectives with student
outcomes
2
1
3
3.
Category
General(G)
Basic
Sciences (B)
Engg. Sci. &
Tech. Arts E)
Professional
Subjects (P)
x
4.
Broad Area
Biotechnology
Bioprocess
Engineering
Chemical
Engineering
--
--
x
x
--
5.
Approval
23rd Meeting of Academic Council, May 2013
139 Biotech-2013 SRM (E&T)
BT1032
ETHICAL ISSUES, RESEARCH METHODOLOGY
AND INTELLECTUAL PROPERTY RIGHTS
L
T
P
C
Total No. of Contact Hours - 15
1
0
0
1
Prerequisite
Nil
PURPOSE
The course is designed to outline the methodology for research in biotechnology
and provides an understanding of the ethical issues underlying biotechnology
research and innovation in addition to protection of the acquired intellectual
property. The student will gain an understanding research methodology, the
ethical issues underlying biotechnology research and the importance of protection
of intellectual property.
INSTRUCTIONAL OBJECTIVES
1.
To caution the nature of hazards related to biotechnology and the
importance of biosafety in research.
2.
To debate on ethical issues related to biotechnology research.
3.
To give an overview of the methods used in scientific research and to
emphasize on the importance of statistical concepts.
4.
To provides guidelines on accessing scientific literature, and preparing
scientific papers and presentation.
5.
To impart knowledge on the importance of intellectual property and its
protection under the constitution.
UNIT I - BIOSAFETY AND GMOs IN INDIA (6 hours)
Regulatory framework in India governing GMOs-Recombinant DNA Advisory
Committee (RDAC) - Institutional Biosafety Committee (IBSC) - Review
Committee on Genetic Manipulation, Genetic Engineering Approval Committee
(GEAC) - State Biosafety Coordination Committee (SBCC) - District Level
Committee (DLC). Recombinant DNA Guidelines (1990) -Revised Guidelines for
Research in Transgenic Plants (1998) - Prevention Food Adulteration Act (1986)
- The Food Safety and Standards Bill (2005)
UNIT II - BIOSAFETY-REGULATORY FRAMEWORK FOR GMOS (6 hours)
Rules for the manufacture, use/import/export and storage of hazardous
microorganisms/genetically engineered organisms or cells (Ministry of
Environment and Forests Notification (1989) - Plant Quarantine Order (2003),
Regulation for Import of GM Products Under Foreign Trade Policy (2006-2007)
National Environment Policy (2006) - Convention of Biological Diversity (1992) -
140 Biotech-2013 SRM (E&T)
Cartagena Protocol on Biosafety - Objectives and salient features of Cartagena
Protocol - Advanced Information Agreement (AIA) procedure - procedures for
GMOs intended for direct use-risk assessment- risk management-handling,
transport, packaging and identification of GMOs - Biosafety Clearing House-
unintentional transboundary movement of GMOs
UNIT III - BIOETHICS (6 hours)
The legal and socioeconomic impacts of biotechnology-Public education of the
process of biotechnology involved in generating new forms of life for informed
decision making ethical concerns of biotechnology research and innovation.
UNIT IV - RESEARCH METHODOLOGY (6 hours)
Introduction to the design, analysis, and presentation of scientific projects -
methods used in scientific research - hypothesis testing - the measurement of
functional relationships - and observational research-important features of
experimental design,- control of errors- instrument calibration - data analysis
UNIT V - INTELLECTUAL PROPERTY RIGHTS (6 hours)
Intellectual property rights - patents and methods of application of patents - legal
implications- objectives of the patent system - basic principles and general
requirements of patent law-biotechnological inventions and patent law -
patentable subjects and protection in biotechnology- TRIPs – GATT -
Biodiversity and Plant variety protection and farmer rights - Seed Policy (2002)
TEXT BOOKS
1. Sasson.A , “Biotechnologies and Development”, UNESCO Publications.
2. Singh.K, “Intellectual Property rights in Biotechnology”, , BCIL, New Delhi.
3. “Regulatory Framework for GMOs in India” Ministry of Environment and
Forest, Government of India,New Delhi, (2006).
4. “Cartagena Protocol on Biosafety” Ministry of Environment and Forest,
Government of India, New Delhi, (2006).
5. Michael P. Marder “Research methods for Science” Cambridge University
Press.
141 Biotech-2013 SRM (E&T)
BT1032 ETHICAL ISSUES, RESEARCH METHODOLOGY AND INTELLECTUAL PROPERTY
RIGHTS
Course Designed by
Department of Biotechnology
1.
Student outcomes
a
b
c
d
e
f
g
h
i
j
k
x
x
x
x
x
x
2.
Mapping of instructional
objectives with student
outcomes
1-5
1-5
1-5
1-5
1-5
1-5
3.
Category
General
Subjects(G)
Basic
Sciences(B)
Engg. Sci. &
Tech. Arts (E)
Professional
Subjects (P)
x
4.
Broad Area
Biotechnology
Bioproc.Engg.
Chemical Engineering
x
5.
Approval
23rd Meeting of Academic Council, May 2013
BT1031
BIOSEPARATION TECHNOLOGY LABORATORY
L
T
P
C
Total No. of Contact Hours - 30
0
0
2
1
Prerequisite
BT1030
PURPOSE
Provides an opportunity to experimentally check the theoretical concepts related
to Bioseparation Technology. It also helps in understanding the theoretical
principles
INSTRUCTIONAL OBJECTIVE
1.
The students will be exposed to various Bioseparation process such as cell
disruption, Product isolation and purification methods
LIST OF EXPERIMENTS
1. Mechanical cell disruption – Ultrasonication
2. Mechanical cell disruption – High pressure homogeneizer
3. Enzymatic cell disruption by lysozyme
4. Separation of insolubles by batch sedimentation- determination of thickener
area
5. Flocculation
6. Separation of insolubles by filtration –determination of specific cake
resistance
7. Aqueous two phase extraction
8. Ammonium sulphate precipitation and dialysis
9. Ultra and microfiltration
10. Gas chromatography
11. Lyophilization
142 Biotech-2013 SRM (E&T)
REFERENCE
1. Scopes AK, "Protein Purification", IRL Press, 1993.
BT1031 BIOSEPARATION TECHNOLOGY LABORATORY
Course Designed by
Department of Biotechnology
1.
Student outcomes
a
b
c
d
e
f
g
h
i
j
k
x
x
x
2.
Mapping of instructional
objective with student
outcomes
1
1
1
3.
Category
General(G)
Basic
Sciences (B)
Engg. Sci. &
Tech. Arts (E)
Professional
Subjects(P)
x
4.
Broad area
Biotechnology
Bioprocess Engineering
Chemical
Engineering
--
x
x
5.
Approval
23rd Meeting of Academic Council, May 2013
BT1048
INDUSTRIAL TRAINING II
(Training to be undergone after VI semester)
L
T
P
C
2 weeks practical training in industry
0
0
1
1
Prerequisite
Nil
PURPOSE
To provide hands-on experience by working in biotechnology related industries
INSTRUCTIONAL OBJECTIVES
1.
Students have to undergo practical training in bioengineering industries or
training institutes so that they become aware of the practical application of
theoretical concepts studied in the class rooms
Students have to undergo two-week practical training in biotechnology related
project of their choice but with the approval of the department. At the end of the
training student will submit a report as per the prescribed format to the
department.
Assessment process
This course is mandatory and the student has to pass the course to become
eligible for the award of degree. The student shall make a presentation before a
committee constituted by the department which will assess the student based on
the report submitted and the presentation made. Marks will be awarded out of 100
and appropriate grades assigned as per the regulations.
143 Biotech-2013 SRM (E&T)
BT1048 INDUSTRIAL TRAINING II
Course Designed by
Department of Biotechnology
1.
Student outcome
a
b
c
d
e
f
g
h
i
j
k
x
x
x
x
x
x
2.
Mapping of instructional
objective with student
outcome
1
1
1
1
1
1
3.
Category
General
Subjects (G)
Basic
Sciences (B)
Engg. Sci. &
Tech. Arts (E)
Professional
Subjects (P)
x
4.
Broad area
Biotechnology
Bioprocess Engineering
Chemical
Engineering
x
--
5.
Approval
23rd Meeting of Academic Council, May 2013
144 Biotech-2013 SRM (E&T)
SEMESTER - VIII
BT1050
MAJOR PROJECT / PRACTICE SCHOOL
L
T
P
C
Total Contact Hours - 360
0
0
24
12
Prerequisite
Nil
PURPOSE
To simulate real life situations related to the program and impart adequate training
so that confidence to face and tackle any problem in the field is developed in the
college itself.
INSTRUCTIONAL OBJECTIVES
1.
To guide the students such a way that the they carry out a comprehensive
work on the chosen topic which will stand them in good stead as they face
real life situations. The project work so chosen by the student shall culminate
in gaining of major design experience in the related area of specialization.
MAJOR PROJECT
Each project will cover all the aspects (to the extent possible) of real life
application of concepts studied under the program. . Alternately, a few research
problems also may be identified for investigation. The project shall be driven by
realistic constraints like that related to economic, environmental, social, political,
ethical, health & safety, manufacturability and sustainability. The outcomes to be
attained by students by doing the project work shall be spelt out clearly. A project
report is to be submitted on the topic which will be evaluated during the final
review. Assessment procedure will be as spelt out in the regulations.
PRACTICE SCHOOL
Alternately, a student is encouraged to take an industrial project with reputed
organizations or firms chosen by the institute. In such cases the student will stay
with the firm and carry out the project. The project will be guided by the faculty
member and the concerned officer in the industry. All the requirements spelt out
under ‘MAJOR PROJECT’ above, shall be incorporated under this work also.
However reviews will be conducted in the institute which the student shall attend.
BT1050 MAJOR PROJECT
Course Designed by
Department of Biotechnology Engineering
1.
Student outcome
a
b
c
d
e
f
g
h
i
j
k
x
x
x
x
x
x
x
x
x
x
x
2.
Mapping of instructional
objectives with student
outcome
1
1
1
1
1
1
1
1
1
1
1
3.
Approval
23rd Meeting of Academic Council, May 2013
145 Biotech-2013 SRM (E&T)
DEPARTMENT ELECTIVES
BT1051
CANCER BIOLOGY
L
T
P
C
Total No. of Contact Hours - 45
3
0
0
3
Prerequisite
Cell biology, Biochemistry and Immunology
PURPOSE
To provide knowledge about biological aspects of cancer.
INSTRUCTIONAL OBJECTIVE
1.
To impart basic concepts of cancer biology, various stages in
carcinogenesis, molecular cell biology of cancer, cancer metastasis, and
cancer therapy.
