Release Notes Chromeleon 7.2.6 7.2.6m User Manual
2017-10-25
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Release Notes
Chromeleon 7
Chromatography Data System
Software Version 7.2.6 • August 2017
Chromeleon 7
Copyright
For Research Use Only. Not for use in diagnostic procedures. Copyright © 2009‐2017 Thermo Fisher Scientific
Inc. All rights reserved.
Trademarks
ACQUITY, Alliance and Waters are registered trademarks of Waters Corporation. ACQUITY, Alliance and Waters
are registered trademarks of Waters Corporation. Agilent is a registered trademark of Agilent Technologies.
Microsoft, Windows 8.1 Pro, .NET Framework and SQL Server are registered trademarks of Microsoft
Corporation. PerkinElmer and Clarus are registered trademarks of PerkinElmer Inc. Shimadzu is a trademark of
Shimadzu Corporation. Air Server‐xr, TD100‐xr UNITY‐xr and Kori‐xr are trademarks of Markes International Ltd.
WibuKey is owned by Wibu Systems.
All other trademarks are property of Thermo Fisher Scientific Inc. and its subsidiaries.
Thermo Fisher Scientific Inc. provides this document to its customers with a product purchase to use in the
product operation. The document is copyright protected; any reproduction of the whole or any part of this
document is strictly prohibited, except with the written authorization of Thermo Fisher Scientific Inc.
This document is provided “as is”. The contents of this document are subject to being changed, without notice,
in future revisions.
Thermo Fisher Scientific Inc. makes no representations that this document is complete, accurate, or error‐free.
Thermo Fisher Scientific Inc. assumes no responsibility and will not be liable for any errors, omissions, damage,
or loss that might result from any use of this document, even if the information in the document is followed
properly.
This document is not part of any sales contract between Thermo Fisher Scientific Inc. and a purchaser. This
document shall in no way govern or modify any Terms and Conditions of Sale. The Terms and Conditions of Sale
shall govern all conflicting information between the two documents.
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Chromeleon 7
Table of Contents
1 Introduction ............................................................................................................................. 5
2 Other Documentation ............................................................................................................. 6
3 What’s New in Chromeleon 7.2.6 ........................................................................................... 7
3.1 New and Updated Thermo Scientific Instrument Drivers ................................................ 7
3.1.1 New ISQ EC Mass Spectrometer Driver [SWFR‐1214] ............................................... 7
3.1.2 Updated Vanquish Horizon Binary Pump (VH‐A10) Driver [SWFR‐2700] ................... 7
3.1.3 Updated TRACE 1110 FPD [SWFR‐2474] .................................................................... 7
3.1.4 Updated TRACE 1300 GC Driver [SWFR‐1518, SWFR‐1512, SWFR‐1558].................. 7
3.1.5 Fraction Collection Wizard Support For Multiple Channels [SWFR‐1192]................. 7
3.2 New and Updated Third Party Instrument Drivers ........................................................... 7
3.2.1 New Markes Thermal Desorber Driver [SWFR‐1234] ................................................ 8
3.3 IQ/OQ/PQ .......................................................................................................................... 8
3.3.1 Linking an IQ Template to Multiple Sequences [SWFR‐2567] ................................... 8
3.3.2 HPLC IQ for new ISC EC LC/IC MS [SWFR‐2649] .......................................................... 8
3.4 Chromeleon XPS................................................................................................................ 8
3.4.1 Chromeleon XPS Optional User Interface [SWFR‐2207] ............................................ 8
3.4.2 Chromeleon XPS User Privileges [SWFR‐2430] ........................................................... 9
3.5 Email Notification Enhancements..................................................................................... 9
3.5.1 Send E‐Mail on Sequence Completion or Abort [SWFR‐2281] .................................. 9
3.5.2 Notification of License Grace Period [SWFR‐2841, SWFR‐1090] ................................ 9
3.5.3 Notification of Pending Expiration for Temporary Licenses [SWFR‐2899] ................. 10
3.6 Processing Method Enhancements .................................................................................. 10
3.6.1 Identify Peaks Based on Mass Spectrum [SWFR‐967] ............................................... 10
3.6.2 Support for Target Mass Screening [SWFR‐1483] ...................................................... 10
3.6.3 BioPharma Workbook Import with Exactive Acquisition List [SWFR‐2093] .............. 10
3.6.4 Perform ISTD quantitation Based on Ratio (Resp) vs Ratio (Amt) [SWFR‐2374] ....... 10
3.7 Other Chromatography Studio Enhancements ................................................................ 10
3.7.1 Labeling a Chromatogram Peak with the Detected Mass [SWFR‐1482].................... 10
3.7.2 Fixed Axis Scaling For MS Components Plot [SWFR‐2655] ......................................... 10
3.7.3 Relative Standard Error as a Report Variable [SWFR‐2467]....................................... 10
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4 Resolved Issues ........................................................................................................................ 11
5 Limitations and Known Issues ................................................................................................. 15
5.1 Limitations with Thermo Scientific Instruments............................................................... 15
5.2 Compatibility of Chromeleon 7.2.6 and SII for Xcalibur ................................................... 16
5.3 Mass Spectrometers and Windows 10 ............................................................................. 17
5.4 Upgrading a Windows 10 PC From Chromeleon 7.2 SR5 to Chromeleon 7.2.6 ............... 17
5.5 Compatibility with Foundation 3.1 ................................................................................... 17
5.6 Limitations with the Waters Driver Pack .......................................................................... 17
5.7 Limitations with Agilent ICF .............................................................................................. 19
5.8 Limitations with Other Third Party Instruments............................................................... 21
5.9 Other Limitations .............................................................................................................. 22
5.10 Obsolete Drivers ............................................................................................................... 24
5.11 Defects Under Investigation ............................................................................................. 24
5.11.1 Empty Inject Time and GUID Fields in the Injection Record [CM7‐22738] ............ 25
5.11.2 Instrument Audit Trails Are not Properly Saved/Written on the local Data Vault
[CM7‐23051] ......................................................................................................................... 25
5.12 Functional Differences between Chromeleon 7.2 and Chromeleon 6.8 .......................... 25
6 Backward/Forward Compatibility Issues ................................................................................. 26
6.1 Thermo Scientific Vanquish Charged Aerosol Detector [CM6‐23499] ............................. 26
6.2 Thermo Scientific Vanquish Autosampler [CM6‐23405] .................................................. 26
6.3 Thermo Scientific TriPlus RSH ........................................................................................... 26
6.4 Thermo Scientific TriPlus 300 HS ...................................................................................... 26
6.5 Thermo Scientific TriPlus LS‐100 ....................................................................................... 26
6.6 Thermo Scientific TSQ Quantiva ....................................................................................... 26
6.7 Thermo Scientific TSQ Quantiva and Endura .................................................................... 26
6.8 TSQ Quantiva and Endura Instrument Method [CM7‐18759].......................................... 26
6.9 Signed Sequences [CM7‐16374] ....................................................................................... 27
7 Appendix .................................................................................................................................. 28
7.1 Release Notes ................................................................................................................... 28
7.2 Online Help ....................................................................................................................... 28
7.3 Contributed Content ......................................................................................................... 28
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Chromeleon 7
1 Introduction
The Thermo Scientific™ Chromeleon™ 7 Chromatography Data System (CDS) is a new‐generation
chromatography data system that provides the fastest path from samples to results. Building upon
market‐leading innovations of prior Chromeleon software releases – such as dynamic interactive data
displays, an integrated database for rapid data retrieval, and spreadsheet‐based reporting –
Chromeleon 7 features a modern user interface, comprehensive new tools for peak detection, and an
innovative workflow management framework, all of which speed up learning, simplify operation, and
deliver results with greater efficiency than any other chromatography data system.
