IL 17_Infographic_R13_SF Copy 17A Infographic

2015-05-08

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ABOUT INTERLEUKIN 17-A (IL-17A)
A MESSENGER PROTEIN (OR CYTOKINE) FOUND TO PLAY A KEY ROLE IN PSORIASIS AND OTHER AUTOIMMUNE DISEASES

1-4

HOW INCREASED LEVELS OF IL-17A AFFECT THE SKIN IN PSORIASIS

5-7

Too many skin cells cause:

IL-17A signals to skin
cells (keratinocytes),
which grow in number

8-11

THICKENED SKIN

IL-17A signals to
infection-fighting cells to
go to infection site

Too much IL-17A

IL-17A IS UP TO
6X HIGHER IN
PSORIASIS THAN
IN NORMAL SKIN
Higher IL-17A levels may
cause more severe
psoriasis symptoms

PLAQUES

Infection-fighting cells
cause inflammation:
FEW SYMPTOMS

ITCHING

REDNESS

MANY SYMPTOMS

IL-17A: A POTENTIAL
NEW TARGET
2,5,12-16

FEEDBACK LOOP CREATED
Infection-fighting
cells create
more and more
IL-17A

DANGER

IL-17A wrongly
continues to signal
that more skin cells
and infection-fighting
cells are needed

Researchers are investigating targeted therapies that
inhibit IL-17A and may prevent the “feedback
loop” that can cause psoriasis and other
autoimmune diseases.
Research also shows directly targeting IL-17A does
not appear to compromise the immune system,
which can happen with some psoriasis treatments.

HOW IL-17A CAN AFFECT OTHER PARTS OF THE BODY
JOINTS

Psoriatic arthritis

SPINE

Ankylosing spondylitis

References
1. Miossec P, Kolls JK. Nat Rev Drug Discov. 2012 Oct;11(10):763-76. doi: 10.1038/nrd3794. 2. Ivanov S & Linden A. Trends in Pharmacological Sciences. 2009; 30(2):95-103. 3. McKenzie BS, et al. Trends in immunology. 2006; 27(1):17-23. 4. Hu Y, et al. Annals of the New York Academy of Sciences. 2011
Jan;1217:60-76. 5. Chiricozzi A, Guttman-Yassky E, Suárez-Fariñas M, et al. J Invest Dermatol. 2011;131:677-687. 6. Martin DA, Towne JE, Kricorian G, et al. J Invest Dermatol. 2013 Jan;133(1):17-26. 7. Nestle FO, et al. N Engl J Med. 2009; 361(5):496-509. 8. Johansen C, et al. Brit J Dermatol. 2009; 160:319-24. 9.
Arican O, et al. Mediators Inflamm. 2005; Oct 24;2005(5):273-9. 10. Mayo Clinic website (Psoriasis symptoms). Accessed 15 August 2013. 11. Kopf M, et al. Nat Rev Drug Discov. 2010; 9(9):703-18. 12. Onishi RM & Gaffen SL. Immunology. 2010; 129(3):311-21. 13. Krueger J et al. J Allergy Clin Immunol.2012;
130(1):145-154. 14. Patel DD, Lee DM, Kolbinger F, et al. Ann Rheum Dis. 2012 Dec 9 [Epub ahead of print]. 15. Puel A, Cypowyj S, Bustamante J, et al. Science. 2011;332:65-68. 16. Puel A, Döffinger R, Natividad A. J Exp Med. 2010;207:291-297.

4

LUNGS
Asthma

ILPR002/0714
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