UNIT I - CANCER CELL BIOLOGY (8 hours)
Introduction to Cancer --Cell cycle—pRb--Tumor suppressor genes--Knudson’s
two-hit hypothesis--p53--Myc oncoprotein--TGF-b --Cell cycle and cancer--
Different forms of cancer--Diet and Cancer
UNIT II - CARCINOGENESIS (8 hours)
Stages of Carcinogenesis-Environment, Genetics, and Cancer—Causes of
cancer—Classes and Types of Carcinogens—Ecogenetics and Cancer risk—
Carcinogen Metabolism—Epigenetics--DNA repair, pathways, and Human Cancer
UNIT III - SIGNAL TRANSDUCTION: CELL DIVISION, DIFFERENTIATION, AND
APOPTOSIS (12 hours)
Signal Transduction-Growth factor signaling-EGF signaling-Oncogenes—Wnt
signaling--Immune system in cancer—B cell, T cell, and Cytokine signaling—
Neuroendcrine system in cancer-Hormone and Neurotransmitter signaling—
Apoptosis—Cancer stem cells
UNIT IV - METASTASIS AND ANGIOGENESIS (9 hours)
Tumor microenvironment in cancer progression—Invasion and Metastasis-Stages
in metastasis and the factors involved in the invasive process—Angiogenesis-
VEGF signaling
UNIT V - CANCER THERAPY, PREVENTION AND DIAGNOSIS (8 hours)
Current modalities of treatment-Radiation therapy-Surgery-Chemotherapy-
Classification of properties of chemotherpeutic drugs—Biological therapy-Cancer
prevention and early detection -Imaging and cancer
146 Biotech-2013 SRM (E&T)
TEXT BOOK
1. Robert A. Weinberg, “The Biology of Cancer,” Garland Science; 1 Cdr edition,
2010.
REFERENCE
1. Lauren Pecorino, “Molecular Biology of cancer: Mechanisms, Targets, and
Terapeutics,” Oxford University Press. 3rd edition, 2012.
BT1051 CANCER BIOLOGY
Course Designed by
Department of Biotechnology
1.
Student outcomes
a
b
c
d
e
f
g
h
i
j
k
x
x
x
x
x
x
2.
Mapping of instructional
objectives with student
outcomes
1
1
1
3.
Category
General(G)
Basic
Sciences (B)
Engg. Sci. &
Tech. Arts (E)
Professional
Subjects (P)
x
4.
Broad Area
Biotechnology
Bioprocess
Engineering
Chemical
Engineering
x
--
--
5.
Approval
23rd Meeting of Academic Council, May 2013
BT1052
STEM CELL BIOLOGY
L
T
P
C
Total No. of Contact Hours - 45
3
0
0
3
Prerequisite
BT1003,BT1004
PURPOSE
The course aims at imparting basic and advanced topics in Stem Cell Biology and
its clinical applications.
INSTRUCTIONAL OBJECTIVES
1.
To strengthen the knowledge of students on stem cell basics and their
applications for the benefit of mankind.
2.
To impart knowledge about stem cell culturing and stem cell signaling.
147 Biotech-2013 SRM (E&T)
UNIT I - INTRODUCTION TO STEM CELLS (8 hours)
Stem Cells sources -Unique properties of stem cells- classification- Embryonic
stem cells-adult stem cells-umbilical cord stem cells-similarities and differences
between adult and embryonic stem cells.
UNIT II - EMBRYONIC STEM CELLS (10 hours)
Stem cells and their developmental potential. In vitro fertilization-culturing of
embryos-blastocyst-inner cell mass-isolation and growing ES cells in lab-
Identification and characterization of human ES cells-Cloning and controlled
differentiation of human embryonic stem cells. Applications of Embryonic stem
cells.
UNIT III - ADULT STEM CELLS (9 hours)
Somatic stem cells-test for identification of adult stem cells- adult stem cell
differentiation-trans differentiation-plasticity-different types of adult stem cells-
liver stem cells-skeletal muscle stem cells-bone marrow derived stem cells.
UNIT IV - STEM CELLS IN TISSUE ENGINEERING (10 hours)
Haematopoietic Stem Cells-Growth factors and the regulation of haematopoietic
stem cells-clinical applications of haematopoietic stem cells.Mesenchymal stem
cells and their role in bone tissue engineering-bone repair.Therapeutic
applications-Parkinsons disease-diabetes. Stem cell based gene therapy and
benefits to human.
UNIT V - STEM CELL SIGNALING (8 hours)
Tumor stem cells-common signaling pathways in cancer and embryonic stem
cells-Notch signaling- pathway-wnt signaling in cancer and stem cell self renewal.
TEXTBOOKS
1. Potten.C S, “Stem Cells,” Elsevier, 1996.
2. Robert Lanza, “Essentials of Stem Cell Biology,” Academic Press, 2009.
REFERENCES
1. Ariff Bongso, Eng Hin Lee, “Stem Cells: From Bench to Bedside,” World
Scientific, 2011.
2. Daniel R. Marshak, “Stem cell biology,” Cold Spring Harbor Laboratory
Press, 2001.
3. Peter Quesenberry, “Stem cell biology and Gene Therapy,” Wiley-Liss, 1998.
148 Biotech-2013 SRM (E&T)
BT1052 STEM CELL BIOLOGY
Course Designed by
Department of Biotechnology
1.
Student outcomes
a
b
c
d
e
f
g
h
i
j
k
x
x
x
x
x
x
2.
Mapping of instructional
objectives with student
outcomes
1
2
2
1
2
1
3.
Category
General(G)
Basic
Sciences (B)
Engg. Sci. &
Tech. Arts (E)
Professional
Subjects (P)
x
4.
Broad Area
Biotechnology
Bioprocess
Engineering
Chemical engineering
x
--
--
5.
Approval
23rd Meeting of Academic Council, May 2013
BT1053
DRUG AND PHARMACEUTICAL
BIOTECHNOLOGY
L
T
P
C
Total No. of Contact Hours – 45
3
0
0
3
Prerequisite
Nil
PURPOSE
The course design is aimed at industrial production of various biopharmaceuticals
for various disorders. The student also gains the fundamental science behind the
manufacturing procedure of the drugs and vaccines, as well as, the Patho-
physiology in humans.
INSTRUCTIONAL OBJECTIVES
1.
To understand the various dosage forms and the choice of dosage form
based on the need.
2.
To gain in depth knowledge on normal physiology of nervous system and the
effects of biopharmaceuticals on the system.
3.
To signify the role of biomaterials and biotechnological products in cardio
vascular disorders.
4.
To impart the knowledge on industrial scale production of several important
pharmaceutical products by biocatalytic routes.
5.
To highlight the current and futuristic trends in vaccine technology and its
importance in health care.
UNIT I - DRUG DELIVERY SYSTEM (7 hours)
Various dosage forms, advantages and disadvantages. Controlled and Sustained
drug delivery mechanism and the role of biopolymers. Futuristic perspective on
149 Biotech-2013 SRM (E&T)
bio - watches for serological analysis, titration of dose and release of the
medication.
UNIT II - DRUGS ACTING ON NERVOUS SYSTEM (10 hours)
Molecular mechanism of neuro-transmission – Action potential, Threshold
potential, RMP, EPSP and IPSP.Various neurotransmitter and cross-talk.Effects of
agonist and antagonist in adrenergic and cholinergic receptors.
UNIT III - BIOTECHNOLOGY IN CARDIO VASCULAR DISORDERS (10 hours)
Introduction to CVS disorders – pulmonary thrombo-embolism, valvular disorders,
heart bloc, ischemia and myocardial infarction. Biopolymers – stents, artificial
blood vessels and valves. Pace maker and artificial heart - lung machine. Rennin -
angiotensin mechanism for blood pressure regulation. Dialyzer.
UNIT IV - BIOCATALYSIS (10 hours)
Prostaglandin synthesis, biocatalytic routes for the synthesis of – anti-
inflammatory drugs, anticholesterol drugs, calcium channel blockers, potassium
channel openers and anti-arrhythmic agents.Chiral compound (teratogenecity)
synthesis (ACE inhibitors) with help of biocatalysis.
UNIT V - VACCINE TECHNOLOGY (8 hours)
Conventional vaccines, antiidiotype vaccine, naked DNA vaccine and ISCOM’s.
Vaccines against Hepatitis A, Malaria,Typhoid and HIV (in clinical trials).
TEXTBOOKS
1. Tripathi.K.D, “Essentials of Medical Pharmacology,” 6th Edition, Jaypee
publications, 2008.
2. Crommelin.D.J.A, Robert D. Sindela, “Pharmaceutical Biotechnology,” 2nd
Edition - 2004.
3. Remington,”The science and Practice of Pharmacy,” by Vol. I and II, 20th
Edition, 2007.
REFERENCES
1. “Medicinal chemistry: A molecular and biochemical approach,” 3rd Edition,
OUP, 2005.
2. Gary Walsh, “Pharmaceutical Biotechnology-Concepts and Applications,”
Wiley, 2007.
3. Stanbury.P.F, Whitaker.A and Hall.S.J, “Principles of Fermentation
Technology”, 2nd Edition, Aditya Books (P) Ltd, 1995.
4. Hugo.W.B and Russel.A.D, “Pharmaceutical Microbiology”, 6th Edition,
Blackwell Science, 2003.
150 Biotech-2013 SRM (E&T)
BT1053 DRUG AND PHARMACEUTICAL BIOTECHNOLOGY
Course Designed by
Department of Biotechnology
1.
Student outcomes
a
b
c
d
e
f
g
h
i
j
k
x
x
x
2.
Mapping of instructional
objectives with student
outcomes
1
4
5
3.
Category
General(G)
Basic
Sciences (B)
Engg. Sci. &
Tech. Arts (E)
Professional
Subjects (P)
x
4.
Broad Area
Biotechnology
Bioprocess
Engineering
Chemical
engineering
x
--
--
5.
Approval
23rd Meeting of Academic Council, May 2013
BT1054
COMPUTER SIMULATION AND DRUG
DESIGNING
L
T
P
C
Total No. of Contact Hours – 45
3
0
0
3
Prerequisite
Nil
PURPOSE
The course is aimed at elaborating on the fundamental concepts of classical
mechanics and quantum mechanics, thereby highlighting the role of computers in
theoretical chemistry calculations. The student would also acquire brief
knowledge on parameters considered for drug designing and the computational
role in preclinical studies.
INSTRUCTIONAL OBJECTIVES
1.
To understand the black box calculation of parameters of biomolecules and
its behavior.
2.
To highlight the different approaches for drug designing and the computer
softwares used for it.
3.
To impart the knowledge on artificial intelligence in preclinical trials.
UNIT I - COMPUTER SIMULATION (10 hours)
Useful Concepts in Molecular Modeling: Coordinate Systems. Potential Energy
Surfaces.Molecular Graphics.Surfaces.Computer Hardware and Software.Force
Fields.Bond Stretching.Angle Bending.Introduction to Non-bonded
Interactions.Electrostatic Interactions.Van der Waals Interactions.Hydrogen
Bonding in Molecular Mechanics.Minimisation and Related Methods for Exploring
the Energy Surface. Non-Derivative method, 1st and 2nd order minimisation
methods. Computer Simulation Methods.
151 Biotech-2013 SRM (E&T)
UNIT II - MODELING METHODS (10 hours)
Computer Simulation Methods.Simple Thermodynamic Properties and Phase
Space.Boundaries. Free energies and solvation, electrostatic and non electrostatic
contribution to free energies. Simulation analysis and Error Estimation.MO
Theory.Empirical Methods.Geometric Optimization (Gaussian).Free Energy
Perturbation.Global minimum problem.Simulated Annealing.Monte Carlo
Simulation.
UNIT III - ANALOGUE BASED DRUG DESIGN (8 hours)
Quantitative Structure Activity Relationship and parameters considered. Hit and
target – lead discovery strategies, multi target drugs, lead molecule identification
and optimization, design of bioassay, optimizing target interactions, Combinatorial
and parallel synthesis. Molecular modeling in drug discovery.