This new version, Chromeleon 7.2 .6 CDS, provides updated and new instrument control for
instruments from Thermo Fisher Scientific and other vendors. Improvements and enhancements
have been made in a number of areas related to data processing and visualization. In addition, this
release introduces Chromeleon XPS ‐ a highly streamlined and simplified optional user interface for
Chromeleon to support walkup automation lab environments. Please see below for more details on
these and other enhancements present in this release.
The software is developed using modern software development tools and technologies that improve
performance, sustainability and extendibility.
Backward compatibility with Chromeleon 6 is maintained to the greatest practicable extent, to
provide an easy migration path.
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Chromeleon 7
2 Other Documentation
Chromeleon is provided with many other documents that will help you to learn more about the
software. Their scope is described in the Document Overview, which is delivered in printed form with
the Chromeleon installation media, but also available in electronic form on the installation disk in the
Documents folder.
Please refer to the Installation Guide for information regarding:
System Requirements
Supported Operating Systems and Databases
Required Third‐Party Software
Compatibility with Previous Versions
Installing and configuring the Chromeleon software
Tip: The Glossary describes Chromeleon‐specific terms and common abbreviations used
throughout the documentation.
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3 What’s New in Chromeleon 7.2.6
Chromeleon 7.2.6 implements a number of new features, including support for new hardware,
Chromeleon XPS (a new simplified user interface for open access walkup automation labs) and
improvements to data review and processing of MS data. This document will only give a short
overview of all features without going into much detail. For more details, refer to the Online Help.
3.1 New and Updated Thermo Scientific Instrument Drivers
This chapter lists new and updated Thermo Scientific™ drivers added to Chromeleon 7.2.6. For
details on supported options, required licenses, installation, and control, refer to the Online Help or
the List of Supported Instruments document found on the Chromeleon 7.2.6 DVD.
3.1.1 New ISQ EC Mass Spectrometer Driver [SWFR‐1214]
This release includes support for the new Thermo Scientific ISQ EC, which is a single quadrupole mass
spectrometer for HPC and IC.
3.1.2 Updated Vanquish Horizon Binary Pump (VH‐A10) Driver [SWFR‐2700]
The Vanquish Horizon Binary Pump driver and ePanel have been enhanced to include the ability to
perform a pump leak test.
3.1.3 Updated TRACE 1110 FPD [SWFR‐2474]
The TRACE 1110 GC driver has been enhanced to support an updated Flame Photometric Detector
with a higher temperature range.
3.1.4 Updated TRACE 1300 GC Driver [SWFR‐1518, SWFR‐1512, SWFR‐1558]
The TRACE 1300 GC driver has been enhanced as follows:
An option has been added to the configuration dialog to allow the GC hardware keyboard to
remain unlocked while still connected to Chromeleon.
An option has been added to the method editor to restore default values for all of the
method settings on a page or for an entire method.
It is now possible to start detector acquisition at a time other than 0.0 min.
3.1.5 Fraction Collection Wizard Support For Multiple Channels [SWFR‐1192]
The existing fraction collection wizard has been enhanced to include the setup of multiple channels
and all fraction collection parameters.
3.2 New and Updated Third Party Instrument Drivers
This chapter lists new and updated drivers added to Chromeleon 7.2.6. For details on supported
options, required licenses, installation, and control, refer to the Online Help and the List of Supported
Instruments document found on the Chromeleon 7.2.6 DVD.
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3.2.1 New Markes Thermal Desorber Driver [SWFR‐1234]
This release includes a new instrument driver to control the following modules from the Markes
Thermal Desorber product line:
TD‐100‐xr Standard (including the Tube IS accessory)
TD‐100‐xr Advanced (including the Tube IS accessory)
Unity‐xr (including the Air Server accessory)
Kori‐xr
3.3 IQ/OQ/PQ
3.3.1 Linking an IQ Template to Multiple Sequences [SWFR‐2567]
It is now possible to create and store a single instance of the qualification report templates in a
folder outside of a sequence and link multiple qualification sequences to that template.
3.3.2 HPLC IQ for new ISC EC LC/IC MS [SWFR‐2649]
The HPLC IQ templates have been updated to support for the new Vanquish ISQ EC MS module.
3.4 Chromeleon XPS
3.4.1 Chromeleon XPS Optional User Interface [SWFR‐2207]
Chromeleon XPS is a highly simplified user interface for Chromeleon that provides walk‐up, multi‐
user access for routine analysis by non‐chromatographers.
Features include:
Clean, streamlined “walk‐up” interface
Utilizes the full power of Chromeleon’s user management, instrument control, data
processing and reporting
Provides access to all instruments in an Enterprise environment
Supports IC, LC, GC, LCMS, GCMS and ICMS analysis
eMail notification of run completion and analysis results
Management console with advanced customization options
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Important: Chromeleon XPS is a licensed option for Chromeleon, Please contact your local
Thermo Fisher Scientific representative for details on enabling this functionality.
3.4.2 Chromeleon XPS User Privileges [SWFR‐2430]
The User Management permissions set have been enhanced to control the ability to use and manage
the Chromeleon XPS software.
The new permissions include:
Manage User Interface
Allows a lab manager to customize the Chromeleon XPS user interface, specify available
eWorkflows and define default behaviors
Use Client User Interface
Required in order for a user to be able to log into Chromeleon XPS
3.5 Email Notification Enhancements
3.5.1 Send E‐Mail on Sequence Completion or Abort [SWFR‐2281]
With this release, it is now possible to have an e‐mail notification sent to one or more users when a
sequence completes or is aborted. The e‐mail includes basic information such as sequence name,
instrument, and time/date as well as a link to the sequence itself.
3.5.2 Notification of License Grace Period [SWFR‐2841, SWFR‐1090]
With this release, when the software license dongle is inaccessible (e.g. due to a network problem) a
notification is displayed in the message bar of the Chromeleon Console.
In addition, it is possible to enable an email notification be sent to alert appropriate people.
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3.5.3 Notification of Pending Expiration for Temporary Licenses [SWFR‐2899]
With this release, it is possible to enable an email notification when a temporary software license is
about to expire.
3.6 Processing Method Enhancements
3.6.1 Identify Peaks Based on Mass Spectrum [SWFR‐967]
It is now possible to specify an MS spectrum and match criteria in the processing method which can
be used to identify or confirm the identification of components.
3.6.2 Support for Target Mass Screening [SWFR‐1483]
With this release, it is now possible to specify target screening masses on a per‐injection basis. The
specification also includes support for positive and negative adducts. Mass spectrum plots may be
tagged with the target mass (if detected) and report variables can be used to display and test if the
target mass was detected.
3.6.3 BioPharma Workbook Import with Exactive Acquisition List [SWFR‐2093]
The Compound Import feature of the processing method has been enhanced to support Biopharma
Finder workbook export files.
3.6.4 Perform ISTD quantitation Based on Ratio (Resp) vs Ratio (Amt) [SWFR‐
2374]
With this release, when using variable internal standard amounts the default calibration option for
new sequences is now to compute the response factor based on Response Ratio vs. Amount Ratio.
3.7 Other Chromatography Studio Enhancements
3.7.1 Labeling a Chromatogram Peak with the Detected Mass [SWFR‐1482]
When performing targeted mass screening, it is now possible to label a chromatographic peak with
the detected mass.
3.7.2 Fixed Axis Scaling For MS Components Plot [SWFR‐2655]
The MS Components report object has been enhanced to allow specification of a fixed signal scale.
This response range may be directly supplied by the user or may be automatically extracted from a
reference injection.
