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Release Notes
Chromeleon 7
Chromatography Data System
Software Version 7.2 SR5 • March 2017

Chromeleon 7
Copyright
For Research Use Only. Not for use in diagnostic procedures. Copyright © 2009-2017 Thermo Fisher Scientific
Inc. All rights reserved.
Trademarks
ACQUITY, Alliance and Waters are registered trademarks of Waters Corporation. ACQUITY, Alliance and Waters
are registered trademarks of Waters Corporation. Agilent is a registered trademark of Agilent Technologies.
Microsoft, Windows 8.1 Pro, .NET Framework and SQL Server are registered trademarks of Microsoft
Corporation. PerkinElmer and Clarus are registered trademarks of PerkinElmer Inc. Shimadzu is a trademark of
Shimadzu Corporation. WibuKey is owned by Wibu Systems.
All other trademarks are property of Thermo Fisher Scientific Inc. and its subsidiaries.
Thermo Fisher Scientific Inc. provides this document to its customers with a product purchase to use in the
product operation. The document is copyright protected; any reproduction of the whole or any part of this
document is strictly prohibited, except with the written authorization of Thermo Fisher Scientific Inc.
This document is provided “as is”. The contents of this document are subject to being changed, without notice,
in future revisions.
Thermo Fisher Scientific Inc. makes no representations that this document is complete, accurate, or error-free.
Thermo Fisher Scientific Inc. assumes no responsibility and will not be liable for any errors, omissions, damage,
or loss that might result from any use of this document, even if the information in the document is followed
properly.
This document is not part of any sales contract between Thermo Fisher Scientific Inc. and a purchaser. This
document shall in no way govern or modify any Terms and Conditions of Sale. The Terms and Conditions of Sale
shall govern all conflicting information between the two documents.

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Table of Contents
1 Introduction ............................................................................................................................. 7
2 Other Documentation ............................................................................................................. 8
3 What’s New in Chromeleon 7.2 SR5........................................................................................ 9
3.1 Thermo Scientific Instrument Drivers ............................................................................... 9
3.1.1 Thermo Scientific TRACE 1300E – Updated Driver [SWFR-2336] ............................... 9
3.1.2 Thermo Scientific Analog to USB Adapter (A2D) – Updated Driver [SWFR-1476]...... 9
3.1.3 Thermo Scientific Integrion – Updated Driver [SWFR-2074, SWFR-2134] ................. 9
3.1.4 Thermo Scientific Vanquish HPG Flex – New Driver [SWFR-1905, SWFR-2064] ........ 9
3.1.5 Thermo Scientific TRACE GC 1110 – Updated Driver [SWFR-1323, SWFR-1324,
SWFR-1325, SWFR-1326] ...................................................................................................... 9
3.1.6 Thermo Scientific Vanquish Charged Aerosol Detector – Updated Driver [SWFR2057] 10
3.1.7 Thermo Scientific AS-AP and UltiMate WPS-3000 – Updated Drivers [SWFR-1283,
SWFR-1329]........................................................................................................................... 10
3.2 IQ/OQ/PQ .......................................................................................................................... 10
3.2.1 HPLC IQ Enhancements [SWFR-2104, SWFR-2141] .................................................... 10
3.2.2 HPLC OQ/PQ Enhancements [SWFR-2104] ................................................................. 10
3.3 Firmware ........................................................................................................................... 10
3.4 Third Party Instrument Drivers ......................................................................................... 10
3.4.1 SofTA 2300 ELSD – New Driver [SWFR-609] ............................................................... 11
3.4.2 Agilent LC – New Driver [SWFR-1784]......................................................................... 11
3.4.3 Agilent ICF – Additional Modules ................................................................................ 11
3.4.4 Agilent 6850/6890 GC – Additional Options [CM7-21508] ......................................... 11
3.5 Security and Infrastructure ............................................................................................... 11
3.5.1 Improved Security for XVault and local Data Vaults [SWFR-2114] ............................. 11
3.5.2 Detect Manipulations on Raw Files [SWFR-2055]....................................................... 12
3.5.3 Default to MS SQL Server 2014 SP2 Express[SWFR-2054] .......................................... 12
3.5.4 Support for MS SQL Server 2014 SP2 [SWFR-2373] .................................................... 12
3.5.5 Oracle Database 12c Support for Chromeleon 7 [SWFR-1663] .................................. 12
3.5.6 Oracle Database 12c on Red Hat Enterprise Linux 7 Support for Chromeleon 7
[SWFR-2335] ......................................................................................................................... 12
3.5.7 Windows 10 Support for Chromeleon 7 [SWFR-1766] ............................................... 12
3.5.8 Citrix XenApp 7.6 using Windows Server 2012 R2 [SWFR-1818] ................................ 12
3.5.9 Improved Client License Handling for NFP [SWFR-2128]............................................ 12
3.5.10

Microsoft .Net Framework 4.6.2 Support [SWFR-1767] ........................................ 13

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3.5.11

Updated Transport Security [SWFR-2099] ............................................................. 13

3.5.12 Updated Cryptographic Strength for Electronic Signatures and Connection
Strings [CM7-20699] ............................................................................................................. 13
3.5.13

Reduced Number of Database Commits during Data Acquisition [SWFR-1726] ... 13

3.5.14

Raw File Cache on the IPC for Sequence Download [SWFR-1525, CM7-19263] ... 13

3.6 Support Central Rollout for Large Scale Installations ....................................................... 14
3.6.1 Support Deployment with OS Images [SWFR-2117] ................................................... 14
3.6.2 Detect System Activity (e.g. Running Queue) [SWFR-2118] ....................................... 14
3.6.3 Prevent / Defer Installation while System is Active (e.g. Running Queue) [SWFR2113] 14
3.6.4 Maintenance Window for Chromeleon Stations [SWFR-2119] .................................. 14
3.6.5 Command Line Option for Chromeleon Domain Controller and OrgUnit
Parameters [SWFR-1691]...................................................................................................... 15
3.7 Client Features .................................................................................................................. 15
3.7.1 Save Query Results as a New Sequence [SWFR-764].................................................. 15
3.7.2 RTS Processing Methods: Updated Tolerances for All Components [SWFR-2175] .... 15
3.7.3 Allow Definition of a Print Range for Electronic Reports [SWFR-1433] ...................... 15
3.7.4 Extension for Report Variables peak.nCalpoints and peak.nCalDisabled [CM720981] ................................................................................................................................... 15
3.7.5 GC-MS Environmental Water Analysis Extension Pack ............................................... 15
3.7.6 USP Tailing and Width for Riders and Poorly Resolved Peaks [SWFR-2187] .............. 15
3.8 Compliance Features ........................................................................................................ 15
3.8.1 Global Policy ................................................................................................................ 15
3.8.2 User Management Privileges ...................................................................................... 16
3.8.3 User Management, Admin Console: Session Timeout [SWFR-244]............................ 16
3.8.4 Capture Logoff in Audit Trail [CM7-21883] ................................................................. 16
3.8.5 Additional Detail in Audit Trail Entries [SWFR-1715] .................................................. 16
3.8.6 Sequence Editor: Improvements to ‘Save as’ Privilege [CM7-20486] ........................ 16
3.8.7 Object Version Display in File Listing [SWFR-2214] .................................................... 16
3.8.8 Improved Traceability for Sequences after Failed Upload [CM7-20508] ................... 17
3.8.9 Logged-on User Name in Administration Console [CM7-21328]................................ 17
3.8.10

Audit Trail Entries for Print & Export [CM7-7608, CM7-22422] ............................ 17

3.9 Time Zone Information ..................................................................................................... 17
3.9.1 Time zone information for every Time Stamp Display [SWFR-2123, CM7-20485]..... 17
3.9.2 New Report Category “Time Zone Information” [SWFR-1798] .................................. 17
3.9.3 Show Information about Time Zone [SWFR-1899] ..................................................... 18
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3.10 Administrative Features .................................................................................................... 18
3.10.1 Audit Trails for System Events [SWFR-2048] ......................................................... 18
3.10.2 Administration Console: Additional Audit Trails [SWFR-2025, SWFR-241, SWFR1692] 18
3.10.3 Standardized Comments and Authorization for Specific Actions [SWFR-57,
SWFR-1946, SWFR-1947] ...................................................................................................... 18
3.10.4

Comments for Administrative Changes [SWFR-2203] ........................................... 18

3.10.5

Schedule Tasks using Local Scheduler [SWFR-943]................................................ 18

3.10.6

Extensions to Discovery List [SWFR-1907, SWFR-1901, SWFR-1949, SWFR-1908] 19

3.10.7

Notify Admin by Email when Account is Locked [SWFR-1561] .............................. 19

3.11 User Management ............................................................................................................ 19
3.11.1 Audit Trail for User Account Cloning [SWFR-2024]................................................ 19
3.11.2

Ability to Set User Account Inactive / Retired [SWFR-1271] ................................. 19

3.11.3

Grouping and Filtering for the User List [SWFR-1272, SWFR-1062] ...................... 19

3.11.4

Default Role for User [SWFR-1909] ........................................................................ 19

3.12 Chromeleon 6 Migration ................................................................................................... 19
3.12.1 Chromeleon 6 Data Import in Chromeleon 7 – Signature Data from Signed
Results [SWFR-1130] ............................................................................................................. 19
3.12.2

Direct Import of Chromeleon 6 Backup Archives (*.cmb files) [SWFR-63]............ 20

3.12.3

Querying Chromeleon 6.8 Datasources with Chromeleon 7 [SWFR-507] ............. 20

4 Limitations and Known Issues ................................................................................................. 21
4.1 Limitations with Thermo Scientific Instruments............................................................... 21
4.1.1 Compatibility of Chromeleon 7.2 SR5 and SII for Xcalibur.......................................... 23
4.1.2 Mass Spectrometers and Windows 10 ....................................................................... 23
4.1.3 Compatibility with Foundation 3.1.............................................................................. 23
4.2 Limitations with the Waters Driver Pack .......................................................................... 23
4.3 Limitations with Agilent ICF .............................................................................................. 24
4.4 Limitations with Other Third Party Instruments............................................................... 26
4.5 Other Limitations .............................................................................................................. 27
4.6 Obsolete Drivers ............................................................................................................... 29
4.7 Defects Under Investigation ............................................................................................. 29
4.7.1 Empty Inject Time and GUID Fields in the Injection Record [CM7-22738] ................. 29
4.7.2 Instrument Audit Trails Are not Properly Saved/Written on the local Data Vault
[CM7-23051] ......................................................................................................................... 29

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4.8 Functional Differences between Chromeleon 7.2 and Chromeleon 6.8 .......................... 30
5 Resolved Issues ........................................................................................................................ 31
6 Backward/Forward Compatibility Issues ................................................................................. 59
6.1 Thermo Scientific Vanquish Charged Aerosol Detector [CM6-23499] ............................. 59
6.2 Thermo Scientific Vanquish Autosampler [CM6-23405] .................................................. 59
6.3 Thermo Scientific TriPlus RSH ........................................................................................... 59
6.4 Thermo Scientific TriPlus 300 HS [CM6-22430] ................................................................ 59
6.5 Thermo Scientific TriPlus LS-100 ....................................................................................... 59
6.6 Thermo Scientific TSQ Quantiva ....................................................................................... 59
6.7 Thermo Scientific TSQ Quantiva and Endura .................................................................... 60
6.8 TSQ Quantiva and Endura Instrument Method [CM7-18759].......................................... 60
6.9 Signed Sequences [CM7-16374] ....................................................................................... 60
7 Appendix .................................................................................................................................. 61
7.1 Release Notes.................................................................................................................... 61
7.2 Online Help ....................................................................................................................... 61
7.3 Contributed Content ......................................................................................................... 61

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1 Introduction
The Thermo Scientific™ Chromeleon™ 7 Chromatography Data System (CDS) is a new-generation
chromatography data system that provides the fastest path from samples to results. Building upon
market-leading innovations of prior Chromeleon software releases – such as dynamic interactive data
displays, an integrated database for rapid data retrieval, and spreadsheet-based reporting –
Chromeleon 7 features a modern user interface, comprehensive new tools for peak detection, and an
innovative workflow management framework, all of which speed up learning, simplify operation, and
deliver results with greater efficiency than any other chromatography data system.
This new version, Service Release 5 of Chromeleon 7.2 CDS, provides updated instrument control for
instruments from Thermo Fisher Scientific and other vendors. This release also adds significant
enhancements in data security and integrity, compliance, and enterprise administration as well as
improved software rollout tools for use in enterprise environments. In addition the system
performance in a number of different areas has been significantly improved. There are many other
new features and improvements which are listed in more detail below.
The software is developed using modern software development tools and technologies that improve
performance, sustainability and extendibility.
Backward compatibility with Chromeleon 6 is maintained to the greatest practicable extent and
further improved with this release, to provide an easy migration path.

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2 Other Documentation
Chromeleon is provided with many other documents that will help you to learn more about the
software. Their scope is described in the Document Overview, which is delivered in printed form with
the Chromeleon installation media, but also available in electronic form on the installation disk in the
Documents folder.
Please refer to the Installation Guide for information regarding:
•

System Requirements

•

Supported Operating Systems and Databases

•

Required Third-Party Software

•

Compatibility with Previous Versions

•

Installing and configuring the Chromeleon software
Tip: The Glossary describes Chromeleon-specific terms and common abbreviations used
throughout the documentation.

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3 What’s New in Chromeleon 7.2 SR5
Chromeleon 7.2 SR5 implements a large number of new features with a lot of options and new
possibilities including optimizations to its Wide Area Network performance in order to fully enable
large global installations. This document will only give a short overview of all features without going
into much detail. For more details, refer to the Online Help.

3.1 Thermo Scientific Instrument Drivers
This chapter lists updated Thermo Scientific™ drivers added to Chromeleon 7.2 SR5. For details on
supported options, required licenses, installation, and control, refer to the Online Help or the List of
Supported Instruments document found on the Chromeleon 7.2 SR5 DVD.

3.1.1 Thermo Scientific TRACE 1300E – Updated Driver [SWFR-2336]
With this Service Release, support is added for the Primary Auxiliary Gas Module.
Note: The TRACE™ 1300E GC only supports a Primary Auxiliary Gas Module and not a Secondary
module.

Note: Support for this module requires an update of the GC firmware to FW Pack 29.

3.1.2 Thermo Scientific Analog to USB Adapter (A2D) – Updated Driver [SWFR1476]
Maintenance Update 7.2 SR4 MUa introduced control for the new dual-channel models of A2D. This
new model of the A2D adds a second data channel and four extra relays. The two data channels and
eight relays can be assigned to a single instrument or can be shared between multiple instruments.

3.1.3 Thermo Scientific Integrion – Updated Driver [SWFR-2074, SWFR-2134]
Maintenance Update 7.2 SR4 MUa introduced support for dual-system configurations. With
Maintenance Update 7.2 SR4 MUb, support has been expanded to include more Dionex IonPac™
columns and other Dionex consumables for the Integrion™ platform.

3.1.4 Thermo Scientific Vanquish HPG Flex – New Driver [SWFR-1905, SWFR-2064]
Maintenance Update 7.2 SR4 MUb introduced support for the Thermo Scientific Vanquish Binary
Pump Flex (VF-P10-A). This pump has a pressure limit of 1034 bar and is compatible with all other
Vanquish modules.

3.1.5 Thermo Scientific TRACE GC 1110 – Updated Driver [SWFR-1323, SWFR-1324,
SWFR-1325, SWFR-1326]
With Maintenance Update 7.2 SR4 MUb the Thermo Scientific TRACE GC 1110 driver was updated to
add support for the following modules:
•

DID (Discharge Ionization Detector)

•

PID (Photo-ionization Detector)

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•

Methanizer

•

Valve Oven

3.1.6 Thermo Scientific Vanquish Charged Aerosol Detector – Updated Driver
[SWFR-2057]
Maintenance Update 7.2 SR4 MUb introduced support for the new transducer board for the Thermo
Scientific Vanquish Charged Aerosol detector (VH-D20-A, VF-D20-A). This update also allows for the
new board to be installed in situ.

3.1.7 Thermo Scientific AS-AP and UltiMate WPS-3000 – Updated Drivers [SWFR1283, SWFR-1329]
Since Maintenance Update 7.2 SR4 MUb, a blank injection will now trigger the inject relay, allowing
mass spectrometers run with SII to execute start up and shut down instrument methods on the
UltiMate™ WPS and AS-AP platforms. This feature was previously available (since Chromeleon 7.2
CDS SR2) for the Thermo Scientific Vanquish Autosampler.

3.2 IQ/OQ/PQ
3.2.1 HPLC IQ Enhancements [SWFR-2104, SWFR-2141]
Since Maintenance Update 7.2 SR4 MUb, HPLC IQ has been updated as follows:
•

Support for Vanquish Binary Pump Flex

•

Support for the previously released Omni Cell for the ECD-3000RS

Further details are available from the HPLC Instruments IQ V.4.00 Release Notes available in the
\Documents folder of this release.

3.2.2 HPLC OQ/PQ Enhancements [SWFR-2104]
Since Maintenance Update 7.2 SR4 MUb, HPLC OQ/PQ has been updated to support the Vanquish
Binary Pump Flex.
Further details are available from the HPLC OQ PQ V 9.00 Release Notes available in the \Documents
folder of this release.

3.3 Firmware
This release adds support of new firmware for new and updated instruments and modules. For an
overview of the firmware versions available with this release, please refer to the document
\Documents\List of Supported Instruments – Chromeleon 7.2 SR5.pdf on the Chromeleon disk.

3.4 Third Party Instrument Drivers
This chapter lists new and updated drivers added to Chromeleon 7.2 SR5. For details on supported
options, required licenses, installation, and control, refer to the Online Help and the List of Supported
Instruments document found on the Chromeleon 7.2 SR5 DVD.

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3.4.1 SofTA 2300 ELSD – New Driver [SWFR-609]
This release introduces a driver for the SofTA 2300 and 1300/1400 instruments. The 1300/1400
instrument is not compatible with European 50Hz power and therefore only available in Service
Mode. Please contact your local Thermo Fisher Scientific representative if you are interested in
controlling 1300 or 1400 modules.

