DHM Allergy(2010)

User Manual: DHM

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TESTS FOR ALLERGY
NEW TECHNOLOGY
In August 2009 we commissioned new allergy test systems that further extend our testing menu. Our new technology
detects Specific IgE to clinically important individual allergen molecules. We continue to offer testing for allergens to
whole food and inhalant allergens. The main analyser platforms and reagent systems are the Phadia ImmunoCAP 250,
ImmunoCAP 1000 and ISAC ImmunoCAP. Our comprehensive menu is included in this brochure. You may request the
allergens using their alphanumeric codes. Please precede these codes with “Specific IgE for”, or “Allergy serology for”,
or “RAST for”.

Dear Colleague,
Welcome to our new Allergy Test Menu, one
of the largest internationally available allergy
testing menus. All our specific IgE testing is
now performed on the Phadia ImmunoCAP
250 and Phadia ImmunoCAP 1000 system
(pages 3-10). An advantage of the Phadia
ImmunoCAP system is that, for certain key
foods, the 95% probability of a positive
food challenge has been determined for
certain levels of allergen-specific IgE (see
Table below). We will continue to report

allergen specific IgE values in kU/L and a
semiquantitative class value. Please note
that some patients with a “negative” or “0”
class may have detectable traces of specific
IgE that can have clinical significance as
a marker of early sensitisation or previous
significant sensitisation to insect venoms
and drugs. In the most important practical
advance in laboratory allergy diagnostics,
the Phadia ImmunoCAP ISAC system now
allows us to determine a patient’s specific IgE
to 103 clinically important allergen molecules
from 47 different allergens. Tests that define
the molecule in a food to which a patient
has significant specific IgE, can provide
diagnostic and prognostic information
for patients with serious food allergy. Our
new technology allows us to do this with
recombinant ImmunoCAP allergens (page
10) or as a profile with the ISAC system
(page 11). We continue to offer other tests
important for assessing allergy problems:
Total IgE, Tryptase, Eosinophilic Cationic
Protein (ECP), C1 esterase and genetic
testing for Hereditary Angioedema Types I, II
and III (see next page).
We have always taken the view that we

ALLERGEN SPECIFIC IgE

kU/L

PPV

Egg (<= 2yo)

2

95%

Egg (> 2yo)

7

98%

Milk (<=2 yo)

5

95%

Milk (>2 yo)

15

95%

Peanut

14

100%

Fish
Tree nuts
Wheat

Please send email enquiries to
kbaumgart@dhm.com.au or
Phone: 02 98 555 286
Karl W Baumgart
Director, Immunology

ORDERING ALLERGY TESTS

Specific IgE Levels Conferring Very High Risk
ALLERGEN

should offer the best available allergy testing
systems and give patients the opportunity
to cover the cost of more definitive higher
quality testing that the government will not
meet. In May 2009, the Medicare Benefits
Schedule reduced rebates for Allergy
testing by 1%: a reimbursement that is now
less than 20% of rebates in comparable
countries for laboratory allergy testing. It
is almost impossible to answer a simple,
sensible laboratory allergy testing request
within the constraints of the level of Medicare
reimbursement. Consequently, the laboratory
is unable to accept Medicare reimbursement
for more than very basic allergy testing
requests. In this menu, we seek to give
your patients clear options and choices
when it comes to allergy testing. You and
your patients will be pleased to know that
although some new allergens and mixes are
more expensive, core individual allergens and
extended panels are cheaper than previously.

20

100%

~15

~95%

26

74%

This table was derived from several large studies in which
patients were challenged with the food. The positive predictive
value (PPV) of a specific IgE level for a positive challenge
was determined. It illustrates that specific IgE levels for
individual allergens are like “international currencies” and are
not necessarily comparable for a particular level for all the
allergens. It defines levels at which a challenge, or exposure,
would be highly hazardous for a patient. Importantly, many
patients could have serious reactions at much lower levels.

We ask that you specifically nominate which allergens you
would like tested. Please do not write the allergens to be
tested in the clinical notes section of the request form. A
comprehensive menu of allergens that we stock and test for
is available in the following pages. If allergens are not available
we may use cross-reactive ones or advise you on the report.
Some “allergy symptoms” may result from intolerance
mechanisms (salicylates, amines, MSG, metabisulphite)
and detection of IgE to them is not useful or possible. You
can request the allergens using their alphanumeric codes.
To assist staff performing data entry, we appreciate it if you
precede these codes by “Specific IgE for” or “Allergy serology
for” or “RAST for”.
If you simply write “RAST” we will now test as follows:
Child 6 years or less: dust mite, egg white, cow’s milk,
peanut and soy (Panel A1)
Adult or child over 6 years: dust mite, cat, dog, grass pollen
and alternaria (Panel A2)
If you write “food and inhalant allergens”, we will test a staple
food mix (Fx5, that includes egg white, cow’s milk, peanut,
soy, wheat and codfish), dust mite, fescue grass pollen-which
cross-reacts with almost all other grasses and, alternaria-an
outdoor mould with small spores that can easily be inhaled
into the small airways (Panel A16). We do recommend some
extended panels of individual allergens and can specifically
design panels for you and your patients.

OTHER COMMON INITIAL INVESTIGATION PANELS

TOTAL IgE

* Please write the name and code of the panel on the request form.

One (1) of our panels is within our allowance under Medicare

Normal total IgE levels (< 100 kU/L) do not exclude significant allergies. Patients with normal total IgE levels can still be allergic to bee venom,
dustmite, and many other allergens.

A8 NATIVE TREES

A9 FOOD SCREEN

A10 NUTS

A11 SEAFOOD

Significant specific IgE levels are extraordinarily rare in individuals with total IgE values of less than 7 kU/L.

T18

Eucalyptus

FX1

Nut Mix

F13

Peanut

F3

Codfish

Persons with very elevated total IgE levels are more likely to have significant elevations in specific IgE. Very elevated levels of total IgE also occur in
persons with severe eczema, helminthic and parasitic infestations as well as allergobronchopulmonary aspergillosis (ABPA). Monitoring total IgE levels
is useful in patients on immunosuppression for their severe eczema as well as in ABPA.

T19

Acacia

F23

Crab

F17

Hazelnut

F23

Crab

T21

Melaleuca

F4

Wheat

F20

Almond

F24

Prawn

T73

Australian Pine

F1

Egg

F201

Pecan nut

F80

Lobster

TRYPTASE
Elevated levels of mast cell tryptase in peripheral blood indicate systemic mast cell degranulation or an increased number of mast cells which can
occur in patients with mastocytosis.
Tryptase is NOT ELEVATED in persons with anaphylaxis from foods or non-parenteral agents.

A12 CEREALS

A13 STAPLE FOODS

A14 INSECTS

A15 LATEX & FOODS

F4

Wheat

F1

Egg white

I1

Honey bee venom

K82

Latex

F6

Barley

F2

Milk

I4

Paper wasp venom

F84

Kiwi fruit

F9

Rice

F13

Peanut

I3

Yellow Jacket

F87

Melon

F14

Soy

F14

Soybean

I70

Fire ant venom

F92

Banana

I71

Mosquito

D1

Dust Mite

M6

Alternaria

Elevated levels indicate an adverse reaction to a stinging insect or a reaction to an intravenous, intramuscular or subcutaneous diagnostic or
therapeutic agent. Any elevated tryptase levels should be repeated after a period of time (3-10 days) to document a return to normal levels.
Persistently elevated levels of tryptase are strongly suggestive of systemic mastocytosis which may not always manifest with urticaria pigmentosa.
Since mastocytosis is more common in persons with stinging insect reactions, persons who have had systemic reactions to stinging insects should
always have their tryptase level checked together with relevant venom specific IgE. The test is performed on serum. Normal values are < 13.5 ug/L.
For these indications, the test is Medicare rebatable.