3.7.3 Relative Standard Error as a Report Variable [SWFR‐2467]
Relative Standard Error (%RSE) is now being required in a number of EPA standard methods. This
release includes %RSE as a standard report variable.
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Chromeleon 7
4 Resolved Issues
This chapter describes the issues that have been resolved with the release of Chromeleon 7.2.6.
Many trivial and minor issues have been resolved, but are not mentioned here. If you require
information about the status of an issue observed in a Chromeleon 7 release, but which is not listed
here, please contact your local Thermo Fisher Scientific representative for more information.
The numbers in the first column of the table below refer to the Thermo Fisher Scientific tracking IDs.
ID
Description
CM7‐23867
A2D: Occasionally when an A2D was unplugged from an IPC, the Audit Trail would
contain repeated "{A2D} Data out of sequence" errors until the A2D was
reconnected. The Audit Trail now shows two new messages: "{A2D} A2D USB
communication error" and "{A2D} Driver has disconnected", each of which is
reported just once.
AS/AI 1310 Sampler: Occasionally, a new sampler from the factory was unable to
connect to Chromeleon.
Calibration: Injections used for fixed calibration with MS were not written to the
chromatogram cache so that results had to be recalculated whenever accessed
causing poor performance.
Calibration: Response level tolerances were always computed using the amounts
specified in the processing method, without taking into account normalization for
sample weight, dilution factor, inject volume and amount ratios.
Calibration: When calculating confidence limits, applied injection weight or dilution
factor corrections were not taken into account meaning that
peak.confLowerLimit("computed") was equivalent to
peak.confLowerLimit(peak.amount). The same applied also for the upper limits.
Chromatogram Plot: If a Chromeleon 6 sequence displaying Retention Time and
Component Name as Peak Labels on the Chromatogram plot was opened in
Chromeleon 7 the Peak Labels would not be shown correctly.
Console: In rare cases, the data category navigation tree icons would not display
properly.
Copy/Paste: When the MS Components plot was smart linked, expanding a single plot
then copy‐and‐pasting the plot resulted in pasting of the smart linked plot rather than
the expanded plot.
Electronic Report: The report variables 'gen.reportTime' and 'gen.reportOperator' did
not display current value when used in a report variable in the grid, since they were
not updated in report tables and plots after each action. The report variables are now
properly updated.
Electronic Signatures: When signing a sequence that was currently in the process of
being uploaded to the Enterprise Data Vault, the data audit trail did not contain
entries recording the electronic signature event. A warning is now displayed and the
user is no longer permitted to sign sequences that are being uploaded.
eWorkflows: Adding additional samples to a Sequence that was created from an
eWorkflow would always place the new samples after the Footer block. Chromeleon
now provides an option to "preserve" the [Header][Sample][Footer] layout when
additional samples are added by re‐running the eWorkflow.
eWorkflows: In the eWorkflows editor, an option has been added to specify if the
bracket block should also be included before the footer block
eWorkflows: When using an eWorkflow to append injections to a sequence that was
created by a different eWorkflow, if the sequence contained injection custom
variables, an error stating "Different field definition for an existing injection custom
variable" was generated.
CM7‐23552
CM7‐22328
CM7‐23893
CM7‐23925
CM7‐8269
CM7‐23995
CM7‐23771
CM7‐23852
CM7‐23833
CM7‐23419
CM7‐6793
CM7‐23401
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Chromeleon 7
ID
Description
CM7‐23950
eWorkflows: XVault sequence was not used when appending injections using
eWorkflows, to a running sequence.
Extracted Ion Chromatograms: In some instances, the start or end times of a
component extracted ion chromatogram for a specific injection would vary
depending on which other injection in the sequence was selected.
Extracted Ion Chromatograms: When extracting an ion chromatogram from MS data,
the data extracted was correct, but the channel name indicated an incorrect
extraction window by default.
GCMS Environmental Extension Pack: The Ad Hoc BFB Tune Report incorrectly
evaluated m/z 173 criterion.
Help and Manuals: Shimadzu LC‐20A and LC‐30A ‐ The online help did not describe
fully the necessary steps for using Inject Synchronisation.
Import/Export: Export of sequence data to Microsoft Excel occasionally caused
Chromeleon to generate various errors due to exceeding GDI limits.
Import/Export: If a Sequence imported from Chromeleon 6 contained a large number
of history entries, attempts to copy the Sequence, or Send to CMBX could result in an
"Exception of type 'System.OutOfMemoryException' was thrown" error message.
Import/Export: Occasionally, after importing a Chromeleon 6.8 CMB file, Chromeleon
would report an error "Chromeleon is no longer working and needs to be closed.
CM7‐23250
CM7‐24036
CM7‐23895
CM7‐23963
CM7‐23732
CM7‐24083
CM7‐24021
CM7‐21418
CM7‐23600
CM7‐24055
CM7‐23567
CM7‐23723
CM7‐23883
CM7‐23364
CM7‐23769
CM7‐23843
CM7‐23740
CM7‐23009
CM7‐23230
CM7‐23724
Import/Export: Producing PDF and Excel exports simultaneously resulted in incorrect
page numbering in the exported files.
Installation: When upgrading an Instrument PC from Chromeleon 7.2 SR4 to 7.2 SR5,
if there were sequences still in the instrument queue that had not been uploaded to
the remote server, an ˜Upload Failure" error would be displayed and reported in the
DataError.log and TxpStatistic.log log files.
Interactive Results: When displaying Interactive Results in the Studio for unknowns, if
calibration‐related settings (e.g. dilution factor) are changed in the console for a
calibration standard, the Interactive Results table was not automatically refreshed to
display the updated amounts.
Non‐Targeted MS Data Processing: Modifying only the table filter parameters did not
trigger a save option.
Non‐Targeted MS Data Processing: The Relative Reference Injection number setting
now starts at 1 instead of 0.
OQ/PQ: If the Station PQ was run more than once within the same client session, the
following actions were skipped after the first run: "Ready Check for Queue", "Check
Instrument Status", "Check Instrument State", "Start Queue", "Stop Queue", and
"Edit Sequence in Queue."
OQ/PQ: If an action was set to be not executed during the PQ, any actions depending
on this would also not be executed during the PQ.
Printing: When performing an ad hoc print of the processing method, the settings for
the Concentration Level Tolerances were not included in the printout.
Processing Method: Under certain circumstances, it was not possible to display the
processing method (or open a sequence with the processing method displayed). This
occurred when the number of frozen columns = number of columns and the size of
the Studio window was too small to show all columns of the table.
Query: When searching for injections by date using the operator "Is Not During
Previous", the query result would also return injections created/modified during the
current day.
Report Designer: When closing print preview, GDI objects for plot objects were not
released, resulting in a memory leak.
Report Variables: An incorrect value was reported when extracting the 2nd and
higher “By Intensity” masses from a library spectrum.
Report Variables: In some instances, the Non‐Targeted MS Data Processing Result
Status variable would not update in real‐time, resulting in incorrect in‐spec / not‐in‐
spec results being displayed in the report template.
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ID
Description
CM7‐23616
Report Variables: The peptide category report variables displayed "n.a." when used in
a summary table.
Report Variables: When specifying a custom percent height for the calculation of
peak width, only integer values were accepted. This has been updated to support
decimal values.
Report Variables: When using different injection volumes in a calibration curve, the
amount deviation report variable was calculated incorrectly.
Sequence: Appending a new injection to an existing sequence or inserting a new
injection in an existing sequence caused an error message stating 'The privilege "Copy
Injection" is missing.' These operations now require only the privilege "Add New
Injection".