3.4.2 Agilent LC – New Driver [SWFR-1784]
Chromeleon 7.2 SR5 includes a new suite of drivers, provided by Agilent Technologies, for control of
Agilent LC instruments. By using drivers provided directly by the hardware vendor, Agilent
Technologies and Thermo Fisher Scientific are able to ensure the fastest time to market for drivers
for new Agilent instruments, tighter integration with Chromeleon and an improved user experience
for Agilent LC instruments. The drivers are available as an optional component in the installation.
The new driver supports the vast majority of current Agilent LC instruments. For a complete list of
modules, see the List of Supported Instruments.
For more details about the drivers see Agilent documentation on the Chromeleon 7.2 SR5 DVD in
folder \Packages\Agilent Chromeleon Drivers\Documentation.
Note: This new driver will be the future platform for Agilent LC instruments. Thermo Fisher
Scientific recommends using the new driver where possible. During a transition period the
Agilent ICF driver provided by Thermo Fisher Scientific will still be available. However, the driver
will be phased out in the next major version of Chromeleon 7. In addition the existing, obsolete
Agilent 1200 driver will receive no further updates.

3.4.3 Agilent ICF – Additional Modules
This release of Chromeleon includes the Agilent Instrument Control Framework version A.02.04
which supports the latest HPLC instruments from Agilent, specifically the Infinity II series. The Agilent
ICF driver has been tested with additional modules. For a complete list of supported modules see the
List of Supported Instruments. For latest release information provided by Agilent Technologies,
including release notes and validation certificates, please see \Packages\Agilent Instrument Control
Framework\Documentation.
Note: Thermo Fisher Scientific recommends migrating to the new Agilent Chromeleon driver as
soon as possible. During a transition period the Agilent ICF driver provided by Thermo Fisher
Scientific will still be available. However, the driver will be phased out in the next major version
of Chromeleon 7.

3.4.4 Agilent 6850/6890 GC – Additional Options [CM7-21508]
Support has been added for the auxiliary temperature and pressure controls.

3.5 Security and Infrastructure
3.5.1 Improved Security for XVault and local Data Vaults [SWFR-2114]
This service release introduces a dedicated database administration account
“ChromeleonAdminLogin” that will be used by the system for administration purposes on local
Chromeleon Data Vaults. Local administrators will no longer be added to the group of data base
administrators. Existing Data Vaults and multi-user Data Vaults will not be changed.
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3.5.2 Detect Manipulations on Raw Files [SWFR-2055]
Previous releases of Chromeleon could not detect if a user with sufficient Windows privileges
manipulates files manually. This service release introduces cryptographic hashing for data objects so
that Chromeleon can verify if an object has been tampered with outside of Chromeleon. The option
is now available as a new Global Policy, “Raw Data”. The verification is triggered whenever a raw file
is accessed, i.e. when a sequence or instrument audit trail is opened for review or report.

3.5.3 Default to MS SQL Server 2014 SP2 Express[SWFR-2054]
Chromeleon 7.2 SR5 will install MS SQL Server 2014 SP2 Express by default for local Chromeleon 7
Data Vaults.
Note: Existing installations of SQL server will not be changed.

3.5.4 Support for MS SQL Server 2014 SP2 [SWFR-2373]
Networked Data Vaults can now use MS SQL Server 2014 SP2.

3.5.5 Oracle Database 12c Support for Chromeleon 7 [SWFR-1663]
Networked Data Vaults can now use Oracle Database 12c.

3.5.6 Oracle Database 12c on Red Hat Enterprise Linux 7 Support for Chromeleon 7
[SWFR-2335]
Networked Data Vaults can now use Oracle Database 12c running on Red Hat Enterprise Linux 7.

3.5.7 Windows 10 Support for Chromeleon 7 [SWFR-1766]
This release adds support for Windows 10. Chromeleon 7.2 SR5 has been tested with Windows 10
Enterprise 64 bit, Long Term Servicing Branch, Version 1607.
Note: The Windows 10 Automatic Updates feature may occasionally stop certain system services
and/or force a PC reboot, which will disrupt the operation of Chromeleon, including data
acquisition. It is recommended to set the "Active Hours" (when Windows won't perform updates)
to minimize the potential for interruptions to Chromeleon.

3.5.8 Citrix XenApp 7.6 using Windows Server 2012 R2 [SWFR-1818]
Chromeleon 7.2 SR5 is tested on Citrix XenApp 7.6 running on Windows Server 2012 R2.

3.5.9 Improved Client License Handling for NFP [SWFR-2128]
The Chromeleon 7 license system supports network failure protection to provide license features
even during a network outage scenario. However, it was only possible to get a license during network
outage if a valid license had been retrieved earlier during normal operation. This would not work for
instrument PCs where users never logged on before.
To improve the situation during network outage Chromeleon 7.2 SR5 checks if an instrument
controller is running and is consuming a Chromeleon Instrument Controller license that was retrieved
before the network failure. For this use case client license features will be automatically granted
locally during the network outage.
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3.5.10 Microsoft .Net Framework 4.6.2 Support [SWFR-1767]
Chromeleon 7.2 SR5 requires Microsoft .NET Framework 4.6.2. The framework is included in the
Chromeleon setup and installed automatically.

3.5.11 Updated Transport Security [SWFR-2099]
Prior versions of Chromeleon 7 are using certificates based on SSL 3.0 which has been obsoleted by
Microsoft in .NET 4.6. Chromeleon 7.2 SR5 updates this to the latest standards using SHA-256 and
TLS 1.2.
Components of Chromeleon 7.2 SR5 are always using the new transport security for communication.
For backwards compatibility Chromeleon can be configured to also enable old transport security so
that older Chromeleon components can connect. This setting is available in the local Discovery
Configuration and can be configured per Chromeleon station.
When installed anew, without previous Chromeleon 7 installation, old transport security will be
disabled by default. When updating a present installation old transport security will remain enabled
so that older Chromeleon stations can still communicate with the updated Chromeleon instance.

3.5.12 Updated Cryptographic Strength for Electronic Signatures and Connection
Strings [CM7-20699]
In previous releases, Chromeleon used RSA with 1024 bits for electronic signatures and connection
strings. This is no longer considered secure. In preparation to move to updated encryption this
release is able to decrypt new electronic signatures and connection strings based on 2048 bit RSA key
pairs. For backward compatibility with previous versions of Chromeleon the weaker keys are still
being used.

3.5.13 Reduced Number of Database Commits during Data Acquisition [SWFR-1726]
When using the replication framework the instrument controller continuously updates the database
during the data acquisition. Database commits are replicated to the central Data Vault. It has been
found that the number of database commits is unexpectedly high, thereby limiting the number of
instruments that a Data Vault service can handle in parallel. Chromeleon 7.2 SR5 reduces the update
frequency significantly to achieve a higher throughput for the Data Vault service. This will also result
in a better overall user experience when reading data while acquisition is running on the same Data
Vault.

3.5.14 Raw File Cache on the IPC for Sequence Download [SWFR-1525, CM7-19263]
This release introduces a raw file cache mechanism on the IPC to improve download performance.
There are situations when a previously downloaded raw data file may be required by another
Sequence that is downloaded very soon after.
Example situations include rerunning an acquired Sequence with extra injections appended or
running a "Fixed" Calibration Sequence where raw data is referenced in the Processing Method.
The raw file cache was available in Chromeleon 7.2 SR2 but was not available in Chromeleon 7.2
SR3/4 when using the replication framework.

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The new feature also resolves CM-19263, WAN performance is slow when restarting partially
acquired sequences, which was documented as a known limitation in previous versions of
Chromeleon 7.

3.6 Support Central Rollout for Large Scale Installations
Rolling out updates and patches in large and wide-spread installations of Chromeleon 7 is a
significant effort for administrators. The system therefore has been extended to provide means to
support and enable automated updates.
Note: Features in this section are mostly relevant for large Chromeleon installations. This usually
requires remote administration and management and makes it difficult to synchronize and
control administration and update activities. With these new features Chromeleon strives to
assist affected customers.

3.6.1 Support Deployment with OS Images [SWFR-2117]
The Chromeleon enterprise documentation for SR5 includes instructions for creating OS images for
IPCs or Chromeleon client computers. For more detail refer to the document CM7ID_320--CM7-IPCImage_Creation.docx.

3.6.2 Detect System Activity (e.g. Running Queue) [SWFR-2118]
It is undesirable to install updates to Chromeleon, Windows, or third party products while an
instrument queue is running on the system. Such updates may stop the Instrument Controller or
related services, or even cause a reboot and therefore interrupt data acquisition.
This release includes a command line tool “ChromeleonActivityCheck.EXE” for checking if
Chromeleon is currently busy acquiring data. The tool can be found on the Chromeleon DVD in the
folder \Tools\Chromeleon Activity Check.

3.6.3 Prevent / Defer Installation while System is Active (e.g. Running Queue)
[SWFR-2113]
When attempting to install, modify or repair Chromeleon in interactive installation mode while
instrument queues are running on the system, the installer will report a warning about the running
queues. The user has the choice to ignore the warning and continue installation, wait for the queues
to finish and retry installation, which will check the states of the queues again, or to cancel
installation.

3.6.4 Maintenance Window for Chromeleon Stations [SWFR-2119]
In Chromeleon 7.2 SR5 Administration Console a maintenance window for any Chromeleon station in
the Chromeleon Domain can be defined. Various settings are available. When the maintenance
window is set, users working on that computer will get notified in the Console. When entering the
Maintenance Window, running sequences are completed or stopped depending on what has been
defined in the settings and new sequences cannot be started anymore. The new functionality is
controlled by a new privilege “Manage Maintenance Window”.

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3.6.5 Command Line Option for Chromeleon Domain Controller and OrgUnit
Parameters [SWFR-1691]
The unattended setup of Chromeleon 7.2 SR5 supports new command line arguments to pre-define
Chromeleon Domain, OrgUnit and related parameters.

3.7 Client Features
3.7.1 Save Query Results as a New Sequence [SWFR-764]
It is now possible to save query results as a new sequence. This feature is also governed by a new
privilege “Create Sequence from Injection Query Results”.

3.7.2 RTS Processing Methods: Updated Tolerances for All Components [SWFR2175]
All 4% RTS tolerances (anion and cation) for the Retention Time Standard (RTS) processing methods
have been changed to 5% to ensure better identification of the expected components.

3.7.3 Allow Definition of a Print Range for Electronic Reports [SWFR-1433]
Maintenance Update 7.2 SR4 MUa introduced the ability to define which pages of an Electronic
report will be printed. The Print dialog box now lists the available sheets and allows these to be
included/removed from the current print task.

3.7.4 Extension for Report Variables peak.nCalpoints and peak.nCalDisabled [CM720981]
When using calibration with average values, it was not possible to report the (total) number of
calibration points, only the number of averaged points could be seen. In addition, the number of
disabled points would be reported as zero until all injections of a particular standard had been
disabled. These can now be reported using new arguments provided for the report variables
peak.nCalpoints and peak.nCalDisabled respectively.

3.7.5 GC-MS Environmental Water Analysis Extension Pack
This release includes a suite of report templates, processing methods and eWorkflows to facilitate
water analysis by GC-MS using EPA methods 524, 525, 8260 and 8270. The extension pack and user
manual may be found in the \Extension Pack\GCMS Environmental Analysis Templates\ folder of the
Chromeleon DVD.

3.7.6 USP Tailing and Width for Riders and Poorly Resolved Peaks [SWFR-2187]
Chromeleon can now provide USP asymmetry or width (at 5%) for poorly resolved or rider peaks. The
feature is only active when enabled in the Advanced Settings of the Processing Method.

3.8 Compliance Features
3.8.1 Global Policy
The following new Global Policies have been added:
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•

Privileged Actions (see 3.10.3)

•

Email Configuration (see 3.10.7)

•

Station Audit (see 3.10.1)

•

Raw Data (see 3.5.2)

3.8.2 User Management Privileges
The following new user privileges have been added:
•

Create Sequence via Save As (see 3.8.6)

•

Create Sequence via Save As with Raw Data (see 3.8.6)

•

Create Sequence from Injection Query Results (see 3.7.1)

•

Manage Privileged Actions (see 3.10.3)

•

Overwrite Standard Comment (see 3.10.3)

•

Manage Maintenance Window (see 3.6.4)

3.8.3 User Management, Admin Console: Session Timeout [SWFR-244]
Chromeleon 7.2 SR5 implements a session timeout for Administration Console, Data Vault Manager,
and Instrument Configuration to increase security of administration functions. When client locking is
active it now affects all client applications.

3.8.4 Capture Logoff in Audit Trail [CM7-21883]
With this release Chromeleon now captures user logoff events from Console and Administration
Console in the user management audit trail. The entry provides time and name of the user logging
off, as well as additional detail when a privileged user closes a locked session or the logoff was
caused by missing licenses.

3.8.5 Additional Detail in Audit Trail Entries [SWFR-1715]
Operations on Data Vault level are now better documented in the data audit trail entries which were
previously only tracked as “changed”. This includes but is not limited to:
•

Changes to access control

•

Changes to or creation of custom variables and custom formulas

•

Data Vault downtime and other settings

•

Change/Move/Create folders.

3.8.6 Sequence Editor: Improvements to ‘Save as’ Privilege [CM7-20486]
Two new Sequences privileges have been added related to the Save As feature. ‘Create Sequence via
Save As’ and ‘Create Sequence via Save As with Raw Data’ are now available, removing the previous
dependencies on the ‘Create Sequence’ and ‘Copy Sequence’ privileges. This effectively prevents a
previous situation where ‘Save As’ was possible without the ‘Copy’ privilege.

3.8.7 Object Version Display in File Listing [SWFR-2214]
The file section in the injection list and any other file listing can now show the version for the objects
listed. Use the context menu of the header to enable the version column.
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3.8.8 Improved Traceability for Sequences after Failed Upload [CM7-20508]
So far sequences that could not be uploaded automatically after a failure were hard to associate with
the original sequence because the information must be searched for in the data audit trail of that
sequence. To make it easier to find those sequences, the Sequence Audit Trail now has an entry
about manual move of the sequence:
14 Remote1_manualmove Sequence 3 10/12/2016 9:31:12 AM -07:00 Autotest Copied From
'chrom://ussvl-sw1601/XVault/USSVL-SW1601_1/19/Remote1.seq’ to 'chrom://ussvlsw1601/ChromeleonLocal/Remote1_manualmove.seq’.
15 Remote1_manualmove Sequence 3 10/12/2016 9:31:13 AM -07:00 Autotest Moved
Automatic upload failed on chrom://ussvl-35f7p12/ChromeleonLocal/Remote1.seq. It has been
manually moved to chrom://ussvl-sw1601/ChromeleonLocal/Remote1_manualmove.seq.
In addition, a notification bar is shown for sequences that have been manually moved.

3.8.9 Logged-on User Name in Administration Console [CM7-21328]
The logged-on user name is now displayed in the status bar of the Chromeleon Administration
Console.

3.8.10 Audit Trail Entries for Print & Export [CM7-7608, CM7-22422]
With this release Chromeleon now generates a data audit trail entry when printing or exporting a
sequence or query report. Printing of an electronic report now also generates a data audit trail entry.

3.9 Time Zone Information
Chromeleon stores timestamps with time offset so that timestamps created in different time zones
can be interpreted correctly. This release includes several improvements in this area.
Note: Features in this section are mostly relevant for large Chromeleon installations which are
spread across different time zones. In this situation data might be acquired in one time zone but
evaluated in another time zone. Single time zone installations with daylight saving time also
benefit due to clear differentiation of time stamps inside and outside daylight saving time. By
storing the time offset with timestamps Chromeleon assists affected customers.

3.9.1 Time zone information for every Time Stamp Display [SWFR-2123, CM720485]
Although previous versions of Chromeleon already displayed the time offset for most time stamps
the time offset was missing from a few places in Chromeleon, for example user management audit
trails. Chromeleon has been updated with time offset where missing.

3.9.2 New Report Category “Time Zone Information” [SWFR-1798]
Report variables for time values now support additional formatting options that can be used in
reporting and custom functions in order to show time offset and to format the time stamp in
universal coordinated time or local time zone.

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3.9.3 Show Information about Time Zone [SWFR-1899]
It can be difficult to interpret the time offset information correctly. This release shows a tooltip for
time stamps, explaining how to interpret the time offset and a comparison of local time vs. originally
recorded time. This is available in the properties dialog, audit trails, injection list, and elsewhere
where time stamps are shown.

3.10 Administrative Features
3.10.1 Audit Trails for System Events [SWFR-2048]
Chromeleon 7.2 SR5 introduces a Station Audit Trail capturing system events such as service startup
and shutdown, sequence start and stop and errors.
The Station Audit Trail can potentially increase the network load and is therefore disabled by default.
To enable the Station Audit Trail go to the Global Policies in The Chromeleon Administration Console.
Similar to other Global Policies it is possible to define this per Organizational Unit.

3.10.2 Administration Console: Additional Audit Trails [SWFR-2025, SWFR-241,
SWFR-1692]
Chromeleon 7.2 SR5 introduces new audit trails for Global Policies, Instrument Configuration,
eWorkflow tags, and Data Vault management.
A combination of all Audit Trails within the Organizational Unit can be viewed using the Audit Trail
node. The events are categorized accordingly.
It is also possible to view the Instrument Configuration and Data Vault Management audit trails for a
specific Chromeleon station in the Chromeleon Domain from the context menu in the list of
Computers, All Resources, Data Vaults, and Instruments respectively in the Domain Resources. The
audit trail for Global Policies can be viewed in the Global Policies editor

3.10.3 Standardized Comments and Authorization for Specific Actions [SWFR-57,
SWFR-1946, SWFR-1947]
Chromeleon 7.2 SR5 introduces standardized comments and authorization for specific actions, so
called Privileged Actions. By providing predefined comments users will save time when commenting
actions, and the comments will be more consistent across different users. The feature is made
available as a new Global Policy and controlled by two new privileges, Manage Privileged Actions and
Overwrite Standard Comment, which are disabled by default. This feature can be enabled per Data
Vault in the Data Vault Properties dialog. It replaces the ‘Comment Required’ feature of previous
releases.

3.10.4 Comments for Administrative Changes [SWFR-2203]
Chromeleon 7.2 SR5 provides an option to require comments on administrative actions. The new
functionality is included in the Privileged Actions.

3.10.5 Schedule Tasks using Local Scheduler [SWFR-943]
The local scheduler of a Chromeleon IPC or Data Vault server can now also be used for scheduler
jobs.
Note: The configuration is only available when logged on locally.
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3.10.6 Extensions to Discovery List [SWFR-1907, SWFR-1901, SWFR-1949, SWFR1908]
The “Domain Resources” node in the Administration Console (formerly known as “Discovery”) now
offers various tables of Chromeleon resources. The lists include significantly more information,
support grouping and filtering, reporting and a variety of context menu tools such as configuring an
instrument remotely.

