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PDF 744866 80 en-US GHS

Safety Data Sheet
SDS acc. Hazard Communication Standard

REF: 744866.80 Printing Date: 28.05.2020

Buffer MV1 (80 mL) Date of Issue: 05.06.2018

Section 1: Identification

1.1

Product Identifier / Product Name

REF Product Name -

744866.80 Buffer MV1 (80 mL)
1 x 80 mL MV1

1.2

Relevant identified Uses of the Substance or Mixture and Uses advised against

Relevant identified uses Product for Analytical Use.
The Exposure scenario is integrated into sections 1-16. Uses advised against not described

1.3

Details of the Supplier and of the Safety Data Sheet

Manufactured by: MACHEREY-NAGEL GmbH & Co. KG Neumann-Neander-Str. 6-8, 52355 Dueren, GERMANY Tel.: +49 2421 969 0

E-mail: sds@mn-net.com (msds@mn-net.com)

1.4

Emergency Telephone Number

For Chemical Emergency

Spill, Leak, Fire, Exposure, or Accident

Call CHEMTREC Day or Night

(CCN685047)

Within USA and Canada:

1-800-424-9300

Outside USA and Canada:

+1 703-527-3887 (collect calls accepted)

You find our current versions of SDS (22 languages) in Internet:

http://www.mn-net.com/SDS

Section 2: Hazard(s) Identification

2.1

Classification of the Substance(s) or Mixture(s)

80 mL MV1

Page: 1/7

Signal Word
Hazard Identification
H302 H312 H315 H319 H412

GHS07
WARNING
Hazard Classes/Categories
Acute Tox. 4 oral Acute Tox. 4 derm. Skin Irrit. 2 Eye Irrit. 2 Aquatic Chronic 3

2.2

Safety, Health and Environmental Regulations/Legislation specific for the Substance or Mixture

According the implementation of GHS immediate packages only must be labelled with product identificator(s), GHS symbol(s), signal word, manufacturer name and phone number (OSHA's interpretation of HCS 2012).

Harmful chemicals/mixtures with signal word: WARNING must not be labelled with H and P phrases until 125 mL (EU 1272/2008 Annex I - 1.5.2) / until 100 mL (Canada WHMIS 2015). This labelling exemption does not apply to U.S.A.
80 mL MV1

Version: M V 4.10.1

Safety Data Sheet
SDS acc. Hazard Communication Standard

REF: 744866.80 Printing Date: 28.05.2020

Buffer MV1 (80 mL) Date of Issue: 05.06.2018

Page: 2/7

GHS07 Signal Word: WARNING

2.3

Other Hazards

Possible Hazards from physicochemical Properties In the case of pH values are less than 5 or higher than 9 then it is irritant. For guanidine thiocyanate CAS 593-84-0: The properties H314, H332 «Causes severe skin burns and eye damage. Harmful if inhaled.» are not relevant, because the mixture solution is buffered to pH 4-9. ---
Information pertaining to particular Risks to Human and possible Symptoms Cause after oral intake, inhalation of vapors/dust, impairments of health when ingested in small quantities. ---
Information pertaining to particular Risks to the Environment ---
Other Hazards ---

Section 3: Composition/Information on Ingredients

3.1

Substances or 3.2 Mixtures

80 mL MV1

Chemical: guanidinium thiocyanate

CAS No.: 593-84-0

Classification:

H302, Acute Tox. 4 oral, H312, Acute Tox. 4 derm., H314, Skin Corr. 1B, H332, Acute Tox. 4 inh.,

H412, Aquatic Chronic 3

Chemical Formula: C2 H6 N4 S

Synonyms:

guanidine rhodanide

TSCA Inventory: listed

RTECS:

XL1225000

MFCD:

00013027

EC No.:

209-812-1

Indice No.:

615-004-00-3

Weight Percent:

60 - <80 %

acc. GHS:

H302, Acute Tox. 4 oral, H312, Acute Tox. 4 derm., H315, Skin Irrit. 2, H319, Eye Irrit. 2, H412,

Aquatic Chronic 3

3.3

Remarks

When not listed, mixtures are added with water [CAS No. 7732-18-5] to 100%.