UNIT IV - STRUCTURE BASED DRUG DESIGN (10 hours)
Introduction to HIV protease inhibitor design strategy, 3D pharmacophores,
molecular docking, De novo Ligand design, 3D data base and virtual screening,
sources of data, molecular similarity and similarity searching. Rational drug
design – reduction of toxicity, endogenous compounds as drugs.Preclinical and
clinical trials.
UNIT V – ARTIFICIAL INTELLIGENCE IN DRUG DESIGN (7 hours)
The Castlemaine Project.Role of AI techniques in Castlemaine project.
Computational tools for drug design. Expert Systems.Computer Languages for AI
applications. Multivariate QSAR – role of AI.
TEXTBOOKS
1. Andrew Leach, “Molecular Modeling: Principles and applications,” 2nd
edition, Pearson Education.
2. Pandeya.S.N, “An Introduction to Drug Design,” NewAge International (P)
Ltd., Publishers, ISBN : 978-81-224-0943-7.
REFERENCES
1. Vinter.J.G, Mark Gardner, “Molecular Modelling and Drug Design,” CRC
presss, ISBN-13:978-0849377723
2. Graham L. Patrick, “An Introduction to Medicinal Chemistry”
3. Remington, “The science and Practice of Pharmacy,” Vol. I and II, 20th
Edition, 2007.
4. “Medicinal chemistry: A molecular and biochemical approach,” 3rd Edition,
OUP, 2005.
152 Biotech-2013 SRM (E&T)
BT1054 COMPUTER SIMULATION AND DRUG DESIGNING
Course Designed by
Department of Biotechnology
1.
Student outcomes
a
b
c
d
e
f
g
h
i
j
k
x
x
x
x
2.
Mapping of instructional
objectives with student
outcomes
1
2
3
3
3.
Category
General
(G)
Basic
Sciences (B)
Engg. Sci. &
Tech. Arts (E)
Professional
Subjects (P)
x
4.
Broad Area
Biotechnology
Bioprocess
Engineering
Chemical
Engineering
x
--
--
5.
Approval
23rd Meeting of Academic Council, May 2013
BT1055
INDUSTRIAL FERMENTATION TECHNOLOGY
L
T
P
C
Total No. of Contact Hours - 45
3
0
0
3
Prerequisite
Nil
PURPOSE
This course provides an opportunity to learn the importance of the industrial
fermentation processes and production of various valuable bioproducts through
fermentation.
INSTRUCTIONAL OBJECTIVES
1.
To understand the basics of industrial fermentation process.
2.
To gain the knowledge about the products of primary and secondary
microbial metabolites
3.
To learn about the production process of beverages and pharmaceutically
important bioproducts.
UNIT I - BASICS OF INDUSTRIAL FERMENTATI (6 hours)
Introduction to industrial fermentations: Types of fermentation process –
Microbial growth metabolism: Microbial metabolites – screening – strain
development, preservation methods – Product development: regulation and
safety -use of Process flowcharts and block diagrams.
UNIT II - PRODUCTION OF PRIMARY METABOLITES (10 hours)
Production of primary metabolites:Organic acids fermentation:Citric acid –
Acetic acid – Lactic acid – Amino acids:L-glutamic acid – L-lysine – L-
tryptophan – Solvents:Acetone-Butanol – Ethanol.
153 Biotech-2013 SRM (E&T)
UNIT III - PRODUCTION OF SECONDARY METABOLITES (10hours)
Antibiotic production: Classification-Carbohydrate containing
antibiotic:Streptomycin – Macro cyclic lactones: Erythromycin – Quiones:
Tetracycline – Amino acid containing antibiotic:Penicillin – Peptide antibiotic:
Bacitracin – Industrial Enzyme production:α-amylase – cellulase – protease –
lipase, Vitamins: Cyanaocobalamin – Riboflavin Fermentation.
UNIT IV - FOOD AND BEVERAGE FERMENTATION (10 hours)
Food fermentations: Cheese – yogurt – sauerkraut – soy sauce- Food flavoring
agents: MSG – γ-decalactone – Food preservative: Nisin – Food
colorants:Monascus pigments fermentation – Production of single cell protein:
Bel – symba – pekilo – pruteen processes - Beverages: Brewing process – Wine
and Cider production.
UNIT V - PRODUCTION OF OTHER COMMERCIAL PRODUCT (9 hours)
Recombinant protein production: Insulin – interferon – Production of
nucleosides and nucleotides: 5’ IMP – 5’ GMP – Enzyme biotransformations:
Types- steriod – antibiotic transformations-Biopolymers: Xanthan gum – PHA –
PHB – Agrochemicals: Bacillus thuringenesis insecticide production.
TEXT BOOK
1. Wulf Cruger and Anneleise Cruger, “Biotechnology: A Textbook of Industrial
Microbiology”, Panima Publishing ,2000
REFERENCES
1. Yuan Kun Lee, “Microbial Biotechnology: Principles and Applications”, World
Scientific Publishing 2006.
2. Michael J. Waites, “Industrial Microbiology: An Introduction”, Blackwell
Science, 2001.
3. Samuel Cate Prescott, Cecil Gordon Dunn, Gerald Reed, “Prescott & Dunn's
Industrial Microbiology”, CBS Publishers, 1983.
4. Patel.A.H, “Industrial Microbiology”, MacMillan Publishers, 1985.
5. Ratledge, Colin and Bjorn Kristiansen “Basic Biotechnology” 2nd EdN,
Cambridge University Press, 2001.
6. Henry J. Peppler, D. Perlman, “Microbial Technology: Microbial processes”,
Volume I, Academic Press, 1979.
7. L.E.Casida JR, “Industrial Microbiology”, New Age international Publishing,
1968.
154 Biotech-2013 SRM (E&T)
BT1055 INDUSTRIAL FERMENTATION TECHNOLOGY
Course Designed by
Department of Biotechnology
1.
Student outcomes
a
b
c
d
e
f
g
h
i
j
k
x
x
x
2.
Mapping of instructional
objectives with student
outcomes
2
1
3
3.
Category
General(G)
Basic
Sciences(B)
Engg. Sci. &
Tech. Arts (E)
Professional
Subjects (P)
x
4.
Broad Area
Biotechnology
Bioprocess Engineering
Chemical
Engineering
--
x
x
5.
Approval
23rd Meeting of Academic Council, May 2013
BT1056
BIOREACTOR DESIGN
L
T
P
C
Total No. of Contact Hours - 45
3
0
0
3
Prerequisite
BT1027
PURPOSE
The course imparts advanced knowledge on bioreactor design for efficient
utilization of the principles in bioprocess technology.
INSTRUCTIONAL OBJECTIVES
1.
To understand the basic concepts of bioreactor design
2.
To learn about the Air-driven bioreactors and bioreactors for plant and
animal cell cultivation
3.
To study about the solid state bioreactors and instrumentation control of
bioreactors
UNIT I - BIOREACTOR DESIGN (9 hours)
Types of Bioreactor: Stirred tank bioreactors – Design equations: Batch – CSTR
– Fed Batch reactor, Monod model for a chemostat – Multistage fermenter.
UNIT II - AIR-DRIVEN BIOREACTORS (9 hours)
Airlift bioreactors: Design and construction of the airlift - loop reactor,
Hydrodynamics – Three - phase flow – Mixing – Oxygen transfer, Design and
construction of Bubble column fermenter: Design and operation of Fluidized bed
bioreactor.
155 Biotech-2013 SRM (E&T)
UNIT III - PLANT AND ANIMAL CELL BIOREACTORS (9 hours)
Design consideration for plant cell cultivation: Plant cell bioreactors- STR –
ALR – BC – rotary drum – spin filter – process strategies – Animal cell
bioreactors: Bubble Columns and Air-Lift Reactors – Fluidized Bed Bioreactors –
Membrane Bioreactor Design: Cell Recycle Membrane Reactors.
UNITIV - SOLID STATE FERMENTATION BIOREACTORS (9hours)
Solid-State Bioreactor Fundamentals: Selection and design of SSF reactors –
Heat and mass transfer in SSF reactors – Types:Unaerated and Unmixed,
Forcefully-Aerated Bioreactors Without Mixing, Rotating-Drum and Stirred-Drum
Bioreactors – Continuously-Mixed, Forcefully-Aerated Bioreactors –
Intermittently-Mixed Forcefully-Aerated Bioreactors.
UNIT V - INSTRUMENTATION CONTROL OF BIOREACTORS (9 hours)
Bioreactor sensor characteristics: Temperature measurement control –
principles of dissolved oxygen measurement and control – principles of pH /
redox measurement and control – deduction and prevention of foam –
Determination of biomass and application of biosensors,Off –gas analysis:
Steady - state balancing – Derived quantities based on combined gas analysis
and gas mass balancing techniques – Gas analyzers.
TEXT BOOKS
1. Scragg H., "Bioreactors in Biotechnology", Ellis Horwood series, 1991.
2. Klaas Van't Riet, Johannes Tramper, "Basic Bioreactor Design", 2nd ed.,
Marcel Dekker, Inc., New York, 1991
REFERENCES
1. Henry C. Vogel, “Fermentation and biochemical engineering handbook:
principles,process design, and equipment”, Noyes Publications, 1983.
2. David Mitchell, Nadia Krieger, Marin Berovic, “Solid-State Fermentation
Bioreactors :Fundamentals of Design and Operation”, Springer-Verlag Berlin
Heidelberg ,2006.
3. Regine Eibl, Dieter Eibl, Ralf Pörtner, “Cell and Tissue Reaction Engineering:
Principles and Practice”, Springer,2008.
4. Saurabh Chattopadhyay, Sunita Farkya, Ashok K. Srivastava, and Virendra S.
Bisaria “Bioprocess Considerations for Production of Secondary Metabolites
by Plant Cell Suspension Cultures”, Biotechnology and Bioprocess
Engineering”. 2002, 7: 138-149.
156 Biotech-2013 SRM (E&T)
BT1056 BIOREACTOR DESIGN
Course Designed by
Department of Biotechnology
1.
Student outcomes
a
b
c
d
e
f
g
h
i
j
k
x
x
x
2.
Mapping of instructional
objectives with student
outcomes
2
1
3
3.
Category
General(G)
Basic
Sciences (B)
Engg. Sci. &
Tech. Arts (E)
Professional
Subjects(P)
x
4.
Broad Area
Biotechnology
Bioprocess
Engineering
Chemical Engineering
--
x
x
5.
Approval
23rdMeeting of Academic Council, May 2013
BT1057
FOOD AND BEVERAGE FERMENTATION
TECHNOLOGY
L
T
P
C
Total No. of Contact Hours - 45
3
0
0
3
Prerequisite
Nil
PURPOSE
To make the student to understand the science underpinning food fermentations,
food preservation , technology of fermented beverages and fermented food
products and food sanitation.
INSTRUCTIONAL OBJECTIVES
Students completing this course should be able
1.
To understand the role of food fermentation and preservation
2.
To list the major fermented food products and beverages
3.
To analyze methods used to control or destroy microorganism commonly
found in food.