3.10.7 Notify Admin by Email when Account is Locked [SWFR-1561]
When a user account or signature password gets locked, Chromeleon can now send an email
notification to the administrator. The configuration is available in the as a Global Policy in the
Administration Console.

3.11 User Management
3.11.1 Audit Trail for User Account Cloning [SWFR-2024]
When a new user account is created in the Administration Console using the clone option in
Chromeleon 7.2 SR5, there will be a dedicated record in the user management audit trail. In addition,
further detail about additional changes made to the settings for the new user will be added to the
audit trail entry.

3.11.2 Ability to Set User Account Inactive / Retired [SWFR-1271]
Chromeleon 7.2 SR5 allows administrators to deactivate user accounts for retired users or other
users who are no longer working with the system.

3.11.3 Grouping and Filtering for the User List [SWFR-1272, SWFR-1062]
Chromeleon 7.2 SR5 allows grouping and filtering of user, role and access group tables in the
Administration Console. The filter bar can also be used to search for specific criteria. In addition, the
tables show more detail such as status active/inactive or password expiry.

3.11.4 Default Role for User [SWFR-1909]
Chromeleon 7.2 SR5 allows defining a default role for a user. This role will then be pre-selected for
logon so that users don’t have to think about and pick a specific role on a daily basis.

3.12 Chromeleon 6 Migration
This release further improves data migration and backward compatibility for Chromeleon 6 data.

3.12.1 Chromeleon 6 Data Import in Chromeleon 7 – Signature Data from Signed
Results [SWFR-1130]
When importing signed Chromeleon 6 sequences the eSignatures are now automatically transferred
into Chromeleon 7.

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3.12.2 Direct Import of Chromeleon 6 Backup Archives (*.cmb files) [SWFR-63]
It is now possible to import directly from Chromeleon 6 CMB files. The import allows the user to
select which sequences should be imported in case that several sequences are contained in the CMB.
It is also possible to bulk import more than one file at a time using the File > Import > Bulk Import
menu in the Console.

3.12.3 Querying Chromeleon 6.8 Datasources with Chromeleon 7 [SWFR-507]
Chromeleon 7.2 SR5 can now query injections from mounted Chromeleon 6 Datasources.

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4 Limitations and Known Issues
The following sections list known issues and limitations. The numbers in the first column of the table
below refer to the Thermo Fisher Scientific tracking IDs.

4.1 Limitations with Thermo Scientific Instruments
ID

Description

CM7-16851

UltiMate 3000 MWD-3000 and DAD-3000: In the Instrument Method Editor for these
devices, the script page offers one additional option for the data collection rate (20 Hz)
that is not present in the Instrument Method Wizard. This additional option is a valid
value for this parameter.
Although it is possible to manually type in a value for the data collection rate that is not
in the list, these values will be rejected by the Ready Check when a sequence is
submitted.

CM7-17783

UltiMate 3000 WPS-3000FC: When using the WPS-FC, the needle will not automatically
be flushed prior to collecting first fraction. To work around this limitation, add the
following lines to the instrument method command script:
Sampler.EndFraction
Sampler.Collect
Delay 10
Sampler.Drain

CM7-21342

Vanquish Variable Wavelength Detector: For acquiring data on a single channel only
using the Vanquish VWD it is necessary to use channel UV_VIS_1.

CM6-21321

Accela Open Autosampler: When using this autosampler, a dot (‘.’) must be used as
decimal separator.

CM7-18098

Accela Open Autosampler: Sequences cannot be run when the sampler does not
include the DLW option. This configuration is not supported and requires a custom
script.

CM6-23479

TriPlus RSH: When operating in SPME mode, the TriPlus RSH will schedule samples so as
to overlap oven programs, but it will not optimize based on the various SPME
incubation steps.

CM6-23614

TriPlus RSH: When using the TriPlus RSH in constant double pro headspace mode,
starting a sequence that includes a constant double pro method will generate a
validation error.

CM6-24043

TriPlus RSH: If firmware version 2.2 is installed on the TriPlus RSH autosampler, then
tool changes on the instrument are not immediately recognized in Chromeleon. It is
necessary to disconnect and reconnect the instrument after such changes are made;
they will then be detected.

CM7-21564

TriPlus RSH: Although it is possible to condition the SPME fiber as part of an instrument
method, it is not possible to do so manually.

CM7-20295

TSQ 8000 and ISQ Series: When a GC-MS instrument method includes a scan event
containing multiple SIM ions (e.g. “SIM 115, 152, 188”) then data from matching filters
collected at different time ranges will not be combined into a single filter in the data for
that injection.

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ID

Description

CM7-15632

TSQ Quantiva and Endura: When removing the source from a TSQ Quantiva or Endura
in mid-acquisition, the sequence does not abort.

CM7-16030

TSQ Quantiva and Endura: With these instruments the standby state reports that the
instrument is on, regardless of the real instrument state.

CM7-16154

TSQ Quantiva and Endura: When creating an Instrument Method for the TSQ Endura or
TSQ Quantiva, the MS run time is not the same as the Chromeleon run time. The user
should enter the correct run time on the MS page of the Wizard.

CM7-17668

TSQ Quantiva and Endura: TSQ Endura and TSQ Quantiva instruments are usually
shipped with a PC (“Endura/Quantiva PC”) that includes all the necessary instrument
data files, such as calibration files, for operating the MS instrument. If you want to
control an instrument using a different PC, make sure that the specific instrument data
files residing on the Endura or Quantiva PC are backed up and transferred to the new
PC. For details on performing this process, please consult with your local MS field
service engineer.

CM7-17500

Exactive Series: Exactive Series instruments are usually shipped with a PC (“Exactive
PC”) that includes all the necessary instrument data files, such as calibration files, for
operating the instrument. If you want to control an Exactive instrument using a
different PC, make sure that the specific instrument data files residing on the Exactive
PC are backed up and transferred to the new PC. For details on performing the data
backup on the Exactive PC, refer to the Thermo Exactive Series 2.5 SP1 Release Notes,
section Backup provided on the Chromeleon installation disk in the Packages\Thermo
Exactive\Documentation folder.

CM7-16557

MSQ Plus and Tune Application: When using the MSQ Plus with Chromeleon the user
has to wait for the Chromeleon Instrument Controller to be in idle mode before
opening the Tune application. Without waiting, the MSQ Plus will not be able to change
the operating mode (On, Off, Standby), or it will not be possible to run injections. To
recover from this error both the PC and the MSQ Plus would have to be restarted.

CM7-18129

TSQ Quantiva and Endura: After an upgrade of the TSQ Endura/Quantiva instrument
driver, an error may occur when opening the Chromeleon Instrument Configuration. To
resolve the error, remove the Chromeleon Mass Spectrometer driver from the
configuration and then add it again. This will update the configuration information in
Chromeleon to match the updated TSQ Endura/Quantiva instrument driver version.

CM7-21967

TSQ Quantiva and Endura: The TSQ Endura and Quantiva mass spectrometer method
editor is supported on English operating systems with English/United States regional
settings only.

CM7-22490

Exactive Series: When setting the divert valve parameters for an Exactive Series MS
with a 2-position valve, the valve positions are recorded in the MS raw data opposite of
how the divert valve parameters were configured.

CM7-23138

MSQ Plus: It is recommended to use only the MS driver provided on the Chromeleon
installation medium. Other versions of the MSQ Plus driver may not be compatible with
Chromeleon. Please consult your local field service engineer for additional details.

CM7-23295

Exactive Series: Due to differences in how the Exactive 2.8 SP1 driver writes the scan
header in MS data files during acquisition, non-targeted peak detection will not work
correctly when data generated from both the Exactive 2.8 SP1 driver and older drivers
are present in the same sequence.

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4.1.1 Compatibility of Chromeleon 7.2 SR5 and SII for Xcalibur
At current time, SII for Xcalibur (SII) has not been validated for use with Chromeleon 7.2 SR5. As such
any installation combining SII with Chromeleon 7.2 SR5 is not supported. At a time when SII is
compatible with this release, documentation outlining support will be released which will supersede
this known limitation.

4.1.2 Mass Spectrometers and Windows 10
Thermo Scientific Foundation 3.0 SP2 is required for mass spectrometer support under Chromeleon.
As Foundation 3.0 SP2 is not compatible with Windows 10, no mass spectrometers are supported
under Windows 10 at this point in time.

4.1.3 Compatibility with Foundation 3.1
Chromeleon is only compatible with Thermo Foundation 3.0 SP2. Users may encounter situations
where PCs provided with mass spectrometers come pre-installed with Foundation 3.1 or newer. In
these instances, the factory procedure to uninstall any MS instrument control component software
must first be followed before reinstalling Foundation 3.0 SP2 and the mass spectrometer driver.
This procedure must only be carried out by individuals that have completed the necessary software
and hardware training.

4.2 Limitations with the Waters Driver Pack
ID

Description

CM6-21040

Waters Acquity: Should a Waters instrument detect an IP address conflict during start
up, the Chromeleon CDS driver will log the error message in the Audit Trail. If this
message is ignored, it will be displayed again after 2 hours, which can result in a running
sample being aborted.

CM6-21112

Waters 2998 PDA: Localization to a non-English regional setting for the PC (e.g.,
German) does not function correctly for the timed events table, e.g., using a Waters
2998 PDA detector and setting a timed event in the program file (e.g., wavelength
change at 5 minutes). The event is recorded, but without the event time.

CM6-24158

Waters 2489 PDA: After changing the Instrument Method from single to dualwavelength mode (without changing Channel A wavelength), the data rate for Channel
B is set incorrectly and incomplete data collection occurs.

CM6-23194

Waters Acquity: After removing the Sample Organizer from the Instrument
Configuration, the plate setup is not updated correctly. Manually updating the plate
settings in the plate setup configuration dialog avoids this issue. If the total length of
the instrument name plus detector name is more than 32 characters, the sequence will
abort shortly after initial injection. The affected detectors are: 2489, 2998, and Acquity
FLR.

CM7-19830

Waters Acquity: When using the Waters Acquity driver in a Citrix environment, the
Acquity console does not update correctly and therefore doesn't show current log file
entries. This is due to a problem in the Acquity console, and can be mitigated by using
the instrument audit trail on remote clients.

CM7-22872

Waters Acquity: When using the Waters Acquity driver, some Chromeleon screens may
not appear properly, such that text from the previous screen is still visible. This has
been observed with the Sequence Properties and the Chromeleon Log on screen.

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4.3 Limitations with Agilent ICF
For a general overview regarding the Agilent Instrument Control Framework, please refer to the
document Chromeleon and Agilent ICF - Quick Start Guide - Chromeleon 7.2 .pdf, found in the
\Documents\ folder of the Chromeleon 7.2 CDS DVD.
ID

Description

CM7-19347

Agilent G1312B DAD: When using a G1312B DAD in combination with an old JetDirect
card, the user may experience problems collecting data at 80Hz. If the user observes
this, they should get in touch with their local Thermo Fisher Scientific representative for
advice on possible solutions.

CM7-20047

Agilent VWD G1314B: When using a G1314B VWD, occasionally the chromatogram is
half the expected length.

CM7-20991

Agilent ICF: Occasionally when performing injections with ICF controlled instruments
the injection volume is incorrectly displayed, although the injection itself was
performed correctly.

CM7-21172

Agilent ICF: If the user has the monitor DPI settings on their PC set at greater than
100%, then some parts of the Agilent LC system device ePanel are not visible.

CM7-23096

Agilent ICF: If a Fraction Collector with Thermostat is installed, the channel mapping is
not correct. This can be resolved by removing the 
node from DefaultConfiguration.xml before adding the driver. After this, the user can
configure the mapping for the two channels manually on the Signals (2D) tab of the
configuration dialog.

CM7-19540

Agilent ICF: The Agilent GC System Configuration dialog includes entries to configure
the 7697A Headspace, G1888A Headspace, 7890 GC, 6890 GC, 68550 GC, and 7820 GC.
Currently, it is only possible to configure the 7697A Headspace sampler. Attempting to
configure any of the other modules will result in a message indicating that the modules
are not supported.

CM7-19863

Agilent ICF: The Agilent LC System Configuration dialog includes entries to configure the
following devices, which are not supported by the release:
All ELS Detectors (Drivers are not included, so they cannot be configured)
Multi-sampler and DAD HDR (Although configurable, they have several known issues
and are therefore not supported)

CM7-21427,
CM7-18984

Agilent ICF with 1100 or 1200 LC DAD: When acquiring data from an Agilent 1100 or
1200 LC DAD, the signal trace may be shifted to the start of the run, and the end time is
inconsistent. No data points are lost with a data rate of
10 Hz and slower (>= 0.025 min 0.5 sec)
20 Hz and a low number of spectra (all other than ALL Spectra)
20 Hz and spectrum range 190- 400 step 2

CM6-23980

Agilent 7697A: When starting a sequence while the 7697A Headspace Sampler is in an
‘Error’, ‘Running’, or ‘Not Connected’ state, the ready check does not give an error
message. After the sequence starts, the following happens:
If the sampler is in error state, the sequence starts without getting interrupted
If the sampler is running, the sequence stops with audit trail message “Sequence
stopped by user”
If the sampler is not connected, the sequence interrupts with audit trail messages “Lost
connection to Agilent 7697A Headspace Sampler", and "The instrument is offline. Check
power to all modules, cabling between modules and whether the configuration
matches the list of modules."

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ID

Description

CM6-23992

Agilent 7697A: The 7697 Headspace Sampler has two versions; 111- and 12-vial
capacity configurations. The Chromeleon driver is written and tested with the 111 vial
capacity version. Though not tested, the driver is expected to work with the 12-vial
capacity module. The user should not use vial positions greater than 12 in this case. The
rack view always shows 111 vial positions.

CM6-24004

Agilent 7697A: Using the instrument front panel, the allowed range for Transfer Line
Diameter is 200-600 microns. However, when setting this value in the Chromeleon
instrument configuration the limit is 250-530 microns.

CM6-24005

Agilent 7697A: When 7697A headspace instrument method parameters are included in
a report, the “fill pressure” parameter is rounded to the nearest integer.

CM6-24007

Agilent 7697A: Some parameters logged to the instrument audit trail are rounded to
nearest integer. However, all values are downloaded to the instrument with the proper
precision.

CM6-24008

Agilent 7697A: When editing an existing 7697A Headspace instrument method, if the
values for Purge Flow, Purge Time or Leak Flow are changed, the Save button is not
enabled until the user changes tabs.

CM6-24009

Agilent 7697A: When configuring an Agilent 7697A, there is an option in the user
interface to “Upload Config from Instrument”. This option does not work. Instead, you
will need to manually configure the instrument settings.

CM6-23996,
CM7-19940,

Agilent 7697A: The 7697 Headspace Autosampler has two options for handling missing
vials: Pause and Abort. An issue has been observed when the Abort option has been
selected. In either mode, the autosampler overlaps sample preparation, i.e.: sample 2
is prepared while sample 1 is acquiring. If the autosampler finds that the sample 1 vial
is missing, it will Abort or Pause the sequence at the point it discovers the vial is
missing. However, if the autosampler finds that the sample 2 vial is missing, while
sample 1 is already acquiring, and the Abort option has been selected, the entire
sequence will be aborted, including the acquiring sample 1.

CM7-21324

CM7-19975,
CM7-20451

Agilent 7697A: The Soft Config option, available via the ICF for Agilent LCs, is not
supported for the Agilent 7697 HS. It should not be added to any custom ePanel as its
use can cause issues by allowing configuration changes to be applied to the sampler
during acquisition.

CM7-19993

Agilent 7697A: If the 7697A loses its connection to the network, an audit trail message
is added indicating this fact. However, the ePanel will still show the unit as ‘Ready’.

CM7-20259

Agilent 7697A: Although the vial position may be assigned in the instrument method
script, unless this is done in the Instrument Setup Stage, the sequence table will not be
updated. This can result in misleading information in reports and should be avoided.

CM7-23242

Agilent 7697A: Running multiple 7697A Headspace autosamplers on a single 247
Instrument Controller can cause Windows "Out Of Memory" errors, requiring a reboot
of the 247 to resolve. Thermo Fisher therefore recommends that only one 7697A is
connected to any 247 Instrument Controller.

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4.4 Limitations with Other Third Party Instruments
ID

Description

CM7-17948

Shimadzu LC: Unlike most drivers, some Shimadzu UV detectors require that you select
the Advanced filter in the Command (F8) window in order to access the Lamp On/Off
command.

CM6-23947

Shimadzu LC-10A, LC-2010: If the user cancels the keylock state of the front panel of the
instrument and then, for example, stops a manual acquisition, this is likely to lead to
unexpected effects during the next operation such as sudden abort of the sample run.

CM7-15400,
CM7-15556,
CM7-15734,
CM7-15736

Perkin Elmer LC200 Autosampler: When upgrading from earlier versions of Chromeleon
7 CDS to Chromeleon 7.2 CDS SR3, it is necessary to reload the Perkin Elmer LC200
Autosampler driver and configure the loop size within the configuration. The user
should then check all instrument methods using this autosampler to ensure that they
continue to function correctly.

CM7-15716

PerkinElmer Clarus 400 GC: Some users must select Autosystem XL in configuration in
order to communicate with the PerkinElmer Clarus™ 400.

CM7-20464

Varian 3800 GC: It is not possible to start a manual data acquisition if the GC is not
ready (i.e. all temperatures, pressures and so on are at their set points). Trying to do so
will generate a Ready Check message detailing what is not ready.

CM7-12366

Agilent 5890 DICE Card: Please note the following when using the19257 DICE card with
the Agilent 5890 GC:
Control and acquisition using the DICE card is only supported via the serial interface.
The GPIB interface is not supported.
Digital data acquisition via the serial interface of the DICE card is only supported for a
single channel; dual channel digital acquisition is not supported.
Currently, it is possible to select certain illegal combinations in the Configuration Dialog
such as:
Digital acquisition with the 19254 card. This is not supported.
Digital acquisition on one detector and analog acquisition on the other. Acquisition
needs to be exclusively digital or exclusively analog.
When using the DICE card to acquire data digitally, the 5890 INET mode must be set to
“GLOBAL” not “LOCAL”. Failure to do so will result in a “No response from GC” message
following the AcqOn command in the audit trail.
Note that when performing analog acquisition, the 5890 INET mode should still be set
to “LOCAL” (as described in the online help).