A16 FOOD & INHALANTS
FX5

Staple Foods

G4

Grass Pollen (fescue)

A3 CHILD ALLERGY ASSESSMENT PANEL (REQUEST “IgE AND RAST A3”)

EOSINOPHILIC CATIONIC PROTEIN (ECP)
ECP is elevated in persons with active eosinophilic inflammation. It is a useful marker in the diagnosis and management of hypereosinophilic
disorders. ECP is also a useful marker of allergic airways inflammation in young children.

This new panel is designed for the assessment of children at high risk of allergic disease, especially those with eczema, possible food and inhalant allergies.
The cost of this panel is $108, for which a Medicare rebate of $22.95 may be available.

The test is performed on serum. Normal values for children are < 20 ug/L and adults < 15 ug/L.

D1

Dustmite

M6

Alternaria alternata

F202

Cashew

At present the test is only reimbursed by Medicare when requested in children under 12 years of age for assessment of airways inflammation (Please
write “asthma” on clinical notes). For all other requests, the fee is $50, non-rebatable.

E1

Cat Epithelium

F1

Egg White

F17

Hazelnut

E82

Rabbit Epithelium

F75

Egg Yolk

F35

Potato

E5

Dog

F2

Milk

F84

Kiwi Fruit

E3

Horse Dander

F3

Codfish

F91

Mango

G2

Bermuda Grass

F14

Soybean

F92

Banana

G4

Grass Pollen (fescue)

F4

Wheat

K82

Latex

G5

Perennial Rye Grass

F10

Sesame Seed

M80

Staph. Enterotoxin A

W21

Parietaria judaica

F13

Peanut

M70

Pityrosporum orbiculare

Type I & II (C1 ESTERASE INHIBITOR) HEREDITARY ANGIOEDEMA
This should be considered in anyone with a family history of angioedema without urticaria. C1 esterase level and function, C3 and C4 should be
measured at the same time to facilitate interpretation of the results. Abnormal levels occur in persons with deficiency which has autosomal dominant
inheritance. Persons with this disorder usually experience symptoms from puberty onwards and may have life-threatening episodes which are not
responsive to adrenaline. Many patients also experience recurrent abdominal pain due to visceral angioedema. Functional deficiency may occur on a
genetic basis or in older persons it can result from an interfering autoantibody associated with lymphoma. Abnormal functional assay results should
always be repeated.
The C3, C4, quantitative and functional C1-esterase (C1-inhibitor) assays are performed on serum and reimbursed by Medicare. Sequencing for the
detection of mutations causing Type I and II HAE is performed by the laboratory and the fee is $395 (non-rebatable).

EXTENDED ALLERGEN PANEL EXAMPLES
* Our charge for each of these panels is $80, for which a rebate of $22.95 may be available per episode. Each allergen may also be ordered separately by its
code or name. Other personalised extended panels are available on request. Please call Dr Karl Baumgart to discuss your requirements.

TYPE III (FACTOR XII) HEREDITARY ANGIOEDEMA
This should also be considered, mainly in women, who have angioedema without urticaria. Type III (Factor XII) Hereditary Angioedema is detected by
a real-time PCR assay which detects the most common mutation in Factor XII. This is a cause of angioedema without urticaria in women. This is the
only assay for this disorder which is thought to be at least as common as Type I and Type II HAE. At present there is a non-rebatable fee of $120.
The laboratory can also perform sequencing of Factor XII if required. The fee is $395 (non-rebatable).

INITIAL INVESTIGATION PANELS
If you write “RAST” or “Allergy serology”, but do not specify the allergens,
we will perform the tests listed under A1 (for a child 6 years or less) or
A2 (Adult, or child over 6 years). Any subsequently requested additional
allergens are charged according to the billing policy listed below.

A21 MOULD & STORAGE MITES

A22 FOODS

A23 ANAPHYLACTIC FOODS

D1

Dustmite

M1

Penicillium notatum

F1

Egg White

F3

Codfish

E1

Cat Epithelium

M2

Cladosporium herbarum

F2

Milk

F10

Sesame Seed

E5

Dog

M3

Aspergillus fumigatus

F3

Codfish

F13

Peanut

E3

Horse Dander

M4

Mucor racemosus

F4

Wheat

F17

Hazelnut

D201

Blomia tropicalis

M5

Candida albicans

F5

Rye

F18

Brazil Nut

A1: CHILD 6 years or less

A2: ADULT, or CHILD over 6 years

G2

Bermuda Grass

M6

Alternaria alternata

F6

Barley

F20

Almond

Total IgE

Total IgE

G4

Grass pollen (fescue)

M8

Helminthosporium

F9

Rice

F23

Crab

D1

Dustmite

D1

Dustmite

G5

Perennial Rye Grass

M9

Fusarium moniliforme

F10

Sesame Seed

F24

Prawn

F1

Egg white

G4

Grass pollen (Fescue)

E82

Rabbit Epithelium

M10

Stemphylium botryosum

F13

Peanut

F27

Beef

F2

Cow’s milk

E1

Cat

W1

Common Ragweed

M13

Phoma betae

F14

Soybean

F36

Coconut

F13

Peanut

E5

Dog

W9

English Plantain

M14

Epicoccum purpurascens

F17

Hazelnut

F40

Tuna

F14

Soy

M6

Alternaria

W10

Lamb’s Quarters

M15

Trichoderma viride

F20

Almond

F41

Salmon

W21

Parietaria judaica

M70

Pityrosporum orbiculare

F27

Beef

F80

Lobster

T18

Eucalyptus

D1

D. pteronyssinus

F33

Orange

F84

Kiwi Fruit

T19

Acacia

D70

Acarus siro

F35

Potato

F91

Mango

T21

Melaleuca

D71

Lepidoglyphus destructor

F44

Strawberry

F92

Banana

T73

Australian Pine

D72

Tyrophagus putrescentiae

F45

Yeast

F201

Pecan Nut

M2

Cladosporium herbarum

D73

Glycyphagus domesticus

F84

Kiwi Fruit

F256

Walnut

M3

Aspergillus fumigatus

D74

Euroglyphus maynei

F91

Mango

F290

Oyster

M6

Alternaria alternata

D201

Blomia tropicalis

F92

Banana

K82

Latex

OTHER COMMON INITIAL INVESTIGATION PANELS
* Please write the name and code of the panel on the request form.

2

A20 INHALANTS

One (1) of our panels is within our allowance under Medicare

A4 ANIMAL INHALANTS

A5 RURAL INHALANTS

A6 PETS

A7 MOULDS

E1

Cat

G17

Paspalum

E1

Cat

M2

Cladosporium

E5

Dog

WX1

Weed mix

E5

Dog

M3

Aspergillus

D1

Dustmite

MX1

Mould mix

E6

Guinea pig

M5

Candida albicans

G4

Grass pollen

E82

Rabbit

M6

Alternaria

3

CORE INDIVIDUAL ALLERGENS

CORE INDIVIDUAL ALLERGENS

c Core individual allergens, $4 each

c Core individual allergens, $4 each

Note: Requests for more than five of these will exceed our allowance under Medicare

MITES (HOUSE DUST & STORAGE)