Sequence: If a value was entered in a table column that had a greater number of
decimal places than the precision specified for the column, an error that there were
too many digits was displayed. The entered value is now accepted but rounded to
match the column's precision.
Sequence: If the ESC key was pressed very quickly after stating the New Sequence
Wizard, it was possible for a Null Reference Exception error to occur.
Sequence: Importing a Chromeleon 6.8 report into Chromeleon 7 that contains a
large number of images (plots, etc.), then attempting to submit the sequence in
Chromeleon 7 would cause the software to crash.
Sequence: It was possible to make and save changes to the associated items and
some other fields in an unconverted imported sequence.
Sequence: Use of default export template defined per sequence when running a
multi‐sequence queue resulted in only the use of the default template for the first
sequence for the entire queue.
Sequence: Use of default report template defined per sequence when running a
multi‐sequence queue resulted in only the use of the default template for the first
sequence for the entire queue.
System Status Report: If the SSR encountered a file which had the Read‐only flag set,
it would fail with an error "Deleting temporary files: Unable to remove the temporary
files: Access to path denied".
System Status Report: If the SSR failed to delete a temporary file, it was not included
in the report.
System Status Report: If the SSR was not able to access the Instrument Audit Trails,
the Instrument Audit Trails section of the Summary Report would report this, but
with an unclear message.
TRACE 1110 GC: Although the instrument front panel supported values from 0 to 100
ml/min for the inlet flow rate, the maximum value allowed by the instrument method
editor was 70 for a Packed inlet with EPC, and 25 for a PTV inlet with EPC.
TRACE 1110 GC: On the PTV page of the method editor, the Split Ratio parameter was
not checked to ensure a valid value was entered.
TRACE 1300 GC: It was not possible to use custom injection variables or custom
sequence variables as part of the instrument method script.
TRACE 1300 GC: On the Aux Columns ePanel, the Column Parameters for Aux
Columns was set incorrectly when more than 2 Inlets were configured.
TRACE 1300 GC: On the Inlet method page, the He Saver Delay Time was limited to a
maximum of 0.5 minutes, even though the hardware supported a time up to 2.0
minutes.
TRACE GC Ultra: If an instrument method with an isothermal oven segment at the
beginning was used for a sample type blank, the isothermal section was ignored.
CM7‐23306
CM7‐23749
CM7‐23592
CM7‐17326
CM7‐23911
CM7‐23072
CM7‐23913
CM7‐24141
CM7‐24140
CM7‐18753
CM7‐18754
CM7‐19607
CM6‐23654
CM7‐20118
CM7‐14454
CM7‐23317
CM6‐24124
CM6‐23871
CM6‐24109
CM6‐24169
TriPlus 300 HS: Although the hardware supports an optional bar code reader, there
was no way to report the bar code value that was read.
TriPlus RSH and TriPlus 100LS: After Editing Custom Cycle Parameters, it was not
possible to save the edited method until a change was made elsewhere in the
method.
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Chromeleon 7
ID
Description
CM7‐23177
TriPlus RSH and TriPlus 100LS: After opening and closing the Virtual Terminal, it was
not possible to restart the Chromeleon Console.
TriPlus RSH and TriPlus 100LS: If a sample fished acquiring before the sampler
finished its injection cycle (e.g. due to post‐injection washes), the sequence would
interrupt with following error in the audit trail: "Timeout while waiting for the
instrument to finish, the current injection will be aborted."
TriPlus RSH and TriPlus 100LS: When running sequences on an instrument using
version 2.4 of the firmware, occasionally the sequences would abort with an error
message stating "There is a problem with accessing the instrument."
TriPlus RSH: Although it was possible to condition the SPME fiber as part of an
instrument method, it was not possible to do so manually.
CM6‐24212
CM7‐23711
CM7‐21564
CM6‐23479
TriPlus RSH: When operating in SPME mode, the TriPlus RSH would schedule samples
so as to overlap oven programs, but did not optimize based on the various SPME
incubation steps.
CM7‐24009
TriPlus RSH: It was not possible to manually condition the SPME Arrow tool
CM6‐24161
TriPlus RSH: It was not possible to start a sequence if one of the agitator positions
was configured as a Reserved Position using a different vial type.
TriPlus RSH: With an instrument configuration that included both a TriPlus RSH and a
Manual Inject module, occasionally the state for an injection would never transition
to 'Finished', effectively hanging the sequence. The issue was only seen for injection
rows that used the Manual Inject option.
TSP UV 6000 PDA, Surveyor PDA, Surveyor Plus PDA and Accela PDA: Occasionally
during acquisition, an "Access Violation" error was generated, halting the sequence.
CM6‐24168
CM6‐24151
CM7‐19507
UltiMate AFC‐3000, WPS‐3000 (FC variants): When creating an instrument method
with fraction collection, the option for fraction pooling was always disabled.
CM7‐23624
URG‐9000: When installed on the French version of Windows 7, a format error would
be displayed instead of the floating point calibration values.
Vanquish Autosampler: When using a Waters48 Rack type, it was not possible to
address the last two columns of the rack (7/8).
Waters Acquity: If an Acquity instrument had previously been configured and then
deleted, it was not possible to see the modules when attempting to configure an
Acquity instrument at a later point. While the problem has been solved in
Chromeleon 7.2 SR5 MUa, users of versions older than this should contact Thermo
Fisher Scientific for further information.
CM6‐23927
CM7‐23178
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5 Limitations and Known Issues
The following sections list known issues and limitations. The numbers in the first column of the table
below refer to the Thermo Fisher Scientific tracking IDs.
5.1 Limitations with Thermo Scientific Instruments
ID
Description
CM7‐16851
UltiMate 3000 MWD‐3000 and DAD‐3000: In the Instrument Method Editor for these
devices, the script page offers one additional option for the data collection rate (20 Hz)
that is not present in the Instrument Method Wizard. This additional option is a valid
value for this parameter.
Although it is possible to manually type in a value for the data collection rate that is not
in the list, these values will be rejected by the Ready Check when a sequence is
submitted.
CM7‐17783
UltiMate 3000 WPS‐3000FC: When using the WPS‐FC, the needle will not automatically
be flushed prior to collecting the first fraction. To work around this limitation, add the
following lines to the instrument method command script:
Sampler.EndFraction
Sampler.Collect
Delay 10
Sampler.Drain
CM7‐21342
Vanquish Variable Wavelength Detector: For acquiring data on a single channel only
using the Vanquish VWD it is necessary to use channel UV_VIS_1.
CM6‐21321
Accela Open Autosampler: When using this autosampler, a dot (‘.’) must be used as
decimal separator.
CM7‐18098
Accela Open Autosampler: Sequences cannot be run when the sampler does not
include the DLW option. This configuration is not supported and requires a custom
script.
CM6‐22760
TRACE 1300 GC: The autozero function does not work correctly for the FID, NPD, ECD
and FPD detector types.
CM6‐23614
TriPlus RSH: When using the TriPlus RSH in constant double pro headspace mode,
starting a sequence that includes a constant double pro method will generate a
validation error.
CM7‐20295
TSQ 8000 and ISQ Series: When a GC‐MS instrument method includes a scan event
containing multiple SIM ions (e.g. “SIM 115, 152, 188”) then data from matching filters
collected at different time ranges will not be combined into a single filter in the data for
that injection.
CM7‐23669
TSQ8000 Series: If you attempt to abort an acquisition of multiple timed acquisitions
while the MS is acquiring data, the MS will not cycle back to a Ready state and the
sequence will not end. It is necessary to stop and restart the Instrument Controller to
regain access to the instrument.
CM7‐15632
TSQ Quantiva and Endura: When removing the source from a TSQ Quantiva or Endura
in mid‐acquisition, the sequence does not abort.