CM7-9675

Agilent 7890 GC: There is a backward compatibility issue that affects the Agilent 7890
GC Sampler Positions. When using a 7890 GC in combination with a 7693 sampler,
certain positions in the sampler could give a misspelled value to a move command. This
has now been corrected and could in rare cases lead to Instrument Method files
needing to be updated to avoid errors.

CM7-15293,
CM7-18463

Agilent 1100 Obsolete Driver: Occasionally, when using a combination of older and
newer modules, the raw data was not correctly acquired.

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4.5 Other Limitations
ID

Description

SWFR-2543

Sampling Devices That Do Not Use uL As Units for Volume: Although most liquid
injection devices expect volumes to be entered in uL, there are a few devices (e.g.
Thermo AS-HV and Perkin-Elmer GC Autosampler) which do not use µL as their default
volume unit. If one of these devices is configured in the same instrument that also
includes an injection device that uses µL, problems may be observed with volume
validation in the sequence table as well as units associated with volumes in reports.

CM7-21780

NIST MS Search and Demo Library No Longer Automatically Installed: Incompatibilities
of the NIST 2008 MS Demo Library installer with Window 7 and 10 could cause the main
Chromeleon installer to hang or crash. To address this, the NIST Demo library, and the
associated AMDIS and MS Search software are no longer automatically installed when
you install Chromeleon. If desired, this package may be installed manually using the
setup program found in the /Tools/ folder of the Chromeleon DVD. Alternatively, one
may install AMDIS and MS Search using the full (licensed) NIST library installer.
Note that MS library searching within the Chromatography Studio is not affected by this
issue.

CM7-20335

Comparison of Old Report Versions Shows Change in CmbxExportParameters: If a
report which was created in CM 7.2 SR2 or earlier, and modified in SR3, has its history
compared in SR4, the history will appear to show that the "Cmbx Export Parameters"
value has changed from True to False. This is due to a change in the default value of
this field, and does not represent any user-modification of the report.

CM7-20449

User Management: Login "Role" dropdown box becomes empty after upgrading to
Chromeleon 7.2 SR4. This is due to the fix for CM7-18178 "Roles were offered in the
Logon dialogue, even if they were not specified as Logon roles". To work around this
issue, enable the "Logon Role" property in the user database for all logon roles that
users need to be able to select.

CM7-21783

Performance When Importing Fixed Calibration Standards for MS Sequences: When
working with sequences of MS data, importing injections for use in a fixed calibration
can take 1-2 minutes to complete, depending on the data.

CM7-17203

Report Designer: With some date/time formatting settings in the report, the order of
month and day changes for some formats automatically. The settings in the Report
Template can change based on the windows regional settings. For example it is not
possible to set m.d.yy as format with German regional settings. The Report Template
replaces this with d.m.yyyy. The substitution occurs for report variables and non-report
variable entries.

CM7-17841

Report Designer: If using a non-Chinese format as the regional setting in Windows, and
Chinese as the setting for Non-Unicode programs, then the header on a Chromeleon
report is not correctly displayed for variables. If the format is changed to Chinese, then
everything is correctly displayed.

CM6-23886

Exception Error When Removing USB->COM Port Adapter: If a USB-to-RS232 adapter is
used to provide COM communication between an Instrument PC or 247 Instrument
Controller and an instrument, and the USB connection is unplugged, Chromeleon
reports a Fatal Error in the Instrument Audit trail. The USB-to-RS232 adapter should not
be disconnected from the Instrument PC or 247 Instrument Controller while it is
powered-on.

CM7-18252

Export MS Raw Data: When acquiring MS data, Chromeleon acquires MS data and all
other signal data, such as UV, FLD, and pump pressure signals, in separate formats. As a
result, when MS data is exported, non-MS data is not exported with the MS raw data
file.

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ID

Description

CM7-19336

Chromeleon 6 Import: Due to changes in Auditing between Chromeleon 6 and
Chromeleon 7, when a Chromeleon 6 Sequence is imported into Chromeleon 7, some of
the text displayed in the Instrument Audit trail will not appear exactly as it did in
Chromeleon 6. Refer to the topic "Viewing Chromeleon 6 Data" in the online help for
further information.

CM7-21331

Report Variable chm.massSpectrum("...").resolution always shows "0,5000": The mass
spectrum resolution report variable returns an internally used processing value instead
of the resolution setting defined in the MS instrument method. It is recommended to
discontinue use of this report variable until further notice.

CM7-21399

Injection Variables 'Auto Dilution Ratio' and 'Retention Time Standard': Auto Dilution
Ratio and Retention Time Standard columns are not available in the custom filter
conditions for injection records (e.g., in the IRC editor or summary report).

CM7-22111

Mixed Installations with Chromeleon 7.2 SR5 Domain Controller: If you have an existing
installation of Chromeleon < 7.2 SR1, the following limitations apply during an upgrade:
Stations that have Chromeleon 7.2 or below installed will not see any data vaults or
instruments that have been created with Chromeleon 7.2 SR5, until after those stations
are upgraded to 7.2 SR5.
It is not possible for a Chromeleon 7.2 (and below) station to join a Chromeleon 7.2 SR5
domain.
Stations that have Chromeleon 7.2 or below will not receive any updates from the
Discovery Service after the Chromeleon domain controller has been upgraded to 7.2
SR5, and will only see resources that were already in existence and cached.
Please refer to the Enterprise Documentation for guidance on upgrading an older
installation of Chromeleon 7 to Chromeleon 7.2 SR5.

CM7-22145

Discrepancy in “Last Modified” Time: Owing to differing rounding methods used, it is
possible that the value of the "last modified" time for an object in a sequence has a
difference of 1 second between the client display and the value shown in a report. For
more details, please see the on-line help.

CM7-20637

Logon with Current Windows Account after Disconnecting Network Fails with
Misleading Error Message: In the event of a loss of network connection on a system
using LDAP logon, attempting to logon to Chromeleon again with the same account
details results in a misleading error message "The user name or password are
incorrect."

CM7-23033

Legacy Upload: With replication framework disabled, when trying to modify a sequence
while the automatic upload is already in progress the upload may fail in very rare cases
and it is not possible to remove the sequence from the instrument queue by retry of
the upload. To recover the sequence a copy of the sequence has to be stored manually.
Chromeleon 7.2 SR5 adds an audit trail entry to the manually uploaded sequence that
refers to the original sequence so that traceability is ensured.
Thermo Fisher Scientific recommends to enable the replication framework with
Chromeleon 7.2 SR5 to avoid the problem.

CM7-23481

Fatal Error in Chromeleon 7 Real Time Kernel Service: When leaving the Instrument
Configuration Manager open over extended periods of time the Chromeleon Real Time
Kernel Service might stop unexpectedly with a fatal error in the Windows Event Log.

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4.6 Obsolete Drivers
Chromeleon includes a number of obsolete drivers in order to provide backward compatibility of
existing installations:
•

Agilent/HP 1200 HPLC System

•

AI 1310/3000 GC Sampler - 10ul

•

AI 1310/3000 GC Sampler - 5ul

•

AI 1310/3000 GC Sampler - 5ul - 155 Vials

•

AI 1310/3000 GC Sampler - 5ul - 105 Vials

•

AI 1310/3000 GC Sampler - 10ul - 155 Vials

•

AI 1310/3000 GC Sampler - 10ul - 105 Vials

•

PAL Sampler for GC

•

PAL Sampler for LC

•

TRACE 1300 Series GC (First generation driver that has been superseded by TRACE 1300 Series GC
II driver)

Please note that issues reported for any of these drivers will no longer be addressed. If you are using
one of these drivers Thermo Fisher Scientific recommends migrating to a supported driver as soon as
possible.

4.7 Defects Under Investigation
The following defects have only occurred very rarely, and data necessary for investigation, such as
log files and backups, are insufficient to reproduce the problem. Despite significant testing efforts in
various configurations we could not reproduce this behavior in systems that are set up and
configured as recommended by Thermo Fisher. Thermo Fisher is therefore unable to identify the root
cause of the problem and provide technical modifications of the software that would allow us to
confidently state that we prevent future incidents of such behavior. We are continuing investigation
of these issues but would like to share symptoms of this behavior with our customer base and give
recommendations to remediate from the behavior if it occurs.
Note: If you are affected by any of these defects, please collect a System Status Report
immediately and contact your local Thermo Fisher representative for further assistance.

4.7.1 Empty Inject Time and GUID Fields in the Injection Record [CM7-22738]
Empty Inject Time and GUID fields have been seen in a few single injections. Raw data have been
successfully acquired and stored on the local Instrument PC. The Injection Audit Trail on the
Instrument PC contains complete information, including the missing details. Too few instances have
been reported to identify the root cause of this problem.
Note: If you are affected by this problem, please contact your local Thermo Fisher representative
for assistance with recovery of the missing injection details.

4.7.2 Instrument Audit Trails Are not Properly Saved/Written on the local Data
Vault [CM7-23051]
In one installation, a few Sequences aborted with the following error messages in the audit trail:

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“The audit trail was unavailable for some time. Several audit trail messages are lost. They have been
logged to the file "Dionex\Chromeleon\Log\AuditTrailMessages.log" in the (common) application
data folder.”
During investigation of the log files of affected Instrument Controller PCs errors of slow file
operations on the local hard drive have been found:
“SQL Server has encountered 1 occurrence(s) of I/O requests taking longer than 15 seconds to
complete on file [C:\ProgramData\Dionex\Chromeleon\DataVaults\XVault\XVault_log.LDF] in
database [XVault] (6)“
It has been confirmed that the failure was caused by poor disk drive performance and only occurred
over a limited period of time. Chromeleon 7.2 SR5 introduces additional error handling and reporting
so that similar errors can be identified more easily.

4.8 Functional Differences between Chromeleon 7.2 and Chromeleon
6.8
Chromeleon 7.2 SR5 implements the vast majority of Chromeleon 6.8 features, and in general, has a
richer feature set than Chromeleon 6.8. However, a few Chromeleon 6.8 features remain to be
implemented on the Chromeleon 7 platform and a few will never be implemented, since they are
now obsolete or no longer relevant. If a particular missing feature is important to you, please
contact your local Thermo Fisher Scientific representative to find out if that feature is in the product
development plans.

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5 Resolved Issues
This chapter describes the issues that have been resolved with the release of Chromeleon 7.2 SR5.
Many trivial and minor issues have been resolved, but are not mentioned here. If you require
information about the status of an issue observed in a Chromeleon 7 release, but which is not listed
here, please contact your local Thermo Fisher Scientific representative for more information.
The numbers in the first column of the table below refer to the Thermo Fisher Scientific tracking IDs.
ID

Description

CM6-23310

Corona Veo: The range for the Signal Calibration Factor was incorrect. The range has
now been corrected to 0.800 - 1.200.

CM6-23362

Shimadzu GC-2014: The injection time out was a fixed value, resulting in an abort
message if an injection took more than five minutes to occur. A time out parameter was
added to the method user interface to address this.

CM6-23589

Shimadzu GC-2010/2014: If the pressure unit was set to psi, never-the-less values were
sent to the instrument in kPa.

CM6-23854

A2D: Entering invalid characters (any character other than A-Z, a-z, 0-9 or _) into the
A2D name field, and then pressing  would cause a 'Fatal error' to be displayed.

CM6-23859

A2D: When a Stop Flow / Hold command was performed, instead of displaying the time
at which the Stop Flow / Hold command was performed, the A2D LCD screen incorrectly
reset the time to 0.0.

CM6-23871

TRACE GC Ultra: If an instrument method with an isothermal part at the beginning was
used for a sample type blank, the isothermal section was ignored.

CM6-23876

A2D: If the A2D was connected to an Autosampler which only provided a very short
Inject signal (e.g. Agilent HPLC), the A2D could 'miss' the signal and remain at Wait
Inject. If the A2D then captured the Inject signal of the next injection, the Chromeleon
sequence could become 'out of synch'.

CM6-23880

A2D: Occasionally, when pressing the < or > (left or right) buttons on the A2D, the LCD
would appear to 'skip' one screen.

CM6-23952

TRACE 1300 GC II: The driver attempted to connect to port 2551, although this had
been changed on the driver properties page to port 4900. This led to an error message.

CM6-23977

Shimadzu GC-2010/2014: Chromatograms collected from a Shimadzu GC-2010/2014
were saved with units of ‘Absorbance’, resulting in an incorrect Y-Axis label in reports.

CM6-24026

TRACE 1300 GC: The ‘Peak Width’ instrument method parameter was not properly
applying digital filtering in the detector hardware. This resulted in the observed noise in
chromatograms with a low concentration of sample being higher than the hardware
specification.

CM6-24028

Perkin Elmer GC: If using the output detector type to collect data from unsupported
detectors, the driver would reject the connection.

CM6-24037

Agilent 6890 GC with 7693 AS: A sequence could abort with an "Error in injection
setpoints" message if the instrument method contained invalid Solvent Saver settings,
even if the settings were not used. This occurred because it was possible to download
unsupported settings from the hardware during the creation of an instrument method.

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ID

Description

CM6-24044

Shimadzu LC-2010: In very rare circumstances it was possible for the CDX module to
start in simulation mode after an Instrument Controller start, leading to the
Chromatogram being recorded using demo data. This was visible form the different
data rate compared with that expected, leading to a stretched RT axis.

CM6-24051

Agilent 7697A HS: Disconnecting the sampler while a sequence was running would
cause a long series of audit trail messages, requiring the instrument controller to be
restarted in order to recover

CM6-24114

Waters Acquity: The acquired signal of the pressure channel would show bar as the
unit, regardless of the settings in the configuration.

CM6-24115

Agilent LC (ICF): Repeatedly changing the instrument configuration parameters could
result in an "LC System returned an invalid configuration! Default configuration is used
instead" error.

CM6-24122

Agilent 7890 GC: When a Cryogenic Oven Cooler was configured, the minimum oven
temperature was not properly saved, and attempting to manually update it resulted in
an exception error.

CM7-3687

Chromeleon 6 Import: When importing certain reports from Chromeleon 6 corrupt view
settings were created, causing an 'Error - Invalid argument' to be displayed in the
Studio.

CM7-10662

Console - Sequence Editor: When copying and pasting table data into the sequence
editor, selection of the same number of cells as the source table was required. The
behavior has been changed so that only selection of the first cell for correct pasting is
required.

CM7-11571

Data Vault Manager: In certain circumstances it was possible that a user might mount a
Data Vault and not be aware that it was already mounted on another Data Vault server.
Improvements have been made so that the user is now notified and in addition the data
audit trail information has been improved when mounting and dismounting data vaults.

CM7-12682

Console - Custom Variables Manager: The Finish button was always enabled, even if no
variable was selected in the grid. The button is now disabled until a variable has been
selected.

CM7-13611

Console - Data: Clicking on the [+] button to expand a Remote Data Vault could cause
Chromeleon to become unresponsive if the Remote Data Vault was not available or was
still in the process of connecting.

CM7-13761

Studio - Report Designer: Formulas on the Time and Signal Axis properties pages in the
chromatogram object weren’t applied correctly when using German regional settings

CM7-14193

Studio - Processing Method: When the Calibration type was set to Polynomial, the
Order dropdown list would only accept a value of 1, instead of the range of values 1 - 7.

CM7-14244

ICS-3000/ICS-5000 EG: Entering upper limit value (e.g., 50 mM) in Instrument Method,
then viewing Smart Startup would throw "concentration out of range" errors, even
though the permitted range was 0 to 50 mM.

CM7-14636

Console - Custom Variables Manager: Custom Variables containing spaces cannot be
used in Instrument Methods. However, if a Custom Variable was created which
contained a space, Chromeleon gave no warning or indication that this could result in
an issue if it was subsequently used in an Instrument Method. Chromeleon now shows
a tooltip to warn the user.

CM7-15119

Sequence Editor - Custom Variable Wizard: Even if a sequence was set to read-only
mode, it was possible to run the custom variable wizard to create a new custom
variable. However, it was not possible to save the custom variable created in this
manner afterwards.

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ID

Description

CM7-15150

eWorkflows: Under certain uncommon situations, an individual user wasn't able to see
any available eWorkflows available, even though other users were unaffected.

CM7-15539

Studio - Processing Method: Trailing spaces after component names or unidentified
peak groups were allowed, resulting in identical looking components and unidentified
peak groups being treated separately, such as "Component1" versus "Component1 ".

CM7-15993

Services: During an upgrade the account under which the Data Vault service or
Scheduler service is run would be reset to Local System. If either service is set to run
under a different user account, this is now preserved during an upgrade.

CM7-16146

Services - Discovery: Following an unexpected reboot, after a power-outage for
example, the Discovery Service could sometimes fail to start correctly.

CM7-16378

Reporting - MS Spectrum Plot: It was not possible to select a component to plot based
on a peak name when the MS quantitation channel was selected.

CM7-16454

Console - Custom Variables Manager: Chromeleon Custom Variables Manager would
incorrectly allow the re-selection of already-imported Custom Variables, and would
then report an error "The Custom Variable name is already in use" when it attempted
to import these variables.

CM7-16526

Agilent 7890 GC: Column ePanel did not properly report the actual pressure value from
the instrument

CM7-16691

Console - Sequence Editor: It was not possible to use the sequence editor fill-down
function when the table was filtered.

CM7-16746

Audit Trails: Printing very large instrument or injection audit trails would generate a
‘Parameter Not Valid’ exception error.

CM7-16942

Instrument Configuration Manager: When two users both tried to modify the
configuration of the same instrument at the same time, misleading error messages
were generated. The error messages incorrectly claimed that the user needed to login
in order to change the configuration.

CM7-17073

Administration Console - Scheduler: Optimizations have been applied to improve the
performance when importing Chromeleon 6 data to a Chromeleon 7 Data Vault.

CM7-17156

Data Vault Manager: Attempting to dismount a Data Vault with a name written in a leftto-right script could sometimes fail to dismount, with inaccurate error messages raised.

CM7-17186

Instrument Configuration Manager: After making changes in the Instrument
Configuration Manager, if you exited and selected “Don’t Save”, then if you reopened
the Instrument Configuration Manager, the changes still appeared. Although the
changes were actually discarded, unless the instrument controller service was
restarted, the changes still appeared in the Instrument Configuration Manager user
interface.

CM7-17273

Console - Sequence Editor: Attempting to run a sequence where a numeric field (such
as Weight”, Dilution” or “IntStd”) for an injection was empty resulted in a "Nullable
object must have a value" error message.

CM7-17328

Reporting: If the user attempted to view a Chromeleon 6 diagnostic report directly in
the Chromeleon 6 datasource, the results were not reported correctly.