List of Hazard and Precaution phrases: see section 16.1

Section 4: First-Aid Measures

4.1
4.1.1 4.1.2 4.1.3 4.1.4

Description of First-Aid Measures
Place insured person out of danger zone to fresh air immediately. Ensure quiet, warmth, and provide resuscitation if necessary. If necessary contact medical advice.
After SKIN Contact Remove contaminated clothing. Rinse the affected skin or mucous membrane thoroughly under running water. (If possible) use soap.
After EYE Contact After contact with the eyes rinse thoroughly under running water with the eyelid wide open with eye washing bottle, eye douche or running water (protect intact eye).
After INHALATION of Vapors After inhalation of foam or vapor fresh air should be inhaled. Keep airways free.
After ORAL Intake After oral intake lots of water should be drunk after it has been ingested.

Version: M V 4.10.1

Safety Data Sheet
SDS acc. Hazard Communication Standard

REF: 744866.80 Printing Date: 28.05.2020

Buffer MV1 (80 mL) Date of Issue: 05.06.2018

Page: 3/7

4.2

Most important Symptoms and Effects, both acute and delayed

---

4.3

Indication of any immediate Medical Attention and Special Treatment needed

No additionally recommendations. ---

Section 5: Fire-Fighting Measures

5.1

Extinguishable Media

Fire extinguishers appropriate to the fire classification, and, if applicable, a fire blanket must be available in a prominent location in the work area. All extinguishers like WATER FOG, WATER SPRAY, alcohol-resistant FOAM, DRY CHEMICAL, CARBON DIOXIDE can be used.

5.2

Special Hazards arising from the Substance or Mixture

Formation of hazardous and caustic vapor-air mixtures possible. ---

5.3

Advice for Firefighters

No, for listed product. Product package burns like paper or plastic.

5.4

Additional Information

---

Section 6: Accidental Release Measures

6.1

Personal Precautions, Protective Equipment and Emergency Procedure

Do not breathe vapors. Regular staff training is necessary.

6.2

Environmental Precautions

not necessary, contains only small amounts of these substances

6.3

Methods and Material for Containment and Cleaning up

Bind any escaping liquid with inert absorbent. Collect small amounts of leaked liquid and flush with water into sewer.

6.4

Reference to other Sections

---

Section 7: Handling and Storage

7.1 7.2
7.2.1
7.3

Precautions for Safe Handling
Handling in accordance with the test instruction, that comes with the product.

Conditions for Safe Storage, including any Incompatibilities

The original product package of MACHEREY-NAGEL allows a safe storage.

Storage class (VCI):

Water hazard class (DE):

Conditions for Safe Storage, including any Incompatibilities Keep original product packages tightly closed during handling and storage.

Specific End Use(s)
Product for analytical use.

Section 8: Exposure Controls/Personal Protection

8.1

Control Parameters

80 mL MV1

Chemical: guanidinium thiocyanate

DNEL:

[inh] 1092 µg/m³

DNEL = Derived No-Effect Level (for workers)

CAS No.: 593-84-0

PNEC(fresh water) :

42.4 µg/L

PNEC = Predicted No Effected Concentration

NIOSH:

not listed

[TWA] Time-weighted average to a reference period of 8 hours, [STEL] Short-term exposure limit related to a 15-minute period

OSHA:

not listed

Version: M V 4.10.1

Safety Data Sheet
SDS acc. Hazard Communication Standard

REF: 744866.80 Printing Date: 28.05.2020

Buffer MV1 (80 mL) Date of Issue: 05.06.2018

Page: 4/7

8.2
8.2.1 8.2.2 8.2.3 8.2.4 8.2.5

Exposure Controls
Good ventilation and extraction system in the room, floor resistant to chemicals with floor drainage and washing facilities. The highest level of cleanliness must be maintained at the workplace.
Respiratory Protection No additional recommendations.
Hand Protection Yes, gloves (permeation time >30 min - level 2), consist of PVC.
Eye/Face Protection Yes, Splash Goggles.
Skin Protection Not necessary.
Hygiene Measures Eating, drinking, smoking, taking snuff and storage of food in work areas and at outdoor workplaces is prohibited. Avoid contact with the skin, eyes and clothing. Rinse any clothing on which the substance has been spilled, and soak it in water. Wash hands thoroughly with soap and water when stopping work and before eating, and then apply protective skin cream.