UNIT I - THE SCIENCE UNDERPINNING FOOD FERMENTATIONS (9 hours)
Microorganisms: microbial metabolism– nutritional needs – environmental
impacts – metabolic events – Fermenters: Downstream processing – Some
general issues for a number of food stuffs.
157 Biotech-2013 SRM (E&T)
UNIT II - FOOD PRESERVATION (9 hours)
Preservation by Moist Heat: Heat Resistance of microorganisms and spores –
Decimal reduction time (D values) – 12D concept – Thermal Death Time curves –
Unit of lethality – determination of process lethality requirements – effective F
values – Preservation by low temperature: The behavior of microorganisms
under freezing and refrigeration environment – Growth and lethal effects of low
temperature treatments on microorganisms in raw and processed foods.
Preservation by drying, Chemicals and ionizing irradiation– Pulsed electric field
(PEF) method.
UNIT III - TECHNOLOGY OF FERMENTED BEVERAGES (9 hours)
Fermented products: Beer – Wine – Cider – Distilled alcoholic beverages –
Flavoured spirits and sake.
UNIT IV -TECHNOLOGY OF FERMENTED FOOD PRODUCTS (9 hours)
Fermented food products: Vinegar – cheese – yoghurt and other fermented milk
products – bread – Meat: sausage, bologna, Fermented vegetables: Sauerkaurt
– Kimchi – Soya sauce – Miso – Natto.
UNIT V- FOOD SANITATION (9 hours)
Basic principles of food plant sanitation: cleaning chemicals and sanitizers in
the food industry – Indicator organism – coliform bacteria – Hazard Analysis and
Critical Control Point (HACCP) Program – Good manufacturing
Practices(GMP’s)and microbiological standards.
TEXT BOOKS
1. Charles W.Bamforth, “Food, fermentation and microorganisms”, Blackwell
Publishing, 2005.
2. Frazier, W.C. and Dennis.D.Westhoff, “Food Microbiology”, 3rd Edn,Tata
McGraw Hill Publishing, 1978.
REFERENCES
1. Zeki Berk, “Food Process Engineering and Technology”, Academic Press,
2009.
2. James.M.Jay, Martin.J.Loessner, David.A. Golden, “Modern Food
Microbiology”, 7th Edn, 2005.
3. Paul SinghR., Dennis R. Heldman, “Introduction to Food Engineering”, 4th
Edn, Academic Press, 2009.
158 Biotech-2013 SRM (E&T)
BT1057 FOOD AND BEVERAGE FERMENTATION TECHNOLOGY
Course Designed by
Department of Biotechnology
1.
Student outcomes
a
b
c
d
e
f
g
h
i
j
k
x
x
x
2.
Mapping of instructional
objectives with student
outcomes
2
1
3
3.
Category
General(G)
Basic
Sciences(B)
Engg. Sci. &
Tech. Arts (E)
Professional
Subjects (P)
x
4.
Broad Area
Biotechnology
Bioprocess
Engineering
Chemical Engineering
--
x
--
5.
Approval
23rd Meeting of Academic Council, May 2013
BT1058
BIOCHEMICAL REACTION ENGINEERING
L
T
P
C
Total No. of Contact Hours – 45
3
0
0
3
Prerequisite
CH1051 and CH1054
PURPOSE
This course helps the students to develop a clear understanding of the
fundamentals of chemical and biochemical reaction engineering.
INSTRUCTIONAL OBJECTIVES
To familiarize
1.
Basic concepts of reaction kinetics and reactor types
2.
Various aspects of design for single, multiple reactions and Effects of
temperature and pressure on conversion
3.
Kinetics of Biochemical reaction systems
UNIT I - REACTION KINETICS (9 hours)
Kinetics of homogeneous reactions: Law of mass action – Rate equation –
concentration-dependent term of a rate equation – temperature- dependent term
of a rate equation – predictability of reaction rate from theory – Elementary– non-
elementary reactions and their mechanisms– Interpretation of batch reactor
data: constant volume batch reactor – varying-volume batch reactor –
temperature and reaction rate, Search for a rate equation.
UNIT II - IDEAL REACTORS (9 hours)
Introduction to reactor design – Ideal reactors for a single reaction: ideal batch
reactors – Steady-state mixed flow reactors – steady-state plug flow reactors.
159 Biotech-2013 SRM (E&T)
UNIT III - SINGLE AND MULTIPLE REACTIONS (9hours)
Design for single reactions: size comparison of single reactors – multiple-
reactor systems – recycle reactor – Design for parallel reactions: Irreversible
first-order reactions in series.
UNIT IV - TEMPERATURE AND PRESSURE EFFECTS (9 hours)
Single reactions: heats of reaction from thermodynamics – equilibrium
constants from thermodynamics – optimum temperature progression – heat
effects – adiabatic operations, non-adiabatic operations.
UNIT V - BIOCHEMICAL REACTION SYSTEMS (9 hours)
Enzyme fermentation – Microbial fermentation: substrate limiting microbial
fermentation – product limiting microbial fermentation- Batch and mixed flow
fermenters.
TEXT BOOKS
1. Octave Levenspiel, "Chemical Reaction Engineering", 3rd Edn, John Wiley &
Sons , Singapore, 1999.
2. Scott Fogler H., "Elements of Chemical Reaction Engineering", 2nd Edn.,
Prentice Hall of India, New Delhi, 1995.
REFERENCES
1. Smith J.M., "Chemical Engineering Kinetics", 3rd Edn., McGraw Hill, New
Delhi, 1981.
2. Ronald.W.Missen,Charles.A.Mions,Bradley.A.Saville, "Introduction to
Chemical Reaction operation and Kinetics", John Wiley and Sons, Singapore,
1999.
BT1058 BIOCHEMICAL REACTION ENGINEERING
Course Designed by
Department of Biotechnology
1.
Student outcomes
a
b
c
d
e
f
g
h
i
j
k
x
x
x
2.
Mapping of instructional
objectives with student
outcomes
2
3
1
3.
Category
General(G)
Basic
Sciences (B)
Engg. Sci. &
Tech. Arts(E)
Professional
Subjects (P)
x
4.
Broad Area
Biotechnology
Bioprocess
Engineering
Chemical Engineering
x
--
--
5.
Approval
23rd Meeting of Academic Council, May 2013
160 Biotech-2013 SRM (E&T)
BT1059
BIOREMEDIATION TECHNOLOGY
L
T
P
C
Total No. of Contact Hours - 45
3
0
0
3
Prerequisite
Nil
PURPOSE
The PURPOSE of this course is to introduce the use of living organisms such as
plants and microbes or their systems to the treat contaminants. In addition, the
course is expected to develop an efficient, eco-friendly and economical novel
alternative treatment technologies.
INSTRUCTIONAL OBJECTIVES
1.
To impart sufficient scientific understanding of the current environmental
tribulations and global concern.
2.
To focus the process of bioremediation, mechanisms, types, success
stories& monitoring strategies.
3.
To focus the advance molecular techniques to facilitate bioremediation
technology.
4.
To focus on advanced nuclear remediation program.
5.
To apply the concepts of bioremediation technology to the real time
problems.
UNIT I - BIOREMEDIATION (9 hours)
Introduction to Bioremediation: Types of Bioremediation, Factors affection
Bioremediation .Bioremediation Mechanisms.Limitations of
Bioremediations.Microbes for Bioremediation :Essential Chararcteristics of
Microbes for Bioremediation, Microbial Adapadation for Adverse conditions.
Microbes involved in Bioremediation. Metabolic process involved in
bioremediation. Bioremediation Techniques : Insitu & Exsitu bioremediation
techniques. Phytoremediation.
UNIT II - SPECIFIC BIOREMEDIATION TECHNOLOGIES (9 hours)
Application, specific advantages and disadvantages of specific bioremediation
technologies- land farming, prepared beds, biopiles, composting, bioventing,
biosparging, pump and treat method, constructed wet lands, use of bioreactors
for bioremediation. Phytoremediation, restoration of coal mines a case study.
161 Biotech-2013 SRM (E&T)
UNIT III - ENVIRONMENTAL GENOMICS & PROTEOMICS MOLECULAR
TECHNIQUES (9 hours)
Environmental Metagenomics – Introduction Pure culture and in consortium ;
Cultivable and Non-cultivable microbial analysis; Recombination DNA technology
and DNA cloning; Types of vectors, applications of recombination DNA
technology. Molecular fingerprinting techniques (RFLP, T-RFLP, ARISA, DGGE,
rDNA library, and FISH) Stable isotope probing (SIP); Suppressive subtractive
hybridization (SSH); Differential expression analysis (DEA).Microarrays &
Metagenome sequencing. Next-generation sequencing approaches to
metagenomics. Applications of Proteomics in Metagenomics Challenges with MS
Analysis.
UNIT IV - NUCLEAR WASTE BIOREMEDIATION (9 hours)
Spent fuel characterisation, storage and disposal; Partitioning, transmutation and
conditioning; Measurement of Radioactivity in the environment; Basic actinide
research.
UNIT V - HEAVY METAL AND OIL SPILL BIOREMEDIATION (9 hours)
Heavy metal pollution & sources; Microbial interactions with heavy metals -
resistance &tolerance ;Microbial transformation; Accumulation and
concentration of metals. Biosorption of heavy metals by microbial biomass and
secondary metabolites – Biosurfactants. Advantages of biosurfactants over
chemical surfactants.; Biotechnology and oil spills; Improved oil recovery.
TEXT BOOKS
1. Bruce E. Rittmann, Perry L. McCarty, “Environmental Biotechnology:
Principles and Applications” McGraw-Hill, 2001.
2. Phillip L. Buckingham, Jeffrey C. Evans,” Hazardous Waste Management”
Waveland Pr Inc; Reissue edition 1, 2010.
3. Agarwal S. K., “Environmental Biotechnology”, APH Publishing, 2000.
4. Rajendran P., P. Guansekaran, “Microbial Bioremediation”, Mjp Publishers,
2011.
REFERENCES
1. Agarwal S. K., “Environmental Biotechnology”, APH Publishing, 2000.
2. Martin Alexander, “Biodegradation & Bioremediation”, Academic press,
1999.
162 Biotech-2013 SRM (E&T)
BT1059 BIOREMEDIATION TECHNOLOGY
Course Designed by
Department of Biotechnology
1.
Student outcomes
a
b
c
d
e
f
g
h
i
j
k
x
x
2.
Mapping of instructional
objectives with student
outcomes
1
4
2
3.
Category
General(G)
Basic
Sciences (B)
Engg. Sci. &
Tech. Arts (E)
Professional
Subjects (P)
x
4.
Broad Area
Biotechnology
Bioprocess Engineering
Chemical
Engineering
x
--
--
5.
Approval
23rd Meeting of Academic Council, May 2013
BT1060
METAGENOMICS
L
T
P
C
Total No. of Contact Hours – 45
3
0
0
3
Prerequisite
Nil
PURPOSE
The purpose of this course is to provide focus on next generation DNA
sequencing technology to describe the ecological roles of microbial communities
in different environments. It also provides how the metabolic functions, taxonomic
distribution, diversity, evenness and species richness of microbial communities
varies across environment.
INSTRUCTIONAL OBJECTIVES
1.
To use metagenomic data to describe the taxonomic make-up, functional
potential and ecological processes of microbial communities from a range of
environments
2.
To apply next generation sequencing technology.
