Neuwave Brochure Spreads V15 PL 000223 Rev A System Product

2016-01-06

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PROVEN SYSTEM DEVELOPED BY PHYSICIANS
The NeuWave Medical® Intelligent Ablation System was developed by physicians and microwave scientists at the University of
Wisconsin who were looking for a better solution for patients with soft tissue lesions.

Versatile probe portfolio for tailored
treatments with 1, 2 or 3 probes
Synchronized energy delivery for
consistent multi-probe ablations
CO2 cooling for the smallest
gauge probe and Tissu-Loc™
to reduce probe migration
Ablation Confirmation™ to
show you if you got it all!

SUPPORTED BY TRAINING AND EDUCATION
Dedicated Clinical Specialists for case coverage

Regional case observation and hands-on learning labs

Comprehensive physician and staff training with a
formal competency evaluation and certification

Peer-to-peer collaboration for case review with key
thought-leaders

NeuWave Medical didactic and in-vivo animal
training labs

Reimbursement hotline: 800-400-7651

POSITIONED FOR THE FUTURE
NeuWave Medical is focused on meaningful clinical innovation and product differentiation to drive better patient outcomes and
lower costs. Our computer-controlled platform, developed with an open architecture enables all systems to be easily upgraded
with additional features and enhancements.

For more information on the NeuWave Medical® Intelligent Ablation System, contact us:

877-323-WAVE (9283)
info@NeuWave.com
NeuWave.com

DISCLAIMER: The Certus 140 2.45 GHz Ablation System is a tool, not a treatment for any disease or condition. It is cleared for the ablation (coagulation) of soft tissue in percutaneous, open surgical
and in conjunction with laparoscopic surgical settings in patients who present themselves to a treating physician with a wide variety of diseases or conditions. The Certus 140 2.45 GHz Ablation
System is not indicated for use in cardiac procedures. The system is designed for facility use and should only be used under the orders of a physician.

(c) NeuWave Medical 2015
PL-000233 REV A 8/15

MICROWAVE LEADS ABLATION MARKET GROWTH
The U.S. ablation market is growing rapidly due to the rising interest in minimally invasive options. Microwave ablation is
currently the fastest growing modality in the ablation market, and will largely replace radiofrequency as the preferred ablation
choice in the future.1

MICROWAVE ABLATION
TO SURGE IN THE U.S.
The growth of microwave ablation
continues to surge in the U.S. due to the
limitations imposed by the alternative RF
ablation technology.1

“The use of microwave ablation will increase
substantially in the liver and lung indications
through 2023...Some companies, such as
NeuWave Medical, provide devices that are
specifically designed to effectively ablate
tissue in delicate, aerated lung tissue.”
- Millennium Research Group 2015 1

HOW MICROWAVE
ABLATION WORKS
Microwave ablation is a minimally invasive outpatient
procedure that uses electromagnetic waves to generate soft
tissue necrosis in the lung, liver and kidney.

1
2

3

Using CT or Ultrasound imaging, a small probe is
inserted percutaneously into lesion.
Electromagnetic waves are delivered to the tissue,
producing frictional heating to generate tissue
necrosis at >60°C.
Ablation Confirmation™ software, only from
Neuwave Medical®, is used to assess the technical
success of the ablation procedure.

BENEFITS OF
MICROWAVE ABLATION*
Supported by multiple Clinical Practice Guidelines.
Strong efficacy and low complication rate versus
other common treatment modalities.1
Most procedures completed with 5-10 minutes of
ablation time.
Many patients leave the hospital the same day2 as
the procedure with only a bandage at the probe
insertion point.

“From a patient’s perspective, this procedure is really wonderful because it’s very
precise and the aftermath impacts are negligible. I didn’t have any discomfort, I
was up the next day feeling fine and I was back in the classroom the day after.”
- Kevin McSweeny, patient**

ABLATION PROCEDURE GROWTH 2013 - 2023
35000

Radiofrequency Ablation
30000

-4.1%

Cryoablation

5.9%

Microwave Ablation

14.8%

25000

20000

15000

Precision™ PR
probe inserted
into lesion

10000

500

0
CAGR 2013 - 2023

1. Interventional Oncology Devices / US/ 2015 Market Analysis Millennium Research Group, August 2014

* All medical procedures carry potential risks that should be discussed with patients prior to any microwave ablation procedure. See the Certus 140 User Manual for a full list of warnings and cautions.
1. T. Ziemlewicz, et al, Percutaneous Microwave Ablation of Hepatocellular Carcinoma with Gas-Cooled System: Initial Clinical Results with 107 Tumors. Journal of Vascular Interventional Radiology 2015;
26: 62–68. A. Moreland, et al, High-Powered Microwave Ablation of T1a Renal Cell Carcinoma: Safety and Initial Clinical Evaluation. Journal Of Endourology Sept. 2014; Volume 28, Number 9. B.T.
March, et al, Microwave ablation for lung neoplasms: a retrospective analysis of long term results. Journal of Vascular and Interventional Radiology 2014, Volume 25, Issue 3 , S97.
2. J. Horn, et al, Percutaneous Microwave Ablation of Renal Tumors Using a Gas-Cooled 2.4-GHz Probe: Technique and Initial Results. Journal of Vascular Interventional Radiology 2014; 25: 448 – 453

THE NEUWAVE MEDICAL® INTELLIGENT ABLATION SYSTEM
When it comes to ablating lesions, achieving the best outcomes for each individual patient is paramount. The totality of the
NeuWave Medical Intelligent Ablation System allows you to tailor treatments to each patients’ clinical need and offers the only
integrated in-procedure confirmation of your ablation.