Section 9: Physical and Chemical Properties

9.1

Information on Basic Physical and Chemical Properties

80 mL MV1

a) Appearance: liquid

Color: colorless

c) Odor Threshold:

data not available

d) pH:

5.5-6

e) Melting Point:

data not available

Boiling Point:

data not available

g) Flash Point:

data not available

Evaporation Rate(ether=1) : data not available

Flammability (solid, gas): data not available

Explosive Limits:

data not available

k) Vapor Pressure (68°F):

data not available

Vapor Density(air=1) :

data not available

m) Specific Gravity:

1.15 g/cm³

n) Soluble in Water:

data not available

Partition Coefficient (o-w): data not available

Autoignition Temperature: data not available

Decomposition temperature: data not available

Viscosity:

data not available

s) Explosive properties:

data not available

Oxidizing properties:

---

b) Odor: fusty, mouldy

9.2

Other Information

Data for the other parameters of the mixtures are not available. Relevant Properties of Substance Group ---

Section 10: Stability and Reactivity

10.1 10.2 10.3 10.4 10.5

Reactivity
No further data available.
Chemical Stability
No known instability.
Possibility of Hazardous Reactions
Can form very reactive substances with oxidizing agents. Possibility: Contact with acids liberates toxic gas. No further data available.
Conditions to avoid
---
Incompatible Materials

Version: M V 4.10.1

Safety Data Sheet
SDS acc. Hazard Communication Standard

REF: 744866.80 Printing Date: 28.05.2020

Buffer MV1 (80 mL) Date of Issue: 05.06.2018

Page: 5/7

10.6

Not necessary. Avoid contact with strong acids or alkalines. ---
Hazardous Decomposition Products
In the original package all parts/all reagents are safety and separated stored. Decompositions are not observed during the expiration period under recommended conditions.

Section 11: Toxicological Information

11.1

Information on Toxicological Effects

Following information is valid for pure chemicals. Quantitative data on the toxicity of this product are not available.

80 mL MV1

Chemical:

guanidinium thiocyanate

CAS No.: 593-84-0

TSCA Inventory:

listed

California Prop. 65 List: not listed

Canada CEPA 1999:

DSL yes

LD50orl rat :

593 mg/kg

LC50drm rbt :

>2000 mg/m³

LC50ihl rat :

[4h] 5.319 mg/L

LD50ipr mus :

300 mg/kg

Acute Effects: Cause after oral intake, inhalation of vapors/dust, impairments of health when ingested in small quantities.

Section 12: Ecological Information

12.1

Toxicity
Following information is valid for pure chemicals.

80 mL MV1

Chemical:

guanidinium thiocyanate

CAS No.: 593-84-0

Harmful to aquatic life with long lasting effects. Avoid contact of chemical/mixture to environment.

Environmental hazards must not be labelled with P phrases until 125 mL (EU-CLP 1272/2008 Annex I - 1.5.2).

PNEC(fresh water) :

42.4 µg/L

PNEC = Predicted No Effected Concentration

LC50fish/96h : EC50daphnia/48h : IC50scenedesmus quadricauda/72h : EC10pseudomonas putita/16h : Partition Coefficient (o-w):

[4d] 89.1 mg/L 42.4 mg/L 130 mg/L [10d] 200 mg/L [pH 5.1] -1.11

12.2 12.3 12.4 12.5 12.6

Persistence and Degradability
not necessary
Bioaccumulative Potential
not necessary
Mobility in Soil
not necessary
Results of PBT and vPvB Assessment
no data available
Other Adverse Effects
no additional data available

Section 13: Disposal Considerations

Do not collect in acidic waste. May form toxic gases. Please observe local regulations for collection and disposal of hazardous waste and contact waste disposal company, where you will obtain information on laboratory waste disposal (RCRA Code D002/D003, EU waste code number 16 05 06).