3.
To assemble and annotate genomes by identifying genes
UNIT I - ENVIRONMENTAL GENOMICS (9 hours)
Environmental Metagenomics – Introduction; Pure culture and in consortium ;
Cultivable and Non-cultivable microbial analysis; Recombination DNA technology
and DNA cloning; Types of vectors, applications of recombination DNA
technology; Molecular fingerprinting techniques (RFLP, T-RFLP, ARISA, DGGE,
rDNA library, and FISH); Stable isotope probing (SIP); Suppressive subtractive
163 Biotech-2013 SRM (E&T)
hybridization (SSH); Differential expression analysis (DEA); Microarrays &
Metagenome sequencing; Next-generation sequencing approaches to
metagenomics
UNIT II - ENVIRONMENTAL PROTEOMICS (9 hours)
Protein separations before digestion; One-dimensional SDS-PAGE, Two-
dimensional SDS-page, Problems with 2d-SDS-PAGE, Preparative IEF, High-
performance liquid chromatography; Protein separations after digestion: Mass
spectrometers for protein and peptide analysis, Instrumentation, MALDI-TOF-MS.
The TOF mass analyzer, Pros and cons of MALDI, Protein identification by
peptide mass fingerprinting, Peptide mass fingerprinting: analytical approach,
Peptide mass fingerprinting: complications, Software tools for peptide mass
fingerprinting, Finding the matches, Applications of Proteomics in Metagenomics;
Challenges with Metagenomic Analysis
UNIT III - LIBRARY CONSTRUCTION & ANALYSIS OF METAGENOMIC
LIBRARIES (9 hours)
Cataloging microbes: phylogenetic tree and construction - Construction of a
metagenomic library; Analysis of Metagenomic Libraries; Sequence-based
Metagenomics Analysis; Function-based Metagenomics Analysis; Phylogenetic
analysis and Comparative genomics Softwares & Tools
UNIT IV - METAGENOMICS CASE STUDIES (9 hours)
Metagenomic analysis of soil microbial communities; Metagenomic analysis of
marine microbial communities; Metagenome of the Microbial Community in
Acid Mine Drainage ;Metagenomic Analysis of Bacteriophage; Metagenomics
and Its Applications to the Study of the Human Microbiome; Archaeal
Metagenomics: Bioprospecting Novel Genes and Exploring New Concepts.
UNIT V - METAGENOMICS IN ENVIRONMENTAL STUDIES (9 hours)
Application of Metagenomics to Bioremediation ; Applications of Metagenomics
for Industrial Bioproducts; Escherichia coli host engineering for efficient
metagenomic enzyme discovery; Next-generation sequencing approaches to
metagenomics; Stable isotope probing: uses in metagenomics; DNA sequencing
of uncultured microbes from single cells
TEXT BOOKS
1. Joanna R. Freeland, Heather Kirk, Stephen Petersen, “Molecular Ecology”,
Mc Graw Hill, 2nd Edition “2012.
2. Beebee T.J.C., D G. Rowe,” An Introduction to Molecular Ecology”, Mc
Graw Hill, 2004.
164 Biotech-2013 SRM (E&T)
REFERENCES
1. Diana Marco Universidad Nacional de Cordoba, Argentina, “Metagenomics:
Theory, Methods and Applications”, Caister Academic Press, 2010.
2. Diana Marco Universidad Nacional de Cordoba, Argentina “Metagenomics:
Current Innovations and Future Trends”, Caister Academic Press, 2011.
BT1060 METAGENOMICS
Course Designed by
Department of Biotechnology
1.
Student outcomes
a
b
c
d
e
f
G
h
i
j
k
x
x
2.
Mapping of instructional
objectives with student
outcomes
1
4
2
3.
Category
General (G)
Basic
Sciences(B)
Engg. Sci. &
Tech. Arts (E)
Professional
Subjects (P)
x
4.
Broad Area
Biotechnology
Bioprocess
Engineering
Chemical Engineering
x
--
--
5.
Approval
23rd Meeting of Academic Council, May 2013
BT1061
BIOENERGY
L
T
P
C
Total No. of Contact Hours – 45
3
0
0
3
Prerequisite
Nil
PURPOSE
The purpose of this course is to provide an understanding of fundamental
concepts in understanding biofuel/bioenergy; renewable feedstocks, their
production, availability and attributes for biofuel/bioenergy production.
INSTRUCTIONAL OBJECTIVES
1.
To provide a thorough understanding of various renewable feedstocks of
importance their availability and attributes for biofuels production.
2.
To provide a thorough understanding of the broad concept of second and
third generationbiofuel production from biomass and other low-cost agri-
residues and biowastes.
3.
To provide students with tools and knowledge necessary for biofuel facility
operations.
4.
To teach our students to analyze and design processes for biofuel
production.
5.
To teach Nanotechnology applications in bioenergy fields.
165 Biotech-2013 SRM (E&T)
UNIT I - ENERGY (9 hours)
Introduction; Resources: Renewable and non-renewable resources (Water,
Minerals, and Energy; Use and overexploitation; Classification and Sources of
Energy; Problems relating demand and supply of various energy sources; Coal,
Petroleum etc.
UNIT II - BIOMASS & ENERGY CROPS (9 hours)
Energy Crops : wood( Lignocellulose) – Degradation by microorganisms and
pathway studies. Sugar and Starch crops - Degradation by microorganisms and
pathway studies. Oil seeds crops - Degradation by microorganisms and
pathway studies.Hydrocarbon producing crops - Degradation by microorganisms
and pathway studies.
UNIT III - BIOFUELS (9 hours)
First Generation Biofuels : Bioethanol , – Production meachnisms by microbes,
Second Generation Biofuels: Methane and Hydrogen – Production mechanisms
by microbes, Factors affecting Biogas yields. Third Generation Biofuels :
Biobutanol. Biodesel from algae.
UNIT IV - CLEAN COAL TECHNOLOGY (9 hours)
Principles of Microbial Metal Leaching: Leaching Mechanisms: Models of
Leaching Mechanisms. Factors Influencing Bioleaching.Bacterial Attachment on
Mineral Surfaces Microbial Diversity in Bioleaching Environments.Case Studies of
Bioleaching Applications: Commercial-Scale Copper Ore Bioleaching; Bacterial
oxidation of Chalcophyire and pyrite; Reactor Bioleaching of Fly Ash; Shake Flask
Bioleaching of Electronic Scrap; Bioremediation of Metal-Contaminated Sites.
UNIT V - SPECIAL TOPICS (9 hours)
From Microbes to Megawatts – Microbial Fuel Cells - Types of Biological fuel
cells – Working Principle - Applications of Biological Fuel cells. Biofilm - Theory
and Applications.Biosensor - Theory and Applications. Environmental
Nanobiotechnology : Nano carbons, Nano catalysts, Nano aerosols & gels for
waste water treatment.
TEXT BOOKS
1. Samir K. Khanal, “Anaerobic Biotechnology for Bioenergy Production:
Principles and Applications”, Wiley-Blackwell Publishing, 2008.
2. David M. Mousdale, “Biofuels: Biotechnology, Chemistry, and Sustainable
Development “CRC Press, 2008.
3. Gupta, Vijai Kumar; Tuohy, Maria G. (Eds.), “Biofuel Technologies Recent
Developments”, Springer, 2013.
166 Biotech-2013 SRM (E&T)
REFERENCES
1. Robert C. Brown, “Biorenewable Resources: Engineering New Products from
Agriculture”, Wiley-Blackwell Publishing, 2003.
2. Pogaku, Ravindra; Sarbatly, Rosalam Hj. (Eds.), “Advances in Biofuels”,
Springer, 2013.
BT1061 BIOENERGY
Course Designed by
Department of Biotechnology
1.
Student outcomes
a
b
c
d
e
f
g
h
i
j
k
x
x
2.
Mapping of instructional
objectives with student
outcomes
1
4
2
3.
Category
General (G)
Basic
Sciences(B)
Engg. Sci.&
Tech Arts (E)
Professional
Subjects (P)
x
4.
Broad Area
Biotechnology
Bioprocess Engineering
Chemical
Engineering
x
--
--
5.
Approval
23rd Meeting of Academic Council, May 2013
BT1062
ENVIRONMENTAL MICROBIOLOGY
L
T
P
C
Total No. of Contact Hours - 45
3
0
0
3
Prerequisite
Nil
PURPOSE
The PURPOSE of this course is to provide an understanding of fundamental
concepts and underlying principles in the Environmental Microbiology. In addition,
the course is expected to develop identifying community members and
determining their metabolic and ecological roles in the community.
INSTRUCTIONAL OBJECTIVES
1.
To impart sufficient scientific understanding of the basic concepts in
ecological processes of microbial communities from a range of
environments.
2.
To apply the concepts of extremophiles and its taxonomic make up.
3.
To focus the general understanding of the extremophiles and its uses in
Biotechnology.
4.
To provide experience in various techniques to study extremophiles.
167 Biotech-2013 SRM (E&T)
UNIT I - BIODIVERSITY (9 hours)
Introduction to microbial biodiversity – distribution, abundance, ecological
niche.Types- Bacterial, Archael and Eucaryal. Characteristics and classification of
Archaebacteria.Thermophiles: Classification, hyperthermophilic habitats and
ecological aspects. Extremely Thermophilic Archaebacteria, Thermophily,
commercial aspects of thermophiles.Applications of thermozymes. Methanogens:
Classification, Habitats, applications.
UNIT II - ALKALOPHILES AND ACIDOPHILES (9 hours)
Classification, alkaline environment, soda lakes and deserts, calcium alkalophily
Applications . Acidophiles: Classification, life at low pH, acidotolerence,
applications.
UNIT III - HALOPHILES AND BAROPHILES (9 hours)
Classification, Dead Sea, discovery basin, cell walls and membranes – Purple
membrane, compatible solutes.Osmoadaptation / halotolerence.Applications of
halophiles and their extremozymes. Barophiles: Classification, high-pressure
habitats, life under pressure, barophily, death under pressure.
UNIT IV - NITROGEN FIXING BACTERIA (9 hours)
Introduction to Nitrogen Fixation –biological fixation ; Nitrogenase enzyme and its
activity & physiology ; Nod genes – nif genes – I; Nod genes – nif genes – II ;
Regulation of nitrogen fixation genes;Process of nodulation- Bacteriods;Transfer
of nif genes to microorganisms;National interests and Economic considerations;
UNIT V - SPACE MICROBIOLOGY (9 hours)
Aims and objectives of Space research. Life detection methods a] Evidence of
metabolism (Gulliver) b] Evidence of photosynthesis (autotrophic and
heterotrophic) c] ATP production d] Phosphate uptake e] Sulphur uptake .Martian
environment (atmosphere, climate and other details).Antartica as a model for
Mars. Search for life on Mars, Viking mission, Viking landers, and Biology box
experiment. Gas exchange, Label release and pyrolytic release experiments
.Monitoring of astronauts microbial flora: Alterations in the load of medically
important microorganisms, changes in mycological autoflora, and changes in
bacterial autoflora.
TEXT BOOKS
1. Christon J. Hurst, Ronald L. Crawford, Guy R. Knudsen, Michael J.
McInerney, “Manual of Environmental Microbiology,” 2nd edition, ASM
Press. 2001.