WEED POLLENS

DRUGS

c

F40

Tuna

c

F218

Paprika (sweet pepper)

c

D1

Dermatophagoides pteronyssinus

c

W1

Common ragweed

c

C1

Penicilloyl G

c

F1

Egg white

c

F41

Salmon

c

F220

Cinnamon

c

D2

Dermatophagoides farinae

c

W4

False ragweed

c

C2

Penicilloyl V

c

F2

Milk

c

F44

Strawberry

c

F221

Coffee

c

D70

Acarus siro

c

W5

Wormwood

c

C5

Ampicilloyl

c

F3

Fish (cod)

c

F45

Yeast (S. cerevisiae)

c

F222

Tea

c

D71

Lepidoglyphus destructor

c

W6

Mugwort

c

C6

Amoxicilloyl

c

F47

Garlic

c

F224

Poppy seed

c

D72

Tyrophagus putrescentiae

c

W9

English plantain

c

C7

Cefaclor

c

F48

Onion

c

F225

Pumpkin

c

D73

Glycyphagus domesticus

c

W10

Goosefoot (Lamb’s quarters)

c

C73

Insulin, human

c

F49

Apple

c

F226

Pumpkin seed

c

D74

Euroglyphus maynei

c

W18

Sheep sorrel

c

C74

Gelatin, bovine

c

F59

Octopus

c

F235

Lentil

c

D201

Blomia Tropicalis

c

W21

Parietaria judaica

c

F75

Egg yolk

c

F237

Apricot

c

H2

House dust

c

F79

Gluten

c

F242

Cherry

c

F80

Lobster

c

F244

Cucumber

c

F81

Cheese Cheddar-type

c

F247

Honey

c

F82

Cheese Mould-type

c

F253

Pine nut (pignoles)

TREE POLLENS

c

I1

Honey bee (Apis mellifera)

c

T3

Birch

c

I3

c

T7

Oak

Yellow jacket (Vespula spp.
Common wasp)

c

T8

Elm

c

I4

Paper wasp (Polistes spp.)

c

F83

Chicken meat

c

F255

Plum

c

I5

Yellow hornet (Dolichovespula
arenaria)

c

F84

Kiwi fruit

c

F256

Walnut

c

c

E1

Cat epithelium & dander

T9
T11

Olive
Sycamore, London plane

c

T15

White ash

c

T16

White pine

c

T17

Japanese cedar

c
ANIMAL & AVIAN PROTEINS

c

T18
T19

Eucalyptus
Acacia

c

T21

Melaleuca

c

E3

Horse dander

c

T23

Italian cypress

c

E4

Cow dander

c

T57

Red Cedar

c
c
c

E5
E6
E7

Dog dander
Guinea pig epithelium

FOOD

VENOMS

c

c

T73

Australian pine

c

T210

Privet pollen

Pigeon droppings

c

F4

Wheat

c

F258

Squid

c

F5

Rye

c

F259

Grape

F260

Broccoli

c

F6

Barley

c

c

F7

Oat

c

F261

Asparagus

c

F8

Maize (Corn)

c

F262

Aubergine (eggplant)

c

F9

Rice

c

F263

Green pepper (unripe seed)

c

F10

Sesame seed

c

F267

Cardamon

F270

Ginger

c

F11

Buckwheat

c

c

F12

Pea

c

F279

Chili pepper

c

F13

Peanut

c

F280

Black pepper

c

F281

Curry

Celery

c

F284

Turkey meat

Parsley

c

F287

Red Kidney Bean

F290

Oyster

INSECTS

c

c

I6

Cockroach (Blatella germanica)

MOULDS, YEASTS & TOXINS

c

I70

Fire ant (Solenopsis invicta)

c

M1

Penicillium notatum

c

I71

Mosquito spp. (Aedes communis)

c

M2

Cladosporium herbarum

c

I72

Green nimitti (Cladotanytarsus)

c

M3

Aspergillus fumigatus

c

I202

Grain weevil (Sitophilius granarius)

c

M4

Mucor racemosus

c

M5

Candida albicans (yeast)

PARASITES

c

c

M6

Alternaria alternata

c

P1

Ascaris

c

M8

Helminthosporium halodes

c

P4

Anisakis

c

M9

Fusarium moniliforme

c

M10

Stemphylium botryosum

c

M13

Phoma betae

c

M14

Epicoccum purpurascens

GRASS & GRAIN POLLENS

c

M15

Trichoderma viride

c

G1

Sweet vernal grass

c

M70

Pityrosporum orbiculare

c

G2

Bermuda grass

c

M80

Staphylococcus enterotoxin A

OCCUPATIONALS

c

G4

Grass pollen (Fescue)

c

M202

Cephalosporium acremonium

c

K75

Isocyanate TDI

c

G5

Rye-grass

c

M205

Trichophyton rubrum

c

K76

Isocyanate MDI

c

G6

Timothy grass

c

F26

Pork

c

c

M227

Malassezia spp.

c

K77

Isocyanate HDI

c

G8

Meadow grass

c

F27

Beef

c

K80

Formaldehyde/Formalin

c

G10

Johnson grass

c

F31

Carrot

c

K82

Latex, Hevea braziliensis

c

G11

Brome grass

c

F33

c

K84

Sunflower seed

c

G15

Cultivated wheat

c

c

G17

Paspalum

c
c

c

E71

Mouse epithelium

c

E73

Rat epithelium

c

E77

Budgerigar droppings

c
c
c

E78
E79
E81

Budgerigar feathers
Budgerigar serum proteins
Sheep epithelium

c

E82

Rabbit epithelium

c

E85

Chicken feathers

c
c
c

4

Note: Requests for more than five of these will exceed our allowance under Medicare

E201
E213
E215

Canary bird feathers
Parrot feathers
Pigeon feathers

c

MISCELLANEOUS
c

O1

Cotton crude fibres

c

O70

Seminal fluid

c

F14
F15

Soya bean
White bean

F86

c

F87

Melons

c

c

F88

Mutton

c

F291

Cauliflower

c

F89

Mustard

c

F293

Papaya

c

F90

Malt

c

F294

Passionfruit

Mango fruit

c

F299

Sweet Chestnut

F92

Banana

c

F300

Goat milk

c

F93

Cacao

c

F302

Mandarin

c

F94

Pear

c

F309

Chickpea

c

F95

Peach

c

F315

Green bean

Avocado

c

F317

Coriander

F322

Red currant

c

c

F85

c

F91

F96

c

F17

Hazel nut

c

F201

Pecan nut

c

c

F18

Brazil nut

c

F202

Cashew nut

c

F324

Hop (fruit cone)

c

F20

Almond

c

F203

Pistachio

c

F329

Watermelon

Crab

c

F204

Trout

c

F333

Linseed

Shrimp

c

F207

Clam

c

F335

Lupin

Lemon

c

F338

Scallop

F209

Grapefruit

c

F340

Cochineal (Carmine red, E120)

c

F210

Pineapple

c

F345

Macadamia nut

e

F211

Blackberry

c

F346

Abalone

Orange

c

F212

Mushroom (champignon)

c

F347

Quinoa

F35

Potato

c

F214

Spinach

F36

Coconut

c

F215

Lettuce

F37

Blue mussel

c

F216

Cabbage

c
c
c

F23
F24
F25

Tomato

c

F208

5

CORE ALLERGEN MIXES

ESOTERIC INDIVIDUAL ALLERGENS

c Core mixed allergens $8

e Esoteric individual allergens, $12 each
Note: Requests for more than one of these will exceed our allowance under Medicare.
Some esoteric allergen results may take up to five weeks

Note: Requests for more than two of these will exceed our allowance under Medicare

HOUSE DUST
c

HX2

(H2 D1 D2 I6)

MOULD MIXES
c

Dust & Mite Mix

MX2

(M1 M2 M3
M5 M6 M8)

Mould Mix

ANIMAL MIXES
c

c

c

c

EX1

EX2

EX71

EX72

(E1 E3 E4 E5) Animal Mix 1

(E1 E5 E6
E87 E88)

Animal Mix 2

(E70 E85 E86 Feather Mix
E89)
(E78 E201
E196 E213
E214)

Bird Mix

Cat dander, Horse
dander, Cow dander,
Dog dander
Cat dander, Dog dander,
Guinea pig epithelium,
Rat, Mouse
Goose feathers, Chicken
feathers, Duck feathers,
Turkey feathers
Budgerigar feathers,
Canary bird feathers,
Parakeet feathers, Parrot
feathers, Finch feathers