CM7-17352

Services - Discovery: If the Console was left open while adding new Data Vaults in the
Data Vault Manager, the new Data Vaults would not immediately appear in the
Console.

CM7-17365

Setup and IQ: Installation of Chromeleon Help would not be performed if the Help file
was open while the installation was running. This would then cause the IQ to fail due to
the help having not being updated.

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ID

Description

CM7-17496

Studio - Data Processing: Creating extracted ion chromatograms in some instances did
not generate a permanent channel. The functionality has been improved in various
locations to allow for creation of permanent channels based on user enablement of the
functionality.

CM7-17610

Administration Console - Discovery: Applying a new Chromeleon Domain name while
multiple other Chromeleon application are running causes a warning message, which
lists all the running Chromeleon applications, to be displayed. If the Domain name
change is retried, with one (or more) of the other Chromeleon applications still running,
the warning message should now only contain the remaining open applications, not the
original full list.

CM7-17674

ePanel - Exactive Series: Depending on the order in which the Exactive Series driver and
Chromeleon are installed, the button to launch the Tune application in the ePanel did
not work.

CM7-17689

Client - General: In some circumstances, opening a Report from one Sequence while
already editing a Report in a different Sequence could cause an unhandled exception in
Chromeleon.

CM7-17705

UltiMate Drivers - Fraction Collection: If using fraction collection by time, the last tube
was not handled correctly, resulting in an aborted sequence. This would then prevent
any further injections or sequences from starting even if enough tubes were available.

CM7-17820

Console - Injection Query: Imported sequences which have not yet been converted for
processing in Chromeleon could not be queried. A seq.imported report variable has
been added which, when set to "true", allows for query of imported sequences.

CM7-17842

Reporting: Foreign characters in report headers and footers in some instances did not
correctly export to Microsoft Excel format.

CM7-17870

ICS-4000: Region-specific decimal syntax would throw a "value out of range" error for
certain controls. Occurred when using a comma (e.g., 4,567) in an OS environment
where commas represent a decimal point.

CM7-17894

Setup: If the username of the administrator performing the installation contained
invalid XML characters such as ‘&’, the installation would fail. These usernames are now
supported.

CM7-17930

Administration Console - Scheduler: Setting up a scheduler task including a Chromeleon
6 query, would sometimes force the user to enter credentials.

CM7-17931

Administration Console - Scheduler: Running a scheduled task involving a Chromeleon 6
query of a Chromeleon 6 datasource, with the Chromeleon 6 user mode disabled,
resulted in the task failing due to "ERROR - Access is denied". The scheduled task will
now complete successfully even when the Chromeleon 6 user mode is disabled.

CM7-17937

Administration Console - Scheduler: The Browse dialog box did not always appear in the
visible area of the screen when selecting a CM6 Query.

CM7-17938

Console - Import/Export: CMBX Export of large sequences would sometimes fail with an
'Out of memory' error.

CM7-17939

Administration Console - Scheduler: After changing the service account under which the
Scheduler was set to run the service did not restart and had to be started manually via
the Windows Services dialog. The Scheduler service now restarts as expected after
changing the service account.

CM7-18073

Services - Discovery: The Domain Controller could get into a situation where it was
running, but would no longer accept the addition of any further Workstations without
being restarted.

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ID

Description

CM7-18083

Setup and IQ: The Chromeleon installation would sometimes 'hang' during installation,
due to an unhandled issue in the NIST installation package. Installation of NIST has
therefore been removed from the Chromeleon installation, and should be installed
separately using the installation kit provided on the Chromeleon 7.2 SR5 DVD.

CM7-18208

IQ/OQ/PQ: The signature fields in the report templates for Chromeleon OQ, and
Instrument IQ/OQ/PQ were not in the same order in which they were signed.

CM7-18321

Console - Version Comparison: When a Calibration Level was renamed, the Comparison
Report showed this action as separate Delete and Add actions, instead of a single
Rename action.

CM7-18322

TRACE 1300 GC: When running long sequences, the sequence would potentially hang
before the start of acquisition for an injection. The fix for this issue involved software as
well as upgrading to GC firmware package 28 or higher.

CM7-18326

Console: Two custom variables with the same name could be created, which could
prevent connection to a data vault that contained one or more of the identically named
variables.

CM7-18352

UltiMate Drivers - Fraction Collection: When using the "collect outside peaks" option
during "collect by peak," the option would only start after the first peak had been
collected.

CM7-18356

Administration Console - Global Policies: On a system with multiple Organizational
Units, and different Multi-User Logon policy settings for each Organizational Unit, the
Multi-User Logon policy of the first logged-on user was applied, instead of the policy for
the Organizational Unit to which the computer belongs. If these were different, then
the policy could be applied incorrectly.

CM7-18368

Studio - Processing Method: When copying an item into a table (e.g. a component
name into a component table) it was not possible to select several cells and paste into
them all simultaneously.

CM7-18391

Electronic Signatures: In certain circumstances it was possible that Signature
Verification of a sequence that was signed using a Chromeleon version less than but not
including 7.2 could fail if the verification was done using a later release. The issue that
caused the signature verification to fail has been resolved.

CM7-18406

AFC-3000: If using fraction collection by time, one more tube than necessary was used.

CM7-18567

Client - General: If the client was locked while the Performance Qualification was
running, it was not possible to unlock the client until the qualification had finished. The
Unlock Client dialog now asks for initial user to re-logon instead of the Qualification
user.

CM7-18645

Data Vault Manager: Renaming a Data Vault to contain certain characters (e.g. "µ")
would result in an inaccurate error message, and could result in the Data Vault
becoming inaccessible.

CM7-18658

Console - Data: Attempting to rename a copied View Settings item, immediately after
moving, could cause an incorrect error message to be displayed.

CM7-18898

Studio - Processing Method: In certain tables (component table, SST/IRC table,
detection table, and peak properties pane), partial copy/paste did not work properly.
Instead the entire string was pasted or replaced, depending on the selected action.

CM7-18908

Help & Manuals: Chromeleon help incorrectly depicted the Signal-to-Noise RMS
formula. The lower bound of the summation was shown as i-1 instead of i=1.

CM7-18956

Studio - Spectral Plot: If another ion was converted into a quantitation ion, the label for
the existing quantitation ion was not correctly updated.

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Description

CM7-18992

Console - Injection Query: When querying for sequences not created by an eWorkflow,
Chromeleon returned false positive hits.

CM7-19044

Performance: Sequence upload used to be slow in Wide Area Network when a large
number of sequences are being uploaded concurrently. Upload performance has been
significantly improved in this release.

CM7-19080,
CM7-19081

Console - Data: When modifying a sequence or child object, if an object was then
copied into the sequence and modified directly thereafter, the data audit trail did not
capture the modifications for the recently copied item. The audit trail now includes an
entry to document the change but refers to the same version.

CM7-19093 CM7-19097

TRACE GC Ultra, Perkin Elmer GC, Agilent 7890 GC, Shimadzu GC, Varian 3800 GC:
When an instrument method was created with a detector acquisition range other than
the default (0 – run time), the acquisition range would revert to the default values
when the method was closed and re-opened

CM7-19105

eWorkflows: When creating a sequence from an eWorkflow, the Re-injection field's
maximum value was incorrectly set to 99 instead of a larger value.

CM7-19206

Studio - Data Processing: Cell borders of rows and columns of Integration and Summary
Tables were not always maintained if the tables were resized, for instance while
switching between injections. The cell borders now persist as set by the operator.

CM7-19209

Console - Import/Export: After importing Atlas workbook data, then converting to be
processable in Chromeleon, the Save button was not enabled, requiring users to click
another sequence or folder to be prompted to save the conversion.

CM7-19216

Console - Sequence Editor: If an injection status is changed from Finished to Idle, a stale
GUID persists in the GUID field until injection is re-run.

CM7-19222

Console - Import/Export: Importing a Chromeleon 6 Quantitation Method into
Chromeleon 7 would cause a "Value out of range" error to be displayed if the method
contains Maximum Wavelengths >900.

CM7-19225

Studio - Peak Properties Pane: Changes made to the Peak Properties pane were not
properly saved to the View Settings

CM7-19239

Studio - View Settings: It was not possible to resume a sequence with unsaved view
settings.

CM7-19264

Administration Console - Discovery: It was possible to remove local Data Vault Services
using the Delete key on the client's keyboard.

CM7-19288

Console - Data: If a Sequence was left open in the Console for an extended period of
time (e.g.: overnight) and then, before performing any other actions, a different
sequence was opened, a "Collection was modified; enumeration operation my not
execute" error could be observed.

CM7-19300

Studio - Report Designer: When printing a sheet of a report template, the
corresponding row heights could be affected by row height settings of a previously
selected sheet.

CM7-19354

ICS-3000/ICS-5000 PDA: Several non-functional ePanel features have been removed,
e.g., lamp age, limits, etc.

CM7-19374

Console: Adding a new instrument PC to a Chromeleon domain could result in improper
display of remote data vaults on that PC or of the new PC's local data vault on remote
PCs.

CM7-19435

ICS-2100: Configured with to EGCs, the second EGC (EGC-2) panel would not display in
SII for Xcalibur.

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Description

CM7-19443

Console - Data: If an IPC becomes disconnected from the network during acquisition,
and the currently-running injection is then opened on a different computer, an
exception error could be reported.

CM7-19446

ICS-4000: ED device panel would in some cases not display the ED signal.

CM7-19485

Studio - Spectral Plot: If the user re-arranged the order of stacked chromatograms
interactively, then the order of the relevant spectra plots was not automatically rearranged.

CM7-19487

ePanel - IC Systems: The measured temperature value on the ePanels for the ICS-1100,
ICS-1600, ICS-2100, and Aquion systems was reporting incorrect information.

CM7-19532

Console - Import/Export: The .cmbx Save As dialog box did not clearly display which
version of the .cmbx format was being created by the save.

CM7-19552

Studio - Processing Method: If a manual integration on a chromatogram was rejected
for any reason, the relevant chromatogram was never-the-less marked as modified.

CM7-19556

Studio - Data Processing: SmartLink would not work for calibration plots when MS
Quantitation was the selected channel.

CM7-19567

Studio - Processing Method: It was possible to create a peak list using the Chromeleon 6
detection algorithm and evaluating the “Find valley” method for unresolved peaks
where one of the peaks was detected via a peak group start/end parameter set to Auto.
In rare cases when using this method, this would lead to an invalid peak list where the
next peak start is before the current peak end that would then produce an error upon
reading the data in Chromeleon 7.

CM7-19571

Administration Console - Scheduler: Setting up a scheduler task including a Chromeleon
6 query, would sometimes force the user to enter credentials.

CM7-19573

Administration Console - Scheduler: When a Chromeleon 7 system had only one
Chromeleon 6 Data Source mounted, the Data Source could not be selected in the
Administration Console Task Dialog.

CM7-19575

Data Processing - Extracted Ion Chromatogram: When using regional settings which use
commas for decimal places, Chromeleon improperly interpreted this as a value
delimiter in the Extracted Ion Chromatogram dialogues. This resulted in error messages
in some instances.

CM7-19581

Console - Instrument Queue: After a user submitted a sequence and checked the
‘export report’ option, if a second user attempted to view the queue for that
instrument, it was possible that the error message “You must take over control before
operating this instrument” was displayed many times.

CM7-19585

Data Audit Trail: If Data Vault versioning was not enabled at the point when an item
(Chromatogram, Processing Method, etc.) was created (whether created directly or by
importing a .cmbx), it was not possible for Chromeleon to compare subsequent
versions against the initial version, because no initial version was available.

CM7-19587

Studio - Chromatogram View: When viewing overlaid plots in mirrored mode, the peak
annotations on the mirrored plot were drawn incorrectly. This occurred in both the
Chromatogram pane of the studio as well as the chromatogram plot object in reports.

CM7-19603

Studio - Intelligent Run Control: As the ‘Reinject’ IRC step was used repeatedly to create
a very large sequence, the pause between injections would grow significantly (To
several minutes after 4000 injections)

CM7-19644

Console - Data: A completed sequence would sometimes still be shown as running in
the navigation pane data vault tree.

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Description

CM7-19648

Data Processing - MS Components View: When visualizing SRM with multiple
transitions, the mass peaks at both extremities of the filter was also the MS plot m/z
scale range limits. This prevented users from seeing the lowest and highest SRM peaks.
Padding has been added so that the peaks at the extremities can also be observed.

CM7-19653

Studio - Processing Method: AvCF calibration would always average multiple levels with
the same amount. This has been changed to an option.

CM7-19675

Console - Multi-User Data Vault: When the User Mode feature was disabled, the
Downtime tab of the data vault properties was not available.

CM7-19711

Console - Sequence Editor: Attempting to open the Instrument Method of any
Sequence on a Japanese version of Windows would result in a Chromeleon error being
displayed.

CM7-19820

Method Editor - Exactive Series MS: Some copy, rename, and delete folder functions
will result in stale tune file lists in the Exactive Series method editor which required a
restart of the Exactive service when using Exactive Series versions older than 2.7.

CM7-19825

Instrument Audit Trail: When an instrument audit trail was corrupted (missing the raw
file), the ‘Instruments’ category of the Console was unable to connect to the instrument
and the system reported that it could not save the audit trail.

CM7-19832

Studio - Processing Method: When using a Processing Method outside a sequence, it
was not possible to select or edit component names during creation or editing of an
SST/IRC test case.

CM7-19843

Administration Console - Scheduler: Signed Chromeleon 6 sequences that were
transferred to Chromeleon 7 using the Scheduler couldn't subsequently have the readonly check box cleared to unlock the sequence. If the user has the required privilege the
read-only check box can now be cleared.

CM7-19845

Console - Sequence Editor: When attempting to assign an instrument that was not
connected via the Assign Instrument option in the sequence control bar, Chromeleon
stated it was unable to establish connection to the instrument. When clicking the Work
Offline' option after that an exception was displayed.

CM7-19856

ISQ and TSQ 8000: Changing configuration settings (such as the pressure units) in the
configuration dialog would cause a break in communications with the hardware

CM7-19872

Administration Console - Scheduler: An out of memory exception could be encountered
when transferring large amounts of data from Chromeleon 6 to Chromeleon 7.

CM7-19907

UltiMate Pump Panels: If more than one UltiMate-3000 pump was configured, some
eluent percentage controls were not visible on the device ePanel.

CM7-19909

Console - eWorkflows: When dragging and dropping an eWorkflow to a destination
such as the PC desktop, a folder outside of Chromeleon, or an application such as
Microsoft Word, the Chromeleon Console results in a crash.

CM7-19946

Studio: Opening large MS sequences caused a spike in memory usage, resulting in slow
performance and “System out of memory” errors.

CM7-19955

AXP: Creation of an instrument method would sometimes add an unnecessary Wait
Pump.Ready command.

CM7-19966

Setup and IQ: The  element was not automatically
added into the CmConfig.xml file following upgrade to a version of Chromeleon which
supports Replication Framework.

CM7-19977

Console - Data Audit Trail: Saving a data item after restoring a previous version, could
sometimes fail if any other Data Vault had become inaccessible during the time the
Chromeleon Console was open.

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Description

CM7-20033

Integrion/ICS-4000/ICS-5000: When attempting to delete a custom waveform in the
Integrated Amperometry mode, a "save" dialog would be displayed even if no changes
were made.

CM7-20034

Integrion/ICS-4000/ICS-5000: When attempting to delete a custom waveform in the
Integrated Amperometry mode, the expected "delete waveform" dialog would be
unexpectedly followed by a "save" dialog.

CM7-20090

Console - Injection Query: The instrument column in the query results listed the
instrument which was connected to the instrument method. It now lists the instrument
captured in the injection audit trail or, if the sequence did not run yet, the one assigned
to the sequence.

CM7-20138

Studio - Report Designer: In the Autorepeat Area Settings, attempting to select a
custom variable from a list as part of the autorepeat conditions resulted an empty list
and an 'Invalid arguments are converted to default values' message.

CM7-20155

Preconditions Log: Running a script or other activities that occur before an injection
would cause the problems with extracting information from the preconditions log to
display in a report.

CM7-20196

Studio - Report Designer: Custom Formulas were not listed as a category in the report
formula editor of an SST summary table. They were however, available by typing in the
formula field.

CM7-20197

Studio - Report Designer - Header/Footer: If the number of characters in a header or
footer exceeded 255, the text would simply be truncated. This was hard to detect in
advance if variables were used in the header/footer. More and better warnings are now
provided, and the length is calculated for the current injection in order to provide an
earlier indication to the user.

CM7-20205

Administration Console - Scheduler: The audit trail date range defaults were set to
display dates in the past. The dates now default to the current date.

CM7-20240

Console - Sequence Editor - Retry Upload: After an upload failure of the automatic
upload of a completed sequence the Retry function did not always work.

CM7-20252

A2D: If the Data Collection Rate was not set as part of the A2D instrument method,
"Data out of sequence @ point #" errors would sometimes appear in the Injection Audit
Trail.

CM7-20274

ICS-4000: EGC, CR-TC and CES controls on the home panel would show as active even
when not configured. Clicking one of them would issue an unknown symbol error.

CM7-20305

Export: When exporting (e.g. to pdf) a plot containing overlaid chromatogram data
from more than one sequence, the overlay order was different when exporting from
‘current sequence’ compared to exporting from ‘current injection’.

CM7-20323

Console - Import/Export: When attempting to import a cmbx containing linked
sequences which themselves contain linked objects, the import would not complete.

CM7-20326

Network Installation: When running across different Windows sub-domains, the Global
Policy setting for host name resolution "Always use FQDN" did not resolve hosts in
those different sub-domains and Chromeleon stations in different sub-domains were
not visible.

CM7-20327

Network Installation: When running across different Windows sub-domains, local Data
Vaults of Chromeleon stations in those different sub domains were not visible.

CM7-20359

Installation - IQ: When the Instrument Server service fails to install, the installation
went to completion resulting in an inoperable Instrument Controller. The installation
process has been updated to roll back the installation when the Instrument Server
service fails to install.

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Description

CM7-20381

Console - Data: It was not possible to delete a processing method containing a fixed
blank run injection or fixed calibration injection.

CM7-20392

Console - Import/Export: When a sequence is exported to cmbx, Chromeleon provides
an option to deselect one or more of the sequence's injections. If a cmbx created in this
way is then imported into a different data vault, Chromeleon would report an error and
the import did not complete.

CM7-20394

Shimadzu SIL-20A/SIL-30A: When using tray type "96 (deep) well plate" the positions
1_BAx to 1_BHx were incorrectly marked as invalid.

