Leica ISH User Manual To The 7a52d343 Fd5e 431a 9fc4 541efd96bf3f

User Manual: Leica ISH to the manual

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Leica BOND RX
– Fully Automated IHC & ISH
Quality. Speed. Flexibility.

Research Use Only. Not for use in diagnostic procedures.

Quality

Clarity that enhances insight

Speed

More slides, more opportunities

Flexibility
The freedom of open research

Total Freedom

Total Assistance

Total Research

Choose the ideal reagents

Receive unrivalled support

Create a total research solution

There are no limits to the reagents

Call Leica Biosystems’ IHC and

Because researchers need specialized

you can use on the truly open

ISH research experts for help with

instruments and consumables,

Leica BOND RX . Freely select

instrument setup, applications

Leica Biosystems supports you with

Novocastra BOND reagents

knowledge and responsive service.

research-specific histology and

or any other antibody, probe

•• Training and protocol development

microscopy systems including:

or detection component.

•• Applications advice

•• Cryostats and microtomes

•• Novocastra BOND reagents

•• Flexible maintenance contracts

•• Microscopes

•• Novocastra manual reagents

•• Scanning and imaging solutions

Leica BOND RX

With over 12 million people diagnosed
with cancer every year*, new insights
that lead to better treatments will
significantly improve many lives.
The answers are there to be
discovered if the barriers to innovation
are removed.
You need the flexibility to explore new
possibilities, clear results to ensure
nothing is missed and rapid,
cost‑effective systems that let you
perform more tests.
Clear the path to discovery and
life‑changing breakthroughs become
closer than ever before.

Leica BOND RX is part of a complete research
solution that gives you the freedom to discover.

Research Use Only. Not for use in diagnostic procedures.

* GLOBOCAN 2008
Cancer Incidence and Mortality Worldwide in 2008

Clarity and Accuracy

Complete Consistency

Total Tissue Care

Choose Novocastra BOND reagents to

No matter what reagents you choose,

Protect valuable tissue. The unique

make it easier to deliver high-quality

the fully automated Leica BOND RX

Leica BOND Covertile™ system

staining. Specifically developed for

will standardize your staining to

provides the utmost care for valuable

Leica BOND using Leica’s in‑house

remove process variation and

specimens. Unlike other automated

Novocastra staining science,

deliver unrelenting consistency.

stainers, Leica BOND has very gentle

these pre‑optimized reagents

Leica BOND RX provides full onboard

reagent application and incubation

deliver exceptional performance

IHC and ISH automation with both

protection that minimizes the potential

with minimal preparation.

Leica and laboratory protocols.

for tissue damage and costly repeats.

Leica BOND RX

QUALITY
Make sure you see the whole picture. Leica BOND RX consistently provides the high‑quality
results that let you clearly analyze every stain so vital information is not overlooked, and
every section gets you one step closer to new insights.

Research Use Only. Not for use in diagnostic procedures.

Faster

Continuous

Ready for More

Finish slides earlier. Leica BOND RX

Your work flows when you are

As your research program grows, so

is 50% faster than previous

both flexible and organized. With

does Leica BOND. With the ability

generation stainers. So you can

three independent slide trays, each

to connect up to five Leica BOND RX

process more slides in a day,

Leica BOND RX is effectively three

instruments to a single data collection

gain a rapid understanding of the

stainers in one instrument. So you

point, you are free to expand capacity

possibilities of your latest trials, and

have the flexibility of continuous

so your research never slows down.

reach critical answers sooner.

processing while keeping your
slides together to reduce sorting.

Leica BOND RX

SPEED
Find answers sooner. With speed and organization, Leica BOND RX lets you stain more
slides daily. This gives you the freedom to explore more possibilities, test more theories,
and make that critical breakthrough sooner.

Research Use Only. Not for use in diagnostic procedures.

Truly Open

Fully Flexible

Cost Effective

Always use the antibodies, probes

You are free to explore with the

Control costs and do more

and detection components that best

easy‑to‑use Leica BOND RX software.

research with your existing budget.

suit your research. Leica BOND RX

You can use Leica protocols for

Leica BOND RX requires virtually

is a truly open system so you are

pre‑defined consistency, or freely

no daily maintenance and has

free to choose the reagents that

create your own custom protocols

extremely small reagent dispense

provide the most accurate results in

when your research calls for

volumes so you can spend less time

in the most cost-effective manner.

something special. New insights

and money on overheads, and more

require innovative thinking and with

on making critical discoveries.