GRASS MIXES
c

GX2

(G2 G5 G6
G8 G10 G17)

Grass Mix

Bermuda grass, Rye
grass, Timothy grass,
Meadow grass, Johnson
grass, Bahia grass

TREE MIXES
c

TX7

(T9 T12 T16
T18 T19 T21)

Tree Mix

Olive, Willow, White Pine,
Eucalyptus, Acacia,
Melaleuca

Penicillium
chrysogenum,
Cladosporium herbarum,
Aspergillus fumigatus,
Candida albicans,
Alternaria alternata,
Setomelanomma
rostrata

FOOD MIXES
c
c
c

FX1
FX2
FX3

(F13 F17 F18
F20 F36)

Nut Mix

(F3 F24 F37
F40 F41)

Seafood Mix

e

M209

Penicillium frequentans

e

T212

Cedar

e

M208

Chaetomium globosum

e

O202

Artemia salina fish feed

e

T213

Pine

e

M211

Trichophyton ment. var. interdigitale

e

O203

Tetramin fish feed

e

T214

Date

e

M226

Staphylococcus enterotoxin TSST

e

O207

Daphnia fish feed

e

T217

Peppertree

e

M223

Staphylococcus enterotoxin C

e

O211

Mealworm Tenebrio mollitor

e

T218

Virginia live oak

e

M228

Aspergillus flavus

e

O212

Streptavidin

e

T222

Cypress

e

T223

Oil palm

GRASS & GRAIN POLLENS

e

K70

Green coffee bean

e

K71

Castor bean

Fish, Shrimp, Blue
mussel, Tuna, Salmon

e

G7

Common reed

e

W2

Western ragweed

e

K72

Ispaghula

Wheat, Oat, Maize,
Sesame seed,
Buckwheat

e

G9

Redtop (Bentgrass)

e

W3

Giant ragweed

e

K73

Silk waste

e

G12

Cultivated rye

e

W7

Ox-eye daisy

e

K74

Silk

e

G13

Velvet grass

e

W8

Dandelion

e

K78

Ethylene oxide

e

G14

Cultivated oat

e

W11

Saltwort (Russian thistle)

e

K79

Phthalic anhydride

e

G16

Meadow foxtail

e

W12

Golden rod

e

K81

Ficus spp.

e

G70

Wild rye grass

e

W13

Cocklebur

e

K83

Cotton seed

e

G71

Canary grass

e

W14

Common pigweed

e

K85

Chloramin T

e

G201

Barley

e

W15

Scale Lenscale

e

K86

Trimellitic Anhydride (TMA)

e

G202

Maize (Corn)

e

W16

Rough marshelder

e

K87

Alpha-amylase

e

G203

Salt grass

e

W17

Firebush

e

K201

Papain

e

G204

False oat-grass

e

W19

Parietaria officinalis

e

K202

Bromelin

e

W20

Nettle

e

K203

Phosphlipase

e

W22

Japanese Hop

e

K204

Maxatase

e

W23

Yellow dock

e

K205

Alkalase

e

W45

Alfalfa

e

K206

Savinase

e

W46

Dog fennel

e

K208

Lysozyme

e

W82

Careless weed

e

K209

Hexahydrophtalic anhydrid

e

W203

Rape (Canola)

e

K211

MTHP Anhydrid

e

W204

Sunflower

e

K212

Abachi wood dust

e

W206

Camomille

e

K213

Pepsin

e

W207

Lupin

e

K214

Bougainvillea spp.

e

W210

Sugar-beet

Staple Food Mix

Egg white, Milk, Fish,
Wheat, Peanut, Soybean

c

FX15

(F33 F49 F92
F95)

Fruit Mix

Orange, Apple, Banana,
Peach

c

FX19

(F31 F35
F214 F244)

Vegetable Mix

Carrot, Potato, Spinach,
Cucumber

c

FX70

(F272 F274
F273 F275)

Spice Mix 1

Tarragon, Marjoram,
Thyme, Lovage

c

FX71

(F265 RF266
F267 F268)

Spice Mix 2

Caraway, Mace,
Cardamom, Clove

c

FX72

(F269 F219
F270 F271)

Spice Mix 3

Basil, Fennel seed,
Ginger, Anise
Pork, Beef, Chicken

TREE POLLENS
WEED MIXES
c

c

WX1

WX5

(W1 W6 W9
W10 W11)

(W1 W6 W7
W8 W12)

Weed Mix

Weed & Flower
Mix

Common ragweed,
Mugwort, English
Plantain, Goosefoot
Lamb’s Quarters,
Saltwort

OCCUPATIONAL MIXES
c

PAX5

(K75 K76
K77 K79)

Chemicals 1

Isocyanates (TDI, MDI,
HDI), Phthalic anhydride

c

PAX6

(K78 K79
K80 K85)

Chemicals 2

Ethylene oxide,
Phthalic anhydride,
Formaldehyde,
Chloramin T

Common ragweed,
Mugwort, Ox-eye Daisy,
Dandelion, Golden rod

ESOTERIC INDIVIDUAL ALLERGENS
e Esoteric individual allergens, $12 each
Note: Requests for more than one of these will exceed our allowance under Medicare.
Some esoteric allergen results may take up to five weeks
MITES (HOUSE DUST & STORAGE)
e

D3

Dermatophagoides microceras

ANIMAL & AVIAN PROTEINS
e
e

E72

Goose feathers
Mouse urine proteins

E88

Mouse epithelium, serum & urine
proteins

e

E89

Turkey feathers

e

E196

Parakeet feathers

e

E197

Parakeet droppings

e
e

E198
E199

Parakeet serum
Canary bird serum

e

E74

Rat urine proteins

e

E200

Canary bird droppings

e

E75

Rat serum proteins

e

E202

Reindeer epithelium

e

E76

Mouse serum proteins

e
e

E80
E83

Goat epithelium
Swine epithelium

e
e
e

E203
E204
E205

Mink epithelium
BSA (bovine serum albumin)

e
e

E210
E211

Fox epithelium
Rabbit urine proteins

e

E214

Finch feathers

e

E216

Deer epithelium

e

E217

Ferret epithelium

e

E218

Chicken droppings

e

E219

Chicken serum proteins

e

E220

Cat serum albumin

e

E221

Dog serum albumin

e

E222

Swine serum albumin

Horse serum proteins

e

T1

Box-elder

e

T2

Grey alder

e

T4

Hazel

e

T5

American beech

e

T6

Mountain juniper

e

T10

Walnut

e

T12

Willow

e

T14

Cottonwood

e

T20

Mesquite

e

T22

Pecan Hickory

e

T25

European ash

DRUGS

e

T37

Bald cypress

e

C8

Chlorhexidine

e

T41

White hickory

e

C70

e

T44

Hackberry

e

e

T45

Cedar elm

e

e

T54

Russian olive

e

e

T55

Scotch broom

e

T56

Bayberry

e

T57

Red cedar

e

T70

Mulberry

e

T71

Red mulberry

e

T72

Queen Palm

e

T201

Spruce

e

T203

Horse chestnut

e

T205

Elder

e

E84

Hamster epithelium

e

E206

Rabbit serum proteins

PARASITES

e

T206

Chestnut

e

E86

Duck feathers

e

E208

Chinchilla epithelium

e

e

T207

Douglas fir

E87

Rat epithelium, serum & urine
proteins

e

T208

Linden

e

T209

Horn beam

e

6

E70

e

e

E209

Gerbil epithelium

P2

OCCUPATIONALS

WEED & CROP POLLENS

(F1 F2 F3 F4
F13 F14)