168 Biotech-2013 SRM (E&T)
2. Hans G. Schlegel, “General Microbiology,” Seventh Edition, Cambridge
University Press Publisher, 1993.
3. Lansing M Prescott, John P.Harley and Donald A. Klein, “Microbiology,” Mc
Graw Hill publication, Seventh edition, 2008
4. Michael J. Pelczar, “Microbiology,” Tata McGraw-Hill,1993.
REFERENCES
1. Maier, R.M. Pepper, I.L and Gerba, “Environmental Microbiology,” C.P.
Academic press, 2000.
2. Joanne M Willey, Joanne Willey, “Prescott's Microbiology,” 8th edition,
2009, ISBN:0077350138
BT1062 ENVIRONMENTAL MICROBIOLOGY
Course Designed by
Department of Biotechnology
1.
Student outcomes
a
b
c
d
e
f
g
h
i
j
k
x
x
2.
Mapping of instructional
objectives with student
outcomes
1
4
2
3.
Category
General (G)
Basic
Sciences(B)
Engg. Sci.&
Tech. Arts (E)
Professional
Subjects (P)
x
4.
Broad Area
Biotechnology
Bioprocess Engineering
Chemical
Engineering
x
--
--
5.
Approval
23rd Meeting of Academic Council, May 2013
BT1063
ANIMAL THERAPEUTICS
L
T
P
C
Total No. of Contact Hours - 45
3
0
0
3
Prerequisite
Nil
PURPOSE
To impart knowledge on various animal sources for the production of
therapeutics.
INSTRUCTIONAL OBJECTIVES
1.
To provide guidelines for the product development and drug testing.
2.
To educate the students for the in vitro and in vivo source of drugs and
their applications.
3.
To know the values of ethics in animal study.
169 Biotech-2013 SRM (E&T)
UNIT I - HISTORY OF PRODUCT DEVELOPMENT (9 hours)
History of the product development for the human kind - guidelines for the
product industry for the uses of animal and human cells.Product development
and drug testing – Common product safety tests.
UNIT II - METHODS AND SOURCES OF PRODUCT STUDY (8 hours)
In vitro and in vivo method of products – selection and culture of cell lines,
types of human and animal cell lines. History, assessment and types of animal
models for the products.
UNIT III - COMPARATIVE MEASUREMENT OF SOURCES (9 hours)
Methods of production of therapeutics -Comparative status of drugs from both
natural and cell line or animal models.Animal models and their applications –
Fruit fly and Zebra fish.
UNIT IV - PRODUCTS AND THEIR SPECIFIC SOURCES 10 hours)
Production of medicinally important products from in vitro sources–
Hormones, blood clotting factors, interferons, plasminogen activator,
erythropoietin and antitrypsin.
UNIT V - ETHICAL ISSUES AND PATENT APPROVAL (9 hours)
Fundamental issues for cell-line banks in biotechnology and regulatory affairs
-Ethical issues on animal model research.Patents in the drug industry: Legal
and Ethical Issues-Drug Approval in the European Union and the United States.
TEXT BOOKS
1. Allan B. Haberman, “Animal Models for Therapeutic Strategies”, Cambridge
Healthtech Institute, 2010.
2. Gary Walsh, “Pharmaceutical Biotechnology: Concepts and Applications”,
John Wiley & Sons Ltd, 2007.
REFERENCES
1. Freshney R.I., “Culture of Animal cells”, 5th Edition, Wiley Publications, 2010.
2. Jim E. Riviere and Mark G. Papich (Eds), “Veterinary Pharmacology and
Therapeutics,” Wiley-Blackwell, 9th Ed., 2009.
170 Biotech-2013 SRM (E&T)
BT1063 ANIMAL THERAPEUTICS
Course Designed by
Department of Biotechnology
1.
Student outcome
a
b
c
d
e
f
g
h
i
j
k
x
x
x
2.
Mapping of instructional
objectives with student
outcome
3
2
1
3.
Category
General(G)
Basic
Sciences(B)
Engineering
Sciences and
Technical Arts(E)
Professional
Subjects(P)
x
4.
Broad Area
Biotechnology
Bioprocess
Engineering
Chemical
Engineering
x
-
-
5.
Approval
23rd Meeting of Academic Council, May 2013
BT1064
TRANSGENIC ANIMALS
L
T
P
C
Total No. of Contact Hours - 45
3
0
0
3
Prerequisite
Nil
PURPOSE
This course explains the fundamentals of transgenic animals and their potential
applications.
INSTRUCTIONAL OBJECTIVES
1.
To import knowledge on basic techniques for transgenic study and their
issues.
2.
To understand about the sources for transgenic animals and the products.
UNIT I - HISTORICAL ASPECTS OF TRANSGENIC STUDY (9 hours)
History and Concepts of transgenic techniques of gene transfer, principles of
animal cloning. Social, ethical, religious, environmental and other regulatory
issues related to transgenic animal technology.
UNIT II - PROMOTORS AND VECTORS (8 hours)
Suitable promoters for expression of transgenes - eukaryotic expression
vectors, detection of transgenes in the new born.
171 Biotech-2013 SRM (E&T)
UNIT III - METHODS OF TRANSGENESIS (10 hours)
Methodology for production of transgenic animals - Retroviral vector method -
DNA micro injection - Engineered embryonic stem cell method, Oocyte culture.
Transgenic animals - Dolly, Cattle, Goat, Pigs and Rat.
UNIT IV - DEVELOPMENT OF ANIMAL MODELS (9 hours)
Knock out and knock in technology-Advances in development of animal
models for human diseases using transgenic animal technology - cystic
fibrosis, atherosclerosis, obesity.
UNIT V - PRODUCTS FROM TRANSGENIC SOURCES (9 hours)
Applications of transgenic animals for the production - therapeutic proteins -
better nutrition, disease resistance, xenotransplantation. Bioindicator- transgenic
Glofish.
TEXT BOOKS
1. Carl A. Pinkert (Eds.), “Transgenic Animal Technology – A laboratory
handbook”, Academic press, USA, 2002.
2. Ranga, M.M., “Transgenic Animals”, Riddhi International, India, 2006.
3. Louis-Marie Houdebine, “Transgenic Animals- Generation and Use”, CRC
Press, 1997.
4. Jose Cibelli, Robert P. Lanza, Keith H.S. Campbell and Michael D. West
(Eds.), “Principles of Cloning”, Academic press, USA, 2002.
REFERENCES
1. Ralf Pörtner, “Animal Cell Biotechnology: Methods and Protocols (Methods
in Biotechnology)”, Humana Press; 2nd edition (April 5, 2007).
2. Joseph Panno, “Animal Cloning: The Science of Nuclear Transfer (New
Biology)”, Facts on File Science Library, (October 2004).
172 Biotech-2013 SRM (E&T)
BT1064 TRANSGENIC ANIMALS
Course Designed by
Department of Biotechnology
1.
Student outcome
a
b
c
d
e
f
g
h
i
j
k
x
x
2.
Mapping of instructional
objectives with student
outcome
1
2
3.
Category
General
(G)
Basic
Sciences(B)
Engineering
Sciences and
Technical Arts (E)
Professional
Subjects(P)
x
4.
Broad Area
Biotechnology
Bioprocess
Engineering
Chemical
Engineering
x
-
-
5.
Approval
23rd Meeting of Academic Council, May 2013
BT1065
VACCINE BIOTECHNOLOGY
L
T
P
C
Total No. of Contact Hours - 45
3
0
0
3
Prerequisite
Nil
PURPOSE
To understand the historical developments of vaccine production and to current
methods and their management.
INSTRUCTIONAL OBJECTIVES
1.
To provide the knowledge on conventional to recent technology of vaccine
production.
2.
To learn the types of vaccine, immunological effects and regulatory
guidelines.
UNIT I - HISTORICAL DEVELOPMENTS OF VACCINE (9 hours)
History of vaccine development-Conventional strategies for vaccine
improvement, live attenuated and killed vaccines, types of adjuvant, quality
control, preservation and monitoring of microorganisms in seed lot systems.
UNIT II - BETTER PRODUCTION (9 hours)
Technology related to monitoring - temperature, sterilization, environment,
quality assurance and related areas. Production techniques- growing the
microorganisms in maximum titer, preservation techniques, freeze drying.
173 Biotech-2013 SRM (E&T)
UNIT III - TYPES, METHODS AND APPLICATION (10 hours)
Types of vaccines- subunit vaccine, synthetic vaccines, DNA vaccines, virus like
particles, recombinant vaccines and edible vaccines.Uses of nanoparticles in
vaccine application.
UNIT IV - DELIVERY METHODS (8 hours)
Immunomodulators-Innovative methods of delivery of immunogens through
liposomes, microsperes, ISCOMS.
UNIT V - GUIDELINES FOR THE MANAGEMENT (9 hours)
Regulatory issues-Environmental concerns with the use of recombinant
vaccines-Disease security and biosecurity principles and OIE guidelines such
as seed management-Method of manufacture- inprocess control, batch control,
test on final products.
TEXT BOOKS
1. Ronald W. Ellis, “New Vaccine Technologies”, Landes Bioscience, 2001.
2. Cheryl Barton, “Advances in Vaccine Technology and Delivery”, Espicom
Business Intelligence, 2009.
REFERENCES
1. Thomas J. Kindt, Richard A. Goldsby, Barbara A. Osborne and Janis Kuby,
“Kuby Immunology”, 6th edition W.H. Freeman and company, 2007.
2. Ramadass, P., “Animal Biotechnology – Recent concepts and
Developments”, MJP Publications, India, 2008.
BT1065 VACCINE BIOTECHNOLOGY
Course Designed by
Department of Biotechnology
1.
Student outcome
a
b
c
d
e
f
g
h
i
j
k
x
x
2.
Mapping of instructional
objectives with student
outcome
2
1
3.
Category
General(G)
Basic
Sciences(B)
Engineering
Sciences and
Technical Arts (E)
Professional
Subjects(P)
x
4.
Broad Area
Biotechnology
Bioprocess
Engineering
Chemical
Engineering
x
-
-
5.
Approval
23rd Meeting of Academic Council, May 2013
174 Biotech-2013 SRM (E&T)
BT1066
MARINE BIOTECHNOLOGY
L
T
P
C
Total No. of Contact Hours - 45
3
0
0
3
Prerequisite
Nil
PURPOSE
To provide an adequate knowledge of the wealth of marine and aquaculture
resources. In addition to know the techniques on the resource management.
INSTRUCTIONAL OBJECTIVES
1.
To understand the economically important marine animals and their potency
as toxins and drugs.
2.
To learn the knowledge on the degradation process for discharged wastes.
3.
To know the diseases of aquaculture animals and its management.
UNIT I - ECONOMICAL IMPORTANCE OF MARINE RESOURCES (9 hours)
Wealth of the sea -Economically important marine animals – finfishes, shrimp,
crab, edible oysters and pearl oysters.
UNIT II - TOXINS AND THEIR ACTION (9 hours)
Marine toxins from animals – sources and pharmacological potentials of
tetrodotoxins, conotoxins and ciguateratoxins.
UNIT III - POTENTIAL BIOACTIVE COMPOUNDS (10 hours)
Bioactive compounds from the sea - source and benefits of antioxidants,
collagen, gelatin, heparin, chitosan, omega 3 fatty acids and carotinoids.