CM7‐16030
TSQ Quantiva and Endura: With these instruments the standby state reports that the
instrument is on, regardless of the real instrument state.
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ID
Description
CM7‐16154
TSQ Quantiva and Endura: When creating an Instrument Method for the TSQ Endura or
TSQ Quantiva, the MS run time is not the same as the Chromeleon run time. The user
should enter the correct run time on the MS page of the Wizard.
CM7‐17668
TSQ Quantiva and Endura: TSQ Endura and TSQ Quantiva instruments are usually
shipped with a PC (“Endura/Quantiva PC”) that includes all the necessary instrument
data files, such as calibration files, for operating the MS instrument. If you want to
control an instrument using a different PC, make sure that the specific instrument data
files residing on the Endura or Quantiva PC are backed up and transferred to the new
PC. For details on performing this process, please consult with your local MS field
service engineer.
CM7‐18129
TSQ Quantiva and Endura: After an upgrade of the TSQ Endura/Quantiva instrument
driver, an error may occur when opening the Chromeleon Instrument Configuration. To
resolve the error, remove the Chromeleon Mass Spectrometer driver from the
configuration and then add it again. This will update the configuration information in
Chromeleon to match the updated TSQ Endura/Quantiva instrument driver version.
CM7‐21967
TSQ Quantiva and Endura: The TSQ Endura and Quantiva mass spectrometer method
editor is supported on English operating systems with English/United States regional
settings only.
CM7‐17500
Exactive Series: Exactive Series instruments are usually shipped with a PC (“Exactive
PC”) that includes all the necessary instrument data files, such as calibration files, for
operating the instrument. If you want to control an Exactive instrument using a
different PC, make sure that the specific instrument data files residing on the Exactive
PC are backed up and transferred to the new PC. For details on performing the data
backup on the Exactive PC, refer to the Thermo Exactive Series 2.5 SP1 Release Notes,
section Backup provided on the Chromeleon installation disk in the Packages\Thermo
Exactive\Documentation folder.
CM7‐22490
Exactive Series: When setting the divert valve parameters for an Exactive Series MS
with a 2‐position valve, the valve positions are recorded in the MS raw data opposite of
how the divert valve parameters were configured.
CM7‐23295
Exactive Series: Due to differences in how the Exactive 2.8 SP1 driver writes the scan
header in MS data files during acquisition, non‐targeted peak detection will not work
correctly when data generated from both the Exactive 2.8 SP1 driver and older drivers
are present in the same sequence.
CM7‐16557
MSQ Plus and Tune Application: When using the MSQ Plus with Chromeleon the user
has to wait for the Chromeleon Instrument Controller to be in idle mode before
opening the Tune application. Without waiting, the MSQ Plus will not be able to change
the operating mode (On, Off, Standby), or it will not be possible to run injections. To
recover from this error both the PC and the MSQ Plus would have to be restarted.
CM7‐23138
MSQ Plus: It is recommended to use only the MS driver provided on the Chromeleon
installation medium. Other versions of the MSQ Plus driver may not be compatible with
Chromeleon. Please consult your local field service engineer for additional details.
5.2 Compatibility of Chromeleon 7.2.6 and SII for Xcalibur
At current time, SII for Xcalibur (SII) has not been validated for use with Chromeleon 7.2.6. As such
any installation combining SII with Chromeleon 7.2.6 is not supported. At a time when SII is
compatible with this release, documentation outlining support will be released which will supersede
this known limitation.
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5.3 Mass Spectrometers and Windows 10
Thermo Scientific Foundation 3.0 SP2 is required for mass spectrometer support under Chromeleon.
As Foundation 3.0 SP2 is not compatible with Windows 10, no mass spectrometers other than the
ISQ EC are supported under Windows 10 at this point in time.
5.4 Upgrading a Windows 10 PC From Chromeleon 7.2 SR5 to
Chromeleon 7.2.6
When Chromeleon 7.2 SR5 is installed on a Windows 10 PC, upgrading that PC to Chromeleon 7.2.6
will appear to complete successfully, with no IQ errors or warnings. However, attempting to export a
sequence to PDF will fail with an error stating “Printer not activated, error code – 30”.
To resolve this problem, rerun the Chromeleon 7.2.6 setup, selecting ‘Repair’ on the opening screen
of the setup program.
5.5 Compatibility with Foundation 3.1
Chromeleon is only compatible with Thermo Foundation 3.0 SP2. Users may encounter situations
where PCs provided with mass spectrometers come pre‐installed with Foundation 3.1 or newer. In
these instances, the factory procedure to uninstall any MS instrument control component software
must first be followed before reinstalling Foundation 3.0 SP2 and the mass spectrometer driver.
This procedure must only be carried out by individuals that have completed the necessary software
and hardware training.
5.6 Limitations with the Waters Driver Pack
ID
Description
CM6‐21040
Waters Acquity: Should a Waters instrument detect an IP address conflict during start
up, the Chromeleon CDS driver will log the error message in the Audit Trail. If this
message is ignored, it will be displayed again after 2 hours, which can result in a running
sample being aborted.
CM6‐21112
Waters 2998 PDA: Localization to a non‐English regional setting for the PC (e.g.,
German) does not function correctly for the timed events table, e.g., using a Waters
2998 PDA detector and setting a timed event in the program file (e.g., wavelength
change at 5 minutes). The event is recorded, but without the event time.
CM6‐24158
Waters 2489 PDA: After changing the Instrument Method from single to dual‐
wavelength mode (without changing Channel A wavelength), the data rate for Channel
B is set incorrectly and incomplete data collection occurs.
CM6‐23194
After removing the Sample Organizer from the Instrument Configuration, the plate
setup is not updated correctly. Manually updating the plate settings in the plate setup
configuration dialog avoids this issue. If the total length of the instrument name plus
detector name is more than 32 characters, the sequence will abort shortly after initial
injection. The affected detectors are: 2489, 2998, and Acquity FLR.
CM7‐19830
When using the Waters Acquity driver in a Citrix environment, the Acquity console does
not update correctly and therefore doesn't show current log file entries. This is due to a
problem in the Acquity console, and can be mitigated by using the instrument audit trail
on remote clients.
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ID
Description
CM6‐24164
When the Waters Driver Pack 4 is installed in a Citrix environment, the World WIde
Web Publishing Service is automatically disabled, so that after restarting the PC, the
Citrix web application is no longer reachable. The service should be reset to automatic
start, after which the application can be reached
CM7‐22872
When using the Waters Acquity driver, some Chromeleon screens may not appear
properly, such that text from the previous screen is still visible. This has been observed
with the Sequence Properties and the Chromeleon Log on screen.
CM7‐23504
In rare circumstances when the user configures and then deletes an Acquity PDA, the
module will still be shown in the Acquity Console. If a command is then executed (e.g.
lamp on), the module disappears from the console, after which the user then needs to
reconfigure the instrument in the Chromeleon Instrument Configuration Manager in
order e.g. to turn off the lamp.
CM6‐24191
In extremely rare cases the Acquity PDA server stops working, which then causes the
running sequence to be interrupted.
CM7‐23730
When using the Waters Acquity Driver Pack4 and trying either to create a new
instrument method, or to open the Acquity console from the ePanel a problem
sometimes occurs. A message appears informing the user that launching the application
had failed, and that the Acquity driver pack may not be installed. If this occurs, the user
should contact Thermo Fisher Scientific for further advice.
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5.7 Limitations with Agilent ICF
For a general overview regarding the Agilent Instrument Control Framework, please refer to the
document Chromeleon and Agilent ICF ‐ Quick Start Guide ‐ Chromeleon 7.2 .pdf, found in the
\Documents\ folder of the Chromeleon 7.2 CDS DVD.