CM7-20395

Reporting: When using the Dissolution Templates from the extension pack, the chart for
Stage 1 dissolution profile did not show Samples 1 & 2.

CM7-20400

Network Installation: When host name resolution is set to "Always use FQDN", startup
performance has been significantly improved.

CM7-20429

Console - Injection Query: Creating and running queries with many custom variables
was slow for large data sets. Chromeleon 7.2 SR5 includes several performance
improvements for displaying queries in the Console, switching between "injection" and
"sequence" categories in query definition, enumerating possible values for a custom
variable (clicking the arrow-down-button to expand that combo box), querying for a
certain custom variable value and querying for a certain inject time or inject time range.

CM7-20450

Studio - Data Processing: Opening a Chromeleon 6.8 processing method from a
Chromeleon 6.8 data source to view the spectral library screening settings would
sometimes throw a null reference exception error and prevent Chromeleon 7 from
displaying the method.

CM7-20478

Console - Import/Export: When creating a backup (with versions) of a sequence
containing certain injections (deleted, fixed blank run or fixed calibration) the raw data
(file data) contained in the injections were not contained in the backup.

CM7-20481

ICS-3000 VWD: Control for Input 3 and for all Relay edit boxes were linked to the
incorrect controls and were permanently disabled.

CM7-20482

CDF Import: When importing CDF files with improper units and/or scaling factor the
resulting data in Chromeleon were not scaled correctly and x-axis was not labeled as
expected.

CM7-20497

Studio - Data Processing: When peak grouping functionality is used for calibration
combined with identical component names, if one component is not detected,
Chromeleon incorrectly used the peak area from the first detected component instead
of zero, resulting in incorrect summed peak areas being used for calibration.

CM7-20507

eWorkflows - Sequence Layout: After importing an eWorkflow with result variables in
the injection list the sequence layout grid was not displayed properly.

CM7-20510

Studio - Processing Method: If using the AvCF calibration and any disabled points didn't
have an amount, this would lead to a "value must be finite" error.

CM7-20516

Administration Console - Scheduler: Import of Chromeleon 6 Sequences used to fail if
any components had names >64 characters long. Component names can now be up to
128 characters long, above which the importer will now truncate the name and record
this in the CM6ImportLog.csv.

CM7-20522

Studio - Processing Method: If a peak delimiter had a small intersection (time difference
<1e-12) with an inhibit integration region and a peak apex was on such a delimiter, this
would prevent the chromatogram being shown.

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ID

Description

CM7-20525

Console: It was possible that an upload of a sequence or copying of a finished injection
between sequences could result in an error exception if the Windows long time format
was set as HH:mm:tt. Any date and time format is now accepted without incurring an
error exception.

CM7-20526

Audit Trail of Deleted Items: When an item e.g. a folder was deleted from the Data
Vault Chromeleon moved the item to the "Deleted items" folder but the operation was
not shown in the audit trail of the "Deleted Items" folder. Restoring the deleted item
also was not shown in the audit trail of "Deleted Items".

CM7-20539

MS Instrument Control: When a method with a large number of SRMs (>1500) was
acquiring, the ePanel would freeze and the client disconnect from the acquisition server

CM7-20544

Administration Console - Scheduler: In the Scheduler, when using a query to import
Chromeleon 6.8 data from a Chromeleon 6.8 data source, one of the sequences would
sometimes cause an invalid operation exception error and could not be imported.

CM7-20551

Administration Console - User Database: During the process of creating new
Chromeleon accounts, especially in a network environment, the time taken to switch
between tabs could be slow, sometimes resulting in a "Not Responding" error message
being displayed and the Administration Console becoming greyed out.

CM7-20561

Agilent 7890 GC: Selecting an Auxiliary Pressure Controller in the Instrument Method
Wizard prevented completion of the wizard

CM7-20570

Administration Console - Scheduler: The text used for some Column and Tab titles in
the Scheduler section of the Chromeleon Administration Console was inconsistent.

CM7-20574

Spurious Files on the Instrument Controller: After resetting already acquired injections
to "Idle" status before removing from the queue the related raw files remained on the
disk.

CM7-20576

Services - Discovery: Issues with network and/or dependent network services (e.g.
Windows' Net. Tcp Port Sharing Service) could result in the Chromeleon 7 Discovery
Service failing to start, after which manual restart would then be required.

CM7-20577

Reporting: When reporting mass spectrum intensities, an incorrect intensity value was
reported when there was no response for an m/z value

CM7-20579

Virtual Column: Opening the "Orange Juice Sugars" file no longer throws unexpected
error.

CM7-20584

Studio - Report Designer: Unlocked cells in a protected sheet could not be edited or
cleared. It is now possible to enter text, make an edit or clear any cells that are
unlocked.

CM7-20609

TRACE GC Ultra: It was not possible to set the 'SVE Time' parameter for the LVOCI check
valve. As a result, the SVE Temperature was not applied during acquisition.

CM7-20610

Data Acquisition - MSQ Plus: Aborting an injection mid-run while acquiring data with an
MSQ Plus resulted in corrupted data that could not be opened.

CM7-20615

Licensing: During an outage of the central Domain Controller it was only possible to log
on to a terminal server session of Chromeleon after several minutes.

CM7-20618

Setup and IQ: If a Chromeleon process needed to write to the Windows Event Log, but
was not running as with Administrator privileges, the log would not be written, and in
some cases this would cause a crash in the process.

CM7-20619

Setup and IQ: If Windows update KB3033929 was not installed, the IQ would present a
misleading warning regarding driver functionality. The warning has been updated.

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Description

CM7-20633

Help and Manuals: The Help indicated that it was possible to extract a signal from a 3D
field and specify the RefWavelength. This functionality is not yet available in
Chromeleon 7, so the Help has been updated.

CM7-20639

Printing: Pressing the ‘Cancel’ button while a print job was in a 'computing results' state
didn’t cancel the print job.

CM7-20649

Console - Import/Export: When a sequence of AnDI / NetCDF (AIA / ALSSA) data was
imported into Chromeleon, the conversion process incorrectly assumed that the
acquisition time read from the AIA file was in local system time.

CM7-20652

Studio - Report Designer: A check has been added to ensure that a null-reference error
is not thrown when accessing the Page Layout tab.

CM7-20653

Studio - Data Processing: When using the zoom function on a plot, drawing of the zoom
area when clicking and then dragging the mouse does not accurately represent the
intended start point or final zoom area. Attempting this in an environment that uses
desktop virtualization would often greatly exacerbate this problem.

CM7-20659

Setup and IQ: The Chromeleon IQ report did not clearly show the time zone of the
system on which the IQ had been run.

CM7-20665

Agilent LC (ICF): If using certain parameters in the Agilent method, the report variable
LCSystem.ALS.Injection_Volume does not report the final volume used in the analysis.
Thus it is not recommended to use this variable in a Chromeleon report.

CM7-20684

Studio - Chromatogram Pane: It was not possible to manually integrate overlaid
chromatograms, if the chromatograms exactly overlapped.

CM7-20693

Studio - Processing Method: When using a Retention Time Standard processing
method, adjusting the peak area ratio tolerances, then changing the method to
evaluate a specific channel after being originally being set to evaluate all channels,
could result the peaks not being labeled.

CM7-20715

Studio - Processing Method: If the apex of the last peak in a peak group coincided with
the end of the peak group, the peak was not added to the group. This would result in an
apparent overlap of the peak with the group, leading to the chromatogram not being
displayed for the injection.

CM7-20716

Studio - Reporting: In some situations, a deviation could be observed between the
electronic results and any printed results.

CM7-20721

Console - Import/Export: Importing Chromeleon 6 sequences containing instrument
audit trails resulted in an unexpected error.

CM7-20728

Studio - Instrument Method: Some instrument-specific information was added to the
Description field of the Instrument Method during creation. This information be
incorrect if the method was then used for a different instrument. This information is no
longer added to the description field.

CM7-20729

Instrument Controller: A sequence submitted by a client PC could disconnect from the
instrument controller PC after being submitted. This occurred in a multi-zone DNS
network (with at least 2 different DNS suffixes), where the Instrument Controller and
Client PCs have different DNS suffixes.

CM7-20742

Setup and IQ: The Chromeleon 7.2 SR3 Release Notes and List of Supported Instruments
were not included in the Documents\Previous Versions folder of the Chromeleon 7.2
SR4 setup DVD.

CM7-20750

Console - Custom Variables Editor: The Custom Variables Editor would allow the
creation of multiple custom variables with the same name, and this would cause the
Data Vault to become inaccessible

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ID

Description

CM7-20762

Sequence Editor - Properties: When trying to change the properties of a downloaded
but inaccessible sequence was attempted with the replication framework turned on,
Chromeleon would throw an unhandled exception error.

CM7-20764

URG-9000: Last injection data would not display on home ePanel.

CM7-20769

Administration Console - User Database: Previously when selecting privilege categories
or individual subordinate privileges of a Role, the selection could be made via clicking
within any of the columns of the privileges row. Now in order to enable or disable a
privilege the selection but be made in the Privilege column.

CM7-20770

Studio - Processing Method: It was not possible to save any changes to a processing
method containing reference spectra if the sequence had been downloaded to a
remote PC.

CM7-20789

Console - Instrument Queue: The setting for the ‘Print Report’ option in the
‘Instrument’ category of the Console was not synchronized setting in the ‘Instrument
View’ window. This resulted in reports sometimes not being printed as expected.

CM7-20817

Studio - Report Designer: If using a consolidated table for reporting, unidentified peaks
were added to all matching rows of rows of the table, which led in some instances to
duplicate peaks.

CM7-20828

Studio - Chromatogram View: Customized Chromatogram colors were not correctly
imported when a Chromeleon 6 Sequence was viewed in Chromeleon 7.

CM7-20830

Data Vault Manager: If the local Data Vault Service was not running, Data Vault
Manager would still run, but would report an error when attempting to perform Data
Vault management actions.

CM7-20836

Negative Peaks: When a negative peak was defined using manual integration, the
retention time was reported as the peak start or stop time, not the peak nadir (negative
apex).

CM7-20857

Integrion: The Integrion IC Knowledgebase would display the CDet panel, even when no
CD detector had been configured in the Instrument Configuration Manager.

CM7-20875

Sequence Editor - Lock Injections: It was possible to lock injections in a sequence that
was on the XVault even though the data vault did not allow versioning.

CM7-20885

Console - Import/Export: When attempting to import a cmbx containing linked objects
not accessible from the user's PC, the import would not complete.

CM7-20893

Studio - Processing Method: The Cobra Wizard did not show any peaks if one
component had the previous retention or RTS (Retention Time Standard) setting
activated.

CM7-20903

Instrument Configuration Manager: Applying a long access control list (e.g. >15 users)
to an instrument sometimes resulted in an internal communication error. Afterwards,
unauthorized users were still able to access the instrument.

CM7-20904

Export: Exporting a pdf format report to a network location was much slower than
exporting to a local folder on the PC when the network location was physically far (e.g.
connected by a WAN) from the client PC doing the export.

CM7-20909

ICS-4000: Changing the CDet device name no longer prevents the CD signal from being
displayed on the home panel.

CM7-20910

Console - Multi-User Data Vault: When a data vault with downtime defined was moved
to a new data vault server, the downtime tab was no longer available.

CM7-20913

Instrument Configuration Manager: Submitting a sequence to an instrument with
unsaved changes to the instrument configuration did not generate any warning or error

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ID

Description

CM7-20929

Studio - Instrument Method: Save as for an instrument method without having the
privilege did not save but also did not show an error message that the user doesn't
have the privilege.

CM7-20930

Studio - Data Processing: An unhandled exception was observed when using Smart
Peaks in combination with the previous retention setting for a component.

CM7-20933

Console - Custom Variables Manager: When creating a custom variable of type "list," it
was not possible to set a blank value as default, even if empty values were allowed.

CM7-20935

Chromeleon 6 Import - Instrument Methods: Importing a Chromeleon 6 instrument
method (PGM file) resulted in an additional "post run" step in the Chromeleon 7
method. Although this did not matter for most methods, it caused dual injection
methods to fail.

CM7-20936

Studio: With user management enabled, copying a report template from another
sequence in the Studio sequence would generate an error claiming “The privilege
‘Create Report Template’ is missing”, even though this permission should not be
required.

CM7-20957

Reporting: It was possible to include leading or trailing spaces in a channel or
component name when setting these properties for a whole report table or a single
report column. In this case the report table or the report column showed ‘n.a.’ for all
results. The corresponding input procedure in the report table properties dialog has
been corrected now. Leading or trailing spaces for channels and trailing spaces for
component names are now removed after the input. For already existing reports
showing this behavior the corresponding properties channel / component name need
to be reentered to get it fixed.

CM7-20963

Reporting: When using a Data Audit Trail table in any but the first sheet of the report
for a printed or electronic report or export, the resulting table was always populated
with details from the first injection.

CM7-20971

DC-5000+: CD and ED Analog Out Range, Full Scale and Offset Level (ED only) controls
now allow user to set those parameters.

CM7-20982

Studio - Calibration Plot: If the calibration option "Average all response values for each
calibration level before curve fitting" was selected, disabled points would disappear
from the plot, instead of being displayed but crossed out

CM7-20983

Export / Report from Queue: Automatic generation of export files and reports from the
Queue after the end of each injection sometimes skipped an injection.

CM7-20986

User Management: When the policy setting for LDAP is enabled, the User Database
password complexity policies such as Password Complexity Sets and Minimal Password
Length were not checked for a user that was excluded from LDAP authentication when
resetting that users logon and signature passwords. This problem has been fixed for the
logon password and the signature password of users excluded from LDAP
authentication.

CM7-20988

Console - XVault: If a user tries to upload a finished sequence without taking control
while another user is actively running another sequence, Chromeleon will throw an
error message.

CM7-20989

Console - Data - Send To: It was possible that when trying to overwrite an existing
Chromeleon data file that had Read-only attribute set, the Console would stop working.
The Console no longer stops working and a dialog is now displayed that notifies the user
that the existing file is read-only and that an alternative name for the .cmbx file is
required.

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CM7-20995

ePanels - DGP-3600(RS, SD): If a DGP was shared between two instruments, the Startup
ePanel would show the left half on both instruments, and incorrect symbols on the
right half. The panel has been improved such that the correct half is shown, and unused
controls are greyed out.

CM7-21013

Console - Import/Export: When creating a backup (with versions) of a sequence
containing certain injections (deleted, fixed blank run or fixed calibration) the raw data
(file data) contained in the injections were not contained in the backup.

CM7-21015

Agilent Infinity II Multisampler: When using the Multisampler with 384 well plates in
each slot an error "Error parsing tray layout" occurred.

CM7-21021

Agilent LC (ICF): If using a G7151A, or G7117A/B, it was not possible to configure the 3D
within Chromeleon.

CM7-21042

TRACE 1300 GC: When using monitor baseline for the TRACE 1300 GC, the AcqOn
commands were executed, but no data was acquired.

CM7-21043

Agilent 6890/7890 GC: When an instrument method using a Chromeleon version before
7.2 SR3 was opened using version 7.2 SR3 or later, the Column parameters were
deleted

CM7-21046

Studio - Report Designer: It was possible to rename a Report Template within the
Report Designer category of the Studio even though the Rename Report Template
privilege was not granted. The option to rename a report template is now greyed out if
the user's role does not have the Rename Report Template privilege.

CM7-21047

TRACE 1300 GC: On the PTV page of the method editor, once the Cryogenics option was
disabled, it was not possible to enable it again

CM7-21050

AS-AP: Controls on the Relays sub-panel are now properly displayed.

CM7-21074

Console - New Sequence Wizard: When trying to create very large sequences the
sequence wizard became unresponsive or reported an out of memory exception.

CM7-21076

AS: ICS-5000 OQ sequences were not generated with an AS module configured.

CM7-21078

Integrion: Smart Shutdown will now properly turn off the pump motor.

CM7-21082

Agilent 7890 and 6850 GC: If the Autozero command was removed from the instrument
method script, it reappeared when the instrument method was reopened.

CM7-21083

Console - Import/Export: When importing a .cmbx file that contains a sequence that
already exists in the destination that you are trying to import to, the existing sequence
was overwritten. Now when importing if an existing sequence has modifications
pending or is downloaded, running, electronically signed, has locked injections or is set
as read-only, the existing sequence cannot be overwritten and either the import can be
cancelled or the user can skip the import of the sequence and continue importing.

CM7-21085

Studio - Data Processing: When running in a Citrix session, graphical artifacts were left
on the screen.

CM7-21094

Integrion: Smart Startup was unable to start the CR-TC.

CM7-21110

Sequence Data Audit Trail: When different objects inside a sequence were changed and
then saved in one transaction the change records for the individual objects were not
shown in the sequence audit trail.

CM7-21113

Console - Data: Sequences with electronic reports containing references to external
spectral libraries could not be copied.

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CM7-21119

Console - Data: In instances where the data vault contains a large number of file
objects, the connection time could become excessively high when initially attempting to
connect to the data vault.

CM7-21130

Agilent 7890 GC: The option to turn on the detector electrometer was missing from the
method editor user interface

CM7-21131

Console - Import/Export: If a sequence was imported via a CMBX file, restored to an
older version, deleted, and imported again to the same location, the next restore action
would throw an exception error.

CM7-21139

Studio - Processing Method: peak.levelCheck and injection.levelCheck report variables
no longer display differing results when using different curve fitting settings.

CM7-21159

Console - Import/Export: If the user attempted to export data where the x-axis units
were not a time unit, an error was reported.

CM7-21187

User Management: When a  Organizational Unit is imported, Chromeleon will
resolve any conflicts with any existing  Org Units, but this resolution process
did not always complete correctly.

CM7-21250

Studio - Electronic Report: The Comment field when entering an Electronic Signature
did not limit the number of characters, but would lead to an unhandled exception if
more than 255 characters were entered.

CM7-21269

Export: Export of files (e.g., Excel, PDF) during long sequences (100+ injections) would
take extremely long. Performance has been significantly improved.

CM7-21272

Services Manager: The Service Unavailable time stamp did not show the time zone
offset, and was therefore inconsistent with other time stamps.

CM7-21285

Studio - Spectral Library: When attempting to use the "Find Spectrum in Library"
function from the context menu of a chromatogram, the library search window did not
appear.

CM7-21289

Setup - Data Vaults: Previously when running setup without any configuration the
database schema of all local Chromeleon data vaults, including multi-user data vaults
were updated. The setup by default now skips the data vault schema update when a
data vault is a multi-user data vault.

