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An Integrated Solution

Tissue Structure Information Modeling (TSIM) and BioAssemblyBot comprise an integrated workstation

that empowers physicians, researchers, engineers, and scientists to design, visualize, and print 3D virtual

models of complex tissue structures. The patent pending innovation advances the current capability of

3D printing to enable biological tissue assembly, a key step in realizing functional biological structures

for human purposes.

Capabilities

•Image Import and Manipulation – Patient specific image

sets, such as ultrasound, MRI or CT scans, are converted to

3D representations. These representations are then used to

guide the printing.

•3D Structure Design and Modeling – The user creates a

3D model in TSIM using the medical image sets as a guide.

•Materials Inventory Management – TSIM supports a

comprehensive material data management system that

provides the ability to define, create, query, update,

administer, and attach data attributes (e.g. cell type,

viscosity, etc.) to objects within the model.

Tissue Structure Information Modeling (TSIM)

TSIM is an intuitive software tool that empowers doctors and

scientists to design, visualize, simulate and analyze 3D computer

models of complex tissue structures. TSIM software utilizes a

digital prototyping workflow that enables scientists to work with

3D computer models of complex tissue structures before they are

created. This capability allows scientists to enhance the precision

and functional specifications of any tissue structure design.

TSIM™ & BioAssemblyBot™

Tissue Structure Information Modeling Software and 3D Bioprinter

•Medical Images

•Tissue Designs

•Experimental Models

•Cell Systems

Tissue

Assembly

3D Modeling

& Analysis

3D Modeling

& Analysis

www.AdvancedSolutions.com/LifeSciences

1901 Nelson Miller Parkway, Louisville, KY 40223 • 1-877-438-2741

Accelerating

Biomedical

Discovery &

Innovation

more info >

more info >

Capabilities

•Six-axis robotic arm – Enables multi-directional printing functionality

•Modular end effector design – Multiple unique printing cartridges and “bioinks” can be utilized during a single

print run, enhancing the range and scope of task functionality and tissue assembly.

•Automated print operations – Automatically calibrates the position of the robot arm using laser sensors. The arm

then moves to the storage rack, selects the proper syringe, and dispenses the specified amount of material to

construct the biological model.

•Intuitive touch screen interface – Integrated human-machine interface gives the user control of print operations

•Video camera – Displays live feed of printing activity from inside the BioAssemblyBot

•Flexible printing environment with bench-top footprint – Sized to provide a flexible printing area and to fit

medical laboratory environments

BioAssemblyBot

Once the 3D model is complete in TSIM, the data is sent to the

BioAssemblyBot workstation for printing. Utilizing a six-axis

robotic arm, the BioAssemblyBot precisely builds 3D tissue

structures and models.

Direct

print to

well plates

Tissue

Assembly

www.AdvancedSolutions.com/LifeSciences

1901 Nelson Miller Parkway, Louisville, KY 40223 • 1-877-438-2741

LED Lights

Robot Arm

Video Camera

Robot End Effector

RJ45 / 120V / Air

Integrated HMI

Syringe Storage

Work Stage

Print

complex

geometries

Store up to

10 bioinks

more info >

www.AdvancedSolutions.com/LifeSciences

1901 Nelson Miller Parkway, Louisville, KY 40223 • 1-877-438-2741

Advanced Solutions Life Sciences is dedicated to the discovery, design, development and commercialization of integrated software and hardware

solutions for the fields of science that involve living organisms, molecular biology, and biotechnology. We seek to improve the quality and

standard of life through innovative solutions in health, agriculture, medicine, medical device manufacturing, pharmaceutical industry, and food

Sample Applications

“This is a game changer.

The BioAssemblyBot and

TSIM solution is enabling

us to rapidly advance and

expand our biological

capability for tissue repair,

improved drug therapy and

organ replacement. ”

Dr. Jay Hoying

Division Chief, Cardiovascular Therapeutics

Cardiovascular Innovation Institute

Vascular tree – cell system and assay

Heart with vein – organ model

Nose – surgical model

Aortic valve – experimental tissue system

Tissue models – cell system and assay

Bone replacement tissue molding

– implant system