ID
Description
CM7‐19347
Agilent G1312B DAD: When using a G1312B DAD in combination with an old JetDirect
card, the user may experience problems collecting data at 80Hz. If the user observes
this, they should get in touch with their local Thermo Fisher Scientific representative for
advice on possible solutions.
CM7‐20047
Agilent VWD G1314B: When using a G1314B VWD, occasionally the chromatogram is
half the expected length.
CM7‐20991
Agilent ICF: Occasionally when performing injections with ICF controlled instruments
the injection volume is incorrectly displayed, although the injection itself was
performed correctly.
CM7‐21172
Agilent ICF: If the user has the monitor DPI settings on their PC set at greater than
100%, then some parts of the Agilent LC system device ePanel are not visible.
CM7‐23096
Agilent ICF: If a Fraction Collector with Thermostat is installed, the channel mapping is
not correct. This can be resolved by removing the
node from DefaultConfiguration.xml before adding the driver. After this, the user can
configure the mapping for the two channels manually on the Signals (2D) tab of the
configuration dialog.
CM7‐19540
Agilent ICF: The Agilent GC System Configuration dialog includes entries to configure
the 7697A Headspace, G1888A Headspace, 7890 GC, 6890 GC, 68550 GC, and 7820 GC.
Currently, it is only possible to configure the 7697A Headspace sampler. Attempting to
configure any of the other modules will result in a message indicating that the modules
are not supported.
CM7‐19863
Agilent ICF: The Agilent LC System Configuration dialog includes entries to configure the
following devices, which are not supported by the release:
All ELS Detectors (Drivers are not included, so they cannot be configured)
Multi‐sampler and DAD HDR (Although configurable, they have several known issues
and are therefore not supported)
CM7‐21427,
CM7‐18984
Agilent ICF with 1100 or 1200 LC DAD: When acquiring data from an Agilent 1100 or
1200 LC DAD, the signal trace may be shifted to the start of the run, and the end time is
inconsistent. No data points are lost with a data rate of
10 Hz and slower (>= 0.025 min 0.5 sec)
20 Hz and a low number of spectra (all other than ALL Spectra)
20 Hz and spectrum range 190‐ 400 step 2
CM6‐23980
Agilent 7697A: When starting a sequence while the 7697A Headspace Sampler is in an
‘Error’, ‘Running’, or ‘Not Connected’ state, the ready check does not give an error
message. After the sequence starts, the following happens:
If the sampler is in error state, the sequence starts without getting interrupted
If the sampler is running, the sequence stops with audit trail message “Sequence
stopped by user”
If the sampler is not connected, the sequence interrupts with audit trail messages “Lost
connection to Agilent 7697A Headspace Sampler", and "The instrument is offline. Check
power to all modules, cabling between modules and whether the configuration
matches the list of modules."
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Chromeleon 7
ID
Description
CM6‐23992
Agilent 7697A: The 7697 Headspace Sampler has two versions; 111‐ and 12‐vial
capacity configurations. The Chromeleon driver is written and tested with the 111 vial
capacity version. Though not tested, the driver is expected to work with the 12‐vial
capacity module. The user should not use vial positions greater than 12 in this case. The
rack view always shows 111 vial positions.
CM6‐24004
Agilent 7697A: Using the instrument front panel, the allowed range for Transfer Line
Diameter is 200‐600 microns. However, when setting this value in the Chromeleon
instrument configuration the limit is 250‐530 microns.
CM6‐24005
Agilent 7697A: When 7697A headspace instrument method parameters are included in
a report, the “fill pressure” parameter is rounded to the nearest integer.
CM6‐24007
Agilent 7697A: Some parameters logged to the instrument audit trail are rounded to
nearest integer. However, all values are downloaded to the instrument with the proper
precision.
CM6‐24008
Agilent 7697A: When editing an existing 7697A Headspace instrument method, if the
values for Purge Flow, Purge Time or Leak Flow are changed, the Save button is not
enabled until the user changes tabs.
CM6‐24009
Agilent 7697A: When configuring an Agilent 7697A, there is an option in the user
interface to “Upload Config from Instrument”. This option does not work. Instead, you
will need to manually configure the instrument settings.
CM6‐23996,
CM7‐19940,
Agilent 7697A: The 7697 Headspace Autosampler has two options for handling missing
vials: Pause and Abort. An issue has been observed when the Abort option has been
selected. In either mode, the autosampler overlaps sample preparation, i.e.: sample 2
is prepared while sample 1 is acquiring. If the autosampler finds that the sample 1 vial
is missing, it will Abort or Pause the sequence at the point it discovers the vial is
missing. However, if the autosampler finds that the sample 2 vial is missing, while
sample 1 is already acquiring, and the Abort option has been selected, the entire
sequence will be aborted, including the acquiring sample 1.
CM7‐21324
CM7‐19975,
CM7‐20451
Agilent 7697A: The Soft Config option, available via the ICF for Agilent LCs, is not
supported for the Agilent 7697 HS. It should not be added to any custom ePanel as its
use can cause issues by allowing configuration changes to be applied to the sampler
during acquisition.
CM7‐19993
Agilent 7697A: If the 7697A loses its connection to the network, an audit trail message
is added indicating this fact. However, the ePanel will still show the unit as ‘Ready’.
CM7‐20259
Agilent 7697A: Although the vial position may be assigned in the instrument method
script, unless this is done in the Instrument Setup Stage, the sequence table will not be
updated. This can result in misleading information in reports and should be avoided.
CM7‐23242
Agilent 7697A: Running multiple 7697A Headspace autosamplers on a single 247
Instrument Controller can cause Windows "Out Of Memory" errors, requiring a reboot
of the 247 to resolve. Thermo Fisher therefore recommends that only one 7697A is
connected to any 247 Instrument Controller.
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5.8 Limitations with Other Third Party Instruments
ID
Description
CM7‐17948
Shimadzu LC: Unlike most drivers, some Shimadzu UV detectors require that you select
the Advanced filter in the Command (F8) window in order to access the Lamp On/Off
command.
CM7‐24042
Instrument Configuration Manager: The .NET 4.7 framework is installed by Windows
Update. For Windows 7 it is a recommended update, but for Windows 10 it is a
mandatory update. This release of Chromeleon has been validated against .NET 4.7.
However, under rare circumstances, the installation of .NET 4.7 could lead to
malfunctioning or crashes of the instrument configuration manager or configuration
plug‐ins. If this occurs, please contact your Chromeleon support desk for assistance in
correcting the problem.
CM6‐23947
Shimadzu LC‐10A, LC‐2010: If the user cancels the keylock state of the front panel of the
instrument and then, for example, stops a manual acquisition, this is likely to lead to
unexpected effects during the next operation such as sudden abort of the sample run.
CM7‐15400,
CM7‐15556,
CM7‐15734,
CM7‐15736
Perkin Elmer LC200 Autosampler: When upgrading from earlier versions of Chromeleon
7 CDS to Chromeleon 7.2 CDS SR3, it is necessary to reload the Perkin Elmer LC200
Autosampler driver and configure the loop size within the configuration. The user
should then check all instrument methods using this autosampler to ensure that they
continue to function correctly.
CM7‐15716
PerkinElmer Clarus 400 GC: Some users must select Autosystem XL in configuration in
order to communicate with the PerkinElmer Clarus™ 400.
CM7‐20464
Varian 3800 GC: It is not possible to start a manual data acquisition if the GC is not
ready (i.e. all temperatures, pressures and so on are at their set points). Trying to do so
will generate a Ready Check message detailing what is not ready.
