IL 17_Infographic_R13_SF Copy 17A Infographic
2015-05-08
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References
1. Miossec P, Kolls JK. Nat Rev Drug Discov. 2012 Oct;11(10):763-76. doi: 10.1038/nrd3794. 2. Ivanov S & Linden A. Trends in Pharmacological Sciences. 2009; 30(2):95-103. 3. McKenzie BS, et al. Trends in immunology. 2006; 27(1):17-23. 4. Hu Y, et al. Annals of the New York Academy of Sciences. 2011
Jan;1217:60-76. 5. Chiricozzi A, Guttman-Yassky E, Suárez-Fariñas M, et al. J Invest Dermatol. 2011;131:677-687. 6. Martin DA, Towne JE, Kricorian G, et al. J Invest Dermatol. 2013 Jan;133(1):17-26. 7. Nestle FO, et al. N Engl J Med. 2009; 361(5):496-509. 8. Johansen C, et al. Brit J Dermatol. 2009; 160:319-24. 9.
Arican O, et al. Mediators Inflamm. 2005; Oct 24;2005(5):273-9. 10. Mayo Clinic website (Psoriasis symptoms). Accessed 15 August 2013. 11. Kopf M, et al. Nat Rev Drug Discov. 2010; 9(9):703-18. 12. Onishi RM & Gaffen SL. Immunology. 2010; 129(3):311-21. 13. Krueger J et al. J Allergy Clin Immunol.2012;
130(1):145-154. 14. Patel DD, Lee DM, Kolbinger F, et al. Ann Rheum Dis. 2012 Dec 9 [Epub ahead of print]. 15. Puel A, Cypowyj S, Bustamante J, et al. Science. 2011;332:65-68. 16. Puel A, Döffinger R, Natividad A. J Exp Med. 2010;207:291-297.
HOW INCREASED LEVELS OF IL-17A AFFECT THE SKIN IN PSORIASIS5-7
Researchers are investigating targeted therapies that
inhibit IL-17A and may prevent the “feedback
loop” that can cause psoriasis and other
autoimmune diseases.
Research also shows directly targeting IL-17A does
not appear to compromise the immune system,
which can happen with some psoriasis treatments.
THICKENED SKIN PLAQUES
ITCHING REDNESS
JOINTS
Psoriatic arthritis SPINE
Ankylosing spondylitis
LUNGS
Asthma
HOW IL-17A CAN AFFECT OTHER PARTS OF THE BODY4
Higher IL-17A levels may
cause more severe
psoriasis symptoms
Too many skin cells cause:
Infection-fighting cells
cause inflammation:
IL-17A signals to skin
cells (keratinocytes),
which grow in number
IL-17A signals to
infection-fighting cells to
go to infection site FEW SYMPTOMS MANY SYMPTOMS
FEEDBACK LOOP CREATED
Infection-fighting
cells create
more and more
IL-17A
IL-17A wrongly
continues to signal
that more skin cells
and infection-fighting
cells are needed
DANGER
Too much IL-17A
IL-17A IS UP TO
6X HIGHER IN
PSORIASIS THAN
IN NORMAL SKIN8-11
ABOUT INTERLEUKIN 17-A (IL-17A)
A MESSENGER PROTEIN (OR CYTOKINE) FOUND TO PLAY A KEY ROLE IN PSORIASIS AND OTHER AUTOIMMUNE DISEASES1-4
IL-17A: A POTENTIAL
NEW TARGET2,5,12-16
ILPR002/0714