UNIT IV - OIL AND SOLID WASTE DEGRADATION (8 hours)
Oil spillage – methods of degradation in coastal waters, Algal blooms-
Biodegradation of pesticides and heavy metals discharged coastal waters-
Management of solid wastes disposed into coastal waters.
UNIT V - DISEASE AND WATER QUALITY MANAGEMENT (9 hours)
Diseases associated with cultured shrimps and fishes-disease management -
antibiotics, Immunostimulants, diagnostic kits. Water quality management in
hatcheries and grow out ponds.
175 Biotech-2013 SRM (E&T)
TEXT BOOKS
1. Milton Fingerman and Rachakonda Nagabhushanam, “Recent Advances in
Marine Biotechnology (Series) Biomaterials and Bioprocessing”, Science
Publishers, 2009.
2. Proksch and Werner E.G.Muller, Frontiers in Marine Biotechnology, Horizon
Bioscience, 2006.
3. Le Gal, Y., Ulber, R, “Marine Biotechnology I: Advances in Biochemical
Engineering/Biotechnology”, (Series editor: T. Scheper) Springer-Verlag
Berlin Heidelberg. Vol. 96, 2005.
4. Le Gal, Y., Ulber, R “Marine Biotechnology II: Advances in Biochemical
Engineering/Biotechnology”, (Series editor: T. Scheper) Springer-Verlag
Berlin Heidelberg. Vol. 97, 2005.
REFERENCES
1. Attaway D.H. and Zaborsky O.R., (eds). “Marine Biotechnology: Volume I,
Pharmaceuticals and Bioactive Natural Products”, New York: Plenum. 1993.
2. Powers D.A., “New frontiers in marine biotechnology: Opportunities for the
21st century”, In: Marine Biotechnology in the Asian Pacific Region (eds). C.
G. Lundin and R. A. Zilinskas. The World Bank and SIDA. Stockholm. 1995.
BT1066 MARINE BIOTECHNOLOGY
Course Designed by
Department of Biotechnology
1.
Student outcome
a
b
c
d
e
f
g
h
I
j
k
x
x
x
2.
Mapping of instructional
objectives with student
outcome
1
2
3
3.
Category
General(G)
Basic
Sciences(B)
Engineering
Sciences and
Technical Arts(E)
Professional
Subjects(P)
x
4.
Broad Area
Biotechnology
Bioprocess
Engineering
Chemical
Engineering
x
5.
Approval
23rd Meeting of Academic Council, May 2013
176 Biotech-2013 SRM (E&T)
BT1067
PHYTOCHEMICAL TECHNIQUES
L
T
P
C
Total No. of Contact Hours - 45
3
0
0
3
Prerequisite
Biochemistry
PURPOSE
The course is designed to provide an understanding of the range of metabolites
synthesized by plants and the varied applications of these metabolites. The
student will gain an understanding of theoretical principles related to the metabolic
pathways leading to the synthesis of these metabolites in vivo and various
modern techniques for the purification and identification. The course would be
relevant for students who wish introduction to the latest techniques and theory
related to the range of industrially important compounds including
pharmaceuticals, cosmetics, food-flavours, biofuels and oils to substitute
unsustainable products.
INSTRUCTIONAL OBJECTIVES
1.
To explore the structural complexity and diversity of pharmaceutically
relevant plant metabolites
2.
To impart knowledge in principles underlying plant secondary metabolism
3.
To present an overview of different classes of metabolites present in plants
4.
To understand the technologies underlying the isolation, purification,
quantitation and identification of plant metabolites
5.
To appreciate the diversity of plant metabolites and their utility
UNIT I - OVERVIEW OF PLANT SECONDARY METABOLITES (9 hours)
Drugs from plants - Insecticides and rodenticides- Industrially important Plant
products Essential Oils, Fatty Oils & Waxes, Fibers & Fiber Plants, Forest
Products: Wood and Cork, Forest Resources, Gums & Resins, Rubber and Other
Latex Products, Tanning, Dye & Processing Materials.
UNIT II - METABOLITES DERIVED FROM THE SHIKMATE CHORISMATE
PATHWAY (9 hours)
Plant acids, fatty acids and lipids, alkanes and related hydrocarbons,
polyacetylenes, sulphur compounds. nitrogen compounds-amino acids, amines,
alkaloids, cyanogenic glycosides, inoles, purines, pyrimidines and cytokinins,
chlorophylls.
177 Biotech-2013 SRM (E&T)
UNIT III - METABOLITES DERIVED FROM THE MALONIC AND MEVALONIC ACID
PATHWAYS (9 hours)
Phenols and phenolic acids, phenylpropanoids, flavonoid pigments, anthocyanins,
flavaonols and flavones, tanins, quinones. essential oils, diterpenoids and
gibberellins, triterpenoids, steroids and catotenoids.
UNIT IV - CONVENTIONAL METHODS IN PLANT ANALYSES (9 hours)
Introduction- selection of plants and plant parts - methods of extraction and
isolation, methods of separation, methods of identification, analysis of results and
application
UNIT V - ADVANCES IN PLANT ANALYTICAL TECHNIQUES (9 hours)
GC - HPLC- HPTLC-OPLC – NMR-MS Microarray- RT PCR- RNA SEQ –
fluorescence and confocal microscopy - CHN analysis - X ray crystallography
TEXT BOOK
1. Harbone J. B., “Phytochemical Method--A guide to modern techniques of
plant analysis,” Chapman and Hall Third edition. 2005.
REFERENCES
1. Sarker, S. D., Latif, Z. and Gray,A.I. “Methods in Biotechnology -Natural
Product Isolation” Second Edition, Humana Press 2006
2. Raman N. “Phytochemical Techniques” – New India Publishing agency First
Edition, 2006.
BT1067 PHYTOCHEMICAL TECHNIQUES
Course Designed by
Department of Biotechnology
1.
Student outcomes
a
b
c
d
e
f
g
h
i
j
K
x
x
x
x
x
2.
Mapping of instructional
objectives with student
outcomes
1-5
1-5
1-5
1-5
1-5
3.
Category
General
Subjects (G)
Basic
Sciences(B)
Engg. Sci. &
Tech. Arts (E)
Professional
Subjects(P)
x
4.
Broad Area
Biotechnology
Bioproc.
Engg.
Chemical Engineering
x
5.
Approval
23rd Meeting of Academic Council, May 2013
178 Biotech-2013 SRM (E&T)
BT1068
PLANT HORMONES AND SIGNAL
TRANSDUCTION
L
T
P
C
Total No. of Contact Hours - 45
3
0
0
3
Prerequisite
BT1022
PURPOSE
The course is designed to provide an understanding of the regulation of various
physiological and metabolic processes by signalling growth regulating
substances. The student will gain an understanding of theoretical principles
related to transduction of signals between different plant parts which in turn
regulate plant growth and development.
INSTRUCTIONAL OBJECTIVES
1.
To introduce basic concepts related to discovery and physiological effects
of plant growth regulators
2.
To impart an understanding of control of various physiological and
developmental mechanisms by hormones
3.
To give an insight into the cellular and molecular modes of action of
phytohormones
4.
To explore the nature of signaling molecules and receptors involved in plant
development
5.
To explore the prospects related to potential applications of principles
underlying signal transduction mechanisms.
UNIT I - AUXINS (9 hours)
Introduction – The emergence of the auxin concept, biosynthesis and metabolism
of auxin, auxin transport, physiological effects of auxin, developmental effects of
auxin – auxin receptors and signal transduction pathways of auxin.
UNIT II - GIBBERELLINS (9 hours)
The discovery of the gibberellins, effects of gibberellin on growth and
development, Biosynthesis and metabolism of gibberellin, physiological
mechanisms of gibberellin-induced growth, signal transduction -cereal aleuronic
layers.
UNIT III - CYTOKININS (9 hours)
The discovery, identification and properties, Biosynthesis, metabolism and
transport of cytokinins, biological roles of cytokinins, cellular and molecular
modes of cytokinin action
179 Biotech-2013 SRM (E&T)
UNIT IV - ETHYLENE (9 hours)
Structure, biosynthesis and measurement of ethylene, developmental and
physiological effects, cellular and molecular modes of ethylene action- Ethylene
receptors
UNIT V - ABSCISIC ACID (9 hours)
Occurrence, chemical structure and measurement of ABA, developmental and
physiological effects of ABA, ABA Receptors - cellular and molecular modes of
ABA action
TEXT BOOKS
1. Lincoln Taiz and Eduardo Zeiger, “Plant Physiology”, Third edition. Panima
Publishing corporation, 2003.
2. Davies, P. J., “Plant Hormones - Biosynthesis, Signal Transduction, Action”,
Third Edition, Springer 2010.
REFERENCES
1. Perrot-Rechenmann, C. and Hagen, G.,“Auxin Molecular Biology” , Springer
2002.
2. Takahashi, N., Phinney, B., MacMillan, J., “Gibberellins ” , Springer 1990.
BT1068 PLANT HORMONES AND SIGNAL TRANSDUCTION
Course Designed by
Department of Biotechnology
1.
Student outcomes
a
b
c
d
e
f
g
h
I
j
K
x
x
x
x
x
2.
Mapping of instructional
objectives with student
outcomes
1-5
1-5
1-5
1-5
1-5
3.
Category
General
Subjects (G)
Basic
Sciences(B)
Engg. Sci. &
Tech. Arts
(E)
Professional
Subjects(P)
x
4.
Broad Area
Biotechnology
Bioprocess
Engineering
Chemical Engineering
x
5.
Approval
23rd Meeting of Academic Council, May 2013
180 Biotech-2013 SRM (E&T)
BT1069
PATHOGENESIS RELATED PROTEINS IN
PLANTS
L
T
P
C
Total No. of Contact Hours - 45
3
0
0
3
Prerequisite
BT1014
PURPOSE
The course is designed to provide an understanding of the up-regulation of
various proteins during pathogen infection and other related abiotic stress
conditions. The student will gain an understanding of theoretical principles related
to mechanisms of resistance to pathogens at molecular level which can be
applied for developing technologies to improve resistance in plants.
INSTRUCTIONAL OBJECTIVES
1.
To presents an overview of the expression of proteins during biotic and
abiotic stress conditions
2.
To gain an understanding of mechanisms of disease resistance in plants
3.
To give an insight into principles related to plant insect interactions
4.
To project the application of the knowledge of PR proteins for genetic
manipulation of plants
UNIT I - PR PROTEINS AND THEIR FUNCTIONS (9 hours)
Introduction- induction of PR proteins, occurrence and properties of PRs and PR
like proteins, Functions of PR proteins
UNIT II - PR-1 AND PR-2 PROTIENS (9 hours)
PR-1-Introduction-Characterization-acidic, basic proteins, proteins from other
organisms, functions Expression - pathogens/wounds, salicylic acid, ethylene and
other hormones, UV light and developmental stimuli. PR-1 promoter analysis. PR-
2- Introduction- Structural classes of β-1,3-Glucanases and PR-2 Nomenclature,
Biological functions of β-1,3-Glucanases, Regulation of β-1,3-Glucanases
expression.