CM7-21302

Studio - Chromatogram View: For some pumps (including the ICS-5000), the gradient
graph overlaid on the chromatogram did not accurately plot the curve types from the
pump method.

CM7-21309

Installation - Upgrade: When attempting to upgrade a Chromeleon instance pointing to
a discovery server that no longer exists and the cached domain data is older than 7
days, installation would result in errors. The cache validity has been extended to 30
days.

CM7-21310

Console - Data: If any network issues caused Sequences to fail to download, the failed
Sequences would not be removed from the download queue on the Data Vault server
and would cause the downloaded of subsequent Sequences to be blocked.

CM7-21315

User Management: Previously the privilege 'Modify Status of Already Finished Or
Interrupted Injections' applied to all injections regardless of whether they did or did not
contain raw data. The privilege now only applies if the Finished or Interrupted injection
has raw data.

CM7-21325

Instrument Configuration Manager: With access control set up for the Instrument
Controller, adding, deleting or renaming an instrument removed access control for the
entire Instrument Controller.

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CM7-21340

OQ/PQ: In order to correct some minor typographical errors, the front page of the
HPLC-IQ Release Notes was updated; the revision level remains at 4.00.

CM7-21348

User Management: In a Chromeleon system with a combination of LDAP and non-LDAP
users, if an Administrator sets the "Must Change Logon Password" option for a nonLDAP user, that user would not get prompted to change their password.

CM7-21363

Electronic Report: Under rare circumstances a chromatogram plot in an electronic
report showed an error message "Can't read channel UV_VIS_1 from injection #<#> . There is already a chromatogram cache write operation in progress."

CM7-21370

Sequence -Versioning: Restoring a previous version of a sequence form the data audit
trail did not prompt the user to save the restored version if sequence was not
highlighted in the data tree

CM7-21375

Aquion: With flow zero set in configuration, the status of Pump_ECD_Relay_2 would
not change when the pump flow was set to on or off.

CM7-21376

AS: Switching an injection valve in a German Windows 7 OS environment is no longer
prevented.

CM7-21383

Data Audit Trail: When a user submitted multiple sequences for acquisition using
multiple roles having different folder permissions, it was possible for the data audit trial
of a sequence to be lacking ‘Started run’ and ‘Finished run’ entries.

CM7-21385

eWorkflows with Custom Injection Variables: After importing a numeric Custom
Injection Variable into an eWorkflow Variable the Value Type seemed to change to text
and the properties could not be viewed upon saving and reopening the eWorkflow.

CM7-21391

Processing Method - IRC/SST: When attempting to use the number of re-injections as a
custom condition for an IRC, the test would not execute correctly, owing to use of an
incorrect formula by the custom condition editor.

CM7-21418

Console - Import/Export: Producing PDF and Excel exports simultaneously would result
in incorrect page numbering in the exported files.

CM7-21442

Sequence Custom Variables: When a numeric custom variable was included in a
sequence table, it was possible to change the valid limits of the variable such that the
existing table values were invalid. However, no error was reported and closing and
reopening the Console caused a “Could not load data for child item” error.

CM7-21446

Console - Import/Export: If a processing method containing a response factor of zero
was imported from Chromeleon 6 into Chromeleon 7, the import would fail.

CM7-21453

Administration Console - User Database: In order to refresh the user database audit
trail you would have to navigate away to another section of the administration console
and back again to see any changes. It is now possible to refresh using either F5 or by
clicking the Refresh button.

CM7-21455

Instrument Configuration Manager: If a PC did not have a ‘My Documents’ folder, the
instrument configuration manager would crash immediately upon connecting to the
instrument controller.

CM7-21459

Console - eWorkflows: Searching eWorkflows via the filter was slow due to automatic
connection attempts to the instruments in the background.

CM7-21462

Report Variables: When working with a channel extracted using extraction type TIC
from an MS filter with more than one SRM transition, the report variable
chm.msExt.massRanges only reported the first transition range.

CM7-21491

Administration Console - User Database: User Management Audit Trail grouping was
case-sensitive, potentially resulting in multiple 'group' rows for the same Operator, if
the name had been entered with inconsistent cases.

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CM7-21501

Studio - Processing Method: If a custom formula was used in the SST/IRC calculation,
then the name of the analyte was not displayed correctly in a report.

CM7-21503

Custom Formulas: The limit for nested evaluations of custom formulas has been
increased to 50.

CM7-21513

Studio - Reporting: If a component peak was missing from an injection, results such as
calibration information, which does not require detection of a peak in an unknown
injection, would not be calculated when associated report variables were used in single
spreadsheet cells and result columns of injection tables in the console.

CM7-21514

Console - Injection Query: It was not possible to run a query that was using a Custom
Variable that did not exist in the target Data Vault. The query is now valid and return no
results as expected.

CM7-21516

Console - Data: When starting up the Data Vault service did not publish access control
for Data Vaults so that Data Vaults were visible to users who should not see them.

CM7-21523

Console - Instrument Queue: After adding two sequences to the queue and starting the
queue, when specifying a time in the "Start After" column for the second sequence and
clicking on the "Start After" of the first sequence (which is empty), the "Start After"
value of the second sequence disappeared.

CM7-21527

Studio - Data Processing: Performance was poor when reviewing MS sequences with
large numbers of SmartLink'ed MS Component plots

CM7-21544

Console - Import/Export: When importing signed Chromeleon 6 data that was
tampered with in Windows Explorer, Chromeleon 7 would throw an exception error.

CM7-21549

Data Audit Trail: After restoring a previous version of a sequence and then saving the
injection and sequence separately, it was possible to sometimes have an incorrect
version number for the entry appear in the data audit trail table.

CM7-21553

Report Variables: When built by using the categories/sub-categories dialog, the
parameter chm.massSpectrum("","").* did not show the ‘Interactive spectrum’ and
‘Peak spectrum’ options available for that parameter.

CM7-21561

Console - Data - Sequence Properties: It was possible to change default report and view
settings of a sequence contained in a read-only Data Vault.

CM7-21562

Agilent 6890/7890 GC: The S/SL Inlet ePanel did not properly hide some parameters
based on the inlet mode despite them not being usable in that mode

CM7-21572

Performance - MS Data Processing: When calculating ion ratios for a large number of
components (>50), Chromeleon enters an unresponsive state for an extended period of
time. Performance of ion ratio calculations has improved and a progress indicator has
been added to provide additional calculation state feedback to the user.

CM7-21574

AS-AP: In some cases, when running a sequence with the sample overlap function
enabled, an unexpected "device is busy" error would be displayed in the audit trail of
the last injection.

CM7-21576

Injection Audit Trail: In some cases an aborted injection caused the injection audit trail
to be filled with abort error messages referencing an Object Null reference Exception.

CM7-21597

Chromeleon 6 Data Import: A single Electronic Report copied from a Chromeleon 6
Datasource into a Chromeleon 7 Data Vault caused an exception when opened in the
Studio.

CM7-21654

Performance: On very large systems, if a large number of IPCs were attempting to
upload sequences at the same time, the CPU usage of the lsass.exe process on those
IPCs could be high.

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CM7-21655

Reporting: When custom conditions were specified for the Autorepeat Area Settings
and components, the repeat area was only reported once (it did not Autorepeat as
expected)

CM7-21658

eWorkflows: With "Append Injection(s) if sequence already exists" enabled adding
injections by re-running the eWorkflow reset values of Custom Sequence Variables that
have been changed in the meantime. In such a case variables are no longer changed to
the default value and a warning is displayed.

CM7-21662

Compliance - eWorkflow: Even when versioning and comments were required for any
changes to data vault objects were enabled, creation, changes, or save as actions to the
eWorkflow did not display a comments dialog.

CM7-21664

Studio - Report Designer: The ms.spec_count report variable reported incorrect values
when applied to peaks.

CM7-21670

Studio - Processing Method: It was possible to have a whitespace (blank) character as
the group name in a component table if a column was filled down using F9 prior to
confirming the entry with the enter key. The fill down operation now removes the
whitespace characters before executing the fill down operation.

CM7-21681

Shimadzu GC-2014: On the instrument method editor page for the AuxAPC, both the
Pressure and Flow edit controls were disabled.

CM7-21704

Console - Signed Sequence: In certain cases it was possible to change the assigned
instrument in a signed sequence.

CM7-21713

Console - Sequence Editor: With versioning enabled restoring a previously locked
injection that has been unlocked in the meantime failed with an error when trying to
save the restored version.

CM7-21730

Studio - UV Spectral Library: It was possible to edit comment and other fields without
selecting a spectrum, leading to an exception.

CM7-21742

Reporting: If using AvCF calibration and having some disabled points, the peak variance
and some related variables (peak.variance, peak.standard_deviation,
peak.rel_standard_deviation, peak.confLowerLimit, peak.confUpperLimit,
peak.predLowerLimit, peak.predUpperLimit) were calculated using the total
count/number of all points. All reports created with a version prior to Chromeleon 7.2
CDS SR5 will contain different results for these variables from any reports created with
this or a later version.

CM7-21744

Console - Import/Export: When importing to the "Original Location" an error "Invalid
destination" was shown if the file did not exist.

CM7-21753

Performance - MS Data Processing: When processing and reviewing many sequences
containing MS data in tandem, a memory leak would cause Chromeleon to hang or
throw an out of memory error.

CM7-21775

Console - Import/Export: CMBX export previously allowed the "Include Versions" option
to be unticked for Sequences containing locked injections, potentially resulting in
incomplete data when the CMBX was imported. If a sequence contains locked
injections, the CMBX must also contain versions. If versions are not being included in
the CMBX, then any locked injections will be exported as unlocked.

CM7-21785

Console - Import/Export: When using drag and drop to create Chromeleon data files a
memory exception could possibly be encountered if the originating sequence was large.
The data is now streamed to a temp file rather than writing all the data to memory first.

CM7-21787

Data Audit Trail - Chromeleon 6: When viewing data audit trails for Chromeleon 6, from
Chromeleon 7, processing methods containing spectral data resulted in display of
multiple duplicate audit trail entries.

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CM7-21791

Administration Console - Discovery: When attempting to join a Chromeleon Domain
with ‘Push Notifications’ enabled, if a problem was encountered (e.g. with name
resolution), Discovery would still appear to successfully join the domain. However, this
would result in limited access to remote data vaults and other resources. The Discovery
Service now reports the problem and reverts to the previous configuration.

CM7-21802

Administration Console - Scheduler: Restarting the Chromeleon 7 Scheduler service
using the "Restart Service" option in Windows Computer Manager, rather than the
separate "Stop Service" and "Start Service" options, would sometimes fail because the
service hadn't fully stopped before Windows attempted to restart it.

CM7-21809

Data Vault Manager: If a square bracket character was used as part of a Data Vault
name an exception would occur, for instance when trying to create the Data Vault. It is
no longer possible to use square brackets as part of a Data Vault name when creating or
renaming Data Vaults in the Data Vault Manager.

CM7-21810

Console - Import/Export: It was not previously possible to add file attachments to
imported sequences.

CM7-21816

Console Version Comparison: When making an integration change to an MS component
for the very first time after an injection or restoring an injection, it was not possible to
compare the changes between the original and version immediately after the
integration change.

CM7-21840

Instrument Configuration Manager: When using the instrument configuration manager
to access an IPC that was part of a different Chromeleon domain than the client PC,
access privileges were not properly checked against the IPC domain.

CM7-21846

Administration Console - User Database: A user with the privileges LockInjections and
UnlockInjections might still be denied permission to lock/unlock injections. This
occurred when the folder containing the sequence had an Access Control List with
‘Deny’ for a role without those permissions, even if the user was not a member of that
role.

CM7-21848

Console - MS Data Import: When importing a large number of Xcalibur raw files (>150)
into Chromeleon, the import process would be aborted with an out of memory error.

CM7-21876

Reporting: Trying to print from the Report designer following install of Windows Update
KB3170455, caused an error.

CM7-21881

Performance - Reporting: When processing and reporting many sequences, a memory
leak would eventually cause Chromeleon to hang or throw an out of memory error.

CM7-21914

Setup: Connecting a Chromeleon dongle to a Chromeleon domain controller via a
USB2LAN converter now supports the dongle grace period in case of a power outage on
the Chromeleon domain controller.

CM7-21918

Performance: Some modal dialogs were not disposed after closing thereby causing
memory leaks and degraded performance over time.

CM7-21921

AS-AP: When a sequence was manually stopped, the autosampler would go into a notready state that would require a self-test to be run to bring it back to idle.

CM7-21923

Data Audit Trail Report: Creating a full data audit trail report for a sequence containing
at least one chromatogram change of an MS signal caused an ArgumentNullException.

CM7-21944

Fraction Collection: When the 'collect outside peaks' option was selected, fraction
collection continued even after the collection time window completed.

CM7-21947

Console - Sequence: When a sequence that has been downloaded to an IPC and is
inaccessible is opened in the Chromeleon Console, the opened sequence was in a readonly state. No changes to the sequence was possible, but some controls remained
active, giving the initial impression of a modifiable sequence.

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CM7-21954

Console: If an acquired sequence became corrupted in some way, attempting to
manually upload it to a remote data vault sometimes generated an error stating “A
Custom field with the mappingname = …already exists in the collection”.

CM7-21957

Studio - Chromatogram View: Attempting to use the Time Spectra tool to create an
average mass spectrum over a very long time range would generate a ‘Spectral plot
could not be created’ error message

CM7-21968

Setup and IQ: For Enterprise systems, the recommended setting for notifications is "Poll
for updates", but the installation kit selected "Receive push notifications" as the
default, thereby requiring subsequent manual selection of Poll on each Chromeleon
client.

CM7-21970

Console - Sequence Editor: In instances where a data vault uses an Oracle 12 database,
but the client PC does not have the Oracle 12 client installed, Chromeleon would throw
an exception error when trying to save a sequence.

CM7-21991

Console - Versioning: Save As (with and without Raw Data) both add a Save As item to
the Data Audit Trail. Additionally, Save As (with Raw Data) now also copies the Data
Audit Trail from the 'source' Sequence to provide full audit history of the data.

CM7-22005

Console - Data: Saving a data item after a version comparison, on a local Data Vault,
could sometimes fail if any other Data Vault had become inaccessible during the time
the Chromeleon Console was open.

CM7-22007,
CM7-22008

ICS-5000/ ICS-4000: The ED waveform sub-panel has been rearranged to list the
Ag/AgCl waveforms in the left column of buttons and the PdH and pH waveforms in the
right column of buttons.

CM7-22031

Studio - Processing Method: A memory leak when calculating ion ratios for MS
components multiple times results in an out of memory exception.

CM7-22032

Console - Data: It was not possible to rename objects such as instrument or processing
method that were stored outside a sequence.

CM7-22040

Performance: When running in a slow or heavily loaded network the Chromeleon
Console would become unresponsive during DNS lookup calls. DNS information is now
cached for improved performance.

CM7-22054

Varian Prep Star 218: If pressure limits were set in the instrument method, changes in
the values were not read correctly by the pump leading to pump control failing silently.
The limits need to be set on the pump itself, please see the on-line help for further
details.

CM7-22071

Administration Console - Scheduler: When a sequence was queued and downloaded to
the respective Instrument Controller of the sequence's assigned instrument and it
subsequently had the assigned instrument changed remotely to one that was
configured on a different Instrument Controller; attempting to run the sequence on the
newly assigned instrument resulted in a timeout error that could only be resolved by
restarting the Scheduler service on the Data Vault server. Several handling
improvements have been made such as preventing a user from changing the assigned
instrument of a sequence that is already downloaded so that the timeout no longer
occurs.

CM7-22082

Console - Import/Export: Chromeleon would report an error when importing a .cmbx
containing sub-folders, and with Access Groups assigned, onto a system without User
Management.

CM7-22083

Console - Data: When the copy operation of a large sequence was cancelled, the
cancellation process took over 5 minutes in some instances.

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CM7-22086

Console - Instrument Queue: When a sequence was submitted remotely to an
instrument queue, no report was generated at the end of the sequence, even though
that option was specified.

CM7-22095

Console - Injection Query: If the Chromeleon studio for an injection query is opened
while the query is still ongoing, an exception error was thrown.

CM7-22109

Studio - Reporting: If the calibration mode in a Processing Method was changed to
'Fixed' the details of the change were not displayed in the Data Audit Trail comparison
view of the Processing Method. Additional properties are now displayed and in addition
two new Processing Method Report Variables are provided: Last Fixed Calibration
Update Operator and Last Fixed Calibration Update Date & Time.

CM7-22119

Administration Console - Global Policies: The Global Policies report contained some
terminology that was inconsistent with the equivalent terminology in the Chromeleon
Administration Console.

CM7-22127

Studio - Report Designer: Excessive use of the chm.noise report variable in calculations
may result in memory leaks and decreased performance.

CM7-22160

Setup and IQ: The post-installation steps performed after updating Chromeleon 7 could
become 'stuck' on computers which also have Chromeleon 6 installed.

CM7-22161

Reporting: If using a custom condition to select peaks for which spectral plots should be
shown in an autorepeated area, this would only work if a comma was used as a
separator. It is now possible to use the separator defined in the Windows regional
settings.

CM7-22163

Reporting: Enabling "Lock Sheet" for an entire report template worksheet while leaving
"Lock Cell" disabled for each of the cells no longer degrades Chromeleon performance
when opening the template.

CM7-22185

Console - Processing Method Creation: When creating a processing method from the
Chromeleon Console in a downloaded sequence, unexpected behavior was observed.
The initial creation location of the processing method was defined as the XVault. If the
user then selected the network Data Vault, the newly created processing method would
be saved without prompting the user.

CM7-22207

Administration Console - Discovery: The Time Stamp displayed for Last Update time of
Domain Resources did not include Time Zone offset.

CM7-22208

Administration Console - Discovery: The Last Refresh column for Domain Resources was
not sufficiently wide enough to display the full information contained within the field.

CM7-22214

Setup and IQ: If after installing Chromeleon, the user installs any other software which
updates the Visual C++ 2013 Redistributable Package by installing only the 64-bit
version, this would remove the 32-bit version of the package. This 32-bit version is
required by several Chromeleon services, which would therefore no longer be able to
start.

CM7-22220

Sequence in the Queue: When removing a sequence from the Queue that has been
downloaded from a network Data Vault and that the current user has no control over it
was not necessary to take control over that sequence.

CM7-22224

Setup and IQ: When Chromeleon was updated on a system where the Data Vault
Service was running with an account other than the default "Local System" account, the
installer would revert the Data Vault Service back to running as Local System.