COMPUTER CONTROLLED SYSTEM DELIVERING HIGH
POWERED, FAST ABLATIONS

VERSATILE PROBE PORTFOLIO WITH MULTI-PROBE SYNCHRONY
FOR TAILORED TREATMENTS WITH 1, 2 OR 3 PROBES
PRECISION™ PR PROBE

MAX™ LK AND LN PROBES

For ≤ 4 cm, single probe tissue sparing ablations1

Tissue-tuned for large, single probe ablations2

4

Touchscreen interface

≤ 4 cm single probe ablations in any soft tissue1

7,6

MAX LK single probe ablations2
≤ 7 cm = liver, ≤ 6 cm = kidney

The only probe available with limited ablation
length to limit necrosis of adjacent tissue,
including critical structures

6

MAX LN single probe ablation2
≤ 6 cm = lung

Procedure data stored and
easily accessible
Daily call home system for
performance monitoring

10 min burn

10 min burn

5 min burn

5 min burn

2 min burn

2 min burn
1 cm emitting point

2 cm emitting point

Independent power and time control
on each channel during procedure
PR PROBE BURN PATTERN: Tip-weighted probe with emitting point 1 cm
from tip. Ablation encompasses tip and then burns proximally (away).

Highest power output = faster
ablation (195W)

LK & LN PROBE BURN PATTERNS: Ablation progresses uniformly both
distally and proximally from the emitting point 2 cm from tip.

MULTI-PROBE SYNCHRONY
Multiple synchronized probes create larger and more
spherical ablation zones than a single repositioned probe3
Rounder ablations with no clefting

Increased confidence in covering target with
less reliance on precise probe placement
Consistent, predictable ablations as waves
work in synchrony

CO2 COOLED SYSTEM FOR THE SMALLEST GAUGE PROBE
AND TISSU-LOC™ TO REDUCE PROBE MIGRATION
17 gauge probe =
Less invasive procedures

Reduces probe migration
Tissu-Loc™ technology “sticks" the
probe in place, minimizing probe
migration during imaging and
additional probe placement

NeuWave Medical®
17g
Competition
13g
NEUWAVE MEDICAL®: 3 synchronized probes

COMPETITION: 1 probe repositioned 3 times

1. Bovine liver ex-vivo: 65W, 5 minutes = 4.14 cm x 2.64 cm, 65W, 10 minutes = 4.65 cm x 3.06 cm, Bovine kidney ex-vivo: 65W, 5 minutes = 3.28 cm x 2.30 cm, 65W, 10 minutes = 3.82 cm x 2.60 cm,
Bovine lung ex-vivo: 65W, 5 minutes = 2.80 cm x 1.74 cm, 65W, 10 minutes = 4.08 cm x 3.22 cm
2. Bovine liver ex-vivo: 140W , 5 minutes = 6.0 cm x 3.7cm, 140W , 10 minutes = 7.0 cm x 4.0 cm, Bovine kidney ex-vivo: 140W , 5 minutes = 4.4 cm x 2.5 cm, 140W , 10 minutes = 6.4 cm x 3.4 cm, Bovine
lung ex-vivo: 140W , 5 minutes = 6.0 cm x 3.3 cm, 140W , 10 minutes = 6.0 cm x 3.9 cm
3. Laeseke et al. Multiple-Antenna Microwave Ablation: Spatially Distributing Power Improves Thermal Profiles and Reduces Invasiveness. Journal of Interventional Oncology. 2009; 2(2):105-112. Brace et
al. Simultaneous Activation of Multiple Microwave Antennas Improves Circularity and Ablation Zone Volume Compared to Sequentially Overlapping Ablations. Presented at conference with
accompanying poster, WCIO 2014.

ABLATION CONFIRMATION™ OFFERING THE ONLY INTEGRATED
IN-PROCEDURE CONFIRMATION TO SHOW YOU IF YOU GOT IT ALL!
Ablation Confirmation (AC) is a CT image processing software that resides on a second, dedicated monitor attached to the NeuWave
Medical Intelligent Ablation System. AC takes the uncertainty out of procedures by assisting physicians in identifying ablation probe
placement and confirming ablation zones without having to leave the procedure room.