(F26 F27 F83) Meat Mix

Sweet gum

Tobacco leaf

Cocksfoot

FX5

FX73

T211

O201

G3

c

c

e

e

e

Peanut, Hazel nut, Brazil
nut, Almond, Coconut

(F4 F7 F8 F10 Cereal Mix
F11)

MISCELLANEOUS

Echinococcus

VENOMS
e

I2

White-faced hornet (Dolichovespula
maculata)

Insulin porcine

e

I77

European paper wasp (Polistes
dominulus)

C71

Insulin bovine

e

I75

European Hornet (Vespa crabro)

C202

Suxamethonium (Succinylcholine)

e

I205

Bumblebee

C208

Tetanus toxoid
INSECTS

MOULDS, YEASTS & TOXINS

e

I8

Moth

e

M7

Botrytis cinerea

e

I73

Blood worm

e

M11

Rhizopus nigricans

e

I76

Berlin beetle

e

M12

Aureobasidium pullulans

e

I201

Horse bot fly

e

M16

Curvularia lunata

e

I203

Mediterranean Flour Moth

e

M36

Aspergillus terreus

e

I204

Horse fly

e

M81

Staphylococcus enterotoxin B

e

I206

Cockroach, American

e

M201

Tilletia tritici

e

I207

Cockroach, Oriental

e

M203

Trichosporon pullulans

e

M204

Ulocladium chartarum

e

M207

Aspergillus niger

7

ESOTERIC INDIVIDUAL FOOD ALLERGENS

ESOTERIC ALLERGEN MIXES

e Esoteric individual food allergens, $12 each

e Esoteric mixed allergens $12 each

Note: Requests for more than one of these will exceed our allowance under Medicare.
Some esoteric allergen results may take up to five weeks
FOOD

Note: Requests for more than one of these will exceed our allowance under Medicare.
Some esoteric allergen results may take up to five weeks
e

e

F272

Tarragon

e

F320

Crayfish

e

F42

Haddock

e

F273

Thyme

e

F321

Horse meat

e

F50

Chub (mackerel)

e

F274

Marjoram

e

F323

Conalbumin

e

F51

Bamboo shoot

e

F275

Lovage

e

F325

Sheep milk

e

F54

Sweet potato

e

F276

Fennel fresh

e

F326

Sheep whey

e

F55

Common millet

e

F277

Dill

e

F328

Fig

e

F56

Foxtail millet

e

F278

Bay leaf

e

F330

Rose hip

e

F57

Japanese millet

e

F283

Oregano

e

F331

Saffron

e

F58

Pacific squid

e

F285

Elk-Moose meat

e

F332

Mint

e

F60

Jack mackerel (Scad)

e

F286

Mare’s Milk

e

F334

Bovine lactoferrin

e

F61

Sardine (Japanese) Pilchard

e

F288

Blueberry

e

F336

Jujube

e

F124

Spelt wheat

e

F289

Date

e

F337

Sole

e

F147

Gulf flounder

e

F292

Guava

e

F339

Allspice

e

F182

Lima bean

e

F295

Carambola

e

F342

Olive (black fresh)

e

F205

Herring

e

F296

Carob (E410)

e

F343

Raspberry

e

F206

Mackerel

e

F297

Gum arabic (E414)

e

F344

Sage

e

F213

Rabbit meat

e

F298

Tragacanth (E413)

e

F348

Lychee

e

F217

Brussel sprouts

e

F301

Persimmon

e

F369

Catfish

e

F219

Fennel seed

e

F303

Halibut

e

F381

Red Snapper

e

F227

Sugar-beet seed

e

F304

Langust (spiny lobster)

e

F384

Whitefish

e

F231

Milk boiled

e

F305

Fenugreek

e

F410

Grouper

e

F234

Vanilla

e

F306

Lime

e

F412

Orange roughy

e

F236

Cow’s whey

e

F307

Hake

e

F413

Pollock

e

F245

Egg

e

F308

Sardine(Pilchard)

e

F414

Tilapia

e

F246

Guar, guar gum (E412)

e

F310

Blue vetch

e

F415

Walleye pike

e

F254

Plaice

e

F311

Megrim

e

F264

Eel

e

F312

Swordfish

e

F265

Caraway

e

F313

Anchovy

e

F266

Mace

e

F314

Snail

e

F268

Clove

e

F316

Rape (Canola) seed

e

F269

Basil

e

F318

Jack fruit

e

F271

Anise

e

F319

Beetroot

RX3

e

ANIMAL MIXES

e

EX70

EX73

(E6 E82 E84
E87 E88)

Animal Mix 3

(E70 E85 E86 Animal Mix 4
E213)

Guinea pig epithelium,
Rabbit epithelium,
Hamster epithelium, Rat,
Mouse

e

8

GX1

GX3

(G3 G4 G5
G6 G8)

(G1 G5 G6
G12 G13)

e

GX4

GX6

Goose feathers, Chicken
feathers, Duck feathers,
Parrot feathers

(G2 G5 G1
W1 W6 W9)

e

RX5

(D1 E1 M3 I6) Inhalant 5

Grass Mix 1

Grass Mix 3

Sweet Vernals grass,
Bermuda grass, Rye
grass, Common
Ragweed, Mugwort,
English Plantain,

(G1 G5 G7
G12 G13)

Grass Mix 4

(G2 G5 G10
G11 G13
G17)

Grass Mix 6

Sweet Vernal grass, Rye
grass, Common reed,
Cultivated rye,Velvet
grass
Bermuda grass, Rye
grass, Johnson grass,
Brome grass, Velvet
grass, Bahia grass

Cocksfoot, Meadow
Fescue, Rye grass,
Timothy grass, Meadow
grass
Sweet Vernal grass, Rye
grass, Timothy grass,
Cultivated Rye, Velvet
grass

e

RX1

(G6 W6 W9
W21 T3)

Inhalant 1

Timothy grass, Mugwort,
English Plantain,
Parietaria, Birch

FX9

(F20 F84 F87
F92 F259)

Food Mix 9

Almond, Kiwi, Melons,
Banana, Grape

e

FX10

(F26 F27 F75
F83 F284)

Food Mix 10

Pork, Beef, Egg yolk,
Chicken, Turkey

e

FX11

(F8 F12 F15
F31 F260)

Food Mix 11

Maize, Pea, White
bean, Carrot, Broccoli

e

FX12

(F5 F9 F35
F225 RF212)

Food Mix 12

Rye, Rice, Potato,
Mushroom, Pumpkin

e

FX13

(F12 F15 F31
F35)

Food Mix 13

Pea, White bean,
Carrot, Potato

e

FX14

(F25 F214 F216 Food Mix 14
F218)

Tomato, Spinach,
Cabbage, Paprika

e

FX16

(F44 F94 F208
F210)

Food Mix 16

Strawberrry, Pear,
Lemon, Pineapple

e

FX17

(F49 F92 F94
F95)

Food Mix 17

Apple, Banana, Pear,
Peach

e

FX18

(F12 F13 F14)

Food Mix 18

Pea, Peanut, Soybean

e

FX20

(F4 F5 F6 F9)

Food Mix 20

Wheat, Rye, Barley,
Rice

e

FX21

(F84 F87 F92
F95 F210)

Food Mix 21

Kiwi fruit, Melon,
Banana, Peach,
Pineapple

e

FX22

(F201 F202
F203 F256)

Food Mix 22

Pecan nut, Cashew
nut, Pistachio, Walnut

e

FX23

(F26 F27 F83
F284)

Food Mix 23

Pork, Beef, Chicken
meat, Turkey meat

e

FX24

(F17 F24 F84
F92)

Food Mix 24

Hazel nut, Shrimp, Kiwi
fruit, Banana

e

FX25

(F10 F45 F47
F85)