Leica BOND RX you’re not locked
into conventional methods.

Leica BOND RX

Flexibility
Eliminate barriers to discovery. Important research should never be held up by mandated
reagents. So Leica BOND RX has truly open reagents and allows protocol customization.
With Leica BOND RX dispensing your reagents in the sequence you choose, you are free
to uncover scientific breakthroughs faster, and more cost-efficiently.

Research Use Only. Not for use in diagnostic procedures.

System Specifications
Dimensions

775 mm (W) x 1359 mm (H) x 785 mm (D)
30.5 in (W) x 53.5 in (H) x 30.9 in (D)

Weight (dry)

246 kg
542 lb.

Slide capacity

30 slides
Finished trays (10 slides) may be replaced
continuously

Reagent container capacity

7 mL and 30 mL

Number of reagent containers

36 reagents

Bulk reagent container capacity

2 L or 5 L

Hazardous waste container capacity

5L

Standard waste container capacity

2x5L

Operating voltage

100 to 240 V~

Mains frequency

50/60 Hz

Power consumption

1200 VA

Maximum operating temperature

35 °C (95 °F)

Minimum operating temperature

5 °C (41 °F)

Temperature required to meet
staining performance requirements

18–26 °C (64–79 °F)

Operating humidity (noncondensing)

10 to 80% RH

Operating altitude

0 to 1600 m (5250 ft.) above sea level

Sound pressure level output (at 1 m)

< 85 dBA maximum
< 65 dBA normal operation

Flexibility

Quality

1. Open Reagents

2. Custom Protocols

3. Covertile Technology

4. Continuous Processing

Leica BOND RX open containers
make loading and running your
reagents easy and cost-effective.
This truly open system lets you
choose antibodies, probes and
detection components from any
source.

Control dispense sequences,
incubation times and temperature
settings with the Leica BOND RX
protocol editor. This flexibility,
along with open reagents, gives
you complete freedom over your
IHC and ISH staining.

Unlike other systems,
Leica BOND RX is gentle on the
tissue and ensures total tissue
care with exceptionally low
dispense and waste volumes.

Leica BOND RX is effectively
three independent stainers in one
instrument - the ideal balance
of flexibility and organization.

Leica BOND RX

2
5

4

1
3

Speed

5. Parallel Automation
Inside Leica BOND RX there
are four very active robots
simultaneously moving, dispensing
and ensuring high throughput and
rapid turnaround.

Research Use Only. Not for use in diagnostic procedures.

www.LeicaBiosystems.com

Total Histology Solutions
High-quality IHC and ISH staining depends upon expert tissue preparation
and sectioning. With a broad range of histology instruments, consumables
and applications knowledge, Leica Biosystems offers research‑specific
histology solutions that will help you efficiently prepare high‑quality
sections for advanced staining.
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LEICA biosystems
Leica Biosystems is a global leader in workflow solutions bringing
histopathology laboratories and researchers the highest quality, most
comprehensive product range in anatomical pathology. With complete
histology systems featuring innovative automation, NovocastraTM
reagents and Surgipath® consumables, Leica Biosystems offers the ideal
product for each histology step and high-productivity workflow solutions
for the entire laboratory.

Tissue preparation
Sample identification and tracking
Tissue processors, cassettes and paraffin wax
Embedding centers, accessories and paraffin wax
Microtomes, blades and slides
Coverslippers, mountants and coverslips
Microscopy and imaging solutions
Expert service and support
Ongoing maintenance support

Leica Biosystems brings
together products, quality and
support. Offering a complete
solution that helps you advance
workflows, enhance diagnostic clarity and
deliver what really matters – better patient care.

Leica Biosystems – an international company with a strong network of
worldwide customer services:
North America Sales and Customer Support
North America

800 248 0123

Asia/Pacific Sales and Customer Support

Use your smart phone to find out
more about Leica BOND RX .

Australia

1800 625 286

Download the free mobile app at

China

+85 2 2564 6699

http://gettag.mobi, then scan this tag.

Japan

+81 3 5421 2804

South Korea

+82 2 514 65 43

New Zealand

0800 400 589

Singapore

+65 6779 7823

Europe Sales and Customer Support
For detailed contact information about European sales offices or distributors please
visit our website.

95.10599 Rev B - Order no. 1195.10599 ∙ 09/2012 ∙ Copyright © by Leica Biosystems
Melbourne Pty Ltd, Melbourne, Australia, 2012. Subject to modifications. LEICA and the
Leica Logo are registered trademarks of Leica Microsystems IR GmbH.



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