ABLATION CONFIRMATION™ IN 3 EASY STEPS
1

DEFINE YOUR TARGET

2D View

Pull set-up CT scan into
software
Segment lesion

BENEFITS OF ABLATION CONFIRMATION
Confident Probe Placement
See the exact proximity of the probe to the
lesion so you can ablate with greater confidence

Define margin
Confirm Complete Ablation
Verify technical success of the procedure
by viewing combined target and ablation
zone scans
Segmented lesion and margin defined

Collaborate with Colleagues Remotely
Remote access allows colleagues to support
ablation cases in real-time

WITH
ABLATION CONFIRMATION

Demonstrate Your Success
Clear 2D and 3D procedure images are
stored to PACS and can be shared among
patients, referrers and peers to showcase
your procedure success

2

PLACE PROBES AND VERIFY

Periscope and Needle View

Place probes, perform
CT scan and pull scan
into software
Register scans to assess
probe placement in
relationship to
identified target

WITHOUT
ABLATION CONFIRMATION

Available Views:
2D, 3D, Periscope
and Needle
Probe missed lesion

3

ABLATE AND CONFIRM

Probe placed in lesion

3D View

Perform ablation, take
post-procedure CT scan
and pull scan into software
Segment ablation zone
Target

Ablation Zone

Pre-procedure and post-procedure scans registered
(overlaid) into one image to confirm technical success
of procedure.

Pre-Procedure Scan

Post-Procedure Scan

Pre-procedure and post-procedure scans are on separate
monitors. Physician must "imagine" scans overlaid in attempt
to confirm technical success of procedure.

Register ablation scans
to assess and/or confirm
technical success of
procedure
Available Views:
2D, 3D
Ablation doesn’t cover lesion and margin

Ablation covers lesion and margin



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Swatch Colorant Type            : PROCESS, PROCESS, PROCESS, PROCESS, PROCESS, PROCESS, PROCESS, PROCESS, PROCESS, PROCESS, PROCESS, PROCESS, PROCESS, PROCESS, PROCESS, PROCESS, PROCESS, PROCESS, PROCESS, PROCESS, PROCESS, PROCESS, PROCESS, PROCESS, PROCESS, PROCESS, PROCESS, PROCESS, PROCESS, PROCESS, PROCESS, PROCESS, PROCESS, PROCESS, PROCESS, PROCESS, PROCESS, PROCESS, PROCESS, PROCESS, PROCESS, PROCESS, PROCESS, PROCESS, PROCESS, PROCESS, PROCESS, PROCESS, PROCESS, PROCESS, PROCESS, PROCESS, PROCESS, PROCESS, PROCESS, PROCESS, PROCESS, PROCESS
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Swatch Colorant Magenta         : 0.000000, 0.000000, 100.000000, 0.000000, 0.000000, 0.000000, 100.000000, 100.000000, 100.000000, 90.000000, 80.000000, 50.000000, 35.000000, 0.000000, 0.000000, 0.000000, 0.000000, 10.000000, 30.000000, 0.000000, 10.000000, 15.000000, 50.000000, 95.000000, 100.000000, 100.000000, 100.000000, 100.000000, 100.000000, 95.000000, 25.000000, 45.000000, 50.000000, 60.000000, 40.000000, 50.000000, 60.000000, 65.000000, 70.000000, 70.000000, 25.781250, 0.000000, 0.000000, 0.000000, 0.000000, 0.000000, 0.000000, 0.000000, 0.000000, 0.000000, 0.000000, 0.000000, 100.000000, 75.000000, 10.000000, 10.000000, 90.000000, 90.000000
Swatch Colorant Yellow          : 0.000000, 0.000000, 100.000000, 100.000000, 100.000000, 0.000000, 0.000000, 0.000000, 90.000000, 85.000000, 95.000000, 100.000000, 85.000000, 90.000000, 100.000000, 100.000000, 100.000000, 100.000000, 95.000000, 75.000000, 45.000000, 0.000000, 0.000000, 5.000000, 25.000000, 0.000000, 0.000000, 35.000000, 50.000000, 20.000000, 40.000000, 50.000000, 60.000000, 65.000000, 65.000000, 75.000000, 80.000000, 90.000000, 100.000000, 80.000000, 58.203125, 0.000000, 0.000000, 0.000000, 0.000000, 0.000000, 0.000000, 0.000000, 0.000000, 0.000000, 0.000000, 0.000000, 100.000000, 100.000000, 95.000000, 100.000000, 0.000000, 0.003100
Swatch Colorant Black           : 0.000000, 100.000000, 0.000000, 0.000000, 0.000000, 0.000000, 0.000000, 0.000000, 10.000000, 0.000000, 0.000000, 0.000000, 0.000000, 0.000000, 0.000000, 0.000000, 0.000000, 10.000000, 30.000000, 0.000000, 0.000000, 0.000000, 0.000000, 0.000000, 25.000000, 0.000000, 0.000000, 10.000000, 0.000000, 0.000000, 0.000000, 5.000000, 25.000000, 40.000000, 0.000000, 10.000000, 25.000000, 35.000000, 50.000000, 70.000000, 2.343750, 100.000000, 89.999400, 79.998800, 69.999700, 59.999100, 50.000000, 39.999400, 29.998800, 19.999700, 9.999100, 4.998800, 0.000000, 0.000000, 0.000000, 0.000000, 0.000000, 0.003100
Producer                        : Adobe PDF library 15.00
Page Count                      : 4
EXIF Metadata provided by EXIF.tools

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