Food Mix 25

Sesame seed, Yeast,
Garlic, Celery

e

FX26

(F1 F2 F13 F89) Food Mix 26

Egg white, Cow’s milk,
Peanut, Mustard

e

FX27

(F3 F4 F14 F17) Food Mix 27

Fish (cod), Wheat,
Soybean, Hazel nut

e

FX28

(F10 F24 F27
F84)

Sesame seed, Shrimp,
Beef, Kiwi

e

FX29

(F33 F208 F209 Food Mix 29
F302)

Orange, Lemon,
Grapefruit, Mandarin

e

FX30

(F84 F91 F92
F293)

Food Mix 30

Kiwi, Mango, Banana,
Avocado, Papaya

e

FX31

(F49 F94 F95
F242 F255)

Food Mix 31

Apple, Pear, Peach,
Cherry, Plum

e

FX32

(F235 F12 F15
RF296)

Food Mix 32

Lentil, Pea, White
bean, Carob

e

FX74

(F3 F205 F206
F254)

Food Mix 74

Cod, Herring,
Mackerel, Plaice

TX1

(T1 T3 T7 T8
T10)

Tree Mix 1

Box elder, Birch, Oak,
Elm, Walnut

e

TX2

(T1 T7 T8
T14 T22)

Tree Mix 2

Box elder, Oak, Elm,
Cottonwood, Pecan
Hickory

e

TX3

(T6 T7 T8
T14 T20)

Tree Mix 3

Mountain Juniper, Oak,
Elm, Cottonwood,
Mesquite

e

TX4

(T7 T8 T11
T12 T14)

Tree Mix 4

Oak, Elm, Sycamore,
Willow, Cotttonwood

e

TX5

(T2 T4 T8
T12 T14)

Tree Mix 5

Grey Alder, Hazel, Elm,
Willow, Cottonwood

e

TX6

(T1 T3 T5 T7
T10)

Tree Mix 6

Box elder, Birch,
American Beech, Oak,
Walnut

e

TX8

(T1 T3 T4 T7
T11)

Tree Mix 8

Box elder, Birch, Hazel,
Oak, Sycamore

e

TX9

(T2 T3 T4 T7
T12)

Tree Mix 9

Grey Alder, Birch, Hazel,
Oak, Willow

e

TX10

(T2 T3 T4
T15)

Tree Mix 10

Grey Alder, Birch,White
Ash

e

RX2

(D2 E1 E3 E5
M6)

Inhalant 2

Dermatophagoides
farinae, Cat dander,
Horse dander, Dog
dander, Alternaria
alternata

e

e

WX7

WX209

(W7 W8 W9
W10 W12)

Weed Mix 7

(W1 W2 W3)

Weed Mix 209

FOOD MIXES

e

e

Weed Mix 6

A. fumigatus, A. niger, A.
terreus, A. flavus

Hazel nut, Brazil nut,
Orange, Apple, Cacao

TREE MIXES

(W9 W10
W11 W18)

Mould Mix 4

Food Mix 8

Dermatophagoides
pteronyssinus, Cat
dander, Horse dander,
Dog dander, Rabbit
epithelium

WX6

(M3 M207
M36 M228)

(F17 F18 F33
F49 F93)

Inhalant 7

e

MX4

FX8

(D1 E1 E3 E5
E82)

Weed Mix 3

e

e

RX7

(W6 W9 W10
W12 W20)

Penicillium chrysogenum,
Cladosporium herbarum,
Aspergillus fumigatus,
Alternaria alternata

Tomato, Yeast, Garlic,
Onion, Celery

e

WX3

Mould Mix 1

Food Mix 7

Birch, Timothy grass,
Mugwort, Cladosporium,
Alternaria alternata

e

(M1 M2 M3
M6)

(F25 F45 F47
F48 F85)

Inhalant 6

Weed Mix 2

MX1

FX7

(T3 G6 W6
M2 M6)

(W2 W6 W9
W10 W15)

e

e

RX6

WX2

MOULD MIXES

Dermatophagoides
pteronyssinus, Cat
dander, Aspergillus
fumigatus, Cockroach

e

e

COMBINATION INHALANT MIXES

GRASS MIXES
e

Inhalant 4

RX4

Bermuda grass, Rye
grass, Bahia grass,
Common Ragweed,
English Plantain,
Goosefoot Lamb’s
Quarters

WEED MIXES

Note: Requests for more than one of these will exceed our allowance under Medicare.
Some esoteric allergen results may take up to five weeks

e

Inhalant 3

e

ESOTERIC ALLERGEN MIXES
e Esoteric mixed allergens $12 each

(G2 G5 G17
W1 W9 W10)

Western ragweed,
Mugwort, English
Plantain, Goosefoot
Lamb’s Quarters, Scale
Lenscale
Mugwort, English
Plantain, Goosefoot
Lamb’s Quarters, Golden
rod, Nettle
English Plantain,
Goosefoot Lamb’s
Quarters, Saltwort
Russian Thistle, Sheep
sorrel
Ox-eye Daisy, Dandelion,
English Plantain,
Goosefoot Lamb’s
Quarters, Golden rod
Common ragweed,
Western ragweed, Giant
ragweed

Food Mix 28

OCCUPATIONAL MIXES
e

PAX1

(E3 E4 E70
E85)

Horse & Cow dander,
Goose & Chicken
feathers

e

PAX3

(M3 M6 G12
G15)

Aspergillus, Alternaria,
Wheat & Rye pollen

e

PAX4

(F4 F14 K87
I202)

Wheat & Soy flour,
alpha-amylase,
Sitophilus granarius

9

RECOMBINANT AND NATIVE INDIVIDUAL ALLERGEN MOLECULES

Allergen
Component

n Individual Native (n) $40 each
r

ImmunoCAP ISAC® Allergen Components
Allergen Source
COMMON
NAME

Recombinant (r) allergen molecules $40 each

Protein Group

r

E94

rFel d1 (recombinant cat)

r

E220

nFel d 2 Cat serum albumin Felis
domesticus

r

E101

rCan f1 (recombinant dog)

r

E102

rCan f2 (recombinant dog)

n

E221

nCan f 3 Dog serum albumin
Canis familiaris

n

E204

nBos d 6 BSA, Cow Bos spp.

n

E222

nSus s Pig serum albumin, Swine
Sus scrofa

GRASSES
G205

rPhl p 1 (recombinant timothy)

r

G206

rPhl p 2 (recombinant timothy)

r
r

G208
G209

rPhl p 4 (native timothy)
rPhl p 6 (recombinant timothy)

r

G210

rPhl p 7 (recombinant timothy)

r

G211

rPhl p 11 (recombinant timothy)

r

G212

rPhl p 12 (recombinant timothy)

r

G213

rPhl p1; rPhl p5b (recombinant
timothy)

r
r
n

G214
G215
G216

rPhl p7;rPhl p12 (recombinant
timothy)
rPhl p 5b (recombinant timothy)
nCyn d 1 Bermuda grass,
Cynodon dactylon

COMMON
NAME

F76

nBos d 4 a-lactalbumin, Milk Bos
spp.

c

F77

nBos d 5 b-lactoglobulin, Milk
Bos spp.

c

F78

nBos d 8 Casein, Milk Bos spp.

c Core individual allergens, $4 each
Note: These allergens are priced as core
individual allergens ($4 ea)