CM7‐12366
Agilent 5890 DICE Card: Please note the following when using the19257 DICE card with
the Agilent 5890 GC:
Control and acquisition using the DICE card is only supported via the serial interface.
The GPIB interface is not supported.
Digital data acquisition via the serial interface of the DICE card is only supported for a
single channel; dual channel digital acquisition is not supported.
Currently, it is possible to select certain illegal combinations in the Configuration Dialog
such as:
Digital acquisition with the 19254 card. This is not supported.
Digital acquisition on one detector and analog acquisition on the other. Acquisition
needs to be exclusively digital or exclusively analog.
When using the DICE card to acquire data digitally, the 5890 INET mode must be set to
“GLOBAL” not “LOCAL”. Failure to do so will result in a “No response from GC” message
following the AcqOn command in the audit trail.
Note that when performing analog acquisition, the 5890 INET mode should still be set
to “LOCAL” (as described in the online help).
CM7‐9675
Agilent 7890 GC: There is a backward compatibility issue that affects the Agilent 7890
GC Sampler Positions. When using a 7890 GC in combination with a 7693 sampler,
certain positions in the sampler could give a misspelled value to a move command. This
has now been corrected and could in rare cases lead to Instrument Method files
needing to be updated to avoid errors.
CM7‐15293,
CM7‐18463
Agilent 1100 Obsolete Driver: Occasionally, when using a combination of older and
newer modules, the raw data was not correctly acquired.
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5.9 Other Limitations
ID
Description
SWFR‐2543
Sampling Devices That Do Not Use uL As Units for Volume: Although most liquid
injection devices expect volumes to be entered in uL, there are a few devices (e.g.
Thermo AS‐HV and Perkin‐Elmer GC Autosampler) which do not use µL as their default
volume unit. If one of these devices is configured in the same instrument that also
includes an injection device that uses µL, problems may be observed with volume
validation in the sequence table as well as units associated with volumes in reports.
CM7‐21780
NIST MS Search and Demo Library No Longer Automatically Installed: Incompatibilities
of the NIST 2008 MS Demo Library installer with Window 7 and 10 could cause the main
Chromeleon installer to hang or crash. To address this, the NIST Demo library, and the
associated AMDIS and MS Search software are no longer automatically installed when
you install Chromeleon. If desired, this package may be installed manually using the
setup program found in the /Tools/ folder of the Chromeleon DVD. Alternatively, one
may install AMDIS and MS Search using the full (licensed) NIST library installer.
Note that MS library searching within the Chromatography Studio is not affected by this
issue.
CM7‐21783
Performance When Importing Fixed Calibration Standards for MS Sequences: When
working with sequences of MS data, importing injections for use in a fixed calibration
can take 1‐2 minutes to complete, depending on the data.
CM7‐18252
Export MS Raw Data: When acquiring MS data, Chromeleon acquires MS data and all
other signal data, such as UV, FLD, and pump pressure signals, in separate formats. As a
result, when MS data is exported, non‐MS data is not exported with the MS raw data
file.
CM7‐20335
Comparison of Old Report Versions Shows Change in CmbxExportParameters: If a
report which was created in Chromeleon 7.2 SR2 or earlier, and modified in SR3, has its
history compared in SR4, the history will appear to show that the "Cmbx Export
Parameters" value has changed from True to False. This is due to a change in the
default value of this field, and does not represent any user‐modification of the report.
CM7‐17203
Report Designer: With some date/time formatting settings in the report, the order of
month and day changes for some formats automatically. The settings in the Report
Template can change based on the windows regional settings. For example it is not
possible to set m.d.yy as format with German regional settings. The Report Template
replaces this with d.m.yyyy. The substitution occurs for report variables and non‐report
variable entries.
CM7‐17841
Report Designer: If using a non‐Chinese format as the regional setting in Windows, and
Chinese as the setting for Non‐Unicode programs, then the header on a Chromeleon
report is not correctly displayed for variables. If the format is changed to Chinese, then
everything is correctly displayed.
CM7‐21331
Report Variable chm.massSpectrum("...").resolution always shows "0,5000": The mass
spectrum resolution report variable returns an internally used processing value instead
of the resolution setting defined in the MS instrument method. It is recommended to
discontinue use of this report variable until further notice.
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ID
Description
CM7‐20449
User Management: Login "Role" dropdown box becomes empty after upgrading to
Chromeleon 7.2 SR4. This is due to the fix for CM7‐18178 "Roles were offered in the
Logon dialogue, even if they were not specified as Logon roles". To work around this
issue, enable the "Logon Role" property in the user database for all logon roles that
users need to be able to select.
CM6‐23886
Exception Error When Removing USB‐>COM Port Adapter: If a USB‐to‐RS232 adapter is
used to provide COM communication between an Instrument PC or 247 Instrument
Controller and an instrument, and the USB connection is unplugged, Chromeleon
reports a Fatal Error in the Instrument Audit trail. The USB‐to‐RS232 adapter should not
be disconnected from the Instrument PC or 247 Instrument Controller while it is
powered‐on.
CM7‐19336
Chromeleon 6 Import: Due to changes in Auditing between Chromeleon 6 and
Chromeleon 7, when a Chromeleon 6 Sequence is imported into Chromeleon 7, some of
the text displayed in the Instrument Audit trail will not appear exactly as it did in
Chromeleon 6. Refer to the topic "Viewing Chromeleon 6 Data" in the online help for
further information.
CM7‐21399
Injection Variables 'Auto Dilution Ratio' and 'Retention Time Standard': Auto Dilution
Ratio and Retention Time Standard columns are not available in the custom filter
conditions for injection records (e.g., in the IRC editor or summary report).
CM7‐22111
Mixed Installations with Chromeleon 7.2 SR5 Domain Controller: If you have an existing
installation of Chromeleon < 7.2 SR1, the following limitations apply during an upgrade:
Stations that have Chromeleon 7.2 or below installed will not see any data vaults or
instruments that have been created with Chromeleon 7.2 SR5, until after those stations
are upgraded to 7.2 SR5.
It is not possible for a Chromeleon 7.2 (and below) station to join a Chromeleon 7.2 SR5
domain.
Stations that have Chromeleon 7.2 or below will not receive any updates from the
Discovery Service after the Chromeleon domain controller has been upgraded to 7.2
SR5, and will only see resources that were already in existence and cached.
Please refer to the Enterprise Documentation for guidance on upgrading an older
installation of Chromeleon 7 to Chromeleon 7.2 SR5.
CM7‐22145
Discrepancy in “Last Modified” Time: Owing to differing rounding methods used, it is
possible that the value of the "last modified" time for an object in a sequence has a
difference of 1 second between the client display and the value shown in a report. For
more details, please see the on‐line help.
CM7‐24058
Console: The new eWorkflow option "Preserve Layout", introduced in Chromeleon 7.2.6
is not backwards compatible with older versions of Chromeleon. If a client with an
earlier version attempts to open an eWorkflow for which this option is enabled, the
error message "Cannot load, as the data was created with a newer Chromeleon
version.” Is displayed.
CM7‐20637
Logon with Current Windows Account after Disconnecting Network Fails with
Misleading Error Message: In the event of a loss of network connection on a system
using LDAP logon, attempting to logon to Chromeleon again with the same account
details results in a misleading error message "The user name or password are
incorrect."
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Chromeleon 7
ID
Description
CM7‐23033
Legacy Upload: With replication framework disabled, when trying to modify a sequence
while the automatic upload is already in progress the upload may fail in very rare cases
and it is not possible to remove the sequence from the instrument queue by retry of
the upload. To recover the sequence a copy of the sequence has to be stored manually.