13.1

Waste Treatment Methods
Normally it is possible to empty small amounts (diluted!) into drains.

Version: M V 4.10.1

Safety Data Sheet
SDS acc. Hazard Communication Standard

REF: 744866.80 Printing Date: 28.05.2020

Buffer MV1 (80 mL) Date of Issue: 05.06.2018

Section 14: Transport Information

14.1 - 14.4: No dangerous goods according the Transport regulations

14.5

Environmental Hazards
none, contains only small quantities of hazardous substances, contains only small amounts of these substances

14.6

Special Precautions for User
not necessary

14.7

Transport in Bulk according to Annex II of MARPOL and the IBC Code
not applicable

Page: 6/7

Section 15: Regulatory Information

15.1

Safety, Health and Environmental Regulations/Legislation specific for the Substance or Mixture
U.S. Federal Regulations OSHA "A Guide to The Globally Harmonized System of Classification and Labelling of Chemicals (GHS)" https://www.osha.gov/dsg/hazcom/ghs.html 29 CFR 1910.1200 Hazard communication. NIOSH Pocket Guide to Chemical Hazards NIOSH Workplace Safety & Health Topics TSCA Inventory U.S. State Regulations California Prop 65, Safe Drinking Water and Toxic Enforcement Act of 1986 Canada Canada CEPA 1999 - Domestic Substances List (DSL), List of Toxic Substances (Schedule 1)

15.2

MN Leaflet/User manual, also see www.mn-net.com
Chemical Safety Assessment
not necessary for these small amounts ---

Section 16: Other Information

16.1
16.1.1
16.1.2
16.2 16.3 16.4

List of Hazard and Precaution Phrases

List of relevant H Phrases

H302

Harmful if swallowed.

H312

Harmful in contact with skin.

H315

Causes skin irritation.

H319

Causes serious eye irritation.

H412

Harmful to aquatic life with long lasting effects.

List of relevant P Phrases

P264W

Wash with water thoroughly after handling.

P273

Avoid release to the environment.

P280sh

Wear protective gloves/eye protection.

P301+312

IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell.

P302+352

IF ON SKIN: Wash with plenty of water.

P330

Rinse mouth.

Training Advice

Regular safety training.

Recommended Restriction on Use
Only for Professional User. An individual package of this product or test kit has a moderate hazardous potential.

Further Information

MACHEREY-NAGEL GmbH & Co. KG provides the information contained herein in good faith being up-to-date of own realizations at revision time. This document is intended only as a guide to the appropriate precautionary handling of the material by a properly trained person using this product. Individuals receiving the information must exercise their independent judgement in determining its appropriateness for a particular purpose. MACHEREY-NAGEL GmbH & Co. KG makes NO REPRESENTATIONS or WARRANTIES, either expressed or implied, including without limitation any warranties of merchantability, fitness for a particular purpose with respect to the information set forth herein or the product to which the information refers. Accordingly MACHEREY-NAGEL GmbH & Co. KG will not be responsible for damages resulting from use of or reliance upon this information. See terms and conditions at the end of our price lists for additional information.

Version: M V 4.10.1

Safety Data Sheet
SDS acc. Hazard Communication Standard

REF: 744866.80 Printing Date: 28.05.2020

Buffer MV1 (80 mL) Date of Issue: 05.06.2018

Page: 7/7

16.5

Sources of Key Data
GHS: EU Regulation 1272/2008/EC on Classification, Labelling and Packaging of Substances and Mixtures, amending and repealing EU Directives 67/548/EEC and 1999/45/EC, and amending EU Regulation 1907/2006/EC SDS: EU Regulation 453/2010/EU REACH - Requirements for the Compilation of Safety Data Sheets KÜHN, BIRETT (German), Data Sheets of Hazardous Substances

Revisions/Updates Reason for Revision: 2016-03 Adaptation of European Regulation 1221/2015/EU

You find our current Versions of SDS in Internet: http://www.mn-net.com/SDS [U.S. English]

Version: M V 4.10.1

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