Grass group 1

nBos d 6

BSA

Bos domesticus

Serum albumin

rPhl p 1

Timothy

Phleum pratense

Grass group 1

nBos d 8

Cow’s milk

Bos domesticus

Caseins

Grass group 2

nBos d

lactoferrin

Bos domesticus

Laktoferrin

nGal d 1

Egg

Gallus domesticus

Ovomucoid

nGal d 2

Egg

Gallus domesticus

Ovalbumin

r

F351

rPen a 1 Tropomyosin, Shrimp
Penaeus aztecus

r

M218

rAsp f1 (recombinant aspergillus)

rPhl p 2

Timothy

Phleum pratense

r

M219

rAsp f2 (recombinant aspergillus)

nPhl p 4

Timothy

Phleum pratense

r

M220

rAsp f 3 (recombinant aspergillus)

rPhl p 5

Timothy

Phleum pratense

rAsp f4 (recombinant aspergillus)

rPhl p 6

Timothy

Phleum pratense

nGal d 3

Egg

Gallus domesticus

Conalbumin

rAsp f6 (recombinant aspergillus)

rPhl p 11

Timothy

Phleum pratense

nGal d 5

CSA (Livetin)

Gallus domesticus

Serum albumin

rBet v 1

Birch

Betula verrucosa

PR-10 protein

rCyp c 1

Carp

Cyprinus carpio

Parvalbumin

rAln g 1

Alder

Alnus glutinosa

PR-10 protein

rGad c 1

Cod

Gadus callarias

Parvalbumin

Corylus avellana

PR-10 protein

rDer f 1

r

F353

rGly m 4 PR-10, Soy Glycine

r

F354

rBer e 1 Brazil nut, Bertholletia
excelsa

r

F355

rCyp c 1 Carp Cyprinus carpio

r
r

M221
M222

r

F417

rApi g 1.01 PR-10, Celery Apium
graveolens

r

r

F418

rApi g 1.02 (recombinant Celery)

LATEX

r

F419

rPru p 1 PR-10, Peach Prunus
persica

r

M229

K215

rAlt a 1 (component alternaria)

rCor a 1.0101 Hazel pollen

rHev b 1, Latex Hevea brasiliensis

Platanus acerifolia

rEur m 2

Storage mite

Euroglyphus maynei

Ambrosia artemisiifolia

rCan f 1

Dog

Canis familiaris

Lipocalin

nArt v 1

Mugwort

Artemisia vulgaris

rCan f 2

Dog

Canis familiaris

Lipocalin

nArt v 3

Mugwort

Artemisia vulgaris

Lipid transfer protein (nsLTP)

nCan f 3

Dog

Canis familiaris

Serum albumin

rPar j 2

Wall pellitory

Parietaria Judaica

Lipid transfer protein (nsLTP)

nEqu c 3

Horse

Equus caballus

Serum albumin

nSal k 1

Saltwort

Salsola kali

rFel d 1

Cat

Felis domesticus

Uteroglobin

nAct d 1

Kiwi

Actinidia deliciosa

nFel d 2

Cat

Felis domesticus

Serum albumin

nAct d 2

Kiwi

Actinidia deliciosa

nMus m 1

Mouse

Mus musculus

Lipocalin

nAct d 5

Kiwi

Actinidia deliciosa

rAlt a 1

Alternaria

Alternaria alternata

nAct d 8

Kiwi

Actinidia deliciosa

PR-10 protein

rAlt a 6

Alternaria

Alternaria alternata

rApi g 1

Celery

Apium graveolens

PR-10 protein

rAsp f 1

Aspergillus

Aspergillus fumigatus

rDau c 1

Carrot

Daucus carota

PR-10 protein

rAsp f 2

Aspergillus

Aspergillus fumigatus

rMal d 1

Apple

Malus domestica

PR-10 protein

rAsp f 3

Aspergillus

Aspergillus fumigatus

rPru p 1

Peach

Prunus persica

PR-10 protein

rAsp f 4

Aspergillus

Aspergillus fumigatus

nPru p 3

Peach

Prunus persica

Lipid transfer protein (nsLTP)

rAsp f 6

Aspergillus

Aspergillus fumigatus

rAna o 2

Cashew nut

Anacardium occidentale

rCla h 8

Cladosporium

nAra h 1

Peanut

Arachis hypogaea

Storage protein, vicilin

Cladosporium
herbarum

nAra h 2

Peanut

Arachis hypogaea

Storage protein, Conglutin

nAra h 3

Peanut

Arachis hypogaea

Storage protein, 11S globulin

rAra h 1 Peanut Arachis hypogaea

r

K221

rHev b 8, Profilin, Latex Hevea
brasiliensis

r

r

K222

rHev b 9, Latex Hevea brasiliensis

K224

rHev b 11, Latex Hevea
brasiliensis

r

F352

rAra h 8 PR-10, Peanut Arachis
hypogaea

r

r

F427

rAra h 9 LTP, Peanut Arachis
hypogaea

VENOM

r

F425

rCor a 8 LTP, Hazel nut Corylus
avellana

n

K203

nApi m 1, Phospholipase A2, Bee
Apis mellifera

r

F426

rGad c 1 Cod Gadus morhua

OCCUPATIONAL ALLERGENS

r

F428

rCor a 1 PR-10, Hazel nut Corylus
avellana

n

K205

Alkalase, Bacillus spp.

n

K87

nAsp o 1, a-amylase Aspergillus
oryzae

TREES

r
r
r

rBet v 1 PR-10, Birch Betula
verrucosa

n

K201

nCar p 1, Papain, Papaya Carica
papaya

rBet v 2 Profilin, Birch Betula
verrucosa

n

K208

nGal d 4, Lysozyme, Egg Gallus
spp.

n

K204

Maxatase, Bacillus licheniformis

rAra h 8

Peanut

Arachis hypogaea

n

K206

Savinase, Bacillus spp.

rBer e 1

Brazil nut

Bertholletia excelsa

n

K213

nSus s Pepsin, Swine Sus scrofa

rCor a 1.0401 Hazelnut

Corylus avellana

rCor a 8

Hazelnut

OTHERS (to exclude CCD reactivity)

nCor a 9

n

Ro214

MUXF3 CCD, Bromelin

n

K202

nAna c 2 Bromelin, Pineapple
Ananas comosus

T220

rBet v 4, Birch Betula verrucosa

T221

rBet v 2, rBet v 4 Birch Betula
verrucosa

T225
T224

F232

nGal d 2 Ovalbumin, Egg Gallus
spp.

WEEDS

n

F233

nGal d 1 Ovomucoid, Egg Gallus
spp.

r

F323

nGal d 3 Conalbumin, Egg Gallus
spp.

n

W211

nDer p 2

Ragweed

F422

T216

Platanus acerifolia

Plane tree

r

r

Plane tree

nAmb a 1

K220

T215

rPla a 1
nPla a 2

r

r

Olea europaea

K219

F416

rAra h 3 Peanut Arachis hypogaea

Olive

rBet v 6 Birch Betula verrucosa
nOle e 1 Olive Olea europaea

rPar j 2 (recombinant parietaria)

dust

rHev b 6.01, Latex Hevea
brasiliensis

r

F424

nOle e 1

rDer f 2

rHev b 5, Latex Hevea brasiliensis

rHev b 6.02, Latex Hevea
brasiliensis

r

Cupressus arizonica

K218

rTri a 19 Omega-5 Gliadin, Wheat
Triticum spp
rAra h 2 Peanut Arachis hypogaea

Cypress

Dermatophagoides
farinae
Dermatophagoides
farinae
Dermatophagoides
pteronyssinus
Dermatophagoides
pteronyssinus

r

F421

F423

Japanese ceder Cryptomeria japonica

nCup a 1

dust

rHev b 3, Latex Hevea brasiliensis

rPru p 4 Profilin, Peach Prunus
persica

r

nCry j 1

House
mite
House
mite
House
mite
House
mite

K217

rPru p 3 LTP, Peach Prunus
persica

r

Grass group 5

r

F420

n

nDer p 1

nApi m 1
nApi m 4

dust
dust

Honey bee
venom
Honey bee
venom

Apis mellifera

Phospholipase A2

Apis mellifera

Melittin

PR-10 protein

rBla g 1

Cockroach

Blattella germanica

Storage protein, 2S albumin

rBla g 2

Cockroach

Blattella germanica

PR-10 protein

rBla g 4

Cockroach

Blattella germanica

Corylus avellana

Lipid transfer protein (nsLTP)