Chromeleon 7.2 SR5 adds an audit trail entry to the manually uploaded sequence that
refers to the original sequence so that traceability is ensured.
Thermo Fisher Scientific recommends to enable the replication framework with
Chromeleon 7.2 SR5 to avoid the problem.
CM7‐23481
Fatal Error in Chromeleon 7 Real Time Kernel Service: When leaving the Instrument
Configuration Manager open over extended periods of time the Chromeleon Real Time
Kernel Service might stop unexpectedly with a fatal error in the Windows Event Log.
5.10 Obsolete Drivers
Chromeleon includes a number of obsolete drivers in order to provide backward compatibility of
existing installations:
Agilent/HP 1200 HPLC System
AI 1310/3000 GC Sampler ‐ 10ul
AI 1310/3000 GC Sampler ‐ 5ul
AI 1310/3000 GC Sampler ‐ 5ul ‐ 155 Vials
AI 1310/3000 GC Sampler ‐ 5ul ‐ 105 Vials
AI 1310/3000 GC Sampler ‐ 10ul ‐ 155 Vials
AI 1310/3000 GC Sampler ‐ 10ul ‐ 105 Vials
PAL Sampler for GC
PAL Sampler for LC
TRACE 1300 Series GC (First generation driver that has been superseded by TRACE 1300 Series GC
II driver)
Please note that issues reported for any of these drivers will no longer be addressed. If you are using
one of these drivers Thermo Fisher Scientific recommends migrating to a supported driver as soon as
possible.
5.11 Defects Under Investigation
The following defects have only occurred very rarely, and data necessary for investigation, such as
log files and backups, are insufficient to reproduce the problem. Despite significant testing efforts in
various configurations we could not reproduce this behavior in systems that are set up and
configured as recommended by Thermo Fisher. Thermo Fisher is therefore unable to identify the root
cause of the problem and provide technical modifications of the software that would allow us to
confidently state that we prevent future incidents of such behavior. We are continuing investigation
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of these issues but would like to share symptoms of this behavior with our customer base and give
recommendations to remediate from the behavior if it occurs.
Note: If you are affected by any of these defects, please collect a System Status Report
immediately and contact your local Thermo Fisher representative for further assistance.
5.11.1 Empty Inject Time and GUID Fields in the Injection Record [CM7‐22738]
Empty Inject Time and GUID fields have been seen in a few single injections. Raw data have been
successfully acquired and stored on the local Instrument PC. The Injection Audit Trail on the
Instrument PC contains complete information, including the missing details. Too few instances have
been reported to identify the root cause of this problem.
Note: If you are affected by this problem, please contact your local Thermo Fisher representative
for assistance with recovery of the missing injection details.
5.11.2 Instrument Audit Trails Are not Properly Saved/Written on the local Data
Vault [CM7‐23051]
In one installation, a few Sequences aborted with the following error messages in the audit trail:
“The audit trail was unavailable for some time. Several audit trail messages are lost. They have been
logged to the file "Dionex\Chromeleon\Log\AuditTrailMessages.log" in the (common) application
data folder.”
During investigation of the log files of affected Instrument Controller PCs errors of slow file
operations on the local hard drive have been found:
“SQL Server has encountered 1 occurrence(s) of I/O requests taking longer than 15 seconds to
complete on file [C:\ProgramData\Dionex\Chromeleon\DataVaults\XVault\XVault_log.LDF] in
database [XVault] (6)“
It has been confirmed that the failure was caused by poor disk drive performance and only occurred
over a limited period of time. Chromeleon 7.2 SR5 introduces additional error handling and reporting
so that similar errors can be identified more easily.
5.12 Functional Differences between Chromeleon 7.2 and Chromeleon
6.8
Chromeleon 7.2 SR5 MUa implements the vast majority of Chromeleon 6.8 features, and in general,
has a richer feature set than Chromeleon 6.8. However, a few Chromeleon 6.8 features remain to be
implemented on the Chromeleon 7 platform and a few will never be implemented, since they are
now obsolete or no longer relevant. If a particular missing feature is important to you, please
contact your local Thermo Fisher Scientific representative to find out if that feature is in the product
development plans.
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6 Backward/Forward Compatibility Issues
6.1 Thermo Scientific Vanquish Charged Aerosol Detector [CM6‐23499]
Any Instrument Methods created for the Vanquish Charged Aerosol detector with Chromeleon 7.2
SR2 MUa and earlier may need to be updated due to changes in the driver introduced in Chromeleon
7.2 SR2 MUb.
6.2 Thermo Scientific Vanquish Autosampler [CM6‐23405]
Any Instrument Methods created for the Vanquish Autosampler containing the WashSpeed property
will need to be updated. The WashSpeed value needs to be divided by 0.06 in order for the
Instrument Method to work correctly.
6.3 Thermo Scientific TriPlus RSH
The current driver for this instrument is incompatible with firmware older than version 2.4.
6.4 Thermo Scientific TriPlus 300 HS
The current driver for this instrument is incompatible with firmware older than 2001.9.0.
6.5 Thermo Scientific TriPlus LS‐100
The current driver for this instrument is incompatible with firmware older than version 2.4.
6.6 Thermo Scientific TSQ Quantiva
The driver version 1.1 QF1 for this instrument, included in this Service Release, may not be
compatible with existing TSQ Quantiva mass spectrometers running driver version 1.0 without a
hardware update. Please contact your local MS service engineer before attempting to upgrade the
unit.
Note: New TSQ Quantiva modules from the factory are not affected by this issue.
6.7 Thermo Scientific TSQ Quantiva and Endura
The driver version 1.1 SP1 for these instruments may not be compatible with existing TSQ Quantiva
and Endura mass spectrometers running driver version 1.0 without a hardware update. Please
contact your local MS field service engineer before attempting to upgrade the unit.
Note: New TSQ Quantiva and Endura modules from the factory are not affected by this issue.
6.8 TSQ Quantiva and Endura Instrument Method [CM7‐18759]
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Instrument methods created with older versions of the TSQ Quantiva and Endura instrument method
editor cannot be opened with newer versions of the method editor. If a large number of instrument
methods have already been created for regular use, upgrade of the TSQ Quantiva and Endura driver
is not recommended. Contact your local Thermo Fisher Scientific representative for additional
details.
6.9 Signed Sequences [CM7‐16374]
Sequences that have been signed within Chromeleon 7.2 SR1 will fail verification after copying within
later versions of Chromeleon 7.2 CDS.
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7 Appendix
This chapter contains general Information about Service Releases, Release Notes, Online Help, and
Contributed Content.
7.1 Release Notes
The Release Notes list the new features and improvements of the current release. Included in these
Release Notes are all of the functionality and bug fixes from Chromeleon 7.2 SR5 MUa and
Chromeleon 7.2 SR5 MUb. For details about Chromeleon 7.2 SR5 and other previous releases, refer
to the relevant release notes which can be found on the Chromeleon 7.2.6 DVD.
7.2 Online Help
In general, new features, updates and drivers that are introduced with this release are described in
an updated Online Help that is distributed with the release.
7.3 Contributed Content
The Chromeleon 7 disk contains a folder titled Contributed Content. This folder contains:
Demonstration Material
Localized Documents
Localized ePanels
Localized Report Templates
eWorkflow Templates
User Management Example
Charlie Mouse Pointer
Note: The files in the Contributed Content folder have not been tested and validated according to
Thermo Fisher Scientific Software Development Cycle guidelines modeled after ISO 9001:2008
standards. Thermo Fisher Scientific assumes no responsibility for any errors that may appear in
the content provided in the Contributed Content folder.
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