UNIT III - PLANT CHITINASES AND PR-5 FAMILY (9 hours)
Introduction-PR-3, 4, 8, 11- Structure of proteins, catalytic mechanisms and
specificities, structure and regulation of the genes, functions. PR-5-Occurrence,
biological properties of TLPs, regulation of TLP expression, cDNAs and genes for
TLPs
181 Biotech-2013 SRM (E&T)
UNIT IV - PATHOGEN INDUCED PR GENE EXPRESSION AND RIP (9 hours)
Introduction – Signals and putative receptors that activate PR gene expression, PR
gene activation by pathogens, transcriptional regulation and genetic studies of PR
gene expression. Ribosome inactivating proteins – structure, function and
engineering- Pathogen induced gene expression PR-6- Occurrence and structure
of plant proteinase inhibitors, Plant microbe interaction, Plant insect interaction
and its regulation.
UNIT V - PLANT DEFENSINS AND PR GENES IN TRANSGENIC PLANTS(9 hours)
Introduction – Protein structure, antimicrobial activities, structure activity
relationships, mode of action, expression of plant defensin genes and its
contribution for host defense. Transgenic plants – over expression of PR proteins
– antifungal and insecticidal proteins, PR proteins in Rice.
TEXTBOOK
1. Swapan K. Datta and Muthukrishnan, “Pathogenesis –Related Proteins in
plants”, CRC Press, 1999.
BT1069 PATHOGENESIS-RELATED PROTEINS IN PLANTS
Course Designed by
Department of Biotechnology
1.
Student outcomes
a
b
c
d
e
f
g
h
i
j
K
x
x
x
x
x
2.
Mapping of instructional
objectives with student
outcomes
1-4
1-4
1-4
1-4
1-4
3.
Category
General(G)
Basic
Sciences(B)
Engg. Sci. &
Tech. Arts (E)
Professional
Subjects (P)
x
4.
Broad Area
Biotechnology
Bioprocess
Engineering
Chemical Engineering
x
5.
Approval
23rd Meeting of Academic Council, May 2013
182 Biotech-2013 SRM (E&T)
BT1070
REGULATION OF GENE EXPRESSION IN
PLANTS
L
T
P
C
Total No. of Contact Hours - 45
3
0
0
3
Prerequisite
BT1014
PURPOSE
The course is designed to provide an understanding of the molecular concepts
related to the control of plant growth and development. The student will gain an
understanding of theoretical principles related to gene expression which in turn
can be applied for genetic manipulation of plants. The course will be relevant for
students who wish an insight of molecular switches that regulate plant growth
and development and who wish to explore these principles for improvement of
plant production.
INSTRUCTIONAL OBJECTIVES
1.
To explore the complexity of plant genome
2.
To appreciate the tolerance ranges in plants to abiotic stress factors and
apply the principles for manipulation of plants to improve tolerance
3.
To understand and apply various strategies for increasing resistance in
plants to biotic stress
4.
To explore applications of various chemical and environmental signals
involved in plant development
5.
To understand the applications of various plant derived control systems for
crop improvement
UNIT I - ORGANIZATION OF PLANT GENOME (9 hours)
Introduction-, genome size and organization - the chloroplast genome -
organization, inheritance and expression. Mitochondria genome - organization -
expression - male sterility - gene structure and gene expression - regulation,
implication for plant transformation - protein targeting, heterologous promoters.
Transposons - Ac and Ds transposable elements in maize, transposon tagging
and retrotransposons- Arabidopsis
UNIT II- TRANSGENIC TECHNOLOGIES FOR COMBATING ABIOTIC (9 hours)
Herbicide resistance- Use of herbicides in modern agriculture- strategies for
engineering herbicide resistance - environmental impact- abiotic stress-water
deficit stress – ROS -various approaches for engineering tolerance.
UNIT III - TRANSGENIC TECHNOLOGIES FOR COMBATING BIOTIC STRESS
(9 hours)
Pest resistance-nature and scale of insect / pest damage to crop - GM strategies -
Bt approach to insect resistance-copy nature strategy - insect resistant crops and
183 Biotech-2013 SRM (E&T)
food safety - plant-pathogen interactions - natural disease resistance pathways -
biotechnological – Genetic manipulation based approaches to disease resistance -
plant viruses - transgenic approach-PDR
UNIT IV - PROMOTER SYSTEMS BASED ON CHEMICAL AND ENVIRONMENTAL
SIGNALS (9 hours)
Tn10 encoded Tet repressor - ecdysteroid agonist inducible control of gene
expression in plants - regulatory mechanism of the GR, GVG system-
construction, induction experiments, characteristics and prospects of steroid
inducible system - Copper controllable expression system - basis and functioning,
modifications to overcome background expression in roots, vectors for CC gene
expression - tissue specific antisense experiments- conditional lethal genes and
practical uses-organization and types of heat shock promoters- heat shock
transcription factors, heat shock promoter in transgenic plants - examples- nitrate
inducibility- gene expression using nitrite reductase gene promoter
UNIT IV - PROMOTER SYSTEMS BASED ON PLANT DEVELOPMENTAL
PROCESSES (9 hours)
Wound inducible genes and hormone responsive elements-Introduction - Multiple
phases of wound response, Mechanism of wound induction, Additional hormone
factors. Hormone responsive elements- ocs/as-1 AuxRE, natural composite
AuxREs, Synthetic composite and simple AuxREs - abscisic acid inducible
promoters - developmental targeting of gene expression by senescence specific
promoter.
TEXT BOOKS
1. Adrian Slater, Nigel W. Scott and Mark R.Fowler. “Plant Biotechnology-The
genetic manipulation of plants”, Oxford university press 2008.
2. Reynolds P. H. S. (ed.) “Inducible Gene Expression in Plants”, CAB
International First Edition 1999.
REFERENCES
1. Carole L. Bassett, “Regulation of gene expression in plants - The role of
transcript structure and processing”. Springer, First Edition 2007.
2. Filipowicz and Horn, “Post transcriptional control of gene expression in
plants”, Springer, First Edition 1996.
3. Balbas and Lorence “Recombinant gene expression - Reviews and
protocols”, Springer Second Edition 2004.
184 Biotech-2013 SRM (E&T)
BT1070 REGULATION OF GENE EXPRESSION IN PLANTS
Course Designed by
Department of Biotechnology
1.
Student outcome
a
b
c
d
e
f
g
h
i
j
k
x
x
x
x
x
2.
Mapping of instructional
objectives with student
outcome
1-5
1-5
1-5
1-5
1-5
3.
Category
General
(G)
Basic
Sciences(B)
Engineering Sciences
and Technical Arts (E)
Professional
Subjects(P)
x
4.
Broad Area
Biotechnology
Bioprocess
Engineering
Chemical
Engineering
x
5.
Approval
23rd Meeting of Academic Council, May 2013
BT1071
BIOBUSINESS
L
T
P
C
Total No. of Contact Hours - 45
3
0
0
3
Prerequisite
Nil
PURPOSE
The purpose of Biobusines course is to provide specialized knowledge from the
Biotechnology sector for effective business education for tomorrow’s industry
leaders.
INSTRUCTIONAL OBJECTIVES
1.
To develop knowledge and skills to master the future challenges of the
biotechnology industries.
2.
To understand the Life Cycle Process of Biotech R&D and Marketing
3.
To study and develop product launch and marketing strategies for a highly
regulated industry.
4.
To Learn how to analyze and manage different stakeholder interests (Pharma
& biotech, patients and physicians.
UNIT I - BIOTECHNOLOGY BUSINESS MANAGEMENT (9 hours)
Principles & Practices of Management & Communication Skills.Basics of
Biotechnology and Bioinformatics – Business, Marketing, Materials, & Logistics
Management.Biotechnology plant, Project & Production management. Intellectual
property rights & technology transfer Innovation & knowledge management.
185 Biotech-2013 SRM (E&T)
UNIT II - BIOTECHNOLOGY INDUSTRY & BUSINESS MANAGEMENT (9 hours)
Antibody Technologies; Antisense & RNAi Technology ; Biologics ; Biomarkers ;
Biomaterials; Cell Culture ; DNA Sequencing ; Drug Development ; Emerging
Technology ; Enzymes ; Gene Therapy ; Genetic Engineering ; Genomics ;
Informatics ; Instrumentation & Equipment ; Microarray ; Molecular Biology ;
Nanomedicine ; Personalized Medicine ; Proteomics ; Regenerative Medicine ;
Stem Cell ; Tissue Engineering.
UNIT III - PHARMACEUTICAL BUSINESS INDUSTRY & MANAGEMENT (9 hours)
Pharmaceutical Industry: Issues, Structure & Dynamics; Legal, Regulatory, and
Ethical Issues in the Pharmaceutical Industry; U.S Healthcare System &
Pharmaceutical Managed Markets.Pharmaceutical Marketing: Pharmaceutical
Marketing Research; Pharmaceutical Product Management; Managing the
Pharmaceutical Sales Organization
UNIT IV - AGRICULTURE BUSINESS MANAGEMENT (9 hours)
Management of Agricultural Input Marketing; Fertilizer Technology & Management;
Management of Agro Chemical Industry; Management of Agro Chemical Industry;
Seed Production Technology & Management; Case studies : Banana; sugarcane,
wheat, rice etc., Transgenic Seeds/Crops (Soybean, Corn, Cotton, & Others
(Includes Canola, Wheat, Rice, and Potato among Others), and Biopesticides.
UNIT V - HEALTH CARE BUSINESS MANAGEMENT (9 hours)
Economics of Health Care and Policy, Managed Care and Market Structure,
Financial Management of Health Institutions, Health Policy, Health Services
Delivery: A Managerial Economic Approach, Legal Aspects of Health Care,
Management of Care for the Elderly, Health Care Marketing, Comparative Health
Care Systems, E-Health: Business Models and Impact, Health Care
Entrepreneurship.
TEXT BOOKS
1. Mark J. Ahn, Michael A. Alvarez, Arlen D. Meyers, Anne S York, “Building the
Case for Biotechnology”, 1st edition, 2011.
2. Peter Kolchensky, “The Entrepreneurship Guide to a Biotech startup”,
Evelexa, 2011.
3. Maureen D. MacKelvey, Luigi Orsenigo, “The Economics of Biotechnology”
Edward Elgar Pub; 1 edition, 2001.
4. Steven B. Kayne, “Pharmacy Business Management” ,Pharmaceutical Press,
2005.
186 Biotech-2013 SRM (E&T)
REFERENCES
1. Damian Hine, John Kapeleris, “Innovation and Entrepreneurship in
Biotechnology”, Concepts, Theories and Case”, Edward Elgar Publishing,
2008.
2. Yali Friedman, “Best practices in biotechnology business Development”,
Logos Press, 2008.
BT1071 BIOBUSINESS
Course Designed by
Department of Biotechnology
1.
Student outcomes
a
b
c
d
e
f
g
h
i
j
k
x
x
2.
Mapping of instructional
objectives with student
outcomes
1
2
3
3.
Category
General(G)
Basic
Sciences(B)
Engg.Sci.&
Tech. Arts (E)
Professional
Subjects (P)
x
4.
Broad Area
Biotechnology
Bioprocess Engineering
Chemical
Engineering
x
--
--
5.
Approval
23rd Meeting of Academic Council, May 2013
187 Biotech-2013 SRM (E&T)
AMENDMENTS
S.No.
Details of Amendment
Effective from
Approval with
date

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