rBla g 5

Cockroach

Blattella germanica

Hazelnut

Corylus avellana

Storage protein, 11S globulin

rAni s 1

Anisakis

Anisakis simplex

rGly m 4

Soybean

Glycine max

PR-10 protein

nGly m 5

Soybean

Glycine max

Storage protein, b-conglycinin

nGly m 6

Soybean

Glycine max

Storage protein, glycinin

Sesame seed

Sesamum indicum

Storage protein, 2S albumin

nTri a 18

CROSS REACTIVE MARKERS, NON-PLANTS
rAni s 3

Anisakis

Anisakis simplex

Tropomyosin

nBla g 7

Cockroach

Blattella germanica

Tropomyosin

Dermatophagoides
pteronyssinus

Tropomyosin

W230

nAmb a 1, Ragweed Ambrosia
elatior

nSes i 1

Wheat

Triticum aestivum

rDer p 10

W231

nArt v 1, Mugwort Artemisia
vulgaris

House dust
mite

nTri a gliadin Wheat

Triticum aestivum

Crude gliadin

rPen a 1

Shrimp

Penaeus aztecus

Tropomyosin

rTri a 19.0101 Wheat

Triticum aestivum

Omega-5 gliadin

nPen i 1

Shrimp

Penaeus indicus

Tropomyosin

nTri a aA_TI

Wheat

Triticum aestivum

nPen m 1

Shrimp

Penaeus monodon

Tropomyosin

rHev b 1

Latex

Hevea brasiliensis

rHev b 3

Latex

Hevea brasiliensis

rHev b 5

Latex

Hevea brasiliensis

rHev b 6

Latex

Hevea brasiliensis

ImmunoCAP ISAC® ($350 per profile)
The ISAC (Immuno Solid-phase Allergen Chip) is a microarray system developed by VBC Genomics and Phadia. ISAC can now allow laboratories
to reliably and simultaneously determine specific IgE levels to a wide range of clinically important individual allergen molecules more economically
than using many individual recombinant CAP allergens.
Clinical studies have shown that, for example, even modest levels of serum specific IgE level to ara h 2, one of the nine major peanut allergens,
are strongly predictive of more severe reactions and poor tolerance of oral challenges. Similarly, modest levels of serum specific IgE to ovomucoid,
an egg allergen which is heat resistant, are strongly predictive of poor tolerance to even cooked egg in a baked cake; the first challenge usually
used by allergy clinics when one is confident that a child might be starting to lose their egg allergy.
The ISAC profiles are performed in batches, and the results are reported semi-quantitatively and organised into both the individual allergen
molecule source, as well as the protein group from which it comes. These protein groups have particular patterns of clinical significance. For
example, specific IgE to Lipid Transfer Proteins are often associated with systemic and more severe reactions in addition to oral allergy symptoms
and these molecules are usually not altered with food preparation and cooking (enzyme digestion and heat). Similarly, seed storage proteins
are also heat resistant and often associated with significant symptoms with cooked foods. In contrast, PR-10 proteins are heat labile and are
associated with oral allergy symptoms with the raw, rather than cooked foods. Similarly, heat sensitive profilin proteins are more associated
with nuisance rather than severe symptoms. Tropomyosin proteins account for dustmite-crustacean cross-reactivity. Animal albumins and fish
parvalbumins are important causes of other food reactions.
A table of the allergens included in the ISAC profile is shown opposite.

10

Bermuda grass Cynodon dactylon

MOULDS

n

n

NON-PLANTS

nCyn d 1

nBos d Lactoferrin, Milk Bos spp.

n

FOODS

Protein Group
LATIN NAME

F334

FOODS
c

Allergen Source

n

r

r

Allergen
Component

LATIN NAME

PLANTS

ANIMALS

ImmunoCAP ISAC® Allergen Components

CROSS REACTIVE MARKERS, PLANTS
Calcium binding protein,
Polcalcin
Calcium binding protein,
Polcalcin

rBet v 4

Birch

Betula verrucosa

rPhl p 7

Timothy

Phleum pratense

rBet v 2

Birch

Betula verrucosa

Profilin

rHev b 8

Latex

Hevea brasiliensis

Profilin

rMer a 1

Annual mercury Mercurialis annua

Profilin

nOle e 2

Olive

Olea europaea

Profilin

rPhl p 12

Timothy

Phleum pratense

Profilin

nAna c 2

Bromelain

Ananas comosus

CCD marker

11

BILLING POLICY FOR ALLERGY TESTING
Our policy is to respect your request for the allergens and decode them according to our best practice. If you have requested
more allergens than our allowance under Medicare, we will bill your patient according to the pricing in this menu. If you have
nominated the patient to be bulk-billed or if the patient has signed a Medicare assignment form, this billing policy will still apply
for all tests above our allowance under Medicare.
You will see in our Allergy menu that we now list a price for each allergen reagent and that this is organised into different allergen
classes. Core individual allergens are $4, core mixed allergens are $8, esoteric individual allergens are $12 and esoteric mixed
allergens are also $12. Our highly specialised recombinant (r) or native (n) individual allergen molecules are $40, and the ISAC
profile, which tests 103 different individual allergen molecules from 47 different allergens, is $350.
If the price of the allergens requested is more than the Medicare rebate of $22.95, the laboratory will not accept bulk-billing
for the request and the patient will be billed according to the price on the menu and may claim a rebate, subject to coning.
Practically, this means we will not accept a bulk-billed request for more than five core individual allergens, or two core mixed
allergens, or more than one esoteric individual or mixed allergens. However, one core mixed allergen plus three core individual
allergens would be covered by the Medicare rebate. Similarly, two core mixed allergens plus one core individual allergen would
be covered under our allowance under Medicare. One esoteric mixed or individual allergen plus two core individual allergens or
one core mixed allergen would be covered under our allowance under Medicare. A simple table summarises this for you and
your patients.

Please note that eligible patients may be able to claim a rebate on four occasions per year for testing
performed on separately collected blood, with each episode at least 14 days apart.

WHAT CAN YOU ORDER THAT IS MEDICARE REBATABLE?
Our Fee For Different Allergen Types
Core individual

$4

Core mix		

$8

Esoteric Individual

$12

Esoteric Mix 		

$12

Recombinant/ Native

$40

Medicare Rebatable

Private Bill

Combinations beyond the black line will be privately billed but patients may be eligible for a Medicare rebate of $22.95.

DOUGLASS HANLY MOIR PATHOLOGY • ABN 80 003 332 858
A subsidiary of SONIC HEALTHCARE

14 GIFFNOCK AVENUE • MACQUARIE PARK • NSW 2113 • AUSTRALIA
TEL (02) 98 555 222 • (02) FAX 9878 5077
MAIL ADDRESS • LOCKED BAG 145 • NORTH RYDE • NSW 1670 • AUSTRALIA

BARRATT & SMITH PATHOLOGY • ABN 80 003 332 858
A trading name of DOUGLASS HANLY MOIR PATHOLOGY
A subsidiary of SONIC HEALTHCARE

31 LAWSON STREET • PENRITH • NSW 2750 • AUSTRALIA
TEL (02) 4734 6500 • FAX (02) 4732 2503
MAIL ADDRESS • PO BOX 443 • PENRITH • NSW 2751 • AUSTRALIA

Printed on re-cycled paper

DHMP/B&S-AV2-2010-Brochure

For further information regarding allergy testing please contact Dr Karl Baumgart,
Director of Immunology on (02) 98 555 286 or email kbaumgart@dhm.com.au



---

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