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CM7-22233

Injection Audit Trail: When a user modified an injection status from Finished to Idle, the
data audit trail indicated that the user deleted the data even though the user only had
the privilege to modify the injection. The data audit trail messaging has been improved
to indicate that the raw data was deleted due to modification of the injection status to
idle.

CM7-22240

Console - Sequence Editor: The Delete key did not clear a field of the injection list
unless the user has the privilege "Delete Finished or Interrupted Injections".

CM7-22252

Setup and IQ: Following an upgrade of Chromeleon, the IQ would incorrectly report an
error in the timestamp of the CM7Help_EN.CHM file.

CM7-22261

Administration Console - Discovery: Automatic refresh of the Domain Resources:
Computers list in the Administration Console while selecting computers (e.g. prior to
setting up a Maintenance Window) could result in the wrong computer(s) being
selected.

CM7-22271

Sequence Download Failure: When restoring a versioned instrument method into a
sequence the sequence history got corrupted and consequently the sequence could no
longer be downloaded with an error message "Error reading the sequence...".

CM7-22273

Console - Data: Using a Data Vault with versioning and "comments required" creating
an object outside a sequence did not require a comment.

CM7-22293

Sequence Data Audit Trail: Changing the order of the table columns of the injection list
directly after creation of the sequence added a spurious "Table Columns" node to the
data audit trail.

CM7-22294

Console - Import/Export: When a user attempted to import a sequence containing a
spectral library from Chromeleon 6 to Chromeleon 7.2, Chromeleon 7.2 would throw an
exception error.

CM7-22297

Console - Data Audit Trail: Changing the order of Sequence table columns after
performing Station Operational Qualification would result in changes to hidden
columns being reported in the Data Audit Trail.

CM7-22300

Console - Sequence Editor - Result Formula: The report variable injection.levelCheck
always returned n.a. when used in a result formula.

CM7-22327

Compliance - Spectral Libraries: Even though administrative settings are set to require
comment when creating a Spectral Library, a comment dialogue was not available when
creating and saving a new Spectral Library from the Console's Create menu.

CM7-22328

MS Fixed Calibration Performance: Injections used for fixed calibration with MS were
not written to the chromatogram cache so that results had to be recalculated whenever
accessed causing extra delays.

CM7-22382

Console - Sequence Editor: When editing a cell in the Injection List changes were only
applied after moving the cursor out of this cell.

CM7-22394

Services - General: Sequences would sometimes stop with the error "Data Vault Service
is not available" and a corresponding .NET Runtime error with ID 1023 in the Windows
Application Event Log.

CM7-22413

Console - Injection Query: When selecting any variable associated with Date&Time for
Sequence/Injection and "is empty" or "is not empty" for comparison an error indicator
"Invalid date/time value" next to the comparison value was displayed and the Injection
Query could not be executed.

CM7-22415

Data Audit Trail: When using the data audit trial to show changes between versions for
a chromatogram change of an MS channel, a GUID (alphanumeric string) was displayed
instead of the component trace name.

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CM7-22442

Administration Console - Scheduler: Sometimes completed Sequences would not get
removed from the queue and the Instrument Audit Trail would report the error "The
upload of the sequence "" failed. Error detail: At least one action of
the task failed."

CM7-22447

Setup and IQ: Following an upgrade of Chromeleon, the IQ could incorrectly report an
error in the timestamp of the InstrumentConfiguration_EN.CHM file.

CM7-22449

Network Data Acquisition: When an IPC running a sequence lost its network connection
to the Chromeleon domain, clicking on a remote data vault generated an “Unexpected
Error” message. Afterwards, the Console pane containing the data vault tree would
crash.

CM7-22457

Services - Discovery: Polling for data could result in larger amounts of data than optimal
being transferred over the network.

CM7-22474

Data Audit Trail Report: The Data Audit Trail Report generated an exception when there
was a report with a line object included contained in the data.

CM7-22476

Studio - Report Designer: Chromeleon allowed for empty cells of protected sheets in
the report designer to be formatted.

CM7-22484

Console - Import/Export: Importing a CMBX file which had been created with the
"Include 3D and MS data" option unticked could result in an error being displayed in
Chromeleon due to the presence of references to the excluded 3D or MS data.

CM7-22498

Console - Import/Export: When attempting to restore a CMBX which contained invalid
linked objects, instead of skipping the invalid objects, Chromeleon would report an
unhandled exception.

CM7-22511

Studio Performance: Changing between injections with many channels including nonevaluation channels was very slow.

CM7-22520

Administration Console - License Manager: The Chromeleon License Service performed
more read/writes to the License.xml file than was necessary, especially on larger
systems with many IPCs, and could have had a performance impact.

CM7-22528

Services - General: Following a reboot on some systems, the Chromeleon 7 Scheduler
Service would sometimes fail to start due to timeouts in services on which the
Scheduler depends (Chromeleon 7 Data Vault Service and Chromeleon 7 Discovery
Service).

CM7-22533

Studio - Performance: If a network sequence is modified mid-run without saving and
the completed sequence is uploaded, reloading the sequence results in the studio
hanging for an extended period of time.

CM7-22534

ICS-5000: Selecting the Gold, pH-Ag-AgCl RE, AAA waveform in the device sub-panel for
the ED detector would load the incorrect waveform parameters.

CM7-22546

Instrument Audit Trail: The instrument audit trail title bar displayed the date of the last
audit trail entry instead of the date of the first audit trail entry.

CM7-22600

Console: Occasionally, when copying multiple sequences, an 'invalid operation'
exception error would occur.

CM7-22620

Electronic Signature: It was not possible to submit a sequence containing cached Non
Targeted MS results.

CM7-22629

Data Audit Trail - Non Targeted MS Processing: In some instances, saving non targeted
MS processing results resulted in a spurious entry for an unnamed object without an
operation.

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CM7-22660

Instrument Audit Trail: On the ‘Historical’ tab of the instrument audit trail table, if an
audit trial in the selected date range failed an integrity check, the error message was
misleading. Depending on circumstances, it was either a generic message formatted as
a normal audit trail entry or implied that the audit trail was empty.

CM7-22663

Instrument/Injection Audit Trail: If an instrument or injection audit trail failed an
integrity check, it was still possible to create a report of the audit trail, but it did not
indicate that there was a problem with the audit trail.

CM7-22674

Services Manager: The polling interval of the Chromeleon Services Manager, when
minimized in the Windows System Tray/Windows Notification Area, was more frequent
than necessary which, on large systems, created unnecessary network traffic.

CM7-22675

Console - Sequence Editor: When trying to change the channel to be displayed in the
Injection List depending on the number of channels and injections it took several
seconds until the drop-down menu for the is shown.

CM7-22676

OQ/PQ: Running Station Operational Qualification on a computer which is part of a
Chromeleon domain, but is not currently connected to the Chromeleon Domain
Controller would incorrectly result in a "Timeout during initialization of instrument"
failure.

CM7-22696

Agilent LC (ICF): When running a sequence with overlapped injections and using the
option to extract the injection volume from the method, it was possible that the
injection volume from the sequence was shown in reports.

CM7-22702

Reporting: When reporting gradient values for non-linear gradients, the audit trail
report variables would use an incorrect curve description for interpolation. This
affected reporting only, and not execution of the gradients.

CM7-22703

Studio - Processing Method: When using the 'Import Compound Data' function to
search MS peaks against a NIST library, clicking the ‘Select All’ button followed by the
‘Import’ button generated an error.

CM7-22709

Administration Console - Discovery: Performing a right-mouse click on a grouped
header in a number of Administration Console grids could result in an "Object not set to
an instance of an object" error message being displayed.

CM7-22713

Data Acquisition: Under rare circumstances, the Instrument Queue was aborted with a
"Collection was modified; enumeration operation may not execute." Error.

CM7-22718

Administration Console - Discovery: Some columns in the Data Vault properties grid
were inconsistent in their description of the Disabled/Enabled state of properties.

CM7-22720

OQ/PQ: Attempting to unlock a client session where Station PQ was running would
cause the error message "This account does not have the privileges required to unlock
the console." even when the user account did have the necessary 'Close Locked Clients'
privilege.

CM7-22731

OQ/PQ: Running Station Performance Qualification could cause a memory leak, which
could then result in "out of memory" errors when subsequently working with
Chromeleon.

CM7-22742

Instrument Queue - Print & Export Settings: When changing the Print & Export Settings
in the Queue these settings are not reflected consistently in detached and integrated
ePanels. The settings are also not preserved when restarting the Console.

CM7-22744

Console - Import/Export: The CMBX comment field should only accept 255 characters.
Chromeleon did not prevent >255 characters being entered in the comments field, and
this would cause the export to CMBX to fail and an error message would be raised.

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CM7-22745

Console - Import/Export: Comments entered in the Send To dialog when creating a
CMBX were not saved to the CMBX and were therefore not visible when the CMBX was
imported.

CM7-22755

Data Audit Trail - Injection Record: When creating a new injection, a record for creation
and change of the injection were created in the data audit trail, resulting in confusion.

CM7-22770

Administration Console - Scheduler: Performing Save As with raw data on a currentlyacquiring Sequence would cause a System.NullReferenceException. Save As, Copy and
Paste, and Drag and Drop are all now prevented for acquiring Sequences.

CM7-22772

Console - Data: In some instances, copying a running sequence resulted in the running
injection status being changed to idle but containing raw data which could not be
overwritten in the newly created sequence.

CM7-22774

Console - Instrument Queue: Adding a Sequence to an instrument queue could result in
an error "The sequence  does not exist." being displayed, especially when
adding multiple Sequences in a short period of time, or if the sequence(s) contain a
large number(s) of injections.

CM7-22794

Studio - Electronic Report: When creating an electronic report during data acquisition,
Chromeleon would throw an error.

CM7-22812

Console - Data: When copying a running injection with raw data into another sequence,
the run state was also copied over, resulting in an injection that could not be changed
or deleted.

CM7-22824

Studio - Processing Method: When changing the properties of a calibration, it was
possible to edit the Relative Response Factor, even when not using calibration of
another component.

CM7-22875

Console - Sequence Editor: In some instances, saving an existing sequence resulted in
added or deleted injections not being reflected in the UI without a refresh.

CM7-22876

Studio - MS Components View: When a component had a quantitation and
confirmation peaks, the quantitation peak was sometimes mislabeled as the incorrect
transition.

CM7-22884

Console - Import/Export: Data imported from Agilent ChemStation, on a pre-7.2 SR5
client, showed two errors: (i) the x-axis (Wavelength) was incorrectly labelled as ms
instead of nm, and (ii) the data range minimum was always shown as 0.

CM7-22917

Console - Import/Export: Exporting large sequences to .cmbx could be very slow and
the progress bar would appear to be 'stuck' at 100% while post-export checks were
performed.

CM7-22920

Data Vault Manager: Data Vault Manager did not prevent the renaming of read-only
Data Vaults.

CM7-22979

Data Vault Manager: Attempting to dismount a Data Vault which has been marked as
Read-Only would result in an error message, and it would not then be possible to
mount the Data Vault on a different Data Vault Server.

CM7-22988

Agilent 6890/7890 GC: In Constant Flow mode, the Inlet and Columns ePanel displayed
the nominal flow value, even though it wasn’t applicable. A similar problem also existed
for Constant Pressure mode

CM7-22991

Console - Import/Export: Sequences generated using eWorkflows in Chromeleon 7.2
SR1 MUa could not be imported.

CM7-22999

Console - Data Audit Trail: Instrument Method Comparison report would sometimes
omit method changes under rare circumstances.

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CM7-23014

Console - Sequence Editor: When updating the next injection of a running sequence,
although the changes can be saved, when the next injection starts, sometimes the
sequence was aborted with an error “The running or preparing injection cannot be
saved… because it was changed by a different user since it was loaded”.

CM7-23037

Administration Console - Scheduler: Attempting to import Chromeleon 6 sequences
could sometimes result in a "the handle is invalid" error message and the data would
not be imported.

CM7-23038

Administration Console - Scheduler: Attempting to import Chromeleon 6 sequences
containing spectra fields with less than 2 spectra result in a "the transaction has
aborted" error message and the data would not be imported.

CM7-23079

Fraction Collection: When the 'collect outside peaks' option was selected, fraction
collection continued even after the collection time window completed.

CM7-23133

Console - Import/Export: A defect in Chromeleon 6 allowed control characters (e.g. \n
for line feed, or \r for carriage return) to be pasted into text fields. If a Sequence
containing these characters in any grid was then imported into Chromeleon 7, the
import would fail with a 'Fatal' error which stated that it contained text which was
"invalid for this item type".

CM7-23134

Administration Console - Scheduler: Copying Chromeleon 6 Sequences into Chromeleon
7 using a Scheduler task would fail for any Sequences with verified Chromeleon 6
Electronic Signatures.

CM7-23163

A2D: When using a USB3 port in Windows 8 to download firmware to the A2D V4, an
"Invalid Configuration Descriptor" error occurred.

CM7-23180

Reporting - Instrument Method Overview Table: In a report template for a sequence
using multiple instrument methods, the Instrument Method Overview Table reports
information for only the first injection when used on any report sheet except the first
sheet.

CM7-23199

Reporting: When opening a Report Template from the Associated Items list in the
console, the user would not receive prompt feedback that the item was opening.

CM7-23225

Console - Import/Export: Attempting to export to .cmbx a Sequence containing
subfolders, would result in Chromeleon reporting an 'unexpected error' if any of the
subfolders had access restriction defined.

CM7-23263

TSQ 8000: When a Thermo Scientific TSQ 8000 is acquiring data, a sequence would stall
indefinitely between injections in some situations.

CM7-23300

Console - Import/Export: When exporting a Sequence containing subfolders to .cmbx, if
any of the subfolders had access restriction defined, it was possible, under certain
circumstances, for users without the required 'Send to File' privilege to export
restricted subfolders.

CM7-23361

Integrion: Closing the column compartment and/or detector doors just before starting
or during a running sequence would cause the approved consumables to go into an
unapproved state if one of those consumables is dropped from the scan (e.g., if tag is
misaligned). This would abort said sequence.

CM7-23380

EG-5000: In very rare cases, a pump leak or pressure over limit error would not turn off
the EGC.

CM7-4134

Studio - Peak Properties Pane: The Undo / Redo did not work when making changes to
the component table using the peak properties pane.

CM7-6390

ePanels - UltiMate DGP-3600(RS, SD): When using an UltiMate DGP-3600(RS, SD)
shared between two instruments, the ePanels would show only the left pump on both
instruments, in addition to some $1 symbols.

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CM7-8121

Data Vault Manager: When creating or mounting a multi-user data vault via the
respective wizards the password of the user used for authentication was shown as plain
text in the Connection string edit box. The password is now obfuscated and not visible
unless the password is edited directly into the connection string.

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6 Backward/Forward Compatibility Issues
6.1 Thermo Scientific Vanquish Charged Aerosol Detector [CM6-23499]
Any Instrument Methods created for the Vanquish Charged Aerosol detector with Chromeleon 7.2
SR2 MUa and earlier may need to be updated due to changes in the driver introduced in Chromeleon
7.2 SR2 MUb.

6.2 Thermo Scientific Vanquish Autosampler [CM6-23405]
Any Instrument Methods created for the Vanquish Autosampler containing the WashSpeed property
will need to be updated. The WashSpeed value needs to be divided by 0.06 in order for the
Instrument Method to work correctly.

6.3 Thermo Scientific TriPlus RSH
The updated driver for this instrument is incompatible with firmware older than version 2.2.
Note: It is necessary that the firmware is updated to the latest version in order to benefit from
any future driver enhancements.

6.4 Thermo Scientific TriPlus 300 HS [CM6-22430]
The updated driver for this instrument is incompatible with firmware older than 2001.9.0.
Note: It is necessary that the firmware is updated to the latest version in order to benefit from
any future driver enhancements.

6.5 Thermo Scientific TriPlus LS-100
The updated driver for this instrument, included in this Service Release, is incompatible with
firmware older than version 2.2.
Note: It is necessary that the firmware be updated to the latest version in order to control the
instrument with this software release.

6.6 Thermo Scientific TSQ Quantiva
The driver version 1.1 QF1 for this instrument, included in this Service Release, may not be
compatible with existing TSQ Quantiva mass spectrometers running driver version 1.0 without a
hardware update. Please contact your local MS service engineer before attempting to upgrade the
unit.

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Note: New TSQ Quantiva modules from the factory are not affected by this issue.

6.7 Thermo Scientific TSQ Quantiva and Endura
The driver version 1.1 SP1 for these instruments may not be compatible with existing TSQ Quantiva
and Endura mass spectrometers running driver version 1.0 without a hardware update. Please
contact your local MS field service engineer before attempting to upgrade the unit.
Note: New TSQ Quantiva and Endura modules from the factory are not affected by this issue.

6.8 TSQ Quantiva and Endura Instrument Method [CM7-18759]
Instrument methods created with older versions of the TSQ Quantiva and Endura instrument method
editor cannot be opened with newer versions of the method editor. If a large number of instrument
methods have already been created for regular use, upgrade of the TSQ Quantiva and Endura driver
is not recommended. Contact your local Thermo Fisher Scientific representative for additional
details.

6.9 Signed Sequences [CM7-16374]
Sequences that have been signed within Chromeleon 7.2 SR1 will fail verification after copying within
later versions of Chromeleon 7.2 CDS.

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7 Appendix
This chapter contains general Information about Service Releases, Release Notes, Online Help, and
Contributed Content.

7.1 Release Notes
The Release Notes list the new features and improvements of the current release. Included in these
Release Notes are all of the functionality and bug fixes from Chromeleon 7.2 SR4 MUa and
Chromeleon 7.2 SR4 MUb. For details about Chromeleon 7.2 SR4 and other previous releases, refer
to the relevant release notes which can be found on the Chromeleon 7.2 SR5 DVD.

7.2 Online Help
In general, new features, updates and drivers that are introduced with this release are described in
an updated Online Help that is distributed with the release.

7.3 Contributed Content
The Chromeleon 7 disk contains a folder titled Contributed Content. This folder contains:
•

Demonstration Material

•

Localized Documents

•

Localized ePanels

•

Localized Report Templates

•

eWorkflow Templates

•

User Management Example

•

Charlie Mouse Pointer
Note: The files in the Contributed Content folder have not been tested and validated according to
Thermo Fisher Scientific Software Development Cycle guidelines modeled after ISO 9001:2008
standards. Thermo Fisher Scientific assumes no responsibility for any errors that may appear in
the content provided in the Contributed Content folder.

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